-- dump date 20120504_145720 -- class Genbank::misc_feature -- table misc_feature_note -- id note 502025000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 502025000002 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 502025000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000004 Walker A motif; other site 502025000005 ATP binding site [chemical binding]; other site 502025000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000007 Walker B motif; other site 502025000008 arginine finger; other site 502025000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 502025000010 DnaA box-binding interface [nucleotide binding]; other site 502025000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 502025000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 502025000013 putative DNA binding surface [nucleotide binding]; other site 502025000014 dimer interface [polypeptide binding]; other site 502025000015 beta-clamp/clamp loader binding surface; other site 502025000016 beta-clamp/translesion DNA polymerase binding surface; other site 502025000017 recombination protein F; Reviewed; Region: recF; PRK00064 502025000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000019 Walker A/P-loop; other site 502025000020 ATP binding site [chemical binding]; other site 502025000021 Q-loop/lid; other site 502025000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000023 ABC transporter signature motif; other site 502025000024 Walker B; other site 502025000025 D-loop; other site 502025000026 H-loop/switch region; other site 502025000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 502025000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000029 Mg2+ binding site [ion binding]; other site 502025000030 G-X-G motif; other site 502025000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 502025000032 anchoring element; other site 502025000033 dimer interface [polypeptide binding]; other site 502025000034 ATP binding site [chemical binding]; other site 502025000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 502025000036 active site 502025000037 putative metal-binding site [ion binding]; other site 502025000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 502025000039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 502025000040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000041 dimer interface [polypeptide binding]; other site 502025000042 active site 502025000043 CoA binding pocket [chemical binding]; other site 502025000044 multifunctional aminopeptidase A; Provisional; Region: PRK00913 502025000045 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025000046 interface (dimer of trimers) [polypeptide binding]; other site 502025000047 Substrate-binding/catalytic site; other site 502025000048 Zn-binding sites [ion binding]; other site 502025000049 Protein of unknown function DUF72; Region: DUF72; cl00777 502025000050 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 502025000051 active site 502025000052 intersubunit interactions; other site 502025000053 catalytic residue [active] 502025000054 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025000055 nudix motif; other site 502025000056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025000057 S-adenosylmethionine binding site [chemical binding]; other site 502025000058 excinuclease ABC subunit B; Provisional; Region: PRK05298 502025000059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025000060 ATP binding site [chemical binding]; other site 502025000061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025000062 nucleotide binding region [chemical binding]; other site 502025000063 ATP-binding site [chemical binding]; other site 502025000064 Ultra-violet resistance protein B; Region: UvrB; pfam12344 502025000065 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 502025000066 active site 502025000067 thiamine phosphate binding site [chemical binding]; other site 502025000068 pyrophosphate binding site [ion binding]; other site 502025000069 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025000070 Tetratricopeptide repeat; Region: TPR_6; pfam13174 502025000071 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025000072 ligand binding site [chemical binding]; other site 502025000073 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000075 active site 502025000076 phosphorylation site [posttranslational modification] 502025000077 intermolecular recognition site; other site 502025000078 dimerization interface [polypeptide binding]; other site 502025000079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000080 Walker A motif; other site 502025000081 ATP binding site [chemical binding]; other site 502025000082 Walker B motif; other site 502025000083 arginine finger; other site 502025000084 Helix-turn-helix domains; Region: HTH; cl00088 502025000085 Uncharacterized conserved protein [Function unknown]; Region: COG3268 502025000086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000087 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 502025000088 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 502025000089 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000090 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 502025000091 cell surface protein SprA; Region: surface_SprA; TIGR04189 502025000092 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 502025000093 O-Antigen ligase; Region: Wzy_C; cl04850 502025000094 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 502025000095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000096 Family description; Region: UvrD_C_2; cl15862 502025000097 arginine decarboxylase; Provisional; Region: PRK05354 502025000098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 502025000099 dimer interface [polypeptide binding]; other site 502025000100 active site 502025000101 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025000102 catalytic residues [active] 502025000103 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025000104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000105 phosphopeptide binding site; other site 502025000106 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025000107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000108 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 502025000109 Cytochrome c; Region: Cytochrom_C; cl11414 502025000110 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025000111 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025000112 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025000113 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025000114 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 502025000115 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025000116 CotH protein; Region: CotH; pfam08757 502025000117 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 502025000118 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 502025000119 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 502025000120 CHASE2 domain; Region: CHASE2; cl01732 502025000121 GAF domain; Region: GAF; cl15785 502025000122 Helix-turn-helix domains; Region: HTH; cl00088 502025000123 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025000124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025000126 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 502025000127 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 502025000128 active site 502025000129 purine riboside binding site [chemical binding]; other site 502025000130 glutathione synthetase; Provisional; Region: PRK05246 502025000131 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 502025000132 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025000133 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000135 active site 502025000136 phosphorylation site [posttranslational modification] 502025000137 intermolecular recognition site; other site 502025000138 dimerization interface [polypeptide binding]; other site 502025000139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000140 Walker A motif; other site 502025000141 ATP binding site [chemical binding]; other site 502025000142 Walker B motif; other site 502025000143 arginine finger; other site 502025000144 Helix-turn-helix domains; Region: HTH; cl00088 502025000145 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 502025000146 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025000147 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025000148 DNA binding residues [nucleotide binding] 502025000149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000150 binding surface 502025000151 TPR motif; other site 502025000152 TPR repeat; Region: TPR_11; pfam13414 502025000153 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025000154 active site 502025000155 substrate binding sites [chemical binding]; other site 502025000156 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 502025000157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000158 FeS/SAM binding site; other site 502025000159 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 502025000160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000161 FeS/SAM binding site; other site 502025000162 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 502025000163 phosphate binding site [ion binding]; other site 502025000164 dimer interface [polypeptide binding]; other site 502025000165 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 502025000166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025000168 non-specific DNA binding site [nucleotide binding]; other site 502025000169 salt bridge; other site 502025000170 sequence-specific DNA binding site [nucleotide binding]; other site 502025000171 Helix-turn-helix domains; Region: HTH; cl00088 502025000172 Protein of unknown function (DUF615); Region: DUF615; cl01147 502025000173 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 502025000174 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 502025000175 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025000176 SpaB C-terminal domain; Region: SpaB_C; cl14828 502025000177 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025000178 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025000179 Zn binding site [ion binding]; other site 502025000180 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025000181 tellurium resistance terB-like protein; Region: terB_like; cl11965 502025000182 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025000183 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 502025000184 active site 502025000185 metal binding site [ion binding]; metal-binding site 502025000186 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025000187 ligand binding site [chemical binding]; other site 502025000188 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 502025000189 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 502025000190 TPP-binding site [chemical binding]; other site 502025000191 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 502025000192 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 502025000193 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 502025000194 dimer interface [polypeptide binding]; other site 502025000195 PYR/PP interface [polypeptide binding]; other site 502025000196 TPP binding site [chemical binding]; other site 502025000197 substrate binding site [chemical binding]; other site 502025000198 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000199 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025000200 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000201 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000202 active site 502025000203 ATP binding site [chemical binding]; other site 502025000204 substrate binding site [chemical binding]; other site 502025000205 activation loop (A-loop); other site 502025000206 TPR repeat; Region: TPR_11; pfam13414 502025000207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000208 binding surface 502025000209 TPR motif; other site 502025000210 TPR repeat; Region: TPR_11; pfam13414 502025000211 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 502025000212 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 502025000213 VanZ like family; Region: VanZ; cl01971 502025000214 VanZ like family; Region: VanZ; cl01971 502025000215 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025000216 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025000217 acyl-CoA synthetase; Validated; Region: PRK07787 502025000218 AMP-binding enzyme; Region: AMP-binding; cl15778 502025000219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000220 active site 502025000221 ATP binding site [chemical binding]; other site 502025000222 substrate binding site [chemical binding]; other site 502025000223 activation loop (A-loop); other site 502025000224 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000226 Cache domain; Region: Cache_1; pfam02743 502025000227 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 502025000228 Chain length determinant protein; Region: Wzz; cl15801 502025000229 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 502025000230 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 502025000231 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025000232 Nucleotide binding site [chemical binding]; other site 502025000233 P loop; other site 502025000234 DTAP/Switch II; other site 502025000235 Switch I; other site 502025000236 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 502025000237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000238 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 502025000239 NAD(P) binding site [chemical binding]; other site 502025000240 NAD(P) binding pocket [chemical binding]; other site 502025000241 homodimer interface [polypeptide binding]; other site 502025000242 substrate binding site [chemical binding]; other site 502025000243 active site 502025000244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025000245 putative acyl-acceptor binding pocket; other site 502025000246 Ferredoxin [Energy production and conversion]; Region: COG1146 502025000247 4Fe-4S binding domain; Region: Fer4; cl02805 502025000248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000249 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 502025000250 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000251 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000252 active site 502025000253 ATP binding site [chemical binding]; other site 502025000254 substrate binding site [chemical binding]; other site 502025000255 activation loop (A-loop); other site 502025000256 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000257 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 502025000258 Amidase; Region: Amidase; cl11426 502025000259 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 502025000260 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 502025000261 active site 502025000262 substrate binding site [chemical binding]; other site 502025000263 FMN binding site [chemical binding]; other site 502025000264 putative catalytic residues [active] 502025000265 YceI-like domain; Region: YceI; cl01001 502025000266 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000267 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000268 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000269 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000270 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000271 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000272 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 502025000273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025000274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025000275 P-loop; other site 502025000276 Magnesium ion binding site [ion binding]; other site 502025000277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025000278 P-loop; other site 502025000279 Magnesium ion binding site [ion binding]; other site 502025000280 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 502025000281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025000282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 502025000283 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 502025000284 RDD family; Region: RDD; cl00746 502025000285 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000286 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025000287 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 502025000288 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 502025000289 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025000290 active site 502025000291 catalytic site [active] 502025000292 Protein kinase domain; Region: Pkinase; pfam00069 502025000293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000294 active site 502025000295 ATP binding site [chemical binding]; other site 502025000296 substrate binding site [chemical binding]; other site 502025000297 activation loop (A-loop); other site 502025000298 Predicted ATPase [General function prediction only]; Region: COG3899 502025000299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000301 binding surface 502025000302 TPR motif; other site 502025000303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025000304 binding surface 502025000305 TPR motif; other site 502025000306 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000307 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 502025000308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000310 homodimer interface [polypeptide binding]; other site 502025000311 catalytic residue [active] 502025000312 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025000313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025000314 RNA binding surface [nucleotide binding]; other site 502025000315 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025000316 active site 502025000317 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 502025000318 dimer interface [polypeptide binding]; other site 502025000319 substrate binding site [chemical binding]; other site 502025000320 metal binding sites [ion binding]; metal-binding site 502025000321 glutamate dehydrogenase; Provisional; Region: PRK09414 502025000322 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025000323 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 502025000324 NAD(P) binding site [chemical binding]; other site 502025000325 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 502025000326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000327 NAD(P) binding site [chemical binding]; other site 502025000328 active site 502025000329 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 502025000330 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 502025000331 active site 502025000332 HIGH motif; other site 502025000333 dimer interface [polypeptide binding]; other site 502025000334 KMSKS motif; other site 502025000335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025000336 RNA binding surface [nucleotide binding]; other site 502025000337 phosphodiesterase; Provisional; Region: PRK12704 502025000338 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 502025000339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025000340 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 502025000341 Cell division protein ZapA; Region: ZapA; cl01146 502025000342 Stage II sporulation protein; Region: SpoIID; pfam08486 502025000343 stage II sporulation protein D; Region: spore_II_D; TIGR02870 502025000344 Family description; Region: VCBS; pfam13517 502025000345 Family description; Region: VCBS; pfam13517 502025000346 Family description; Region: VCBS; pfam13517 502025000347 Family description; Region: VCBS; pfam13517 502025000348 Family description; Region: VCBS; pfam13517 502025000349 Family description; Region: VCBS; pfam13517 502025000350 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025000351 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 502025000352 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 502025000353 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000354 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000355 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000356 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025000357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025000358 catalytic residue [active] 502025000359 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 502025000360 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 502025000361 active site 502025000362 catalytic residues [active] 502025000363 metal binding site [ion binding]; metal-binding site 502025000364 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000366 active site 502025000367 phosphorylation site [posttranslational modification] 502025000368 intermolecular recognition site; other site 502025000369 dimerization interface [polypeptide binding]; other site 502025000370 chaperone protein DnaJ; Provisional; Region: PRK14282 502025000371 TPR repeat; Region: TPR_11; pfam13414 502025000372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000373 binding surface 502025000374 TPR motif; other site 502025000375 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 502025000376 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 502025000377 Walker A/P-loop; other site 502025000378 ATP binding site [chemical binding]; other site 502025000379 Q-loop/lid; other site 502025000380 ABC transporter signature motif; other site 502025000381 Walker B; other site 502025000382 D-loop; other site 502025000383 H-loop/switch region; other site 502025000384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025000385 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025000386 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 502025000387 Walker A/P-loop; other site 502025000388 ATP binding site [chemical binding]; other site 502025000389 Q-loop/lid; other site 502025000390 ABC transporter signature motif; other site 502025000391 Walker B; other site 502025000392 D-loop; other site 502025000393 H-loop/switch region; other site 502025000394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025000395 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 502025000396 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025000397 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 502025000398 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000399 dimer interface [polypeptide binding]; other site 502025000400 active site 502025000401 CoA binding pocket [chemical binding]; other site 502025000402 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 502025000403 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025000404 TolB amino-terminal domain; Region: TolB_N; cl00639 502025000405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000406 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000407 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000408 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000409 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000410 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025000411 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025000412 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025000413 Rhomboid family; Region: Rhomboid; cl11446 502025000414 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000415 phosphopeptide binding site; other site 502025000416 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000418 Walker A motif; other site 502025000419 ATP binding site [chemical binding]; other site 502025000420 Walker B motif; other site 502025000421 arginine finger; other site 502025000422 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 502025000423 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 502025000424 active site 502025000425 HIGH motif; other site 502025000426 dimer interface [polypeptide binding]; other site 502025000427 KMSKS motif; other site 502025000428 Putative zinc-finger; Region: zf-HC2; cl15806 502025000429 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 502025000430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000432 DNA binding residues [nucleotide binding] 502025000433 hypothetical protein; Reviewed; Region: PRK00024 502025000434 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 502025000435 MPN+ (JAMM) motif; other site 502025000436 Zinc-binding site [ion binding]; other site 502025000437 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025000438 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 502025000439 interface (dimer of trimers) [polypeptide binding]; other site 502025000440 Substrate-binding/catalytic site; other site 502025000441 Zn-binding sites [ion binding]; other site 502025000442 RF-1 domain; Region: RF-1; cl02875 502025000443 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 502025000444 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 502025000445 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 502025000446 DNA-K related protein; Region: DUF3731; pfam12531 502025000447 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000448 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025000449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025000450 N-terminal plug; other site 502025000451 ligand-binding site [chemical binding]; other site 502025000452 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025000453 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 502025000454 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 502025000455 dimerization interface [polypeptide binding]; other site 502025000456 domain crossover interface; other site 502025000457 redox-dependent activation switch; other site 502025000458 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 502025000459 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 502025000460 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025000461 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025000462 catalytic residue [active] 502025000463 Cytochrome c; Region: Cytochrom_C; cl11414 502025000464 putative efflux protein, MATE family; Region: matE; TIGR00797 502025000465 MatE; Region: MatE; cl10513 502025000466 MatE; Region: MatE; cl10513 502025000467 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025000468 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025000469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000470 binding surface 502025000471 TPR motif; other site 502025000472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000473 binding surface 502025000474 TPR motif; other site 502025000475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000476 TPR motif; other site 502025000477 TPR repeat; Region: TPR_11; pfam13414 502025000478 binding surface 502025000479 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025000480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000481 TPR motif; other site 502025000482 binding surface 502025000483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000484 binding surface 502025000485 TPR motif; other site 502025000486 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 502025000487 substrate binding site [chemical binding]; other site 502025000488 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 502025000489 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 502025000490 substrate binding site [chemical binding]; other site 502025000491 ligand binding site [chemical binding]; other site 502025000492 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 502025000493 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 502025000494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000495 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 502025000496 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 502025000497 Family description; Region: UvrD_C_2; cl15862 502025000498 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000499 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000500 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000501 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000502 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000504 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000508 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000509 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000510 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000511 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000515 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025000516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000522 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 502025000523 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025000524 active site 502025000525 metal binding site [ion binding]; metal-binding site 502025000526 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 502025000527 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025000528 metal ion-dependent adhesion site (MIDAS); other site 502025000529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025000530 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 502025000531 active site 502025000532 FMN binding site [chemical binding]; other site 502025000533 substrate binding site [chemical binding]; other site 502025000534 putative catalytic residue [active] 502025000535 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025000536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025000537 ATP binding site [chemical binding]; other site 502025000538 putative Mg++ binding site [ion binding]; other site 502025000539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025000540 nucleotide binding region [chemical binding]; other site 502025000541 ATP-binding site [chemical binding]; other site 502025000542 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 502025000543 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 502025000544 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 502025000545 heme-binding site [chemical binding]; other site 502025000546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 502025000547 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 502025000548 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000549 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025000550 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 502025000551 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025000552 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 502025000553 Walker A/P-loop; other site 502025000554 ATP binding site [chemical binding]; other site 502025000555 Q-loop/lid; other site 502025000556 ABC transporter signature motif; other site 502025000557 Walker B; other site 502025000558 D-loop; other site 502025000559 H-loop/switch region; other site 502025000560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025000561 catalytic core [active] 502025000562 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 502025000563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000564 FeS/SAM binding site; other site 502025000565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000566 Walker A motif; other site 502025000567 ATP binding site [chemical binding]; other site 502025000568 Walker B motif; other site 502025000569 arginine finger; other site 502025000570 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 502025000571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000572 Walker A motif; other site 502025000573 ATP binding site [chemical binding]; other site 502025000574 Walker B motif; other site 502025000575 arginine finger; other site 502025000576 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025000577 structural tetrad; other site 502025000578 Protein of unknown function DUF72; Region: DUF72; cl00777 502025000579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000581 active site 502025000582 ATP binding site [chemical binding]; other site 502025000583 substrate binding site [chemical binding]; other site 502025000584 activation loop (A-loop); other site 502025000585 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 502025000586 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025000587 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025000588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025000589 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 502025000590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000591 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025000592 Nucleotide binding site [chemical binding]; other site 502025000593 P loop; other site 502025000594 Chain length determinant protein; Region: Wzz; cl15801 502025000595 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 502025000596 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 502025000597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025000598 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025000599 anti sigma factor interaction site; other site 502025000600 regulatory phosphorylation site [posttranslational modification]; other site 502025000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025000602 Bacterial sugar transferase; Region: Bac_transf; cl00939 502025000603 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025000604 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025000605 SLBB domain; Region: SLBB; pfam10531 502025000606 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 502025000607 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 502025000608 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 502025000609 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 502025000610 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 502025000611 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 502025000612 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025000613 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025000614 dimer interface [polypeptide binding]; other site 502025000615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000616 catalytic residue [active] 502025000617 Esterase/lipase [General function prediction only]; Region: COG1647 502025000618 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000619 phosphopeptide binding site; other site 502025000620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000621 metal binding site [ion binding]; metal-binding site 502025000622 active site 502025000623 I-site; other site 502025000624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025000625 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 502025000626 putative ADP-binding pocket [chemical binding]; other site 502025000627 MatE; Region: MatE; cl10513 502025000628 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025000629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000630 active site 502025000631 phosphorylation site [posttranslational modification] 502025000632 intermolecular recognition site; other site 502025000633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025000634 dimerization interface [polypeptide binding]; other site 502025000635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025000636 dimer interface [polypeptide binding]; other site 502025000637 phosphorylation site [posttranslational modification] 502025000638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000639 ATP binding site [chemical binding]; other site 502025000640 Mg2+ binding site [ion binding]; other site 502025000641 G-X-G motif; other site 502025000642 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000644 active site 502025000645 phosphorylation site [posttranslational modification] 502025000646 intermolecular recognition site; other site 502025000647 dimerization interface [polypeptide binding]; other site 502025000648 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000649 active site 502025000650 ATP binding site [chemical binding]; other site 502025000651 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000652 substrate binding site [chemical binding]; other site 502025000653 activation loop (A-loop); other site 502025000654 Predicted ATPase [General function prediction only]; Region: COG3899 502025000655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000656 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 502025000657 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 502025000658 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 502025000659 homodimer interface [polypeptide binding]; other site 502025000660 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 502025000661 active site pocket [active] 502025000662 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025000663 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 502025000664 active site 502025000665 catalytic triad [active] 502025000666 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 502025000667 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025000668 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025000669 catalytic residues [active] 502025000670 regulatory ATPase RavA; Provisional; Region: PRK13531 502025000671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000672 Walker A motif; other site 502025000673 ATP binding site [chemical binding]; other site 502025000674 Walker B motif; other site 502025000675 arginine finger; other site 502025000676 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025000677 metal ion-dependent adhesion site (MIDAS); other site 502025000678 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 502025000679 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000680 dimer interface [polypeptide binding]; other site 502025000681 active site 502025000682 CoA binding pocket [chemical binding]; other site 502025000683 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 502025000684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000685 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025000686 Walker A motif; other site 502025000687 ATP binding site [chemical binding]; other site 502025000688 Walker B motif; other site 502025000689 arginine finger; other site 502025000690 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 502025000691 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 502025000692 hypothetical protein; Reviewed; Region: PRK09588 502025000693 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 502025000694 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 502025000695 putative active site [active] 502025000696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000697 binding surface 502025000698 TPR motif; other site 502025000699 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025000700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025000701 TPR motif; other site 502025000702 binding surface 502025000703 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 502025000704 Na binding site [ion binding]; other site 502025000705 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 502025000706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025000707 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025000708 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025000709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025000710 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 502025000711 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025000712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025000714 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025000715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000716 Walker A motif; other site 502025000717 ATP binding site [chemical binding]; other site 502025000718 Walker B motif; other site 502025000719 arginine finger; other site 502025000720 Helix-turn-helix domains; Region: HTH; cl00088 502025000721 Competence protein A; Region: Competence_A; pfam11104 502025000722 Cell division protein FtsA; Region: FtsA; cl11496 502025000723 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 502025000724 Pilus assembly protein, PilO; Region: PilO; cl01234 502025000725 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025000726 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 502025000727 Secretin and TonB N terminus short domain; Region: STN; cl06624 502025000728 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025000729 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 502025000730 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 502025000731 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 502025000732 ADP binding site [chemical binding]; other site 502025000733 magnesium binding site [ion binding]; other site 502025000734 putative shikimate binding site; other site 502025000735 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 502025000736 active site 502025000737 dimer interface [polypeptide binding]; other site 502025000738 metal binding site [ion binding]; metal-binding site 502025000739 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 502025000740 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 502025000741 trimer interface [polypeptide binding]; other site 502025000742 active site 502025000743 dimer interface [polypeptide binding]; other site 502025000744 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 502025000745 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025000746 carboxyltransferase (CT) interaction site; other site 502025000747 biotinylation site [posttranslational modification]; other site 502025000748 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025000749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025000750 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025000751 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 502025000752 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025000753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000754 binding surface 502025000755 TPR motif; other site 502025000756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000757 TPR repeat; Region: TPR_11; pfam13414 502025000758 binding surface 502025000759 TPR motif; other site 502025000760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025000761 dimerization interface [polypeptide binding]; other site 502025000762 DNA binding residues [nucleotide binding] 502025000763 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 502025000764 FG-GAP repeat; Region: FG-GAP; cl15299 502025000765 FG-GAP repeat; Region: FG-GAP; cl15299 502025000766 FG-GAP repeat; Region: FG-GAP; cl15299 502025000767 FG-GAP repeat; Region: FG-GAP; cl15299 502025000768 FG-GAP repeat; Region: FG-GAP; cl15299 502025000769 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000770 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000771 active site 502025000772 ATP binding site [chemical binding]; other site 502025000773 substrate binding site [chemical binding]; other site 502025000774 activation loop (A-loop); other site 502025000775 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000776 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025000777 BolA-like protein; Region: BolA; cl00386 502025000778 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025000779 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025000780 NAD(P) binding site [chemical binding]; other site 502025000781 catalytic residues [active] 502025000782 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 502025000783 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025000784 Zn2+ binding site [ion binding]; other site 502025000785 Mg2+ binding site [ion binding]; other site 502025000786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025000787 dimerization interface [polypeptide binding]; other site 502025000788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025000789 dimer interface [polypeptide binding]; other site 502025000790 phosphorylation site [posttranslational modification] 502025000791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000792 ATP binding site [chemical binding]; other site 502025000793 G-X-G motif; other site 502025000794 DNA-binding response regulator CreB; Provisional; Region: PRK11083 502025000795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000796 active site 502025000797 phosphorylation site [posttranslational modification] 502025000798 intermolecular recognition site; other site 502025000799 dimerization interface [polypeptide binding]; other site 502025000800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025000801 DNA binding site [nucleotide binding] 502025000802 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 502025000803 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 502025000804 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025000805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025000806 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025000807 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025000808 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025000809 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025000810 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025000811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025000812 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000813 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025000814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000816 active site 502025000817 ATP binding site [chemical binding]; other site 502025000818 substrate binding site [chemical binding]; other site 502025000819 activation loop (A-loop); other site 502025000820 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000822 active site 502025000823 phosphorylation site [posttranslational modification] 502025000824 intermolecular recognition site; other site 502025000825 dimerization interface [polypeptide binding]; other site 502025000826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000827 metal binding site [ion binding]; metal-binding site 502025000828 active site 502025000829 I-site; other site 502025000830 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000831 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000832 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000833 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 502025000834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000835 FeS/SAM binding site; other site 502025000836 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 502025000837 RNA polymerase sigma factor; Provisional; Region: PRK11922 502025000838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000839 DNA binding residues [nucleotide binding] 502025000840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025000841 active site 502025000842 phosphorylation site [posttranslational modification] 502025000843 intermolecular recognition site; other site 502025000844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025000845 phosphorylation site [posttranslational modification] 502025000846 dimer interface [polypeptide binding]; other site 502025000847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000848 ATP binding site [chemical binding]; other site 502025000849 Mg2+ binding site [ion binding]; other site 502025000850 G-X-G motif; other site 502025000851 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000853 active site 502025000854 phosphorylation site [posttranslational modification] 502025000855 intermolecular recognition site; other site 502025000856 dimerization interface [polypeptide binding]; other site 502025000857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000858 Walker A motif; other site 502025000859 ATP binding site [chemical binding]; other site 502025000860 Walker B motif; other site 502025000861 arginine finger; other site 502025000862 Helix-turn-helix domains; Region: HTH; cl00088 502025000863 isocitrate dehydrogenase; Validated; Region: PRK06451 502025000864 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 502025000865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000866 Ligand Binding Site [chemical binding]; other site 502025000867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000868 Ligand Binding Site [chemical binding]; other site 502025000869 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000870 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000871 active site 502025000872 ATP binding site [chemical binding]; other site 502025000873 substrate binding site [chemical binding]; other site 502025000874 activation loop (A-loop); other site 502025000875 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000876 glycerol kinase; Provisional; Region: glpK; PRK00047 502025000877 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 502025000878 N- and C-terminal domain interface [polypeptide binding]; other site 502025000879 active site 502025000880 MgATP binding site [chemical binding]; other site 502025000881 catalytic site [active] 502025000882 metal binding site [ion binding]; metal-binding site 502025000883 glycerol binding site [chemical binding]; other site 502025000884 homotetramer interface [polypeptide binding]; other site 502025000885 homodimer interface [polypeptide binding]; other site 502025000886 FBP binding site [chemical binding]; other site 502025000887 protein IIAGlc interface [polypeptide binding]; other site 502025000888 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025000889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000891 DNA binding residues [nucleotide binding] 502025000892 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025000893 Transglycosylase; Region: Transgly; cl07896 502025000894 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025000895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025000896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000897 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 502025000898 NAD(P) binding site [chemical binding]; other site 502025000899 active site 502025000900 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 502025000901 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025000902 inhibitor-cofactor binding pocket; inhibition site 502025000903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000904 catalytic residue [active] 502025000905 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025000906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000907 Walker A/P-loop; other site 502025000908 ATP binding site [chemical binding]; other site 502025000909 Q-loop/lid; other site 502025000910 ABC transporter signature motif; other site 502025000911 Walker B; other site 502025000912 D-loop; other site 502025000913 H-loop/switch region; other site 502025000914 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025000915 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 502025000916 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025000917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025000918 Walker A/P-loop; other site 502025000919 ATP binding site [chemical binding]; other site 502025000920 Q-loop/lid; other site 502025000921 ABC transporter signature motif; other site 502025000922 Walker B; other site 502025000923 D-loop; other site 502025000924 H-loop/switch region; other site 502025000925 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 502025000926 Helix-turn-helix domains; Region: HTH; cl00088 502025000927 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025000928 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025000929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000930 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 502025000931 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025000933 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025000934 ligand binding site [chemical binding]; other site 502025000935 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025000936 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 502025000937 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 502025000938 Septum formation initiator; Region: DivIC; cl11433 502025000939 GAF domain; Region: GAF; cl15785 502025000940 GAF domain; Region: GAF_2; pfam13185 502025000941 GAF domain; Region: GAF; cl15785 502025000942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000943 metal binding site [ion binding]; metal-binding site 502025000944 active site 502025000945 I-site; other site 502025000946 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025000947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000948 NAD(P) binding site [chemical binding]; other site 502025000949 active site 502025000950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025000951 Coenzyme A binding pocket [chemical binding]; other site 502025000952 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025000953 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025000954 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025000955 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025000956 Walker A/P-loop; other site 502025000957 ATP binding site [chemical binding]; other site 502025000958 Q-loop/lid; other site 502025000959 ABC transporter signature motif; other site 502025000960 Walker B; other site 502025000961 D-loop; other site 502025000962 H-loop/switch region; other site 502025000963 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025000964 FtsX-like permease family; Region: FtsX; cl15850 502025000965 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025000966 FtsX-like permease family; Region: FtsX; cl15850 502025000967 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025000968 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025000969 macrolide transporter subunit MacA; Provisional; Region: PRK11578 502025000970 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000971 Ligand Binding Site [chemical binding]; other site 502025000972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000973 Ligand Binding Site [chemical binding]; other site 502025000974 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 502025000975 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025000976 ATP binding site [chemical binding]; other site 502025000977 Mg++ binding site [ion binding]; other site 502025000978 motif III; other site 502025000979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025000980 nucleotide binding region [chemical binding]; other site 502025000981 ATP-binding site [chemical binding]; other site 502025000982 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 502025000983 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 502025000984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025000985 active site 502025000986 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 502025000987 YceI-like domain; Region: YceI; cl01001 502025000988 YceI-like domain; Region: YceI; cl01001 502025000989 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 502025000990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025000991 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 502025000992 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 502025000993 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 502025000994 ligand binding site; other site 502025000995 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 502025000996 TPP-binding site [chemical binding]; other site 502025000997 dimer interface [polypeptide binding]; other site 502025000998 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 502025000999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 502025001000 PYR/PP interface [polypeptide binding]; other site 502025001001 dimer interface [polypeptide binding]; other site 502025001002 TPP binding site [chemical binding]; other site 502025001003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025001004 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 502025001005 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001006 inhibitor-cofactor binding pocket; inhibition site 502025001007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001008 catalytic residue [active] 502025001009 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 502025001010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001011 NAD(P) binding site [chemical binding]; other site 502025001012 active site 502025001013 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025001014 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 502025001015 NeuB family; Region: NeuB; cl00496 502025001016 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 502025001017 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 502025001018 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025001019 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 502025001020 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025001021 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025001022 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025001023 active site 502025001024 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001025 protein binding site [polypeptide binding]; other site 502025001026 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001027 protein binding site [polypeptide binding]; other site 502025001028 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001029 protein binding site [polypeptide binding]; other site 502025001030 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025001031 putative substrate binding region [chemical binding]; other site 502025001032 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025001033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025001034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025001035 FecR protein; Region: FecR; pfam04773 502025001036 glucose-1-dehydrogenase; Provisional; Region: PRK08936 502025001037 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 502025001038 NAD binding site [chemical binding]; other site 502025001039 homodimer interface [polypeptide binding]; other site 502025001040 active site 502025001041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 502025001042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025001043 Coenzyme A binding pocket [chemical binding]; other site 502025001044 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 502025001045 FAD binding domain; Region: FAD_binding_4; pfam01565 502025001046 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 502025001047 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 502025001048 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 502025001049 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025001050 Pectinesterase; Region: Pectinesterase; cl01911 502025001051 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 502025001052 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001053 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001054 active site 502025001055 ATP binding site [chemical binding]; other site 502025001056 substrate binding site [chemical binding]; other site 502025001057 activation loop (A-loop); other site 502025001058 TPR repeat; Region: TPR_11; pfam13414 502025001059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001060 TPR motif; other site 502025001061 binding surface 502025001062 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 502025001063 putative ligand binding site [chemical binding]; other site 502025001064 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025001065 active site 502025001066 HIGH motif; other site 502025001067 nucleotide binding site [chemical binding]; other site 502025001068 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025001069 active site 502025001070 KMSKS motif; other site 502025001071 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025001072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001073 S-adenosylmethionine binding site [chemical binding]; other site 502025001074 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025001075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001076 S-adenosylmethionine binding site [chemical binding]; other site 502025001077 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025001078 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001079 TPR repeat; Region: TPR_11; pfam13414 502025001080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001081 binding surface 502025001082 TPR motif; other site 502025001083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001085 active site 502025001086 ATP binding site [chemical binding]; other site 502025001087 substrate binding site [chemical binding]; other site 502025001088 activation loop (A-loop); other site 502025001089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025001091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001092 homodimer interface [polypeptide binding]; other site 502025001093 catalytic residue [active] 502025001094 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001095 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025001096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001097 binding surface 502025001098 TPR motif; other site 502025001099 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 502025001100 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 502025001101 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025001102 catalytic residue [active] 502025001103 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 502025001104 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 502025001105 putative active site pocket [active] 502025001106 4-fold oligomerization interface [polypeptide binding]; other site 502025001107 metal binding residues [ion binding]; metal-binding site 502025001108 3-fold/trimer interface [polypeptide binding]; other site 502025001109 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 502025001110 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 502025001111 putative active site [active] 502025001112 oxyanion strand; other site 502025001113 catalytic triad [active] 502025001114 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 502025001115 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 502025001116 catalytic residues [active] 502025001117 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 502025001118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001119 Family description; Region: UvrD_C_2; cl15862 502025001120 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 502025001121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001122 PA14 domain; Region: PA14; cl08459 502025001123 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 502025001124 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 502025001125 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025001126 active site 502025001127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001128 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 502025001129 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 502025001130 dimer interface [polypeptide binding]; other site 502025001131 decamer (pentamer of dimers) interface [polypeptide binding]; other site 502025001132 catalytic triad [active] 502025001133 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025001134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001135 S-adenosylmethionine binding site [chemical binding]; other site 502025001136 Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653 502025001137 SEC-C motif; Region: SEC-C; pfam02810 502025001138 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 502025001139 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 502025001140 ANP binding site [chemical binding]; other site 502025001141 Substrate Binding Site II [chemical binding]; other site 502025001142 Substrate Binding Site I [chemical binding]; other site 502025001143 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025001144 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025001145 HSP70 interaction site [polypeptide binding]; other site 502025001146 ornithine carbamoyltransferase; Provisional; Region: PRK00779 502025001147 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 502025001148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001149 acetylornithine aminotransferase; Provisional; Region: PRK02627 502025001150 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001151 inhibitor-cofactor binding pocket; inhibition site 502025001152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001153 catalytic residue [active] 502025001154 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025001156 Walker A motif; other site 502025001157 ATP binding site [chemical binding]; other site 502025001158 Walker B motif; other site 502025001159 arginine finger; other site 502025001160 Helix-turn-helix domains; Region: HTH; cl00088 502025001161 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 502025001162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 502025001163 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 502025001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 502025001165 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025001166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025001167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001168 Walker A/P-loop; other site 502025001169 ATP binding site [chemical binding]; other site 502025001170 Q-loop/lid; other site 502025001171 ABC transporter signature motif; other site 502025001172 Walker B; other site 502025001173 D-loop; other site 502025001174 H-loop/switch region; other site 502025001175 Double zinc ribbon; Region: DZR; pfam12773 502025001176 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025001177 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025001178 cyclase homology domain; Region: CHD; cd07302 502025001179 nucleotidyl binding site; other site 502025001180 metal binding site [ion binding]; metal-binding site 502025001181 dimer interface [polypeptide binding]; other site 502025001182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001184 binding surface 502025001185 TPR motif; other site 502025001186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001189 binding surface 502025001190 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001191 TPR motif; other site 502025001192 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 502025001193 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025001194 short chain dehydrogenase; Validated; Region: PRK05855 502025001195 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025001196 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025001197 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025001198 nuclear protein UL24; Provisional; Region: PHA03215 502025001199 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025001200 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 502025001201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001202 Walker A/P-loop; other site 502025001203 ATP binding site [chemical binding]; other site 502025001204 Q-loop/lid; other site 502025001205 ABC transporter signature motif; other site 502025001206 Walker B; other site 502025001207 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 502025001208 ABC-ATPase subunit interface; other site 502025001209 dimer interface [polypeptide binding]; other site 502025001210 putative PBP binding regions; other site 502025001211 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001212 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 502025001213 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025001214 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025001215 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 502025001216 intersubunit interface [polypeptide binding]; other site 502025001217 Protein of unknown function (DUF525); Region: DUF525; cl01119 502025001218 GtrA-like protein; Region: GtrA; cl00971 502025001219 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 502025001220 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025001221 Ligand binding site; other site 502025001222 Putative Catalytic site; other site 502025001223 DXD motif; other site 502025001224 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025001225 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025001226 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 502025001227 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 502025001228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001229 active site 502025001230 ATP binding site [chemical binding]; other site 502025001231 substrate binding site [chemical binding]; other site 502025001232 activation loop (A-loop); other site 502025001233 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 502025001234 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 502025001235 gamma-glutamyl kinase; Provisional; Region: PRK05429 502025001236 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 502025001237 nucleotide binding site [chemical binding]; other site 502025001238 homotetrameric interface [polypeptide binding]; other site 502025001239 putative phosphate binding site [ion binding]; other site 502025001240 putative allosteric binding site; other site 502025001241 PUA domain; Region: PUA; cl00607 502025001242 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 502025001243 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 502025001244 putative catalytic cysteine [active] 502025001245 Oligomerisation domain; Region: Oligomerisation; cl00519 502025001246 Cytochrome c; Region: Cytochrom_C; cl11414 502025001247 FAD dependent oxidoreductase; Region: DAO; pfam01266 502025001248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001249 threonine synthase; Validated; Region: PRK06260 502025001250 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 502025001251 homodimer interface [polypeptide binding]; other site 502025001252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001253 catalytic residue [active] 502025001254 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025001255 Na binding site [ion binding]; other site 502025001256 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 502025001257 active site 502025001258 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 502025001259 dimer interface [polypeptide binding]; other site 502025001260 non-prolyl cis peptide bond; other site 502025001261 insertion regions; other site 502025001262 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 502025001263 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 502025001264 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025001265 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001267 active site 502025001268 ATP binding site [chemical binding]; other site 502025001269 substrate binding site [chemical binding]; other site 502025001270 activation loop (A-loop); other site 502025001271 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 502025001272 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 502025001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001274 FeS/SAM binding site; other site 502025001275 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025001276 FG-GAP repeat; Region: FG-GAP; cl15299 502025001277 FG-GAP repeat; Region: FG-GAP; cl15299 502025001278 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 502025001279 Ferredoxin [Energy production and conversion]; Region: COG1146 502025001280 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 502025001281 YhhN-like protein; Region: YhhN; cl01505 502025001282 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025001283 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025001285 Coenzyme A binding pocket [chemical binding]; other site 502025001286 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025001287 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025001288 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025001289 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025001290 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025001291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025001292 active site 502025001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001294 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025001295 FAD binding domain; Region: FAD_binding_4; pfam01565 502025001296 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025001297 TraB family; Region: TraB; cl12050 502025001298 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025001299 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 502025001300 active site 502025001301 HEAT repeats; Region: HEAT_2; pfam13646 502025001302 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 502025001303 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025001304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025001305 substrate binding site [chemical binding]; other site 502025001306 oxyanion hole (OAH) forming residues; other site 502025001307 trimer interface [polypeptide binding]; other site 502025001308 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025001309 AMP-binding enzyme; Region: AMP-binding; cl15778 502025001310 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 502025001311 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025001312 Na binding site [ion binding]; other site 502025001313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001315 NAD(P) binding site [chemical binding]; other site 502025001316 active site 502025001317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025001318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001319 NAD(P) binding site [chemical binding]; other site 502025001320 active site 502025001321 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025001322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001323 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 502025001324 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 502025001325 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 502025001326 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 502025001327 catalytic residue [active] 502025001328 putative FPP diphosphate binding site; other site 502025001329 putative FPP binding hydrophobic cleft; other site 502025001330 dimer interface [polypeptide binding]; other site 502025001331 putative IPP diphosphate binding site; other site 502025001332 phage shock protein A; Region: phageshock_pspA; TIGR02977 502025001333 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025001334 protein binding site [polypeptide binding]; other site 502025001335 PilZ domain; Region: PilZ; cl01260 502025001336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025001337 active site 502025001338 phosphorylation site [posttranslational modification] 502025001339 intermolecular recognition site; other site 502025001340 dimerization interface [polypeptide binding]; other site 502025001341 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001342 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001343 active site 502025001344 ATP binding site [chemical binding]; other site 502025001345 substrate binding site [chemical binding]; other site 502025001346 activation loop (A-loop); other site 502025001347 Predicted ATPase [General function prediction only]; Region: COG3899 502025001348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001349 14-3-3 domain; Region: 14-3-3; cl02098 502025001350 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 502025001351 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025001352 dimer interface [polypeptide binding]; other site 502025001353 active site 502025001354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025001355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025001356 active site 502025001357 metal binding site [ion binding]; metal-binding site 502025001358 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001359 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001360 active site 502025001361 ATP binding site [chemical binding]; other site 502025001362 substrate binding site [chemical binding]; other site 502025001363 activation loop (A-loop); other site 502025001364 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025001365 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 502025001366 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025001367 copper exporting ATPase; Provisional; Region: copA; PRK10671 502025001368 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 502025001369 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025001370 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 502025001371 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 502025001372 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025001373 Tetratricopeptide repeat; Region: TPR_6; pfam13174 502025001374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001375 Protein kinase domain; Region: Pkinase; pfam00069 502025001376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001377 active site 502025001378 ATP binding site [chemical binding]; other site 502025001379 substrate binding site [chemical binding]; other site 502025001380 activation loop (A-loop); other site 502025001381 Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642 502025001382 UbiA prenyltransferase family; Region: UbiA; cl00337 502025001383 Protein of unknown function (DUF420); Region: DUF420; cl00989 502025001384 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025001385 biotin synthase; Region: bioB; TIGR00433 502025001386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001387 FeS/SAM binding site; other site 502025001388 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 502025001389 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 502025001390 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 502025001391 quinone interaction residues [chemical binding]; other site 502025001392 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 502025001393 active site 502025001394 catalytic residues [active] 502025001395 FMN binding site [chemical binding]; other site 502025001396 substrate binding site [chemical binding]; other site 502025001397 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025001398 DTAP/Switch II; other site 502025001399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025001400 Domain of unknown function (DUF329); Region: DUF329; cl01144 502025001401 PilZ domain; Region: PilZ; cl01260 502025001402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025001403 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025001404 Ligand binding site; other site 502025001405 Putative Catalytic site; other site 502025001406 DXD motif; other site 502025001407 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 502025001408 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025001409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025001410 Walker A motif; other site 502025001411 ATP binding site [chemical binding]; other site 502025001412 Walker B motif; other site 502025001413 arginine finger; other site 502025001414 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025001415 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025001416 Aerotolerance regulator N-terminal; Region: BatA; cl06567 502025001417 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025001418 metal ion-dependent adhesion site (MIDAS); other site 502025001419 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025001420 metal ion-dependent adhesion site (MIDAS); other site 502025001421 Oxygen tolerance; Region: BatD; pfam13584 502025001422 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 502025001423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001424 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 502025001425 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 502025001426 Rdx family; Region: Rdx; cl01407 502025001427 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025001428 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 502025001429 TPR repeat; Region: TPR_11; pfam13414 502025001430 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 502025001431 RNA binding site [nucleotide binding]; other site 502025001432 domain interface; other site 502025001433 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 502025001434 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 502025001435 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025001436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001438 active site 502025001439 ATP binding site [chemical binding]; other site 502025001440 substrate binding site [chemical binding]; other site 502025001441 activation loop (A-loop); other site 502025001442 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025001443 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025001444 Sulfatase; Region: Sulfatase; cl10460 502025001445 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 502025001446 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 502025001447 dimerization interface [polypeptide binding]; other site 502025001448 active site 502025001449 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 502025001450 RNA binding site [nucleotide binding]; other site 502025001451 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 502025001452 RNA binding site [nucleotide binding]; other site 502025001453 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025001454 RNA binding site [nucleotide binding]; other site 502025001455 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 502025001456 RNA binding site [nucleotide binding]; other site 502025001457 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001458 active site 502025001459 ATP binding site [chemical binding]; other site 502025001460 substrate binding site [chemical binding]; other site 502025001461 activation loop (A-loop); other site 502025001462 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 502025001463 elongation factor G; Reviewed; Region: PRK12740 502025001464 G1 box; other site 502025001465 putative GEF interaction site [polypeptide binding]; other site 502025001466 GTP/Mg2+ binding site [chemical binding]; other site 502025001467 Switch I region; other site 502025001468 G2 box; other site 502025001469 G3 box; other site 502025001470 Switch II region; other site 502025001471 G4 box; other site 502025001472 G5 box; other site 502025001473 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 502025001474 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 502025001475 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025001476 AAA domain; Region: AAA_25; pfam13481 502025001477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001478 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025001479 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001480 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001481 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025001482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025001483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025001484 active site 502025001485 phosphorylation site [posttranslational modification] 502025001486 intermolecular recognition site; other site 502025001487 dimerization interface [polypeptide binding]; other site 502025001488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025001489 DNA binding site [nucleotide binding] 502025001490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025001491 dimer interface [polypeptide binding]; other site 502025001492 phosphorylation site [posttranslational modification] 502025001493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025001494 ATP binding site [chemical binding]; other site 502025001495 Mg2+ binding site [ion binding]; other site 502025001496 G-X-G motif; other site 502025001497 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025001498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025001499 active site 502025001500 catalytic tetrad [active] 502025001501 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025001502 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 502025001503 cleavage site 502025001504 active site 502025001505 substrate binding sites [chemical binding]; other site 502025001506 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025001507 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025001508 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025001509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001511 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 502025001512 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 502025001513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025001514 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025001515 active site 502025001516 catalytic tetrad [active] 502025001517 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 502025001518 4Fe-4S binding domain; Region: Fer4_5; pfam12801 502025001519 4Fe-4S binding domain; Region: Fer4_5; pfam12801 502025001520 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 502025001521 4Fe-4S binding domain; Region: Fer4; cl02805 502025001522 4Fe-4S binding domain; Region: Fer4; cl02805 502025001523 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025001524 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025001525 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 502025001526 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001527 inhibitor-cofactor binding pocket; inhibition site 502025001528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001529 catalytic residue [active] 502025001530 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 502025001531 active site 502025001532 metal binding site [ion binding]; metal-binding site 502025001533 ribonuclease PH; Reviewed; Region: rph; PRK00173 502025001534 Ribonuclease PH; Region: RNase_PH_bact; cd11362 502025001535 hexamer interface [polypeptide binding]; other site 502025001536 active site 502025001537 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 502025001538 active site 502025001539 dimerization interface [polypeptide binding]; other site 502025001540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001541 non-specific DNA binding site [nucleotide binding]; other site 502025001542 salt bridge; other site 502025001543 sequence-specific DNA binding site [nucleotide binding]; other site 502025001544 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001545 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001546 active site 502025001547 ATP binding site [chemical binding]; other site 502025001548 substrate binding site [chemical binding]; other site 502025001549 activation loop (A-loop); other site 502025001550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001551 TPR repeat; Region: TPR_11; pfam13414 502025001552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001553 binding surface 502025001554 TPR motif; other site 502025001555 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001556 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001557 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001558 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025001559 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025001560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001561 non-specific DNA binding site [nucleotide binding]; other site 502025001562 salt bridge; other site 502025001563 sequence-specific DNA binding site [nucleotide binding]; other site 502025001564 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001565 putative active site pocket [active] 502025001566 dimerization interface [polypeptide binding]; other site 502025001567 putative catalytic residue [active] 502025001568 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001569 excinuclease ABC, A subunit; Region: uvra; TIGR00630 502025001570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025001571 active site 502025001572 DNA binding site [nucleotide binding] 502025001573 Int/Topo IB signature motif; other site 502025001574 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001575 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025001576 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025001577 catalytic residues [active] 502025001578 catalytic nucleophile [active] 502025001579 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025001580 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025001581 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025001582 Synaptic Site I dimer interface [polypeptide binding]; other site 502025001583 DNA binding site [nucleotide binding] 502025001584 Recombinase; Region: Recombinase; pfam07508 502025001585 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001586 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025001587 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025001588 FG-GAP repeat; Region: FG-GAP; cl15299 502025001589 FG-GAP repeat; Region: FG-GAP; cl15299 502025001590 FG-GAP repeat; Region: FG-GAP; cl15299 502025001591 FG-GAP repeat; Region: FG-GAP; cl15299 502025001592 FG-GAP repeat; Region: FG-GAP; cl15299 502025001593 FG-GAP repeat; Region: FG-GAP; cl15299 502025001594 FG-GAP repeat; Region: FG-GAP; cl15299 502025001595 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 502025001596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001597 PglZ domain; Region: PglZ; pfam08665 502025001598 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025001599 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025001600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001601 ATP binding site [chemical binding]; other site 502025001602 putative Mg++ binding site [ion binding]; other site 502025001603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001604 nucleotide binding region [chemical binding]; other site 502025001605 ATP-binding site [chemical binding]; other site 502025001606 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025001607 catalytic site [active] 502025001608 putative active site [active] 502025001609 putative substrate binding site [chemical binding]; other site 502025001610 Domain of unknown function (DUF955); Region: DUF955; cl01076 502025001611 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 502025001612 ADP-ribose binding site [chemical binding]; other site 502025001613 AAA domain; Region: AAA_33; pfam13671 502025001614 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 502025001615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001618 TPR motif; other site 502025001619 binding surface 502025001620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001623 binding surface 502025001624 TPR motif; other site 502025001625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001628 TPR motif; other site 502025001629 binding surface 502025001630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025001632 short chain dehydrogenase; Provisional; Region: PRK06523 502025001633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001634 NAD(P) binding site [chemical binding]; other site 502025001635 active site 502025001636 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025001637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025001638 Helix-turn-helix domains; Region: HTH; cl00088 502025001639 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 502025001640 putative effector binding pocket; other site 502025001641 putative dimerization interface [polypeptide binding]; other site 502025001642 Disintegrin; Region: Disintegrin; cl10507 502025001643 Disintegrin; Region: Disintegrin; cl10507 502025001644 Disintegrin; Region: Disintegrin; cl10507 502025001645 Disintegrin; Region: Disintegrin; cl10507 502025001646 Disintegrin; Region: Disintegrin; cl10507 502025001647 Disintegrin; Region: Disintegrin; cl10507 502025001648 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001649 catalytic residues [active] 502025001650 catalytic nucleophile [active] 502025001651 Recombinase; Region: Recombinase; pfam07508 502025001652 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001653 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001654 CHC2 zinc finger; Region: zf-CHC2; cl15369 502025001655 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025001656 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 502025001657 active site 502025001658 metal binding site [ion binding]; metal-binding site 502025001659 interdomain interaction site; other site 502025001660 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 502025001661 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 502025001662 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025001663 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001664 active site 502025001665 catalytic site [active] 502025001666 substrate binding site [chemical binding]; other site 502025001667 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025001668 active site 502025001669 DNA binding site [nucleotide binding] 502025001670 Int/Topo IB signature motif; other site 502025001671 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025001672 Terminase-like family; Region: Terminase_6; pfam03237 502025001673 Phage-related protein [Function unknown]; Region: COG4695; cl01923 502025001674 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 502025001675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001677 Phage capsid family; Region: Phage_capsid; pfam05065 502025001678 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025001679 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025001680 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025001681 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025001682 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 502025001683 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 502025001684 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025001685 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025001686 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025001687 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 502025001688 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 502025001689 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001690 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001691 putative active site pocket [active] 502025001692 dimerization interface [polypeptide binding]; other site 502025001693 putative catalytic residue [active] 502025001694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001695 non-specific DNA binding site [nucleotide binding]; other site 502025001696 salt bridge; other site 502025001697 sequence-specific DNA binding site [nucleotide binding]; other site 502025001698 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025001699 phosphopeptide binding site; other site 502025001700 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001701 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001702 active site 502025001703 ATP binding site [chemical binding]; other site 502025001704 substrate binding site [chemical binding]; other site 502025001705 activation loop (A-loop); other site 502025001706 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025001707 FG-GAP repeat; Region: FG-GAP; cl15299 502025001708 FG-GAP repeat; Region: FG-GAP; cl15299 502025001709 FG-GAP repeat; Region: FG-GAP; cl15299 502025001710 FG-GAP repeat; Region: FG-GAP; cl15299 502025001711 FG-GAP repeat; Region: FG-GAP; cl15299 502025001712 FG-GAP repeat; Region: FG-GAP; cl15299 502025001713 FG-GAP repeat; Region: FG-GAP; cl15299 502025001714 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001715 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025001716 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025001717 active site 502025001718 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001719 active site 502025001720 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025001721 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025001722 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 502025001723 putative NADP binding site [chemical binding]; other site 502025001724 active site 502025001725 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 502025001726 Family description; Region: VCBS; pfam13517 502025001727 Family description; Region: VCBS; pfam13517 502025001728 FG-GAP repeat; Region: FG-GAP; cl15299 502025001729 Family description; Region: VCBS; pfam13517 502025001730 Family description; Region: VCBS; pfam13517 502025001731 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025001732 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 502025001733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025001734 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025001735 active site 502025001736 metal binding site [ion binding]; metal-binding site 502025001737 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025001738 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 502025001739 Phage Tail Collar Domain; Region: Collar; pfam07484 502025001740 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001741 catalytic residues [active] 502025001742 catalytic nucleophile [active] 502025001743 Recombinase; Region: Recombinase; pfam07508 502025001744 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001745 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001746 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025001747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001748 ATP binding site [chemical binding]; other site 502025001749 putative Mg++ binding site [ion binding]; other site 502025001750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001751 nucleotide binding region [chemical binding]; other site 502025001752 ATP-binding site [chemical binding]; other site 502025001753 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025001754 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001755 DEAD_2; Region: DEAD_2; pfam06733 502025001756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001757 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025001758 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001759 active site 502025001760 catalytic site [active] 502025001761 substrate binding site [chemical binding]; other site 502025001762 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025001763 active site 502025001764 catalytic residues [active] 502025001765 DNA binding site [nucleotide binding] 502025001766 Int/Topo IB signature motif; other site 502025001767 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 502025001768 active site 502025001769 dimer interface [polypeptide binding]; other site 502025001770 catalytic nucleophile [active] 502025001771 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001772 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001773 putative active site pocket [active] 502025001774 dimerization interface [polypeptide binding]; other site 502025001775 putative catalytic residue [active] 502025001776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001777 non-specific DNA binding site [nucleotide binding]; other site 502025001778 salt bridge; other site 502025001779 sequence-specific DNA binding site [nucleotide binding]; other site 502025001780 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001781 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001782 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001783 active site 502025001784 ATP binding site [chemical binding]; other site 502025001785 substrate binding site [chemical binding]; other site 502025001786 activation loop (A-loop); other site 502025001787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025001789 binding surface 502025001790 TPR motif; other site 502025001791 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025001792 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001793 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001794 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025001795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001796 ATP binding site [chemical binding]; other site 502025001797 putative Mg++ binding site [ion binding]; other site 502025001798 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025001799 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 502025001800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001801 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 502025001802 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 502025001803 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 502025001804 Family description; Region: UvrD_C_2; cl15862 502025001805 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 502025001806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001807 ATP binding site [chemical binding]; other site 502025001808 putative Mg++ binding site [ion binding]; other site 502025001809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001810 ATP-dependent helicase HepA; Validated; Region: PRK04914 502025001811 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 502025001812 Divergent AAA domain; Region: AAA_4; pfam04326 502025001813 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 502025001814 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025001815 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025001816 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025001817 Ca2+ binding site [ion binding]; other site 502025001818 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025001819 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 502025001820 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 502025001821 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025001822 active site 502025001823 metal binding site [ion binding]; metal-binding site 502025001824 short chain dehydrogenase; Provisional; Region: PRK06523 502025001825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001826 NAD(P) binding site [chemical binding]; other site 502025001827 active site 502025001828 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025001829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025001830 Helix-turn-helix domains; Region: HTH; cl00088 502025001831 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 502025001832 putative effector binding pocket; other site 502025001833 putative dimerization interface [polypeptide binding]; other site 502025001834 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001835 catalytic residues [active] 502025001836 catalytic nucleophile [active] 502025001837 Recombinase; Region: Recombinase; pfam07508 502025001838 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001839 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001840 DNA primase; Validated; Region: dnaG; PRK05667 502025001841 CHC2 zinc finger; Region: zf-CHC2; cl15369 502025001842 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025001843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001844 ATP binding site [chemical binding]; other site 502025001845 putative Mg++ binding site [ion binding]; other site 502025001846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001847 nucleotide binding region [chemical binding]; other site 502025001848 ATP-binding site [chemical binding]; other site 502025001849 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025001850 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001851 active site 502025001852 catalytic site [active] 502025001853 substrate binding site [chemical binding]; other site 502025001854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025001855 active site 502025001856 DNA binding site [nucleotide binding] 502025001857 Int/Topo IB signature motif; other site 502025001858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025001859 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 502025001860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001861 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025001862 FeS/SAM binding site; other site 502025001863 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025001864 O-methyltransferase; Region: Methyltransf_2; pfam00891 502025001865 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 502025001866 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001867 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001868 putative active site pocket [active] 502025001869 dimerization interface [polypeptide binding]; other site 502025001870 putative catalytic residue [active] 502025001871 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001872 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 502025001873 Condensation domain; Region: Condensation; pfam00668 502025001874 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025001875 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025001876 AMP-binding enzyme; Region: AMP-binding; cl15778 502025001877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025001879 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001880 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025001881 active site 502025001882 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025001883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001884 NAD(P) binding site [chemical binding]; other site 502025001885 active site 502025001886 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025001887 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025001888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001889 active site 502025001890 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025001891 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025001892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001893 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025001894 putative NADP binding site [chemical binding]; other site 502025001895 active site 502025001896 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025001897 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025001898 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001899 active site 502025001900 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025001901 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025001902 Enoylreductase; Region: PKS_ER; smart00829 502025001903 NAD(P) binding site [chemical binding]; other site 502025001904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001905 NAD(P) binding site [chemical binding]; other site 502025001906 active site 502025001907 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025001908 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001909 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025001910 active site 502025001911 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025001912 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 502025001913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025001914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025001915 hypothetical protein; Provisional; Region: PRK09956 502025001916 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025001917 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025001918 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025001919 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025001920 putative methyltransferase; Provisional; Region: PRK14968 502025001921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001922 S-adenosylmethionine binding site [chemical binding]; other site 502025001923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001924 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 502025001925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001926 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 502025001927 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 502025001928 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025001929 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 502025001930 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025001931 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025001932 hydrophobic ligand binding site; other site 502025001933 Cytochrome P450; Region: p450; pfam00067 502025001934 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025001935 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025001936 Cytochrome P450; Region: p450; pfam00067 502025001937 Cytochrome P450; Region: p450; pfam00067 502025001938 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025001939 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001940 catalytic residues [active] 502025001941 catalytic nucleophile [active] 502025001942 Recombinase; Region: Recombinase; pfam07508 502025001943 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001944 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001945 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025001946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001947 ATP binding site [chemical binding]; other site 502025001948 putative Mg++ binding site [ion binding]; other site 502025001949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001950 nucleotide binding region [chemical binding]; other site 502025001951 ATP-binding site [chemical binding]; other site 502025001952 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025001953 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001954 DEAD_2; Region: DEAD_2; pfam06733 502025001955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025001956 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025001957 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001958 active site 502025001959 catalytic site [active] 502025001960 substrate binding site [chemical binding]; other site 502025001961 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025001962 active site 502025001963 DNA binding site [nucleotide binding] 502025001964 Int/Topo IB signature motif; other site 502025001965 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025001966 Terminase-like family; Region: Terminase_6; pfam03237 502025001967 Phage-related protein [Function unknown]; Region: COG4695; cl01923 502025001968 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 502025001969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025001972 Phage capsid family; Region: Phage_capsid; pfam05065 502025001973 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 502025001974 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025001975 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025001976 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025001977 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 502025001978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 502025001979 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 502025001980 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025001981 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025001982 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 502025001983 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 502025001984 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001985 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001986 putative active site pocket [active] 502025001987 dimerization interface [polypeptide binding]; other site 502025001988 putative catalytic residue [active] 502025001989 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025001990 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001991 Bacterial SH3 domain; Region: SH3_3; cl02551 502025001992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025001993 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 502025001994 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025001995 protein-splicing catalytic site; other site 502025001996 thioester formation/cholesterol transfer; other site 502025001997 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025001998 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025001999 calcium binding site 2 [ion binding]; other site 502025002000 active site 502025002001 catalytic triad [active] 502025002002 calcium binding site 1 [ion binding]; other site 502025002003 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025002004 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025002005 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025002006 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002007 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002008 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002009 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002011 active site 502025002012 ATP binding site [chemical binding]; other site 502025002013 substrate binding site [chemical binding]; other site 502025002014 activation loop (A-loop); other site 502025002015 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025002016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025002017 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025002018 FG-GAP repeat; Region: FG-GAP; cl15299 502025002019 FG-GAP repeat; Region: FG-GAP; cl15299 502025002020 FG-GAP repeat; Region: FG-GAP; cl15299 502025002021 FG-GAP repeat; Region: FG-GAP; cl15299 502025002022 FG-GAP repeat; Region: FG-GAP; cl15299 502025002023 FG-GAP repeat; Region: FG-GAP; cl15299 502025002024 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002025 catalytic residues [active] 502025002026 catalytic nucleophile [active] 502025002027 Recombinase; Region: Recombinase; pfam07508 502025002028 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002029 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002030 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025002031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002032 ATP binding site [chemical binding]; other site 502025002033 putative Mg++ binding site [ion binding]; other site 502025002034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002035 nucleotide binding region [chemical binding]; other site 502025002036 ATP-binding site [chemical binding]; other site 502025002037 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 502025002038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002039 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025002040 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002041 active site 502025002042 catalytic site [active] 502025002043 substrate binding site [chemical binding]; other site 502025002044 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025002045 metal binding site [ion binding]; metal-binding site 502025002046 N-acetyltransferase; Region: Acetyltransf_2; cl00949 502025002047 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025002048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 502025002049 active site 502025002050 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025002051 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002052 putative active site pocket [active] 502025002053 dimerization interface [polypeptide binding]; other site 502025002054 putative catalytic residue [active] 502025002055 Bacterial SH3 domain; Region: SH3_3; cl02551 502025002056 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002059 active site 502025002060 ATP binding site [chemical binding]; other site 502025002061 substrate binding site [chemical binding]; other site 502025002062 activation loop (A-loop); other site 502025002063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002065 Walker A/P-loop; other site 502025002066 ATP binding site [chemical binding]; other site 502025002067 Q-loop/lid; other site 502025002068 ABC transporter signature motif; other site 502025002069 Walker B; other site 502025002070 H-loop/switch region; other site 502025002071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002072 binding surface 502025002073 TPR motif; other site 502025002074 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002075 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002076 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002077 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025002078 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025002079 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 502025002080 putative active site [active] 502025002081 putative NTP binding site [chemical binding]; other site 502025002082 putative nucleic acid binding site [nucleotide binding]; other site 502025002083 Helix-turn-helix domains; Region: HTH; cl00088 502025002084 Integrase core domain; Region: rve; cl01316 502025002085 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002087 Walker A motif; other site 502025002088 ATP binding site [chemical binding]; other site 502025002089 Walker B motif; other site 502025002090 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 502025002091 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 502025002092 Restriction endonuclease; Region: Mrr_cat; cl00516 502025002093 Predicted ATPase [General function prediction only]; Region: COG5293 502025002094 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 502025002095 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002096 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002097 catalytic residues [active] 502025002098 catalytic nucleophile [active] 502025002099 Recombinase; Region: Recombinase; pfam07508 502025002100 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002101 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002102 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025002103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002104 ATP binding site [chemical binding]; other site 502025002105 putative Mg++ binding site [ion binding]; other site 502025002106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002107 nucleotide binding region [chemical binding]; other site 502025002108 ATP-binding site [chemical binding]; other site 502025002109 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 502025002110 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025002111 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002112 active site 502025002113 catalytic site [active] 502025002114 substrate binding site [chemical binding]; other site 502025002115 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025002116 active site 502025002117 catalytic residues [active] 502025002118 DNA binding site [nucleotide binding] 502025002119 Int/Topo IB signature motif; other site 502025002120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002121 S-adenosylmethionine binding site [chemical binding]; other site 502025002122 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002123 putative active site pocket [active] 502025002124 dimerization interface [polypeptide binding]; other site 502025002125 putative catalytic residue [active] 502025002126 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002127 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025002128 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002129 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002130 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002133 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002134 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025002135 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002136 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002137 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002138 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002139 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002140 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002141 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002142 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002143 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002144 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002147 active site 502025002148 ATP binding site [chemical binding]; other site 502025002149 substrate binding site [chemical binding]; other site 502025002150 activation loop (A-loop); other site 502025002151 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002153 TPR motif; other site 502025002154 TPR repeat; Region: TPR_11; pfam13414 502025002155 binding surface 502025002156 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002157 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 502025002158 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002159 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025002160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002161 Tektin family; Region: Tektin; pfam03148 502025002162 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002163 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002164 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002165 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002166 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 502025002167 Integrase core domain; Region: rve; cl01316 502025002168 Integrase core domain; Region: rve_3; cl15866 502025002169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002170 active site 502025002171 ATP binding site [chemical binding]; other site 502025002172 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002173 substrate binding site [chemical binding]; other site 502025002174 activation loop (A-loop); other site 502025002175 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002176 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025002177 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025002178 N-terminal plug; other site 502025002179 ligand-binding site [chemical binding]; other site 502025002180 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025002181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025002182 Helix-turn-helix domains; Region: HTH; cl00088 502025002183 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025002184 substrate binding pocket [chemical binding]; other site 502025002185 dimerization interface [polypeptide binding]; other site 502025002186 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002187 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025002188 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002189 putative active site pocket [active] 502025002190 dimerization interface [polypeptide binding]; other site 502025002191 putative catalytic residue [active] 502025002192 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025002193 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025002194 Terminase-like family; Region: Terminase_6; pfam03237 502025002195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025002196 active site 502025002197 DNA binding site [nucleotide binding] 502025002198 Int/Topo IB signature motif; other site 502025002199 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002200 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002201 active site 502025002202 catalytic site [active] 502025002203 substrate binding site [chemical binding]; other site 502025002204 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025002205 DNA primase domain-containing protein; Region: PHA02415 502025002206 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025002207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002208 ATP binding site [chemical binding]; other site 502025002209 putative Mg++ binding site [ion binding]; other site 502025002210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002211 nucleotide binding region [chemical binding]; other site 502025002212 ATP-binding site [chemical binding]; other site 502025002213 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002214 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002215 catalytic residues [active] 502025002216 catalytic nucleophile [active] 502025002217 Recombinase; Region: Recombinase; pfam07508 502025002218 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002219 TIR domain; Region: TIR_2; cl15770 502025002220 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 502025002221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002222 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025002223 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 502025002224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002225 Walker A motif; other site 502025002226 ATP binding site [chemical binding]; other site 502025002227 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002228 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025002229 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002230 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002231 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002232 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002233 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 502025002234 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002235 Tektin family; Region: Tektin; pfam03148 502025002236 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002237 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002238 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002239 Tektin family; Region: Tektin; pfam03148 502025002240 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002241 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002243 Tektin family; Region: Tektin; pfam03148 502025002244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002245 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002247 Walker A motif; other site 502025002248 ATP binding site [chemical binding]; other site 502025002249 Walker B motif; other site 502025002250 Integrase core domain; Region: rve; cl01316 502025002251 FG-GAP repeat; Region: FG-GAP; cl15299 502025002252 FG-GAP repeat; Region: FG-GAP; cl15299 502025002253 FG-GAP repeat; Region: FG-GAP; cl15299 502025002254 FG-GAP repeat; Region: FG-GAP; cl15299 502025002255 FG-GAP repeat; Region: FG-GAP; cl15299 502025002256 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002257 ligand binding site [chemical binding]; other site 502025002258 flexible hinge region; other site 502025002259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002260 S-adenosylmethionine binding site [chemical binding]; other site 502025002261 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002266 Integrase core domain; Region: rve; cl01316 502025002267 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002269 Walker A motif; other site 502025002270 ATP binding site [chemical binding]; other site 502025002271 Walker B motif; other site 502025002272 Bacterial Ig-like domain; Region: Big_5; cl01012 502025002273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002274 Walker A motif; other site 502025002275 ATP binding site [chemical binding]; other site 502025002276 Walker B motif; other site 502025002277 Integrase core domain; Region: rve; cl01316 502025002278 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002279 peptide synthase; Provisional; Region: PRK12467 502025002280 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002281 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002282 peptide synthase; Provisional; Region: PRK12467 502025002283 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002284 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002285 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002286 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002287 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002289 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025002291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002292 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002293 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002294 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025002295 active site 502025002296 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025002297 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 502025002298 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 502025002299 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 502025002300 active site 502025002301 catalytic residues [active] 502025002302 metal binding site [ion binding]; metal-binding site 502025002303 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 502025002304 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 502025002305 homodimer interface [polypeptide binding]; other site 502025002306 substrate-cofactor binding pocket; other site 502025002307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025002308 catalytic residue [active] 502025002309 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 502025002310 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 502025002311 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002312 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002313 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002315 non-specific DNA binding site [nucleotide binding]; other site 502025002316 salt bridge; other site 502025002317 sequence-specific DNA binding site [nucleotide binding]; other site 502025002318 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002319 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002320 active site 502025002321 ATP binding site [chemical binding]; other site 502025002322 substrate binding site [chemical binding]; other site 502025002323 activation loop (A-loop); other site 502025002324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002325 TPR repeat; Region: TPR_11; pfam13414 502025002326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002327 binding surface 502025002328 TPR motif; other site 502025002329 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002330 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002332 Walker A motif; other site 502025002333 ATP binding site [chemical binding]; other site 502025002334 Walker B motif; other site 502025002335 Integrase core domain; Region: rve; cl01316 502025002336 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002338 active site 502025002339 ATP binding site [chemical binding]; other site 502025002340 substrate binding site [chemical binding]; other site 502025002341 activation loop (A-loop); other site 502025002342 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002343 active site 502025002344 ATP binding site [chemical binding]; other site 502025002345 substrate binding site [chemical binding]; other site 502025002346 activation loop (A-loop); other site 502025002347 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002349 TPR motif; other site 502025002350 binding surface 502025002351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002352 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002355 binding surface 502025002356 TPR motif; other site 502025002357 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002358 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002359 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002360 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002361 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002362 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002363 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002364 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002365 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002366 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002367 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002368 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002369 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025002370 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002371 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002372 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002373 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002376 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002381 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002382 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002383 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002386 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025002387 Walker A motif; other site 502025002388 ATP binding site [chemical binding]; other site 502025002389 Walker B motif; other site 502025002390 arginine finger; other site 502025002391 Helix-turn-helix domains; Region: HTH; cl00088 502025002392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025002393 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 502025002394 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025002395 Sel1 repeat; Region: Sel1; cl02723 502025002396 Sel1 repeat; Region: Sel1; cl02723 502025002397 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025002398 Sel1 repeat; Region: Sel1; cl02723 502025002399 Sel1 repeat; Region: Sel1; cl02723 502025002400 Sel1 repeat; Region: Sel1; cl02723 502025002401 Sel1 repeat; Region: Sel1; cl02723 502025002402 Sel1 repeat; Region: Sel1; cl02723 502025002403 Sel1 repeat; Region: Sel1; cl02723 502025002404 Sel1 repeat; Region: Sel1; cl02723 502025002405 Sel1 repeat; Region: Sel1; cl02723 502025002406 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 502025002407 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025002408 putative active site [active] 502025002409 putative NTP binding site [chemical binding]; other site 502025002410 putative nucleic acid binding site [nucleotide binding]; other site 502025002411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002412 Walker A motif; other site 502025002413 ATP binding site [chemical binding]; other site 502025002414 Walker B motif; other site 502025002415 Integrase core domain; Region: rve; cl01316 502025002416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002417 Walker A motif; other site 502025002418 ATP binding site [chemical binding]; other site 502025002419 Walker B motif; other site 502025002420 Helix-turn-helix domains; Region: HTH; cl00088 502025002421 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 502025002422 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002425 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025002427 Helix-turn-helix domains; Region: HTH; cl00088 502025002428 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002429 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002430 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 502025002431 CHAT domain; Region: CHAT; pfam12770 502025002432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002434 active site 502025002435 ATP binding site [chemical binding]; other site 502025002436 substrate binding site [chemical binding]; other site 502025002437 activation loop (A-loop); other site 502025002438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002440 binding surface 502025002441 TPR motif; other site 502025002442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002443 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002445 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025002446 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025002447 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002448 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025002450 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 502025002451 substrate binding site [chemical binding]; other site 502025002452 oxyanion hole (OAH) forming residues; other site 502025002453 trimer interface [polypeptide binding]; other site 502025002454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002455 S-adenosylmethionine binding site [chemical binding]; other site 502025002456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025002457 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002458 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002459 active site 502025002460 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002461 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002462 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 502025002463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002464 S-adenosylmethionine binding site [chemical binding]; other site 502025002465 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002468 active site 502025002469 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002470 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002471 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002472 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002473 putative NADP binding site [chemical binding]; other site 502025002474 active site 502025002475 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002476 FkbH-like domain; Region: FkbH; TIGR01686 502025002477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025002478 active site 502025002479 motif I; other site 502025002480 motif II; other site 502025002481 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025002482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025002483 active site 502025002484 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002485 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 502025002486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002487 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025002488 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002489 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002490 active site 502025002491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002492 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002493 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 502025002494 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 502025002495 dimer interface [polypeptide binding]; other site 502025002496 active site 502025002497 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002498 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025002499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025002500 substrate binding site [chemical binding]; other site 502025002501 oxyanion hole (OAH) forming residues; other site 502025002502 trimer interface [polypeptide binding]; other site 502025002503 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 502025002504 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002505 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 502025002506 active site 502025002507 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002508 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025002509 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002510 active site 502025002511 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002512 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002513 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002514 putative NADP binding site [chemical binding]; other site 502025002515 active site 502025002516 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002517 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002518 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002519 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025002521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025002522 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025002523 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025002524 active site 502025002525 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002526 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002527 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002528 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025002529 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002530 active site 502025002531 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025002532 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002534 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025002535 Enoylreductase; Region: PKS_ER; smart00829 502025002536 NAD(P) binding site [chemical binding]; other site 502025002537 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002538 putative NADP binding site [chemical binding]; other site 502025002539 active site 502025002540 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002541 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 502025002542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025002545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002546 non-specific DNA binding site [nucleotide binding]; other site 502025002547 salt bridge; other site 502025002548 sequence-specific DNA binding site [nucleotide binding]; other site 502025002549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002551 active site 502025002552 ATP binding site [chemical binding]; other site 502025002553 substrate binding site [chemical binding]; other site 502025002554 activation loop (A-loop); other site 502025002555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002556 TPR repeat; Region: TPR_11; pfam13414 502025002557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002558 binding surface 502025002559 TPR motif; other site 502025002560 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002561 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025002562 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002563 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 502025002564 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 502025002565 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002566 Restriction endonuclease; Region: Mrr_cat; cl00516 502025002567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002568 active site 502025002569 ATP binding site [chemical binding]; other site 502025002570 substrate binding site [chemical binding]; other site 502025002571 activation loop (A-loop); other site 502025002572 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002573 active site 502025002574 ATP binding site [chemical binding]; other site 502025002575 substrate binding site [chemical binding]; other site 502025002576 activation loop (A-loop); other site 502025002577 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 502025002578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025002579 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025002580 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025002581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002582 ATP binding site [chemical binding]; other site 502025002583 putative Mg++ binding site [ion binding]; other site 502025002584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002585 nucleotide binding region [chemical binding]; other site 502025002586 ATP-binding site [chemical binding]; other site 502025002587 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002588 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002590 active site 502025002591 ATP binding site [chemical binding]; other site 502025002592 substrate binding site [chemical binding]; other site 502025002593 activation loop (A-loop); other site 502025002594 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002595 catalytic residues [active] 502025002596 catalytic nucleophile [active] 502025002597 Recombinase; Region: Recombinase; pfam07508 502025002598 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002599 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002600 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025002601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002602 ATP binding site [chemical binding]; other site 502025002603 putative Mg++ binding site [ion binding]; other site 502025002604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002605 nucleotide binding region [chemical binding]; other site 502025002606 ATP-binding site [chemical binding]; other site 502025002607 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002609 non-specific DNA binding site [nucleotide binding]; other site 502025002610 salt bridge; other site 502025002611 sequence-specific DNA binding site [nucleotide binding]; other site 502025002612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002614 active site 502025002615 ATP binding site [chemical binding]; other site 502025002616 substrate binding site [chemical binding]; other site 502025002617 activation loop (A-loop); other site 502025002618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002619 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025002620 FG-GAP repeat; Region: FG-GAP; cl15299 502025002621 FG-GAP repeat; Region: FG-GAP; cl15299 502025002622 FG-GAP repeat; Region: FG-GAP; cl15299 502025002623 FG-GAP repeat; Region: FG-GAP; cl15299 502025002624 FG-GAP repeat; Region: FG-GAP; cl15299 502025002625 FG-GAP repeat; Region: FG-GAP; cl15299 502025002626 FG-GAP repeat; Region: FG-GAP; cl15299 502025002627 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 502025002628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025002629 PglZ domain; Region: PglZ; pfam08665 502025002630 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025002631 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025002632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002633 ATP binding site [chemical binding]; other site 502025002634 putative Mg++ binding site [ion binding]; other site 502025002635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002636 nucleotide binding region [chemical binding]; other site 502025002637 ATP-binding site [chemical binding]; other site 502025002638 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025002639 catalytic site [active] 502025002640 putative active site [active] 502025002641 putative substrate binding site [chemical binding]; other site 502025002642 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025002643 PhoD-like phosphatase; Region: PhoD; pfam09423 502025002644 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025002645 putative active site [active] 502025002646 putative metal binding site [ion binding]; other site 502025002647 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025002648 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 502025002649 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 502025002650 active site 2 [active] 502025002651 active site 1 [active] 502025002652 MgtC family; Region: MgtC; pfam02308 502025002653 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025002654 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025002655 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025002656 Cytochrome c; Region: Cytochrom_C; cl11414 502025002657 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 502025002658 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025002659 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002660 ligand binding site [chemical binding]; other site 502025002661 flexible hinge region; other site 502025002662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002663 ligand binding site [chemical binding]; other site 502025002664 flexible hinge region; other site 502025002665 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 502025002666 substrate binding pocket [chemical binding]; other site 502025002667 substrate-Mg2+ binding site; other site 502025002668 aspartate-rich region 1; other site 502025002669 active site lid residues [active] 502025002670 aspartate-rich region 2; other site 502025002671 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025002672 substrate binding pocket [chemical binding]; other site 502025002673 substrate-Mg2+ binding site; other site 502025002674 aspartate-rich region 1; other site 502025002675 aspartate-rich region 2; other site 502025002676 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025002679 DNA binding residues [nucleotide binding] 502025002680 Protein kinase; unclassified specificity; Region: STYKc; smart00221 502025002681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002682 active site 502025002683 ATP binding site [chemical binding]; other site 502025002684 substrate binding site [chemical binding]; other site 502025002685 activation loop (A-loop); other site 502025002686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002687 CHAT domain; Region: CHAT; pfam12770 502025002688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002689 binding surface 502025002690 TPR motif; other site 502025002691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002694 binding surface 502025002695 TPR motif; other site 502025002696 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002698 binding surface 502025002699 TPR motif; other site 502025002700 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002703 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025002704 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 502025002705 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 502025002706 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025002707 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 502025002708 putative hydrophobic ligand binding site [chemical binding]; other site 502025002709 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025002712 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025002713 Helix-turn-helix domains; Region: HTH; cl00088 502025002714 Predicted transcriptional regulator [Transcription]; Region: COG2345 502025002715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 502025002716 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025002717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002718 active site 502025002719 ATP binding site [chemical binding]; other site 502025002720 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025002721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002722 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002723 active site 502025002724 ATP binding site [chemical binding]; other site 502025002725 substrate binding site [chemical binding]; other site 502025002726 activation loop (A-loop); other site 502025002727 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002729 structural tetrad; other site 502025002730 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002731 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025002732 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 502025002733 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025002734 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 502025002735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002736 FeS/SAM binding site; other site 502025002737 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 502025002738 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025002739 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025002740 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025002741 nudix motif; other site 502025002742 hypothetical protein; Provisional; Region: PRK07588 502025002743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002744 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025002745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025002746 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025002747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025002748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002749 Walker A/P-loop; other site 502025002750 ATP binding site [chemical binding]; other site 502025002751 Q-loop/lid; other site 502025002752 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 502025002753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025002754 Walker A/P-loop; other site 502025002755 ATP binding site [chemical binding]; other site 502025002756 Q-loop/lid; other site 502025002757 ABC transporter signature motif; other site 502025002758 Walker B; other site 502025002759 D-loop; other site 502025002760 H-loop/switch region; other site 502025002761 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 502025002762 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025002763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025002764 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025002765 glycosyltransferase, MGT family; Region: MGT; TIGR01426 502025002766 active site 502025002767 TDP-binding site; other site 502025002768 acceptor substrate-binding pocket; other site 502025002769 homodimer interface [polypeptide binding]; other site 502025002770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025002771 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025002772 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 502025002773 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025002774 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025002775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002776 catalytic residue [active] 502025002777 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 502025002778 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002779 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 502025002780 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 502025002781 catalytic triad [active] 502025002782 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025002783 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 502025002784 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 502025002785 C-terminal domain interface [polypeptide binding]; other site 502025002786 GSH binding site (G-site) [chemical binding]; other site 502025002787 dimer interface [polypeptide binding]; other site 502025002788 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025002789 N-terminal domain interface [polypeptide binding]; other site 502025002790 dimer interface [polypeptide binding]; other site 502025002791 substrate binding pocket (H-site) [chemical binding]; other site 502025002792 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025002793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002794 FeS/SAM binding site; other site 502025002795 SCP-2 sterol transfer family; Region: SCP2; cl01225 502025002796 JmjC domain, hydroxylase; Region: JmjC; cl15814 502025002797 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025002798 B12 binding site [chemical binding]; other site 502025002799 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 502025002800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002801 FeS/SAM binding site; other site 502025002802 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025002803 Cytochrome P450; Region: p450; pfam00067 502025002804 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 502025002805 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 502025002806 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 502025002807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002809 catalytic residue [active] 502025002810 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 502025002811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002812 S-adenosylmethionine binding site [chemical binding]; other site 502025002813 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002814 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025002815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002816 catalytic residue [active] 502025002817 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 502025002818 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025002819 RHS Repeat; Region: RHS_repeat; cl11982 502025002820 RHS Repeat; Region: RHS_repeat; cl11982 502025002821 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025002822 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025002823 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025002824 protein-splicing catalytic site; other site 502025002825 thioester formation/cholesterol transfer; other site 502025002826 Pretoxin HINT domain; Region: PT-HINT; pfam07591 502025002827 SET domain; Region: SET; cl02566 502025002828 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 502025002829 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002830 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002831 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 502025002832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002834 catalytic residue [active] 502025002835 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025002836 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 502025002837 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025002838 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 502025002839 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 502025002840 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 502025002841 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 502025002842 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 502025002843 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025002844 CHAT domain; Region: CHAT; pfam12770 502025002845 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025002848 DNA binding residues [nucleotide binding] 502025002849 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002850 active site 502025002851 ATP binding site [chemical binding]; other site 502025002852 substrate binding site [chemical binding]; other site 502025002853 activation loop (A-loop); other site 502025002854 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 502025002855 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 502025002856 Restriction endonuclease; Region: Mrr_cat; cl00516 502025002857 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025002858 putative active site [active] 502025002859 putative metal binding site [ion binding]; other site 502025002860 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025002861 NB-ARC domain; Region: NB-ARC; pfam00931 502025002862 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 502025002863 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002864 structural tetrad; other site 502025002865 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002866 structural tetrad; other site 502025002867 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 502025002868 Protein of unknown function (DUF524); Region: DUF524; pfam04411 502025002869 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 502025002870 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 502025002871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025002872 Helix-turn-helix domains; Region: HTH; cl00088 502025002873 WHG domain; Region: WHG; pfam13305 502025002874 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002875 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025002876 FG-GAP repeat; Region: FG-GAP; cl15299 502025002877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025002878 classical (c) SDRs; Region: SDR_c; cd05233 502025002879 NAD(P) binding site [chemical binding]; other site 502025002880 active site 502025002881 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002882 TPR repeat; Region: TPR_11; pfam13414 502025002883 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002885 catalytic residue [active] 502025002886 hypothetical protein; Provisional; Region: PRK06834 502025002887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002888 NB-ARC domain; Region: NB-ARC; pfam00931 502025002889 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002890 structural tetrad; other site 502025002891 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025002892 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002893 structural tetrad; other site 502025002894 transcriptional regulator; Provisional; Region: PRK10632 502025002895 Helix-turn-helix domains; Region: HTH; cl00088 502025002896 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025002897 putative effector binding pocket; other site 502025002898 dimerization interface [polypeptide binding]; other site 502025002899 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 502025002900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025002901 active site 502025002902 metal binding site [ion binding]; metal-binding site 502025002903 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 502025002904 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 502025002905 pyranose oxidase; Region: pyranose_ox; TIGR02462 502025002906 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025002907 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 502025002908 putative sugar binding site [chemical binding]; other site 502025002909 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 502025002910 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 502025002911 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025002912 active site 502025002913 TDP-binding site; other site 502025002914 acceptor substrate-binding pocket; other site 502025002915 homodimer interface [polypeptide binding]; other site 502025002916 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 502025002917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025002918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025002919 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025002920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025002921 active site 502025002922 catalytic tetrad [active] 502025002923 Cupin domain; Region: Cupin_2; cl09118 502025002924 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025002925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025002926 Response regulator receiver domain; Region: Response_reg; pfam00072 502025002927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025002928 active site 502025002929 phosphorylation site [posttranslational modification] 502025002930 intermolecular recognition site; other site 502025002931 dimerization interface [polypeptide binding]; other site 502025002932 NMT1/THI5 like; Region: NMT1; pfam09084 502025002933 NMT1-like family; Region: NMT1_2; cl15260 502025002934 GAF domain; Region: GAF_2; pfam13185 502025002935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025002936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025002937 dimerization interface [polypeptide binding]; other site 502025002938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025002939 dimer interface [polypeptide binding]; other site 502025002940 phosphorylation site [posttranslational modification] 502025002941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025002942 ATP binding site [chemical binding]; other site 502025002943 Mg2+ binding site [ion binding]; other site 502025002944 G-X-G motif; other site 502025002945 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025002946 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 502025002947 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025002948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025002949 catalytic loop [active] 502025002950 iron binding site [ion binding]; other site 502025002951 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025002952 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025002953 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025002954 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025002955 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025002956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025002957 putative substrate translocation pore; other site 502025002958 MbtH-like protein; Region: MbtH; cl01279 502025002959 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 502025002960 Glutamine amidotransferase class-I; Region: GATase; pfam00117 502025002961 glutamine binding [chemical binding]; other site 502025002962 catalytic triad [active] 502025002963 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 502025002964 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 502025002965 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025002966 acyl-CoA synthetase; Validated; Region: PRK05850 502025002967 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002968 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002969 peptide synthase; Provisional; Region: PRK12316 502025002970 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002971 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002972 peptide synthase; Validated; Region: PRK05691 502025002973 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002974 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002975 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002976 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002977 peptide synthase; Provisional; Region: PRK12467 502025002978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002979 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002980 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002981 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002982 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002983 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002984 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002985 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002986 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025002987 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002988 AMP-binding enzyme; Region: AMP-binding; cl15778 502025002989 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025002990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002991 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 502025002992 NAD(P) binding site [chemical binding]; other site 502025002993 Trm112p-like protein; Region: Trm112p; cl01066 502025002994 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 502025002995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025002996 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 502025002997 Chorismate mutase type II; Region: CM_2; cl00693 502025002998 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025002999 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025003000 putative ligand binding site [chemical binding]; other site 502025003001 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 502025003002 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025003003 FG-GAP repeat; Region: FG-GAP; cl15299 502025003004 FG-GAP repeat; Region: FG-GAP; cl15299 502025003005 FG-GAP repeat; Region: FG-GAP; cl15299 502025003006 FG-GAP repeat; Region: FG-GAP; cl15299 502025003007 FG-GAP repeat; Region: FG-GAP; cl15299 502025003008 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025003009 putative active site [active] 502025003010 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025003012 regulatory ATPase RavA; Provisional; Region: PRK13531 502025003013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003014 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 502025003015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025003016 metal ion-dependent adhesion site (MIDAS); other site 502025003017 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 502025003018 putative hydrophobic ligand binding site [chemical binding]; other site 502025003019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025003020 dimerization interface [polypeptide binding]; other site 502025003021 putative DNA binding site [nucleotide binding]; other site 502025003022 putative Zn2+ binding site [ion binding]; other site 502025003023 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025003024 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025003025 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003026 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025003027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003028 Helix-turn-helix domains; Region: HTH; cl00088 502025003029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025003030 S-adenosylmethionine binding site [chemical binding]; other site 502025003031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025003032 Coenzyme A binding pocket [chemical binding]; other site 502025003033 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025003034 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025003035 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 502025003036 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003038 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003039 active site 502025003040 ATP binding site [chemical binding]; other site 502025003041 substrate binding site [chemical binding]; other site 502025003042 activation loop (A-loop); other site 502025003043 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 502025003044 Predicted ATPase [General function prediction only]; Region: COG3899 502025003045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003047 active site 502025003048 ATP binding site [chemical binding]; other site 502025003049 substrate binding site [chemical binding]; other site 502025003050 activation loop (A-loop); other site 502025003051 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025003052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025003054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003057 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025003058 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003059 phosphopeptide binding site; other site 502025003060 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025003061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003062 Walker A motif; other site 502025003063 ATP binding site [chemical binding]; other site 502025003064 Walker B motif; other site 502025003065 arginine finger; other site 502025003066 Helix-turn-helix domains; Region: HTH; cl00088 502025003067 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 502025003068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025003069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003071 active site 502025003072 ATP binding site [chemical binding]; other site 502025003073 substrate binding site [chemical binding]; other site 502025003074 activation loop (A-loop); other site 502025003075 Predicted ATPase [General function prediction only]; Region: COG3899 502025003076 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025003077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025003078 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 502025003079 CheB methylesterase; Region: CheB_methylest; pfam01339 502025003080 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025003081 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025003083 HOOK protein; Region: HOOK; pfam05622 502025003084 PAS domain; Region: PAS_10; pfam13596 502025003085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025003086 PAS fold; Region: PAS_3; pfam08447 502025003087 putative active site [active] 502025003088 heme pocket [chemical binding]; other site 502025003089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025003090 PAS domain; Region: PAS_9; pfam13426 502025003091 putative active site [active] 502025003092 heme pocket [chemical binding]; other site 502025003093 PAS fold; Region: PAS_4; pfam08448 502025003094 sensory histidine kinase AtoS; Provisional; Region: PRK11360 502025003095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025003096 dimer interface [polypeptide binding]; other site 502025003097 phosphorylation site [posttranslational modification] 502025003098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025003099 ATP binding site [chemical binding]; other site 502025003100 Mg2+ binding site [ion binding]; other site 502025003101 G-X-G motif; other site 502025003102 Response regulator receiver domain; Region: Response_reg; pfam00072 502025003103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025003104 active site 502025003105 phosphorylation site [posttranslational modification] 502025003106 intermolecular recognition site; other site 502025003107 dimerization interface [polypeptide binding]; other site 502025003108 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025003109 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025003110 putative C-terminal domain interface [polypeptide binding]; other site 502025003111 putative GSH binding site (G-site) [chemical binding]; other site 502025003112 putative dimer interface [polypeptide binding]; other site 502025003113 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 502025003114 dimer interface [polypeptide binding]; other site 502025003115 N-terminal domain interface [polypeptide binding]; other site 502025003116 putative substrate binding pocket (H-site) [chemical binding]; other site 502025003117 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 502025003118 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 502025003119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025003120 FeS/SAM binding site; other site 502025003121 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025003122 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025003123 Cupin domain; Region: Cupin_2; cl09118 502025003124 Cupin domain; Region: Cupin_2; cl09118 502025003125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003127 active site 502025003128 ATP binding site [chemical binding]; other site 502025003129 substrate binding site [chemical binding]; other site 502025003130 activation loop (A-loop); other site 502025003131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003132 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003133 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003134 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003135 structural tetrad; other site 502025003136 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003137 structural tetrad; other site 502025003138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003140 active site 502025003141 ATP binding site [chemical binding]; other site 502025003142 substrate binding site [chemical binding]; other site 502025003143 activation loop (A-loop); other site 502025003144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003145 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003146 structural tetrad; other site 502025003147 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003148 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003149 structural tetrad; other site 502025003150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003153 active site 502025003154 ATP binding site [chemical binding]; other site 502025003155 substrate binding site [chemical binding]; other site 502025003156 activation loop (A-loop); other site 502025003157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003158 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 502025003159 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025003160 ligand binding site [chemical binding]; other site 502025003161 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025003162 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 502025003163 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025003164 Ligand Binding Site [chemical binding]; other site 502025003165 Molecular Tunnel; other site 502025003166 short chain dehydrogenase; Provisional; Region: PRK06914 502025003167 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 502025003168 NADP binding site [chemical binding]; other site 502025003169 active site 502025003170 steroid binding site; other site 502025003171 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025003172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025003173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025003174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003176 active site 502025003177 ATP binding site [chemical binding]; other site 502025003178 substrate binding site [chemical binding]; other site 502025003179 activation loop (A-loop); other site 502025003180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003181 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003182 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003183 structural tetrad; other site 502025003184 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003185 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003186 structural tetrad; other site 502025003187 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003188 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003189 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003190 active site 502025003191 ATP binding site [chemical binding]; other site 502025003192 substrate binding site [chemical binding]; other site 502025003193 activation loop (A-loop); other site 502025003194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003195 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003196 structural tetrad; other site 502025003197 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003198 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003199 structural tetrad; other site 502025003200 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 502025003201 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003202 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003203 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003204 active site 502025003205 ATP binding site [chemical binding]; other site 502025003206 substrate binding site [chemical binding]; other site 502025003207 activation loop (A-loop); other site 502025003208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003209 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003210 structural tetrad; other site 502025003211 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003212 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003213 structural tetrad; other site 502025003214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003215 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025003216 oxyanion hole [active] 502025003217 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025003218 catalytic triad [active] 502025003219 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 502025003220 dinuclear metal binding motif [ion binding]; other site 502025003221 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025003222 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025003223 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 502025003224 Helix-turn-helix domains; Region: HTH; cl00088 502025003225 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025003226 homotrimer interaction site [polypeptide binding]; other site 502025003227 putative active site [active] 502025003228 Protein of unknown function (DUF808); Region: DUF808; cl01002 502025003229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025003230 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 502025003231 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 502025003232 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 502025003233 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025003234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025003235 active site 502025003236 catalytic tetrad [active] 502025003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003238 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025003239 NAD(P) binding site [chemical binding]; other site 502025003240 active site 502025003241 YhhN-like protein; Region: YhhN; cl01505 502025003242 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 502025003243 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025003244 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025003245 Cupin domain; Region: Cupin_2; cl09118 502025003246 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003247 Giardia variant-specific surface protein; Region: VSP; pfam03302 502025003248 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003249 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003250 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003251 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025003252 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025003253 ligand binding site [chemical binding]; other site 502025003254 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025003255 ligand binding site [chemical binding]; other site 502025003256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003257 phosphopeptide binding site; other site 502025003258 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025003259 metal binding site [ion binding]; metal-binding site 502025003260 active site 502025003261 I-site; other site 502025003262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003263 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025003264 Walker A motif; other site 502025003265 ATP binding site [chemical binding]; other site 502025003266 Walker B motif; other site 502025003267 arginine finger; other site 502025003268 Helix-turn-helix domains; Region: HTH; cl00088 502025003269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003270 active site 502025003271 ATP binding site [chemical binding]; other site 502025003272 substrate binding site [chemical binding]; other site 502025003273 activation loop (A-loop); other site 502025003274 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025003275 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025003276 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025003277 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025003278 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025003279 DTW domain; Region: DTW; cl01221 502025003280 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025003281 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025003282 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025003283 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025003284 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025003285 catalytic residues [active] 502025003286 EamA-like transporter family; Region: EamA; cl01037 502025003287 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 502025003288 EamA-like transporter family; Region: EamA; cl01037 502025003289 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003290 structural tetrad; other site 502025003291 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025003292 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 502025003293 chitin/cellulose binding site [chemical binding]; other site 502025003294 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 502025003295 Glyco_18 domain; Region: Glyco_18; smart00636 502025003296 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 502025003297 active site 502025003298 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 502025003299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 502025003300 DNA-binding site [nucleotide binding]; DNA binding site 502025003301 UTRA domain; Region: UTRA; cl01230 502025003302 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 502025003303 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 502025003304 putative active site [active] 502025003305 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 502025003306 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 502025003307 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 502025003308 active site 502025003309 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 502025003310 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 502025003311 HPr interaction site; other site 502025003312 glycerol kinase (GK) interaction site [polypeptide binding]; other site 502025003313 active site 502025003314 phosphorylation site [posttranslational modification] 502025003315 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 502025003316 dimerization domain swap beta strand [polypeptide binding]; other site 502025003317 regulatory protein interface [polypeptide binding]; other site 502025003318 active site 502025003319 regulatory phosphorylation site [posttranslational modification]; other site 502025003320 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 502025003321 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 502025003322 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 502025003323 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 502025003324 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 502025003325 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 502025003326 active site 502025003327 dimer interface [polypeptide binding]; other site 502025003328 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 502025003329 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 502025003330 dimer interface [polypeptide binding]; other site 502025003331 active site 502025003332 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 502025003333 dimer interface [polypeptide binding]; other site 502025003334 active site 502025003335 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 502025003336 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 502025003337 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 502025003338 active site turn [active] 502025003339 phosphorylation site [posttranslational modification] 502025003340 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025003341 sugar binding site [chemical binding]; other site 502025003342 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 502025003343 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 502025003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025003345 dimer interface [polypeptide binding]; other site 502025003346 conserved gate region; other site 502025003347 putative PBP binding loops; other site 502025003348 ABC-ATPase subunit interface; other site 502025003349 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025003350 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 502025003351 Walker A/P-loop; other site 502025003352 ATP binding site [chemical binding]; other site 502025003353 Q-loop/lid; other site 502025003354 ABC transporter signature motif; other site 502025003355 Walker B; other site 502025003356 D-loop; other site 502025003357 H-loop/switch region; other site 502025003358 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025003359 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 502025003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025003361 dimer interface [polypeptide binding]; other site 502025003362 conserved gate region; other site 502025003363 putative PBP binding loops; other site 502025003364 ABC-ATPase subunit interface; other site 502025003365 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025003366 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 502025003367 Walker A/P-loop; other site 502025003368 ATP binding site [chemical binding]; other site 502025003369 Q-loop/lid; other site 502025003370 ABC transporter signature motif; other site 502025003371 Walker B; other site 502025003372 D-loop; other site 502025003373 H-loop/switch region; other site 502025003374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025003375 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 502025003376 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025003377 substrate binding site [chemical binding]; other site 502025003378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 502025003379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 502025003380 DNA binding site [nucleotide binding] 502025003381 domain linker motif; other site 502025003382 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 502025003383 dimerization interface [polypeptide binding]; other site 502025003384 ligand binding site [chemical binding]; other site 502025003385 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025003386 SpaB C-terminal domain; Region: SpaB_C; cl14828 502025003387 SpaB C-terminal domain; Region: SpaB_C; cl14828 502025003388 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025003389 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 502025003390 active site 502025003391 zinc binding site [ion binding]; other site 502025003392 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 502025003393 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025003394 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 502025003395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003396 Helix-turn-helix domains; Region: HTH; cl00088 502025003397 LysR family transcriptional regulator; Provisional; Region: PRK14997 502025003398 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003399 putative effector binding pocket; other site 502025003400 dimerization interface [polypeptide binding]; other site 502025003401 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 502025003402 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025003403 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025003404 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 502025003405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003407 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003408 active site 502025003409 ATP binding site [chemical binding]; other site 502025003410 substrate binding site [chemical binding]; other site 502025003411 activation loop (A-loop); other site 502025003412 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003413 TPR repeat; Region: TPR_11; pfam13414 502025003414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025003415 TPR motif; other site 502025003416 binding surface 502025003417 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003418 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025003420 TPR motif; other site 502025003421 binding surface 502025003422 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025003425 non-specific DNA binding site [nucleotide binding]; other site 502025003426 salt bridge; other site 502025003427 sequence-specific DNA binding site [nucleotide binding]; other site 502025003428 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003429 Protein kinase domain; Region: Pkinase; pfam00069 502025003430 active site 502025003431 ATP binding site [chemical binding]; other site 502025003432 substrate binding site [chemical binding]; other site 502025003433 activation loop (A-loop); other site 502025003434 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025003435 Family description; Region: VCBS; pfam13517 502025003436 Family description; Region: VCBS; pfam13517 502025003437 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025003438 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025003439 RHS Repeat; Region: RHS_repeat; cl11982 502025003440 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025003441 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025003442 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025003443 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 502025003444 FIST N domain; Region: FIST; cl10701 502025003445 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025003446 FIST C domain; Region: FIST_C; pfam10442 502025003447 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025003448 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 502025003449 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025003450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025003451 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 502025003452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003454 DNA binding residues [nucleotide binding] 502025003455 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003456 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 502025003457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025003458 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025003459 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003461 active site 502025003462 ATP binding site [chemical binding]; other site 502025003463 substrate binding site [chemical binding]; other site 502025003464 activation loop (A-loop); other site 502025003465 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025003466 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025003467 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025003468 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003469 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003470 active site 502025003471 ATP binding site [chemical binding]; other site 502025003472 substrate binding site [chemical binding]; other site 502025003473 activation loop (A-loop); other site 502025003474 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025003475 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003476 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003477 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003478 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003479 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003480 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003481 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003482 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025003483 FG-GAP repeat; Region: FG-GAP; cl15299 502025003484 FG-GAP repeat; Region: FG-GAP; cl15299 502025003485 FG-GAP repeat; Region: FG-GAP; cl15299 502025003486 FG-GAP repeat; Region: FG-GAP; cl15299 502025003487 FG-GAP repeat; Region: FG-GAP; cl15299 502025003488 FG-GAP repeat; Region: FG-GAP; cl15299 502025003489 FG-GAP repeat; Region: FG-GAP; cl15299 502025003490 Cupin domain; Region: Cupin_2; cl09118 502025003491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025003492 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025003493 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025003494 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 502025003495 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025003496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 502025003497 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 502025003498 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025003499 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 502025003500 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 502025003501 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025003502 amidase catalytic site [active] 502025003503 Zn binding residues [ion binding]; other site 502025003504 substrate binding site [chemical binding]; other site 502025003505 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 502025003506 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 502025003507 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 502025003508 classical (c) SDRs; Region: SDR_c; cd05233 502025003509 NAD(P) binding site [chemical binding]; other site 502025003510 active site 502025003511 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025003512 transcriptional regulator; Provisional; Region: PRK10632 502025003513 Helix-turn-helix domains; Region: HTH; cl00088 502025003514 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003515 putative effector binding pocket; other site 502025003516 dimerization interface [polypeptide binding]; other site 502025003517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025003518 Stage II sporulation protein; Region: SpoIID; pfam08486 502025003519 stage II sporulation protein D; Region: spore_II_D; TIGR02870 502025003520 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025003521 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003522 HEAT repeats; Region: HEAT_2; pfam13646 502025003523 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025003524 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 502025003525 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025003526 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 502025003527 putative active site [active] 502025003528 putative NTP binding site [chemical binding]; other site 502025003529 putative nucleic acid binding site [nucleotide binding]; other site 502025003530 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 502025003531 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025003532 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025003533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025003534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003536 active site 502025003537 ATP binding site [chemical binding]; other site 502025003538 substrate binding site [chemical binding]; other site 502025003539 activation loop (A-loop); other site 502025003540 translocation protein TolB; Provisional; Region: tolB; PRK03629 502025003541 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025003542 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025003543 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025003544 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025003545 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025003546 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003547 phosphopeptide binding site; other site 502025003548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003549 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003550 active site 502025003551 ATP binding site [chemical binding]; other site 502025003552 substrate binding site [chemical binding]; other site 502025003553 activation loop (A-loop); other site 502025003554 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025003555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003556 Walker A motif; other site 502025003557 ATP binding site [chemical binding]; other site 502025003558 Walker B motif; other site 502025003559 Integrase core domain; Region: rve; cl01316 502025003560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025003561 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025003562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003563 active site 502025003564 ATP binding site [chemical binding]; other site 502025003565 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003566 substrate binding site [chemical binding]; other site 502025003567 activation loop (A-loop); other site 502025003568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003569 Predicted ATPase [General function prediction only]; Region: COG3899 502025003570 Ferritin-like; Region: Ferritin-like; pfam12902 502025003571 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 502025003572 putative cation:proton antiport protein; Provisional; Region: PRK10669 502025003573 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 502025003574 AAA domain; Region: AAA_33; pfam13671 502025003575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003576 active site 502025003577 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 502025003578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025003579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025003580 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025003581 Protein kinase domain; Region: Pkinase; pfam00069 502025003582 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003583 active site 502025003584 substrate binding site [chemical binding]; other site 502025003585 ATP binding site [chemical binding]; other site 502025003586 activation loop (A-loop); other site 502025003587 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025003590 DNA binding residues [nucleotide binding] 502025003591 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 502025003592 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 502025003593 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003594 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025003595 Isochorismatase family; Region: Isochorismatase; pfam00857 502025003596 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025003597 catalytic triad [active] 502025003598 conserved cis-peptide bond; other site 502025003599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025003600 Integrase core domain; Region: rve; cl01316 502025003601 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 502025003602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025003603 FeS/SAM binding site; other site 502025003604 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025003605 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 502025003606 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 502025003607 putative sugar binding sites [chemical binding]; other site 502025003608 Q-X-W motif; other site 502025003609 Beta/Gamma crystallin; Region: Crystall; cl02528 502025003610 Beta/Gamma crystallin; Region: Crystall; cl02528 502025003611 Inositol 1,4,5-trisphosphate/ryanodine receptor; Region: Ins145_P3_rec; pfam08709 502025003612 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 502025003613 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025003614 B12 binding site [chemical binding]; other site 502025003615 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 502025003616 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025003617 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 502025003618 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 502025003619 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 502025003620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003621 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 502025003622 Helix-turn-helix domains; Region: HTH; cl00088 502025003623 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 502025003624 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 502025003625 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025003626 GXWXG protein; Region: GXWXG; pfam14231 502025003627 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 502025003628 Helix-turn-helix domains; Region: HTH; cl00088 502025003629 OsmC-like protein; Region: OsmC; cl00767 502025003630 Flagellin N-methylase; Region: FliB; cl00497 502025003631 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 502025003632 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 502025003633 active site 502025003634 nucleophile elbow; other site 502025003635 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025003636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025003637 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 502025003638 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 502025003639 FMN binding site [chemical binding]; other site 502025003640 active site 502025003641 substrate binding site [chemical binding]; other site 502025003642 catalytic residue [active] 502025003643 Helix-turn-helix domains; Region: HTH; cl00088 502025003644 LysR family transcriptional regulator; Provisional; Region: PRK14997 502025003645 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003646 putative effector binding pocket; other site 502025003647 dimerization interface [polypeptide binding]; other site 502025003648 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 502025003649 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025003650 NAD binding site [chemical binding]; other site 502025003651 homodimer interface [polypeptide binding]; other site 502025003652 homotetramer interface [polypeptide binding]; other site 502025003653 active site 502025003654 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 502025003655 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 502025003656 putative active site [active] 502025003657 putative substrate binding site [chemical binding]; other site 502025003658 ATP binding site [chemical binding]; other site 502025003659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003661 active site 502025003662 enoyl-CoA hydratase; Provisional; Region: PRK06688 502025003663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003664 substrate binding site [chemical binding]; other site 502025003665 oxyanion hole (OAH) forming residues; other site 502025003666 trimer interface [polypeptide binding]; other site 502025003667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003668 Helix-turn-helix domains; Region: HTH; cl00088 502025003669 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 502025003670 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025003671 dimer interface [polypeptide binding]; other site 502025003672 active site 502025003673 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025003674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003675 substrate binding site [chemical binding]; other site 502025003676 oxyanion hole (OAH) forming residues; other site 502025003677 trimer interface [polypeptide binding]; other site 502025003678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003679 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003680 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003682 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003683 active site 502025003684 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 502025003685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003686 substrate binding site [chemical binding]; other site 502025003687 oxyanion hole (OAH) forming residues; other site 502025003688 trimer interface [polypeptide binding]; other site 502025003689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003690 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003693 active site 502025003694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003695 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025003696 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025003697 active site 502025003698 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 502025003699 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 502025003700 catalytic Zn binding site [ion binding]; other site 502025003701 NAD binding site [chemical binding]; other site 502025003702 structural Zn binding site [ion binding]; other site 502025003703 GXWXG protein; Region: GXWXG; pfam14231 502025003704 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 502025003705 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025003706 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003707 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003708 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 502025003709 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 502025003710 active site 502025003711 Zn binding site [ion binding]; other site 502025003712 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 502025003713 Actin; Region: ACTIN; smart00268 502025003714 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cd00012 502025003715 ATP binding site [chemical binding]; other site 502025003716 gelsolin binding site; other site 502025003717 profilin binding site; other site 502025003718 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 502025003719 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025003720 oxidase reductase; Provisional; Region: PTZ00273 502025003721 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 502025003722 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025003723 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 502025003724 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 502025003725 metal binding site [ion binding]; metal-binding site 502025003726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025003727 S-adenosylmethionine binding site [chemical binding]; other site 502025003728 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025003729 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025003730 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 502025003731 [2Fe-2S] cluster binding site [ion binding]; other site 502025003732 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025003733 hydrophobic ligand binding site; other site 502025003734 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025003735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003736 NAD(P) binding site [chemical binding]; other site 502025003737 active site 502025003738 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 502025003739 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025003740 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025003741 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025003742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025003743 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 502025003744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003745 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025003746 NAD(P) binding site [chemical binding]; other site 502025003747 active site 502025003748 tetracycline repressor protein TetR; Provisional; Region: PRK13756 502025003749 Helix-turn-helix domains; Region: HTH; cl00088 502025003750 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 502025003751 Predicted ATPase [General function prediction only]; Region: COG4637 502025003752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003753 Walker A/P-loop; other site 502025003754 ATP binding site [chemical binding]; other site 502025003755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003756 ABC transporter signature motif; other site 502025003757 Walker B; other site 502025003758 D-loop; other site 502025003759 H-loop/switch region; other site 502025003760 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 502025003761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003762 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 502025003763 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025003764 putative NAD(P) binding site [chemical binding]; other site 502025003765 peptide synthase; Provisional; Region: PRK12316 502025003766 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003767 Thioesterase domain; Region: Thioesterase; pfam00975 502025003768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025003769 NRDE protein; Region: NRDE; cl01315 502025003770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025003771 ligand binding site [chemical binding]; other site 502025003772 flexible hinge region; other site 502025003773 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 502025003774 putative switch regulator; other site 502025003775 non-specific DNA interactions [nucleotide binding]; other site 502025003776 DNA binding site [nucleotide binding] 502025003777 sequence specific DNA binding site [nucleotide binding]; other site 502025003778 putative cAMP binding site [chemical binding]; other site 502025003779 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 502025003780 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025003781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025003782 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 502025003783 UreF; Region: UreF; pfam01730 502025003784 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 502025003785 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 502025003786 dimer interface [polypeptide binding]; other site 502025003787 catalytic residues [active] 502025003788 urease subunit alpha; Reviewed; Region: ureC; PRK13207 502025003789 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 502025003790 subunit interactions [polypeptide binding]; other site 502025003791 active site 502025003792 flap region; other site 502025003793 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 502025003794 gamma-beta subunit interface [polypeptide binding]; other site 502025003795 alpha-beta subunit interface [polypeptide binding]; other site 502025003796 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 502025003797 alpha-gamma subunit interface [polypeptide binding]; other site 502025003798 beta-gamma subunit interface [polypeptide binding]; other site 502025003799 UreD urease accessory protein; Region: UreD; cl00530 502025003800 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025003801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003802 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003803 active site 502025003804 ATP binding site [chemical binding]; other site 502025003805 substrate binding site [chemical binding]; other site 502025003806 activation loop (A-loop); other site 502025003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025003808 active site 502025003809 phosphorylation site [posttranslational modification] 502025003810 intermolecular recognition site; other site 502025003811 dimerization interface [polypeptide binding]; other site 502025003812 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025003813 CPxP motif; other site 502025003814 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025003815 CPxP motif; other site 502025003816 DsrE/DsrF-like family; Region: DrsE; cl00672 502025003817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003818 active site 502025003819 ATP binding site [chemical binding]; other site 502025003820 substrate binding site [chemical binding]; other site 502025003821 activation loop (A-loop); other site 502025003822 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025003823 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025003824 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 502025003825 Erythromycin esterase; Region: Erythro_esteras; pfam05139 502025003826 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025003827 putative active site [active] 502025003828 putative CoA binding site [chemical binding]; other site 502025003829 nudix motif; other site 502025003830 metal binding site [ion binding]; metal-binding site 502025003831 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 502025003832 Disintegrin; Region: Disintegrin; cl10507 502025003833 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003834 LysR family transcriptional regulator; Provisional; Region: PRK14997 502025003835 Helix-turn-helix domains; Region: HTH; cl00088 502025003836 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003837 putative effector binding pocket; other site 502025003838 dimerization interface [polypeptide binding]; other site 502025003839 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025003840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003841 NAD(P) binding site [chemical binding]; other site 502025003842 active site 502025003843 CHAT domain; Region: CHAT; pfam12770 502025003844 cyclase homology domain; Region: CHD; cd07302 502025003845 metal binding site [ion binding]; metal-binding site 502025003846 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003847 phosphopeptide binding site; other site 502025003848 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 502025003849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003850 Walker A motif; other site 502025003851 ATP binding site [chemical binding]; other site 502025003852 Walker B motif; other site 502025003853 arginine finger; other site 502025003854 Helix-turn-helix domains; Region: HTH; cl00088 502025003855 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003856 active site 502025003857 ATP binding site [chemical binding]; other site 502025003858 substrate binding site [chemical binding]; other site 502025003859 activation loop (A-loop); other site 502025003860 Thrombospondin C-terminal region; Region: TSP_C; pfam05735 502025003861 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025003862 ligand binding site [chemical binding]; other site 502025003863 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003864 active site 502025003865 ATP binding site [chemical binding]; other site 502025003866 substrate binding site [chemical binding]; other site 502025003867 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003868 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 502025003869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003871 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003874 DNA binding residues [nucleotide binding] 502025003875 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003876 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003877 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003878 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025003879 Annexin; Region: Annexin; cl02574 502025003880 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 502025003881 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 502025003882 putative active site [active] 502025003883 putative FMN binding site [chemical binding]; other site 502025003884 putative substrate binding site [chemical binding]; other site 502025003885 putative catalytic residue [active] 502025003886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003887 Helix-turn-helix domains; Region: HTH; cl00088 502025003888 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 502025003889 putative homodimer interface [polypeptide binding]; other site 502025003890 putative homotetramer interface [polypeptide binding]; other site 502025003891 putative allosteric switch controlling residues; other site 502025003892 putative metal binding site [ion binding]; other site 502025003893 putative homodimer-homodimer interface [polypeptide binding]; other site 502025003894 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 502025003895 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 502025003896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025003897 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025003898 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025003899 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025003900 HEAT repeats; Region: HEAT_2; pfam13646 502025003901 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 502025003902 acyl-CoA synthetase; Validated; Region: PRK05850 502025003903 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003904 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003905 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025003906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025003907 putative substrate translocation pore; other site 502025003908 peptide synthase; Provisional; Region: PRK12316 502025003909 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003910 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003911 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003912 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003913 peptide synthase; Provisional; Region: PRK12316 502025003914 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003915 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003916 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 502025003917 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003918 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003919 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003920 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003921 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003922 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003923 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003924 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 502025003925 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003926 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003927 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025003928 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003929 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003930 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003931 peptide synthase; Provisional; Region: PRK12467 502025003932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003933 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003934 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003935 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003936 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025003937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025003938 active site 502025003939 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025003940 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025003941 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003942 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025003943 inhibitor-cofactor binding pocket; inhibition site 502025003944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025003945 catalytic residue [active] 502025003946 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 502025003947 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 502025003948 Condensation domain; Region: Condensation; pfam00668 502025003949 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025003950 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003951 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003952 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025003954 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025003955 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 502025003956 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003957 phosphopeptide binding site; other site 502025003958 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003960 Walker A motif; other site 502025003961 ATP binding site [chemical binding]; other site 502025003962 Walker B motif; other site 502025003963 arginine finger; other site 502025003964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003965 active site 502025003966 ATP binding site [chemical binding]; other site 502025003967 substrate binding site [chemical binding]; other site 502025003968 activation loop (A-loop); other site 502025003969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003970 active site 502025003971 ATP binding site [chemical binding]; other site 502025003972 substrate binding site [chemical binding]; other site 502025003973 activation loop (A-loop); other site 502025003974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025003976 binding surface 502025003977 TPR motif; other site 502025003978 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025003979 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025003980 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025003981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025003982 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 502025003983 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025003984 PYR/PP interface [polypeptide binding]; other site 502025003985 dimer interface [polypeptide binding]; other site 502025003986 TPP binding site [chemical binding]; other site 502025003987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 502025003988 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 502025003989 TPP-binding site [chemical binding]; other site 502025003990 dimer interface [polypeptide binding]; other site 502025003991 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 502025003992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025003993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025003994 catalytic residue [active] 502025003995 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025003996 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025003997 AMP-binding enzyme; Region: AMP-binding; cl15778 502025003998 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 502025003999 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025004000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025004001 catalytic residue [active] 502025004002 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 502025004003 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025004004 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 502025004005 active site 502025004006 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025004007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025004008 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 502025004009 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025004010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025004011 active site 502025004012 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025004013 Protein of unknown function (DUF454); Region: DUF454; cl01063 502025004014 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025004015 FG-GAP repeat; Region: FG-GAP; cl15299 502025004016 FG-GAP repeat; Region: FG-GAP; cl15299 502025004017 FG-GAP repeat; Region: FG-GAP; cl15299 502025004018 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 502025004019 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025004020 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 502025004021 active site 502025004022 homodimer interface [polypeptide binding]; other site 502025004023 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 502025004024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025004025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004026 homodimer interface [polypeptide binding]; other site 502025004027 catalytic residue [active] 502025004028 polyphosphate kinase; Provisional; Region: PRK05443 502025004029 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 502025004030 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 502025004031 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 502025004032 putative domain interface [polypeptide binding]; other site 502025004033 putative active site [active] 502025004034 catalytic site [active] 502025004035 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025004036 putative active site [active] 502025004037 catalytic site [active] 502025004038 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025004039 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 502025004040 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 502025004041 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 502025004042 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 502025004043 aspartate kinase; Reviewed; Region: PRK06635 502025004044 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 502025004045 putative catalytic residues [active] 502025004046 putative nucleotide binding site [chemical binding]; other site 502025004047 putative aspartate binding site [chemical binding]; other site 502025004048 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 502025004049 active site 502025004050 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 502025004051 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 502025004052 homodimer interface [polypeptide binding]; other site 502025004053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004054 catalytic residue [active] 502025004055 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025004057 ATP binding site [chemical binding]; other site 502025004058 putative Mg++ binding site [ion binding]; other site 502025004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025004060 nucleotide binding region [chemical binding]; other site 502025004061 ATP-binding site [chemical binding]; other site 502025004062 tail fiber protein; Region: PHA00430 502025004063 PAS fold; Region: PAS_4; pfam08448 502025004064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025004065 putative active site [active] 502025004066 heme pocket [chemical binding]; other site 502025004067 PAS domain S-box; Region: sensory_box; TIGR00229 502025004068 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025004069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025004070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004071 dimer interface [polypeptide binding]; other site 502025004072 phosphorylation site [posttranslational modification] 502025004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004074 ATP binding site [chemical binding]; other site 502025004075 Mg2+ binding site [ion binding]; other site 502025004076 G-X-G motif; other site 502025004077 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004079 active site 502025004080 phosphorylation site [posttranslational modification] 502025004081 intermolecular recognition site; other site 502025004082 dimerization interface [polypeptide binding]; other site 502025004083 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 502025004084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025004085 DNA helicase II; Region: uvrD; TIGR01075 502025004086 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 502025004087 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025004088 active site 502025004089 Zn binding site [ion binding]; other site 502025004090 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 502025004091 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 502025004092 nudix motif; other site 502025004093 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 502025004094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004095 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 502025004096 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004098 active site 502025004099 phosphorylation site [posttranslational modification] 502025004100 intermolecular recognition site; other site 502025004101 dimerization interface [polypeptide binding]; other site 502025004102 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025004103 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025004104 ligand binding site [chemical binding]; other site 502025004105 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 502025004106 Pirin-related protein [General function prediction only]; Region: COG1741 502025004107 Cupin domain; Region: Cupin_2; cl09118 502025004108 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 502025004109 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025004110 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025004111 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025004112 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 502025004113 protein RecA; Region: tigrfam_recA; TIGR02012 502025004114 hexamer interface [polypeptide binding]; other site 502025004115 Walker A motif; other site 502025004116 ATP binding site [chemical binding]; other site 502025004117 Walker B motif; other site 502025004118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004120 active site 502025004121 ATP binding site [chemical binding]; other site 502025004122 substrate binding site [chemical binding]; other site 502025004123 activation loop (A-loop); other site 502025004124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004125 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004127 TPR motif; other site 502025004128 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025004129 binding surface 502025004130 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004131 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004132 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 502025004133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004134 AAA domain; Region: AAA_23; pfam13476 502025004135 Walker A/P-loop; other site 502025004136 ATP binding site [chemical binding]; other site 502025004137 Q-loop/lid; other site 502025004138 exonuclease subunit SbcC; Provisional; Region: PRK10246 502025004139 exonuclease subunit SbcC; Provisional; Region: PRK10246 502025004140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004141 Walker B; other site 502025004142 D-loop; other site 502025004143 H-loop/switch region; other site 502025004144 exonuclease subunit SbcD; Provisional; Region: PRK10966 502025004145 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 502025004146 active site 502025004147 metal binding site [ion binding]; metal-binding site 502025004148 DNA binding site [nucleotide binding] 502025004149 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 502025004150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025004151 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025004152 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025004153 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025004154 HipA N-terminal domain; Region: Couple_hipA; cl11853 502025004155 HipA-like N-terminal domain; Region: HipA_N; pfam07805 502025004156 HipA-like C-terminal domain; Region: HipA_C; pfam07804 502025004157 Protein of unknown function DUF262; Region: DUF262; cl14890 502025004158 Protein of unknown function DUF262; Region: DUF262; cl14890 502025004159 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 502025004160 active site 502025004161 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025004162 active site 502025004163 substrate binding sites [chemical binding]; other site 502025004164 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 502025004165 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 502025004166 FMN binding site [chemical binding]; other site 502025004167 active site 502025004168 catalytic residues [active] 502025004169 substrate binding site [chemical binding]; other site 502025004170 putative glutathione S-transferase; Provisional; Region: PRK10357 502025004171 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 502025004172 putative C-terminal domain interface [polypeptide binding]; other site 502025004173 putative GSH binding site (G-site) [chemical binding]; other site 502025004174 putative dimer interface [polypeptide binding]; other site 502025004175 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 502025004176 dimer interface [polypeptide binding]; other site 502025004177 N-terminal domain interface [polypeptide binding]; other site 502025004178 putative substrate binding pocket (H-site) [chemical binding]; other site 502025004179 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004180 AAA domain; Region: AAA_23; pfam13476 502025004181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004182 Walker A/P-loop; other site 502025004183 ATP binding site [chemical binding]; other site 502025004184 AAA domain; Region: AAA_21; pfam13304 502025004185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004186 ABC transporter signature motif; other site 502025004187 Walker B; other site 502025004188 D-loop; other site 502025004189 H-loop/switch region; other site 502025004190 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 502025004191 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 502025004192 active site 502025004193 HIGH motif; other site 502025004194 KMSKS motif; other site 502025004195 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 502025004196 tRNA binding surface [nucleotide binding]; other site 502025004197 anticodon binding site; other site 502025004198 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 502025004199 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025004200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004201 binding surface 502025004202 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025004203 TPR motif; other site 502025004204 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 502025004205 Helix-turn-helix domains; Region: HTH; cl00088 502025004206 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 502025004207 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025004208 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 502025004209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004210 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025004211 Sulfatase; Region: Sulfatase; cl10460 502025004212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025004213 dimerization interface [polypeptide binding]; other site 502025004214 cyclase homology domain; Region: CHD; cd07302 502025004215 nucleotidyl binding site; other site 502025004216 metal binding site [ion binding]; metal-binding site 502025004217 dimer interface [polypeptide binding]; other site 502025004218 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 502025004219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025004220 putative substrate translocation pore; other site 502025004221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 502025004222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025004223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004224 active site 502025004225 phosphorylation site [posttranslational modification] 502025004226 intermolecular recognition site; other site 502025004227 dimerization interface [polypeptide binding]; other site 502025004228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025004229 DNA binding residues [nucleotide binding] 502025004230 dimerization interface [polypeptide binding]; other site 502025004231 PAS fold; Region: PAS_4; pfam08448 502025004232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 502025004233 Histidine kinase; Region: HisKA_3; pfam07730 502025004234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004235 ATP binding site [chemical binding]; other site 502025004236 Mg2+ binding site [ion binding]; other site 502025004237 G-X-G motif; other site 502025004238 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 502025004239 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 502025004240 ATP-binding site [chemical binding]; other site 502025004241 Sugar specificity; other site 502025004242 Pyrimidine base specificity; other site 502025004243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004244 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 502025004245 NAD(P) binding site [chemical binding]; other site 502025004246 active site 502025004247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 502025004248 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 502025004249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025004250 active site 502025004251 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 502025004252 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 502025004253 ATP-binding site [chemical binding]; other site 502025004254 Gluconate-6-phosphate binding site [chemical binding]; other site 502025004255 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 502025004256 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025004257 active site 502025004258 N-formylglutamate amidohydrolase; Region: FGase; cl01522 502025004259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025004260 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 502025004261 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 502025004262 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025004263 carboxyltransferase (CT) interaction site; other site 502025004264 biotinylation site [posttranslational modification]; other site 502025004265 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 502025004266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025004267 ATP binding site [chemical binding]; other site 502025004268 putative Mg++ binding site [ion binding]; other site 502025004269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004270 Helicase associated domain (HA2); Region: HA2; cl04503 502025004271 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 502025004272 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 502025004273 Helix-turn-helix domains; Region: HTH; cl00088 502025004274 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 502025004275 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025004276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004277 NAD(P) binding site [chemical binding]; other site 502025004278 active site 502025004279 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004280 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004281 active site 502025004282 ATP binding site [chemical binding]; other site 502025004283 substrate binding site [chemical binding]; other site 502025004284 activation loop (A-loop); other site 502025004285 Predicted ATPase [General function prediction only]; Region: COG3899 502025004286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004287 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025004288 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025004289 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025004290 iron-sulfur cluster [ion binding]; other site 502025004291 [2Fe-2S] cluster binding site [ion binding]; other site 502025004292 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025004293 hydrophobic ligand binding site; other site 502025004294 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025004295 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025004296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025004297 Carboxylesterase family; Region: COesterase; pfam00135 502025004298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025004299 substrate binding pocket [chemical binding]; other site 502025004300 catalytic triad [active] 502025004301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025004302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004303 active site 502025004304 phosphorylation site [posttranslational modification] 502025004305 intermolecular recognition site; other site 502025004306 dimerization interface [polypeptide binding]; other site 502025004307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025004308 DNA binding site [nucleotide binding] 502025004309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025004310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004311 ATP binding site [chemical binding]; other site 502025004312 Mg2+ binding site [ion binding]; other site 502025004313 G-X-G motif; other site 502025004314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004316 active site 502025004317 ATP binding site [chemical binding]; other site 502025004318 substrate binding site [chemical binding]; other site 502025004319 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004320 substrate binding site [chemical binding]; other site 502025004321 activation loop (A-loop); other site 502025004322 activation loop (A-loop); other site 502025004323 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025004324 catalytic triad [active] 502025004325 alanine racemase; Reviewed; Region: alr; PRK00053 502025004326 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 502025004327 active site 502025004328 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025004329 dimer interface [polypeptide binding]; other site 502025004330 substrate binding site [chemical binding]; other site 502025004331 catalytic residues [active] 502025004332 Permease; Region: Permease; cl00510 502025004333 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025004334 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 502025004335 Walker A/P-loop; other site 502025004336 ATP binding site [chemical binding]; other site 502025004337 Q-loop/lid; other site 502025004338 ABC transporter signature motif; other site 502025004339 Walker B; other site 502025004340 D-loop; other site 502025004341 H-loop/switch region; other site 502025004342 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 502025004343 mce related protein; Region: MCE; pfam02470 502025004344 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 502025004345 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 502025004346 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 502025004347 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025004348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025004349 RNA binding surface [nucleotide binding]; other site 502025004350 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025004351 active site 502025004352 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 502025004353 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 502025004354 dimer interface [polypeptide binding]; other site 502025004355 putative functional site; other site 502025004356 putative MPT binding site; other site 502025004357 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 502025004358 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025004359 catalytic residue [active] 502025004360 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025004361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025004362 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 502025004363 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 502025004364 FOG: CBS domain [General function prediction only]; Region: COG0517 502025004365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 502025004366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004367 active site 502025004368 phosphorylation site [posttranslational modification] 502025004369 intermolecular recognition site; other site 502025004370 dimerization interface [polypeptide binding]; other site 502025004371 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 502025004372 cyclase homology domain; Region: CHD; cd07302 502025004373 nucleotidyl binding site; other site 502025004374 metal binding site [ion binding]; metal-binding site 502025004375 dimer interface [polypeptide binding]; other site 502025004376 Competence protein; Region: Competence; cl00471 502025004377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025004378 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 502025004379 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025004380 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 502025004381 dinuclear metal binding motif [ion binding]; other site 502025004382 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 502025004383 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 502025004384 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 502025004385 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 502025004386 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 502025004387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004388 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025004389 Bacterial SH3 domain; Region: SH3_3; cl02551 502025004390 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 502025004391 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004393 active site 502025004394 phosphorylation site [posttranslational modification] 502025004395 intermolecular recognition site; other site 502025004396 dimerization interface [polypeptide binding]; other site 502025004397 L-type amino acid transporter; Region: 2A0308; TIGR00911 502025004398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025004399 metal ion-dependent adhesion site (MIDAS); other site 502025004400 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 502025004401 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 502025004402 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025004403 FtsX-like permease family; Region: FtsX; cl15850 502025004404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025004405 putative acyl-acceptor binding pocket; other site 502025004406 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 502025004407 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 502025004408 putative dimer interface [polypeptide binding]; other site 502025004409 [2Fe-2S] cluster binding site [ion binding]; other site 502025004410 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 502025004411 SLBB domain; Region: SLBB; pfam10531 502025004412 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 502025004413 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 502025004414 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 502025004415 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 502025004416 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 502025004417 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025004418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025004419 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 502025004420 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 502025004421 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025004422 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 502025004423 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025004424 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 502025004425 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 502025004426 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 502025004427 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025004428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004429 dimer interface [polypeptide binding]; other site 502025004430 phosphorylation site [posttranslational modification] 502025004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004432 ATP binding site [chemical binding]; other site 502025004433 Mg2+ binding site [ion binding]; other site 502025004434 G-X-G motif; other site 502025004435 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004437 active site 502025004438 phosphorylation site [posttranslational modification] 502025004439 intermolecular recognition site; other site 502025004440 dimerization interface [polypeptide binding]; other site 502025004441 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025004442 dimer interface [polypeptide binding]; other site 502025004443 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025004444 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004445 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004446 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004447 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004448 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004449 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004450 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004451 Fibronectin type III-like domain; Region: Fn3-like; cl15273 502025004452 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004454 active site 502025004455 ATP binding site [chemical binding]; other site 502025004456 substrate binding site [chemical binding]; other site 502025004457 activation loop (A-loop); other site 502025004458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004459 Predicted ATPase [General function prediction only]; Region: COG3899 502025004460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025004461 dimerization interface [polypeptide binding]; other site 502025004462 putative DNA binding site [nucleotide binding]; other site 502025004463 putative Zn2+ binding site [ion binding]; other site 502025004464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025004465 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025004466 amidase; Provisional; Region: PRK08137 502025004467 Amidase; Region: Amidase; cl11426 502025004468 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 502025004469 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 502025004470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004471 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004472 active site 502025004473 ATP binding site [chemical binding]; other site 502025004474 substrate binding site [chemical binding]; other site 502025004475 activation loop (A-loop); other site 502025004476 Predicted ATPase [General function prediction only]; Region: COG3899 502025004477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025004478 GAF domain; Region: GAF; cl15785 502025004479 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004481 ATP binding site [chemical binding]; other site 502025004482 Mg2+ binding site [ion binding]; other site 502025004483 G-X-G motif; other site 502025004484 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025004485 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 502025004486 motif 1; other site 502025004487 active site 502025004488 motif 2; other site 502025004489 motif 3; other site 502025004490 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 502025004491 DHHA1 domain; Region: DHHA1; pfam02272 502025004492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025004493 ligand binding site [chemical binding]; other site 502025004494 Protein of unknown function, DUF481; Region: DUF481; cl01213 502025004495 FecR protein; Region: FecR; pfam04773 502025004496 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025004497 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 502025004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025004499 Septum formation initiator; Region: DivIC; cl11433 502025004500 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 502025004501 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 502025004502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025004503 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 502025004504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 502025004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 502025004506 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 502025004507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004512 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 502025004513 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 502025004514 Mg++ binding site [ion binding]; other site 502025004515 putative catalytic motif [active] 502025004516 putative substrate binding site [chemical binding]; other site 502025004517 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 502025004518 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004519 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004520 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 502025004521 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 502025004522 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 502025004523 active site 502025004524 metal binding site [ion binding]; metal-binding site 502025004525 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 502025004526 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025004527 RNA binding surface [nucleotide binding]; other site 502025004528 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 502025004529 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004530 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004531 active site 502025004532 ATP binding site [chemical binding]; other site 502025004533 substrate binding site [chemical binding]; other site 502025004534 activation loop (A-loop); other site 502025004535 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004537 Conserved TM helix; Region: TM_helix; pfam05552 502025004538 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025004539 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 502025004540 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025004541 inhibitor-cofactor binding pocket; inhibition site 502025004542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004543 catalytic residue [active] 502025004544 GAF domain; Region: GAF; cl15785 502025004545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004546 dimer interface [polypeptide binding]; other site 502025004547 phosphorylation site [posttranslational modification] 502025004548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004549 ATP binding site [chemical binding]; other site 502025004550 G-X-G motif; other site 502025004551 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004553 active site 502025004554 phosphorylation site [posttranslational modification] 502025004555 intermolecular recognition site; other site 502025004556 dimerization interface [polypeptide binding]; other site 502025004557 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025004558 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004559 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004560 conserved hypothetical protein; Region: TIGR02231 502025004561 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 502025004562 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025004564 active site 502025004565 intermolecular recognition site; other site 502025004566 dimerization interface [polypeptide binding]; other site 502025004567 Helix-turn-helix domains; Region: HTH; cl00088 502025004568 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025004569 Protein of unknown function DUF72; Region: DUF72; cl00777 502025004570 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004572 active site 502025004573 ATP binding site [chemical binding]; other site 502025004574 substrate binding site [chemical binding]; other site 502025004575 activation loop (A-loop); other site 502025004576 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004578 active site 502025004579 phosphorylation site [posttranslational modification] 502025004580 intermolecular recognition site; other site 502025004581 dimerization interface [polypeptide binding]; other site 502025004582 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 502025004583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025004584 metal binding site [ion binding]; metal-binding site 502025004585 active site 502025004586 I-site; other site 502025004587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025004588 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 502025004589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004590 active site 502025004591 ATP binding site [chemical binding]; other site 502025004592 substrate binding site [chemical binding]; other site 502025004593 activation loop (A-loop); other site 502025004594 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 502025004595 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004596 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 502025004597 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025004598 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025004599 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004600 Predicted permease [General function prediction only]; Region: COG2985 502025004601 Helix-turn-helix domains; Region: HTH; cl00088 502025004602 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 502025004603 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004606 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 502025004607 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025004608 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025004609 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025004610 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025004611 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 502025004612 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025004613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025004614 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025004615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025004616 catalytic loop [active] 502025004617 iron binding site [ion binding]; other site 502025004618 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025004619 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 502025004620 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 502025004621 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 502025004622 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 502025004623 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 502025004624 active site 502025004625 substrate-binding site [chemical binding]; other site 502025004626 metal-binding site [ion binding] 502025004627 ATP binding site [chemical binding]; other site 502025004628 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 502025004629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025004630 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 502025004631 putative deacylase active site [active] 502025004632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004633 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025004634 Walker A motif; other site 502025004635 ATP binding site [chemical binding]; other site 502025004636 Walker B motif; other site 502025004637 arginine finger; other site 502025004638 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 502025004639 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 502025004640 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 502025004641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025004642 DoxX; Region: DoxX; cl00976 502025004643 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025004644 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025004645 calcium binding site 2 [ion binding]; other site 502025004646 active site 502025004647 catalytic triad [active] 502025004648 calcium binding site 1 [ion binding]; other site 502025004649 hypothetical protein; Provisional; Region: PRK08317 502025004650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025004651 S-adenosylmethionine binding site [chemical binding]; other site 502025004652 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025004653 AMP-binding enzyme; Region: AMP-binding; cl15778 502025004654 AMP-binding enzyme; Region: AMP-binding; cl15778 502025004655 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025004656 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025004657 isochorismate synthase DhbC; Validated; Region: PRK06923 502025004658 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025004659 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 502025004660 AMP-binding enzyme; Region: AMP-binding; cl15778 502025004661 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004662 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 502025004663 Isochorismatase family; Region: Isochorismatase; pfam00857 502025004664 catalytic triad [active] 502025004665 conserved cis-peptide bond; other site 502025004666 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025004667 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 502025004668 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 502025004669 FAD binding pocket [chemical binding]; other site 502025004670 FAD binding motif [chemical binding]; other site 502025004671 phosphate binding motif [ion binding]; other site 502025004672 NAD binding pocket [chemical binding]; other site 502025004673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025004674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004675 NAD(P) binding site [chemical binding]; other site 502025004676 active site 502025004677 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025004678 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025004679 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025004680 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 502025004681 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025004682 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025004683 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025004684 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025004685 N-terminal plug; other site 502025004686 ligand-binding site [chemical binding]; other site 502025004687 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 502025004688 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 502025004689 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 502025004690 Protein of unknown function (DUF962); Region: DUF962; cl01879 502025004691 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 502025004692 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 502025004693 Walker A/P-loop; other site 502025004694 ATP binding site [chemical binding]; other site 502025004695 Q-loop/lid; other site 502025004696 ABC transporter signature motif; other site 502025004697 Walker B; other site 502025004698 D-loop; other site 502025004699 H-loop/switch region; other site 502025004700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025004701 dimer interface [polypeptide binding]; other site 502025004702 conserved gate region; other site 502025004703 putative PBP binding loops; other site 502025004704 ABC-ATPase subunit interface; other site 502025004705 NMT1-like family; Region: NMT1_2; cl15260 502025004706 NMT1/THI5 like; Region: NMT1; pfam09084 502025004707 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004708 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004709 active site 502025004710 ATP binding site [chemical binding]; other site 502025004711 substrate binding site [chemical binding]; other site 502025004712 activation loop (A-loop); other site 502025004713 Predicted ATPase [General function prediction only]; Region: COG3899 502025004714 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025004715 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004716 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025004717 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025004718 Walker A/P-loop; other site 502025004719 ATP binding site [chemical binding]; other site 502025004720 Q-loop/lid; other site 502025004721 ABC transporter signature motif; other site 502025004722 Walker B; other site 502025004723 D-loop; other site 502025004724 H-loop/switch region; other site 502025004725 CheB methylesterase; Region: CheB_methylest; pfam01339 502025004726 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004727 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004728 active site 502025004729 ATP binding site [chemical binding]; other site 502025004730 substrate binding site [chemical binding]; other site 502025004731 activation loop (A-loop); other site 502025004732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025004733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004734 TPR motif; other site 502025004735 TPR repeat; Region: TPR_11; pfam13414 502025004736 binding surface 502025004737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004738 binding surface 502025004739 TPR motif; other site 502025004740 TPR repeat; Region: TPR_11; pfam13414 502025004741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004742 binding surface 502025004743 TPR motif; other site 502025004744 TPR repeat; Region: TPR_11; pfam13414 502025004745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004746 binding surface 502025004747 TPR motif; other site 502025004748 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 502025004749 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025004750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004751 Walker A motif; other site 502025004752 ATP binding site [chemical binding]; other site 502025004753 Walker B motif; other site 502025004754 arginine finger; other site 502025004755 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 502025004756 putative active site [active] 502025004757 catalytic site [active] 502025004758 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 502025004759 putative active site [active] 502025004760 catalytic site [active] 502025004761 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025004762 phosphopeptide binding site; other site 502025004763 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025004764 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 502025004765 putative dimer interface [polypeptide binding]; other site 502025004766 putative active site [active] 502025004767 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 502025004768 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025004769 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025004770 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 502025004771 Uncharacterized conserved protein [Function unknown]; Region: COG2308 502025004772 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 502025004773 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025004774 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 502025004775 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025004776 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025004777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 502025004778 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025004779 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025004780 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025004781 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025004782 calcium binding site 2 [ion binding]; other site 502025004783 active site 502025004784 catalytic triad [active] 502025004785 calcium binding site 1 [ion binding]; other site 502025004786 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 502025004787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004788 Helix-turn-helix domains; Region: HTH; cl00088 502025004789 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 502025004790 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025004791 dimerization interface [polypeptide binding]; other site 502025004792 putative effector binding pocket; other site 502025004793 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 502025004794 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025004795 Sulfatase; Region: Sulfatase; cl10460 502025004796 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004797 active site 502025004798 ATP binding site [chemical binding]; other site 502025004799 substrate binding site [chemical binding]; other site 502025004800 activation loop (A-loop); other site 502025004801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004802 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 502025004803 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 502025004804 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 502025004805 putative active site [active] 502025004806 putative substrate binding site [chemical binding]; other site 502025004807 ATP binding site [chemical binding]; other site 502025004808 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 502025004809 Domain of unknown function DUF20; Region: UPF0118; pfam01594 502025004810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004811 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025004812 Walker A motif; other site 502025004813 ATP binding site [chemical binding]; other site 502025004814 Walker B motif; other site 502025004815 arginine finger; other site 502025004816 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025004817 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025004818 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025004819 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 502025004820 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 502025004821 putative NAD(P) binding site [chemical binding]; other site 502025004822 active site 502025004823 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 502025004824 NmrA-like family; Region: NmrA; pfam05368 502025004825 NADP binding site [chemical binding]; other site 502025004826 active site 502025004827 regulatory binding site [polypeptide binding]; other site 502025004828 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004830 active site 502025004831 phosphorylation site [posttranslational modification] 502025004832 intermolecular recognition site; other site 502025004833 dimerization interface [polypeptide binding]; other site 502025004834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004835 dimer interface [polypeptide binding]; other site 502025004836 phosphorylation site [posttranslational modification] 502025004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004838 ATP binding site [chemical binding]; other site 502025004839 Mg2+ binding site [ion binding]; other site 502025004840 G-X-G motif; other site 502025004841 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004843 active site 502025004844 phosphorylation site [posttranslational modification] 502025004845 intermolecular recognition site; other site 502025004846 dimerization interface [polypeptide binding]; other site 502025004847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004851 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025004852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004856 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025004857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025004861 GAF domain; Region: GAF_2; pfam13185 502025004862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004863 dimer interface [polypeptide binding]; other site 502025004864 phosphorylation site [posttranslational modification] 502025004865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004866 ATP binding site [chemical binding]; other site 502025004867 Mg2+ binding site [ion binding]; other site 502025004868 G-X-G motif; other site 502025004869 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004871 active site 502025004872 phosphorylation site [posttranslational modification] 502025004873 intermolecular recognition site; other site 502025004874 dimerization interface [polypeptide binding]; other site 502025004875 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004877 active site 502025004878 phosphorylation site [posttranslational modification] 502025004879 intermolecular recognition site; other site 502025004880 dimerization interface [polypeptide binding]; other site 502025004881 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004883 active site 502025004884 phosphorylation site [posttranslational modification] 502025004885 intermolecular recognition site; other site 502025004886 dimerization interface [polypeptide binding]; other site 502025004887 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025004888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025004889 CheB methylesterase; Region: CheB_methylest; pfam01339 502025004890 Cache domain; Region: Cache_1; pfam02743 502025004891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025004892 dimerization interface [polypeptide binding]; other site 502025004893 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025004894 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025004895 ligand binding site [chemical binding]; other site 502025004896 flexible hinge region; other site 502025004897 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 502025004898 putative switch regulator; other site 502025004899 non-specific DNA interactions [nucleotide binding]; other site 502025004900 DNA binding site [nucleotide binding] 502025004901 sequence specific DNA binding site [nucleotide binding]; other site 502025004902 putative cAMP binding site [chemical binding]; other site 502025004903 CAAX protease self-immunity; Region: Abi; cl00558 502025004904 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 502025004905 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 502025004906 trimer interface [polypeptide binding]; other site 502025004907 putative metal binding site [ion binding]; other site 502025004908 HEAT repeats; Region: HEAT_2; pfam13646 502025004909 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025004910 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025004911 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025004912 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025004913 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025004914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025004915 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025004916 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 502025004917 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 502025004918 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025004919 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025004920 Ycf48-like protein; Provisional; Region: PRK13684 502025004921 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 502025004922 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 502025004923 G1 box; other site 502025004924 putative GEF interaction site [polypeptide binding]; other site 502025004925 GTP/Mg2+ binding site [chemical binding]; other site 502025004926 Switch I region; other site 502025004927 G2 box; other site 502025004928 G3 box; other site 502025004929 Switch II region; other site 502025004930 G4 box; other site 502025004931 G5 box; other site 502025004932 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 502025004933 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 502025004934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 502025004935 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004936 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004937 active site 502025004938 ATP binding site [chemical binding]; other site 502025004939 substrate binding site [chemical binding]; other site 502025004940 activation loop (A-loop); other site 502025004941 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025004942 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025004943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025004944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025004945 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025004946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 502025004947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025004948 carboxyltransferase (CT) interaction site; other site 502025004949 biotinylation site [posttranslational modification]; other site 502025004950 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 502025004951 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025004952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025004953 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 502025004954 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025004955 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025004956 Transporter associated domain; Region: CorC_HlyC; cl08393 502025004957 CHAD domain; Region: CHAD; cl10506 502025004958 hypothetical protein; Provisional; Region: PRK05858 502025004959 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025004960 PYR/PP interface [polypeptide binding]; other site 502025004961 dimer interface [polypeptide binding]; other site 502025004962 TPP binding site [chemical binding]; other site 502025004963 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 502025004964 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 502025004965 TPP-binding site; other site 502025004966 dimer interface [polypeptide binding]; other site 502025004967 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025004968 putative ligand binding site [chemical binding]; other site 502025004969 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 502025004970 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 502025004971 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 502025004972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025004973 Coenzyme A binding pocket [chemical binding]; other site 502025004974 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025004975 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 502025004976 putative active site [active] 502025004977 catalytic triad [active] 502025004978 putative dimer interface [polypeptide binding]; other site 502025004979 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025004980 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 502025004981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025004982 FeS/SAM binding site; other site 502025004983 ATP cone domain; Region: ATP-cone; pfam03477 502025004984 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004985 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025004986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004987 NAD(P) binding site [chemical binding]; other site 502025004988 active site 502025004989 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025004990 FG-GAP repeat; Region: FG-GAP; cl15299 502025004991 FG-GAP repeat; Region: FG-GAP; cl15299 502025004992 FG-GAP repeat; Region: FG-GAP; cl15299 502025004993 FG-GAP repeat; Region: FG-GAP; cl15299 502025004994 FG-GAP repeat; Region: FG-GAP; cl15299 502025004995 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025004996 FG-GAP repeat; Region: FG-GAP; cl15299 502025004997 FG-GAP repeat; Region: FG-GAP; cl15299 502025004998 FG-GAP repeat; Region: FG-GAP; cl15299 502025004999 FG-GAP repeat; Region: FG-GAP; cl15299 502025005000 Phage Tail Collar Domain; Region: Collar; pfam07484 502025005001 feruloyl-CoA synthase; Reviewed; Region: PRK08180 502025005002 AMP-binding enzyme; Region: AMP-binding; cl15778 502025005003 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025005004 active site 502025005005 Zn binding site [ion binding]; other site 502025005006 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 502025005007 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 502025005008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025005009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025005010 homodimer interface [polypeptide binding]; other site 502025005011 catalytic residue [active] 502025005012 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025005013 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025005014 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 502025005015 active site 502025005016 metal binding site [ion binding]; metal-binding site 502025005017 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025005018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025005019 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 502025005020 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 502025005021 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 502025005022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005023 ATP binding site [chemical binding]; other site 502025005024 Mg2+ binding site [ion binding]; other site 502025005025 G-X-G motif; other site 502025005026 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 502025005027 anchoring element; other site 502025005028 dimer interface [polypeptide binding]; other site 502025005029 ATP binding site [chemical binding]; other site 502025005030 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 502025005031 active site 502025005032 putative metal-binding site [ion binding]; other site 502025005033 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 502025005034 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 502025005035 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 502025005036 CAP-like domain; other site 502025005037 active site 502025005038 primary dimer interface [polypeptide binding]; other site 502025005039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025005040 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025005041 Bacterial Ig-like domain; Region: Big_5; cl01012 502025005042 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 502025005043 MG2 domain; Region: A2M_N; pfam01835 502025005044 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 502025005045 Alpha-2-macroglobulin family; Region: A2M; pfam00207 502025005046 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 502025005047 surface patch; other site 502025005048 thioester region; other site 502025005049 specificity defining residues; other site 502025005050 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 502025005051 Transglycosylase; Region: Transgly; cl07896 502025005052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025005053 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025005054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025005055 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 502025005056 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 502025005057 putative active site [active] 502025005058 catalytic triad [active] 502025005059 putative dimer interface [polypeptide binding]; other site 502025005060 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025005061 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 502025005062 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 502025005063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025005064 TPR repeat; Region: TPR_11; pfam13414 502025005065 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025005066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005068 active site 502025005069 ATP binding site [chemical binding]; other site 502025005070 substrate binding site [chemical binding]; other site 502025005071 activation loop (A-loop); other site 502025005072 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025005073 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025005074 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025005075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025005076 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005077 phosphopeptide binding site; other site 502025005078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005080 active site 502025005081 ATP binding site [chemical binding]; other site 502025005082 substrate binding site [chemical binding]; other site 502025005083 activation loop (A-loop); other site 502025005084 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025005085 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025005086 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025005087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005088 S-adenosylmethionine binding site [chemical binding]; other site 502025005089 Uncharacterized conserved protein [Function unknown]; Region: COG3349 502025005090 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025005091 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025005092 [2Fe-2S] cluster binding site [ion binding]; other site 502025005093 iron-sulfur cluster [ion binding]; other site 502025005094 Dienelactone hydrolase family; Region: DLH; pfam01738 502025005095 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 502025005096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 502025005097 AAA domain; Region: AAA_33; pfam13671 502025005098 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005099 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 502025005100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025005101 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025005102 NlpC/P60 family; Region: NLPC_P60; cl11438 502025005103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005105 active site 502025005106 ATP binding site [chemical binding]; other site 502025005107 substrate binding site [chemical binding]; other site 502025005108 activation loop (A-loop); other site 502025005109 TPR repeat; Region: TPR_11; pfam13414 502025005110 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 502025005111 active site clefts [active] 502025005112 zinc binding site [ion binding]; other site 502025005113 dimer interface [polypeptide binding]; other site 502025005114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005116 active site 502025005117 ATP binding site [chemical binding]; other site 502025005118 substrate binding site [chemical binding]; other site 502025005119 activation loop (A-loop); other site 502025005120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005121 PAS domain; Region: PAS_9; pfam13426 502025005122 putative active site [active] 502025005123 heme pocket [chemical binding]; other site 502025005124 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 502025005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005126 dimer interface [polypeptide binding]; other site 502025005127 phosphorylation site [posttranslational modification] 502025005128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005129 active site 502025005130 phosphorylation site [posttranslational modification] 502025005131 intermolecular recognition site; other site 502025005132 dimerization interface [polypeptide binding]; other site 502025005133 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005135 active site 502025005136 phosphorylation site [posttranslational modification] 502025005137 intermolecular recognition site; other site 502025005138 dimerization interface [polypeptide binding]; other site 502025005139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005140 dimer interface [polypeptide binding]; other site 502025005141 phosphorylation site [posttranslational modification] 502025005142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005143 ATP binding site [chemical binding]; other site 502025005144 Mg2+ binding site [ion binding]; other site 502025005145 G-X-G motif; other site 502025005146 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 502025005147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025005148 Protein kinase domain; Region: Pkinase; pfam00069 502025005149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005150 active site 502025005151 ATP binding site [chemical binding]; other site 502025005152 substrate binding site [chemical binding]; other site 502025005153 activation loop (A-loop); other site 502025005154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005155 Predicted ATPase [General function prediction only]; Region: COG3899 502025005156 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025005157 GAF domain; Region: GAF; cl15785 502025005158 two component system sensor kinase SsrA; Provisional; Region: PRK15347 502025005159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005160 dimer interface [polypeptide binding]; other site 502025005161 phosphorylation site [posttranslational modification] 502025005162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005163 ATP binding site [chemical binding]; other site 502025005164 G-X-G motif; other site 502025005165 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005167 active site 502025005168 phosphorylation site [posttranslational modification] 502025005169 intermolecular recognition site; other site 502025005170 dimerization interface [polypeptide binding]; other site 502025005171 phenylhydantoinase; Validated; Region: PRK08323 502025005172 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 502025005173 tetramer interface [polypeptide binding]; other site 502025005174 active site 502025005175 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025005176 structural tetrad; other site 502025005177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005178 Walker A motif; other site 502025005179 ATP binding site [chemical binding]; other site 502025005180 Walker B motif; other site 502025005181 FAD binding domain; Region: FAD_binding_4; pfam01565 502025005182 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 502025005183 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 502025005184 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 502025005185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025005186 active site residue [active] 502025005187 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 502025005188 ATP binding site [chemical binding]; other site 502025005189 substrate interface [chemical binding]; other site 502025005190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005192 active site 502025005193 ATP binding site [chemical binding]; other site 502025005194 substrate binding site [chemical binding]; other site 502025005195 activation loop (A-loop); other site 502025005196 phosphodiesterase; Provisional; Region: PRK12704 502025005197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025005198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025005199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 502025005200 DNA binding residues [nucleotide binding] 502025005201 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025005202 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 502025005203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025005204 catalytic residue [active] 502025005205 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 502025005206 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025005207 active site 502025005208 Stringent starvation protein B; Region: SspB; cl01120 502025005209 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025005210 active site 502025005211 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 502025005212 active site 502025005213 catalytic residues [active] 502025005214 metal binding site [ion binding]; metal-binding site 502025005215 Domain of unknown function DUF59; Region: DUF59; cl00941 502025005216 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 502025005217 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 502025005218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025005219 active site 502025005220 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 502025005221 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 502025005222 binuclear metal center [ion binding]; other site 502025005223 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 502025005224 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025005225 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 502025005226 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025005227 OpgC protein; Region: OpgC_C; cl00792 502025005228 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025005229 active site 502025005230 catalytic triad [active] 502025005231 oxyanion hole [active] 502025005232 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 502025005233 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 502025005234 active site 502025005235 putative substrate binding pocket [chemical binding]; other site 502025005236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025005237 bile acid transporter; Region: bass; TIGR00841 502025005238 Membrane transport protein; Region: Mem_trans; cl09117 502025005239 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 502025005240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025005241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005242 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 502025005243 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025005244 substrate binding pocket [chemical binding]; other site 502025005245 substrate-Mg2+ binding site; other site 502025005246 aspartate-rich region 1; other site 502025005247 aspartate-rich region 2; other site 502025005248 phytoene desaturase; Region: crtI_fam; TIGR02734 502025005249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005250 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 502025005251 active site lid residues [active] 502025005252 substrate binding pocket [chemical binding]; other site 502025005253 catalytic residues [active] 502025005254 substrate-Mg2+ binding site; other site 502025005255 aspartate-rich region 1; other site 502025005256 aspartate-rich region 2; other site 502025005257 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 502025005258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025005259 DNA binding residues [nucleotide binding] 502025005260 B12 binding domain; Region: B12-binding_2; cl03653 502025005261 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 502025005262 B12 binding site [chemical binding]; other site 502025005263 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 502025005264 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005265 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005266 active site 502025005267 ATP binding site [chemical binding]; other site 502025005268 substrate binding site [chemical binding]; other site 502025005269 activation loop (A-loop); other site 502025005270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005271 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 502025005272 active site 502025005273 NTP binding site [chemical binding]; other site 502025005274 metal binding triad [ion binding]; metal-binding site 502025005275 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 502025005276 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005277 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005278 active site 502025005279 ATP binding site [chemical binding]; other site 502025005280 substrate binding site [chemical binding]; other site 502025005281 activation loop (A-loop); other site 502025005282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005283 PAS fold; Region: PAS_3; pfam08447 502025005284 putative active site [active] 502025005285 heme pocket [chemical binding]; other site 502025005286 PAS domain S-box; Region: sensory_box; TIGR00229 502025005287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005288 putative active site [active] 502025005289 heme pocket [chemical binding]; other site 502025005290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005291 dimer interface [polypeptide binding]; other site 502025005292 phosphorylation site [posttranslational modification] 502025005293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005294 ATP binding site [chemical binding]; other site 502025005295 Mg2+ binding site [ion binding]; other site 502025005296 G-X-G motif; other site 502025005297 two component system sensor kinase SsrA; Provisional; Region: PRK15347 502025005298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005299 active site 502025005300 phosphorylation site [posttranslational modification] 502025005301 intermolecular recognition site; other site 502025005302 dimerization interface [polypeptide binding]; other site 502025005303 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 502025005304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005306 active site 502025005307 ATP binding site [chemical binding]; other site 502025005308 substrate binding site [chemical binding]; other site 502025005309 activation loop (A-loop); other site 502025005310 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025005311 putative active site [active] 502025005312 putative metal binding site [ion binding]; other site 502025005313 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025005314 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 502025005315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005316 TIR domain; Region: TIR_2; cl15770 502025005317 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025005318 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 502025005319 putative lipid kinase; Reviewed; Region: PRK13057 502025005320 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025005321 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 502025005322 putative RNA binding site [nucleotide binding]; other site 502025005323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025005324 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025005325 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025005326 GAF domain; Region: GAF; cl15785 502025005327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005328 dimer interface [polypeptide binding]; other site 502025005329 phosphorylation site [posttranslational modification] 502025005330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005331 ATP binding site [chemical binding]; other site 502025005332 Mg2+ binding site [ion binding]; other site 502025005333 G-X-G motif; other site 502025005334 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 502025005335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025005336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005337 NAD(P) binding site [chemical binding]; other site 502025005338 active site 502025005339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005340 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005341 active site 502025005342 ATP binding site [chemical binding]; other site 502025005343 substrate binding site [chemical binding]; other site 502025005344 activation loop (A-loop); other site 502025005345 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 502025005346 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025005347 Walker A/P-loop; other site 502025005348 ATP binding site [chemical binding]; other site 502025005349 Q-loop/lid; other site 502025005350 ABC transporter signature motif; other site 502025005351 Walker B; other site 502025005352 D-loop; other site 502025005353 H-loop/switch region; other site 502025005354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025005355 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025005356 Walker A/P-loop; other site 502025005357 ATP binding site [chemical binding]; other site 502025005358 Q-loop/lid; other site 502025005359 ABC transporter signature motif; other site 502025005360 Walker B; other site 502025005361 D-loop; other site 502025005362 H-loop/switch region; other site 502025005363 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 502025005364 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 502025005365 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005366 enolase; Provisional; Region: eno; PRK00077 502025005367 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 502025005368 dimer interface [polypeptide binding]; other site 502025005369 metal binding site [ion binding]; metal-binding site 502025005370 substrate binding pocket [chemical binding]; other site 502025005371 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025005372 homoserine dehydrogenase; Provisional; Region: PRK06349 502025005373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005374 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 502025005375 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 502025005376 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 502025005377 putative active site [active] 502025005378 Right handed beta helix region; Region: Beta_helix; pfam13229 502025005379 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 502025005380 catalytic triad [active] 502025005381 conserved cis-peptide bond; other site 502025005382 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025005383 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025005384 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 502025005385 NAD(P) binding site [chemical binding]; other site 502025005386 16S rRNA methyltransferase B; Provisional; Region: PRK14901 502025005387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025005388 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 502025005389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005390 Walker A motif; other site 502025005391 ATP binding site [chemical binding]; other site 502025005392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025005394 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 502025005395 active site 502025005396 HslU subunit interaction site [polypeptide binding]; other site 502025005397 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 502025005398 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025005399 active site 502025005400 DNA binding site [nucleotide binding] 502025005401 Int/Topo IB signature motif; other site 502025005402 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 502025005403 putative FMN binding site [chemical binding]; other site 502025005404 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005406 active site 502025005407 phosphorylation site [posttranslational modification] 502025005408 intermolecular recognition site; other site 502025005409 dimerization interface [polypeptide binding]; other site 502025005410 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 502025005411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025005413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025005414 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 502025005415 Probable Catalytic site; other site 502025005416 metal-binding site 502025005417 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005418 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005419 calcium binding site 2 [ion binding]; other site 502025005420 active site 502025005421 catalytic triad [active] 502025005422 calcium binding site 1 [ion binding]; other site 502025005423 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025005424 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025005425 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005426 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005427 calcium binding site 2 [ion binding]; other site 502025005428 active site 502025005429 catalytic triad [active] 502025005430 calcium binding site 1 [ion binding]; other site 502025005431 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025005432 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025005433 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005434 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005435 calcium binding site 2 [ion binding]; other site 502025005436 active site 502025005437 catalytic triad [active] 502025005438 calcium binding site 1 [ion binding]; other site 502025005439 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025005440 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025005441 translocation protein TolB; Provisional; Region: tolB; PRK04922 502025005442 tellurite resistance protein terB; Region: terB; cd07176 502025005443 putative metal binding site [ion binding]; other site 502025005444 OPT oligopeptide transporter protein; Region: OPT; cl14607 502025005445 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 502025005446 active site 502025005447 ADP/pyrophosphate binding site [chemical binding]; other site 502025005448 dimerization interface [polypeptide binding]; other site 502025005449 allosteric effector site; other site 502025005450 fructose-1,6-bisphosphate binding site; other site 502025005451 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005452 Protein kinase domain; Region: Pkinase; pfam00069 502025005453 active site 502025005454 ATP binding site [chemical binding]; other site 502025005455 substrate binding site [chemical binding]; other site 502025005456 activation loop (A-loop); other site 502025005457 Predicted ATPase [General function prediction only]; Region: COG3899 502025005458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005459 GAF domain; Region: GAF_2; pfam13185 502025005460 GAF domain; Region: GAF; cl15785 502025005461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005463 ATP binding site [chemical binding]; other site 502025005464 Mg2+ binding site [ion binding]; other site 502025005465 G-X-G motif; other site 502025005466 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025005467 active site 502025005468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025005469 dimerization interface [polypeptide binding]; other site 502025005470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005471 dimer interface [polypeptide binding]; other site 502025005472 phosphorylation site [posttranslational modification] 502025005473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005474 ATP binding site [chemical binding]; other site 502025005475 Mg2+ binding site [ion binding]; other site 502025005476 G-X-G motif; other site 502025005477 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025005478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005479 active site 502025005480 phosphorylation site [posttranslational modification] 502025005481 intermolecular recognition site; other site 502025005482 dimerization interface [polypeptide binding]; other site 502025005483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005484 Walker A motif; other site 502025005485 ATP binding site [chemical binding]; other site 502025005486 Walker B motif; other site 502025005487 arginine finger; other site 502025005488 Helix-turn-helix domains; Region: HTH; cl00088 502025005489 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005491 active site 502025005492 phosphorylation site [posttranslational modification] 502025005493 intermolecular recognition site; other site 502025005494 dimerization interface [polypeptide binding]; other site 502025005495 probable polyamine oxidase; Region: PLN02268 502025005496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005498 Sulfatase; Region: Sulfatase; cl10460 502025005499 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025005500 Sulfatase; Region: Sulfatase; cl10460 502025005501 Sulfatase; Region: Sulfatase; cl10460 502025005502 Sulfatase; Region: Sulfatase; cl10460 502025005503 Sulfatase; Region: Sulfatase; cl10460 502025005504 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 502025005505 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 502025005506 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005507 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005508 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025005509 TM-ABC transporter signature motif; other site 502025005510 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 502025005511 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 502025005512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005513 Walker A/P-loop; other site 502025005514 ATP binding site [chemical binding]; other site 502025005515 Q-loop/lid; other site 502025005516 ABC transporter signature motif; other site 502025005517 Walker B; other site 502025005518 D-loop; other site 502025005519 H-loop/switch region; other site 502025005520 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 502025005521 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 502025005522 putative ligand binding site [chemical binding]; other site 502025005523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005524 S-adenosylmethionine binding site [chemical binding]; other site 502025005525 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 502025005526 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 502025005527 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 502025005528 homodimer interface [polypeptide binding]; other site 502025005529 metal binding site [ion binding]; metal-binding site 502025005530 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 502025005531 homodimer interface [polypeptide binding]; other site 502025005532 active site 502025005533 putative chemical substrate binding site [chemical binding]; other site 502025005534 metal binding site [ion binding]; metal-binding site 502025005535 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 502025005536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005537 GAF domain; Region: GAF; cl15785 502025005538 GAF domain; Region: GAF_2; pfam13185 502025005539 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 502025005540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025005541 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 502025005542 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 502025005543 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 502025005544 potential frameshift: common BLAST hit: gi|197121788|ref|YP_002133739.1| FAD dependent oxidoreductase 502025005545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005546 FAD dependent oxidoreductase; Region: DAO; pfam01266 502025005547 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 502025005548 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 502025005549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025005550 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 502025005551 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025005552 putative catalytic site [active] 502025005553 putative metal binding site [ion binding]; other site 502025005554 putative phosphate binding site [ion binding]; other site 502025005555 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025005556 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025005557 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025005558 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025005559 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025005560 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025005561 Uncharacterized conserved protein [Function unknown]; Region: COG3268 502025005562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005563 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025005564 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005565 phosphopeptide binding site; other site 502025005566 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025005567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025005568 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025005569 interface (dimer of trimers) [polypeptide binding]; other site 502025005570 Substrate-binding/catalytic site; other site 502025005571 Zn-binding sites [ion binding]; other site 502025005572 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 502025005573 Y-family of DNA polymerases; Region: PolY; cl12025 502025005574 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 502025005575 generic binding surface II; other site 502025005576 ssDNA binding site; other site 502025005577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025005578 putative Mg++ binding site [ion binding]; other site 502025005579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025005580 nucleotide binding region [chemical binding]; other site 502025005581 ATP-binding site [chemical binding]; other site 502025005582 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 502025005583 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 502025005584 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 502025005585 NHL repeat; Region: NHL; pfam01436 502025005586 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 502025005587 NHL repeat; Region: NHL; pfam01436 502025005588 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025005589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025005590 active site 502025005591 catalytic tetrad [active] 502025005592 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 502025005593 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 502025005594 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025005595 metal ion-dependent adhesion site (MIDAS); other site 502025005596 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025005597 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025005598 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 502025005599 active site 502025005600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025005601 classical (c) SDRs; Region: SDR_c; cd05233 502025005602 NAD(P) binding site [chemical binding]; other site 502025005603 active site 502025005604 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025005605 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025005606 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025005607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025005608 substrate binding site [chemical binding]; other site 502025005609 oxyanion hole (OAH) forming residues; other site 502025005610 trimer interface [polypeptide binding]; other site 502025005611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005612 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025005613 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025005614 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025005615 active site 502025005616 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 502025005617 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 502025005618 catalytic residues [active] 502025005619 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 502025005620 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025005621 active site 502025005622 NAD binding site [chemical binding]; other site 502025005623 metal binding site [ion binding]; metal-binding site 502025005624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025005625 Helix-turn-helix domains; Region: HTH; cl00088 502025005626 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025005627 substrate binding pocket [chemical binding]; other site 502025005628 dimerization interface [polypeptide binding]; other site 502025005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005630 S-adenosylmethionine binding site [chemical binding]; other site 502025005631 Sulfate transporter family; Region: Sulfate_transp; cl15842 502025005632 high affinity sulphate transporter 1; Region: sulP; TIGR00815 502025005633 Sulfate transporter family; Region: Sulfate_transp; cl15842 502025005634 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 502025005635 Predicted transporter component [General function prediction only]; Region: COG2391 502025005636 Sulphur transport; Region: Sulf_transp; cl01018 502025005637 Predicted transporter component [General function prediction only]; Region: COG2391 502025005638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025005639 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 502025005640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005641 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 502025005642 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 502025005643 active site 502025005644 NTP binding site [chemical binding]; other site 502025005645 metal binding triad [ion binding]; metal-binding site 502025005646 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 502025005647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005648 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025005649 Walker A motif; other site 502025005650 ATP binding site [chemical binding]; other site 502025005651 Walker B motif; other site 502025005652 arginine finger; other site 502025005653 Helix-turn-helix domains; Region: HTH; cl00088 502025005654 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 502025005655 putative FMN binding site [chemical binding]; other site 502025005656 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025005657 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025005658 putative C-terminal domain interface [polypeptide binding]; other site 502025005659 putative GSH binding site (G-site) [chemical binding]; other site 502025005660 putative dimer interface [polypeptide binding]; other site 502025005661 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025005662 N-terminal domain interface [polypeptide binding]; other site 502025005663 dimer interface [polypeptide binding]; other site 502025005664 substrate binding pocket (H-site) [chemical binding]; other site 502025005665 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025005666 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025005667 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025005668 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025005669 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005670 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005671 active site 502025005672 ATP binding site [chemical binding]; other site 502025005673 substrate binding site [chemical binding]; other site 502025005674 activation loop (A-loop); other site 502025005675 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 502025005676 metal binding site [ion binding]; metal-binding site 502025005677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005678 active site 502025005679 ATP binding site [chemical binding]; other site 502025005680 substrate binding site [chemical binding]; other site 502025005681 activation loop (A-loop); other site 502025005682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005683 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025005686 binding surface 502025005687 TPR motif; other site 502025005688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005692 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 502025005693 AMP-binding enzyme; Region: AMP-binding; cl15778 502025005694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025005695 TPR motif; other site 502025005696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025005697 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 502025005698 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 502025005699 active site 502025005700 dimer interface [polypeptide binding]; other site 502025005701 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 502025005702 dimer interface [polypeptide binding]; other site 502025005703 active site 502025005704 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005705 phosphopeptide binding site; other site 502025005706 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025005707 metal binding site [ion binding]; metal-binding site 502025005708 active site 502025005709 I-site; other site 502025005710 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025005711 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025005712 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025005713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005714 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 502025005715 PPIC-type PPIASE domain; Region: Rotamase; cl08278 502025005716 cytidylate kinase; Provisional; Region: cmk; PRK00023 502025005717 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 502025005718 CMP-binding site; other site 502025005719 The sites determining sugar specificity; other site 502025005720 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 502025005721 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 502025005722 RNA binding site [nucleotide binding]; other site 502025005723 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 502025005724 RNA binding site [nucleotide binding]; other site 502025005725 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 502025005726 RNA binding site [nucleotide binding]; other site 502025005727 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025005728 RNA binding site [nucleotide binding]; other site 502025005729 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 502025005730 RNA binding site [nucleotide binding]; other site 502025005731 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 502025005732 RNA binding site [nucleotide binding]; other site 502025005733 tetratricopeptide repeat protein; Provisional; Region: PRK11788 502025005734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005735 binding surface 502025005736 TPR motif; other site 502025005737 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 502025005738 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005739 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005740 active site 502025005741 ATP binding site [chemical binding]; other site 502025005742 substrate binding site [chemical binding]; other site 502025005743 activation loop (A-loop); other site 502025005744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 502025005745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005746 dimerization interface [polypeptide binding]; other site 502025005747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005748 dimer interface [polypeptide binding]; other site 502025005749 phosphorylation site [posttranslational modification] 502025005750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005751 ATP binding site [chemical binding]; other site 502025005752 Mg2+ binding site [ion binding]; other site 502025005753 G-X-G motif; other site 502025005754 homoserine kinase; Provisional; Region: PRK01212 502025005755 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 502025005756 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 502025005757 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 502025005758 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 502025005759 Preprotein translocase subunit; Region: YajC; cl00806 502025005760 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 502025005761 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 502025005762 Protein export membrane protein; Region: SecD_SecF; cl14618 502025005763 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 502025005764 Protein export membrane protein; Region: SecD_SecF; cl14618 502025005765 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 502025005766 DHH family; Region: DHH; pfam01368 502025005767 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 502025005768 Isochorismatase family; Region: Isochorismatase; pfam00857 502025005769 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025005770 catalytic triad [active] 502025005771 conserved cis-peptide bond; other site 502025005772 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 502025005773 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 502025005774 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 502025005775 Bacterial SH3 domain; Region: SH3_3; cl02551 502025005776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005777 Predicted ATPase [General function prediction only]; Region: COG3899 502025005778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005780 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005782 TPR motif; other site 502025005783 binding surface 502025005784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005785 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 502025005786 active site 502025005787 NTP binding site [chemical binding]; other site 502025005788 metal binding triad [ion binding]; metal-binding site 502025005789 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 502025005790 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025005791 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 502025005792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025005793 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 502025005794 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 502025005795 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 502025005796 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 502025005797 heme-binding residues [chemical binding]; other site 502025005798 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025005799 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025005800 molybdopterin cofactor binding site; other site 502025005801 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 502025005802 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 502025005803 4Fe-4S binding domain; Region: Fer4; cl02805 502025005804 Polysulphide reductase, NrfD; Region: NrfD; cl01295 502025005805 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 502025005806 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 502025005807 Cytochrome c; Region: Cytochrom_C; cl11414 502025005808 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025005809 Cu(I) binding site [ion binding]; other site 502025005810 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 502025005811 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 502025005812 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 502025005813 Cytochrome c; Region: Cytochrom_C; cl11414 502025005814 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 502025005815 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 502025005816 D-pathway; other site 502025005817 Low-spin heme binding site [chemical binding]; other site 502025005818 Putative water exit pathway; other site 502025005819 Binuclear center (active site) [active] 502025005820 K-pathway; other site 502025005821 Putative proton exit pathway; other site 502025005822 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 502025005823 Subunit I/III interface [polypeptide binding]; other site 502025005824 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 502025005825 Cupin domain; Region: Cupin_2; cl09118 502025005826 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025005827 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 502025005828 dimer interface [polypeptide binding]; other site 502025005829 substrate binding site [chemical binding]; other site 502025005830 ATP binding site [chemical binding]; other site 502025005831 Pantoate-beta-alanine ligase; Region: PanC; cd00560 502025005832 pantoate--beta-alanine ligase; Region: panC; TIGR00018 502025005833 active site 502025005834 ATP-binding site [chemical binding]; other site 502025005835 pantoate-binding site; other site 502025005836 HXXH motif; other site 502025005837 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 502025005838 oligomerization interface [polypeptide binding]; other site 502025005839 active site 502025005840 metal binding site [ion binding]; metal-binding site 502025005841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005842 TPR motif; other site 502025005843 binding surface 502025005844 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025005845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025005846 ligand binding site [chemical binding]; other site 502025005847 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 502025005848 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 502025005849 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 502025005850 active site 502025005851 Riboflavin kinase; Region: Flavokinase; cl03312 502025005852 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 502025005853 dihydrodipicolinate synthase; Region: dapA; TIGR00674 502025005854 dimer interface [polypeptide binding]; other site 502025005855 active site 502025005856 catalytic residue [active] 502025005857 dihydrodipicolinate reductase; Provisional; Region: PRK00048 502025005858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005859 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 502025005860 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 502025005861 Putative zinc ribbon domain; Region: DUF164; pfam02591 502025005862 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 502025005863 LexA repressor; Validated; Region: PRK00215 502025005864 Helix-turn-helix domains; Region: HTH; cl00088 502025005865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 502025005866 Catalytic site [active] 502025005867 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025005868 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 502025005869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005870 dimer interface [polypeptide binding]; other site 502025005871 phosphorylation site [posttranslational modification] 502025005872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005873 ATP binding site [chemical binding]; other site 502025005874 Mg2+ binding site [ion binding]; other site 502025005875 G-X-G motif; other site 502025005876 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025005877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005878 Walker A motif; other site 502025005879 ATP binding site [chemical binding]; other site 502025005880 Walker B motif; other site 502025005881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025005882 Walker A motif; other site 502025005883 ATP binding site [chemical binding]; other site 502025005884 Walker B motif; other site 502025005885 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025005886 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 502025005887 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025005888 putative active site [active] 502025005889 putative CoA binding site [chemical binding]; other site 502025005890 nudix motif; other site 502025005891 metal binding site [ion binding]; metal-binding site 502025005892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025005893 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025005894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025005895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025005896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025005897 Predicted acyl esterases [General function prediction only]; Region: COG2936 502025005898 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 502025005899 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 502025005900 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025005901 minor groove reading motif; other site 502025005902 helix-hairpin-helix signature motif; other site 502025005903 substrate binding pocket [chemical binding]; other site 502025005904 active site 502025005905 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 502025005906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025005907 RNA binding surface [nucleotide binding]; other site 502025005908 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025005909 active site 502025005910 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 502025005911 NAD-dependent deacetylase; Provisional; Region: PRK00481 502025005912 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 502025005913 putative active site [active] 502025005914 putative cosubstrate binding site; other site 502025005915 putative substrate binding site [chemical binding]; other site 502025005916 catalytic site [active] 502025005917 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025005918 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 502025005919 putative active site [active] 502025005920 metal binding site [ion binding]; metal-binding site 502025005921 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 502025005922 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 502025005923 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 502025005924 Walker A/P-loop; other site 502025005925 ATP binding site [chemical binding]; other site 502025005926 Q-loop/lid; other site 502025005927 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 502025005928 ABC transporter signature motif; other site 502025005929 Walker B; other site 502025005930 D-loop; other site 502025005931 H-loop/switch region; other site 502025005932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025005933 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 502025005934 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 502025005935 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 502025005936 active site 502025005937 Ca binding site [ion binding]; other site 502025005938 catalytic site [active] 502025005939 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 502025005940 Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810 502025005941 starch-binding site 2 [chemical binding]; other site 502025005942 starch-binding site 1 [chemical binding]; other site 502025005943 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 502025005944 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 502025005945 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025005946 active site 502025005947 metal binding site [ion binding]; metal-binding site 502025005948 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025005949 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 502025005950 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 502025005951 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 502025005952 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 502025005953 RimM N-terminal domain; Region: RimM; pfam01782 502025005954 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 502025005955 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 502025005956 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 502025005957 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 502025005958 Restriction endonuclease; Region: Mrr_cat; cl00516 502025005959 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025005960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005961 binding surface 502025005962 TPR motif; other site 502025005963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 502025005964 Tetratricopeptide repeat; Region: TPR_6; pfam13174 502025005965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005966 TPR motif; other site 502025005967 binding surface 502025005968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005969 binding surface 502025005970 TPR repeat; Region: TPR_11; pfam13414 502025005971 TPR motif; other site 502025005972 TPR repeat; Region: TPR_11; pfam13414 502025005973 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 502025005974 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 502025005975 Cl- selectivity filter; other site 502025005976 Cl- binding residues [ion binding]; other site 502025005977 pore gating glutamate residue; other site 502025005978 dimer interface [polypeptide binding]; other site 502025005979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 502025005980 FOG: CBS domain [General function prediction only]; Region: COG0517 502025005981 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 502025005982 MOFRL family; Region: MOFRL; pfam05161 502025005983 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 502025005984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005985 S-adenosylmethionine binding site [chemical binding]; other site 502025005986 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 502025005987 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025005988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025005989 FeS/SAM binding site; other site 502025005990 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025005991 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 502025005992 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025005993 catalytic residue [active] 502025005994 Protein kinase domain; Region: Pkinase; pfam00069 502025005995 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005996 active site 502025005997 ATP binding site [chemical binding]; other site 502025005998 substrate binding site [chemical binding]; other site 502025005999 activation loop (A-loop); other site 502025006000 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006001 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006002 active site 502025006003 ATP binding site [chemical binding]; other site 502025006004 substrate binding site [chemical binding]; other site 502025006005 activation loop (A-loop); other site 502025006006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006008 TPR motif; other site 502025006009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006010 binding surface 502025006011 TPR repeat; Region: TPR_11; pfam13414 502025006012 Nudix hydrolase homolog; Region: PLN02791 502025006013 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025006014 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025006015 Sulfatase; Region: Sulfatase; cl10460 502025006016 PA14 domain; Region: PA14; cl08459 502025006017 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025006018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006019 active site 502025006020 phosphorylation site [posttranslational modification] 502025006021 intermolecular recognition site; other site 502025006022 dimerization interface [polypeptide binding]; other site 502025006023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006024 Walker A motif; other site 502025006025 ATP binding site [chemical binding]; other site 502025006026 Walker B motif; other site 502025006027 arginine finger; other site 502025006028 Helix-turn-helix domains; Region: HTH; cl00088 502025006029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025006030 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 502025006031 Predicted methyltransferases [General function prediction only]; Region: COG0313 502025006032 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 502025006033 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 502025006034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025006035 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025006036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025006037 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 502025006038 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 502025006039 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 502025006040 protein binding site [polypeptide binding]; other site 502025006041 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 502025006042 Catalytic dyad [active] 502025006043 Bacterial SH3 domain; Region: SH3_3; cl02551 502025006044 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025006045 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 502025006046 putative active site [active] 502025006047 catalytic triad [active] 502025006048 putative dimer interface [polypeptide binding]; other site 502025006049 aminotransferase; Validated; Region: PRK07777 502025006050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025006051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025006052 homodimer interface [polypeptide binding]; other site 502025006053 catalytic residue [active] 502025006054 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025006055 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 502025006056 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006057 active site 502025006058 ATP binding site [chemical binding]; other site 502025006059 substrate binding site [chemical binding]; other site 502025006060 activation loop (A-loop); other site 502025006061 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006064 active site 502025006065 ATP binding site [chemical binding]; other site 502025006066 substrate binding site [chemical binding]; other site 502025006067 activation loop (A-loop); other site 502025006068 TPR repeat; Region: TPR_11; pfam13414 502025006069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025006070 binding surface 502025006071 TPR motif; other site 502025006072 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006073 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006074 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006075 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006076 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006077 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006078 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 502025006079 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 502025006080 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025006081 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025006082 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025006083 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 502025006084 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 502025006085 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 502025006086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025006087 active site 502025006088 Domain of unknown function (DUF427); Region: DUF427; cl00998 502025006089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025006090 Helix-turn-helix domains; Region: HTH; cl00088 502025006091 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025006092 substrate binding pocket [chemical binding]; other site 502025006093 dimerization interface [polypeptide binding]; other site 502025006094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006095 NmrA-like family; Region: NmrA; pfam05368 502025006096 NAD(P) binding site [chemical binding]; other site 502025006097 active site 502025006098 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 502025006099 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 502025006100 metal binding site [ion binding]; metal-binding site 502025006101 dimer interface [polypeptide binding]; other site 502025006102 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 502025006103 ligand binding site [chemical binding]; other site 502025006104 active site 502025006105 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 502025006106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025006107 ATP binding site [chemical binding]; other site 502025006108 putative Mg++ binding site [ion binding]; other site 502025006109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025006110 nucleotide binding region [chemical binding]; other site 502025006111 ATP-binding site [chemical binding]; other site 502025006112 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 502025006113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006114 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 502025006115 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 502025006116 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 502025006117 Ligand Binding Site [chemical binding]; other site 502025006118 TIGR00269 family protein; Region: TIGR00269 502025006119 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 502025006120 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 502025006121 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 502025006122 THUMP domain; Region: THUMP; cl12076 502025006123 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 502025006124 Ligand Binding Site [chemical binding]; other site 502025006125 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025006126 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 502025006127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025006128 catalytic residue [active] 502025006129 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 502025006130 HemN C-terminal domain; Region: HemN_C; pfam06969 502025006131 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 502025006132 Helix-turn-helix domains; Region: HTH; cl00088 502025006133 EamA-like transporter family; Region: EamA; cl01037 502025006134 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 502025006135 dimer interface [polypeptide binding]; other site 502025006136 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 502025006137 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025006138 Cell division protein FtsA; Region: FtsA; cl11496 502025006139 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025006140 HSP70 interaction site [polypeptide binding]; other site 502025006141 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025006142 substrate binding site [polypeptide binding]; other site 502025006143 dimer interface [polypeptide binding]; other site 502025006144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006145 dimer interface [polypeptide binding]; other site 502025006146 phosphorylation site [posttranslational modification] 502025006147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006148 ATP binding site [chemical binding]; other site 502025006149 Mg2+ binding site [ion binding]; other site 502025006150 G-X-G motif; other site 502025006151 Response regulator receiver domain; Region: Response_reg; pfam00072 502025006152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006153 active site 502025006154 phosphorylation site [posttranslational modification] 502025006155 intermolecular recognition site; other site 502025006156 dimerization interface [polypeptide binding]; other site 502025006157 Response regulator receiver domain; Region: Response_reg; pfam00072 502025006158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006159 active site 502025006160 phosphorylation site [posttranslational modification] 502025006161 intermolecular recognition site; other site 502025006162 dimerization interface [polypeptide binding]; other site 502025006163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025006164 putative binding surface; other site 502025006165 active site 502025006166 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 502025006167 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 502025006168 G1 box; other site 502025006169 GTP/Mg2+ binding site [chemical binding]; other site 502025006170 G2 box; other site 502025006171 Switch I region; other site 502025006172 G3 box; other site 502025006173 Switch II region; other site 502025006174 G4 box; other site 502025006175 G5 box; other site 502025006176 large tegument protein UL36; Provisional; Region: PHA03247 502025006177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006178 dimer interface [polypeptide binding]; other site 502025006179 phosphorylation site [posttranslational modification] 502025006180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006181 ATP binding site [chemical binding]; other site 502025006182 Mg2+ binding site [ion binding]; other site 502025006183 G-X-G motif; other site 502025006184 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025006185 FOG: CBS domain [General function prediction only]; Region: COG0517 502025006186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025006187 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 502025006188 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025006189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025006190 Transporter associated domain; Region: CorC_HlyC; cl08393 502025006191 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 502025006192 AIR carboxylase; Region: AIRC; cl00310 502025006193 Protein of unknown function DUF111; Region: DUF111; cl03398 502025006194 GAF domain; Region: GAF; cl15785 502025006195 PAS domain S-box; Region: sensory_box; TIGR00229 502025006196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006197 putative active site [active] 502025006198 heme pocket [chemical binding]; other site 502025006199 PAS domain S-box; Region: sensory_box; TIGR00229 502025006200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006201 putative active site [active] 502025006202 heme pocket [chemical binding]; other site 502025006203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006204 phosphorylation site [posttranslational modification] 502025006205 dimer interface [polypeptide binding]; other site 502025006206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006207 putative active site [active] 502025006208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006209 heme pocket [chemical binding]; other site 502025006210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006211 dimer interface [polypeptide binding]; other site 502025006212 phosphorylation site [posttranslational modification] 502025006213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006214 ATP binding site [chemical binding]; other site 502025006215 Mg2+ binding site [ion binding]; other site 502025006216 G-X-G motif; other site 502025006217 Pectinesterase; Region: Pectinesterase; cl01911 502025006218 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 502025006219 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025006220 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 502025006221 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 502025006222 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025006223 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025006224 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025006225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025006226 catalytic loop [active] 502025006227 iron binding site [ion binding]; other site 502025006228 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025006229 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025006230 MAPEG family; Region: MAPEG; cl09190 502025006231 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025006232 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 502025006233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025006234 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006235 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 502025006236 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025006237 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025006238 N-terminal plug; other site 502025006239 ligand-binding site [chemical binding]; other site 502025006240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 502025006241 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025006242 ligand binding site [chemical binding]; other site 502025006243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006244 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006245 active site 502025006246 ATP binding site [chemical binding]; other site 502025006247 substrate binding site [chemical binding]; other site 502025006248 activation loop (A-loop); other site 502025006249 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 502025006250 putative dimer interface [polypeptide binding]; other site 502025006251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006252 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025006253 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 502025006254 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 502025006255 putative active site [active] 502025006256 substrate binding site [chemical binding]; other site 502025006257 putative cosubstrate binding site; other site 502025006258 catalytic site [active] 502025006259 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 502025006260 substrate binding site [chemical binding]; other site 502025006261 16S rRNA methyltransferase B; Provisional; Region: PRK14902 502025006262 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 502025006263 putative RNA binding site [nucleotide binding]; other site 502025006264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025006265 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 502025006266 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 502025006267 FAD binding domain; Region: FAD_binding_1; pfam00667 502025006268 FAD binding pocket [chemical binding]; other site 502025006269 FAD binding motif [chemical binding]; other site 502025006270 catalytic residues [active] 502025006271 NAD binding pocket [chemical binding]; other site 502025006272 phosphate binding motif [ion binding]; other site 502025006273 beta-alpha-beta structure motif; other site 502025006274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025006275 Helix-turn-helix domains; Region: HTH; cl00088 502025006276 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 502025006277 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025006278 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025006279 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 502025006280 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 502025006281 substrate binding site [chemical binding]; other site 502025006282 hexamer interface [polypeptide binding]; other site 502025006283 metal binding site [ion binding]; metal-binding site 502025006284 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025006285 putative active site [active] 502025006286 catalytic site [active] 502025006287 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025006288 PLD-like domain; Region: PLDc_2; pfam13091 502025006289 putative active site [active] 502025006290 catalytic site [active] 502025006291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025006292 Helix-turn-helix domains; Region: HTH; cl00088 502025006293 AAA domain; Region: AAA_21; pfam13304 502025006294 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 502025006295 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 502025006296 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 502025006297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 502025006298 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 502025006299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 502025006300 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 502025006301 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 502025006302 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 502025006303 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 502025006304 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 502025006305 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 502025006306 phosphate binding site [ion binding]; other site 502025006307 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 502025006308 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025006309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006310 active site 502025006311 phosphorylation site [posttranslational modification] 502025006312 intermolecular recognition site; other site 502025006313 dimerization interface [polypeptide binding]; other site 502025006314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006315 Walker A motif; other site 502025006316 ATP binding site [chemical binding]; other site 502025006317 Walker B motif; other site 502025006318 arginine finger; other site 502025006319 Helix-turn-helix domains; Region: HTH; cl00088 502025006320 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 502025006321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025006322 type II secretion system protein D; Region: type_II_gspD; TIGR02517 502025006323 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006324 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006325 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006326 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 502025006327 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025006328 type II secretion system protein E; Region: type_II_gspE; TIGR02533 502025006329 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 502025006330 Walker A motif; other site 502025006331 ATP binding site [chemical binding]; other site 502025006332 Walker B motif; other site 502025006333 type II secretion system protein F; Region: GspF; TIGR02120 502025006334 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 502025006335 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 502025006336 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 502025006337 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 502025006338 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 502025006339 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 502025006340 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 502025006341 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 502025006342 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 502025006343 Cell division protein FtsA; Region: FtsA; cl11496 502025006344 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 502025006345 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 502025006346 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 502025006347 active site 502025006348 catalytic site [active] 502025006349 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 502025006350 Cupin domain; Region: Cupin_2; cl09118 502025006351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025006352 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025006353 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025006354 active site 502025006355 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 502025006356 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 502025006357 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 502025006358 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 502025006359 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 502025006360 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 502025006361 RNA binding site [nucleotide binding]; other site 502025006362 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 502025006363 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 502025006364 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 502025006365 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025006366 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 502025006367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025006368 FeS/SAM binding site; other site 502025006369 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025006370 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 502025006371 FMN binding site [chemical binding]; other site 502025006372 dimer interface [polypeptide binding]; other site 502025006373 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025006374 alanine dehydrogenase; Validated; Region: PRK06046 502025006375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006376 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 502025006377 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006379 active site 502025006380 ATP binding site [chemical binding]; other site 502025006381 substrate binding site [chemical binding]; other site 502025006382 activation loop (A-loop); other site 502025006383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006384 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006385 active site 502025006386 ATP binding site [chemical binding]; other site 502025006387 substrate binding site [chemical binding]; other site 502025006388 activation loop (A-loop); other site 502025006389 Predicted ATPase [General function prediction only]; Region: COG3899 502025006390 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 502025006391 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 502025006392 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025006393 phosphopeptide binding site; other site 502025006394 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025006395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006396 Walker A motif; other site 502025006397 ATP binding site [chemical binding]; other site 502025006398 Walker B motif; other site 502025006399 arginine finger; other site 502025006400 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006401 active site 502025006402 ATP binding site [chemical binding]; other site 502025006403 substrate binding site [chemical binding]; other site 502025006404 activation loop (A-loop); other site 502025006405 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025006406 catalytic residues [active] 502025006407 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 502025006408 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 502025006409 tetramer interface [polypeptide binding]; other site 502025006410 TPP-binding site [chemical binding]; other site 502025006411 heterodimer interface [polypeptide binding]; other site 502025006412 phosphorylation loop region [posttranslational modification] 502025006413 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 502025006414 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 502025006415 PYR/PP interface [polypeptide binding]; other site 502025006416 dimer interface [polypeptide binding]; other site 502025006417 TPP binding site [chemical binding]; other site 502025006418 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025006419 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 502025006420 putative active site [active] 502025006421 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025006422 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 502025006423 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025006424 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 502025006425 metal binding site [ion binding]; metal-binding site 502025006426 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025006427 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 502025006428 active site 502025006429 catalytic site [active] 502025006430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006431 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006432 active site 502025006433 ATP binding site [chemical binding]; other site 502025006434 substrate binding site [chemical binding]; other site 502025006435 activation loop (A-loop); other site 502025006436 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025006437 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 502025006438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006439 putative metal binding site [ion binding]; other site 502025006440 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025006441 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 502025006442 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025006443 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006444 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006445 active site 502025006446 ATP binding site [chemical binding]; other site 502025006447 substrate binding site [chemical binding]; other site 502025006448 activation loop (A-loop); other site 502025006449 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006450 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006451 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006452 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025006453 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025006454 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006455 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025006456 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006457 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025006459 catalytic loop [active] 502025006460 iron binding site [ion binding]; other site 502025006461 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 502025006462 active site 502025006463 DNA binding site [nucleotide binding] 502025006464 Protein kinase domain; Region: Pkinase; pfam00069 502025006465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006466 active site 502025006467 ATP binding site [chemical binding]; other site 502025006468 substrate binding site [chemical binding]; other site 502025006469 activation loop (A-loop); other site 502025006470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006472 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006473 active site 502025006474 ATP binding site [chemical binding]; other site 502025006475 substrate binding site [chemical binding]; other site 502025006476 activation loop (A-loop); other site 502025006477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006478 dimer interface [polypeptide binding]; other site 502025006479 phosphorylation site [posttranslational modification] 502025006480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006481 ATP binding site [chemical binding]; other site 502025006482 Mg2+ binding site [ion binding]; other site 502025006483 G-X-G motif; other site 502025006484 sensory histidine kinase DcuS; Provisional; Region: PRK11086 502025006485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006486 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 502025006487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006488 dimer interface [polypeptide binding]; other site 502025006489 phosphorylation site [posttranslational modification] 502025006490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006491 ATP binding site [chemical binding]; other site 502025006492 Mg2+ binding site [ion binding]; other site 502025006493 G-X-G motif; other site 502025006494 Response regulator receiver domain; Region: Response_reg; pfam00072 502025006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006496 active site 502025006497 phosphorylation site [posttranslational modification] 502025006498 intermolecular recognition site; other site 502025006499 dimerization interface [polypeptide binding]; other site 502025006500 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 502025006501 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025006502 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025006503 hydrophobic ligand binding site; other site 502025006504 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 502025006505 putative active site [active] 502025006506 nucleotide binding site [chemical binding]; other site 502025006507 nudix motif; other site 502025006508 putative metal binding site [ion binding]; other site 502025006509 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 502025006510 galactokinase; Provisional; Region: PRK05101 502025006511 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 502025006512 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 502025006513 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 502025006514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006515 NAD(P) binding site [chemical binding]; other site 502025006516 active site 502025006517 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025006518 active site 502025006519 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025006520 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025006521 NAD(P) binding site [chemical binding]; other site 502025006522 catalytic residues [active] 502025006523 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025006524 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025006525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025006526 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025006527 Integrase core domain; Region: rve; cl01316 502025006528 AIPR protein; Region: AIPR; pfam10592 502025006529 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 502025006530 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025006531 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025006532 active site 502025006533 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 502025006534 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 502025006535 FAD binding site [chemical binding]; other site 502025006536 substrate binding site [chemical binding]; other site 502025006537 catalytic base [active] 502025006538 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 502025006539 Subunit I/III interface [polypeptide binding]; other site 502025006540 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 502025006541 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 502025006542 D-pathway; other site 502025006543 Low-spin heme binding site [chemical binding]; other site 502025006544 Putative water exit pathway; other site 502025006545 Binuclear center (active site) [active] 502025006546 K-pathway; other site 502025006547 Putative proton exit pathway; other site 502025006548 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 502025006549 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 502025006550 Cytochrome c; Region: Cytochrom_C; cl11414 502025006551 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025006552 Cu(I) binding site [ion binding]; other site 502025006553 Cytochrome c; Region: Cytochrom_C; cl11414 502025006554 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 502025006555 Polysulphide reductase, NrfD; Region: NrfD; cl01295 502025006556 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025006557 molybdopterin cofactor binding site; other site 502025006558 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 502025006559 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 502025006560 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 502025006561 heme-binding residues [chemical binding]; other site 502025006562 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 502025006563 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025006564 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025006565 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 502025006566 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006567 active site 502025006568 ATP binding site [chemical binding]; other site 502025006569 substrate binding site [chemical binding]; other site 502025006570 activation loop (A-loop); other site 502025006571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006572 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 502025006573 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 502025006574 Protein of unknown function, DUF481; Region: DUF481; cl01213 502025006575 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025006577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025006578 Smr domain; Region: Smr; cl02619 502025006579 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 502025006580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025006581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025006582 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 502025006583 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 502025006584 metal binding site [ion binding]; metal-binding site 502025006585 dimer interface [polypeptide binding]; other site 502025006586 thioester reductase domain; Region: Thioester-redct; TIGR01746 502025006587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006588 NAD(P) binding site [chemical binding]; other site 502025006589 active site 502025006590 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 502025006591 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 502025006592 CoA-binding site [chemical binding]; other site 502025006593 ATP-binding [chemical binding]; other site 502025006594 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 502025006595 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025006596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006597 binding surface 502025006598 TPR motif; other site 502025006599 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 502025006600 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 502025006601 active site 502025006602 catalytic site [active] 502025006603 metal binding site [ion binding]; metal-binding site 502025006604 spermidine synthase; Provisional; Region: PRK03612 502025006605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025006606 Ion channel; Region: Ion_trans_2; cl11596 502025006607 voltage-gated potassium channel; Provisional; Region: PRK10537 502025006608 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 502025006609 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025006610 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 502025006611 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 502025006612 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025006613 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 502025006614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025006615 motif II; other site 502025006616 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 502025006617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025006618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006620 active site 502025006621 ATP binding site [chemical binding]; other site 502025006622 substrate binding site [chemical binding]; other site 502025006623 activation loop (A-loop); other site 502025006624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025006625 Predicted ATPase [General function prediction only]; Region: COG3899 502025006626 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025006627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025006628 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025006629 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 502025006630 CTP synthetase; Validated; Region: pyrG; PRK05380 502025006631 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 502025006632 Catalytic site [active] 502025006633 active site 502025006634 UTP binding site [chemical binding]; other site 502025006635 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 502025006636 active site 502025006637 putative oxyanion hole; other site 502025006638 catalytic triad [active] 502025006639 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025006640 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 502025006641 protein binding surface [polypeptide binding]; other site 502025006642 HEAT repeats; Region: HEAT_2; pfam13646 502025006643 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 502025006644 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 502025006645 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 502025006646 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 502025006647 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 502025006648 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 502025006649 30S subunit binding site; other site 502025006650 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025006651 active site 502025006652 phosphorylation site [posttranslational modification] 502025006653 HPr kinase/phosphorylase; Provisional; Region: PRK05428 502025006654 DRTGG domain; Region: DRTGG; cl12147 502025006655 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 502025006656 homohexamer subunit interaction site [polypeptide binding]; other site 502025006657 Hpr binding site; other site 502025006658 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 502025006659 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 502025006660 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 502025006661 dimerization domain swap beta strand [polypeptide binding]; other site 502025006662 regulatory protein interface [polypeptide binding]; other site 502025006663 active site 502025006664 regulatory phosphorylation site [posttranslational modification]; other site 502025006665 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 502025006666 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 502025006667 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 502025006668 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 502025006669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025006670 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 502025006671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006672 active site 502025006673 ATP binding site [chemical binding]; other site 502025006674 Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642 502025006675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006676 substrate binding site [chemical binding]; other site 502025006677 activation loop (A-loop); other site 502025006678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025006679 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006680 active site 502025006681 ATP binding site [chemical binding]; other site 502025006682 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006683 substrate binding site [chemical binding]; other site 502025006684 activation loop (A-loop); other site 502025006685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025006686 Predicted ATPase [General function prediction only]; Region: COG3899 502025006687 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025006688 active site 502025006689 DNA binding site [nucleotide binding] 502025006690 Int/Topo IB signature motif; other site 502025006691 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025006692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025006693 non-specific DNA binding site [nucleotide binding]; other site 502025006694 salt bridge; other site 502025006695 sequence-specific DNA binding site [nucleotide binding]; other site 502025006696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025006697 sequence-specific DNA binding site [nucleotide binding]; other site 502025006698 salt bridge; other site 502025006699 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025006700 phosphopeptide binding site; other site 502025006701 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006702 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006703 active site 502025006704 ATP binding site [chemical binding]; other site 502025006705 substrate binding site [chemical binding]; other site 502025006706 activation loop (A-loop); other site 502025006707 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 502025006708 TIR domain; Region: TIR_2; cl15770 502025006709 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025006710 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006711 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006712 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 502025006713 HsdM N-terminal domain; Region: HsdM_N; pfam12161 502025006714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025006715 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 502025006716 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025006717 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025006718 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 502025006719 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 502025006720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025006721 ATP binding site [chemical binding]; other site 502025006722 putative Mg++ binding site [ion binding]; other site 502025006723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025006724 nucleotide binding region [chemical binding]; other site 502025006725 ATP-binding site [chemical binding]; other site 502025006726 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 502025006727 Protein of unknown function DUF45; Region: DUF45; cl00636 502025006728 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025006729 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025006730 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025006731 catalytic residues [active] 502025006732 catalytic nucleophile [active] 502025006733 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025006734 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025006735 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025006736 Synaptic Site I dimer interface [polypeptide binding]; other site 502025006737 DNA binding site [nucleotide binding] 502025006738 Recombinase; Region: Recombinase; pfam07508 502025006739 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025006740 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025006741 TIGR02677 family protein; Region: TIGR02677 502025006742 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 502025006743 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 502025006744 TIGR02680 family protein; Region: TIGR02680 502025006745 TIGR02680 family protein; Region: TIGR02680 502025006746 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 502025006747 TIGR02679 family protein; Region: TIGR02679 502025006748 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 502025006749 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 502025006750 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025006751 active site 502025006752 catalytic residues [active] 502025006753 DNA binding site [nucleotide binding] 502025006754 Int/Topo IB signature motif; other site 502025006755 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 502025006756 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025006757 metal binding site [ion binding]; metal-binding site 502025006758 N-acetyltransferase; Region: Acetyltransf_2; cl00949 502025006759 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025006760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025006761 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 502025006762 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025006763 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025006764 putative active site pocket [active] 502025006765 dimerization interface [polypeptide binding]; other site 502025006766 putative catalytic residue [active] 502025006767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025006768 non-specific DNA binding site [nucleotide binding]; other site 502025006769 salt bridge; other site 502025006770 sequence-specific DNA binding site [nucleotide binding]; other site 502025006771 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006773 active site 502025006774 ATP binding site [chemical binding]; other site 502025006775 substrate binding site [chemical binding]; other site 502025006776 activation loop (A-loop); other site 502025006777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025006779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006780 TPR motif; other site 502025006781 binding surface 502025006782 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006783 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025006784 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025006785 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025006786 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025006787 Annexin; Region: Annexin; cl02574 502025006788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025006789 dimerization interface [polypeptide binding]; other site 502025006790 putative DNA binding site [nucleotide binding]; other site 502025006791 putative Zn2+ binding site [ion binding]; other site 502025006792 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 502025006793 Membrane transport protein; Region: Mem_trans; cl09117 502025006794 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025006795 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 502025006796 active site 502025006797 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 502025006798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006799 putative metal binding site [ion binding]; other site 502025006800 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 502025006801 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 502025006802 DNA binding residues [nucleotide binding] 502025006803 dimer interface [polypeptide binding]; other site 502025006804 mercury binding site [ion binding]; other site 502025006805 MerT mercuric transport protein; Region: MerT; cl03578 502025006806 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 502025006807 metal-binding site [ion binding] 502025006808 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 502025006809 Cation efflux family; Region: Cation_efflux; cl00316 502025006810 Cation efflux family; Region: Cation_efflux; cl00316 502025006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025006812 S-adenosylmethionine binding site [chemical binding]; other site 502025006813 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025006814 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025006815 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025006816 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025006817 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 502025006818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025006819 dimerization interface [polypeptide binding]; other site 502025006820 putative DNA binding site [nucleotide binding]; other site 502025006821 putative Zn2+ binding site [ion binding]; other site 502025006822 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025006823 putative active site pocket [active] 502025006824 dimerization interface [polypeptide binding]; other site 502025006825 putative catalytic residue [active] 502025006826 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025006827 putative active site pocket [active] 502025006828 dimerization interface [polypeptide binding]; other site 502025006829 putative catalytic residue [active] 502025006830 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025006831 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006832 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025006833 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006834 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006835 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006836 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 502025006837 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 502025006838 Protein of unknown function (DUF1399); Region: DUF1399; pfam07173 502025006839 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 502025006840 Mrr N-terminal domain; Region: Mrr_N; pfam14338 502025006841 Mrr N-terminal domain; Region: Mrr_N; pfam14338 502025006842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006843 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025006844 Walker A motif; other site 502025006845 ATP binding site [chemical binding]; other site 502025006846 Walker B motif; other site 502025006847 arginine finger; other site 502025006848 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025006849 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025006850 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025006851 catalytic residues [active] 502025006852 catalytic nucleophile [active] 502025006853 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025006854 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025006855 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025006856 Synaptic Site I dimer interface [polypeptide binding]; other site 502025006857 DNA binding site [nucleotide binding] 502025006858 Recombinase; Region: Recombinase; pfam07508 502025006859 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025006860 TIGR02677 family protein; Region: TIGR02677 502025006861 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 502025006862 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 502025006863 TIGR02680 family protein; Region: TIGR02680 502025006864 TIGR02680 family protein; Region: TIGR02680 502025006865 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 502025006866 TIGR02679 family protein; Region: TIGR02679 502025006867 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 502025006868 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 502025006869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006870 Walker A motif; other site 502025006871 ATP binding site [chemical binding]; other site 502025006872 Walker B motif; other site 502025006873 Integrase core domain; Region: rve; cl01316 502025006874 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025006875 active site 502025006876 catalytic residues [active] 502025006877 DNA binding site [nucleotide binding] 502025006878 Int/Topo IB signature motif; other site 502025006879 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 502025006880 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 502025006881 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025006882 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025006883 putative active site pocket [active] 502025006884 dimerization interface [polypeptide binding]; other site 502025006885 putative catalytic residue [active] 502025006886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025006887 non-specific DNA binding site [nucleotide binding]; other site 502025006888 salt bridge; other site 502025006889 sequence-specific DNA binding site [nucleotide binding]; other site 502025006890 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025006891 phosphopeptide binding site; other site 502025006892 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006893 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006894 active site 502025006895 ATP binding site [chemical binding]; other site 502025006896 substrate binding site [chemical binding]; other site 502025006897 activation loop (A-loop); other site 502025006898 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 502025006899 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025006900 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025006901 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025006902 Transposase, Mutator family; Region: Transposase_mut; pfam00872 502025006903 MULE transposase domain; Region: MULE; pfam10551 502025006904 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025006905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025006906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006907 Walker A motif; other site 502025006908 ATP binding site [chemical binding]; other site 502025006909 Walker B motif; other site 502025006910 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025006911 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025006912 putative active site pocket [active] 502025006913 dimerization interface [polypeptide binding]; other site 502025006914 putative catalytic residue [active] 502025006915 MAEBL; Provisional; Region: PTZ00121 502025006916 Transposase IS200 like; Region: Y1_Tnp; cl00848 502025006917 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025006918 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025006919 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025006920 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025006921 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 502025006922 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025006923 putative active site [active] 502025006924 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025006925 metal binding site [ion binding]; metal-binding site 502025006926 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025006927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025006928 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025006929 Annexin; Region: Annexin; cl02574 502025006930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006931 Walker A motif; other site 502025006932 ATP binding site [chemical binding]; other site 502025006933 Walker B motif; other site 502025006934 Helix-turn-helix domains; Region: HTH; cl00088 502025006935 Integrase core domain; Region: rve; cl01316 502025006936 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025006937 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025006938 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025006939 NAD(P) binding site [chemical binding]; other site 502025006940 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006941 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025006942 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 502025006943 dimer interface [polypeptide binding]; other site 502025006944 active site 502025006945 CoA binding pocket [chemical binding]; other site 502025006946 FkbH-like domain; Region: FkbH; TIGR01686 502025006947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025006948 active site 502025006949 motif I; other site 502025006950 motif II; other site 502025006951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025006952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025006953 active site 502025006954 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006955 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 502025006956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006957 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025006958 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025006959 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025006960 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025006962 Condensation domain; Region: Condensation; pfam00668 502025006963 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025006964 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025006965 AMP-binding enzyme; Region: AMP-binding; cl15778 502025006966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025006967 S-adenosylmethionine binding site [chemical binding]; other site 502025006968 peptide synthase; Provisional; Region: PRK12316 502025006969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006970 peptide synthase; Provisional; Region: PRK12467 502025006971 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025006972 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025006973 active site 502025006974 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025006975 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025006976 peptide synthase; Provisional; Region: PRK12467 502025006977 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006978 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025006979 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025006980 active site 502025006981 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025006982 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025006983 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 502025006984 NADP binding site [chemical binding]; other site 502025006985 active site 502025006986 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006987 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025006988 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025006989 active site 502025006990 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025006991 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025006992 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025006993 putative NADP binding site [chemical binding]; other site 502025006994 active site 502025006995 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025006996 Erythronolide synthase docking; Region: Docking; pfam08990 502025006997 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025006998 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025006999 active site 502025007000 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007001 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007002 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007003 putative NADP binding site [chemical binding]; other site 502025007004 active site 502025007005 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007006 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007008 active site 502025007009 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007010 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007011 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007012 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025007013 Enoylreductase; Region: PKS_ER; smart00829 502025007014 NAD(P) binding site [chemical binding]; other site 502025007015 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007016 putative NADP binding site [chemical binding]; other site 502025007017 active site 502025007018 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007019 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007020 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007021 active site 502025007022 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007023 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007024 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007025 putative NADP binding site [chemical binding]; other site 502025007026 active site 502025007027 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007029 active site 502025007030 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007031 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007032 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007033 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007034 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007035 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007036 putative NADP binding site [chemical binding]; other site 502025007037 active site 502025007038 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007039 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007040 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007041 active site 502025007042 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007043 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007044 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007045 putative NADP binding site [chemical binding]; other site 502025007046 active site 502025007047 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007048 Condensation domain; Region: Condensation; pfam00668 502025007049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025007050 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025007051 AMP-binding enzyme; Region: AMP-binding; cl15778 502025007052 acetate-CoA ligase; Region: PLN02654 502025007053 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007054 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 502025007055 Integrase core domain; Region: rve; cl01316 502025007056 Integrase core domain; Region: rve_3; cl15866 502025007057 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025007058 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025007059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007060 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025007061 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007062 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007063 Helix-turn-helix domains; Region: HTH; cl00088 502025007064 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025007065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025007066 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007067 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007068 active site 502025007069 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007070 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007071 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007073 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007074 putative NADP binding site [chemical binding]; other site 502025007075 active site 502025007076 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007077 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007078 active site 502025007079 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007080 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007081 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007082 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007083 putative NADP binding site [chemical binding]; other site 502025007084 active site 502025007085 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007086 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007087 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007088 active site 502025007089 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007090 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007091 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007092 putative NADP binding site [chemical binding]; other site 502025007093 active site 502025007094 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007095 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007096 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007097 active site 502025007098 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007100 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025007101 Enoylreductase; Region: PKS_ER; smart00829 502025007102 NAD(P) binding site [chemical binding]; other site 502025007103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007104 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007106 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007107 active site 502025007108 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007109 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007110 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007111 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007112 putative NADP binding site [chemical binding]; other site 502025007113 active site 502025007114 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007115 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007116 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007117 active site 502025007118 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007119 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007122 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007123 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007124 active site 502025007125 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007126 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007127 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007128 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007129 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007130 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025007131 Cytochrome P450; Region: p450; pfam00067 502025007132 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007133 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007134 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007135 active site 502025007136 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007137 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007138 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007139 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025007140 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007142 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007143 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007144 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007145 putative NADP binding site [chemical binding]; other site 502025007146 active site 502025007147 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007148 FAD binding domain; Region: FAD_binding_3; pfam01494 502025007149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007150 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025007151 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 502025007152 putative di-iron ligands [ion binding]; other site 502025007153 Cupin domain; Region: Cupin_2; cl09118 502025007154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025007155 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025007156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007157 NAD(P) binding site [chemical binding]; other site 502025007158 active site 502025007159 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 502025007160 active site 502025007161 zinc binding site [ion binding]; other site 502025007162 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 502025007163 30S subunit binding site; other site 502025007164 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 502025007165 Helix-turn-helix domains; Region: HTH; cl00088 502025007166 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 502025007167 putative dimerization interface [polypeptide binding]; other site 502025007168 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 502025007169 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025007170 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025007171 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025007172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007173 NAD(P) binding site [chemical binding]; other site 502025007174 active site 502025007175 L-lactate permease; Region: Lactate_perm; cl00701 502025007176 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025007177 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025007178 molybdopterin cofactor binding site; other site 502025007179 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 502025007180 molybdopterin cofactor binding site; other site 502025007181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025007182 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 502025007183 putative active site [active] 502025007184 putative FMN binding site [chemical binding]; other site 502025007185 putative substrate binding site [chemical binding]; other site 502025007186 putative catalytic residue [active] 502025007187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025007188 PAS fold; Region: PAS_4; pfam08448 502025007189 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025007190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007191 dimer interface [polypeptide binding]; other site 502025007192 phosphorylation site [posttranslational modification] 502025007193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007194 ATP binding site [chemical binding]; other site 502025007195 Mg2+ binding site [ion binding]; other site 502025007196 G-X-G motif; other site 502025007197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007198 active site 502025007199 phosphorylation site [posttranslational modification] 502025007200 intermolecular recognition site; other site 502025007201 dimerization interface [polypeptide binding]; other site 502025007202 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 502025007203 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 502025007204 putative active site [active] 502025007205 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025007206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007207 Walker A/P-loop; other site 502025007208 ATP binding site [chemical binding]; other site 502025007209 Q-loop/lid; other site 502025007210 ABC transporter signature motif; other site 502025007211 Walker B; other site 502025007212 D-loop; other site 502025007213 H-loop/switch region; other site 502025007214 HEXXH motif domain; Region: mod_HExxH; TIGR04267 502025007215 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 502025007216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025007217 FeS/SAM binding site; other site 502025007218 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025007219 Helix-turn-helix domains; Region: HTH; cl00088 502025007220 WHG domain; Region: WHG; pfam13305 502025007221 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 502025007222 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025007223 Cytochrome P450; Region: p450; pfam00067 502025007224 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 502025007225 KOW motif; Region: KOW; cl00354 502025007226 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 502025007227 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025007228 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007229 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 502025007230 Helix-turn-helix domains; Region: HTH; cl00088 502025007231 metal binding site 2 [ion binding]; metal-binding site 502025007232 putative DNA binding helix; other site 502025007233 metal binding site 1 [ion binding]; metal-binding site 502025007234 dimer interface [polypeptide binding]; other site 502025007235 structural Zn2+ binding site [ion binding]; other site 502025007236 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007237 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007238 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007239 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007241 active site 502025007242 ATP binding site [chemical binding]; other site 502025007243 substrate binding site [chemical binding]; other site 502025007244 activation loop (A-loop); other site 502025007245 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025007246 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025007247 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007248 structural tetrad; other site 502025007249 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007250 structural tetrad; other site 502025007251 Helix-turn-helix domains; Region: HTH; cl00088 502025007252 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 502025007253 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 502025007254 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025007255 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025007256 DNA binding residues [nucleotide binding] 502025007257 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 502025007258 A new structural DNA glycosylase; Region: AlkD_like; cd06561 502025007259 active site 502025007260 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 502025007261 homodimer interface [polypeptide binding]; other site 502025007262 substrate-cofactor binding pocket; other site 502025007263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025007264 catalytic residue [active] 502025007265 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025007266 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 502025007267 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025007268 NADP binding site [chemical binding]; other site 502025007269 Helix-turn-helix domains; Region: HTH; cl00088 502025007270 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 502025007271 acetyl-CoA synthetase; Provisional; Region: PRK04319 502025007272 Protein of unknown function (DUF770); Region: DUF770; cl01402 502025007273 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 502025007274 Protein of unknown function (DUF770); Region: DUF770; cl01402 502025007275 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 502025007276 Protein of unknown function (DUF877); Region: DUF877; pfam05943 502025007277 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 502025007278 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 502025007279 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 502025007280 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 502025007281 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 502025007282 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025007283 CotH protein; Region: CotH; pfam08757 502025007284 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025007285 calcium binding site 2 [ion binding]; other site 502025007286 active site 502025007287 catalytic triad [active] 502025007288 calcium binding site 1 [ion binding]; other site 502025007289 GON domain; Region: GON; pfam08685 502025007290 GON domain; Region: GON; pfam08685 502025007291 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 502025007292 active site 502025007293 metal binding site [ion binding]; metal-binding site 502025007294 homotetramer interface [polypeptide binding]; other site 502025007295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025007296 S-adenosylmethionine binding site [chemical binding]; other site 502025007297 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 502025007298 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 502025007299 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025007300 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 502025007301 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 502025007302 N- and C-terminal domain interface [polypeptide binding]; other site 502025007303 active site 502025007304 catalytic site [active] 502025007305 metal binding site [ion binding]; metal-binding site 502025007306 xylulose binding site [chemical binding]; other site 502025007307 ATP binding site [chemical binding]; other site 502025007308 putative homodimer interface [polypeptide binding]; other site 502025007309 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025007310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025007311 catalytic residue [active] 502025007312 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 502025007313 EamA-like transporter family; Region: EamA; cl01037 502025007314 EamA-like transporter family; Region: EamA; cl01037 502025007315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025007316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007317 binding surface 502025007318 TPR motif; other site 502025007319 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007320 metal ion-dependent adhesion site (MIDAS); other site 502025007321 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025007322 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007323 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025007324 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007325 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025007326 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007327 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025007328 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007329 hypothetical protein; Provisional; Region: PRK08244 502025007330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007331 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 502025007332 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025007333 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025007334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025007335 active site 502025007336 catalytic tetrad [active] 502025007337 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 502025007338 SCP-2 sterol transfer family; Region: SCP2; cl01225 502025007339 Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Region: PurD; COG0151 502025007340 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 502025007341 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025007342 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 502025007343 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007344 Beta/Gamma crystallin; Region: Crystall; cl02528 502025007345 Activator of aromatic catabolism; Region: XylR_N; pfam06505 502025007346 Heme NO binding; Region: HNOB; cl15268 502025007347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007348 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025007349 Walker A motif; other site 502025007350 ATP binding site [chemical binding]; other site 502025007351 Walker B motif; other site 502025007352 arginine finger; other site 502025007353 Helix-turn-helix domains; Region: HTH; cl00088 502025007354 Cupin domain; Region: Cupin_2; cl09118 502025007355 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 502025007356 Isochorismatase family; Region: Isochorismatase; pfam00857 502025007357 catalytic triad [active] 502025007358 dimer interface [polypeptide binding]; other site 502025007359 conserved cis-peptide bond; other site 502025007360 transcriptional regulator TraR; Provisional; Region: PRK13870 502025007361 Autoinducer binding domain; Region: Autoind_bind; pfam03472 502025007362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025007363 DNA binding residues [nucleotide binding] 502025007364 dimerization interface [polypeptide binding]; other site 502025007365 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007366 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007367 active site 502025007368 ATP binding site [chemical binding]; other site 502025007369 substrate binding site [chemical binding]; other site 502025007370 activation loop (A-loop); other site 502025007371 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007373 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025007374 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007375 structural tetrad; other site 502025007376 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025007377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007378 structural tetrad; other site 502025007379 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025007380 active site 502025007381 catalytic residues [active] 502025007382 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025007383 active site 502025007384 zinc binding site [ion binding]; other site 502025007385 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025007386 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl02844 502025007387 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 502025007388 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 502025007389 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025007390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025007391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025007392 DNA binding residues [nucleotide binding] 502025007393 Putative zinc-finger; Region: zf-HC2; cl15806 502025007394 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 502025007395 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025007396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007398 Walker A motif; other site 502025007399 Walker A motif; other site 502025007400 ATP binding site [chemical binding]; other site 502025007401 Walker B motif; other site 502025007402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007403 Walker A motif; other site 502025007404 ATP binding site [chemical binding]; other site 502025007405 Walker B motif; other site 502025007406 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 502025007407 tetramer interface [polypeptide binding]; other site 502025007408 dimer interface [polypeptide binding]; other site 502025007409 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025007410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007411 putative active site [active] 502025007412 heme pocket [chemical binding]; other site 502025007413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007414 dimer interface [polypeptide binding]; other site 502025007415 phosphorylation site [posttranslational modification] 502025007416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007417 ATP binding site [chemical binding]; other site 502025007418 Mg2+ binding site [ion binding]; other site 502025007419 G-X-G motif; other site 502025007420 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007422 active site 502025007423 phosphorylation site [posttranslational modification] 502025007424 intermolecular recognition site; other site 502025007425 dimerization interface [polypeptide binding]; other site 502025007426 Protein of unknown function (DUF805); Region: DUF805; cl01224 502025007427 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025007428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007429 Walker A motif; other site 502025007430 ATP binding site [chemical binding]; other site 502025007431 Walker B motif; other site 502025007432 arginine finger; other site 502025007433 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025007434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007435 Integral membrane protein DUF95; Region: DUF95; cl00572 502025007436 RDD family; Region: RDD; cl00746 502025007437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025007438 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 502025007439 MatE; Region: MatE; cl10513 502025007440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025007441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007442 Walker A/P-loop; other site 502025007443 ATP binding site [chemical binding]; other site 502025007444 Q-loop/lid; other site 502025007445 ABC transporter signature motif; other site 502025007446 Walker B; other site 502025007447 D-loop; other site 502025007448 H-loop/switch region; other site 502025007449 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025007450 Transcriptional regulators [Transcription]; Region: MarR; COG1846 502025007451 Helix-turn-helix domains; Region: HTH; cl00088 502025007452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007453 dimer interface [polypeptide binding]; other site 502025007454 phosphorylation site [posttranslational modification] 502025007455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007456 ATP binding site [chemical binding]; other site 502025007457 Mg2+ binding site [ion binding]; other site 502025007458 G-X-G motif; other site 502025007459 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007461 active site 502025007462 phosphorylation site [posttranslational modification] 502025007463 intermolecular recognition site; other site 502025007464 dimerization interface [polypeptide binding]; other site 502025007465 PAS fold; Region: PAS_3; pfam08447 502025007466 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 502025007467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025007469 putative active site [active] 502025007470 heme pocket [chemical binding]; other site 502025007471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007472 dimer interface [polypeptide binding]; other site 502025007473 phosphorylation site [posttranslational modification] 502025007474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007475 ATP binding site [chemical binding]; other site 502025007476 Mg2+ binding site [ion binding]; other site 502025007477 G-X-G motif; other site 502025007478 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007480 active site 502025007481 phosphorylation site [posttranslational modification] 502025007482 intermolecular recognition site; other site 502025007483 dimerization interface [polypeptide binding]; other site 502025007484 Uncharacterized conserved protein [Function unknown]; Region: COG3603 502025007485 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 502025007486 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 502025007487 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 502025007488 Walker A/P-loop; other site 502025007489 ATP binding site [chemical binding]; other site 502025007490 Q-loop/lid; other site 502025007491 ABC transporter signature motif; other site 502025007492 Walker B; other site 502025007493 D-loop; other site 502025007494 H-loop/switch region; other site 502025007495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025007496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025007497 dimer interface [polypeptide binding]; other site 502025007498 conserved gate region; other site 502025007499 putative PBP binding loops; other site 502025007500 ABC-ATPase subunit interface; other site 502025007501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025007502 dimer interface [polypeptide binding]; other site 502025007503 conserved gate region; other site 502025007504 putative PBP binding loops; other site 502025007505 ABC-ATPase subunit interface; other site 502025007506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025007507 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 502025007508 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 502025007509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025007510 ATP binding site [chemical binding]; other site 502025007511 putative Mg++ binding site [ion binding]; other site 502025007512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025007513 nucleotide binding region [chemical binding]; other site 502025007514 ATP-binding site [chemical binding]; other site 502025007515 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025007516 putative acyl-acceptor binding pocket; other site 502025007517 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 502025007518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007519 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 502025007520 TPR repeat; Region: TPR_11; pfam13414 502025007521 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025007522 ligand binding site [chemical binding]; other site 502025007523 flexible hinge region; other site 502025007524 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025007525 ligand binding site [chemical binding]; other site 502025007526 flexible hinge region; other site 502025007527 PII uridylyl-transferase; Provisional; Region: PRK05092 502025007528 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025007529 metal binding triad [ion binding]; metal-binding site 502025007530 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025007531 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 502025007532 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025007533 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025007534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025007535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007536 dimer interface [polypeptide binding]; other site 502025007537 phosphorylation site [posttranslational modification] 502025007538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007539 ATP binding site [chemical binding]; other site 502025007540 Mg2+ binding site [ion binding]; other site 502025007541 G-X-G motif; other site 502025007542 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007544 active site 502025007545 phosphorylation site [posttranslational modification] 502025007546 intermolecular recognition site; other site 502025007547 dimerization interface [polypeptide binding]; other site 502025007548 Protein of unknown function (DUF819); Region: DUF819; cl02317 502025007549 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025007550 FOG: CBS domain [General function prediction only]; Region: COG0517 502025007551 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025007552 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025007553 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025007554 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 502025007555 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025007556 catalytic residues [active] 502025007557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007558 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007559 active site 502025007560 ATP binding site [chemical binding]; other site 502025007561 substrate binding site [chemical binding]; other site 502025007562 activation loop (A-loop); other site 502025007563 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 502025007564 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 502025007565 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025007566 metal ion-dependent adhesion site (MIDAS); other site 502025007567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 502025007568 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 502025007569 MG2 domain; Region: A2M_N; pfam01835 502025007570 Alpha-2-macroglobulin family; Region: A2M; pfam00207 502025007571 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 502025007572 surface patch; other site 502025007573 thioester region; other site 502025007574 A-macroglobulin complement component; Region: A2M_comp; pfam07678 502025007575 specificity defining residues; other site 502025007576 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025007577 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 502025007578 NADP+ binding site [chemical binding]; other site 502025007579 folate binding site [chemical binding]; other site 502025007580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025007581 ATP binding site [chemical binding]; other site 502025007582 putative Mg++ binding site [ion binding]; other site 502025007583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025007584 nucleotide binding region [chemical binding]; other site 502025007585 ATP-binding site [chemical binding]; other site 502025007586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025007587 Ligand Binding Site [chemical binding]; other site 502025007588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025007589 Ligand Binding Site [chemical binding]; other site 502025007590 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025007591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025007592 binding surface 502025007593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025007594 TPR motif; other site 502025007595 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025007596 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007597 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025007598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007599 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 502025007600 Aerotolerance regulator N-terminal; Region: BatA; cl06567 502025007601 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025007603 DNA repair protein RadA; Provisional; Region: PRK11823 502025007604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007605 Walker A motif; other site 502025007606 ATP binding site [chemical binding]; other site 502025007607 Walker B motif; other site 502025007608 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025007609 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025007610 phosphopeptide binding site; other site 502025007611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 502025007612 substrate binding pocket [chemical binding]; other site 502025007613 Ion channel; Region: Ion_trans_2; cl11596 502025007614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 502025007615 membrane-bound complex binding site; other site 502025007616 hinge residues; other site 502025007617 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 502025007618 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 502025007619 dimer interface [polypeptide binding]; other site 502025007620 anticodon binding site; other site 502025007621 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 502025007622 homodimer interface [polypeptide binding]; other site 502025007623 motif 1; other site 502025007624 active site 502025007625 motif 2; other site 502025007626 GAD domain; Region: GAD; pfam02938 502025007627 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 502025007628 motif 3; other site 502025007629 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 502025007630 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 502025007631 ligand-binding site [chemical binding]; other site 502025007632 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 502025007633 Active Sites [active] 502025007634 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 502025007635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025007636 active site 502025007637 HIGH motif; other site 502025007638 nucleotide binding site [chemical binding]; other site 502025007639 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 502025007640 active site 502025007641 KMSKS motif; other site 502025007642 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 502025007643 tRNA binding surface [nucleotide binding]; other site 502025007644 anticodon binding site; other site 502025007645 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 502025007646 Sel1 repeat; Region: Sel1; cl02723 502025007647 Sel1 repeat; Region: Sel1; cl02723 502025007648 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 502025007649 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025007650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025007651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025007652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025007653 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025007654 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 502025007655 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541 502025007656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007657 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025007658 Walker A/P-loop; other site 502025007659 ATP binding site [chemical binding]; other site 502025007660 Q-loop/lid; other site 502025007661 ABC transporter signature motif; other site 502025007662 Walker B; other site 502025007663 D-loop; other site 502025007664 H-loop/switch region; other site 502025007665 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025007666 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 502025007667 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025007668 AMP-binding enzyme; Region: AMP-binding; cl15778 502025007669 AMP-binding enzyme; Region: AMP-binding; cl15778 502025007670 Conserved TM helix; Region: TM_helix; pfam05552 502025007671 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025007672 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025007673 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025007674 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 502025007675 NMT1-like family; Region: NMT1_2; cl15260 502025007676 NMT1/THI5 like; Region: NMT1; pfam09084 502025007677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007678 PAS fold; Region: PAS_3; pfam08447 502025007679 putative active site [active] 502025007680 heme pocket [chemical binding]; other site 502025007681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007682 dimer interface [polypeptide binding]; other site 502025007683 phosphorylation site [posttranslational modification] 502025007684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007685 ATP binding site [chemical binding]; other site 502025007686 Mg2+ binding site [ion binding]; other site 502025007687 G-X-G motif; other site 502025007688 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007690 active site 502025007691 phosphorylation site [posttranslational modification] 502025007692 intermolecular recognition site; other site 502025007693 dimerization interface [polypeptide binding]; other site 502025007694 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 502025007695 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 502025007696 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 502025007697 generic binding surface II; other site 502025007698 generic binding surface I; other site 502025007699 DNA Polymerase Y-family; Region: PolY_like; cd03468 502025007700 active site 502025007701 DNA binding site [nucleotide binding] 502025007702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025007703 Walker A motif; other site 502025007704 ATP binding site [chemical binding]; other site 502025007705 Walker B motif; other site 502025007706 Cytochrome c; Region: Cytochrom_C; cl11414 502025007707 serine O-acetyltransferase; Region: cysE; TIGR01172 502025007708 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 502025007709 trimer interface [polypeptide binding]; other site 502025007710 active site 502025007711 substrate binding site [chemical binding]; other site 502025007712 CoA binding site [chemical binding]; other site 502025007713 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007715 active site 502025007716 ATP binding site [chemical binding]; other site 502025007717 substrate binding site [chemical binding]; other site 502025007718 activation loop (A-loop); other site 502025007719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007720 TPR motif; other site 502025007721 binding surface 502025007722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025007723 putative acyl-acceptor binding pocket; other site 502025007724 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025007725 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025007726 putative NAD(P) binding site [chemical binding]; other site 502025007727 active site 502025007728 putative substrate binding site [chemical binding]; other site 502025007729 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 502025007730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007731 ATP binding site [chemical binding]; other site 502025007732 Mg2+ binding site [ion binding]; other site 502025007733 G-X-G motif; other site 502025007734 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 502025007735 ATP binding site [chemical binding]; other site 502025007736 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 502025007737 Protein of unknown function DUF45; Region: DUF45; cl00636 502025007738 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 502025007739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025007740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025007741 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 502025007742 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 502025007743 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 502025007744 homodimer interface [polypeptide binding]; other site 502025007745 NADP binding site [chemical binding]; other site 502025007746 substrate binding site [chemical binding]; other site 502025007747 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007749 active site 502025007750 phosphorylation site [posttranslational modification] 502025007751 intermolecular recognition site; other site 502025007752 dimerization interface [polypeptide binding]; other site 502025007753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007754 Walker A motif; other site 502025007755 ATP binding site [chemical binding]; other site 502025007756 Walker B motif; other site 502025007757 arginine finger; other site 502025007758 Helix-turn-helix domains; Region: HTH; cl00088 502025007759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007760 dimer interface [polypeptide binding]; other site 502025007761 phosphorylation site [posttranslational modification] 502025007762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007763 ATP binding site [chemical binding]; other site 502025007764 Mg2+ binding site [ion binding]; other site 502025007765 G-X-G motif; other site 502025007766 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 502025007767 Ca2+ binding site [ion binding]; other site 502025007768 EF-hand domain pair; Region: EF_hand_5; pfam13499 502025007769 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025007770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025007771 active site 502025007772 catalytic tetrad [active] 502025007773 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 502025007774 Family description; Region: VCBS; pfam13517 502025007775 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025007776 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 502025007777 dinuclear metal binding motif [ion binding]; other site 502025007778 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025007779 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025007780 DNA binding residues [nucleotide binding] 502025007781 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 502025007782 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 502025007783 FAD binding pocket [chemical binding]; other site 502025007784 FAD binding motif [chemical binding]; other site 502025007785 phosphate binding motif [ion binding]; other site 502025007786 beta-alpha-beta structure motif; other site 502025007787 NAD(p) ribose binding residues [chemical binding]; other site 502025007788 NAD binding pocket [chemical binding]; other site 502025007789 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 502025007790 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025007791 catalytic loop [active] 502025007792 iron binding site [ion binding]; other site 502025007793 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025007794 putative active site [active] 502025007795 putative metal binding site [ion binding]; other site 502025007796 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025007797 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007798 active site 502025007799 ATP binding site [chemical binding]; other site 502025007800 substrate binding site [chemical binding]; other site 502025007801 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007802 substrate binding site [chemical binding]; other site 502025007803 activation loop (A-loop); other site 502025007804 activation loop (A-loop); other site 502025007805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007807 TPR motif; other site 502025007808 binding surface 502025007809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007812 binding surface 502025007813 TPR motif; other site 502025007814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007815 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007817 binding surface 502025007818 TPR motif; other site 502025007819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025007822 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 502025007823 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 502025007824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025007825 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025007826 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 502025007827 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025007828 E3 interaction surface; other site 502025007829 lipoyl attachment site [posttranslational modification]; other site 502025007830 e3 binding domain; Region: E3_binding; pfam02817 502025007831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 502025007832 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 502025007833 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 502025007834 alpha subunit interface [polypeptide binding]; other site 502025007835 TPP binding site [chemical binding]; other site 502025007836 heterodimer interface [polypeptide binding]; other site 502025007837 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025007838 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 502025007839 TPP-binding site [chemical binding]; other site 502025007840 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 502025007841 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025007842 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025007843 IHF dimer interface [polypeptide binding]; other site 502025007844 IHF - DNA interface [nucleotide binding]; other site 502025007845 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025007846 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 502025007847 3D domain; Region: 3D; cl01439 502025007848 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 502025007849 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 502025007850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025007851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 502025007852 FIST N domain; Region: FIST; cl10701 502025007853 FIST C domain; Region: FIST_C; pfam10442 502025007854 TPR repeat; Region: TPR_11; pfam13414 502025007855 TPR repeat; Region: TPR_11; pfam13414 502025007856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007857 binding surface 502025007858 TPR motif; other site 502025007859 fatty acyl-CoA reductase; Region: PLN02996 502025007860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007861 NAD(P) binding site [chemical binding]; other site 502025007862 active site 502025007863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007864 active site 502025007865 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 502025007866 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025007867 AMP-binding enzyme; Region: AMP-binding; cl15778 502025007868 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025007869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025007870 putative acyl-acceptor binding pocket; other site 502025007871 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 502025007872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007873 NAD(P) binding site [chemical binding]; other site 502025007874 active site 502025007875 CheB methylesterase; Region: CheB_methylest; pfam01339 502025007876 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025007877 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025007878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025007879 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 502025007880 PAS domain; Region: PAS_10; pfam13596 502025007881 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025007882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007883 putative active site [active] 502025007884 heme pocket [chemical binding]; other site 502025007885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007886 dimer interface [polypeptide binding]; other site 502025007887 phosphorylation site [posttranslational modification] 502025007888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007889 ATP binding site [chemical binding]; other site 502025007890 Mg2+ binding site [ion binding]; other site 502025007891 G-X-G motif; other site 502025007892 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007894 active site 502025007895 phosphorylation site [posttranslational modification] 502025007896 intermolecular recognition site; other site 502025007897 dimerization interface [polypeptide binding]; other site 502025007898 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007900 active site 502025007901 phosphorylation site [posttranslational modification] 502025007902 intermolecular recognition site; other site 502025007903 dimerization interface [polypeptide binding]; other site 502025007904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 502025007905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007906 dimer interface [polypeptide binding]; other site 502025007907 phosphorylation site [posttranslational modification] 502025007908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007909 ATP binding site [chemical binding]; other site 502025007910 Mg2+ binding site [ion binding]; other site 502025007911 G-X-G motif; other site 502025007912 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 502025007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007914 phosphorylation site [posttranslational modification] 502025007915 intermolecular recognition site; other site 502025007916 CheB methylesterase; Region: CheB_methylest; pfam01339 502025007917 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025007918 putative binding surface; other site 502025007919 active site 502025007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007921 ATP binding site [chemical binding]; other site 502025007922 Mg2+ binding site [ion binding]; other site 502025007923 G-X-G motif; other site 502025007924 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025007925 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007927 active site 502025007928 phosphorylation site [posttranslational modification] 502025007929 intermolecular recognition site; other site 502025007930 dimerization interface [polypeptide binding]; other site 502025007931 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 502025007932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025007933 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025007934 dimer interface [polypeptide binding]; other site 502025007935 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 502025007936 putative CheW interface [polypeptide binding]; other site 502025007937 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025007938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025007939 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025007940 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 502025007941 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 502025007942 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541 502025007943 active site 502025007944 hydrophilic channel; other site 502025007945 dimerization interface [polypeptide binding]; other site 502025007946 catalytic residues [active] 502025007947 active site lid [active] 502025007948 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 502025007949 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007950 metal ion-dependent adhesion site (MIDAS); other site 502025007951 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 502025007952 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007954 metal ion-dependent adhesion site (MIDAS); other site 502025007955 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025007956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007957 Walker A motif; other site 502025007958 ATP binding site [chemical binding]; other site 502025007959 Walker B motif; other site 502025007960 arginine finger; other site 502025007961 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 502025007962 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 502025007963 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 502025007964 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 502025007965 Preprotein translocase SecG subunit; Region: SecG; cl09123 502025007966 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 502025007967 substrate binding site [chemical binding]; other site 502025007968 dimer interface [polypeptide binding]; other site 502025007969 catalytic triad [active] 502025007970 Phosphoglycerate kinase; Region: PGK; pfam00162 502025007971 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 502025007972 substrate binding site [chemical binding]; other site 502025007973 hinge regions; other site 502025007974 ADP binding site [chemical binding]; other site 502025007975 catalytic site [active] 502025007976 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 502025007977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007978 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 502025007979 PilZ domain; Region: PilZ; cl01260 502025007980 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 502025007981 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025007982 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025007983 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 502025007984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025007985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025007986 homodimer interface [polypeptide binding]; other site 502025007987 catalytic residue [active] 502025007988 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 502025007989 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 502025007990 catalytic motif [active] 502025007991 Zn binding site [ion binding]; other site 502025007992 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 502025007993 CheB methylesterase; Region: CheB_methylest; pfam01339 502025007994 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025007995 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025007996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025007997 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 502025007998 PAS domain; Region: PAS_10; pfam13596 502025007999 GAF domain; Region: GAF_2; pfam13185 502025008000 GAF domain; Region: GAF; cl15785 502025008001 GAF domain; Region: GAF_2; pfam13185 502025008002 PAS fold; Region: PAS_3; pfam08447 502025008003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008004 heme pocket [chemical binding]; other site 502025008005 putative active site [active] 502025008006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008007 PAS domain; Region: PAS_9; pfam13426 502025008008 putative active site [active] 502025008009 heme pocket [chemical binding]; other site 502025008010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008011 PAS domain; Region: PAS_9; pfam13426 502025008012 putative active site [active] 502025008013 heme pocket [chemical binding]; other site 502025008014 PAS domain S-box; Region: sensory_box; TIGR00229 502025008015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008016 putative active site [active] 502025008017 heme pocket [chemical binding]; other site 502025008018 PAS domain S-box; Region: sensory_box; TIGR00229 502025008019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008020 dimer interface [polypeptide binding]; other site 502025008021 phosphorylation site [posttranslational modification] 502025008022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008023 ATP binding site [chemical binding]; other site 502025008024 Mg2+ binding site [ion binding]; other site 502025008025 G-X-G motif; other site 502025008026 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008028 active site 502025008029 phosphorylation site [posttranslational modification] 502025008030 intermolecular recognition site; other site 502025008031 dimerization interface [polypeptide binding]; other site 502025008032 Domain of unknown function DUF59; Region: DUF59; cl00941 502025008033 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 502025008034 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 502025008035 trimerization site [polypeptide binding]; other site 502025008036 active site 502025008037 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025008038 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025008039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025008040 catalytic residue [active] 502025008041 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 502025008042 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 502025008043 FeS assembly ATPase SufC; Region: sufC; TIGR01978 502025008044 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 502025008045 Walker A/P-loop; other site 502025008046 ATP binding site [chemical binding]; other site 502025008047 Q-loop/lid; other site 502025008048 ABC transporter signature motif; other site 502025008049 Walker B; other site 502025008050 D-loop; other site 502025008051 H-loop/switch region; other site 502025008052 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 502025008053 putative ABC transporter; Region: ycf24; CHL00085 502025008054 Rrf2 family protein; Region: rrf2_super; TIGR00738 502025008055 Helix-turn-helix domains; Region: HTH; cl00088 502025008056 Helix-turn-helix domains; Region: HTH; cl00088 502025008057 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 502025008058 rRNA binding site [nucleotide binding]; other site 502025008059 predicted 30S ribosome binding site; other site 502025008060 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 502025008061 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 502025008062 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 502025008063 23S rRNA interface [nucleotide binding]; other site 502025008064 L7/L12 interface [polypeptide binding]; other site 502025008065 putative thiostrepton binding site; other site 502025008066 L25 interface [polypeptide binding]; other site 502025008067 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 502025008068 FMN binding site [chemical binding]; other site 502025008069 active site 502025008070 substrate binding site [chemical binding]; other site 502025008071 catalytic residue [active] 502025008072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025008073 Helix-turn-helix domains; Region: HTH; cl00088 502025008074 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025008075 putative effector binding pocket; other site 502025008076 dimerization interface [polypeptide binding]; other site 502025008077 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 502025008078 putative active site [active] 502025008079 metal binding site [ion binding]; metal-binding site 502025008080 phosphoserine phosphatase SerB; Region: serB; TIGR00338 502025008081 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025008082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025008083 motif II; other site 502025008084 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 502025008085 RF-1 domain; Region: RF-1; cl02875 502025008086 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008088 active site 502025008089 ATP binding site [chemical binding]; other site 502025008090 substrate binding site [chemical binding]; other site 502025008091 activation loop (A-loop); other site 502025008092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008093 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025008094 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025008095 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008096 structural tetrad; other site 502025008097 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008099 active site 502025008100 ATP binding site [chemical binding]; other site 502025008101 substrate binding site [chemical binding]; other site 502025008102 activation loop (A-loop); other site 502025008103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008104 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025008105 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008106 structural tetrad; other site 502025008107 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025008108 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008109 structural tetrad; other site 502025008110 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025008111 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025008112 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025008113 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 502025008114 lipoyl attachment site [posttranslational modification]; other site 502025008115 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 502025008116 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 502025008117 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 502025008118 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025008119 classical (c) SDRs; Region: SDR_c; cd05233 502025008120 NAD(P) binding site [chemical binding]; other site 502025008121 active site 502025008122 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025008123 nudix motif; other site 502025008124 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025008125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008126 active site 502025008127 phosphorylation site [posttranslational modification] 502025008128 intermolecular recognition site; other site 502025008129 dimerization interface [polypeptide binding]; other site 502025008130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008131 Walker A motif; other site 502025008132 ATP binding site [chemical binding]; other site 502025008133 Walker B motif; other site 502025008134 arginine finger; other site 502025008135 Helix-turn-helix domains; Region: HTH; cl00088 502025008136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025008137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008138 dimer interface [polypeptide binding]; other site 502025008139 phosphorylation site [posttranslational modification] 502025008140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008141 ATP binding site [chemical binding]; other site 502025008142 Mg2+ binding site [ion binding]; other site 502025008143 G-X-G motif; other site 502025008144 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025008145 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 502025008146 mce related protein; Region: MCE; pfam02470 502025008147 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 502025008148 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 502025008149 mce related protein; Region: MCE; pfam02470 502025008150 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 502025008151 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 502025008152 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025008153 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025008154 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025008155 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008156 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008157 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008158 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008159 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008160 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008161 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025008162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025008163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025008164 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025008165 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025008166 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025008167 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025008168 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025008169 Cellulose binding domain; Region: CBM_2; cl02709 502025008170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008172 active site 502025008173 ATP binding site [chemical binding]; other site 502025008174 substrate binding site [chemical binding]; other site 502025008175 activation loop (A-loop); other site 502025008176 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025008177 cyclase homology domain; Region: CHD; cd07302 502025008178 dimer interface [polypeptide binding]; other site 502025008179 nucleotidyl binding site; other site 502025008180 metal binding site [ion binding]; metal-binding site 502025008181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025008183 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 502025008184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025008185 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025008186 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025008187 FAD binding domain; Region: FAD_binding_4; pfam01565 502025008188 FAD binding domain; Region: FAD_binding_4; pfam01565 502025008189 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025008190 Zn binding site [ion binding]; other site 502025008191 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 502025008192 protein binding site [polypeptide binding]; other site 502025008193 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 502025008194 Biofilm formation and stress response factor; Region: BsmA; cl01794 502025008195 Family description; Region: VCBS; pfam13517 502025008196 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 502025008197 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 502025008198 putative DNA binding site [nucleotide binding]; other site 502025008199 putative homodimer interface [polypeptide binding]; other site 502025008200 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 502025008201 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 502025008202 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 502025008203 active site 502025008204 DNA binding site [nucleotide binding] 502025008205 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 502025008206 DNA binding site [nucleotide binding] 502025008207 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 502025008208 nucleotide binding site [chemical binding]; other site 502025008209 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008210 active site 502025008211 ATP binding site [chemical binding]; other site 502025008212 substrate binding site [chemical binding]; other site 502025008213 activation loop (A-loop); other site 502025008214 PrkA AAA domain; Region: AAA_PrkA; smart00763 502025008215 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 502025008216 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 502025008217 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 502025008218 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025008219 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025008220 active site 502025008221 metal binding site [ion binding]; metal-binding site 502025008222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025008223 Helix-turn-helix domains; Region: HTH; cl00088 502025008224 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025008225 substrate binding pocket [chemical binding]; other site 502025008226 dimerization interface [polypeptide binding]; other site 502025008227 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 502025008228 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 502025008229 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 502025008230 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 502025008231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025008232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008233 ATP binding site [chemical binding]; other site 502025008234 Mg2+ binding site [ion binding]; other site 502025008235 G-X-G motif; other site 502025008236 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 502025008237 putative hexamer interface [polypeptide binding]; other site 502025008238 putative hexagonal pore; other site 502025008239 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 502025008240 Hexamer interface [polypeptide binding]; other site 502025008241 Hexagonal pore residue; other site 502025008242 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 502025008243 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025008244 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025008245 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 502025008246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025008247 Ligand Binding Site [chemical binding]; other site 502025008248 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025008249 Protein phosphatase 2C; Region: PP2C; pfam00481 502025008250 active site 502025008251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008252 ligand binding site [chemical binding]; other site 502025008253 flexible hinge region; other site 502025008254 cyclase homology domain; Region: CHD; cd07302 502025008255 nucleotidyl binding site; other site 502025008256 metal binding site [ion binding]; metal-binding site 502025008257 dimer interface [polypeptide binding]; other site 502025008258 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 502025008259 cyclase homology domain; Region: CHD; cd07302 502025008260 nucleotidyl binding site; other site 502025008261 metal binding site [ion binding]; metal-binding site 502025008262 dimer interface [polypeptide binding]; other site 502025008263 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 502025008264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008265 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025008266 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025008267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025008268 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 502025008269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025008270 FeS/SAM binding site; other site 502025008271 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 502025008272 CcmE; Region: CcmE; cl00994 502025008273 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 502025008274 Cytochrome C biogenesis protein; Region: CcmH; cl01179 502025008275 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008276 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025008277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025008278 Walker A/P-loop; other site 502025008279 ATP binding site [chemical binding]; other site 502025008280 Q-loop/lid; other site 502025008281 ABC transporter signature motif; other site 502025008282 Walker B; other site 502025008283 D-loop; other site 502025008284 H-loop/switch region; other site 502025008285 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008286 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008287 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008288 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008289 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008290 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008291 CcmB protein; Region: CcmB; cl01016 502025008292 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 502025008293 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008295 active site 502025008296 ATP binding site [chemical binding]; other site 502025008297 substrate binding site [chemical binding]; other site 502025008298 activation loop (A-loop); other site 502025008299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025008300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025008301 active site 502025008302 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 502025008303 homodimer interface [polypeptide binding]; other site 502025008304 substrate-cofactor binding pocket; other site 502025008305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008306 catalytic residue [active] 502025008307 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008308 ligand binding site [chemical binding]; other site 502025008309 flexible hinge region; other site 502025008310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008311 ligand binding site [chemical binding]; other site 502025008312 flexible hinge region; other site 502025008313 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 502025008314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025008315 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 502025008316 motif 1; other site 502025008317 dimer interface [polypeptide binding]; other site 502025008318 active site 502025008319 motif 2; other site 502025008320 motif 3; other site 502025008321 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 502025008322 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025008323 pyruvate phosphate dikinase; Provisional; Region: PRK09279 502025008324 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025008325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 502025008326 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 502025008327 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025008328 Sporulation related domain; Region: SPOR; cl10051 502025008329 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025008330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008331 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 502025008332 Walker A/P-loop; other site 502025008333 ATP binding site [chemical binding]; other site 502025008334 Q-loop/lid; other site 502025008335 ABC transporter signature motif; other site 502025008336 Walker B; other site 502025008337 D-loop; other site 502025008338 H-loop/switch region; other site 502025008339 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025008340 amidase catalytic site [active] 502025008341 Zn binding residues [ion binding]; other site 502025008342 substrate binding site [chemical binding]; other site 502025008343 hypothetical protein; Provisional; Region: PRK06148 502025008344 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025008345 metal ion-dependent adhesion site (MIDAS); other site 502025008346 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008347 phosphopeptide binding site; other site 502025008348 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 502025008349 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008350 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008351 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008352 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 502025008353 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025008354 putative RNA binding site [nucleotide binding]; other site 502025008355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025008356 Protein of unknown function (DUF620); Region: DUF620; pfam04788 502025008357 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025008358 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025008359 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025008360 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025008361 Transglycosylase; Region: Transgly; cl07896 502025008362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025008363 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025008364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008365 binding surface 502025008366 TPR motif; other site 502025008367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008368 TPR motif; other site 502025008369 binding surface 502025008370 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008371 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008372 active site 502025008373 ATP binding site [chemical binding]; other site 502025008374 substrate binding site [chemical binding]; other site 502025008375 activation loop (A-loop); other site 502025008376 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 502025008377 recombination factor protein RarA; Reviewed; Region: PRK13342 502025008378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008379 Walker A motif; other site 502025008380 ATP binding site [chemical binding]; other site 502025008381 Walker B motif; other site 502025008382 arginine finger; other site 502025008383 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 502025008384 NMT1-like family; Region: NMT1_2; cl15260 502025008385 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 502025008386 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025008387 substrate binding pocket [chemical binding]; other site 502025008388 substrate-Mg2+ binding site; other site 502025008389 aspartate-rich region 1; other site 502025008390 aspartate-rich region 2; other site 502025008391 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 502025008392 active site lid residues [active] 502025008393 substrate binding pocket [chemical binding]; other site 502025008394 catalytic residues [active] 502025008395 substrate-Mg2+ binding site; other site 502025008396 aspartate-rich region 1; other site 502025008397 aspartate-rich region 2; other site 502025008398 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 502025008399 homodimer interface [polypeptide binding]; other site 502025008400 catalytic residues [active] 502025008401 NAD binding site [chemical binding]; other site 502025008402 substrate binding pocket [chemical binding]; other site 502025008403 flexible flap; other site 502025008404 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 502025008405 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 502025008406 mevalonate kinase; Region: mevalon_kin; TIGR00549 502025008407 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 502025008408 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 502025008409 homotetramer interface [polypeptide binding]; other site 502025008410 FMN binding site [chemical binding]; other site 502025008411 homodimer contacts [polypeptide binding]; other site 502025008412 putative active site [active] 502025008413 putative substrate binding site [chemical binding]; other site 502025008414 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025008415 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 502025008416 homodimer interface [polypeptide binding]; other site 502025008417 substrate-cofactor binding pocket; other site 502025008418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008419 catalytic residue [active] 502025008420 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 502025008421 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025008422 active site 502025008423 catalytic triad [active] 502025008424 dimer interface [polypeptide binding]; other site 502025008425 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025008426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025008427 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025008428 active site 502025008429 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 502025008430 Ion channel; Region: Ion_trans_2; cl11596 502025008431 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008432 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 502025008433 MutS domain I; Region: MutS_I; pfam01624 502025008434 MutS domain II; Region: MutS_II; pfam05188 502025008435 MutS family domain IV; Region: MutS_IV; pfam05190 502025008436 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 502025008437 Walker A/P-loop; other site 502025008438 ATP binding site [chemical binding]; other site 502025008439 Q-loop/lid; other site 502025008440 ABC transporter signature motif; other site 502025008441 Walker B; other site 502025008442 D-loop; other site 502025008443 H-loop/switch region; other site 502025008444 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 502025008445 CheB methylesterase; Region: CheB_methylest; pfam01339 502025008446 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025008447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025008448 PAS domain; Region: PAS_10; pfam13596 502025008449 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025008450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008451 PAS fold; Region: PAS_3; pfam08447 502025008452 putative active site [active] 502025008453 heme pocket [chemical binding]; other site 502025008454 PAS domain S-box; Region: sensory_box; TIGR00229 502025008455 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 502025008456 PAS domain S-box; Region: sensory_box; TIGR00229 502025008457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008458 dimer interface [polypeptide binding]; other site 502025008459 phosphorylation site [posttranslational modification] 502025008460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008461 ATP binding site [chemical binding]; other site 502025008462 Mg2+ binding site [ion binding]; other site 502025008463 G-X-G motif; other site 502025008464 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008466 active site 502025008467 phosphorylation site [posttranslational modification] 502025008468 intermolecular recognition site; other site 502025008469 dimerization interface [polypeptide binding]; other site 502025008470 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 502025008471 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008473 active site 502025008474 phosphorylation site [posttranslational modification] 502025008475 intermolecular recognition site; other site 502025008476 dimerization interface [polypeptide binding]; other site 502025008477 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025008478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025008479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025008480 active site 502025008481 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025008482 HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244 502025008483 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025008484 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 502025008485 RNA/DNA binding site [nucleotide binding]; other site 502025008486 RRM dimerization site [polypeptide binding]; other site 502025008487 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025008488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008489 Walker A/P-loop; other site 502025008490 ATP binding site [chemical binding]; other site 502025008491 Q-loop/lid; other site 502025008492 ABC transporter signature motif; other site 502025008493 Walker B; other site 502025008494 D-loop; other site 502025008495 H-loop/switch region; other site 502025008496 Permease; Region: Permease; cl00510 502025008497 Permease; Region: Permease; cl00510 502025008498 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025008499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008500 Walker A/P-loop; other site 502025008501 ATP binding site [chemical binding]; other site 502025008502 Q-loop/lid; other site 502025008503 ABC transporter signature motif; other site 502025008504 Walker B; other site 502025008505 D-loop; other site 502025008506 H-loop/switch region; other site 502025008507 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 502025008508 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 502025008509 tetramer interface [polypeptide binding]; other site 502025008510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008511 catalytic residue [active] 502025008512 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 502025008513 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 502025008514 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 502025008515 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 502025008516 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025008517 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025008518 signal recognition particle protein; Provisional; Region: PRK10867 502025008519 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 502025008520 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 502025008521 P loop; other site 502025008522 GTP binding site [chemical binding]; other site 502025008523 Signal peptide binding domain; Region: SRP_SPB; pfam02978 502025008524 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 502025008525 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 502025008526 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 502025008527 active site 502025008528 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 502025008529 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 502025008530 Lamin Tail Domain; Region: LTD; pfam00932 502025008531 CotH protein; Region: CotH; pfam08757 502025008532 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 502025008533 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 502025008534 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025008535 dimer interface [polypeptide binding]; other site 502025008536 active site 502025008537 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025008538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025008539 substrate binding site [chemical binding]; other site 502025008540 oxyanion hole (OAH) forming residues; other site 502025008541 trimer interface [polypeptide binding]; other site 502025008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025008543 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025008544 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 502025008545 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 502025008546 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 502025008547 GMP synthase; Reviewed; Region: guaA; PRK00074 502025008548 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 502025008549 AMP/PPi binding site [chemical binding]; other site 502025008550 candidate oxyanion hole; other site 502025008551 catalytic triad [active] 502025008552 potential glutamine specificity residues [chemical binding]; other site 502025008553 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 502025008554 ATP Binding subdomain [chemical binding]; other site 502025008555 Ligand Binding sites [chemical binding]; other site 502025008556 Dimerization subdomain; other site 502025008557 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025008558 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025008559 Walker A/P-loop; other site 502025008560 ATP binding site [chemical binding]; other site 502025008561 Q-loop/lid; other site 502025008562 ABC transporter signature motif; other site 502025008563 Walker B; other site 502025008564 D-loop; other site 502025008565 H-loop/switch region; other site 502025008566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025008567 FtsX-like permease family; Region: FtsX; cl15850 502025008568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008569 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008570 active site 502025008571 ATP binding site [chemical binding]; other site 502025008572 substrate binding site [chemical binding]; other site 502025008573 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008574 substrate binding site [chemical binding]; other site 502025008575 activation loop (A-loop); other site 502025008576 activation loop (A-loop); other site 502025008577 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008578 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008579 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 502025008580 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008581 phosphopeptide binding site; other site 502025008582 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 502025008583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025008584 Walker A motif; other site 502025008585 ATP binding site [chemical binding]; other site 502025008586 Walker B motif; other site 502025008587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025008588 TPR motif; other site 502025008589 binding surface 502025008590 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025008591 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 502025008592 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025008593 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025008594 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008595 phosphopeptide binding site; other site 502025008596 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025008597 active site 502025008598 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025008599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008601 active site 502025008602 ATP binding site [chemical binding]; other site 502025008603 substrate binding site [chemical binding]; other site 502025008604 activation loop (A-loop); other site 502025008605 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 502025008606 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 502025008607 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 502025008608 active site 502025008609 HIGH motif; other site 502025008610 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025008611 tRNA binding surface [nucleotide binding]; other site 502025008612 anticodon binding site; other site 502025008613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008614 active site 502025008615 ATP binding site [chemical binding]; other site 502025008616 substrate binding site [chemical binding]; other site 502025008617 activation loop (A-loop); other site 502025008618 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008620 active site 502025008621 phosphorylation site [posttranslational modification] 502025008622 intermolecular recognition site; other site 502025008623 dimerization interface [polypeptide binding]; other site 502025008624 Isochorismatase family; Region: Isochorismatase; pfam00857 502025008625 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 502025008626 catalytic triad [active] 502025008627 dimer interface [polypeptide binding]; other site 502025008628 conserved cis-peptide bond; other site 502025008629 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 502025008630 Lumazine binding domain; Region: Lum_binding; pfam00677 502025008631 Lumazine binding domain; Region: Lum_binding; pfam00677 502025008632 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 502025008633 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 502025008634 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 502025008635 active site 502025008636 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 502025008637 homopentamer interface [polypeptide binding]; other site 502025008638 active site 502025008639 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 502025008640 putative RNA binding site [nucleotide binding]; other site 502025008641 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 502025008642 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 502025008643 substrate-cofactor binding pocket; other site 502025008644 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025008645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025008646 catalytic residues [active] 502025008647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008648 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008649 active site 502025008650 ATP binding site [chemical binding]; other site 502025008651 substrate binding site [chemical binding]; other site 502025008652 activation loop (A-loop); other site 502025008653 Predicted ATPase [General function prediction only]; Region: COG3899 502025008654 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008656 binding surface 502025008657 TPR motif; other site 502025008658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008659 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008661 active site 502025008662 ATP binding site [chemical binding]; other site 502025008663 substrate binding site [chemical binding]; other site 502025008664 activation loop (A-loop); other site 502025008665 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 502025008666 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 502025008667 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 502025008668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025008669 catalytic core [active] 502025008670 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 502025008671 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 502025008672 tetramer interface [polypeptide binding]; other site 502025008673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008674 catalytic residue [active] 502025008675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008676 active site 502025008677 ATP binding site [chemical binding]; other site 502025008678 activation loop (A-loop); other site 502025008679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008680 active site 502025008681 phosphorylation site [posttranslational modification] 502025008682 intermolecular recognition site; other site 502025008683 dimerization interface [polypeptide binding]; other site 502025008684 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025008685 helix-hairpin-helix signature motif; other site 502025008686 substrate binding pocket [chemical binding]; other site 502025008687 active site 502025008688 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 502025008689 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025008690 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 502025008691 putative NAD(P) binding site [chemical binding]; other site 502025008692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025008693 classical (c) SDRs; Region: SDR_c; cd05233 502025008694 NAD(P) binding site [chemical binding]; other site 502025008695 active site 502025008696 Esterase/lipase [General function prediction only]; Region: COG1647 502025008697 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025008698 PilZ domain; Region: PilZ; cl01260 502025008699 PilZ domain; Region: PilZ; cl01260 502025008700 Protein of unknown function (DUF721); Region: DUF721; cl02324 502025008701 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025008702 active site 502025008703 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025008704 putative catalytic site [active] 502025008705 putative metal binding site [ion binding]; other site 502025008706 putative phosphate binding site [ion binding]; other site 502025008707 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025008708 catalytic core [active] 502025008709 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025008710 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008712 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008713 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008714 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008715 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008716 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008717 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008718 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025008719 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025008720 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025008721 AMP-binding enzyme; Region: AMP-binding; cl15778 502025008722 threonine dehydratase; Validated; Region: PRK08639 502025008723 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 502025008724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025008725 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025008726 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 502025008727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008728 dimer interface [polypeptide binding]; other site 502025008729 phosphorylation site [posttranslational modification] 502025008730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008731 ATP binding site [chemical binding]; other site 502025008732 Mg2+ binding site [ion binding]; other site 502025008733 G-X-G motif; other site 502025008734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008735 active site 502025008736 phosphorylation site [posttranslational modification] 502025008737 intermolecular recognition site; other site 502025008738 dimerization interface [polypeptide binding]; other site 502025008739 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 502025008740 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 502025008741 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025008742 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025008743 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025008744 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025008745 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 502025008746 FtsX-like permease family; Region: FtsX; cl15850 502025008747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025008748 FtsX-like permease family; Region: FtsX; cl15850 502025008749 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025008750 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025008751 Walker A/P-loop; other site 502025008752 ATP binding site [chemical binding]; other site 502025008753 Q-loop/lid; other site 502025008754 ABC transporter signature motif; other site 502025008755 Walker B; other site 502025008756 D-loop; other site 502025008757 H-loop/switch region; other site 502025008758 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025008759 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 502025008760 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 502025008761 putative catalytic residue [active] 502025008762 OsmC-like protein; Region: OsmC; cl00767 502025008763 Protein of unknown function (DUF507); Region: DUF507; cl01112 502025008764 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 502025008765 active site 502025008766 8-oxo-dGMP binding site [chemical binding]; other site 502025008767 nudix motif; other site 502025008768 metal binding site [ion binding]; metal-binding site 502025008769 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 502025008770 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025008771 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025008772 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 502025008773 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 502025008774 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 502025008775 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025008776 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 502025008777 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 502025008778 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 502025008779 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 502025008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025008781 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008782 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008783 active site 502025008784 ATP binding site [chemical binding]; other site 502025008785 substrate binding site [chemical binding]; other site 502025008786 activation loop (A-loop); other site 502025008787 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 502025008788 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 502025008789 Ligand Binding Site [chemical binding]; other site 502025008790 ribonuclease III; Reviewed; Region: rnc; PRK00102 502025008791 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 502025008792 dimerization interface [polypeptide binding]; other site 502025008793 active site 502025008794 metal binding site [ion binding]; metal-binding site 502025008795 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 502025008796 dsRNA binding site [nucleotide binding]; other site 502025008797 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 502025008798 Ligand Binding Site [chemical binding]; other site 502025008799 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 502025008800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008801 Walker A motif; other site 502025008802 ATP binding site [chemical binding]; other site 502025008803 Walker B motif; other site 502025008804 arginine finger; other site 502025008805 Peptidase family M41; Region: Peptidase_M41; pfam01434 502025008806 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 502025008807 dihydropteroate synthase; Region: DHPS; TIGR01496 502025008808 substrate binding pocket [chemical binding]; other site 502025008809 dimer interface [polypeptide binding]; other site 502025008810 inhibitor binding site; inhibition site 502025008811 Uncharacterized conserved protein [Function unknown]; Region: COG1624 502025008812 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 502025008813 YbbR-like protein; Region: YbbR; pfam07949 502025008814 YbbR-like protein; Region: YbbR; pfam07949 502025008815 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025008816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025008817 Helix-turn-helix domains; Region: HTH; cl00088 502025008818 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 502025008819 active site 502025008820 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 502025008821 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 502025008822 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025008823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025008824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008825 binding surface 502025008826 TPR motif; other site 502025008827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008828 TPR motif; other site 502025008829 binding surface 502025008830 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 502025008831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025008832 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 502025008833 Recombination protein O N terminal; Region: RecO_N; cl15812 502025008834 Recombination protein O C terminal; Region: RecO_C; pfam02565 502025008835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025008836 TPR motif; other site 502025008837 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008838 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025008839 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025008840 Ca2+ binding site [ion binding]; other site 502025008841 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025008842 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025008843 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025008844 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025008845 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025008846 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 502025008847 Outer membrane efflux protein; Region: OEP; pfam02321 502025008848 Outer membrane efflux protein; Region: OEP; pfam02321 502025008849 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008850 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008851 active site 502025008852 ATP binding site [chemical binding]; other site 502025008853 substrate binding site [chemical binding]; other site 502025008854 activation loop (A-loop); other site 502025008855 cyclase homology domain; Region: CHD; cd07302 502025008856 dimer interface [polypeptide binding]; other site 502025008857 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008858 active site 502025008859 ATP binding site [chemical binding]; other site 502025008860 substrate binding site [chemical binding]; other site 502025008861 activation loop (A-loop); other site 502025008862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008865 TPR motif; other site 502025008866 binding surface 502025008867 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008868 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008871 Penicillin amidase; Region: Penicil_amidase; pfam01804 502025008872 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025008873 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 502025008874 active site 502025008875 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025008876 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025008877 AMP-binding enzyme; Region: AMP-binding; cl15778 502025008878 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025008879 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 502025008880 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 502025008881 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 502025008882 hinge; other site 502025008883 active site 502025008884 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 502025008885 anthranilate synthase component I; Provisional; Region: PRK13565 502025008886 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 502025008887 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025008888 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 502025008889 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 502025008890 glutamine binding [chemical binding]; other site 502025008891 catalytic triad [active] 502025008892 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025008893 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 502025008894 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025008895 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 502025008896 active site 502025008897 ribulose/triose binding site [chemical binding]; other site 502025008898 phosphate binding site [ion binding]; other site 502025008899 substrate (anthranilate) binding pocket [chemical binding]; other site 502025008900 product (indole) binding pocket [chemical binding]; other site 502025008901 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 502025008902 active site 502025008903 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 502025008904 dimer interface [polypeptide binding]; other site 502025008905 Citrate synthase; Region: Citrate_synt; pfam00285 502025008906 active site 502025008907 citrylCoA binding site [chemical binding]; other site 502025008908 NADH binding [chemical binding]; other site 502025008909 cationic pore residues; other site 502025008910 oxalacetate/citrate binding site [chemical binding]; other site 502025008911 coenzyme A binding site [chemical binding]; other site 502025008912 catalytic triad [active] 502025008913 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 502025008914 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 502025008915 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025008916 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025008917 Phosphotransferase enzyme family; Region: APH; pfam01636 502025008918 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008919 active site 502025008920 substrate binding site [chemical binding]; other site 502025008921 ATP binding site [chemical binding]; other site 502025008922 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008923 substrate binding site [chemical binding]; other site 502025008924 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025008925 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 502025008926 active site 502025008927 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 502025008928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025008929 active site 502025008930 motif I; other site 502025008931 motif II; other site 502025008932 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 502025008933 active site 502025008934 catalytic residues [active] 502025008935 metal binding site [ion binding]; metal-binding site 502025008936 enoyl-CoA hydratase; Provisional; Region: PRK07657 502025008937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025008938 substrate binding site [chemical binding]; other site 502025008939 oxyanion hole (OAH) forming residues; other site 502025008940 trimer interface [polypeptide binding]; other site 502025008941 Bacitracin resistance protein BacA; Region: BacA; cl00858 502025008942 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008943 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008944 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008945 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008946 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008947 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025008948 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025008949 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 502025008950 putative NAD(P) binding site [chemical binding]; other site 502025008951 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 502025008952 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 502025008953 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025008954 active site 502025008955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025008956 S-adenosylmethionine binding site [chemical binding]; other site 502025008957 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 502025008958 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 502025008959 active site 502025008960 substrate binding site [chemical binding]; other site 502025008961 metal binding site [ion binding]; metal-binding site 502025008962 putative carbohydrate kinase; Provisional; Region: PRK10565 502025008963 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 502025008964 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 502025008965 putative substrate binding site [chemical binding]; other site 502025008966 putative ATP binding site [chemical binding]; other site 502025008967 RNA polymerase subunit; Provisional; Region: PHA02998 502025008968 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 502025008969 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025008970 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025008971 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 502025008972 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 502025008973 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008974 phosphopeptide binding site; other site 502025008975 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025008976 metal ion-dependent adhesion site (MIDAS); other site 502025008977 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008978 phosphopeptide binding site; other site 502025008979 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008980 phosphopeptide binding site; other site 502025008981 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008982 phosphopeptide binding site; other site 502025008983 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025008984 Ycf46; Provisional; Region: ycf46; CHL00195 502025008985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008986 Walker A motif; other site 502025008987 ATP binding site [chemical binding]; other site 502025008988 Walker B motif; other site 502025008989 arginine finger; other site 502025008990 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 502025008991 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 502025008992 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025008993 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 502025008994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008996 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025008998 binding surface 502025008999 TPR motif; other site 502025009000 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025009001 Protein phosphatase 2C; Region: PP2C; pfam00481 502025009002 active site 502025009003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009004 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009005 active site 502025009006 ATP binding site [chemical binding]; other site 502025009007 substrate binding site [chemical binding]; other site 502025009008 activation loop (A-loop); other site 502025009009 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009010 Putative Catalytic site; other site 502025009011 DXD motif; other site 502025009012 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 502025009013 hydrophobic ligand binding site; other site 502025009014 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 502025009015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025009016 motif II; other site 502025009017 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 502025009018 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009019 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009020 active site 502025009021 ATP binding site [chemical binding]; other site 502025009022 substrate binding site [chemical binding]; other site 502025009023 activation loop (A-loop); other site 502025009024 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025009025 catalytic triad [active] 502025009026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009027 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009028 active site 502025009029 ATP binding site [chemical binding]; other site 502025009030 substrate binding site [chemical binding]; other site 502025009031 activation loop (A-loop); other site 502025009032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009033 Predicted ATPase [General function prediction only]; Region: COG3899 502025009034 NAD synthetase; Reviewed; Region: nadE; PRK02628 502025009035 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 502025009036 active site 502025009037 catalytic triad [active] 502025009038 multimer interface [polypeptide binding]; other site 502025009039 protein interface 1 [polypeptide binding]; other site 502025009040 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 502025009041 homodimer interface [polypeptide binding]; other site 502025009042 NAD binding pocket [chemical binding]; other site 502025009043 ATP binding pocket [chemical binding]; other site 502025009044 Mg binding site [ion binding]; other site 502025009045 active-site loop [active] 502025009046 DoxX; Region: DoxX; cl00976 502025009047 seryl-tRNA synthetase; Provisional; Region: PRK05431 502025009048 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 502025009049 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 502025009050 motif 1; other site 502025009051 dimer interface [polypeptide binding]; other site 502025009052 active site 502025009053 motif 2; other site 502025009054 motif 3; other site 502025009055 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 502025009056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009057 Walker A/P-loop; other site 502025009058 ATP binding site [chemical binding]; other site 502025009059 Q-loop/lid; other site 502025009060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009061 ABC transporter signature motif; other site 502025009062 Walker B; other site 502025009063 D-loop; other site 502025009064 H-loop/switch region; other site 502025009065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009066 Walker A/P-loop; other site 502025009067 ATP binding site [chemical binding]; other site 502025009068 Q-loop/lid; other site 502025009069 ABC transporter signature motif; other site 502025009070 Walker B; other site 502025009071 D-loop; other site 502025009072 H-loop/switch region; other site 502025009073 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 502025009074 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 502025009075 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 502025009076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009077 ABC transporter signature motif; other site 502025009078 Walker B; other site 502025009079 D-loop; other site 502025009080 H-loop/switch region; other site 502025009081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009082 Walker A/P-loop; other site 502025009083 ATP binding site [chemical binding]; other site 502025009084 Q-loop/lid; other site 502025009085 ABC transporter signature motif; other site 502025009086 Walker B; other site 502025009087 D-loop; other site 502025009088 H-loop/switch region; other site 502025009089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025009090 GAF domain; Region: GAF_2; pfam13185 502025009091 GAF domain; Region: GAF; cl15785 502025009092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009093 Walker A motif; other site 502025009094 ATP binding site [chemical binding]; other site 502025009095 Walker B motif; other site 502025009096 arginine finger; other site 502025009097 Helix-turn-helix domains; Region: HTH; cl00088 502025009098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 502025009099 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 502025009100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009102 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 502025009103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025009104 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 502025009105 GTP1/OBG; Region: GTP1_OBG; pfam01018 502025009106 Obg GTPase; Region: Obg; cd01898 502025009107 G1 box; other site 502025009108 GTP/Mg2+ binding site [chemical binding]; other site 502025009109 Switch I region; other site 502025009110 G2 box; other site 502025009111 G3 box; other site 502025009112 Switch II region; other site 502025009113 G4 box; other site 502025009114 G5 box; other site 502025009115 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025009116 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025009117 Walker A/P-loop; other site 502025009118 ATP binding site [chemical binding]; other site 502025009119 Q-loop/lid; other site 502025009120 ABC transporter signature motif; other site 502025009121 Walker B; other site 502025009122 D-loop; other site 502025009123 H-loop/switch region; other site 502025009124 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025009125 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025009126 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025009127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009128 binding surface 502025009129 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 502025009130 TPR motif; other site 502025009131 Rhomboid family; Region: Rhomboid; cl11446 502025009132 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025009133 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 502025009134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009135 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 502025009136 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025009137 dimer interface [polypeptide binding]; other site 502025009138 [2Fe-2S] cluster binding site [ion binding]; other site 502025009139 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 502025009140 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025009141 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025009142 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025009143 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025009144 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025009145 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025009146 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 502025009147 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 502025009149 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009150 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009151 phosphopeptide binding site; other site 502025009152 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025009153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009154 Walker A motif; other site 502025009155 ATP binding site [chemical binding]; other site 502025009156 Walker B motif; other site 502025009157 arginine finger; other site 502025009158 Helix-turn-helix domains; Region: HTH; cl00088 502025009159 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009160 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009161 active site 502025009162 ATP binding site [chemical binding]; other site 502025009163 substrate binding site [chemical binding]; other site 502025009164 activation loop (A-loop); other site 502025009165 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 502025009167 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 502025009168 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025009169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025009170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025009171 DNA binding residues [nucleotide binding] 502025009172 HEAT repeats; Region: HEAT_2; pfam13646 502025009173 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025009174 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 502025009175 HEAT repeats; Region: HEAT_2; pfam13646 502025009176 HEAT repeats; Region: HEAT_2; pfam13646 502025009177 TPR repeat; Region: TPR_11; pfam13414 502025009178 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 502025009179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025009180 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009181 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009182 active site 502025009183 ATP binding site [chemical binding]; other site 502025009184 substrate binding site [chemical binding]; other site 502025009185 activation loop (A-loop); other site 502025009186 VanW like protein; Region: VanW; pfam04294 502025009187 G5 domain; Region: G5; pfam07501 502025009188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 502025009189 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009190 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025009191 Sulfatase; Region: Sulfatase; cl10460 502025009192 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025009193 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009194 Ligand binding site; other site 502025009195 Putative Catalytic site; other site 502025009196 DXD motif; other site 502025009197 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 502025009198 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 502025009199 Uncharacterized conserved protein [Function unknown]; Region: COG1912 502025009200 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 502025009201 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 502025009202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025009203 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 502025009204 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 502025009205 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 502025009206 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 502025009207 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025009208 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025009209 Surface antigen; Region: Bac_surface_Ag; cl03097 502025009210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 502025009211 Family of unknown function (DUF490); Region: DUF490; pfam04357 502025009212 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025009213 protein binding site [polypeptide binding]; other site 502025009214 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 502025009215 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 502025009216 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 502025009217 P loop; other site 502025009218 GTP binding site [chemical binding]; other site 502025009219 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009220 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009221 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 502025009222 Walker A/P-loop; other site 502025009223 ATP binding site [chemical binding]; other site 502025009224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009225 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025009226 Q-loop/lid; other site 502025009227 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 502025009228 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 502025009229 Q-loop/lid; other site 502025009230 ABC transporter signature motif; other site 502025009231 Walker B; other site 502025009232 D-loop; other site 502025009233 H-loop/switch region; other site 502025009234 lipoyl synthase; Provisional; Region: PRK05481 502025009235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025009236 FeS/SAM binding site; other site 502025009237 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 502025009238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025009239 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025009240 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 502025009241 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025009242 E3 interaction surface; other site 502025009243 lipoyl attachment site [posttranslational modification]; other site 502025009244 e3 binding domain; Region: E3_binding; pfam02817 502025009245 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 502025009246 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 502025009247 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 502025009248 alpha subunit interface [polypeptide binding]; other site 502025009249 TPP binding site [chemical binding]; other site 502025009250 heterodimer interface [polypeptide binding]; other site 502025009251 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025009252 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 502025009253 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 502025009254 tetramer interface [polypeptide binding]; other site 502025009255 TPP-binding site [chemical binding]; other site 502025009256 heterodimer interface [polypeptide binding]; other site 502025009257 phosphorylation loop region [posttranslational modification] 502025009258 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 502025009259 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025009260 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025009261 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025009262 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 502025009263 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 502025009264 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 502025009265 active site 502025009266 (T/H)XGH motif; other site 502025009267 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 502025009268 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025009269 dimer interface [polypeptide binding]; other site 502025009270 [2Fe-2S] cluster binding site [ion binding]; other site 502025009271 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025009272 ligand binding site [chemical binding]; other site 502025009273 flexible hinge region; other site 502025009274 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025009275 ligand binding site [chemical binding]; other site 502025009276 flexible hinge region; other site 502025009277 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025009278 GAF domain; Region: GAF; cl15785 502025009279 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025009280 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 502025009281 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025009282 catalytic residue [active] 502025009283 GTPase Era; Reviewed; Region: era; PRK00089 502025009284 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 502025009285 G1 box; other site 502025009286 GTP/Mg2+ binding site [chemical binding]; other site 502025009287 Switch I region; other site 502025009288 G2 box; other site 502025009289 Switch II region; other site 502025009290 G3 box; other site 502025009291 G4 box; other site 502025009292 G5 box; other site 502025009293 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 502025009294 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 502025009295 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 502025009296 G1 box; other site 502025009297 GTP/Mg2+ binding site [chemical binding]; other site 502025009298 Switch I region; other site 502025009299 G2 box; other site 502025009300 Switch II region; other site 502025009301 G3 box; other site 502025009302 G4 box; other site 502025009303 G5 box; other site 502025009304 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 502025009305 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 502025009306 G1 box; other site 502025009307 GTP/Mg2+ binding site [chemical binding]; other site 502025009308 Switch I region; other site 502025009309 G2 box; other site 502025009310 G3 box; other site 502025009311 Switch II region; other site 502025009312 G4 box; other site 502025009313 G5 box; other site 502025009314 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025009315 Trp docking motif [polypeptide binding]; other site 502025009316 active site 502025009317 PQQ-like domain; Region: PQQ_2; pfam13360 502025009318 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 502025009319 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 502025009320 putative active site; other site 502025009321 putative metal binding residues [ion binding]; other site 502025009322 putative triphosphate binding site [ion binding]; other site 502025009323 signature motif; other site 502025009324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 502025009325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025009326 dimerization interface [polypeptide binding]; other site 502025009327 putative Zn2+ binding site [ion binding]; other site 502025009328 putative DNA binding site [nucleotide binding]; other site 502025009329 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 502025009330 active site 502025009331 catalytic triad [active] 502025009332 dimer interface [polypeptide binding]; other site 502025009333 Response regulator receiver domain; Region: Response_reg; pfam00072 502025009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009335 active site 502025009336 phosphorylation site [posttranslational modification] 502025009337 intermolecular recognition site; other site 502025009338 dimerization interface [polypeptide binding]; other site 502025009339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025009340 active site 502025009341 Survival protein SurE; Region: SurE; cl00448 502025009342 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 502025009343 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025009344 DNA binding residues [nucleotide binding] 502025009345 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025009346 IHF dimer interface [polypeptide binding]; other site 502025009347 IHF - DNA interface [nucleotide binding]; other site 502025009348 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 502025009349 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 502025009350 putative tRNA-binding site [nucleotide binding]; other site 502025009351 B3/4 domain; Region: B3_4; cl11458 502025009352 tRNA synthetase B5 domain; Region: B5; cl08394 502025009353 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 502025009354 dimer interface [polypeptide binding]; other site 502025009355 motif 1; other site 502025009356 motif 3; other site 502025009357 motif 2; other site 502025009358 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 502025009359 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 502025009360 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 502025009361 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 502025009362 dimer interface [polypeptide binding]; other site 502025009363 motif 1; other site 502025009364 active site 502025009365 motif 2; other site 502025009366 motif 3; other site 502025009367 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 502025009368 23S rRNA binding site [nucleotide binding]; other site 502025009369 L21 binding site [polypeptide binding]; other site 502025009370 L13 binding site [polypeptide binding]; other site 502025009371 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 502025009372 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009373 Protein kinase domain; Region: Pkinase; pfam00069 502025009374 active site 502025009375 ATP binding site [chemical binding]; other site 502025009376 substrate binding site [chemical binding]; other site 502025009377 activation loop (A-loop); other site 502025009378 transcriptional regulator MalT; Provisional; Region: PRK04841 502025009379 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025009380 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 502025009381 GAF domain; Region: GAF; cl15785 502025009382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009383 Walker A motif; other site 502025009384 ATP binding site [chemical binding]; other site 502025009385 Walker B motif; other site 502025009386 arginine finger; other site 502025009387 Helix-turn-helix domains; Region: HTH; cl00088 502025009388 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009389 helicase 45; Provisional; Region: PTZ00424 502025009390 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 502025009391 ATP binding site [chemical binding]; other site 502025009392 Mg++ binding site [ion binding]; other site 502025009393 motif III; other site 502025009394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025009395 nucleotide binding region [chemical binding]; other site 502025009396 ATP-binding site [chemical binding]; other site 502025009397 DbpA RNA binding domain; Region: DbpA; pfam03880 502025009398 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 502025009399 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 502025009400 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025009401 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009402 Ligand binding site; other site 502025009403 Putative Catalytic site; other site 502025009404 DXD motif; other site 502025009405 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 502025009406 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 502025009407 dimerization interface [polypeptide binding]; other site 502025009408 putative ATP binding site [chemical binding]; other site 502025009409 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 502025009410 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 502025009411 active site 502025009412 substrate binding site [chemical binding]; other site 502025009413 cosubstrate binding site; other site 502025009414 catalytic site [active] 502025009415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025009416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009417 active site 502025009418 ATP binding site [chemical binding]; other site 502025009419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009420 substrate binding site [chemical binding]; other site 502025009421 activation loop (A-loop); other site 502025009422 Predicted ATPase [General function prediction only]; Region: COG3899 502025009423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009425 binding surface 502025009426 TPR motif; other site 502025009427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009428 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009429 active site 502025009430 ATP binding site [chemical binding]; other site 502025009431 substrate binding site [chemical binding]; other site 502025009432 activation loop (A-loop); other site 502025009433 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 502025009434 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025009435 active site 502025009436 metal binding site [ion binding]; metal-binding site 502025009437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025009438 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025009439 Cysteine-rich domain; Region: CCG; pfam02754 502025009440 Cysteine-rich domain; Region: CCG; pfam02754 502025009441 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 502025009442 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 502025009443 Catalytic site [active] 502025009444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 502025009445 GTP-binding protein LepA; Provisional; Region: PRK05433 502025009446 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 502025009447 G1 box; other site 502025009448 putative GEF interaction site [polypeptide binding]; other site 502025009449 GTP/Mg2+ binding site [chemical binding]; other site 502025009450 Switch I region; other site 502025009451 G2 box; other site 502025009452 G3 box; other site 502025009453 Switch II region; other site 502025009454 G4 box; other site 502025009455 G5 box; other site 502025009456 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 502025009457 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 502025009458 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 502025009459 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 502025009460 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 502025009461 dimer interface [polypeptide binding]; other site 502025009462 active site 502025009463 glycine-pyridoxal phosphate binding site [chemical binding]; other site 502025009464 folate binding site [chemical binding]; other site 502025009465 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 502025009466 ArgK protein; Region: ArgK; pfam03308 502025009467 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 502025009468 Walker A; other site 502025009469 Cupin domain; Region: Cupin_2; cl09118 502025009470 Cupin domain; Region: Cupin_2; cl09118 502025009471 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 502025009472 B12 binding site [chemical binding]; other site 502025009473 cobalt ligand [ion binding]; other site 502025009474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025009475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025009476 active site 502025009477 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025009478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025009479 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 502025009480 FAD binding site [chemical binding]; other site 502025009481 homotetramer interface [polypeptide binding]; other site 502025009482 substrate binding pocket [chemical binding]; other site 502025009483 catalytic base [active] 502025009484 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 502025009485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025009486 substrate binding site [chemical binding]; other site 502025009487 oxyanion hole (OAH) forming residues; other site 502025009488 trimer interface [polypeptide binding]; other site 502025009489 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 502025009490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025009491 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025009492 putative acyltransferase; Provisional; Region: PRK05790 502025009493 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025009494 dimer interface [polypeptide binding]; other site 502025009495 active site 502025009496 MASE1; Region: MASE1; pfam05231 502025009497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025009498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025009499 dimer interface [polypeptide binding]; other site 502025009500 phosphorylation site [posttranslational modification] 502025009501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025009502 ATP binding site [chemical binding]; other site 502025009503 Mg2+ binding site [ion binding]; other site 502025009504 G-X-G motif; other site 502025009505 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 502025009506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025009507 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 502025009508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025009509 FeS/SAM binding site; other site 502025009510 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 502025009511 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 502025009512 catalytic triad [active] 502025009513 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 502025009514 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025009515 putative active site [active] 502025009516 putative active site [active] 502025009517 catalytic site [active] 502025009518 catalytic site [active] 502025009519 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 502025009520 phospholipase D epsilon; Region: PLN02352 502025009521 putative active site [active] 502025009522 catalytic site [active] 502025009523 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 502025009524 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 502025009525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025009526 FeS/SAM binding site; other site 502025009527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009528 binding surface 502025009529 TPR motif; other site 502025009530 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009531 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009532 active site 502025009533 ATP binding site [chemical binding]; other site 502025009534 substrate binding site [chemical binding]; other site 502025009535 activation loop (A-loop); other site 502025009536 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025009538 NAD(P) binding site [chemical binding]; other site 502025009539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025009540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 502025009541 SEC-C motif; Region: SEC-C; pfam02810 502025009542 Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; Region: H2A; cl00074 502025009543 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025009544 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 502025009545 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025009546 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025009547 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025009548 active site 502025009549 metal binding site [ion binding]; metal-binding site 502025009550 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 502025009551 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 502025009552 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 502025009553 Right handed beta helix region; Region: Beta_helix; pfam13229 502025009554 Right handed beta helix region; Region: Beta_helix; pfam13229 502025009555 Right handed beta helix region; Region: Beta_helix; pfam13229 502025009556 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 502025009557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025009558 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025009559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009560 Walker A/P-loop; other site 502025009561 ATP binding site [chemical binding]; other site 502025009562 Q-loop/lid; other site 502025009563 ABC transporter signature motif; other site 502025009564 Walker B; other site 502025009565 D-loop; other site 502025009566 H-loop/switch region; other site 502025009567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025009568 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025009569 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 502025009570 Walker A/P-loop; other site 502025009571 ATP binding site [chemical binding]; other site 502025009572 Q-loop/lid; other site 502025009573 ABC transporter signature motif; other site 502025009574 Walker B; other site 502025009575 D-loop; other site 502025009576 H-loop/switch region; other site 502025009577 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025009578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025009579 putative active site [active] 502025009580 heme pocket [chemical binding]; other site 502025009581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025009582 dimer interface [polypeptide binding]; other site 502025009583 phosphorylation site [posttranslational modification] 502025009584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025009585 ATP binding site [chemical binding]; other site 502025009586 Mg2+ binding site [ion binding]; other site 502025009587 G-X-G motif; other site 502025009588 Response regulator receiver domain; Region: Response_reg; pfam00072 502025009589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025009590 active site 502025009591 phosphorylation site [posttranslational modification] 502025009592 intermolecular recognition site; other site 502025009593 dimerization interface [polypeptide binding]; other site 502025009594 Response regulator receiver domain; Region: Response_reg; pfam00072 502025009595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009596 active site 502025009597 phosphorylation site [posttranslational modification] 502025009598 intermolecular recognition site; other site 502025009599 dimerization interface [polypeptide binding]; other site 502025009600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025009601 metal binding site [ion binding]; metal-binding site 502025009602 active site 502025009603 I-site; other site 502025009604 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025009605 putative active site [active] 502025009606 putative metal binding site [ion binding]; other site 502025009607 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025009608 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025009609 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025009610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009611 binding surface 502025009612 TPR motif; other site 502025009613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009614 TPR motif; other site 502025009615 binding surface 502025009616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009617 TPR motif; other site 502025009618 binding surface 502025009619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009620 TPR motif; other site 502025009621 binding surface 502025009622 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 502025009623 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025009624 catalytic core [active] 502025009625 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025009626 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009627 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009628 active site 502025009629 ATP binding site [chemical binding]; other site 502025009630 substrate binding site [chemical binding]; other site 502025009631 activation loop (A-loop); other site 502025009632 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009634 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025009635 structural tetrad; other site 502025009636 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025009637 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025009638 structural tetrad; other site 502025009639 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025009640 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009641 phosphopeptide binding site; other site 502025009642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009643 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009644 active site 502025009645 ATP binding site [chemical binding]; other site 502025009646 substrate binding site [chemical binding]; other site 502025009647 activation loop (A-loop); other site 502025009648 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009650 TPR repeat; Region: TPR_11; pfam13414 502025009651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009652 binding surface 502025009653 TPR motif; other site 502025009654 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025009655 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025009656 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025009657 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025009658 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025009659 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025009660 Protein phosphatase 2C; Region: PP2C; pfam00481 502025009661 active site 502025009662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025009663 ligand binding site [chemical binding]; other site 502025009664 flexible hinge region; other site 502025009665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025009666 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025009667 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025009668 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025009669 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025009670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025009671 Uncharacterized conserved protein [Function unknown]; Region: COG3461 502025009672 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 502025009673 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 502025009674 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 502025009675 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025009676 Ligand Binding Site [chemical binding]; other site 502025009677 Molecular Tunnel; other site 502025009678 colanic acid exporter; Provisional; Region: PRK10459 502025009679 MatE; Region: MatE; cl10513 502025009680 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 502025009681 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 502025009682 dimerization interface [polypeptide binding]; other site 502025009683 ATP binding site [chemical binding]; other site 502025009684 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 502025009685 dimerization interface [polypeptide binding]; other site 502025009686 ATP binding site [chemical binding]; other site 502025009687 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 502025009688 putative active site [active] 502025009689 catalytic triad [active] 502025009690 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 502025009691 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 502025009692 active site 502025009693 ATP binding site [chemical binding]; other site 502025009694 substrate binding site [chemical binding]; other site 502025009695 adenylosuccinate lyase; Provisional; Region: PRK07492 502025009696 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 502025009697 tetramer interface [polypeptide binding]; other site 502025009698 active site 502025009699 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 502025009700 trimer interface [polypeptide binding]; other site 502025009701 active site 502025009702 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 502025009703 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 502025009704 RNase E interface [polypeptide binding]; other site 502025009705 trimer interface [polypeptide binding]; other site 502025009706 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 502025009707 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 502025009708 RNase E interface [polypeptide binding]; other site 502025009709 trimer interface [polypeptide binding]; other site 502025009710 active site 502025009711 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 502025009712 putative nucleic acid binding region [nucleotide binding]; other site 502025009713 G-X-X-G motif; other site 502025009714 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 502025009715 RNA binding site [nucleotide binding]; other site 502025009716 domain interface; other site 502025009717 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 502025009718 16S/18S rRNA binding site [nucleotide binding]; other site 502025009719 S13e-L30e interaction site [polypeptide binding]; other site 502025009720 25S rRNA binding site [nucleotide binding]; other site 502025009721 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 502025009722 RNA binding site [nucleotide binding]; other site 502025009723 active site 502025009724 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 502025009725 Ribosome-binding factor A; Region: RBFA; cl00542 502025009726 Protein of unknown function (DUF503); Region: DUF503; cl00669 502025009727 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025009728 translation initiation factor IF-2; Region: IF-2; TIGR00487 502025009729 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025009730 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 502025009731 G1 box; other site 502025009732 putative GEF interaction site [polypeptide binding]; other site 502025009733 GTP/Mg2+ binding site [chemical binding]; other site 502025009734 Switch I region; other site 502025009735 G2 box; other site 502025009736 G3 box; other site 502025009737 Switch II region; other site 502025009738 G4 box; other site 502025009739 G5 box; other site 502025009740 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 502025009741 Translation-initiation factor 2; Region: IF-2; pfam11987 502025009742 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 502025009743 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 502025009744 putative RNA binding cleft [nucleotide binding]; other site 502025009745 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 502025009746 NusA N-terminal domain; Region: NusA_N; pfam08529 502025009747 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 502025009748 RNA binding site [nucleotide binding]; other site 502025009749 homodimer interface [polypeptide binding]; other site 502025009750 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 502025009751 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 502025009752 G-X-X-G motif; other site 502025009753 ribosome maturation protein RimP; Reviewed; Region: PRK00092 502025009754 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 502025009755 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 502025009756 Sm1 motif; other site 502025009757 D1 - D2 interaction site; other site 502025009758 D3 - B interaction site; other site 502025009759 Hfq - Hfq interaction site; other site 502025009760 RNA binding pocket [nucleotide binding]; other site 502025009761 Sm2 motif; other site 502025009762 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025009763 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 502025009764 putative active site [active] 502025009765 catalytic triad [active] 502025009766 dimer interface [polypeptide binding]; other site 502025009767 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 502025009768 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 502025009769 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 502025009770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009771 Walker A/P-loop; other site 502025009772 ATP binding site [chemical binding]; other site 502025009773 AAA domain; Region: AAA_21; pfam13304 502025009774 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 502025009775 active site 502025009776 dimer interface [polypeptide binding]; other site 502025009777 prolyl-tRNA synthetase; Provisional; Region: PRK09194 502025009778 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 502025009779 dimer interface [polypeptide binding]; other site 502025009780 motif 1; other site 502025009781 active site 502025009782 motif 2; other site 502025009783 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 502025009784 putative deacylase active site [active] 502025009785 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 502025009786 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 502025009787 anticodon binding site; other site 502025009788 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 502025009789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009790 binding surface 502025009791 TPR motif; other site 502025009792 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 502025009793 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 502025009794 active site 502025009795 Imelysin; Region: Peptidase_M75; cl09159 502025009796 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025009797 Imelysin; Region: Peptidase_M75; cl09159 502025009798 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025009799 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025009800 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025009801 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 502025009802 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025009803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009805 active site 502025009806 ATP binding site [chemical binding]; other site 502025009807 substrate binding site [chemical binding]; other site 502025009808 activation loop (A-loop); other site 502025009809 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025009810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025009812 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009813 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009814 active site 502025009815 ATP binding site [chemical binding]; other site 502025009816 substrate binding site [chemical binding]; other site 502025009817 activation loop (A-loop); other site 502025009818 transketolase; Reviewed; Region: PRK05899 502025009819 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 502025009820 TPP-binding site [chemical binding]; other site 502025009821 dimer interface [polypeptide binding]; other site 502025009822 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 502025009823 PYR/PP interface [polypeptide binding]; other site 502025009824 dimer interface [polypeptide binding]; other site 502025009825 TPP binding site [chemical binding]; other site 502025009826 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025009827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009828 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009829 active site 502025009830 ATP binding site [chemical binding]; other site 502025009831 substrate binding site [chemical binding]; other site 502025009832 activation loop (A-loop); other site 502025009833 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025009834 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009835 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009836 active site 502025009837 ATP binding site [chemical binding]; other site 502025009838 substrate binding site [chemical binding]; other site 502025009839 activation loop (A-loop); other site 502025009840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009842 active site 502025009843 ATP binding site [chemical binding]; other site 502025009844 substrate binding site [chemical binding]; other site 502025009845 activation loop (A-loop); other site 502025009846 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025009847 FIST N domain; Region: FIST; cl10701 502025009848 FIST C domain; Region: FIST_C; pfam10442 502025009849 FIST N domain; Region: FIST; cl10701 502025009850 FIST N domain; Region: FIST; cl10701 502025009851 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025009852 FIST C domain; Region: FIST_C; pfam10442 502025009853 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025009854 protein binding site [polypeptide binding]; other site 502025009855 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025009856 Protein of unknown function, DUF482; Region: DUF482; pfam04339 502025009857 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 502025009858 putative GSH binding site [chemical binding]; other site 502025009859 catalytic residues [active] 502025009860 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 502025009861 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025009862 active site residue [active] 502025009863 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025009864 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 502025009865 AMP-binding enzyme; Region: AMP-binding; cl15778 502025009866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009867 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025009868 IHF dimer interface [polypeptide binding]; other site 502025009869 IHF - DNA interface [nucleotide binding]; other site 502025009870 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 502025009871 Qi binding site; other site 502025009872 intrachain domain interface; other site 502025009873 interchain domain interface [polypeptide binding]; other site 502025009874 heme bH binding site [chemical binding]; other site 502025009875 heme bL binding site [chemical binding]; other site 502025009876 Qo binding site; other site 502025009877 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 502025009878 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 502025009879 Cytochrome c; Region: Cytochrom_C; cl11414 502025009880 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 502025009881 iron-sulfur cluster [ion binding]; other site 502025009882 [2Fe-2S] cluster binding site [ion binding]; other site 502025009883 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 502025009884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025009885 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025009886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009887 binding surface 502025009888 TPR motif; other site 502025009889 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025009890 carbonate dehydratase; Region: PLN00416 502025009891 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 502025009892 active sites [active] 502025009893 tetramer interface [polypeptide binding]; other site 502025009894 imidazolonepropionase; Validated; Region: PRK09356 502025009895 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 502025009896 active site 502025009897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009898 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025009899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025009900 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 502025009901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009902 Walker A motif; other site 502025009903 ATP binding site [chemical binding]; other site 502025009904 Walker B motif; other site 502025009905 arginine finger; other site 502025009906 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 502025009907 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 502025009908 RuvA N terminal domain; Region: RuvA_N; pfam01330 502025009909 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 502025009910 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 502025009911 active site 502025009912 putative DNA-binding cleft [nucleotide binding]; other site 502025009913 dimer interface [polypeptide binding]; other site 502025009914 Transcriptional regulator; Region: Transcrip_reg; cl00361 502025009915 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 502025009916 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025009917 catalytic residue [active] 502025009918 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 502025009919 active site 502025009920 dimer interface [polypeptide binding]; other site 502025009921 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025009922 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 502025009923 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 502025009924 putative ligand binding site [chemical binding]; other site 502025009925 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 502025009926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025009927 Walker A/P-loop; other site 502025009928 ATP binding site [chemical binding]; other site 502025009929 Q-loop/lid; other site 502025009930 ABC transporter signature motif; other site 502025009931 Walker B; other site 502025009932 D-loop; other site 502025009933 H-loop/switch region; other site 502025009934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 502025009935 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 502025009936 glycine dehydrogenase; Provisional; Region: PRK05367 502025009937 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 502025009938 tetramer interface [polypeptide binding]; other site 502025009939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025009940 catalytic residue [active] 502025009941 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 502025009942 tetramer interface [polypeptide binding]; other site 502025009943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025009944 catalytic residue [active] 502025009945 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 502025009946 dimer interface [polypeptide binding]; other site 502025009947 allosteric magnesium binding site [ion binding]; other site 502025009948 active site 502025009949 aspartate-rich active site metal binding site; other site 502025009950 Schiff base residues; other site 502025009951 hypothetical protein; Validated; Region: PRK09039 502025009952 hypothetical protein; Validated; Region: PRK09039 502025009953 Leucine rich repeat; Region: LRR_8; pfam13855 502025009954 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025009955 putative catalytic site [active] 502025009956 putative metal binding site [ion binding]; other site 502025009957 putative phosphate binding site [ion binding]; other site 502025009958 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025009959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025009960 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 502025009961 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025009962 minor groove reading motif; other site 502025009963 helix-hairpin-helix signature motif; other site 502025009964 substrate binding pocket [chemical binding]; other site 502025009965 active site 502025009966 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 502025009967 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 502025009968 nudix motif; other site 502025009969 Isochorismatase family; Region: Isochorismatase; pfam00857 502025009970 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025009971 catalytic triad [active] 502025009972 conserved cis-peptide bond; other site 502025009973 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025009974 homotrimer interaction site [polypeptide binding]; other site 502025009975 putative active site [active] 502025009976 pyrimidine utilization protein A; Region: RutA; TIGR03612 502025009977 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 502025009978 active site 502025009979 dimer interface [polypeptide binding]; other site 502025009980 non-prolyl cis peptide bond; other site 502025009981 insertion regions; other site 502025009982 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 502025009983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025009984 FeS/SAM binding site; other site 502025009985 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 502025009986 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 502025009987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025009988 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 502025009989 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 502025009990 putative NAD(P) binding site [chemical binding]; other site 502025009991 catalytic Zn binding site [ion binding]; other site 502025009992 structural Zn binding site [ion binding]; other site 502025009993 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009994 active site 502025009995 ATP binding site [chemical binding]; other site 502025009996 substrate binding site [chemical binding]; other site 502025009997 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025009998 activation loop (A-loop); other site 502025009999 cyclase homology domain; Region: CHD; cd07302 502025010000 nucleotidyl binding site; other site 502025010001 metal binding site [ion binding]; metal-binding site 502025010002 dimer interface [polypeptide binding]; other site 502025010003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010004 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 502025010005 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 502025010006 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 502025010007 catalytic site [active] 502025010008 subunit interface [polypeptide binding]; other site 502025010009 dihydroorotase; Validated; Region: pyrC; PRK09357 502025010010 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025010011 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 502025010012 active site 502025010013 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 502025010014 putative MPT binding site; other site 502025010015 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025010016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025010017 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025010018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010019 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025010020 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025010021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010022 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010023 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010024 phosphopeptide binding site; other site 502025010025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010026 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025010027 Walker A motif; other site 502025010028 ATP binding site [chemical binding]; other site 502025010029 Walker B motif; other site 502025010030 arginine finger; other site 502025010031 Helix-turn-helix domains; Region: HTH; cl00088 502025010032 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 502025010033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010034 binding surface 502025010035 TPR motif; other site 502025010036 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025010037 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025010038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010039 TPR motif; other site 502025010040 binding surface 502025010041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010042 TPR repeat; Region: TPR_11; pfam13414 502025010043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010044 binding surface 502025010045 TPR motif; other site 502025010046 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025010047 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025010048 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 502025010049 periplasmic chaperone; Provisional; Region: PRK10780 502025010050 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 502025010051 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 502025010052 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025010053 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025010054 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025010055 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025010056 Surface antigen; Region: Bac_surface_Ag; cl03097 502025010057 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 502025010058 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025010059 Walker A/P-loop; other site 502025010060 ATP binding site [chemical binding]; other site 502025010061 Q-loop/lid; other site 502025010062 ABC transporter signature motif; other site 502025010063 Walker B; other site 502025010064 D-loop; other site 502025010065 H-loop/switch region; other site 502025010066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025010067 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025010068 FtsX-like permease family; Region: FtsX; cl15850 502025010069 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 502025010070 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 502025010071 dimer interface [polypeptide binding]; other site 502025010072 putative anticodon binding site; other site 502025010073 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 502025010074 motif 1; other site 502025010075 active site 502025010076 motif 2; other site 502025010077 motif 3; other site 502025010078 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025010079 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 502025010080 catalytic residues [active] 502025010081 Creatinine amidohydrolase; Region: Creatininase; cl00618 502025010082 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 502025010083 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 502025010084 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 502025010085 alphaNTD homodimer interface [polypeptide binding]; other site 502025010086 alphaNTD - beta interaction site [polypeptide binding]; other site 502025010087 alphaNTD - beta' interaction site [polypeptide binding]; other site 502025010088 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 502025010089 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 502025010090 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 502025010091 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025010092 RNA binding surface [nucleotide binding]; other site 502025010093 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 502025010094 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 502025010095 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 502025010096 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 502025010097 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 502025010098 active site 502025010099 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 502025010100 SecY translocase; Region: SecY; pfam00344 502025010101 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 502025010102 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 502025010103 23S rRNA binding site [nucleotide binding]; other site 502025010104 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 502025010105 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 502025010106 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 502025010107 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 502025010108 5S rRNA interface [nucleotide binding]; other site 502025010109 23S rRNA interface [nucleotide binding]; other site 502025010110 L5 interface [polypeptide binding]; other site 502025010111 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 502025010112 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 502025010113 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 502025010114 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 502025010115 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 502025010116 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 502025010117 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 502025010118 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 502025010119 KOW motif; Region: KOW; cl00354 502025010120 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 502025010121 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 502025010122 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 502025010123 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 502025010124 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 502025010125 23S rRNA interface [nucleotide binding]; other site 502025010126 5S rRNA interface [nucleotide binding]; other site 502025010127 putative antibiotic binding site [chemical binding]; other site 502025010128 L25 interface [polypeptide binding]; other site 502025010129 L27 interface [polypeptide binding]; other site 502025010130 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 502025010131 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 502025010132 G-X-X-G motif; other site 502025010133 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 502025010134 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 502025010135 putative translocon binding site; other site 502025010136 protein-rRNA interface [nucleotide binding]; other site 502025010137 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 502025010138 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 502025010139 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 502025010140 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 502025010141 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 502025010142 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 502025010143 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 502025010144 elongation factor Tu; Reviewed; Region: PRK00049 502025010145 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 502025010146 G1 box; other site 502025010147 GEF interaction site [polypeptide binding]; other site 502025010148 GTP/Mg2+ binding site [chemical binding]; other site 502025010149 Switch I region; other site 502025010150 G2 box; other site 502025010151 G3 box; other site 502025010152 Switch II region; other site 502025010153 G4 box; other site 502025010154 G5 box; other site 502025010155 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 502025010156 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 502025010157 Antibiotic Binding Site [chemical binding]; other site 502025010158 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 502025010159 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 502025010160 16S rRNA interaction site [nucleotide binding]; other site 502025010161 streptomycin interaction site [chemical binding]; other site 502025010162 23S rRNA interaction site [nucleotide binding]; other site 502025010163 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 502025010164 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025010165 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025010166 Family description; Region: VCBS; pfam13517 502025010167 Family description; Region: VCBS; pfam13517 502025010168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010170 active site 502025010171 ATP binding site [chemical binding]; other site 502025010172 substrate binding site [chemical binding]; other site 502025010173 activation loop (A-loop); other site 502025010174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025010175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 502025010177 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 502025010178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010179 NAD(P) binding site [chemical binding]; other site 502025010180 active site 502025010181 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 502025010182 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 502025010183 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 502025010184 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 502025010185 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 502025010186 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 502025010187 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 502025010188 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 502025010189 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 502025010190 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 502025010191 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 502025010192 DNA binding site [nucleotide binding] 502025010193 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 502025010194 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 502025010195 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 502025010196 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 502025010197 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 502025010198 RPB11 interaction site [polypeptide binding]; other site 502025010199 RPB12 interaction site [polypeptide binding]; other site 502025010200 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 502025010201 RPB3 interaction site [polypeptide binding]; other site 502025010202 RPB1 interaction site [polypeptide binding]; other site 502025010203 RPB11 interaction site [polypeptide binding]; other site 502025010204 RPB10 interaction site [polypeptide binding]; other site 502025010205 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 502025010206 peripheral dimer interface [polypeptide binding]; other site 502025010207 core dimer interface [polypeptide binding]; other site 502025010208 L10 interface [polypeptide binding]; other site 502025010209 L11 interface [polypeptide binding]; other site 502025010210 putative EF-Tu interaction site [polypeptide binding]; other site 502025010211 putative EF-G interaction site [polypeptide binding]; other site 502025010212 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 502025010213 23S rRNA interface [nucleotide binding]; other site 502025010214 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 502025010215 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 502025010216 mRNA/rRNA interface [nucleotide binding]; other site 502025010217 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 502025010218 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 502025010219 putative homodimer interface [polypeptide binding]; other site 502025010220 KOW motif; Region: KOW; cl00354 502025010221 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 502025010222 elongation factor Tu; Reviewed; Region: PRK00049 502025010223 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 502025010224 G1 box; other site 502025010225 GEF interaction site [polypeptide binding]; other site 502025010226 GTP/Mg2+ binding site [chemical binding]; other site 502025010227 Switch I region; other site 502025010228 G2 box; other site 502025010229 G3 box; other site 502025010230 Switch II region; other site 502025010231 G4 box; other site 502025010232 G5 box; other site 502025010233 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 502025010234 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 502025010235 Antibiotic Binding Site [chemical binding]; other site 502025010236 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 502025010237 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 502025010238 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025010239 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025010240 NAD(P) binding site [chemical binding]; other site 502025010241 catalytic residues [active] 502025010242 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 502025010243 23S rRNA interface [nucleotide binding]; other site 502025010244 L3 interface [polypeptide binding]; other site 502025010245 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 502025010246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025010247 dimer interface [polypeptide binding]; other site 502025010248 phosphorylation site [posttranslational modification] 502025010249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010250 ATP binding site [chemical binding]; other site 502025010251 Mg2+ binding site [ion binding]; other site 502025010252 G-X-G motif; other site 502025010253 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025010254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010255 active site 502025010256 phosphorylation site [posttranslational modification] 502025010257 intermolecular recognition site; other site 502025010258 dimerization interface [polypeptide binding]; other site 502025010259 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010261 active site 502025010262 phosphorylation site [posttranslational modification] 502025010263 intermolecular recognition site; other site 502025010264 dimerization interface [polypeptide binding]; other site 502025010265 Sulfatase; Region: Sulfatase; cl10460 502025010266 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 502025010267 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025010268 ligand binding site [chemical binding]; other site 502025010269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025010270 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 502025010271 ApbE family; Region: ApbE; cl00643 502025010272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025010273 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 502025010274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010275 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025010276 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 502025010277 Cation transport protein; Region: TrkH; cl10514 502025010278 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 502025010279 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025010280 active site 502025010281 motif I; other site 502025010282 motif II; other site 502025010283 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025010284 active site 502025010285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025010286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025010287 sensor protein ZraS; Provisional; Region: PRK10364 502025010288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010289 ATP binding site [chemical binding]; other site 502025010290 Mg2+ binding site [ion binding]; other site 502025010291 G-X-G motif; other site 502025010292 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 502025010293 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 502025010294 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 502025010295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010296 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 502025010297 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010299 active site 502025010300 phosphorylation site [posttranslational modification] 502025010301 intermolecular recognition site; other site 502025010302 dimerization interface [polypeptide binding]; other site 502025010303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025010304 metal binding site [ion binding]; metal-binding site 502025010305 active site 502025010306 I-site; other site 502025010307 UbiA prenyltransferase family; Region: UbiA; cl00337 502025010308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010309 active site 502025010310 ATP binding site [chemical binding]; other site 502025010311 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010312 substrate binding site [chemical binding]; other site 502025010313 activation loop (A-loop); other site 502025010314 Predicted ATPase [General function prediction only]; Region: COG3899 502025010315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010316 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025010317 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025010318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010319 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010320 active site 502025010321 ATP binding site [chemical binding]; other site 502025010322 substrate binding site [chemical binding]; other site 502025010323 activation loop (A-loop); other site 502025010324 Predicted ATPase [General function prediction only]; Region: COG3899 502025010325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010326 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010327 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010328 active site 502025010329 ATP binding site [chemical binding]; other site 502025010330 substrate binding site [chemical binding]; other site 502025010331 activation loop (A-loop); other site 502025010332 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 502025010333 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 502025010334 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 502025010335 generic binding surface I; other site 502025010336 generic binding surface II; other site 502025010337 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025010338 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 502025010339 active site pocket [active] 502025010340 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 502025010341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025010343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025010344 catalytic residue [active] 502025010345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010346 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025010347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010348 NAD(P) binding pocket [chemical binding]; other site 502025010349 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 502025010350 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010351 ligand binding site [chemical binding]; other site 502025010352 flexible hinge region; other site 502025010353 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010354 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010355 active site 502025010356 ATP binding site [chemical binding]; other site 502025010357 substrate binding site [chemical binding]; other site 502025010358 activation loop (A-loop); other site 502025010359 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010360 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010361 active site 502025010362 ATP binding site [chemical binding]; other site 502025010363 substrate binding site [chemical binding]; other site 502025010364 activation loop (A-loop); other site 502025010365 Predicted ATPase [General function prediction only]; Region: COG3899 502025010366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010367 Adenosylhomocysteinase; Provisional; Region: PTZ00075 502025010368 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 502025010369 oligomerization interface [polypeptide binding]; other site 502025010370 active site 502025010371 NAD+ binding site [chemical binding]; other site 502025010372 Pectinacetylesterase; Region: PAE; pfam03283 502025010373 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 502025010374 putative active site [active] 502025010375 catalytic site [active] 502025010376 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 502025010377 PLD-like domain; Region: PLDc_2; pfam13091 502025010378 putative active site [active] 502025010379 catalytic site [active] 502025010380 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 502025010381 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 502025010382 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025010383 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025010384 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025010385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010386 ligand binding site [chemical binding]; other site 502025010387 flexible hinge region; other site 502025010388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 502025010389 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 502025010390 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 502025010391 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025010392 metal ion-dependent adhesion site (MIDAS); other site 502025010393 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 502025010394 Predicted ATPase [General function prediction only]; Region: COG4637 502025010395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010396 Walker A/P-loop; other site 502025010397 ATP binding site [chemical binding]; other site 502025010398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010399 ABC transporter signature motif; other site 502025010400 Walker B; other site 502025010401 D-loop; other site 502025010402 H-loop/switch region; other site 502025010403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025010404 glycogen branching enzyme; Provisional; Region: PRK12313 502025010405 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 502025010406 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 502025010407 active site 502025010408 catalytic site [active] 502025010409 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 502025010410 trehalose synthase; Region: treS_nterm; TIGR02456 502025010411 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 502025010412 active site 502025010413 catalytic site [active] 502025010414 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 502025010415 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 502025010416 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 502025010417 active site 502025010418 homodimer interface [polypeptide binding]; other site 502025010419 catalytic site [active] 502025010420 acceptor binding site [chemical binding]; other site 502025010421 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 502025010422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025010423 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010424 active site 502025010425 ATP binding site [chemical binding]; other site 502025010426 substrate binding site [chemical binding]; other site 502025010427 activation loop (A-loop); other site 502025010428 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010431 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 502025010432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010433 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010434 ligand binding site [chemical binding]; other site 502025010435 flexible hinge region; other site 502025010436 Helix-turn-helix domains; Region: HTH; cl00088 502025010437 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010438 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010439 ligand binding site [chemical binding]; other site 502025010440 flexible hinge region; other site 502025010441 Helix-turn-helix domains; Region: HTH; cl00088 502025010442 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 502025010443 thiS-thiF/thiG interaction site; other site 502025010444 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 502025010445 ThiS interaction site; other site 502025010446 putative active site [active] 502025010447 tetramer interface [polypeptide binding]; other site 502025010448 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 502025010449 active site 502025010450 pyrophosphate binding site [ion binding]; other site 502025010451 thiamine phosphate binding site [chemical binding]; other site 502025010452 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025010453 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025010454 active site 502025010455 oxyanion hole [active] 502025010456 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 502025010457 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 502025010458 putative active site [active] 502025010459 catalytic triad [active] 502025010460 putative dimer interface [polypeptide binding]; other site 502025010461 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 502025010462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025010463 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 502025010464 elongation factor G; Reviewed; Region: PRK12740 502025010465 G1 box; other site 502025010466 putative GEF interaction site [polypeptide binding]; other site 502025010467 GTP/Mg2+ binding site [chemical binding]; other site 502025010468 Switch I region; other site 502025010469 G2 box; other site 502025010470 G3 box; other site 502025010471 Switch II region; other site 502025010472 G4 box; other site 502025010473 G5 box; other site 502025010474 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 502025010475 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 502025010476 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025010477 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 502025010478 Tetramer interface [polypeptide binding]; other site 502025010479 active site 502025010480 FMN-binding site [chemical binding]; other site 502025010481 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 502025010482 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010484 active site 502025010485 ATP binding site [chemical binding]; other site 502025010486 substrate binding site [chemical binding]; other site 502025010487 activation loop (A-loop); other site 502025010488 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 502025010489 iron-sulfur cluster [ion binding]; other site 502025010490 [2Fe-2S] cluster binding site [ion binding]; other site 502025010491 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025010492 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 502025010493 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 502025010494 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 502025010495 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 502025010496 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025010497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025010498 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025010499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010500 active site 502025010501 ATP binding site [chemical binding]; other site 502025010502 substrate binding site [chemical binding]; other site 502025010503 activation loop (A-loop); other site 502025010504 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010505 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 502025010508 Smr domain; Region: Smr; cl02619 502025010509 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 502025010510 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 502025010511 tetramer interface [polypeptide binding]; other site 502025010512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025010513 catalytic residue [active] 502025010514 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025010515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010516 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 502025010517 Walker A/P-loop; other site 502025010518 ATP binding site [chemical binding]; other site 502025010519 Q-loop/lid; other site 502025010520 ABC transporter signature motif; other site 502025010521 Walker B; other site 502025010522 D-loop; other site 502025010523 H-loop/switch region; other site 502025010524 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010525 active site 502025010526 ATP binding site [chemical binding]; other site 502025010527 substrate binding site [chemical binding]; other site 502025010528 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010529 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025010530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025010531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025010532 DNA binding residues [nucleotide binding] 502025010533 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 502025010534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025010535 D-aminopeptidase; Reviewed; Region: PRK13128 502025010536 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 502025010537 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 502025010538 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025010539 CoenzymeA binding site [chemical binding]; other site 502025010540 subunit interaction site [polypeptide binding]; other site 502025010541 PHB binding site; other site 502025010542 trehalose synthase; Region: treS_nterm; TIGR02456 502025010543 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 502025010544 Ca binding site [ion binding]; other site 502025010545 active site 502025010546 catalytic site [active] 502025010547 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 502025010548 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025010549 intersubunit interface [polypeptide binding]; other site 502025010550 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 502025010551 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025010552 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025010553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010554 TPR motif; other site 502025010555 binding surface 502025010556 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025010557 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025010558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025010559 binding surface 502025010560 TPR motif; other site 502025010561 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025010562 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025010563 active site 502025010564 zinc binding site [ion binding]; other site 502025010565 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025010566 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025010567 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 502025010568 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 502025010569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025010570 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025010571 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025010572 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010573 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 502025010574 Na2 binding site [ion binding]; other site 502025010575 putative substrate binding site 1 [chemical binding]; other site 502025010576 Na binding site 1 [ion binding]; other site 502025010577 putative substrate binding site 2 [chemical binding]; other site 502025010578 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 502025010579 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 502025010580 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025010581 Double zinc ribbon; Region: DZR; pfam12773 502025010582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025010583 S-adenosylmethionine binding site [chemical binding]; other site 502025010584 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025010585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010586 active site 502025010587 phosphorylation site [posttranslational modification] 502025010588 intermolecular recognition site; other site 502025010589 dimerization interface [polypeptide binding]; other site 502025010590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010591 Walker A motif; other site 502025010592 ATP binding site [chemical binding]; other site 502025010593 Walker B motif; other site 502025010594 arginine finger; other site 502025010595 Helix-turn-helix domains; Region: HTH; cl00088 502025010596 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 502025010597 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 502025010598 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025010599 Restriction endonuclease; Region: Mrr_cat; cl00516 502025010600 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 502025010601 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 502025010602 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025010603 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 502025010604 Transglycosylase; Region: Transgly; cl07896 502025010605 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 502025010606 active site 502025010607 metal binding site [ion binding]; metal-binding site 502025010608 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025010609 putative catalytic site [active] 502025010610 putative metal binding site [ion binding]; other site 502025010611 putative phosphate binding site [ion binding]; other site 502025010612 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 502025010613 Putative zinc-finger; Region: zf-HC2; cl15806 502025010614 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025010615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025010616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025010617 DNA binding residues [nucleotide binding] 502025010618 Sulfatase; Region: Sulfatase; cl10460 502025010619 AMMECR1; Region: AMMECR1; cl00911 502025010620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 502025010621 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 502025010622 motif 1; other site 502025010623 dimer interface [polypeptide binding]; other site 502025010624 active site 502025010625 motif 2; other site 502025010626 motif 3; other site 502025010627 elongation factor P; Validated; Region: PRK00529 502025010628 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 502025010629 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 502025010630 RNA binding site [nucleotide binding]; other site 502025010631 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 502025010632 RNA binding site [nucleotide binding]; other site 502025010633 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010634 phosphopeptide binding site; other site 502025010635 Rrf2 family protein; Region: rrf2_super; TIGR00738 502025010636 Helix-turn-helix domains; Region: HTH; cl00088 502025010637 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025010638 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025010639 dimer interface [polypeptide binding]; other site 502025010640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025010641 catalytic residue [active] 502025010642 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 502025010643 ATP binding site [chemical binding]; other site 502025010644 substrate interface [chemical binding]; other site 502025010645 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 502025010646 MoaE interaction surface [polypeptide binding]; other site 502025010647 MoeB interaction surface [polypeptide binding]; other site 502025010648 thiocarboxylated glycine; other site 502025010649 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025010650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025010651 dimer interface [polypeptide binding]; other site 502025010652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025010653 catalytic residue [active] 502025010654 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 502025010655 DsrE/DsrF-like family; Region: DrsE; cl00672 502025010656 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025010657 CPxP motif; other site 502025010658 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025010659 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 502025010660 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 502025010661 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 502025010662 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 502025010663 Ligand Binding Site [chemical binding]; other site 502025010664 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025010665 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 502025010666 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 502025010667 Flavoprotein; Region: Flavoprotein; cl08021 502025010668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025010669 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 502025010670 FAD binding site [chemical binding]; other site 502025010671 substrate binding site [chemical binding]; other site 502025010672 catalytic base [active] 502025010673 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 502025010674 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 502025010675 dimer interaction site [polypeptide binding]; other site 502025010676 substrate-binding tunnel; other site 502025010677 active site 502025010678 catalytic site [active] 502025010679 substrate binding site [chemical binding]; other site 502025010680 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 502025010681 active site 502025010682 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 502025010683 elongation factor G; Reviewed; Region: PRK00007 502025010684 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 502025010685 G1 box; other site 502025010686 putative GEF interaction site [polypeptide binding]; other site 502025010687 GTP/Mg2+ binding site [chemical binding]; other site 502025010688 Switch I region; other site 502025010689 G2 box; other site 502025010690 G3 box; other site 502025010691 Switch II region; other site 502025010692 G4 box; other site 502025010693 G5 box; other site 502025010694 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 502025010695 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 502025010696 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025010697 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 502025010698 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 502025010699 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025010700 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025010701 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 502025010702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025010703 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025010704 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 502025010705 IMP binding site; other site 502025010706 dimer interface [polypeptide binding]; other site 502025010707 partial ornithine binding site; other site 502025010708 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 502025010709 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 502025010710 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025010711 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 502025010712 active site 502025010713 dinuclear metal binding site [ion binding]; other site 502025010714 dimerization interface [polypeptide binding]; other site 502025010715 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 502025010716 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025010717 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 502025010718 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 502025010719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 502025010720 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 502025010721 active site 502025010722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010724 hydroperoxidase II; Provisional; Region: katE; PRK11249 502025010725 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 502025010726 tetramer interface [polypeptide binding]; other site 502025010727 heme binding pocket [chemical binding]; other site 502025010728 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 502025010729 domain interactions; other site 502025010730 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 502025010731 Malic enzyme, N-terminal domain; Region: malic; pfam00390 502025010732 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 502025010733 putative NAD(P) binding site [chemical binding]; other site 502025010734 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 502025010735 PilZ domain; Region: PilZ; cl01260 502025010736 hypothetical protein; Validated; Region: PRK07198 502025010737 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 502025010738 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 502025010739 dimerization interface [polypeptide binding]; other site 502025010740 active site 502025010741 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 502025010742 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025010743 active site 502025010744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010746 active site 502025010747 ATP binding site [chemical binding]; other site 502025010748 substrate binding site [chemical binding]; other site 502025010749 activation loop (A-loop); other site 502025010750 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010751 phosphopeptide binding site; other site 502025010752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010753 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025010754 Walker A motif; other site 502025010755 ATP binding site [chemical binding]; other site 502025010756 Walker B motif; other site 502025010757 arginine finger; other site 502025010758 Helix-turn-helix domains; Region: HTH; cl00088 502025010759 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010761 active site 502025010762 ATP binding site [chemical binding]; other site 502025010763 substrate binding site [chemical binding]; other site 502025010764 activation loop (A-loop); other site 502025010765 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025010766 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025010767 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010768 phosphopeptide binding site; other site 502025010769 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025010770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025010771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025010772 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 502025010773 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 502025010774 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 502025010775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010776 G1 box; other site 502025010777 GTP/Mg2+ binding site [chemical binding]; other site 502025010778 G2 box; other site 502025010779 Switch I region; other site 502025010780 G3 box; other site 502025010781 Switch II region; other site 502025010782 G4 box; other site 502025010783 G5 box; other site 502025010784 Nucleoside recognition; Region: Gate; cl00486 502025010785 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 502025010786 Nucleoside recognition; Region: Gate; cl00486 502025010787 FeoA domain; Region: FeoA; cl00838 502025010788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025010789 sequence-specific DNA binding site [nucleotide binding]; other site 502025010790 salt bridge; other site 502025010791 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 502025010792 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 502025010793 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 502025010794 active site 502025010795 substrate binding site [chemical binding]; other site 502025010796 metal binding site [ion binding]; metal-binding site 502025010797 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 502025010798 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 502025010799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025010800 FeS/SAM binding site; other site 502025010801 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025010802 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 502025010803 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 502025010804 Cupin domain; Region: Cupin_2; cl09118 502025010805 Cupin domain; Region: Cupin_2; cl09118 502025010806 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 502025010807 intersubunit interface [polypeptide binding]; other site 502025010808 active site 502025010809 Zn2+ binding site [ion binding]; other site 502025010810 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 502025010811 Cupin domain; Region: Cupin_2; cl09118 502025010812 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025010813 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025010814 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 502025010815 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025010816 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025010817 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025010818 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 502025010819 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 502025010820 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025010821 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025010822 active site 502025010823 phosphorylation site [posttranslational modification] 502025010824 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 502025010825 LabA_like proteins; Region: LabA_like; cd06167 502025010826 putative metal binding site [ion binding]; other site 502025010827 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025010828 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 502025010829 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 502025010830 G1 box; other site 502025010831 putative GEF interaction site [polypeptide binding]; other site 502025010832 GTP/Mg2+ binding site [chemical binding]; other site 502025010833 Switch I region; other site 502025010834 G2 box; other site 502025010835 G3 box; other site 502025010836 Switch II region; other site 502025010837 G4 box; other site 502025010838 G5 box; other site 502025010839 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 502025010840 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 502025010841 malate dehydrogenase; Provisional; Region: PRK05442 502025010842 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 502025010843 NAD(P) binding site [chemical binding]; other site 502025010844 dimer interface [polypeptide binding]; other site 502025010845 malate binding site [chemical binding]; other site 502025010846 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 502025010847 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 502025010848 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025010849 N-terminal plug; other site 502025010850 ligand-binding site [chemical binding]; other site 502025010851 S-adenosylmethionine synthetase; Validated; Region: PRK05250 502025010852 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 502025010853 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 502025010854 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 502025010855 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 502025010856 histidinol dehydrogenase; Region: hisD; TIGR00069 502025010857 NAD binding site [chemical binding]; other site 502025010858 dimerization interface [polypeptide binding]; other site 502025010859 product binding site; other site 502025010860 substrate binding site [chemical binding]; other site 502025010861 zinc binding site [ion binding]; other site 502025010862 catalytic residues [active] 502025010863 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025010864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025010865 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 502025010866 FeS/SAM binding site; other site 502025010867 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025010868 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025010869 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025010870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025010871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025010872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010873 ATP binding site [chemical binding]; other site 502025010874 G-X-G motif; other site 502025010875 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025010876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010877 active site 502025010878 phosphorylation site [posttranslational modification] 502025010879 intermolecular recognition site; other site 502025010880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010881 Walker A motif; other site 502025010882 ATP binding site [chemical binding]; other site 502025010883 Walker B motif; other site 502025010884 arginine finger; other site 502025010885 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 502025010886 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010887 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010888 active site 502025010889 ATP binding site [chemical binding]; other site 502025010890 substrate binding site [chemical binding]; other site 502025010891 activation loop (A-loop); other site 502025010892 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025010893 putative active site [active] 502025010894 putative metal binding site [ion binding]; other site 502025010895 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025010896 Ca binding site [ion binding]; other site 502025010897 ligand binding site I [chemical binding]; other site 502025010898 homodimer interface [polypeptide binding]; other site 502025010899 ligand binding site II [chemical binding]; other site 502025010900 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 502025010901 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025010902 Ca binding site [ion binding]; other site 502025010903 ligand binding site I [chemical binding]; other site 502025010904 homodimer interface [polypeptide binding]; other site 502025010905 ligand binding site II [chemical binding]; other site 502025010906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025010907 ligand binding site [chemical binding]; other site 502025010908 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 502025010909 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 502025010910 MOFRL family; Region: MOFRL; pfam05161 502025010911 trehalose synthase; Region: treS_nterm; TIGR02456 502025010912 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 502025010913 Ca binding site [ion binding]; other site 502025010914 active site 502025010915 catalytic site [active] 502025010916 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025010917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025010918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025010919 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025010920 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 502025010921 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025010922 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 502025010923 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010925 active site 502025010926 ATP binding site [chemical binding]; other site 502025010927 substrate binding site [chemical binding]; other site 502025010928 activation loop (A-loop); other site 502025010929 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025010930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025010931 active site 502025010932 catalytic tetrad [active] 502025010933 Predicted membrane protein [Function unknown]; Region: COG4270 502025010934 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 502025010935 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 502025010936 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025010937 Cu(I) binding site [ion binding]; other site 502025010938 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 502025010939 Cytochrome c; Region: Cytochrom_C; cl11414 502025010940 acetylglutamate kinase; Provisional; Region: PRK04531 502025010941 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025010942 nucleotide binding site [chemical binding]; other site 502025010943 substrate binding site [chemical binding]; other site 502025010944 DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; Region: DUF619-like; cl14605 502025010945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010946 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 502025010947 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 502025010948 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025010949 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 502025010950 NADP binding site [chemical binding]; other site 502025010951 substrate binding site [chemical binding]; other site 502025010952 active site 502025010953 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025010954 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025010955 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 502025010956 NAD binding site [chemical binding]; other site 502025010957 Phe binding site; other site 502025010958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025010959 non-specific DNA binding site [nucleotide binding]; other site 502025010960 salt bridge; other site 502025010961 sequence-specific DNA binding site [nucleotide binding]; other site 502025010962 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 502025010963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025010964 Walker A/P-loop; other site 502025010965 ATP binding site [chemical binding]; other site 502025010966 Q-loop/lid; other site 502025010967 ABC transporter signature motif; other site 502025010968 Walker B; other site 502025010969 D-loop; other site 502025010970 H-loop/switch region; other site 502025010971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025010972 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 502025010973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025010974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025010975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025010976 RNA polymerase factor sigma-70; Validated; Region: PRK08241 502025010977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025010978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025010979 DNA binding residues [nucleotide binding] 502025010980 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025010981 Helix-turn-helix domains; Region: HTH; cl00088 502025010982 Outer membrane efflux protein; Region: OEP; pfam02321 502025010983 Outer membrane efflux protein; Region: OEP; pfam02321 502025010984 pyruvate carboxylase subunit B; Validated; Region: PRK09282 502025010985 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025010986 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025010987 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025010988 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 502025010989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025010990 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 502025010991 dimer interface [polypeptide binding]; other site 502025010992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025010993 ligand binding site [chemical binding]; other site 502025010994 MbtH-like protein; Region: MbtH; cl01279 502025010995 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 502025010996 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 502025010997 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 502025010998 Walker A/P-loop; other site 502025010999 ATP binding site [chemical binding]; other site 502025011000 Q-loop/lid; other site 502025011001 ABC transporter signature motif; other site 502025011002 Walker B; other site 502025011003 D-loop; other site 502025011004 H-loop/switch region; other site 502025011005 TOBE domain; Region: TOBE_2; cl01440 502025011006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025011008 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 502025011009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025011010 dimer interface [polypeptide binding]; other site 502025011011 conserved gate region; other site 502025011012 putative PBP binding loops; other site 502025011013 ABC-ATPase subunit interface; other site 502025011014 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025011015 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025011016 Right handed beta helix region; Region: Beta_helix; pfam13229 502025011017 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 502025011018 GAF domain; Region: GAF; cl15785 502025011019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011020 Walker A motif; other site 502025011021 ATP binding site [chemical binding]; other site 502025011022 Walker B motif; other site 502025011023 arginine finger; other site 502025011024 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025011025 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025011026 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025011027 active site 502025011028 metal binding site [ion binding]; metal-binding site 502025011029 Cytochrome c [Energy production and conversion]; Region: COG3258 502025011030 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025011031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025011032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025011033 ethanolamine permease; Region: 2A0305; TIGR00908 502025011034 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025011035 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 502025011036 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 502025011037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011038 catalytic residue [active] 502025011039 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025011040 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025011041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025011042 catalytic residue [active] 502025011043 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 502025011044 active site 502025011045 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025011046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011047 S-adenosylmethionine binding site [chemical binding]; other site 502025011048 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 502025011049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025011050 active site residue [active] 502025011051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011052 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025011053 active site residue [active] 502025011054 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 502025011055 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025011056 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025011057 active site 502025011058 catalytic residues [active] 502025011059 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 502025011060 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025011061 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025011062 HflX GTPase family; Region: HflX; cd01878 502025011063 G1 box; other site 502025011064 GTP/Mg2+ binding site [chemical binding]; other site 502025011065 Switch I region; other site 502025011066 G2 box; other site 502025011067 G3 box; other site 502025011068 Switch II region; other site 502025011069 G4 box; other site 502025011070 G5 box; other site 502025011071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011073 active site 502025011074 ATP binding site [chemical binding]; other site 502025011075 substrate binding site [chemical binding]; other site 502025011076 activation loop (A-loop); other site 502025011077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011078 active site 502025011079 ATP binding site [chemical binding]; other site 502025011080 substrate binding site [chemical binding]; other site 502025011081 activation loop (A-loop); other site 502025011082 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 502025011083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011084 oligomerization interface [polypeptide binding]; other site 502025011085 active site 502025011086 NAD+ binding site [chemical binding]; other site 502025011087 Helix-turn-helix domains; Region: HTH; cl00088 502025011088 Winged helix-turn helix; Region: HTH_29; pfam13551 502025011089 Helix-turn-helix domains; Region: HTH; cl00088 502025011090 Integrase core domain; Region: rve; cl01316 502025011091 Integrase core domain; Region: rve_3; cl15866 502025011092 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025011093 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025011094 putative di-iron ligands [ion binding]; other site 502025011095 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025011096 B12 binding site [chemical binding]; other site 502025011097 aspartate semialdehyde dehydrogenase; Region: PLN02383 502025011098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011099 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 502025011100 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025011101 nucleotide binding site [chemical binding]; other site 502025011102 substrate binding site [chemical binding]; other site 502025011103 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 502025011104 substrate binding site [chemical binding]; other site 502025011105 B12 cofactor binding site [chemical binding]; other site 502025011106 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 502025011107 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 502025011108 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 502025011109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011110 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 502025011111 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025011112 inhibitor-cofactor binding pocket; inhibition site 502025011113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011114 catalytic residue [active] 502025011115 EamA-like transporter family; Region: EamA; cl01037 502025011116 EamA-like transporter family; Region: EamA; cl01037 502025011117 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011118 phosphopeptide binding site; other site 502025011119 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025011120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011121 Walker A motif; other site 502025011122 ATP binding site [chemical binding]; other site 502025011123 Walker B motif; other site 502025011124 Helix-turn-helix domains; Region: HTH; cl00088 502025011125 Helix-turn-helix domains; Region: HTH; cl00088 502025011126 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 502025011127 active site 502025011128 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 502025011129 Protein of unknown function (DUF971); Region: DUF971; cl01414 502025011130 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 502025011131 substrate binding pocket [chemical binding]; other site 502025011132 active site 502025011133 iron coordination sites [ion binding]; other site 502025011134 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011135 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025011136 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011137 NAD(P) binding site [chemical binding]; other site 502025011138 catalytic residues [active] 502025011139 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 502025011140 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 502025011141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025011142 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 502025011143 putative dimer interface [polypeptide binding]; other site 502025011144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025011145 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 502025011146 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 502025011147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011148 NAD(P) binding pocket [chemical binding]; other site 502025011149 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025011150 CpXC protein; Region: CpXC; pfam14353 502025011151 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025011152 Flagellin N-methylase; Region: FliB; cl00497 502025011153 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025011154 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025011155 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025011156 Peptidase family M48; Region: Peptidase_M48; cl12018 502025011157 Helix-turn-helix domains; Region: HTH; cl00088 502025011158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 502025011159 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 502025011160 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 502025011161 dimer interface [polypeptide binding]; other site 502025011162 active site 502025011163 Uncharacterized conserved protein [Function unknown]; Region: COG4850 502025011164 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 502025011165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025011166 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025011167 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025011168 structural tetrad; other site 502025011169 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025011170 structural tetrad; other site 502025011171 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025011172 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025011173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025011174 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025011175 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 502025011176 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025011177 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025011178 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011179 Stage II sporulation protein; Region: SpoIID; pfam08486 502025011180 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 502025011181 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025011182 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 502025011183 classical (c) SDRs; Region: SDR_c; cd05233 502025011184 NAD(P) binding site [chemical binding]; other site 502025011185 active site 502025011186 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 502025011187 active site clefts [active] 502025011188 zinc binding site [ion binding]; other site 502025011189 dimer interface [polypeptide binding]; other site 502025011190 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025011191 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025011192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 502025011193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 502025011194 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 502025011195 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 502025011196 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 502025011197 Sulfate transporter family; Region: Sulfate_transp; cl15842 502025011198 Sulfate transporter family; Region: Sulfate_transp; cl15842 502025011199 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 502025011200 Helix-turn-helix domains; Region: HTH; cl00088 502025011201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025011203 putative substrate translocation pore; other site 502025011204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011205 Predicted peptidase [General function prediction only]; Region: COG4099 502025011206 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025011207 hypothetical protein; Provisional; Region: PRK08317 502025011208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011209 S-adenosylmethionine binding site [chemical binding]; other site 502025011210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025011211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011212 NAD(P) binding site [chemical binding]; other site 502025011213 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025011214 active site 502025011215 Helix-turn-helix domains; Region: HTH; cl00088 502025011216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025011217 dimerization interface [polypeptide binding]; other site 502025011218 TIR domain; Region: TIR_2; cl15770 502025011219 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 502025011220 dimer interface [polypeptide binding]; other site 502025011221 substrate binding site [chemical binding]; other site 502025011222 metal binding sites [ion binding]; metal-binding site 502025011223 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 502025011224 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 502025011225 heme binding site [chemical binding]; other site 502025011226 ferroxidase pore; other site 502025011227 ferroxidase diiron center [ion binding]; other site 502025011228 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 502025011229 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025011230 Hexamer/Pentamer interface [polypeptide binding]; other site 502025011231 central pore; other site 502025011232 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025011233 Hexamer/Pentamer interface [polypeptide binding]; other site 502025011234 central pore; other site 502025011235 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 502025011236 intersubunit interface [polypeptide binding]; other site 502025011237 active site 502025011238 Zn2+ binding site [ion binding]; other site 502025011239 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 502025011240 pyruvate kinase; Provisional; Region: PRK05826 502025011241 domain interfaces; other site 502025011242 active site 502025011243 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 502025011244 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 502025011245 active site 502025011246 intersubunit interface [polypeptide binding]; other site 502025011247 catalytic residue [active] 502025011248 Dehydratase family; Region: ILVD_EDD; cl00340 502025011249 6-phosphogluconate dehydratase; Region: edd; TIGR01196 502025011250 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 502025011251 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 502025011252 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 502025011253 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 502025011254 putative active site [active] 502025011255 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025011256 putative catalytic site [active] 502025011257 putative metal binding site [ion binding]; other site 502025011258 putative phosphate binding site [ion binding]; other site 502025011259 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 502025011260 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025011261 Transglycosylase; Region: Transgly; cl07896 502025011262 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025011263 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025011264 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 502025011265 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025011266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025011267 dimerization interface [polypeptide binding]; other site 502025011268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025011269 dimer interface [polypeptide binding]; other site 502025011270 phosphorylation site [posttranslational modification] 502025011271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011272 ATP binding site [chemical binding]; other site 502025011273 G-X-G motif; other site 502025011274 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011276 active site 502025011277 phosphorylation site [posttranslational modification] 502025011278 intermolecular recognition site; other site 502025011279 dimerization interface [polypeptide binding]; other site 502025011280 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 502025011281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025011282 GAF domain; Region: GAF_2; pfam13185 502025011283 GAF domain; Region: GAF; cl15785 502025011284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025011285 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 502025011286 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 502025011287 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025011288 active site 502025011289 catalytic site [active] 502025011290 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025011291 anti sigma factor interaction site; other site 502025011292 regulatory phosphorylation site [posttranslational modification]; other site 502025011293 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011295 active site 502025011296 phosphorylation site [posttranslational modification] 502025011297 intermolecular recognition site; other site 502025011298 dimerization interface [polypeptide binding]; other site 502025011299 GAF domain; Region: GAF_2; pfam13185 502025011300 GAF domain; Region: GAF; cl15785 502025011301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025011302 Zn2+ binding site [ion binding]; other site 502025011303 Mg2+ binding site [ion binding]; other site 502025011304 Type III pantothenate kinase; Region: Pan_kinase; cl09130 502025011305 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025011306 catalytic residues [active] 502025011307 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 502025011308 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025011309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025011310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025011312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025011313 active site 502025011314 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025011315 Protein of unknown function (DUF523); Region: DUF523; cl00733 502025011316 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 502025011317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011318 TIGR01777 family protein; Region: yfcH 502025011319 NAD(P) binding site [chemical binding]; other site 502025011320 active site 502025011321 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 502025011322 putative hydrophobic ligand binding site [chemical binding]; other site 502025011323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025011324 non-specific DNA binding site [nucleotide binding]; other site 502025011325 salt bridge; other site 502025011326 sequence-specific DNA binding site [nucleotide binding]; other site 502025011327 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025011328 FOG: CBS domain [General function prediction only]; Region: COG0517 502025011329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 502025011330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025011331 ligand binding site [chemical binding]; other site 502025011332 flexible hinge region; other site 502025011333 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 502025011334 trimer interface [polypeptide binding]; other site 502025011335 dimer interface [polypeptide binding]; other site 502025011336 putative active site [active] 502025011337 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 502025011338 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 502025011339 glutaminase active site [active] 502025011340 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 502025011341 dimer interface [polypeptide binding]; other site 502025011342 active site 502025011343 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 502025011344 dimer interface [polypeptide binding]; other site 502025011345 active site 502025011346 Ubiquitin-like proteins; Region: UBQ; cl00155 502025011347 BNR repeat-like domain; Region: BNR_2; pfam13088 502025011348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025011349 TPR motif; other site 502025011350 binding surface 502025011351 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 502025011352 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 502025011353 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 502025011354 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 502025011355 GDP-binding site [chemical binding]; other site 502025011356 ACT binding site; other site 502025011357 IMP binding site; other site 502025011358 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 502025011359 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 502025011360 dimer interface [polypeptide binding]; other site 502025011361 motif 1; other site 502025011362 active site 502025011363 motif 2; other site 502025011364 motif 3; other site 502025011365 ATP synthase subunit C; Region: ATP-synt_C; cl00466 502025011366 ATP synthase A chain; Region: ATP-synt_A; cl00413 502025011367 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 502025011368 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 502025011369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025011370 inhibitor-cofactor binding pocket; inhibition site 502025011371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011372 catalytic residue [active] 502025011373 DNA gyrase subunit A; Validated; Region: PRK05560 502025011374 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 502025011375 CAP-like domain; other site 502025011376 active site 502025011377 primary dimer interface [polypeptide binding]; other site 502025011378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011383 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 502025011384 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 502025011385 catalytic residues [active] 502025011386 AMP-binding enzyme; Region: AMP-binding; cl15778 502025011387 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011388 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 502025011389 NAD(P) binding site [chemical binding]; other site 502025011390 catalytic residues [active] 502025011391 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 502025011392 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 502025011393 active site 502025011394 catalytic residues [active] 502025011395 metal binding site [ion binding]; metal-binding site 502025011396 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 502025011397 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 502025011398 substrate binding site [chemical binding]; other site 502025011399 ligand binding site [chemical binding]; other site 502025011400 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 502025011401 substrate binding site [chemical binding]; other site 502025011402 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 502025011403 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 502025011404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025011405 active site 502025011406 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 502025011407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025011408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025011409 P-loop; other site 502025011410 Magnesium ion binding site [ion binding]; other site 502025011411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025011412 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025011413 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025011414 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025011415 putative active site pocket [active] 502025011416 dimerization interface [polypeptide binding]; other site 502025011417 putative catalytic residue [active] 502025011418 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 502025011419 lipoprotein signal peptidase; Provisional; Region: PRK14787 502025011420 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 502025011421 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 502025011422 catalytic motif [active] 502025011423 Zn binding site [ion binding]; other site 502025011424 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025011425 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025011426 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025011427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025011428 Cation efflux family; Region: Cation_efflux; cl00316 502025011429 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 502025011430 HIT family signature motif; other site 502025011431 catalytic residue [active] 502025011432 Trm112p-like protein; Region: Trm112p; cl01066 502025011433 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025011434 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025011435 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 502025011436 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 502025011437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025011438 active site 502025011439 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 502025011440 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 502025011441 5S rRNA interface [nucleotide binding]; other site 502025011442 CTC domain interface [polypeptide binding]; other site 502025011443 L16 interface [polypeptide binding]; other site 502025011444 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 502025011445 putative active site [active] 502025011446 catalytic residue [active] 502025011447 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 502025011448 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 502025011449 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 502025011450 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 502025011451 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 502025011452 replicative DNA helicase; Region: DnaB; TIGR00665 502025011453 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 502025011454 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 502025011455 Walker A motif; other site 502025011456 ATP binding site [chemical binding]; other site 502025011457 Walker B motif; other site 502025011458 DNA binding loops [nucleotide binding] 502025011459 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011461 active site 502025011462 ATP binding site [chemical binding]; other site 502025011463 substrate binding site [chemical binding]; other site 502025011464 activation loop (A-loop); other site 502025011465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011466 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 502025011467 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025011468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025011469 DNA binding residues [nucleotide binding] 502025011470 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025011471 TPR repeat; Region: TPR_11; pfam13414 502025011472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011473 binding surface 502025011474 TPR motif; other site 502025011475 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 502025011476 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 502025011477 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 502025011478 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025011479 catalytic residue [active] 502025011480 L-aspartate oxidase; Provisional; Region: PRK09077 502025011481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011482 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 502025011483 4Fe-4S binding domain; Region: Fer4; cl02805 502025011484 NADH dehydrogenase; Region: NADHdh; cl00469 502025011485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025011486 catalytic loop [active] 502025011487 iron binding site [ion binding]; other site 502025011488 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 502025011489 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 502025011490 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 502025011491 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025011492 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025011493 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 502025011494 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 502025011495 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 502025011496 NADH dehydrogenase subunit B; Provisional; Region: PRK14818 502025011497 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 502025011498 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 502025011499 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 502025011500 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025011501 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025011502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025011503 catalytic residue [active] 502025011504 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 502025011505 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025011506 Beta propeller domain; Region: Beta_propel; pfam09826 502025011507 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 502025011508 Na binding site [ion binding]; other site 502025011509 putative substrate binding site [chemical binding]; other site 502025011510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025011511 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 502025011512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 502025011513 DNA binding site [nucleotide binding] 502025011514 domain linker motif; other site 502025011515 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 502025011516 dimerization interface [polypeptide binding]; other site 502025011517 ligand binding site [chemical binding]; other site 502025011518 Biofilm formation and stress response factor; Region: BsmA; cl01794 502025011519 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 502025011520 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 502025011521 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 502025011522 xylulokinase; Provisional; Region: PRK15027 502025011523 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 502025011524 N- and C-terminal domain interface [polypeptide binding]; other site 502025011525 active site 502025011526 catalytic site [active] 502025011527 metal binding site [ion binding]; metal-binding site 502025011528 xylulose binding site [chemical binding]; other site 502025011529 putative ATP binding site [chemical binding]; other site 502025011530 homodimer interface [polypeptide binding]; other site 502025011531 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025011532 active site 502025011533 catalytic residues [active] 502025011534 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025011535 Ca binding site [ion binding]; other site 502025011536 ligand binding site I [chemical binding]; other site 502025011537 homodimer interface [polypeptide binding]; other site 502025011538 ligand binding site II [chemical binding]; other site 502025011539 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011540 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025011541 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011543 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025011544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025011545 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025011546 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025011547 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 502025011548 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 502025011549 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 502025011550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025011551 inhibitor-cofactor binding pocket; inhibition site 502025011552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011553 catalytic residue [active] 502025011554 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025011555 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011556 NAD(P) binding site [chemical binding]; other site 502025011557 catalytic residues [active] 502025011558 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 502025011559 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025011560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025011561 catalytic residue [active] 502025011562 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025011563 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025011564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025011565 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011566 phosphopeptide binding site; other site 502025011567 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025011568 GAF domain; Region: GAF; cl15785 502025011569 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025011570 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 502025011571 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 502025011572 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 502025011573 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 502025011574 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 502025011575 catalytic site [active] 502025011576 active site 502025011577 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 502025011578 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025011579 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 502025011580 active site 502025011581 catalytic site [active] 502025011582 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 502025011583 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 502025011584 putative hydrophobic ligand binding site [chemical binding]; other site 502025011585 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 502025011586 putative MPT binding site; other site 502025011587 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 502025011588 metal-binding site 502025011589 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 502025011590 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 502025011591 XdhC Rossmann domain; Region: XdhC_C; pfam13478 502025011592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025011593 dimerization interface [polypeptide binding]; other site 502025011594 putative DNA binding site [nucleotide binding]; other site 502025011595 putative Zn2+ binding site [ion binding]; other site 502025011596 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 502025011597 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 502025011598 active site 502025011599 Zn2+ binding site [ion binding]; other site 502025011600 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011601 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011602 active site 502025011603 ATP binding site [chemical binding]; other site 502025011604 substrate binding site [chemical binding]; other site 502025011605 activation loop (A-loop); other site 502025011606 HEAT repeats; Region: HEAT_2; pfam13646 502025011607 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011608 phosphopeptide binding site; other site 502025011609 GAF domain; Region: GAF_2; pfam13185 502025011610 GAF domain; Region: GAF; cl15785 502025011611 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025011612 cyclase homology domain; Region: CHD; cd07302 502025011613 nucleotidyl binding site; other site 502025011614 metal binding site [ion binding]; metal-binding site 502025011615 dimer interface [polypeptide binding]; other site 502025011616 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025011617 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025011618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011619 binding surface 502025011620 TPR motif; other site 502025011621 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025011622 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025011623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011624 TPR motif; other site 502025011625 binding surface 502025011626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011627 binding surface 502025011628 TPR motif; other site 502025011629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011630 binding surface 502025011631 TPR motif; other site 502025011632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011633 binding surface 502025011634 TPR motif; other site 502025011635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011636 binding surface 502025011637 TPR motif; other site 502025011638 Nitrogen regulatory protein P-II; Region: P-II; cl00412 502025011639 Nitrogen regulatory protein P-II; Region: P-II; smart00938 502025011640 glutamine synthetase, type I; Region: GlnA; TIGR00653 502025011641 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 502025011642 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 502025011643 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025011644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025011645 dimer interface [polypeptide binding]; other site 502025011646 phosphorylation site [posttranslational modification] 502025011647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011648 ATP binding site [chemical binding]; other site 502025011649 Mg2+ binding site [ion binding]; other site 502025011650 G-X-G motif; other site 502025011651 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011653 active site 502025011654 phosphorylation site [posttranslational modification] 502025011655 intermolecular recognition site; other site 502025011656 dimerization interface [polypeptide binding]; other site 502025011657 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 502025011658 PhoU domain; Region: PhoU; pfam01895 502025011659 PhoU domain; Region: PhoU; pfam01895 502025011660 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 502025011661 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 502025011662 Walker A/P-loop; other site 502025011663 ATP binding site [chemical binding]; other site 502025011664 Q-loop/lid; other site 502025011665 ABC transporter signature motif; other site 502025011666 Walker B; other site 502025011667 D-loop; other site 502025011668 H-loop/switch region; other site 502025011669 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 502025011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025011671 dimer interface [polypeptide binding]; other site 502025011672 conserved gate region; other site 502025011673 putative PBP binding loops; other site 502025011674 ABC-ATPase subunit interface; other site 502025011675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025011676 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 502025011677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025011678 dimer interface [polypeptide binding]; other site 502025011679 conserved gate region; other site 502025011680 putative PBP binding loops; other site 502025011681 ABC-ATPase subunit interface; other site 502025011682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025011683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025011684 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 502025011685 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 502025011686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011687 S-adenosylmethionine binding site [chemical binding]; other site 502025011688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025011689 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 502025011690 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 502025011691 Probable Catalytic site; other site 502025011692 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 502025011693 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025011694 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 502025011695 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 502025011696 PilZ domain; Region: PilZ; cl01260 502025011697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025011698 active site 502025011699 dimerization interface [polypeptide binding]; other site 502025011700 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 502025011701 ParB-like nuclease domain; Region: ParBc; cl02129 502025011702 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025011703 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025011704 P-loop; other site 502025011705 Magnesium ion binding site [ion binding]; other site 502025011706 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025011707 Magnesium ion binding site [ion binding]; other site 502025011708 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011709 phosphopeptide binding site; other site 502025011710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011711 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025011712 Walker A motif; other site 502025011713 ATP binding site [chemical binding]; other site 502025011714 Walker B motif; other site 502025011715 arginine finger; other site 502025011716 Helix-turn-helix domains; Region: HTH; cl00088 502025011717 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025011718 ligand binding site [chemical binding]; other site 502025011719 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025011720 catalytic residues [active] 502025011721 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 502025011722 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 502025011723 Two component regulator propeller; Region: Reg_prop; pfam07494 502025011724 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 502025011725 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025011726 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 502025011727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025011728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011729 homodimer interface [polypeptide binding]; other site 502025011730 catalytic residue [active] 502025011731 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06035 502025011732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011733 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025011734 enoyl-CoA hydratase; Provisional; Region: PRK07658 502025011735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025011736 substrate binding site [chemical binding]; other site 502025011737 trimer interface [polypeptide binding]; other site 502025011738 oxyanion hole (OAH) forming residues; other site 502025011739 putative acyltransferase; Provisional; Region: PRK05790 502025011740 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025011741 dimer interface [polypeptide binding]; other site 502025011742 active site 502025011743 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 502025011744 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 502025011745 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 502025011746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011747 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 502025011748 L-serine binding site [chemical binding]; other site 502025011749 ACT domain interface; other site 502025011750 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 502025011751 active site 502025011752 metal binding site [ion binding]; metal-binding site 502025011753 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025011754 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025011755 5'-3' exonuclease; Region: 53EXOc; smart00475 502025011756 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 502025011757 active site 502025011758 metal binding site 1 [ion binding]; metal-binding site 502025011759 putative 5' ssDNA interaction site; other site 502025011760 metal binding site 3; metal-binding site 502025011761 metal binding site 2 [ion binding]; metal-binding site 502025011762 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 502025011763 putative DNA binding site [nucleotide binding]; other site 502025011764 putative metal binding site [ion binding]; other site 502025011765 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 502025011766 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 502025011767 active site 502025011768 substrate binding site [chemical binding]; other site 502025011769 catalytic site [active] 502025011770 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 502025011771 active site 502025011772 DNA binding site [nucleotide binding] 502025011773 catalytic site [active] 502025011774 PilZ domain; Region: PilZ; cl01260 502025011775 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025011776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011777 TPR motif; other site 502025011778 binding surface 502025011779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011780 TPR motif; other site 502025011781 binding surface 502025011782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011783 binding surface 502025011784 TPR motif; other site 502025011785 TPR repeat; Region: TPR_11; pfam13414 502025011786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011787 binding surface 502025011788 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025011789 TPR motif; other site 502025011790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011791 TPR repeat; Region: TPR_11; pfam13414 502025011792 binding surface 502025011793 TPR motif; other site 502025011794 HEAT repeats; Region: HEAT_2; pfam13646 502025011795 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025011796 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011797 phosphopeptide binding site; other site 502025011798 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025011799 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011800 phosphopeptide binding site; other site 502025011801 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011802 phosphopeptide binding site; other site 502025011803 Transglycosylase; Region: Transgly; cl07896 502025011804 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011805 phosphopeptide binding site; other site 502025011806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011807 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025011808 Walker A motif; other site 502025011809 ATP binding site [chemical binding]; other site 502025011810 Walker B motif; other site 502025011811 arginine finger; other site 502025011812 Helix-turn-helix domains; Region: HTH; cl00088 502025011813 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011814 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011815 active site 502025011816 ATP binding site [chemical binding]; other site 502025011817 substrate binding site [chemical binding]; other site 502025011818 activation loop (A-loop); other site 502025011819 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011821 active site 502025011822 phosphorylation site [posttranslational modification] 502025011823 intermolecular recognition site; other site 502025011824 dimerization interface [polypeptide binding]; other site 502025011825 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 502025011826 cyclase homology domain; Region: CHD; cd07302 502025011827 dimer interface [polypeptide binding]; other site 502025011828 nucleotidyl binding site; other site 502025011829 metal binding site [ion binding]; metal-binding site 502025011830 Protein kinase domain; Region: Pkinase; pfam00069 502025011831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011832 active site 502025011833 ATP binding site [chemical binding]; other site 502025011834 substrate binding site [chemical binding]; other site 502025011835 activation loop (A-loop); other site 502025011836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025011837 Predicted ATPase [General function prediction only]; Region: COG3899 502025011838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025011839 GAF domain; Region: GAF; cl15785 502025011840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025011841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025011842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011843 ATP binding site [chemical binding]; other site 502025011844 Mg2+ binding site [ion binding]; other site 502025011845 G-X-G motif; other site 502025011846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025011847 TPR motif; other site 502025011848 binding surface 502025011849 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 502025011850 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 502025011851 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 502025011852 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025011853 dimer interface [polypeptide binding]; other site 502025011854 active site 502025011855 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025011856 Ligand Binding Site [chemical binding]; other site 502025011857 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025011858 Ligand Binding Site [chemical binding]; other site 502025011859 Ferredoxin [Energy production and conversion]; Region: COG1146 502025011860 4Fe-4S binding domain; Region: Fer4; cl02805 502025011861 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 502025011862 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 502025011863 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 502025011864 DNA topoisomerase I; Validated; Region: PRK06599 502025011865 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 502025011866 active site 502025011867 interdomain interaction site; other site 502025011868 putative metal-binding site [ion binding]; other site 502025011869 nucleotide binding site [chemical binding]; other site 502025011870 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 502025011871 domain I; other site 502025011872 DNA binding groove [nucleotide binding] 502025011873 phosphate binding site [ion binding]; other site 502025011874 domain II; other site 502025011875 domain III; other site 502025011876 nucleotide binding site [chemical binding]; other site 502025011877 catalytic site [active] 502025011878 domain IV; other site 502025011879 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025011880 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025011881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025011882 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 502025011883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011884 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025011885 classical (c) SDRs; Region: SDR_c; cd05233 502025011886 NAD(P) binding site [chemical binding]; other site 502025011887 active site 502025011888 CheB methylesterase; Region: CheB_methylest; pfam01339 502025011889 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025011890 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025011891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025011892 PAS domain; Region: PAS_10; pfam13596 502025011893 PAS domain S-box; Region: sensory_box; TIGR00229 502025011894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025011895 putative active site [active] 502025011896 heme pocket [chemical binding]; other site 502025011897 PAS fold; Region: PAS_4; pfam08448 502025011898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025011899 putative active site [active] 502025011900 heme pocket [chemical binding]; other site 502025011901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025011902 dimer interface [polypeptide binding]; other site 502025011903 phosphorylation site [posttranslational modification] 502025011904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011905 ATP binding site [chemical binding]; other site 502025011906 Mg2+ binding site [ion binding]; other site 502025011907 G-X-G motif; other site 502025011908 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011910 active site 502025011911 phosphorylation site [posttranslational modification] 502025011912 intermolecular recognition site; other site 502025011913 dimerization interface [polypeptide binding]; other site 502025011914 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 502025011915 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 502025011916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025011917 active site 502025011918 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 502025011919 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 502025011920 Tetratricopeptide repeat; Region: TPR_6; pfam13174 502025011921 TPR repeat; Region: TPR_11; pfam13414 502025011922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011923 binding surface 502025011924 TPR motif; other site 502025011925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025011926 TPR repeat; Region: TPR_11; pfam13414 502025011927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011928 binding surface 502025011929 TPR motif; other site 502025011930 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025011931 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025011932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025011933 dimer interface [polypeptide binding]; other site 502025011934 phosphorylation site [posttranslational modification] 502025011935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011936 ATP binding site [chemical binding]; other site 502025011937 Mg2+ binding site [ion binding]; other site 502025011938 G-X-G motif; other site 502025011939 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011941 active site 502025011942 phosphorylation site [posttranslational modification] 502025011943 intermolecular recognition site; other site 502025011944 dimerization interface [polypeptide binding]; other site 502025011945 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025011946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011947 active site 502025011948 phosphorylation site [posttranslational modification] 502025011949 intermolecular recognition site; other site 502025011950 dimerization interface [polypeptide binding]; other site 502025011951 sensory histidine kinase AtoS; Provisional; Region: PRK11360 502025011952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025011953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011954 ATP binding site [chemical binding]; other site 502025011955 Mg2+ binding site [ion binding]; other site 502025011956 G-X-G motif; other site 502025011957 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011959 active site 502025011960 phosphorylation site [posttranslational modification] 502025011961 intermolecular recognition site; other site 502025011962 Protein of unknown function, DUF399; Region: DUF399; cl01139 502025011963 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 502025011964 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 502025011965 Permutation of conserved domain; other site 502025011966 active site 502025011967 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 502025011968 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025011969 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025011970 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025011971 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025011972 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025011973 active site 502025011974 SpoVR like protein; Region: SpoVR; pfam04293 502025011975 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 502025011976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025011977 Uncharacterized conserved protein [Function unknown]; Region: COG2718 502025011978 PrkA AAA domain; Region: AAA_PrkA; smart00763 502025011979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025011980 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 502025011981 YceG-like family; Region: YceG; pfam02618 502025011982 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 502025011983 dimerization interface [polypeptide binding]; other site 502025011984 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025011985 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 502025011986 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 502025011987 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 502025011988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011989 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025011990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025011991 DNA binding residues [nucleotide binding] 502025011992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025011993 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025011994 active site 502025011995 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 502025011996 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 502025011997 HIGH motif; other site 502025011998 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 502025011999 active site 502025012000 KMSKS motif; other site 502025012001 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 502025012002 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025012003 oligomerisation interface [polypeptide binding]; other site 502025012004 mobile loop; other site 502025012005 roof hairpin; other site 502025012006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025012007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012008 active site 502025012009 phosphorylation site [posttranslational modification] 502025012010 intermolecular recognition site; other site 502025012011 dimerization interface [polypeptide binding]; other site 502025012012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025012013 DNA binding site [nucleotide binding] 502025012014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012015 dimer interface [polypeptide binding]; other site 502025012016 phosphorylation site [posttranslational modification] 502025012017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012018 ATP binding site [chemical binding]; other site 502025012019 Mg2+ binding site [ion binding]; other site 502025012020 G-X-G motif; other site 502025012021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012022 dimer interface [polypeptide binding]; other site 502025012023 phosphorylation site [posttranslational modification] 502025012024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012025 ATP binding site [chemical binding]; other site 502025012026 Mg2+ binding site [ion binding]; other site 502025012027 G-X-G motif; other site 502025012028 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025012029 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012030 P-loop; other site 502025012031 Magnesium ion binding site [ion binding]; other site 502025012032 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012033 Magnesium ion binding site [ion binding]; other site 502025012034 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 502025012035 CrcB-like protein; Region: CRCB; cl09114 502025012036 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 502025012037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012038 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025012039 AMP-binding enzyme; Region: AMP-binding; cl15778 502025012040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025012041 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 502025012042 E-class dimer interface [polypeptide binding]; other site 502025012043 P-class dimer interface [polypeptide binding]; other site 502025012044 active site 502025012045 Cu2+ binding site [ion binding]; other site 502025012046 Zn2+ binding site [ion binding]; other site 502025012047 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 502025012048 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 502025012049 putative DNA binding site [nucleotide binding]; other site 502025012050 catalytic residue [active] 502025012051 putative H2TH interface [polypeptide binding]; other site 502025012052 putative catalytic residues [active] 502025012053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 502025012054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025012055 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 502025012056 ATP binding site [chemical binding]; other site 502025012057 putative Mg++ binding site [ion binding]; other site 502025012058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025012059 nucleotide binding region [chemical binding]; other site 502025012060 ATP-binding site [chemical binding]; other site 502025012061 DEAD/H associated; Region: DEAD_assoc; pfam08494 502025012062 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025012063 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025012064 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 502025012065 putative active site [active] 502025012066 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 502025012067 active site 502025012068 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025012069 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025012070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012072 active site 502025012073 ATP binding site [chemical binding]; other site 502025012074 substrate binding site [chemical binding]; other site 502025012075 activation loop (A-loop); other site 502025012076 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 502025012077 Double zinc ribbon; Region: DZR; pfam12773 502025012078 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 502025012079 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 502025012080 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 502025012081 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 502025012082 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025012083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 502025012084 putative homodimer interface [polypeptide binding]; other site 502025012085 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 502025012086 spermidine synthase; Provisional; Region: PRK00811 502025012087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012088 S-adenosylmethionine binding site [chemical binding]; other site 502025012089 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025012090 intersubunit interface [polypeptide binding]; other site 502025012091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025012092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025012093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012094 phosphopeptide binding site; other site 502025012095 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012097 Walker A motif; other site 502025012098 ATP binding site [chemical binding]; other site 502025012099 Walker B motif; other site 502025012100 arginine finger; other site 502025012101 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 502025012102 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025012103 metal ion-dependent adhesion site (MIDAS); other site 502025012104 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025012105 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025012106 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 502025012107 Helix-turn-helix domains; Region: HTH; cl00088 502025012108 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 502025012109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012110 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 502025012111 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 502025012112 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025012113 PilZ domain; Region: PilZ; cl01260 502025012114 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 502025012115 GAF domain; Region: GAF; cl15785 502025012116 Phytochrome region; Region: PHY; pfam00360 502025012117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012118 dimer interface [polypeptide binding]; other site 502025012119 phosphorylation site [posttranslational modification] 502025012120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012121 ATP binding site [chemical binding]; other site 502025012122 Mg2+ binding site [ion binding]; other site 502025012123 G-X-G motif; other site 502025012124 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012126 active site 502025012127 phosphorylation site [posttranslational modification] 502025012128 intermolecular recognition site; other site 502025012129 dimerization interface [polypeptide binding]; other site 502025012130 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012132 active site 502025012133 phosphorylation site [posttranslational modification] 502025012134 intermolecular recognition site; other site 502025012135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012136 dimer interface [polypeptide binding]; other site 502025012137 phosphorylation site [posttranslational modification] 502025012138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012139 ATP binding site [chemical binding]; other site 502025012140 Mg2+ binding site [ion binding]; other site 502025012141 G-X-G motif; other site 502025012142 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 502025012143 heme binding pocket [chemical binding]; other site 502025012144 heme ligand [chemical binding]; other site 502025012145 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025012146 DNA binding site [nucleotide binding] 502025012147 active site 502025012148 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 502025012149 MoaE interaction surface [polypeptide binding]; other site 502025012150 MoeB interaction surface [polypeptide binding]; other site 502025012151 thiocarboxylated glycine; other site 502025012152 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 502025012153 MoaE homodimer interface [polypeptide binding]; other site 502025012154 MoaD interaction [polypeptide binding]; other site 502025012155 active site residues [active] 502025012156 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025012157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012158 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012159 Walker A motif; other site 502025012160 ATP binding site [chemical binding]; other site 502025012161 Walker B motif; other site 502025012162 arginine finger; other site 502025012163 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 502025012164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025012165 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025012166 Zn binding site [ion binding]; other site 502025012167 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025012168 putative active site [active] 502025012169 putative CoA binding site [chemical binding]; other site 502025012170 nudix motif; other site 502025012171 metal binding site [ion binding]; metal-binding site 502025012172 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 502025012173 Citrate synthase; Region: Citrate_synt; pfam00285 502025012174 oxalacetate binding site [chemical binding]; other site 502025012175 citrylCoA binding site [chemical binding]; other site 502025012176 coenzyme A binding site [chemical binding]; other site 502025012177 catalytic triad [active] 502025012178 NRDE protein; Region: NRDE; cl01315 502025012179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012180 S-adenosylmethionine binding site [chemical binding]; other site 502025012181 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025012182 catalytic triad [active] 502025012183 putative active site [active] 502025012184 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025012185 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025012186 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 502025012187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025012188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025012189 catalytic residue [active] 502025012190 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 502025012191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012192 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 502025012193 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 502025012194 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 502025012195 dimerization interface [polypeptide binding]; other site 502025012196 putative ATP binding site [chemical binding]; other site 502025012197 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025012198 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025012199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025012200 FeS/SAM binding site; other site 502025012201 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025012202 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 502025012203 putative active site [active] 502025012204 catalytic triad [active] 502025012205 putative dimer interface [polypeptide binding]; other site 502025012206 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 502025012207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025012208 GAF domain; Region: GAF; cl15785 502025012209 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025012210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012211 Walker A motif; other site 502025012212 ATP binding site [chemical binding]; other site 502025012213 Walker B motif; other site 502025012214 arginine finger; other site 502025012215 Helix-turn-helix domains; Region: HTH; cl00088 502025012216 TetR family transcriptional regulator; Provisional; Region: PRK14996 502025012217 Helix-turn-helix domains; Region: HTH; cl00088 502025012218 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025012219 dimer interface [polypeptide binding]; other site 502025012220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025012221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025012222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025012223 putative substrate translocation pore; other site 502025012224 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 502025012225 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 502025012226 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 502025012227 active site 502025012228 dimer interface [polypeptide binding]; other site 502025012229 motif 1; other site 502025012230 motif 2; other site 502025012231 motif 3; other site 502025012232 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 502025012233 anticodon binding site; other site 502025012234 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025012235 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025012236 Endonuclease I; Region: Endonuclease_1; cl01003 502025012237 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 502025012238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025012240 YCII-related domain; Region: YCII; cl00999 502025012241 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025012242 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025012243 putative di-iron ligands [ion binding]; other site 502025012244 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 502025012245 Family description; Region: VCBS; pfam13517 502025012246 Family description; Region: VCBS; pfam13517 502025012247 Family description; Region: VCBS; pfam13517 502025012248 Family description; Region: VCBS; pfam13517 502025012249 Family description; Region: VCBS; pfam13517 502025012250 Family description; Region: VCBS; pfam13517 502025012251 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025012252 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025012253 iron-sulfur cluster [ion binding]; other site 502025012254 [2Fe-2S] cluster binding site [ion binding]; other site 502025012255 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025012256 GH3 auxin-responsive promoter; Region: GH3; cl04006 502025012257 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 502025012258 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 502025012259 short chain dehydrogenase; Provisional; Region: PRK06924 502025012260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012261 NAD(P) binding site [chemical binding]; other site 502025012262 active site 502025012263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025012264 non-specific DNA binding site [nucleotide binding]; other site 502025012265 salt bridge; other site 502025012266 sequence-specific DNA binding site [nucleotide binding]; other site 502025012267 Cupin domain; Region: Cupin_2; cl09118 502025012268 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025012269 PAAR motif; Region: PAAR_motif; cl15808 502025012270 Carboxylesterase family; Region: COesterase; pfam00135 502025012271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025012272 substrate binding pocket [chemical binding]; other site 502025012273 catalytic triad [active] 502025012274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025012275 Helix-turn-helix domains; Region: HTH; cl00088 502025012276 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 502025012277 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 502025012278 NADP binding site [chemical binding]; other site 502025012279 dimer interface [polypeptide binding]; other site 502025012280 Helix-turn-helix domains; Region: HTH; cl00088 502025012281 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 502025012282 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 502025012283 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025012284 dimer interface [polypeptide binding]; other site 502025012285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025012286 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 502025012287 substrate binding site [chemical binding]; other site 502025012288 oxyanion hole (OAH) forming residues; other site 502025012289 trimer interface [polypeptide binding]; other site 502025012290 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 502025012291 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 502025012292 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 502025012293 FAD binding site [chemical binding]; other site 502025012294 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 502025012295 active site 502025012296 dimer interface [polypeptide binding]; other site 502025012297 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012298 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025012299 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025012300 active site 502025012301 catalytic residues [active] 502025012302 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012303 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012304 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012305 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012306 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025012307 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025012308 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025012309 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025012310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012311 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012312 active site 502025012313 ATP binding site [chemical binding]; other site 502025012314 substrate binding site [chemical binding]; other site 502025012315 activation loop (A-loop); other site 502025012316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012317 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025012318 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025012319 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025012320 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025012321 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025012322 structural tetrad; other site 502025012323 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025012324 structural tetrad; other site 502025012325 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 502025012326 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025012327 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025012328 protein binding site [polypeptide binding]; other site 502025012329 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025012330 protein binding site [polypeptide binding]; other site 502025012331 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012333 active site 502025012334 phosphorylation site [posttranslational modification] 502025012335 intermolecular recognition site; other site 502025012336 dimerization interface [polypeptide binding]; other site 502025012337 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025012338 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025012339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012340 Walker A motif; other site 502025012341 ATP binding site [chemical binding]; other site 502025012342 Walker B motif; other site 502025012343 arginine finger; other site 502025012344 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025012345 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025012346 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 502025012347 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025012348 fumarate hydratase; Reviewed; Region: fumC; PRK00485 502025012349 Class II fumarases; Region: Fumarase_classII; cd01362 502025012350 active site 502025012351 tetramer interface [polypeptide binding]; other site 502025012352 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 502025012353 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012354 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012355 active site 502025012356 ATP binding site [chemical binding]; other site 502025012357 substrate binding site [chemical binding]; other site 502025012358 activation loop (A-loop); other site 502025012359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012360 Predicted ATPase [General function prediction only]; Region: COG3899 502025012361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012362 TPR motif; other site 502025012363 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025012364 binding surface 502025012365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025012366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012367 binding surface 502025012368 TPR motif; other site 502025012369 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 502025012370 Histidine kinase; Region: His_kinase; pfam06580 502025012371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025012372 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 502025012373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012374 active site 502025012375 phosphorylation site [posttranslational modification] 502025012376 intermolecular recognition site; other site 502025012377 dimerization interface [polypeptide binding]; other site 502025012378 LytTr DNA-binding domain; Region: LytTR; cl04498 502025012379 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025012380 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025012381 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025012382 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025012383 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025012384 TPR repeat; Region: TPR_11; pfam13414 502025012385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025012386 binding surface 502025012387 TPR motif; other site 502025012388 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025012389 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012391 active site 502025012392 ATP binding site [chemical binding]; other site 502025012393 substrate binding site [chemical binding]; other site 502025012394 activation loop (A-loop); other site 502025012395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025012396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025012397 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012399 active site 502025012400 phosphorylation site [posttranslational modification] 502025012401 intermolecular recognition site; other site 502025012402 dimerization interface [polypeptide binding]; other site 502025012403 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 502025012404 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 502025012405 putative dimer interface [polypeptide binding]; other site 502025012406 putative anticodon binding site; other site 502025012407 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 502025012408 homodimer interface [polypeptide binding]; other site 502025012409 motif 1; other site 502025012410 motif 2; other site 502025012411 active site 502025012412 motif 3; other site 502025012413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025012414 ligand binding site [chemical binding]; other site 502025012415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012416 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012417 Walker A motif; other site 502025012418 ATP binding site [chemical binding]; other site 502025012419 Walker B motif; other site 502025012420 arginine finger; other site 502025012421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025012422 active site 502025012423 phosphorylation site [posttranslational modification] 502025012424 intermolecular recognition site; other site 502025012425 dimerization interface [polypeptide binding]; other site 502025012426 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025012427 metal ion-dependent adhesion site (MIDAS); other site 502025012428 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025012429 Ligand Binding Site [chemical binding]; other site 502025012430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025012431 Ligand Binding Site [chemical binding]; other site 502025012432 BCCT family transporter; Region: BCCT; cl00569 502025012433 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025012434 HSP70 interaction site [polypeptide binding]; other site 502025012435 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 502025012436 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025012437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025012438 FeS/SAM binding site; other site 502025012439 TRAM domain; Region: TRAM; cl01282 502025012440 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025012441 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 502025012442 amino acid transporter; Region: 2A0306; TIGR00909 502025012443 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025012444 active site 502025012445 phosphorylation site [posttranslational modification] 502025012446 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025012447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012448 putative active site [active] 502025012449 heme pocket [chemical binding]; other site 502025012450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012451 phosphorylation site [posttranslational modification] 502025012452 dimer interface [polypeptide binding]; other site 502025012453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012454 ATP binding site [chemical binding]; other site 502025012455 Mg2+ binding site [ion binding]; other site 502025012456 G-X-G motif; other site 502025012457 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 502025012458 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 502025012459 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 502025012460 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 502025012461 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 502025012462 Walker A motif; other site 502025012463 ATP binding site [chemical binding]; other site 502025012464 Walker B motif; other site 502025012465 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 502025012466 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025012467 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 502025012468 Walker A motif; other site 502025012469 ATP binding site [chemical binding]; other site 502025012470 Walker B motif; other site 502025012471 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 502025012472 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025012473 putative RNA binding site [nucleotide binding]; other site 502025012474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012475 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 502025012476 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 502025012477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025012478 Helix-turn-helix domains; Region: HTH; cl00088 502025012479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 502025012480 dimerization interface [polypeptide binding]; other site 502025012481 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 502025012482 DctM-like transporters; Region: DctM; pfam06808 502025012483 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 502025012484 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025012485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012486 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025012487 Uncharacterized conserved protein [Function unknown]; Region: COG4850 502025012488 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 502025012489 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 502025012490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012491 putative active site [active] 502025012492 PAS fold; Region: PAS_3; pfam08447 502025012493 heme pocket [chemical binding]; other site 502025012494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012495 dimer interface [polypeptide binding]; other site 502025012496 phosphorylation site [posttranslational modification] 502025012497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012498 ATP binding site [chemical binding]; other site 502025012499 Mg2+ binding site [ion binding]; other site 502025012500 G-X-G motif; other site 502025012501 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012503 active site 502025012504 phosphorylation site [posttranslational modification] 502025012505 intermolecular recognition site; other site 502025012506 dimerization interface [polypeptide binding]; other site 502025012507 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 502025012508 MltA specific insert domain; Region: MltA; cl08398 502025012509 3D domain; Region: 3D; cl01439 502025012510 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025012511 Helix-turn-helix domains; Region: HTH; cl00088 502025012512 WYL domain; Region: WYL; cl14852 502025012513 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 502025012514 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 502025012515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012517 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025012518 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 502025012519 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 502025012520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012521 Walker A motif; other site 502025012522 ATP binding site [chemical binding]; other site 502025012523 Walker B motif; other site 502025012524 Integrase core domain; Region: rve; cl01316 502025012525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012526 Walker A motif; other site 502025012527 ATP binding site [chemical binding]; other site 502025012528 Walker B motif; other site 502025012529 Integrase core domain; Region: rve; cl01316 502025012530 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 502025012531 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 502025012532 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 502025012533 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025012534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012535 putative active site [active] 502025012536 heme pocket [chemical binding]; other site 502025012537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012538 dimer interface [polypeptide binding]; other site 502025012539 phosphorylation site [posttranslational modification] 502025012540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012541 ATP binding site [chemical binding]; other site 502025012542 Mg2+ binding site [ion binding]; other site 502025012543 G-X-G motif; other site 502025012544 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 502025012545 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 502025012546 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025012547 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025012548 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025012549 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025012550 Protein export membrane protein; Region: SecD_SecF; cl14618 502025012551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012552 S-adenosylmethionine binding site [chemical binding]; other site 502025012553 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 502025012554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012555 Helix-turn-helix domains; Region: HTH; cl00088 502025012556 DNA binding site [nucleotide binding] 502025012557 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 502025012558 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025012559 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025012560 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025012561 PilZ domain; Region: PilZ; cl01260 502025012562 SurA N-terminal domain; Region: SurA_N_3; cl07813 502025012563 PPIC-type PPIASE domain; Region: Rotamase; cl08278 502025012564 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 502025012565 PPIC-type PPIASE domain; Region: Rotamase; cl08278 502025012566 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 502025012567 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 502025012568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025012569 ATP binding site [chemical binding]; other site 502025012570 putative Mg++ binding site [ion binding]; other site 502025012571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025012572 nucleotide binding region [chemical binding]; other site 502025012573 ATP-binding site [chemical binding]; other site 502025012574 TRCF domain; Region: TRCF; cl04088 502025012575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012576 active site 502025012577 ATP binding site [chemical binding]; other site 502025012578 substrate binding site [chemical binding]; other site 502025012579 activation loop (A-loop); other site 502025012580 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 502025012581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012582 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 502025012583 Family description; Region: UvrD_C_2; cl15862 502025012584 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 502025012585 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 502025012586 AMP-binding enzyme; Region: AMP-binding; cl15778 502025012587 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012588 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 502025012589 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 502025012590 putative active site [active] 502025012591 catalytic site [active] 502025012592 putative metal binding site [ion binding]; other site 502025012593 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025012594 homotrimer interaction site [polypeptide binding]; other site 502025012595 putative active site [active] 502025012596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025012597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025012598 active site 502025012599 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025012600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025012601 substrate binding site [chemical binding]; other site 502025012602 oxyanion hole (OAH) forming residues; other site 502025012603 trimer interface [polypeptide binding]; other site 502025012604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025012605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012606 NAD(P) binding site [chemical binding]; other site 502025012607 active site 502025012608 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 502025012609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012610 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 502025012611 active site 502025012612 FMN binding site [chemical binding]; other site 502025012613 substrate binding site [chemical binding]; other site 502025012614 homotetramer interface [polypeptide binding]; other site 502025012615 catalytic residue [active] 502025012616 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 502025012617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025012618 FAD binding site [chemical binding]; other site 502025012619 substrate binding pocket [chemical binding]; other site 502025012620 catalytic base [active] 502025012621 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025012622 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025012623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012625 DNA binding residues [nucleotide binding] 502025012626 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 502025012627 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025012628 Phosphoesterase family; Region: Phosphoesterase; cl15450 502025012629 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025012630 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025012631 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 502025012632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025012633 ligand binding site [chemical binding]; other site 502025012634 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 502025012635 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 502025012636 TIGR01777 family protein; Region: yfcH 502025012637 putative NAD(P) binding site [chemical binding]; other site 502025012638 putative active site [active] 502025012639 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 502025012640 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012641 active site 502025012642 ATP binding site [chemical binding]; other site 502025012643 substrate binding site [chemical binding]; other site 502025012644 activation loop (A-loop); other site 502025012645 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012646 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012647 active site 502025012648 ATP binding site [chemical binding]; other site 502025012649 substrate binding site [chemical binding]; other site 502025012650 activation loop (A-loop); other site 502025012651 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 502025012652 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 502025012653 NAD binding site [chemical binding]; other site 502025012654 homotetramer interface [polypeptide binding]; other site 502025012655 homodimer interface [polypeptide binding]; other site 502025012656 substrate binding site [chemical binding]; other site 502025012657 active site 502025012658 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025012659 Integral membrane protein TerC family; Region: TerC; cl10468 502025012660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025012661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025012662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025012663 active site 502025012664 catalytic tetrad [active] 502025012665 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025012666 DNA binding residues [nucleotide binding] 502025012667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012668 DNA binding residues [nucleotide binding] 502025012669 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012670 phosphopeptide binding site; other site 502025012671 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 502025012672 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 502025012673 purine monophosphate binding site [chemical binding]; other site 502025012674 dimer interface [polypeptide binding]; other site 502025012675 putative catalytic residues [active] 502025012676 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 502025012677 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 502025012678 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 502025012679 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 502025012680 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025012681 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 502025012682 AIR carboxylase; Region: AIRC; cl00310 502025012683 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 502025012684 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 502025012685 Flagellin N-methylase; Region: FliB; cl00497 502025012686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 502025012687 DNA-binding site [nucleotide binding]; DNA binding site 502025012688 RNA-binding motif; other site 502025012689 Stage II sporulation protein; Region: SpoIID; pfam08486 502025012690 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 502025012691 CAAX protease self-immunity; Region: Abi; cl00558 502025012692 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025012693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012695 DNA binding residues [nucleotide binding] 502025012696 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025012697 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 502025012698 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 502025012699 active site 502025012700 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 502025012701 DNA binding site [nucleotide binding] 502025012702 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 502025012703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012704 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 502025012705 nucleotide binding site [chemical binding]; other site 502025012706 N-acetyl-L-glutamate binding site [chemical binding]; other site 502025012707 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 502025012708 TM2 domain; Region: TM2; cl00984 502025012709 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025012710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012712 DNA binding residues [nucleotide binding] 502025012713 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025012714 aldehyde dehydrogenase; Provisional; Region: PRK11903 502025012715 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025012716 NAD(P) binding site [chemical binding]; other site 502025012717 catalytic residues [active] 502025012718 aspartate kinase; Reviewed; Region: PRK06635 502025012719 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 502025012720 putative nucleotide binding site [chemical binding]; other site 502025012721 putative catalytic residues [active] 502025012722 putative Mg ion binding site [ion binding]; other site 502025012723 putative aspartate binding site [chemical binding]; other site 502025012724 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 502025012725 putative allosteric regulatory site; other site 502025012726 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 502025012727 putative allosteric regulatory residue; other site 502025012728 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025012729 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025012730 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012732 active site 502025012733 phosphorylation site [posttranslational modification] 502025012734 intermolecular recognition site; other site 502025012735 dimerization interface [polypeptide binding]; other site 502025012736 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025012737 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025012738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025012739 RNA binding surface [nucleotide binding]; other site 502025012740 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025012741 active site 502025012742 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 502025012743 tandem repeat interface [polypeptide binding]; other site 502025012744 oligomer interface [polypeptide binding]; other site 502025012745 active site residues [active] 502025012746 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 502025012747 tandem repeat interface [polypeptide binding]; other site 502025012748 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 502025012749 oligomer interface [polypeptide binding]; other site 502025012750 active site residues [active] 502025012751 GTP-binding protein YchF; Reviewed; Region: PRK09601 502025012752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012753 G1 box; other site 502025012754 GTP/Mg2+ binding site [chemical binding]; other site 502025012755 G2 box; other site 502025012756 Switch I region; other site 502025012757 G3 box; other site 502025012758 Switch II region; other site 502025012759 G4 box; other site 502025012760 G5 box; other site 502025012761 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 502025012762 SCP-2 sterol transfer family; Region: SCP2; cl01225 502025012763 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025012764 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012765 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012766 active site 502025012767 ATP binding site [chemical binding]; other site 502025012768 substrate binding site [chemical binding]; other site 502025012769 activation loop (A-loop); other site 502025012770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012772 active site 502025012773 ATP binding site [chemical binding]; other site 502025012774 substrate binding site [chemical binding]; other site 502025012775 activation loop (A-loop); other site 502025012776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012777 TPR motif; other site 502025012778 TPR repeat; Region: TPR_11; pfam13414 502025012779 binding surface 502025012780 ribonuclease R; Region: RNase_R; TIGR02063 502025012781 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025012782 RNB domain; Region: RNB; pfam00773 502025012783 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 502025012784 RNA binding site [nucleotide binding]; other site 502025012785 FOG: WD40-like repeat [Function unknown]; Region: COG1520 502025012786 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025012787 Trp docking motif [polypeptide binding]; other site 502025012788 active site 502025012789 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025012790 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025012791 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 502025012792 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 502025012793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012794 aspartate aminotransferase; Provisional; Region: PRK05764 502025012795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025012796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025012797 homodimer interface [polypeptide binding]; other site 502025012798 catalytic residue [active] 502025012799 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 502025012800 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 502025012801 active site 502025012802 (T/H)XGH motif; other site 502025012803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012804 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 502025012805 AMP-binding enzyme; Region: AMP-binding; cl15778 502025012806 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025012808 Helix-turn-helix domains; Region: HTH; cl00088 502025012809 photolyase PhrII; Region: phr2; TIGR00591 502025012810 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 502025012811 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025012812 dimer interface [polypeptide binding]; other site 502025012813 putative CheW interface [polypeptide binding]; other site 502025012814 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012815 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012816 active site 502025012817 ATP binding site [chemical binding]; other site 502025012818 substrate binding site [chemical binding]; other site 502025012819 activation loop (A-loop); other site 502025012820 cyclase homology domain; Region: CHD; cd07302 502025012821 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 502025012822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025012823 ATP binding site [chemical binding]; other site 502025012824 putative Mg++ binding site [ion binding]; other site 502025012825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025012826 nucleotide binding region [chemical binding]; other site 502025012827 ATP-binding site [chemical binding]; other site 502025012828 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025012829 TPR repeat; Region: TPR_11; pfam13414 502025012830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012831 binding surface 502025012832 TPR motif; other site 502025012833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012834 TPR repeat; Region: TPR_11; pfam13414 502025012835 binding surface 502025012836 TPR motif; other site 502025012837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012838 TPR motif; other site 502025012839 binding surface 502025012840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012841 TPR motif; other site 502025012842 binding surface 502025012843 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 502025012844 putative trimer interface [polypeptide binding]; other site 502025012845 putative CoA binding site [chemical binding]; other site 502025012846 trigger factor; Region: tig; TIGR00115 502025012847 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 502025012848 Clp protease; Region: CLP_protease; pfam00574 502025012849 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 502025012850 oligomer interface [polypeptide binding]; other site 502025012851 active site residues [active] 502025012852 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 502025012853 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 502025012854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012855 Walker A motif; other site 502025012856 ATP binding site [chemical binding]; other site 502025012857 Walker B motif; other site 502025012858 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025012859 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025012860 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025012861 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025012862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012863 Walker A motif; other site 502025012864 ATP binding site [chemical binding]; other site 502025012865 Walker B motif; other site 502025012866 arginine finger; other site 502025012867 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025012868 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012869 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012870 active site 502025012871 ATP binding site [chemical binding]; other site 502025012872 substrate binding site [chemical binding]; other site 502025012873 activation loop (A-loop); other site 502025012874 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025012875 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025012876 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 502025012877 muropeptide transporter; Validated; Region: ampG; PRK11010 502025012878 AmpG-like permease; Region: 2A0125; TIGR00901 502025012879 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 502025012880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025012881 Walker A/P-loop; other site 502025012882 ATP binding site [chemical binding]; other site 502025012883 AAA domain; Region: AAA_21; pfam13304 502025012884 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 502025012885 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 502025012886 TPP-binding site [chemical binding]; other site 502025012887 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 502025012888 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 502025012889 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025012890 E3 interaction surface; other site 502025012891 lipoyl attachment site [posttranslational modification]; other site 502025012892 e3 binding domain; Region: E3_binding; pfam02817 502025012893 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 502025012894 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 502025012895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025012897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025012898 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 502025012899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012900 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025012901 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 502025012902 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025012903 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025012904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012905 NAD(P) binding site [chemical binding]; other site 502025012906 active site 502025012907 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 502025012908 Clp amino terminal domain; Region: Clp_N; pfam02861 502025012909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012910 Walker A motif; other site 502025012911 ATP binding site [chemical binding]; other site 502025012912 Walker B motif; other site 502025012913 arginine finger; other site 502025012914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012915 Walker A motif; other site 502025012916 ATP binding site [chemical binding]; other site 502025012917 Walker B motif; other site 502025012918 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025012919 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 502025012920 OPT oligopeptide transporter protein; Region: OPT; cl14607 502025012921 hypothetical protein; Provisional; Region: PRK07907 502025012922 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 502025012923 metal binding site [ion binding]; metal-binding site 502025012924 putative dimer interface [polypeptide binding]; other site 502025012925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025012926 Ligand Binding Site [chemical binding]; other site 502025012927 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025012928 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 502025012929 HsdM N-terminal domain; Region: HsdM_N; pfam12161 502025012930 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 502025012931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025012932 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025012933 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025012934 Zn binding site [ion binding]; other site 502025012935 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 502025012936 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 502025012937 dimer interface [polypeptide binding]; other site 502025012938 motif 1; other site 502025012939 active site 502025012940 motif 2; other site 502025012941 motif 3; other site 502025012942 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 502025012943 anticodon binding site; other site 502025012944 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025012945 IHF - DNA interface [nucleotide binding]; other site 502025012946 IHF dimer interface [polypeptide binding]; other site 502025012947 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 502025012948 Fe-S cluster binding site [ion binding]; other site 502025012949 active site 502025012950 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 502025012951 Flavoprotein; Region: Flavoprotein; cl08021 502025012952 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 502025012953 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025012954 putative acyl-acceptor binding pocket; other site 502025012955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025012956 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025012957 putative NAD(P) binding site [chemical binding]; other site 502025012958 active site 502025012959 putative substrate binding site [chemical binding]; other site 502025012960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025012961 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 502025012962 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012964 Walker A motif; other site 502025012965 ATP binding site [chemical binding]; other site 502025012966 Walker B motif; other site 502025012967 arginine finger; other site 502025012968 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025012969 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025012970 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 502025012971 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 502025012972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025012973 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025012974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025012975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025012976 dimer interface [polypeptide binding]; other site 502025012977 phosphorylation site [posttranslational modification] 502025012978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012979 ATP binding site [chemical binding]; other site 502025012980 G-X-G motif; other site 502025012981 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025012983 active site 502025012984 phosphorylation site [posttranslational modification] 502025012985 intermolecular recognition site; other site 502025012986 dimerization interface [polypeptide binding]; other site 502025012987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025012988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012989 NAD(P) binding site [chemical binding]; other site 502025012990 active site 502025012991 Lamin Tail Domain; Region: LTD; pfam00932 502025012992 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 502025012993 Lamin Tail Domain; Region: LTD; pfam00932 502025012994 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 502025012995 generic binding surface I; other site 502025012996 generic binding surface II; other site 502025012997 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 502025012998 putative active site [active] 502025012999 putative catalytic site [active] 502025013000 putative Mg binding site IVb [ion binding]; other site 502025013001 putative phosphate binding site [ion binding]; other site 502025013002 putative DNA binding site [nucleotide binding]; other site 502025013003 putative Mg binding site IVa [ion binding]; other site 502025013004 BolA-like protein; Region: BolA; cl00386 502025013005 GTPase RsgA; Reviewed; Region: PRK01889 502025013006 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025013007 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 502025013008 GTPase/Zn-binding domain interface [polypeptide binding]; other site 502025013009 GTP/Mg2+ binding site [chemical binding]; other site 502025013010 G4 box; other site 502025013011 G5 box; other site 502025013012 G1 box; other site 502025013013 Switch I region; other site 502025013014 G2 box; other site 502025013015 G3 box; other site 502025013016 Switch II region; other site 502025013017 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 502025013018 MatE; Region: MatE; cl10513 502025013019 MatE; Region: MatE; cl10513 502025013020 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 502025013021 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 502025013022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013023 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025013024 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 502025013025 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025013026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025013027 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025013028 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 502025013029 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025013030 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 502025013031 metal binding site [ion binding]; metal-binding site 502025013032 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025013033 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 502025013034 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 502025013035 NADP binding site [chemical binding]; other site 502025013036 dimer interface [polypeptide binding]; other site 502025013037 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 502025013038 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025013039 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025013040 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 502025013041 Cytochrome c; Region: Cytochrom_C; cl11414 502025013042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013043 active site 502025013044 ATP binding site [chemical binding]; other site 502025013045 substrate binding site [chemical binding]; other site 502025013046 activation loop (A-loop); other site 502025013047 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 502025013048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025013049 active site 502025013050 Cupin domain; Region: Cupin_2; cl09118 502025013051 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 502025013052 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 502025013053 active site 502025013054 substrate binding site [chemical binding]; other site 502025013055 metal binding site [ion binding]; metal-binding site 502025013056 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 502025013057 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025013058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013059 Walker A motif; other site 502025013060 ATP binding site [chemical binding]; other site 502025013061 Walker B motif; other site 502025013062 arginine finger; other site 502025013063 Helix-turn-helix domains; Region: HTH; cl00088 502025013064 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 502025013065 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 502025013066 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025013067 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013069 active site 502025013070 phosphorylation site [posttranslational modification] 502025013071 intermolecular recognition site; other site 502025013072 dimerization interface [polypeptide binding]; other site 502025013073 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 502025013074 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 502025013075 active site 502025013076 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013077 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025013078 classical (c) SDRs; Region: SDR_c; cd05233 502025013079 NAD(P) binding site [chemical binding]; other site 502025013080 active site 502025013081 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 502025013082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025013083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025013084 active site 502025013085 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 502025013086 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 502025013087 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 502025013088 active site 502025013089 Zn binding site [ion binding]; other site 502025013090 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 502025013091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025013092 active site 502025013093 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025013094 active site 502025013095 Zn binding site [ion binding]; other site 502025013096 Protein required for attachment to host cells; Region: Host_attach; cl02398 502025013097 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 502025013098 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 502025013099 GIY-YIG motif/motif A; other site 502025013100 active site 502025013101 catalytic site [active] 502025013102 putative DNA binding site [nucleotide binding]; other site 502025013103 metal binding site [ion binding]; metal-binding site 502025013104 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 502025013105 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 502025013106 RIP metalloprotease RseP; Region: TIGR00054 502025013107 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025013108 active site 502025013109 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025013110 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 502025013111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025013112 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025013113 Ligand binding site; other site 502025013114 Putative Catalytic site; other site 502025013115 DXD motif; other site 502025013116 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 502025013117 dimer interface [polypeptide binding]; other site 502025013118 ssDNA binding site [nucleotide binding]; other site 502025013119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 502025013120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 502025013121 NodB motif; other site 502025013122 active site 502025013123 catalytic site [active] 502025013124 metal binding site [ion binding]; metal-binding site 502025013125 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025013126 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 502025013127 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025013128 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 502025013129 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025013130 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 502025013131 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025013132 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 502025013133 C-terminal domain interface [polypeptide binding]; other site 502025013134 GSH binding site (G-site) [chemical binding]; other site 502025013135 dimer interface [polypeptide binding]; other site 502025013136 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025013137 substrate binding pocket (H-site) [chemical binding]; other site 502025013138 N-terminal domain interface [polypeptide binding]; other site 502025013139 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025013140 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025013141 FG-GAP repeat; Region: FG-GAP; cl15299 502025013142 FG-GAP repeat; Region: FG-GAP; cl15299 502025013143 FG-GAP repeat; Region: FG-GAP; cl15299 502025013144 FG-GAP repeat; Region: FG-GAP; cl15299 502025013145 FG-GAP repeat; Region: FG-GAP; cl15299 502025013146 PAS domain; Region: PAS_9; pfam13426 502025013147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013148 putative active site [active] 502025013149 heme pocket [chemical binding]; other site 502025013150 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 502025013151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013152 dimer interface [polypeptide binding]; other site 502025013153 phosphorylation site [posttranslational modification] 502025013154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013155 ATP binding site [chemical binding]; other site 502025013156 Mg2+ binding site [ion binding]; other site 502025013157 G-X-G motif; other site 502025013158 tellurium resistance terB-like protein; Region: terB_like; cl11965 502025013159 metal binding site [ion binding]; metal-binding site 502025013160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013161 Walker A motif; other site 502025013162 ATP binding site [chemical binding]; other site 502025013163 Walker B motif; other site 502025013164 arginine finger; other site 502025013165 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 502025013166 NMT1-like family; Region: NMT1_2; cl15260 502025013167 NMT1/THI5 like; Region: NMT1; pfam09084 502025013168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013169 ligand binding site [chemical binding]; other site 502025013170 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 502025013171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025013172 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 502025013173 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 502025013174 Walker A/P-loop; other site 502025013175 ATP binding site [chemical binding]; other site 502025013176 Q-loop/lid; other site 502025013177 ABC transporter signature motif; other site 502025013178 Walker B; other site 502025013179 D-loop; other site 502025013180 H-loop/switch region; other site 502025013181 Protein of unknown function (DUF419); Region: DUF419; cl15265 502025013182 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 502025013183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025013185 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025013186 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 502025013187 AMP-binding enzyme; Region: AMP-binding; cl15778 502025013188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013189 Creatinine amidohydrolase; Region: Creatininase; cl00618 502025013190 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 502025013191 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025013192 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 502025013193 Cation transport protein; Region: TrkH; cl10514 502025013194 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 502025013195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013197 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025013198 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 502025013199 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025013200 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 502025013201 putative dimer interface [polypeptide binding]; other site 502025013202 N-terminal domain interface [polypeptide binding]; other site 502025013203 putative substrate binding pocket (H-site) [chemical binding]; other site 502025013204 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 502025013205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025013206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025013207 catalytic residue [active] 502025013208 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025013209 Cysteine-rich domain; Region: CCG; pfam02754 502025013210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013211 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013212 active site 502025013213 ATP binding site [chemical binding]; other site 502025013214 substrate binding site [chemical binding]; other site 502025013215 activation loop (A-loop); other site 502025013216 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013217 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013218 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013219 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013221 active site 502025013222 ATP binding site [chemical binding]; other site 502025013223 substrate binding site [chemical binding]; other site 502025013224 activation loop (A-loop); other site 502025013225 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013226 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013228 TPR motif; other site 502025013229 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 502025013230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025013231 active site 502025013232 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025013233 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025013234 phosphopeptide binding site; other site 502025013235 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 502025013236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013237 Walker A motif; other site 502025013238 ATP binding site [chemical binding]; other site 502025013239 Walker B motif; other site 502025013240 arginine finger; other site 502025013241 Helix-turn-helix domains; Region: HTH; cl00088 502025013242 TPR repeat; Region: TPR_11; pfam13414 502025013243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013244 binding surface 502025013245 TPR motif; other site 502025013246 TPR repeat; Region: TPR_11; pfam13414 502025013247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013248 binding surface 502025013249 TPR motif; other site 502025013250 TPR repeat; Region: TPR_11; pfam13414 502025013251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013253 binding surface 502025013254 TPR motif; other site 502025013255 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 502025013256 putative catalytic residues [active] 502025013257 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 502025013258 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 502025013259 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025013260 muropeptide transporter; Validated; Region: ampG; PRK11010 502025013261 AmpG-like permease; Region: 2A0125; TIGR00901 502025013262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025013263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025013264 Ligand Binding Site [chemical binding]; other site 502025013265 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013266 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 502025013267 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025013268 N-terminal plug; other site 502025013269 ligand-binding site [chemical binding]; other site 502025013270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013271 dimer interface [polypeptide binding]; other site 502025013272 phosphorylation site [posttranslational modification] 502025013273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013274 ATP binding site [chemical binding]; other site 502025013275 Mg2+ binding site [ion binding]; other site 502025013276 G-X-G motif; other site 502025013277 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013279 active site 502025013280 phosphorylation site [posttranslational modification] 502025013281 intermolecular recognition site; other site 502025013282 dimerization interface [polypeptide binding]; other site 502025013283 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 502025013284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013285 dimer interface [polypeptide binding]; other site 502025013286 phosphorylation site [posttranslational modification] 502025013287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013288 ATP binding site [chemical binding]; other site 502025013289 Mg2+ binding site [ion binding]; other site 502025013290 G-X-G motif; other site 502025013291 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 502025013292 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 502025013293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 502025013294 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668 502025013295 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025013296 metal ion-dependent adhesion site (MIDAS); other site 502025013297 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 502025013298 PilZ domain; Region: PilZ; cl01260 502025013299 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013300 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013301 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025013302 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025013303 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025013304 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 502025013305 catalytic triad [active] 502025013306 dimer interface [polypeptide binding]; other site 502025013307 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 502025013308 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 502025013309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025013310 catalytic residue [active] 502025013311 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 502025013312 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 502025013313 substrate binding site [chemical binding]; other site 502025013314 active site 502025013315 catalytic residues [active] 502025013316 heterodimer interface [polypeptide binding]; other site 502025013317 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 502025013318 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 502025013319 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013320 ligand binding site [chemical binding]; other site 502025013321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025013322 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025013323 active site 502025013324 catalytic tetrad [active] 502025013325 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025013326 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 502025013327 putative NAD(P) binding site [chemical binding]; other site 502025013328 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 502025013329 ArsC family; Region: ArsC; pfam03960 502025013330 putative ArsC-like catalytic residues; other site 502025013331 putative TRX-like catalytic residues [active] 502025013332 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 502025013333 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025013334 Family description; Region: UvrD_C_2; cl15862 502025013335 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 502025013336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025013337 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 502025013338 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 502025013339 dimerization interface 3.5A [polypeptide binding]; other site 502025013340 active site 502025013341 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 502025013342 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013344 active site 502025013345 phosphorylation site [posttranslational modification] 502025013346 intermolecular recognition site; other site 502025013347 dimerization interface [polypeptide binding]; other site 502025013348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013349 dimer interface [polypeptide binding]; other site 502025013350 phosphorylation site [posttranslational modification] 502025013351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013352 ATP binding site [chemical binding]; other site 502025013353 Mg2+ binding site [ion binding]; other site 502025013354 G-X-G motif; other site 502025013355 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013357 active site 502025013358 phosphorylation site [posttranslational modification] 502025013359 intermolecular recognition site; other site 502025013360 dimerization interface [polypeptide binding]; other site 502025013361 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025013362 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025013363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025013364 catalytic residue [active] 502025013365 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 502025013366 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 502025013367 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025013368 CoA-ligase; Region: Ligase_CoA; cl02894 502025013369 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 502025013370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013371 CoA-ligase; Region: Ligase_CoA; cl02894 502025013372 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 502025013373 active site 502025013374 multimer interface [polypeptide binding]; other site 502025013375 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 502025013376 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 502025013377 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025013378 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 502025013379 active site 502025013380 catalytic site [active] 502025013381 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 502025013382 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 502025013383 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 502025013384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025013385 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 502025013386 trimer interface; other site 502025013387 sugar binding site [chemical binding]; other site 502025013388 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 502025013389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025013390 dimer interface [polypeptide binding]; other site 502025013391 conserved gate region; other site 502025013392 putative PBP binding loops; other site 502025013393 ABC-ATPase subunit interface; other site 502025013394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025013395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025013396 dimer interface [polypeptide binding]; other site 502025013397 conserved gate region; other site 502025013398 putative PBP binding loops; other site 502025013399 ABC-ATPase subunit interface; other site 502025013400 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 502025013401 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 502025013402 Walker A/P-loop; other site 502025013403 ATP binding site [chemical binding]; other site 502025013404 Q-loop/lid; other site 502025013405 ABC transporter signature motif; other site 502025013406 Walker B; other site 502025013407 D-loop; other site 502025013408 H-loop/switch region; other site 502025013409 TOBE domain; Region: TOBE_2; cl01440 502025013410 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025013411 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025013412 active site 502025013413 catalytic site [active] 502025013414 alpha-amylase; Reviewed; Region: malS; PRK09505 502025013415 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 502025013416 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013418 active site 502025013419 phosphorylation site [posttranslational modification] 502025013420 intermolecular recognition site; other site 502025013421 dimerization interface [polypeptide binding]; other site 502025013422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025013423 non-specific DNA binding site [nucleotide binding]; other site 502025013424 salt bridge; other site 502025013425 sequence-specific DNA binding site [nucleotide binding]; other site 502025013426 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 502025013427 4Fe-4S binding domain; Region: Fer4; cl02805 502025013428 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013430 active site 502025013431 phosphorylation site [posttranslational modification] 502025013432 intermolecular recognition site; other site 502025013433 dimerization interface [polypeptide binding]; other site 502025013434 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025013435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013436 ATP binding site [chemical binding]; other site 502025013437 G-X-G motif; other site 502025013438 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013440 active site 502025013441 phosphorylation site [posttranslational modification] 502025013442 intermolecular recognition site; other site 502025013443 dimerization interface [polypeptide binding]; other site 502025013444 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 502025013445 Amidinotransferase; Region: Amidinotransf; cl12043 502025013446 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025013447 classical (c) SDRs; Region: SDR_c; cd05233 502025013448 NAD(P) binding site [chemical binding]; other site 502025013449 active site 502025013450 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025013451 catalytic residues [active] 502025013452 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 502025013453 5'-3' exonuclease; Region: 53EXOc; smart00475 502025013454 active site 502025013455 metal binding site 1 [ion binding]; metal-binding site 502025013456 putative 5' ssDNA interaction site; other site 502025013457 metal binding site 3; metal-binding site 502025013458 metal binding site 2 [ion binding]; metal-binding site 502025013459 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 502025013460 putative DNA binding site [nucleotide binding]; other site 502025013461 putative metal binding site [ion binding]; other site 502025013462 Predicted esterase [General function prediction only]; Region: COG0400 502025013463 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025013464 Surface antigen; Region: Bac_surface_Ag; cl03097 502025013465 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 502025013466 heme-binding site [chemical binding]; other site 502025013467 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 502025013468 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 502025013469 NAD(P) binding site [chemical binding]; other site 502025013470 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025013471 active site 502025013472 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025013473 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025013474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025013475 active site 502025013476 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025013477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025013478 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025013479 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 502025013480 catalytic site [active] 502025013481 putative active site [active] 502025013482 putative substrate binding site [chemical binding]; other site 502025013483 dimer interface [polypeptide binding]; other site 502025013484 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025013485 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 502025013486 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 502025013487 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025013488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013489 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 502025013490 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 502025013491 active site 2 [active] 502025013492 active site 1 [active] 502025013493 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025013494 PHB binding site; other site 502025013495 CoenzymeA binding site [chemical binding]; other site 502025013496 subunit interaction site [polypeptide binding]; other site 502025013497 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 502025013498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013500 active site 502025013501 ATP binding site [chemical binding]; other site 502025013502 substrate binding site [chemical binding]; other site 502025013503 activation loop (A-loop); other site 502025013504 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 502025013505 Cytochrome c; Region: Cytochrom_C; cl11414 502025013506 enoyl-CoA hydratase; Provisional; Region: PRK06688 502025013507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025013508 substrate binding site [chemical binding]; other site 502025013509 oxyanion hole (OAH) forming residues; other site 502025013510 trimer interface [polypeptide binding]; other site 502025013511 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025013512 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 502025013513 metal-binding site 502025013514 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 502025013515 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 502025013516 XdhC Rossmann domain; Region: XdhC_C; pfam13478 502025013517 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 502025013518 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025013519 active site 502025013520 motif I; other site 502025013521 motif II; other site 502025013522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025013523 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 502025013524 NADP binding site [chemical binding]; other site 502025013525 homodimer interface [polypeptide binding]; other site 502025013526 active site 502025013527 substrate binding site [chemical binding]; other site 502025013528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025013529 Helix-turn-helix domains; Region: HTH; cl00088 502025013530 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 502025013531 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 502025013532 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025013533 active site 502025013534 Zn binding site [ion binding]; other site 502025013535 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 502025013536 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 502025013537 Walker A/P-loop; other site 502025013538 ATP binding site [chemical binding]; other site 502025013539 Q-loop/lid; other site 502025013540 ABC transporter signature motif; other site 502025013541 Walker B; other site 502025013542 D-loop; other site 502025013543 H-loop/switch region; other site 502025013544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025013545 dimer interface [polypeptide binding]; other site 502025013546 conserved gate region; other site 502025013547 putative PBP binding loops; other site 502025013548 ABC-ATPase subunit interface; other site 502025013549 NMT1-like family; Region: NMT1_2; cl15260 502025013550 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 502025013551 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 502025013552 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025013553 Double zinc ribbon; Region: DZR; pfam12773 502025013554 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 502025013555 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 502025013556 active site 502025013557 DNA binding site [nucleotide binding] 502025013558 Int/Topo IB signature motif; other site 502025013559 catalytic residues [active] 502025013560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013561 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 502025013562 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 502025013563 NAD binding site [chemical binding]; other site 502025013564 substrate binding site [chemical binding]; other site 502025013565 homodimer interface [polypeptide binding]; other site 502025013566 active site 502025013567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013568 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 502025013569 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 502025013570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013571 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 502025013572 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 502025013573 nucleotide binding site [chemical binding]; other site 502025013574 SulA interaction site; other site 502025013575 cell division protein FtsA; Region: ftsA; TIGR01174 502025013576 Cell division protein FtsA; Region: FtsA; cl11496 502025013577 Cell division protein FtsA; Region: FtsA; cl11496 502025013578 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 502025013579 cell division protein FtsQ; Provisional; Region: PRK10775 502025013580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013581 active site 502025013582 phosphorylation site [posttranslational modification] 502025013583 intermolecular recognition site; other site 502025013584 Quinolinate synthetase A protein; Region: NadA; cl00420 502025013585 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 502025013586 ThiC-associated domain; Region: ThiC-associated; pfam13667 502025013587 ThiC family; Region: ThiC; cl08031 502025013588 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 502025013589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025013590 substrate binding site [chemical binding]; other site 502025013591 oxyanion hole (OAH) forming residues; other site 502025013592 trimer interface [polypeptide binding]; other site 502025013593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 502025013594 substrate binding site [chemical binding]; other site 502025013595 oxyanion hole (OAH) forming residues; other site 502025013596 trimer interface [polypeptide binding]; other site 502025013597 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 502025013598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013599 ligand binding site [chemical binding]; other site 502025013600 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025013601 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 502025013602 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 502025013603 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 502025013604 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 502025013605 putative active site [active] 502025013606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025013607 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 502025013608 NAD(P) binding site [chemical binding]; other site 502025013609 catalytic residues [active] 502025013610 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 502025013611 SelR domain; Region: SelR; pfam01641 502025013612 Protein of unknown function (DUF962); Region: DUF962; cl01879 502025013613 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 502025013614 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025013615 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025013616 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025013617 putative acyl-acceptor binding pocket; other site 502025013618 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025013619 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025013620 putative NAD(P) binding site [chemical binding]; other site 502025013621 active site 502025013622 putative substrate binding site [chemical binding]; other site 502025013623 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 502025013624 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 502025013625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025013626 nucleotide binding region [chemical binding]; other site 502025013627 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 502025013628 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 502025013629 SEC-C motif; Region: SEC-C; pfam02810 502025013630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025013631 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 502025013632 AlkA N-terminal domain; Region: AlkA_N; cl05528 502025013633 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 502025013634 Ubiquitin-like proteins; Region: UBQ; cl00155 502025013635 charged pocket; other site 502025013636 hydrophobic patch; other site 502025013637 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 502025013638 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 502025013639 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 502025013640 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025013641 OsmC-like protein; Region: OsmC; cl00767 502025013642 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 502025013643 putative ADP-ribose binding site [chemical binding]; other site 502025013644 putative active site [active] 502025013645 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 502025013646 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 502025013647 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 502025013648 Cupin domain; Region: Cupin_2; cl09118 502025013649 CheB methylesterase; Region: CheB_methylest; pfam01339 502025013650 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025013651 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025013652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025013653 PAS domain; Region: PAS_10; pfam13596 502025013654 GAF domain; Region: GAF; cl15785 502025013655 GAF domain; Region: GAF_2; pfam13185 502025013656 GAF domain; Region: GAF_2; pfam13185 502025013657 GAF domain; Region: GAF; cl15785 502025013658 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025013659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013660 putative active site [active] 502025013661 heme pocket [chemical binding]; other site 502025013662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013663 dimer interface [polypeptide binding]; other site 502025013664 phosphorylation site [posttranslational modification] 502025013665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013666 ATP binding site [chemical binding]; other site 502025013667 Mg2+ binding site [ion binding]; other site 502025013668 G-X-G motif; other site 502025013669 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013671 active site 502025013672 phosphorylation site [posttranslational modification] 502025013673 intermolecular recognition site; other site 502025013674 dimerization interface [polypeptide binding]; other site 502025013675 CheB methylesterase; Region: CheB_methylest; pfam01339 502025013676 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013677 ligand binding site [chemical binding]; other site 502025013678 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 502025013679 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 502025013680 putative active site [active] 502025013681 catalytic site [active] 502025013682 putative metal binding site [ion binding]; other site 502025013683 Bacterial sugar transferase; Region: Bac_transf; cl00939 502025013684 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 502025013685 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 502025013686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013687 Walker A motif; other site 502025013688 ATP binding site [chemical binding]; other site 502025013689 Walker B motif; other site 502025013690 arginine finger; other site 502025013691 short chain dehydrogenase; Provisional; Region: PRK08278 502025013692 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 502025013693 NAD(P) binding site [chemical binding]; other site 502025013694 homodimer interface [polypeptide binding]; other site 502025013695 active site 502025013696 AMP-binding enzyme; Region: AMP-binding; cl15778 502025013697 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025013698 NAD(P) binding site [chemical binding]; other site 502025013699 catalytic residues [active] 502025013700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025013701 Putative esterase; Region: Esterase; pfam00756 502025013702 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025013703 Family of unknown function (DUF490); Region: DUF490; pfam04357 502025013704 Family of unknown function (DUF490); Region: DUF490; pfam04357 502025013705 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 502025013706 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 502025013707 Surface antigen; Region: Bac_surface_Ag; cl03097 502025013708 D-cysteine desulfhydrase; Validated; Region: PRK03910 502025013709 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025013710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025013711 catalytic residue [active] 502025013712 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 502025013713 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 502025013714 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 502025013715 dimer interface [polypeptide binding]; other site 502025013716 catalytic triad [active] 502025013717 peroxidatic and resolving cysteines [active] 502025013718 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 502025013719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 502025013720 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 502025013721 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 502025013722 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025013723 metal binding site [ion binding]; metal-binding site 502025013724 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 502025013725 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 502025013726 trimer interface [polypeptide binding]; other site 502025013727 active site 502025013728 substrate binding site [chemical binding]; other site 502025013729 CoA binding site [chemical binding]; other site 502025013730 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025013731 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025013732 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025013733 sensory histidine kinase AtoS; Provisional; Region: PRK11360 502025013734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013735 dimer interface [polypeptide binding]; other site 502025013736 phosphorylation site [posttranslational modification] 502025013737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013738 ATP binding site [chemical binding]; other site 502025013739 Mg2+ binding site [ion binding]; other site 502025013740 G-X-G motif; other site 502025013741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013742 active site 502025013743 phosphorylation site [posttranslational modification] 502025013744 intermolecular recognition site; other site 502025013745 dimerization interface [polypeptide binding]; other site 502025013746 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013748 active site 502025013749 phosphorylation site [posttranslational modification] 502025013750 intermolecular recognition site; other site 502025013751 dimerization interface [polypeptide binding]; other site 502025013752 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 502025013753 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 502025013754 putative active site [active] 502025013755 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025013756 phosphopeptide binding site; other site 502025013757 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 502025013758 Helix-turn-helix domains; Region: HTH; cl00088 502025013759 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 502025013760 FAD binding pocket [chemical binding]; other site 502025013761 conserved FAD binding motif [chemical binding]; other site 502025013762 phosphate binding motif [ion binding]; other site 502025013763 beta-alpha-beta structure motif; other site 502025013764 NAD binding pocket [chemical binding]; other site 502025013765 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025013766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025013767 dimerization interface [polypeptide binding]; other site 502025013768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013769 dimer interface [polypeptide binding]; other site 502025013770 phosphorylation site [posttranslational modification] 502025013771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013772 ATP binding site [chemical binding]; other site 502025013773 Mg2+ binding site [ion binding]; other site 502025013774 G-X-G motif; other site 502025013775 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 502025013776 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 502025013777 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025013778 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 502025013779 putative catalytic residue [active] 502025013780 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025013781 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025013782 GTPase RsgA; Reviewed; Region: PRK01889 502025013783 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025013784 RNA binding site [nucleotide binding]; other site 502025013785 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 502025013786 GTPase/Zn-binding domain interface [polypeptide binding]; other site 502025013787 GTP/Mg2+ binding site [chemical binding]; other site 502025013788 G4 box; other site 502025013789 G5 box; other site 502025013790 G1 box; other site 502025013791 Switch I region; other site 502025013792 G2 box; other site 502025013793 G3 box; other site 502025013794 Switch II region; other site 502025013795 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 502025013796 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025013797 dimer interface [polypeptide binding]; other site 502025013798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025013799 catalytic residue [active] 502025013800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 502025013801 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 502025013802 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 502025013803 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 502025013804 substrate binding pocket [chemical binding]; other site 502025013805 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 502025013806 B12 binding site [chemical binding]; other site 502025013807 cobalt ligand [ion binding]; other site 502025013808 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 502025013809 acetolactate synthase; Reviewed; Region: PRK08322 502025013810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025013811 PYR/PP interface [polypeptide binding]; other site 502025013812 dimer interface [polypeptide binding]; other site 502025013813 TPP binding site [chemical binding]; other site 502025013814 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 502025013815 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 502025013816 TPP-binding site [chemical binding]; other site 502025013817 dimer interface [polypeptide binding]; other site 502025013818 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 502025013819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025013820 NAD(P) binding site [chemical binding]; other site 502025013821 catalytic residues [active] 502025013822 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 502025013823 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 502025013824 active site 502025013825 homodimer interface [polypeptide binding]; other site 502025013826 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 502025013827 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025013828 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025013829 structural tetrad; other site 502025013830 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 502025013831 C-terminal peptidase (prc); Region: prc; TIGR00225 502025013832 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 502025013833 protein binding site [polypeptide binding]; other site 502025013834 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 502025013835 Domain interface; other site 502025013836 Peptide binding site; other site 502025013837 Active site tetrad [active] 502025013838 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025013839 active site 502025013840 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025013841 catalytic tetrad [active] 502025013842 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 502025013843 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 502025013844 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 502025013845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013846 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013847 active site 502025013848 ATP binding site [chemical binding]; other site 502025013849 substrate binding site [chemical binding]; other site 502025013850 activation loop (A-loop); other site 502025013851 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 502025013852 TPR repeat; Region: TPR_11; pfam13414 502025013853 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 502025013854 catalytic residues [active] 502025013855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013856 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013857 active site 502025013858 ATP binding site [chemical binding]; other site 502025013859 substrate binding site [chemical binding]; other site 502025013860 activation loop (A-loop); other site 502025013861 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025013862 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025013863 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025013864 putative catalytic site [active] 502025013865 putative metal binding site [ion binding]; other site 502025013866 putative phosphate binding site [ion binding]; other site 502025013867 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 502025013868 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 502025013869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025013870 Walker A/P-loop; other site 502025013871 ATP binding site [chemical binding]; other site 502025013872 Q-loop/lid; other site 502025013873 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025013874 ABC transporter signature motif; other site 502025013875 Walker B; other site 502025013876 D-loop; other site 502025013877 ABC transporter; Region: ABC_tran_2; pfam12848 502025013878 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025013879 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 502025013880 active site 502025013881 putative substrate binding region [chemical binding]; other site 502025013882 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025013883 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025013884 active site 502025013885 catalytic triad [active] 502025013886 calcium binding site 1 [ion binding]; other site 502025013887 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 502025013888 rRNA interaction site [nucleotide binding]; other site 502025013889 S8 interaction site; other site 502025013890 putative laminin-1 binding site; other site 502025013891 elongation factor Ts; Reviewed; Region: tsf; PRK12332 502025013892 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 502025013893 Elongation factor TS; Region: EF_TS; pfam00889 502025013894 ribosome recycling factor; Reviewed; Region: frr; PRK00083 502025013895 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 502025013896 hinge region; other site 502025013897 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013898 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013899 active site 502025013900 ATP binding site [chemical binding]; other site 502025013901 substrate binding site [chemical binding]; other site 502025013902 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013903 substrate binding site [chemical binding]; other site 502025013904 activation loop (A-loop); other site 502025013905 activation loop (A-loop); other site 502025013906 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 502025013907 putative active site [active] 502025013908 dimerization interface [polypeptide binding]; other site 502025013909 putative tRNAtyr binding site [nucleotide binding]; other site 502025013910 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 502025013911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025013912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025013913 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025013914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013916 active site 502025013917 ATP binding site [chemical binding]; other site 502025013918 substrate binding site [chemical binding]; other site 502025013919 activation loop (A-loop); other site 502025013920 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 502025013921 dimer interface [polypeptide binding]; other site 502025013922 substrate binding site [chemical binding]; other site 502025013923 metal binding site [ion binding]; metal-binding site 502025013924 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 502025013925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 502025013926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025013928 active site 502025013929 Surface antigen; Region: Bac_surface_Ag; cl03097 502025013930 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 502025013931 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 502025013932 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025013933 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025013934 catalytic triad [active] 502025013935 putative active site [active] 502025013936 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 502025013937 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 502025013938 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025013939 putative active site pocket [active] 502025013940 dimerization interface [polypeptide binding]; other site 502025013941 putative catalytic residue [active] 502025013942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025013943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025013944 active site 502025013945 catalytic tetrad [active] 502025013946 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013947 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013948 active site 502025013949 ATP binding site [chemical binding]; other site 502025013950 substrate binding site [chemical binding]; other site 502025013951 activation loop (A-loop); other site 502025013952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025013953 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025013954 structural tetrad; other site 502025013955 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025013956 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025013957 structural tetrad; other site 502025013958 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025013959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013960 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 502025013961 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025013962 putative [4Fe-4S] binding site [ion binding]; other site 502025013963 putative molybdopterin cofactor binding site [chemical binding]; other site 502025013964 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 502025013965 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025013966 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025013967 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025013968 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025013969 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025013970 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025013971 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025013972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013973 active site 502025013974 phosphorylation site [posttranslational modification] 502025013975 intermolecular recognition site; other site 502025013976 dimerization interface [polypeptide binding]; other site 502025013977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013978 Walker A motif; other site 502025013979 ATP binding site [chemical binding]; other site 502025013980 Walker B motif; other site 502025013981 arginine finger; other site 502025013982 Helix-turn-helix domains; Region: HTH; cl00088 502025013983 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 502025013984 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 502025013985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013986 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025013987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025013988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025013989 DNA binding residues [nucleotide binding] 502025013990 Putative zinc-finger; Region: zf-HC2; cl15806 502025013991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013992 active site 502025013993 phosphorylation site [posttranslational modification] 502025013994 intermolecular recognition site; other site 502025013995 dimerization interface [polypeptide binding]; other site 502025013996 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 502025013997 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025013998 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 502025013999 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025014000 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025014001 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 502025014002 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 502025014003 HflX GTPase family; Region: HflX; cd01878 502025014004 G1 box; other site 502025014005 GTP/Mg2+ binding site [chemical binding]; other site 502025014006 Switch I region; other site 502025014007 G2 box; other site 502025014008 G3 box; other site 502025014009 Switch II region; other site 502025014010 G4 box; other site 502025014011 G5 box; other site 502025014012 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 502025014013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025014014 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 502025014015 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025014016 Zn binding site [ion binding]; other site 502025014017 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014019 active site 502025014020 ATP binding site [chemical binding]; other site 502025014021 substrate binding site [chemical binding]; other site 502025014022 activation loop (A-loop); other site 502025014023 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014026 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014027 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 502025014028 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 502025014029 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 502025014030 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 502025014031 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025014032 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025014033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014034 dimer interface [polypeptide binding]; other site 502025014035 phosphorylation site [posttranslational modification] 502025014036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014037 ATP binding site [chemical binding]; other site 502025014038 Mg2+ binding site [ion binding]; other site 502025014039 G-X-G motif; other site 502025014040 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 502025014041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025014042 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 502025014043 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014045 active site 502025014046 phosphorylation site [posttranslational modification] 502025014047 intermolecular recognition site; other site 502025014048 dimerization interface [polypeptide binding]; other site 502025014049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025014050 PAS domain; Region: PAS_9; pfam13426 502025014051 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025014052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025014053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014054 dimer interface [polypeptide binding]; other site 502025014055 phosphorylation site [posttranslational modification] 502025014056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014057 ATP binding site [chemical binding]; other site 502025014058 Mg2+ binding site [ion binding]; other site 502025014059 G-X-G motif; other site 502025014060 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025014061 dimer interface [polypeptide binding]; other site 502025014062 [2Fe-2S] cluster binding site [ion binding]; other site 502025014063 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025014064 classical (c) SDRs; Region: SDR_c; cd05233 502025014065 NAD(P) binding site [chemical binding]; other site 502025014066 active site 502025014067 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025014068 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025014069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025014070 catalytic residue [active] 502025014071 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025014072 oligomerisation interface [polypeptide binding]; other site 502025014073 mobile loop; other site 502025014074 roof hairpin; other site 502025014075 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 502025014076 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 502025014077 ring oligomerisation interface [polypeptide binding]; other site 502025014078 ATP/Mg binding site [chemical binding]; other site 502025014079 stacking interactions; other site 502025014080 hinge regions; other site 502025014081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025014082 Surface antigen; Region: Bac_surface_Ag; cl03097 502025014083 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 502025014084 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 502025014085 Ion channel; Region: Ion_trans_2; cl11596 502025014086 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 502025014087 intracellular protease, PfpI family; Region: PfpI; TIGR01382 502025014088 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 502025014089 proposed catalytic triad [active] 502025014090 conserved cys residue [active] 502025014091 heat shock protein 90; Provisional; Region: PRK05218 502025014092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025014093 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025014094 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025014095 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025014096 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025014097 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025014098 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 502025014099 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 502025014100 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 502025014101 Walker A/P-loop; other site 502025014102 ATP binding site [chemical binding]; other site 502025014103 Q-loop/lid; other site 502025014104 ABC transporter signature motif; other site 502025014105 Walker B; other site 502025014106 D-loop; other site 502025014107 H-loop/switch region; other site 502025014108 short chain dehydrogenase; Provisional; Region: PRK07023 502025014109 classical (c) SDRs; Region: SDR_c; cd05233 502025014110 NAD(P) binding site [chemical binding]; other site 502025014111 active site 502025014112 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 502025014113 catalytic residues [active] 502025014114 dimer interface [polypeptide binding]; other site 502025014115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014117 active site 502025014118 ATP binding site [chemical binding]; other site 502025014119 substrate binding site [chemical binding]; other site 502025014120 activation loop (A-loop); other site 502025014121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014123 binding surface 502025014124 TPR motif; other site 502025014125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014127 TPR motif; other site 502025014128 binding surface 502025014129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014132 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 502025014134 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 502025014135 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 502025014136 Moco binding site; other site 502025014137 metal coordination site [ion binding]; other site 502025014138 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 502025014139 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 502025014140 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 502025014141 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 502025014142 putative active site [active] 502025014143 catalytic site [active] 502025014144 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 502025014145 putative active site [active] 502025014146 catalytic site [active] 502025014147 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 502025014148 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 502025014149 dimerization interface [polypeptide binding]; other site 502025014150 ligand binding site [chemical binding]; other site 502025014151 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 502025014152 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 502025014153 Walker A/P-loop; other site 502025014154 ATP binding site [chemical binding]; other site 502025014155 Q-loop/lid; other site 502025014156 ABC transporter signature motif; other site 502025014157 Walker B; other site 502025014158 D-loop; other site 502025014159 H-loop/switch region; other site 502025014160 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 502025014161 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 502025014162 Walker A/P-loop; other site 502025014163 ATP binding site [chemical binding]; other site 502025014164 Q-loop/lid; other site 502025014165 ABC transporter signature motif; other site 502025014166 Walker B; other site 502025014167 D-loop; other site 502025014168 H-loop/switch region; other site 502025014169 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 502025014170 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 502025014171 TM-ABC transporter signature motif; other site 502025014172 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 502025014173 TM-ABC transporter signature motif; other site 502025014174 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025014175 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025014176 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 502025014177 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 502025014178 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 502025014179 dimer interface [polypeptide binding]; other site 502025014180 catalytic triad [active] 502025014181 alpha-glucosidase; Provisional; Region: PRK10137 502025014182 LabA_like proteins; Region: LabA_like; cd06167 502025014183 putative metal binding site [ion binding]; other site 502025014184 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025014185 active site 502025014186 metal binding site [ion binding]; metal-binding site 502025014187 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014188 phosphopeptide binding site; other site 502025014189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025014190 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025014191 Walker A motif; other site 502025014192 ATP binding site [chemical binding]; other site 502025014193 Walker B motif; other site 502025014194 arginine finger; other site 502025014195 Helix-turn-helix domains; Region: HTH; cl00088 502025014196 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 502025014197 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025014198 Zn binding site [ion binding]; other site 502025014199 HEAT repeats; Region: HEAT_2; pfam13646 502025014200 HEAT repeats; Region: HEAT_2; pfam13646 502025014201 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 502025014202 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 502025014203 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025014204 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025014205 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 502025014206 dimerization interface [polypeptide binding]; other site 502025014207 active site 502025014208 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 502025014209 folate binding site [chemical binding]; other site 502025014210 NADP+ binding site [chemical binding]; other site 502025014211 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025014212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014213 NAD(P) binding pocket [chemical binding]; other site 502025014214 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 502025014215 aromatic arch; other site 502025014216 DCoH dimer interaction site [polypeptide binding]; other site 502025014217 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 502025014218 DCoH tetramer interaction site [polypeptide binding]; other site 502025014219 substrate binding site [chemical binding]; other site 502025014220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014222 active site 502025014223 ATP binding site [chemical binding]; other site 502025014224 substrate binding site [chemical binding]; other site 502025014225 activation loop (A-loop); other site 502025014226 Protein phosphatase 2C; Region: PP2C; pfam00481 502025014227 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025014228 active site 502025014229 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025014230 ligand binding site [chemical binding]; other site 502025014231 flexible hinge region; other site 502025014232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025014233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014234 NAD(P) binding site [chemical binding]; other site 502025014235 active site 502025014236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014237 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 502025014238 NAD(P) binding site [chemical binding]; other site 502025014239 active site 502025014240 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 502025014241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025014242 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025014243 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025014244 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025014245 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025014246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025014247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 502025014248 active site 502025014249 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 502025014250 CAAX protease self-immunity; Region: Abi; cl00558 502025014251 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 502025014252 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 502025014253 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 502025014254 catalytic core [active] 502025014255 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025014256 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025014257 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025014258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014259 binding surface 502025014260 TPR motif; other site 502025014261 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025014262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014263 TPR motif; other site 502025014264 binding surface 502025014265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014266 TPR motif; other site 502025014267 binding surface 502025014268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014269 TPR motif; other site 502025014270 binding surface 502025014271 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025014272 anti sigma factor interaction site; other site 502025014273 regulatory phosphorylation site [posttranslational modification]; other site 502025014274 PAS domain; Region: PAS_9; pfam13426 502025014275 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025014276 anti sigma factor interaction site; other site 502025014277 regulatory phosphorylation site [posttranslational modification]; other site 502025014278 PAS fold; Region: PAS_4; pfam08448 502025014279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014280 dimer interface [polypeptide binding]; other site 502025014281 phosphorylation site [posttranslational modification] 502025014282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014283 ATP binding site [chemical binding]; other site 502025014284 Mg2+ binding site [ion binding]; other site 502025014285 G-X-G motif; other site 502025014286 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014288 active site 502025014289 phosphorylation site [posttranslational modification] 502025014290 intermolecular recognition site; other site 502025014291 dimerization interface [polypeptide binding]; other site 502025014292 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025014293 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 502025014294 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025014295 AMP-binding enzyme; Region: AMP-binding; cl15778 502025014296 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014298 AAA domain; Region: AAA_21; pfam13304 502025014299 Walker A/P-loop; other site 502025014300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014301 Walker B; other site 502025014302 D-loop; other site 502025014303 H-loop/switch region; other site 502025014304 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535 502025014305 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 502025014306 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025014307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025014308 carboxyltransferase (CT) interaction site; other site 502025014309 biotinylation site [posttranslational modification]; other site 502025014310 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 502025014311 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 502025014312 Arginase family; Region: Arginase; cl00306 502025014313 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 502025014314 putative di-iron ligands [ion binding]; other site 502025014315 AAA domain; Region: AAA_22; pfam13401 502025014316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014317 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025014318 NMT1-like family; Region: NMT1_2; cl15260 502025014319 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 502025014320 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 502025014321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014322 dimer interface [polypeptide binding]; other site 502025014323 conserved gate region; other site 502025014324 putative PBP binding loops; other site 502025014325 ABC-ATPase subunit interface; other site 502025014326 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 502025014327 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 502025014328 Walker A/P-loop; other site 502025014329 ATP binding site [chemical binding]; other site 502025014330 Q-loop/lid; other site 502025014331 ABC transporter signature motif; other site 502025014332 Walker B; other site 502025014333 D-loop; other site 502025014334 H-loop/switch region; other site 502025014335 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025014336 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 502025014337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025014338 DNA binding residues [nucleotide binding] 502025014339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025014341 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 502025014342 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 502025014343 hinge; other site 502025014344 active site 502025014345 ATP phosphoribosyltransferase; Region: HisG; cl15266 502025014346 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025014347 ligand binding site [chemical binding]; other site 502025014348 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014349 phosphopeptide binding site; other site 502025014350 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014351 phosphopeptide binding site; other site 502025014352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014353 TPR motif; other site 502025014354 FtsX-like permease family; Region: FtsX; cl15850 502025014355 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 502025014356 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025014357 Walker A/P-loop; other site 502025014358 ATP binding site [chemical binding]; other site 502025014359 Q-loop/lid; other site 502025014360 ABC transporter signature motif; other site 502025014361 Walker B; other site 502025014362 D-loop; other site 502025014363 H-loop/switch region; other site 502025014364 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025014365 metal binding site [ion binding]; metal-binding site 502025014366 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025014367 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 502025014368 Peptidase S46; Region: Peptidase_S46; pfam10459 502025014369 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025014370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025014371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025014372 active site 502025014373 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025014374 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 502025014375 active site 502025014376 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025014377 Cytochrome P450; Region: p450; pfam00067 502025014378 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025014379 active site 502025014380 catalytic residues [active] 502025014381 enoyl-CoA hydratase; Provisional; Region: PRK06563 502025014382 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025014383 substrate binding site [chemical binding]; other site 502025014384 oxyanion hole (OAH) forming residues; other site 502025014385 trimer interface [polypeptide binding]; other site 502025014386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025014387 PhoD-like phosphatase; Region: PhoD; pfam09423 502025014388 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025014389 putative active site [active] 502025014390 putative metal binding site [ion binding]; other site 502025014391 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025014392 Cupin domain; Region: Cupin_2; cl09118 502025014393 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025014394 active site 502025014395 Zn binding site [ion binding]; other site 502025014396 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 502025014397 active site 502025014398 catalytic triad [active] 502025014399 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025014400 ribonuclease G; Provisional; Region: PRK11712 502025014401 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 502025014402 homodimer interface [polypeptide binding]; other site 502025014403 oligonucleotide binding site [chemical binding]; other site 502025014404 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014405 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014406 active site 502025014407 ATP binding site [chemical binding]; other site 502025014408 substrate binding site [chemical binding]; other site 502025014409 activation loop (A-loop); other site 502025014410 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 502025014411 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 502025014412 active site 502025014413 8-oxo-dGMP binding site [chemical binding]; other site 502025014414 nudix motif; other site 502025014415 metal binding site [ion binding]; metal-binding site 502025014416 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025014417 active site residue [active] 502025014418 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025014419 AMP-binding enzyme; Region: AMP-binding; cl15778 502025014420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 502025014421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014422 dimer interface [polypeptide binding]; other site 502025014423 conserved gate region; other site 502025014424 putative PBP binding loops; other site 502025014425 ABC-ATPase subunit interface; other site 502025014426 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 502025014427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014428 dimer interface [polypeptide binding]; other site 502025014429 conserved gate region; other site 502025014430 putative PBP binding loops; other site 502025014431 ABC-ATPase subunit interface; other site 502025014432 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025014433 iron-sulfur cluster [ion binding]; other site 502025014434 [2Fe-2S] cluster binding site [ion binding]; other site 502025014435 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025014436 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025014437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014438 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 502025014439 argininosuccinate lyase; Provisional; Region: PRK00855 502025014440 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 502025014441 active sites [active] 502025014442 tetramer interface [polypeptide binding]; other site 502025014443 diaminopimelate decarboxylase; Region: lysA; TIGR01048 502025014444 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 502025014445 active site 502025014446 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025014447 substrate binding site [chemical binding]; other site 502025014448 catalytic residues [active] 502025014449 dimer interface [polypeptide binding]; other site 502025014450 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014451 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014452 active site 502025014453 ATP binding site [chemical binding]; other site 502025014454 substrate binding site [chemical binding]; other site 502025014455 activation loop (A-loop); other site 502025014456 AAA domain; Region: AAA_22; pfam13401 502025014457 Predicted ATPase [General function prediction only]; Region: COG3899 502025014458 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014459 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014460 active site 502025014461 ATP binding site [chemical binding]; other site 502025014462 substrate binding site [chemical binding]; other site 502025014463 activation loop (A-loop); other site 502025014464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014466 active site 502025014467 ATP binding site [chemical binding]; other site 502025014468 substrate binding site [chemical binding]; other site 502025014469 activation loop (A-loop); other site 502025014470 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014472 substrate binding site [chemical binding]; other site 502025014473 activation loop (A-loop); other site 502025014474 Predicted ATPase [General function prediction only]; Region: COG3899 502025014475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014476 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 502025014477 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 502025014478 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 502025014479 active site 502025014480 dimer interface [polypeptide binding]; other site 502025014481 effector binding site; other site 502025014482 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 502025014483 TSCPD domain; Region: TSCPD; cl14834 502025014484 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014486 active site 502025014487 phosphorylation site [posttranslational modification] 502025014488 intermolecular recognition site; other site 502025014489 dimerization interface [polypeptide binding]; other site 502025014490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014491 dimer interface [polypeptide binding]; other site 502025014492 phosphorylation site [posttranslational modification] 502025014493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014494 ATP binding site [chemical binding]; other site 502025014495 Mg2+ binding site [ion binding]; other site 502025014496 G-X-G motif; other site 502025014497 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 502025014498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014499 ATP binding site [chemical binding]; other site 502025014500 Mg2+ binding site [ion binding]; other site 502025014501 G-X-G motif; other site 502025014502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025014503 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 502025014504 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 502025014505 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025014506 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025014507 active site 502025014508 metal binding site [ion binding]; metal-binding site 502025014509 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025014510 phosphopeptide binding site; other site 502025014511 aspartate aminotransferase; Provisional; Region: PRK06836 502025014512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025014513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025014514 homodimer interface [polypeptide binding]; other site 502025014515 catalytic residue [active] 502025014516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025014517 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 502025014518 Helix-turn-helix domains; Region: HTH; cl00088 502025014519 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 502025014520 Flavoprotein; Region: Flavoprotein; cl08021 502025014521 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 502025014522 Flavoprotein; Region: Flavoprotein; cl08021 502025014523 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025014524 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025014525 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025014526 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025014527 acetyl-CoA synthetase; Provisional; Region: PRK00174 502025014528 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 502025014529 AMP-binding enzyme; Region: AMP-binding; cl15778 502025014530 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014531 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025014532 homotrimer interaction site [polypeptide binding]; other site 502025014533 putative active site [active] 502025014534 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 502025014535 ADP-ribose binding site [chemical binding]; other site 502025014536 Peptidase family M48; Region: Peptidase_M48; cl12018 502025014537 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 502025014538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014539 active site 502025014540 phosphorylation site [posttranslational modification] 502025014541 intermolecular recognition site; other site 502025014542 dimerization interface [polypeptide binding]; other site 502025014543 Helix-turn-helix domains; Region: HTH; cl00088 502025014544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025014545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014546 ATP binding site [chemical binding]; other site 502025014547 Mg2+ binding site [ion binding]; other site 502025014548 G-X-G motif; other site 502025014549 Ion channel; Region: Ion_trans_2; cl11596 502025014550 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 502025014551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014552 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025014553 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025014554 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 502025014555 primosome assembly protein PriA; Validated; Region: PRK05580 502025014556 primosome assembly protein PriA; Validated; Region: PRK05580 502025014557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025014558 ATP binding site [chemical binding]; other site 502025014559 putative Mg++ binding site [ion binding]; other site 502025014560 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 502025014561 active site 502025014562 tetramer interface; other site 502025014563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025014564 DNA binding residues [nucleotide binding] 502025014565 dimerization interface [polypeptide binding]; other site 502025014566 peptide chain release factor 2; Validated; Region: prfB; PRK00578 502025014567 RF-1 domain; Region: RF-1; cl02875 502025014568 RF-1 domain; Region: RF-1; cl02875 502025014569 amidophosphoribosyltransferase; Provisional; Region: PRK09123 502025014570 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 502025014571 active site 502025014572 tetramer interface [polypeptide binding]; other site 502025014573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025014574 active site 502025014575 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014576 phosphopeptide binding site; other site 502025014577 SPX domain; Region: SPX; cl02238 502025014578 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025014579 DNA binding site [nucleotide binding] 502025014580 active site 502025014581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014582 dimer interface [polypeptide binding]; other site 502025014583 phosphorylation site [posttranslational modification] 502025014584 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 502025014585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014586 ATP binding site [chemical binding]; other site 502025014587 Mg2+ binding site [ion binding]; other site 502025014588 G-X-G motif; other site 502025014589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025014590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025014591 dimerization interface [polypeptide binding]; other site 502025014592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014593 dimer interface [polypeptide binding]; other site 502025014594 phosphorylation site [posttranslational modification] 502025014595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014596 ATP binding site [chemical binding]; other site 502025014597 Mg2+ binding site [ion binding]; other site 502025014598 G-X-G motif; other site 502025014599 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014601 active site 502025014602 phosphorylation site [posttranslational modification] 502025014603 intermolecular recognition site; other site 502025014604 dimerization interface [polypeptide binding]; other site 502025014605 Sulfatase; Region: Sulfatase; cl10460 502025014606 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 502025014607 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 502025014608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025014609 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 502025014610 fumarate hydratase; Provisional; Region: PRK15389 502025014611 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 502025014612 Fumarase C-terminus; Region: Fumerase_C; cl00795 502025014613 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 502025014614 integrin inhibitor binding pocket; other site 502025014615 metal ion-dependent adhesion site (MIDAS); other site 502025014616 integrin-collagen binding site; other site 502025014617 putative vWF-collagen binding site; other site 502025014618 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 502025014619 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 502025014620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025014621 putative active site [active] 502025014622 heme pocket [chemical binding]; other site 502025014623 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025014624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025014625 putative active site [active] 502025014626 heme pocket [chemical binding]; other site 502025014627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025014628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014629 ATP binding site [chemical binding]; other site 502025014630 Mg2+ binding site [ion binding]; other site 502025014631 G-X-G motif; other site 502025014632 6-phosphogluconolactonase; Provisional; Region: PRK11028 502025014633 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025014634 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025014635 MAPEG family; Region: MAPEG; cl09190 502025014636 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025014637 BNR repeat-like domain; Region: BNR_2; pfam13088 502025014638 CHAT domain; Region: CHAT; pfam12770 502025014639 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025014640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025014641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025014642 DNA binding residues [nucleotide binding] 502025014643 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014644 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014645 active site 502025014646 ATP binding site [chemical binding]; other site 502025014647 substrate binding site [chemical binding]; other site 502025014648 activation loop (A-loop); other site 502025014649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025014651 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 502025014652 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 502025014653 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 502025014654 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025014655 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025014656 CRISPR-associated protein; Region: TIGR03986 502025014657 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025014658 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 502025014659 TIR domain; Region: TIR_2; cl15770 502025014660 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025014661 Predicted GTPase [General function prediction only]; Region: COG0218 502025014662 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 502025014663 G1 box; other site 502025014664 GTP/Mg2+ binding site [chemical binding]; other site 502025014665 Switch I region; other site 502025014666 G2 box; other site 502025014667 G3 box; other site 502025014668 Switch II region; other site 502025014669 G4 box; other site 502025014670 G5 box; other site 502025014671 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 502025014672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025014673 Coenzyme A binding pocket [chemical binding]; other site 502025014674 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025014675 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014676 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014677 active site 502025014678 ATP binding site [chemical binding]; other site 502025014679 substrate binding site [chemical binding]; other site 502025014680 activation loop (A-loop); other site 502025014681 Rhomboid family; Region: Rhomboid; cl11446 502025014682 tetratricopeptide repeat protein; Provisional; Region: PRK11788 502025014683 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 502025014684 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 502025014685 Protein kinase domain; Region: Pkinase; pfam00069 502025014686 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014687 active site 502025014688 ATP binding site [chemical binding]; other site 502025014689 substrate binding site [chemical binding]; other site 502025014690 activation loop (A-loop); other site 502025014691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014693 TPR motif; other site 502025014694 binding surface 502025014695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014696 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014697 Protein of unknown function, DUF393; Region: DUF393; cl01136 502025014698 YndJ-like protein; Region: YndJ; pfam14158 502025014699 Archaeal ADP-dependent phosphofructokinase/glucokinase [Carbohydrate transport and metabolism]; Region: COG4809 502025014700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025014701 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014702 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014703 active site 502025014704 ATP binding site [chemical binding]; other site 502025014705 substrate binding site [chemical binding]; other site 502025014706 activation loop (A-loop); other site 502025014707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014708 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014709 structural tetrad; other site 502025014710 PQQ-like domain; Region: PQQ_2; pfam13360 502025014711 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014712 structural tetrad; other site 502025014713 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025014714 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014715 structural tetrad; other site 502025014716 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014718 active site 502025014719 ATP binding site [chemical binding]; other site 502025014720 substrate binding site [chemical binding]; other site 502025014721 activation loop (A-loop); other site 502025014722 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 502025014723 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 502025014724 Cupin domain; Region: Cupin_2; cl09118 502025014725 thymidylate kinase; Validated; Region: tmk; PRK00698 502025014726 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 502025014727 TMP-binding site; other site 502025014728 ATP-binding site [chemical binding]; other site 502025014729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014730 active site 502025014731 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025014732 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025014733 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 502025014734 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025014735 catalytic residues [active] 502025014736 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025014737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014738 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 502025014739 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025014740 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 502025014741 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025014742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025014743 Surface antigen; Region: Bac_surface_Ag; cl03097 502025014744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025014745 binding surface 502025014746 TPR motif; other site 502025014747 TPR repeat; Region: TPR_11; pfam13414 502025014748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014749 binding surface 502025014750 TPR motif; other site 502025014751 TPR repeat; Region: TPR_11; pfam13414 502025014752 TPR repeat; Region: TPR_11; pfam13414 502025014753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025014754 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014755 phosphopeptide binding site; other site 502025014756 quasi-rSAM protein, GG-Bacteroidales system; Region: quasi_rSAM; TIGR04150 502025014757 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 502025014758 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 502025014759 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 502025014760 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025014761 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 502025014762 putative di-iron ligands [ion binding]; other site 502025014763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014764 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014765 active site 502025014766 ATP binding site [chemical binding]; other site 502025014767 substrate binding site [chemical binding]; other site 502025014768 activation loop (A-loop); other site 502025014769 Predicted ATPase [General function prediction only]; Region: COG3899 502025014770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014771 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014772 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025014773 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025014774 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025014775 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025014776 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025014777 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025014778 catalytic loop [active] 502025014779 iron binding site [ion binding]; other site 502025014780 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025014781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025014782 putative active site [active] 502025014783 heme pocket [chemical binding]; other site 502025014784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014785 dimer interface [polypeptide binding]; other site 502025014786 phosphorylation site [posttranslational modification] 502025014787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014788 ATP binding site [chemical binding]; other site 502025014789 Mg2+ binding site [ion binding]; other site 502025014790 G-X-G motif; other site 502025014791 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 502025014792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025014793 RNA binding surface [nucleotide binding]; other site 502025014794 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 502025014795 active site 502025014796 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 502025014797 ScpA/B protein; Region: ScpA_ScpB; cl00598 502025014798 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 502025014799 active site 502025014800 putative substrate binding region [chemical binding]; other site 502025014801 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 502025014802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025014803 active site 502025014804 DNA binding site [nucleotide binding] 502025014805 Int/Topo IB signature motif; other site 502025014806 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025014807 ligand binding site [chemical binding]; other site 502025014808 flexible hinge region; other site 502025014809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025014810 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025014811 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 502025014812 Walker A/P-loop; other site 502025014813 ATP binding site [chemical binding]; other site 502025014814 Q-loop/lid; other site 502025014815 ABC transporter signature motif; other site 502025014816 Walker B; other site 502025014817 D-loop; other site 502025014818 H-loop/switch region; other site 502025014819 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 502025014820 ATP cone domain; Region: ATP-cone; pfam03477 502025014821 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 502025014822 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 502025014823 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 502025014824 dimer interface [polypeptide binding]; other site 502025014825 active site 502025014826 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025014827 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025014828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014829 NAD(P) binding site [chemical binding]; other site 502025014830 active site 502025014831 Acyl transferase domain; Region: Acyl_transf_1; cl08282 502025014832 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025014833 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 502025014834 putative catalytic site [active] 502025014835 putative phosphate binding site [ion binding]; other site 502025014836 active site 502025014837 metal binding site A [ion binding]; metal-binding site 502025014838 DNA binding site [nucleotide binding] 502025014839 putative AP binding site [nucleotide binding]; other site 502025014840 putative metal binding site B [ion binding]; other site 502025014841 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025014842 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025014843 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025014844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014845 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 502025014846 Walker A/P-loop; other site 502025014847 ATP binding site [chemical binding]; other site 502025014848 Q-loop/lid; other site 502025014849 ABC transporter signature motif; other site 502025014850 Walker B; other site 502025014851 D-loop; other site 502025014852 H-loop/switch region; other site 502025014853 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025014854 GAF domain; Region: GAF; cl15785 502025014855 GAF domain; Region: GAF; cl15785 502025014856 GAF domain; Region: GAF_2; pfam13185 502025014857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 502025014859 dimer interface [polypeptide binding]; other site 502025014860 phosphorylation site [posttranslational modification] 502025014861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014862 ATP binding site [chemical binding]; other site 502025014863 Mg2+ binding site [ion binding]; other site 502025014864 G-X-G motif; other site 502025014865 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 502025014866 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 502025014867 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025014868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025014869 CHAT domain; Region: CHAT; pfam12770 502025014870 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 502025014871 active site 502025014872 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025014873 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 502025014874 Transglycosylase; Region: Transgly; cl07896 502025014875 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 502025014876 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025014877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025014878 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 502025014879 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014880 phosphopeptide binding site; other site 502025014881 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025014882 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 502025014883 Zn binding site [ion binding]; other site 502025014884 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 502025014885 LysE type translocator; Region: LysE; cl00565 502025014886 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025014887 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025014888 putative active site [active] 502025014889 putative metal binding site [ion binding]; other site 502025014890 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025014891 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 502025014892 putative ligand binding pocket/active site [active] 502025014893 putative metal binding site [ion binding]; other site 502025014894 ferrochelatase; Reviewed; Region: hemH; PRK00035 502025014895 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 502025014896 C-terminal domain interface [polypeptide binding]; other site 502025014897 active site 502025014898 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 502025014899 active site 502025014900 N-terminal domain interface [polypeptide binding]; other site 502025014901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025014902 active site 502025014903 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025014904 glycosyltransferase, MGT family; Region: MGT; TIGR01426 502025014905 active site 502025014906 TDP-binding site; other site 502025014907 acceptor substrate-binding pocket; other site 502025014908 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 502025014909 active site 502025014910 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 502025014911 dimer interface [polypeptide binding]; other site 502025014912 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025014913 Ligand Binding Site [chemical binding]; other site 502025014914 Molecular Tunnel; other site 502025014915 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025014916 Ligand Binding Site [chemical binding]; other site 502025014917 Molecular Tunnel; other site 502025014918 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 502025014919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025014920 FeS/SAM binding site; other site 502025014921 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 502025014922 Protein of unknown function, DUF393; Region: DUF393; cl01136 502025014923 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 502025014924 active site 502025014925 catalytic site [active] 502025014926 substrate binding site [chemical binding]; other site 502025014927 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 502025014928 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025014929 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 502025014930 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 502025014931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014932 ATP binding site [chemical binding]; other site 502025014933 putative Mg++ binding site [ion binding]; other site 502025014934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025014935 nucleotide binding region [chemical binding]; other site 502025014936 ATP-binding site [chemical binding]; other site 502025014937 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 502025014938 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025014939 PA14 domain; Region: PA14; cl08459 502025014940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025014941 non-specific DNA binding site [nucleotide binding]; other site 502025014942 salt bridge; other site 502025014943 sequence-specific DNA binding site [nucleotide binding]; other site 502025014944 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 502025014945 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 502025014946 metal binding triad; other site 502025014947 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025014948 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 502025014949 metal binding triad; other site 502025014950 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025014951 chaperone protein DnaJ; Provisional; Region: PRK10767 502025014952 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025014953 HSP70 interaction site [polypeptide binding]; other site 502025014954 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 502025014955 Zn binding sites [ion binding]; other site 502025014956 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025014957 dimer interface [polypeptide binding]; other site 502025014958 Domain of unknown function (DUF202); Region: DUF202; cl09954 502025014959 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 502025014960 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 502025014961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014962 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 502025014963 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 502025014964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025014965 Walker A/P-loop; other site 502025014966 ATP binding site [chemical binding]; other site 502025014967 Q-loop/lid; other site 502025014968 ABC transporter signature motif; other site 502025014969 Walker B; other site 502025014970 D-loop; other site 502025014971 H-loop/switch region; other site 502025014972 Smr domain; Region: Smr; cl02619 502025014973 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014974 phosphopeptide binding site; other site 502025014975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025014976 metal binding site [ion binding]; metal-binding site 502025014977 active site 502025014978 I-site; other site 502025014979 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 502025014980 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 502025014981 substrate binding pocket [chemical binding]; other site 502025014982 chain length determination region; other site 502025014983 substrate-Mg2+ binding site; other site 502025014984 catalytic residues [active] 502025014985 aspartate-rich region 1; other site 502025014986 active site lid residues [active] 502025014987 aspartate-rich region 2; other site 502025014988 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 502025014989 helix swapped region; other site 502025014990 homodimer interface [polypeptide binding]; other site 502025014991 substrate binding pocket [chemical binding]; other site 502025014992 catalytic residues [active] 502025014993 NADH/NADPH cofactor binding site [chemical binding]; other site 502025014994 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025014995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025014996 S-adenosylmethionine binding site [chemical binding]; other site 502025014997 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025014998 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 502025014999 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 502025015000 dimer interface [polypeptide binding]; other site 502025015001 tetramer interface [polypeptide binding]; other site 502025015002 PYR/PP interface [polypeptide binding]; other site 502025015003 TPP binding site [chemical binding]; other site 502025015004 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 502025015005 TPP-binding site [chemical binding]; other site 502025015006 UbiA prenyltransferase family; Region: UbiA; cl00337 502025015007 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 502025015008 metal binding site [ion binding]; metal-binding site 502025015009 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 502025015010 AMP-binding enzyme; Region: AMP-binding; cl15778 502025015011 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025015012 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025015013 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015014 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025015015 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015016 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025015017 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015018 EamA-like transporter family; Region: EamA; cl01037 502025015019 EamA-like transporter family; Region: EamA; cl01037 502025015020 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 502025015021 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 502025015022 GatB domain; Region: GatB_Yqey; cl11497 502025015023 Y-family of DNA polymerases; Region: PolY; cl12025 502025015024 active site 502025015025 glutathione reductase; Validated; Region: PRK06116 502025015026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025015027 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025015028 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025015029 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025015030 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025015031 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025015032 CoenzymeA binding site [chemical binding]; other site 502025015033 subunit interaction site [polypeptide binding]; other site 502025015034 PHB binding site; other site 502025015035 Peptidase S46; Region: Peptidase_S46; pfam10459 502025015036 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025015037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025015038 putative catalytic site [active] 502025015039 putative metal binding site [ion binding]; other site 502025015040 putative phosphate binding site [ion binding]; other site 502025015041 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025015042 amidase catalytic site [active] 502025015043 Zn binding residues [ion binding]; other site 502025015044 substrate binding site [chemical binding]; other site 502025015045 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 502025015046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015047 S-adenosylmethionine binding site [chemical binding]; other site 502025015048 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 502025015049 putative active site [active] 502025015050 putative metal binding site [ion binding]; other site 502025015051 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025015052 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 502025015053 NAD(P) binding site [chemical binding]; other site 502025015054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025015055 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 502025015056 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 502025015057 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 502025015058 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025015059 Na binding site [ion binding]; other site 502025015060 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025015061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015062 putative active site [active] 502025015063 heme pocket [chemical binding]; other site 502025015064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015065 dimer interface [polypeptide binding]; other site 502025015066 phosphorylation site [posttranslational modification] 502025015067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015068 ATP binding site [chemical binding]; other site 502025015069 Mg2+ binding site [ion binding]; other site 502025015070 G-X-G motif; other site 502025015071 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015073 active site 502025015074 phosphorylation site [posttranslational modification] 502025015075 intermolecular recognition site; other site 502025015076 dimerization interface [polypeptide binding]; other site 502025015077 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025015078 nudix motif; other site 502025015079 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025015080 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 502025015081 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 502025015082 active site 502025015083 transcriptional regulator PhoB; Provisional; Region: PRK10161 502025015084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025015085 metal binding site [ion binding]; metal-binding site 502025015086 active site 502025015087 I-site; other site 502025015088 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 502025015089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015090 Family description; Region: UvrD_C_2; cl15862 502025015091 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025015092 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 502025015093 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025015094 putative active site [active] 502025015095 putative metal binding site [ion binding]; other site 502025015096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015097 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 502025015098 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025015099 Family description; Region: VCBS; pfam13517 502025015100 Family description; Region: VCBS; pfam13517 502025015101 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025015102 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025015103 RHS Repeat; Region: RHS_repeat; cl11982 502025015104 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025015105 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025015106 WYL domain; Region: WYL; cl14852 502025015107 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025015108 WYL domain; Region: WYL; cl14852 502025015109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025015111 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 502025015112 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 502025015113 urocanate hydratase; Provisional; Region: PRK05414 502025015114 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025015115 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025015116 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 502025015117 dimer interface [polypeptide binding]; other site 502025015118 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 502025015119 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025015120 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 502025015121 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 502025015122 active site 502025015123 homotetramer interface [polypeptide binding]; other site 502025015124 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 502025015125 N-formylglutamate amidohydrolase; Region: FGase; cl01522 502025015126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025015127 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 502025015128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025015129 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025015130 active site 502025015131 catalytic tetrad [active] 502025015132 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 502025015133 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025015134 GAF domain; Region: GAF; cl15785 502025015135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015136 dimer interface [polypeptide binding]; other site 502025015137 phosphorylation site [posttranslational modification] 502025015138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015139 ATP binding site [chemical binding]; other site 502025015140 Mg2+ binding site [ion binding]; other site 502025015141 G-X-G motif; other site 502025015142 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025015143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025015144 ligand binding site [chemical binding]; other site 502025015145 Right handed beta helix region; Region: Beta_helix; pfam13229 502025015146 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025015147 N-formylglutamate amidohydrolase; Region: FGase; cl01522 502025015148 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025015149 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 502025015150 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 502025015151 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025015152 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 502025015153 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 502025015154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015155 ATP binding site [chemical binding]; other site 502025015156 Mg2+ binding site [ion binding]; other site 502025015157 G-X-G motif; other site 502025015158 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025015159 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 502025015160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025015161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015162 phosphopeptide binding site; other site 502025015163 Helix-turn-helix domains; Region: HTH; cl00088 502025015164 DNA binding site [nucleotide binding] 502025015165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015167 active site 502025015168 ATP binding site [chemical binding]; other site 502025015169 substrate binding site [chemical binding]; other site 502025015170 activation loop (A-loop); other site 502025015171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015173 active site 502025015174 ATP binding site [chemical binding]; other site 502025015175 substrate binding site [chemical binding]; other site 502025015176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015177 activation loop (A-loop); other site 502025015178 activation loop (A-loop); other site 502025015179 Predicted ATPase [General function prediction only]; Region: COG3899 502025015180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015181 Walker A/P-loop; other site 502025015182 ATP binding site [chemical binding]; other site 502025015183 ABC transporter signature motif; other site 502025015184 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015185 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015187 active site 502025015188 phosphorylation site [posttranslational modification] 502025015189 intermolecular recognition site; other site 502025015190 dimerization interface [polypeptide binding]; other site 502025015191 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015192 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015193 active site 502025015194 ATP binding site [chemical binding]; other site 502025015195 substrate binding site [chemical binding]; other site 502025015196 activation loop (A-loop); other site 502025015197 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 502025015198 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 502025015199 ligand binding site; other site 502025015200 oligomer interface; other site 502025015201 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 502025015202 dimer interface [polypeptide binding]; other site 502025015203 N-terminal domain interface [polypeptide binding]; other site 502025015204 sulfate 1 binding site; other site 502025015205 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 502025015206 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025015207 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025015208 putative C-terminal domain interface [polypeptide binding]; other site 502025015209 putative GSH binding site (G-site) [chemical binding]; other site 502025015210 putative dimer interface [polypeptide binding]; other site 502025015211 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025015212 N-terminal domain interface [polypeptide binding]; other site 502025015213 dimer interface [polypeptide binding]; other site 502025015214 substrate binding pocket (H-site) [chemical binding]; other site 502025015215 Cupin domain; Region: Cupin_2; cl09118 502025015216 Helix-turn-helix domains; Region: HTH; cl00088 502025015217 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025015218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015219 S-adenosylmethionine binding site [chemical binding]; other site 502025015220 putative diguanylate cyclase; Provisional; Region: PRK09776 502025015221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015222 putative active site [active] 502025015223 heme pocket [chemical binding]; other site 502025015224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015225 PAS domain; Region: PAS_9; pfam13426 502025015226 putative active site [active] 502025015227 heme pocket [chemical binding]; other site 502025015228 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025015229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015230 putative active site [active] 502025015231 heme pocket [chemical binding]; other site 502025015232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015233 dimer interface [polypeptide binding]; other site 502025015234 phosphorylation site [posttranslational modification] 502025015235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015236 ATP binding site [chemical binding]; other site 502025015237 Mg2+ binding site [ion binding]; other site 502025015238 G-X-G motif; other site 502025015239 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015241 active site 502025015242 phosphorylation site [posttranslational modification] 502025015243 intermolecular recognition site; other site 502025015244 dimerization interface [polypeptide binding]; other site 502025015245 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015246 Phosphotransferase enzyme family; Region: APH; pfam01636 502025015247 active site 502025015248 substrate binding site [chemical binding]; other site 502025015249 ATP binding site [chemical binding]; other site 502025015250 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025015251 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 502025015252 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025015253 proline dipeptidase; Provisional; Region: PRK13607 502025015254 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 502025015255 active site 502025015256 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015258 active site 502025015259 ATP binding site [chemical binding]; other site 502025015260 substrate binding site [chemical binding]; other site 502025015261 activation loop (A-loop); other site 502025015262 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 502025015263 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 502025015264 putative hexamer interface [polypeptide binding]; other site 502025015265 putative hexagonal pore; other site 502025015266 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 502025015267 putative hexamer interface [polypeptide binding]; other site 502025015268 putative hexagonal pore; other site 502025015269 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 502025015270 putative catalytic cysteine [active] 502025015271 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025015272 Hexamer/Pentamer interface [polypeptide binding]; other site 502025015273 central pore; other site 502025015274 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 502025015275 Hexamer interface [polypeptide binding]; other site 502025015276 Hexagonal pore residue; other site 502025015277 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 502025015278 putative hexamer interface [polypeptide binding]; other site 502025015279 putative hexagonal pore; other site 502025015280 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 502025015281 Hexamer interface [polypeptide binding]; other site 502025015282 Hexagonal pore residue; other site 502025015283 Clostripain family; Region: Peptidase_C11; cl04055 502025015284 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 502025015285 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 502025015286 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 502025015287 TPR repeat; Region: TPR_11; pfam13414 502025015288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015289 binding surface 502025015290 TPR motif; other site 502025015291 TPR repeat; Region: TPR_11; pfam13414 502025015292 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025015294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 502025015295 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 502025015296 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 502025015297 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 502025015298 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 502025015299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025015300 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 502025015301 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025015302 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 502025015303 active site 502025015304 dimer interface [polypeptide binding]; other site 502025015305 metal binding site [ion binding]; metal-binding site 502025015306 Cupin domain; Region: Cupin_2; cl09118 502025015307 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 502025015308 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025015309 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025015310 putative active site [active] 502025015311 putative metal binding site [ion binding]; other site 502025015312 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 502025015313 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025015314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025015315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025015316 NAD(P) binding site [chemical binding]; other site 502025015317 active site 502025015318 transcriptional regulator; Provisional; Region: PRK10632 502025015319 Helix-turn-helix domains; Region: HTH; cl00088 502025015320 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025015321 putative effector binding pocket; other site 502025015322 dimerization interface [polypeptide binding]; other site 502025015323 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025015324 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 502025015325 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025015326 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 502025015327 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 502025015328 active site 502025015329 dimer interface [polypeptide binding]; other site 502025015330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015331 S-adenosylmethionine binding site [chemical binding]; other site 502025015332 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 502025015333 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025015334 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 502025015335 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 502025015336 putative active site [active] 502025015337 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 502025015338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015339 Walker A/P-loop; other site 502025015340 ATP binding site [chemical binding]; other site 502025015341 Q-loop/lid; other site 502025015342 ABC transporter signature motif; other site 502025015343 Walker B; other site 502025015344 D-loop; other site 502025015345 H-loop/switch region; other site 502025015346 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025015347 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025015348 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025015349 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 502025015350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025015351 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 502025015352 synthetase active site [active] 502025015353 NTP binding site [chemical binding]; other site 502025015354 metal binding site [ion binding]; metal-binding site 502025015355 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 502025015356 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 502025015357 AAA domain; Region: AAA_33; pfam13671 502025015358 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 502025015359 catalytic site [active] 502025015360 G-X2-G-X-G-K; other site 502025015361 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 502025015362 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 502025015363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015365 ATP binding site [chemical binding]; other site 502025015366 G-X-G motif; other site 502025015367 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015369 active site 502025015370 phosphorylation site [posttranslational modification] 502025015371 intermolecular recognition site; other site 502025015372 dimerization interface [polypeptide binding]; other site 502025015373 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 502025015374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015375 dimer interface [polypeptide binding]; other site 502025015376 phosphorylation site [posttranslational modification] 502025015377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015378 ATP binding site [chemical binding]; other site 502025015379 Mg2+ binding site [ion binding]; other site 502025015380 G-X-G motif; other site 502025015381 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025015382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015383 active site 502025015384 phosphorylation site [posttranslational modification] 502025015385 intermolecular recognition site; other site 502025015386 dimerization interface [polypeptide binding]; other site 502025015387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015388 Walker A motif; other site 502025015389 ATP binding site [chemical binding]; other site 502025015390 Walker B motif; other site 502025015391 arginine finger; other site 502025015392 Helix-turn-helix domains; Region: HTH; cl00088 502025015393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 502025015394 TraB family; Region: TraB; cl12050 502025015395 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 502025015396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025015397 FeS/SAM binding site; other site 502025015398 HEAT repeats; Region: HEAT_2; pfam13646 502025015399 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015400 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015401 active site 502025015402 ATP binding site [chemical binding]; other site 502025015403 substrate binding site [chemical binding]; other site 502025015404 activation loop (A-loop); other site 502025015405 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025015406 DNA translocase FtsK; Provisional; Region: PRK10263 502025015407 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025015408 thymidylate kinase; Validated; Region: tmk; PRK00698 502025015409 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 502025015410 TMP-binding site; other site 502025015411 ATP-binding site [chemical binding]; other site 502025015412 PilZ domain; Region: PilZ; cl01260 502025015413 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025015414 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025015415 catalytic residues [active] 502025015416 Bifunctional nuclease; Region: DNase-RNase; cl00553 502025015417 HEAT repeats; Region: HEAT_2; pfam13646 502025015418 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 502025015419 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015422 ATP binding site [chemical binding]; other site 502025015423 Mg2+ binding site [ion binding]; other site 502025015424 G-X-G motif; other site 502025015425 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025015426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015427 active site 502025015428 phosphorylation site [posttranslational modification] 502025015429 intermolecular recognition site; other site 502025015430 dimerization interface [polypeptide binding]; other site 502025015431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015432 Walker A motif; other site 502025015433 ATP binding site [chemical binding]; other site 502025015434 Walker B motif; other site 502025015435 arginine finger; other site 502025015436 Helix-turn-helix domains; Region: HTH; cl00088 502025015437 PspA/IM30 family; Region: PspA_IM30; pfam04012 502025015438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025015439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025015440 non-specific DNA binding site [nucleotide binding]; other site 502025015441 salt bridge; other site 502025015442 sequence-specific DNA binding site [nucleotide binding]; other site 502025015443 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 502025015444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025015445 FeS/SAM binding site; other site 502025015446 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 502025015447 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 502025015448 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 502025015449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025015450 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 502025015451 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 502025015452 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 502025015453 putative Iron-sulfur protein interface [polypeptide binding]; other site 502025015454 proximal heme binding site [chemical binding]; other site 502025015455 distal heme binding site [chemical binding]; other site 502025015456 putative dimer interface [polypeptide binding]; other site 502025015457 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 502025015458 dimer interface [polypeptide binding]; other site 502025015459 ADP-ribose binding site [chemical binding]; other site 502025015460 active site 502025015461 nudix motif; other site 502025015462 metal binding site [ion binding]; metal-binding site 502025015463 Membrane protein of unknown function; Region: DUF360; cl00850 502025015464 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 502025015465 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025015466 Protein phosphatase 2C; Region: PP2C; pfam00481 502025015467 active site 502025015468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015469 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015470 active site 502025015471 ATP binding site [chemical binding]; other site 502025015472 substrate binding site [chemical binding]; other site 502025015473 activation loop (A-loop); other site 502025015474 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025015475 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025015476 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 502025015477 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 502025015478 HIGH motif; other site 502025015479 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 502025015480 active site 502025015481 KMSKS motif; other site 502025015482 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 502025015483 tRNA binding surface [nucleotide binding]; other site 502025015484 anticodon binding site; other site 502025015485 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 502025015486 active site 502025015487 DNA polymerase IV; Validated; Region: PRK02406 502025015488 DNA binding site [nucleotide binding] 502025015489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025015490 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025015491 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 502025015492 active site 502025015493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025015494 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025015495 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 502025015496 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 502025015497 substrate binding site [chemical binding]; other site 502025015498 active site 502025015499 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025015500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015501 active site 502025015502 phosphorylation site [posttranslational modification] 502025015503 intermolecular recognition site; other site 502025015504 dimerization interface [polypeptide binding]; other site 502025015505 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 502025015506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025015507 DNA binding residues [nucleotide binding] 502025015508 dimerization interface [polypeptide binding]; other site 502025015509 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 502025015510 PilZ domain; Region: PilZ; cl01260 502025015511 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 502025015512 Predicted transcriptional regulators [Transcription]; Region: COG1510 502025015513 Bacterial Ig-like domain; Region: Big_5; cl01012 502025015514 recombinase A; Provisional; Region: recA; PRK09354 502025015515 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 502025015516 hexamer interface [polypeptide binding]; other site 502025015517 Walker A motif; other site 502025015518 ATP binding site [chemical binding]; other site 502025015519 Walker B motif; other site 502025015520 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 502025015521 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 502025015522 competence damage-inducible protein A; Provisional; Region: PRK00549 502025015523 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 502025015524 putative MPT binding site; other site 502025015525 Competence-damaged protein; Region: CinA; cl00666 502025015526 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025015527 active site 502025015528 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 502025015529 metal binding site 2 [ion binding]; metal-binding site 502025015530 putative DNA binding helix; other site 502025015531 metal binding site 1 [ion binding]; metal-binding site 502025015532 dimer interface [polypeptide binding]; other site 502025015533 structural Zn2+ binding site [ion binding]; other site 502025015534 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 502025015535 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015537 active site 502025015538 phosphorylation site [posttranslational modification] 502025015539 intermolecular recognition site; other site 502025015540 dimerization interface [polypeptide binding]; other site 502025015541 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 502025015542 substrate binding pocket [chemical binding]; other site 502025015543 chain length determination region; other site 502025015544 catalytic residues [active] 502025015545 substrate-Mg2+ binding site; other site 502025015546 aspartate-rich region 1; other site 502025015547 active site lid residues [active] 502025015548 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025015549 structural tetrad; other site 502025015550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015551 phosphopeptide binding site; other site 502025015552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025015553 metal binding site [ion binding]; metal-binding site 502025015554 active site 502025015555 I-site; other site 502025015556 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 502025015558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025015559 catalytic residue [active] 502025015560 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025015561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015562 putative active site [active] 502025015563 heme pocket [chemical binding]; other site 502025015564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015565 dimer interface [polypeptide binding]; other site 502025015566 phosphorylation site [posttranslational modification] 502025015567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015568 ATP binding site [chemical binding]; other site 502025015569 Mg2+ binding site [ion binding]; other site 502025015570 G-X-G motif; other site 502025015571 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015573 active site 502025015574 phosphorylation site [posttranslational modification] 502025015575 intermolecular recognition site; other site 502025015576 dimerization interface [polypeptide binding]; other site 502025015577 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 502025015578 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 502025015579 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025015580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025015581 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025015582 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 502025015583 Clp amino terminal domain; Region: Clp_N; pfam02861 502025015584 Clp amino terminal domain; Region: Clp_N; pfam02861 502025015585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015586 Walker A motif; other site 502025015587 ATP binding site [chemical binding]; other site 502025015588 Walker B motif; other site 502025015589 arginine finger; other site 502025015590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015591 Walker A motif; other site 502025015592 ATP binding site [chemical binding]; other site 502025015593 Walker B motif; other site 502025015594 arginine finger; other site 502025015595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025015596 chaperone protein DnaJ; Provisional; Region: PRK10767 502025015597 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025015598 HSP70 interaction site [polypeptide binding]; other site 502025015599 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025015600 dimer interface [polypeptide binding]; other site 502025015601 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025015602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015603 Walker A motif; other site 502025015604 ATP binding site [chemical binding]; other site 502025015605 Walker B motif; other site 502025015606 arginine finger; other site 502025015607 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025015608 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025015609 catalytic residues [active] 502025015610 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 502025015611 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 502025015612 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 502025015613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 502025015614 rod shape-determining protein MreC; Region: MreC; pfam04085 502025015615 rod shape-determining protein MreB; Provisional; Region: PRK13927 502025015616 Cell division protein FtsA; Region: FtsA; cl11496 502025015617 SurA N-terminal domain; Region: SurA_N_3; cl07813 502025015618 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 502025015619 PPIC-type PPIASE domain; Region: Rotamase; cl08278 502025015620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025015621 dimer interface [polypeptide binding]; other site 502025015622 conserved gate region; other site 502025015623 putative PBP binding loops; other site 502025015624 ABC-ATPase subunit interface; other site 502025015625 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 502025015626 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 502025015627 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 502025015628 Walker A/P-loop; other site 502025015629 ATP binding site [chemical binding]; other site 502025015630 Q-loop/lid; other site 502025015631 ABC transporter signature motif; other site 502025015632 Walker B; other site 502025015633 D-loop; other site 502025015634 H-loop/switch region; other site 502025015635 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 502025015636 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 502025015637 Walker A/P-loop; other site 502025015638 ATP binding site [chemical binding]; other site 502025015639 Q-loop/lid; other site 502025015640 ABC transporter signature motif; other site 502025015641 Walker B; other site 502025015642 D-loop; other site 502025015643 H-loop/switch region; other site 502025015644 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 502025015645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025015646 dimer interface [polypeptide binding]; other site 502025015647 conserved gate region; other site 502025015648 putative PBP binding loops; other site 502025015649 ABC-ATPase subunit interface; other site 502025015650 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025015651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025015652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025015653 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025015654 Disintegrin; Region: Disintegrin; cl10507 502025015655 Bacterial Ig-like domain; Region: Big_5; cl01012 502025015656 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 502025015657 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 502025015658 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 502025015659 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 502025015660 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 502025015661 Ligand binding site; other site 502025015662 oligomer interface; other site 502025015663 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 502025015664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025015665 active site 502025015666 motif I; other site 502025015667 motif II; other site 502025015668 NeuB family; Region: NeuB; cl00496 502025015669 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 502025015670 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 502025015671 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025015672 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025015673 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 502025015674 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 502025015675 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 502025015676 Walker A/P-loop; other site 502025015677 ATP binding site [chemical binding]; other site 502025015678 Q-loop/lid; other site 502025015679 ABC transporter signature motif; other site 502025015680 Walker B; other site 502025015681 D-loop; other site 502025015682 H-loop/switch region; other site 502025015683 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025015684 KpsF/GutQ family protein; Region: kpsF; TIGR00393 502025015685 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 502025015686 putative active site [active] 502025015687 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025015688 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015689 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015690 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015691 Transposase [DNA replication, recombination, and repair]; Region: COG5421 502025015692 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 502025015693 active site 502025015694 nucleophile elbow; other site 502025015695 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025015696 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 502025015697 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025015698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015699 Walker A motif; other site 502025015700 ATP binding site [chemical binding]; other site 502025015701 Walker B motif; other site 502025015702 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 502025015703 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 502025015704 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025015705 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025015706 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025015707 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025015708 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 502025015709 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025015710 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 502025015711 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 502025015712 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025015713 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025015714 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025015715 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 502025015716 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025015717 guanine deaminase; Provisional; Region: PRK09228 502025015718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025015719 active site 502025015720 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025015721 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 502025015722 TfoX N-terminal domain; Region: TfoX_N; cl01167 502025015723 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 502025015724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015725 S-adenosylmethionine binding site [chemical binding]; other site 502025015726 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 502025015727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015728 Walker A motif; other site 502025015729 ATP binding site [chemical binding]; other site 502025015730 Walker B motif; other site 502025015731 arginine finger; other site 502025015732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015733 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015734 active site 502025015735 ATP binding site [chemical binding]; other site 502025015736 substrate binding site [chemical binding]; other site 502025015737 activation loop (A-loop); other site 502025015738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015739 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015740 conserved hypothetical protein; Region: QEGLA; TIGR02421 502025015741 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 502025015742 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 502025015743 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025015744 SNF2 Helicase protein; Region: DUF3670; pfam12419 502025015745 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025015746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025015747 ATP binding site [chemical binding]; other site 502025015748 putative Mg++ binding site [ion binding]; other site 502025015749 Peptidase family M48; Region: Peptidase_M48; cl12018 502025015750 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025015751 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 502025015752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025015753 dimerization interface [polypeptide binding]; other site 502025015754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015755 dimer interface [polypeptide binding]; other site 502025015756 phosphorylation site [posttranslational modification] 502025015757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015758 ATP binding site [chemical binding]; other site 502025015759 Mg2+ binding site [ion binding]; other site 502025015760 G-X-G motif; other site 502025015761 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025015762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015763 active site 502025015764 phosphorylation site [posttranslational modification] 502025015765 intermolecular recognition site; other site 502025015766 dimerization interface [polypeptide binding]; other site 502025015767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025015768 Walker A motif; other site 502025015769 ATP binding site [chemical binding]; other site 502025015770 Walker B motif; other site 502025015771 arginine finger; other site 502025015772 Helix-turn-helix domains; Region: HTH; cl00088 502025015773 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 502025015774 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025015775 Cu(I) binding site [ion binding]; other site 502025015776 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 502025015777 Domain of unknown function (DUF368); Region: DUF368; cl00893 502025015778 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 502025015779 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025015780 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025015781 Low molecular weight phosphatase family; Region: LMWPc; cl00105 502025015782 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 502025015783 active site 502025015784 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 502025015785 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025015786 PilZ domain; Region: PilZ; cl01260 502025015787 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015789 active site 502025015790 phosphorylation site [posttranslational modification] 502025015791 intermolecular recognition site; other site 502025015792 dimerization interface [polypeptide binding]; other site 502025015793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 502025015794 active site 502025015795 phosphorylation site [posttranslational modification] 502025015796 intermolecular recognition site; other site 502025015797 dimerization interface [polypeptide binding]; other site 502025015798 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 502025015799 proline aminopeptidase P II; Provisional; Region: PRK10879 502025015800 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 502025015801 active site 502025015802 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 502025015803 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 502025015804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015805 active site 502025015806 phosphorylation site [posttranslational modification] 502025015807 intermolecular recognition site; other site 502025015808 dimerization interface [polypeptide binding]; other site 502025015809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025015810 DNA binding site [nucleotide binding] 502025015811 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025015812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025015813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015814 dimer interface [polypeptide binding]; other site 502025015815 phosphorylation site [posttranslational modification] 502025015816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015817 ATP binding site [chemical binding]; other site 502025015818 Mg2+ binding site [ion binding]; other site 502025015819 G-X-G motif; other site 502025015820 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 502025015821 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 502025015822 FMN binding site [chemical binding]; other site 502025015823 active site 502025015824 catalytic residues [active] 502025015825 substrate binding site [chemical binding]; other site 502025015826 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 502025015827 GTP binding site; other site 502025015828 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 502025015829 active site 502025015830 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 502025015831 active site 502025015832 dimerization interface [polypeptide binding]; other site 502025015833 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 502025015834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025015835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025015836 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025015837 PilZ domain; Region: PilZ; cl01260 502025015838 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 502025015839 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025015840 putative active site [active] 502025015841 putative metal binding site [ion binding]; other site 502025015842 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 502025015843 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025015844 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025015845 catalytic residue [active] 502025015846 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 502025015847 Cytochrome P450; Region: p450; pfam00067 502025015848 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 502025015849 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025015850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025015851 catalytic residue [active] 502025015852 FcoT-like thioesterase domain; Region: FcoT; pfam10862 502025015853 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 502025015854 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 502025015855 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 502025015856 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025015857 Helix-turn-helix domains; Region: HTH; cl00088 502025015858 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025015859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015861 active site 502025015862 ATP binding site [chemical binding]; other site 502025015863 substrate binding site [chemical binding]; other site 502025015864 activation loop (A-loop); other site 502025015865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015866 Erythromycin esterase; Region: Erythro_esteras; pfam05139 502025015867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015868 binding surface 502025015869 TPR motif; other site 502025015870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015871 GAF domain; Region: GAF; cl15785 502025015872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015874 dimer interface [polypeptide binding]; other site 502025015875 phosphorylation site [posttranslational modification] 502025015876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015877 ATP binding site [chemical binding]; other site 502025015878 Mg2+ binding site [ion binding]; other site 502025015879 G-X-G motif; other site 502025015880 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 502025015881 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025015882 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025015883 protein binding site [polypeptide binding]; other site 502025015884 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 502025015885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015886 Family description; Region: UvrD_C_2; cl15862 502025015887 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025015888 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025015889 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025015890 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025015891 TPR repeat; Region: TPR_11; pfam13414 502025015892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015893 binding surface 502025015894 TPR motif; other site 502025015895 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015896 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 502025015897 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025015898 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 502025015899 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 502025015900 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 502025015901 dimerization interface [polypeptide binding]; other site 502025015902 active site 502025015903 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 502025015904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025015905 motif II; other site 502025015906 CAAX protease self-immunity; Region: Abi; cl00558 502025015907 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 502025015908 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 502025015909 putative active site; other site 502025015910 catalytic residue [active] 502025015911 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 502025015912 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 502025015913 active site 502025015914 metal binding site [ion binding]; metal-binding site 502025015915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025015916 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 502025015917 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025015918 Beta propeller domain; Region: Beta_propel; pfam09826 502025015919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015920 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015921 active site 502025015922 ATP binding site [chemical binding]; other site 502025015923 substrate binding site [chemical binding]; other site 502025015924 activation loop (A-loop); other site 502025015925 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025015926 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025015927 Ligase N family; Region: LIGANc; smart00532 502025015928 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 502025015929 nucleotide binding pocket [chemical binding]; other site 502025015930 K-X-D-G motif; other site 502025015931 catalytic site [active] 502025015932 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 502025015933 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 502025015934 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 502025015935 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 502025015936 Dimer interface [polypeptide binding]; other site 502025015937 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025015938 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025015939 active site 502025015940 phosphorylation site [posttranslational modification] 502025015941 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 502025015942 active site 502025015943 NTP binding site [chemical binding]; other site 502025015944 metal binding triad [ion binding]; metal-binding site 502025015945 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 502025015946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015947 S-adenosylmethionine binding site [chemical binding]; other site 502025015948 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 502025015949 glycogen binding site [chemical binding]; other site 502025015950 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025015951 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 502025015952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015954 active site 502025015955 ATP binding site [chemical binding]; other site 502025015956 substrate binding site [chemical binding]; other site 502025015957 activation loop (A-loop); other site 502025015958 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 502025015959 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025015960 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025015961 ABC transporter; Region: ABC_tran_2; pfam12848 502025015962 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025015963 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 502025015964 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 502025015965 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 502025015966 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 502025015967 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 502025015968 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 502025015969 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 502025015970 alpha subunit interaction interface [polypeptide binding]; other site 502025015971 Walker A motif; other site 502025015972 ATP binding site [chemical binding]; other site 502025015973 Walker B motif; other site 502025015974 inhibitor binding site; inhibition site 502025015975 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 502025015976 ATP synthase; Region: ATP-synt; cl00365 502025015977 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 502025015978 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 502025015979 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 502025015980 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 502025015981 beta subunit interaction interface [polypeptide binding]; other site 502025015982 Walker A motif; other site 502025015983 ATP binding site [chemical binding]; other site 502025015984 Walker B motif; other site 502025015985 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 502025015986 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025015987 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 502025015988 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 502025015989 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025015990 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 502025015991 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 502025015992 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 502025015993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015994 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015995 active site 502025015996 ATP binding site [chemical binding]; other site 502025015997 substrate binding site [chemical binding]; other site 502025015998 activation loop (A-loop); other site 502025015999 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025016000 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025016001 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016003 active site 502025016004 phosphorylation site [posttranslational modification] 502025016005 intermolecular recognition site; other site 502025016006 dimerization interface [polypeptide binding]; other site 502025016007 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 502025016008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025016009 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025016010 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 502025016011 NAD binding site [chemical binding]; other site 502025016012 putative substrate binding site 2 [chemical binding]; other site 502025016013 putative substrate binding site 1 [chemical binding]; other site 502025016014 active site 502025016015 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 502025016016 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 502025016017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016018 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 502025016019 putative NAD(P) binding site [chemical binding]; other site 502025016020 dimer interface [polypeptide binding]; other site 502025016021 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025016022 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025016023 Ciliary basal body-associated, B9 protein; Region: B9-C2; pfam07162 502025016024 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 502025016025 ABC-2 type transporter; Region: ABC2_membrane; cl11417 502025016026 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 502025016027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016028 Walker A/P-loop; other site 502025016029 ATP binding site [chemical binding]; other site 502025016030 Q-loop/lid; other site 502025016031 ABC transporter signature motif; other site 502025016032 Walker B; other site 502025016033 D-loop; other site 502025016034 H-loop/switch region; other site 502025016035 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 502025016036 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 502025016037 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025016038 active site 502025016039 catalytic site [active] 502025016040 substrate binding site [chemical binding]; other site 502025016041 tetratricopeptide repeat protein; Provisional; Region: PRK11788 502025016042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016043 active site 502025016044 ATP binding site [chemical binding]; other site 502025016045 substrate binding site [chemical binding]; other site 502025016046 activation loop (A-loop); other site 502025016047 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025016048 AAA domain; Region: AAA_28; pfam13521 502025016049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016050 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 502025016051 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016052 active site 502025016053 ATP binding site [chemical binding]; other site 502025016054 substrate binding site [chemical binding]; other site 502025016055 activation loop (A-loop); other site 502025016056 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 502025016057 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 502025016058 active site 502025016059 catalytic motif [active] 502025016060 Zn binding site [ion binding]; other site 502025016061 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 502025016062 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 502025016063 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025016064 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025016065 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 502025016066 Sulfatase; Region: Sulfatase; cl10460 502025016067 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 502025016068 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 502025016069 intersubunit interface [polypeptide binding]; other site 502025016070 active site 502025016071 catalytic residue [active] 502025016072 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025016073 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025016074 active site 502025016075 catalytic tetrad [active] 502025016076 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 502025016077 glutathione s-transferase; Provisional; Region: PTZ00057 502025016078 GSH binding site (G-site) [chemical binding]; other site 502025016079 C-terminal domain interface [polypeptide binding]; other site 502025016080 dimer interface [polypeptide binding]; other site 502025016081 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025016082 N-terminal domain interface [polypeptide binding]; other site 502025016083 dimer interface [polypeptide binding]; other site 502025016084 substrate binding pocket (H-site) [chemical binding]; other site 502025016085 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 502025016086 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 502025016087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016088 NAD(P) binding site [chemical binding]; other site 502025016089 active site 502025016090 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 502025016091 Site-specific recombinase; Region: SpecificRecomb; cl15411 502025016092 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025016093 dimer interface [polypeptide binding]; other site 502025016094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025016095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025016096 active site 502025016097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025016098 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025016099 active site 502025016100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 502025016101 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 502025016102 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025016103 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025016104 ABC transporter; Region: ABC_tran_2; pfam12848 502025016105 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 502025016106 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025016107 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 502025016108 DNA topoisomerase III; Provisional; Region: PRK07726 502025016109 active site 502025016110 putative interdomain interaction site [polypeptide binding]; other site 502025016111 putative metal-binding site [ion binding]; other site 502025016112 putative nucleotide binding site [chemical binding]; other site 502025016113 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 502025016114 domain I; other site 502025016115 phosphate binding site [ion binding]; other site 502025016116 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 502025016117 domain II; other site 502025016118 domain III; other site 502025016119 nucleotide binding site [chemical binding]; other site 502025016120 DNA binding groove [nucleotide binding] 502025016121 catalytic site [active] 502025016122 domain IV; other site 502025016123 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 502025016124 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 502025016125 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 502025016126 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 502025016127 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025016128 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 502025016129 Cupin domain; Region: Cupin_2; cl09118 502025016130 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 502025016131 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016132 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016133 metal ion-dependent adhesion site (MIDAS); other site 502025016134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025016135 PAS fold; Region: PAS_4; pfam08448 502025016136 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025016137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025016138 dimer interface [polypeptide binding]; other site 502025016139 phosphorylation site [posttranslational modification] 502025016140 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016142 active site 502025016143 phosphorylation site [posttranslational modification] 502025016144 intermolecular recognition site; other site 502025016145 dimerization interface [polypeptide binding]; other site 502025016146 Protein of unknown function (DUF523); Region: DUF523; cl00733 502025016147 Acetokinase family; Region: Acetate_kinase; cl01029 502025016148 acetate kinase; Region: ackA; TIGR00016 502025016149 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 502025016150 Propanediol utilisation protein PduL; Region: PduL; pfam06130 502025016151 Propanediol utilisation protein PduL; Region: PduL; pfam06130 502025016152 probable methyltransferase; Region: TIGR03438 502025016153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025016154 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 502025016155 TIGR03440 family protein; Region: unchr_TIGR03440 502025016156 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025016157 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 502025016158 putative nucleotide binding site [chemical binding]; other site 502025016159 uridine monophosphate binding site [chemical binding]; other site 502025016160 homohexameric interface [polypeptide binding]; other site 502025016161 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025016162 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 502025016163 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 502025016164 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 502025016165 active site 502025016166 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025016167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016170 active site 502025016171 ATP binding site [chemical binding]; other site 502025016172 substrate binding site [chemical binding]; other site 502025016173 activation loop (A-loop); other site 502025016174 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 502025016175 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025016176 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025016177 catalytic triad [active] 502025016178 putative active site [active] 502025016179 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 502025016180 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025016181 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025016182 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 502025016183 starch binding outer membrane protein SusD; Region: SusD; cd08977 502025016184 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 502025016185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025016186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025016187 DNA binding residues [nucleotide binding] 502025016188 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 502025016189 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 502025016190 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025016191 active site 502025016192 catalytic site [active] 502025016193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016194 Walker A/P-loop; other site 502025016195 ATP binding site [chemical binding]; other site 502025016196 Q-loop/lid; other site 502025016197 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 502025016198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016199 Walker B; other site 502025016200 D-loop; other site 502025016201 H-loop/switch region; other site 502025016202 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 502025016203 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 502025016204 active site 502025016205 metal binding site [ion binding]; metal-binding site 502025016206 DNA binding site [nucleotide binding] 502025016207 HerA helicase [Replication, recombination, and repair]; Region: COG0433 502025016208 NurA domain; Region: NurA; cl09134 502025016209 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025016210 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025016211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025016212 Helix-turn-helix domains; Region: HTH; cl00088 502025016213 WHG domain; Region: WHG; pfam13305 502025016214 short chain dehydrogenase; Provisional; Region: PRK06197 502025016215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016216 NAD(P) binding site [chemical binding]; other site 502025016217 active site 502025016218 acetyl-CoA synthetase; Provisional; Region: PRK00174 502025016219 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 502025016220 AMP-binding enzyme; Region: AMP-binding; cl15778 502025016221 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016222 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 502025016223 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 502025016224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025016225 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 502025016226 active site 502025016227 iron coordination sites [ion binding]; other site 502025016228 substrate binding pocket [chemical binding]; other site 502025016229 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 502025016230 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025016231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025016232 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025016233 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025016234 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 502025016235 homodimer interface [polypeptide binding]; other site 502025016236 substrate-cofactor binding pocket; other site 502025016237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025016238 catalytic residue [active] 502025016239 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025016240 putative ligand binding site [chemical binding]; other site 502025016241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016242 ATP-grasp domain; Region: ATP-grasp_4; cl03087 502025016243 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 502025016244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025016245 Coenzyme A binding pocket [chemical binding]; other site 502025016246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025016247 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025016248 putative substrate translocation pore; other site 502025016249 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025016250 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 502025016251 active site 502025016252 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 502025016253 Predicted acetyltransferase [General function prediction only]; Region: COG3153 502025016254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025016255 Coenzyme A binding pocket [chemical binding]; other site 502025016256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 502025016257 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025016258 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025016259 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 502025016260 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 502025016261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025016262 inhibitor-cofactor binding pocket; inhibition site 502025016263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025016264 catalytic residue [active] 502025016265 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 502025016266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016267 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 502025016268 substrate binding site [chemical binding]; other site 502025016269 B12 cofactor binding site [chemical binding]; other site 502025016270 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 502025016271 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 502025016272 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025016273 nucleotide binding site [chemical binding]; other site 502025016274 substrate binding site [chemical binding]; other site 502025016275 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025016276 B12 binding site [chemical binding]; other site 502025016277 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025016278 putative di-iron ligands [ion binding]; other site 502025016279 acyl-CoA synthetase; Validated; Region: PRK05850 502025016280 AMP-binding enzyme; Region: AMP-binding; cl15778 502025016281 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025016282 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 502025016283 thioester reductase domain; Region: Thioester-redct; TIGR01746 502025016284 putative NAD(P) binding site [chemical binding]; other site 502025016285 active site 502025016286 putative substrate binding site [chemical binding]; other site 502025016287 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 502025016288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016289 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 502025016290 Integrase core domain; Region: rve; cl01316 502025016291 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 502025016292 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 502025016293 cysteine synthase B; Region: cysM; TIGR01138 502025016294 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025016295 dimer interface [polypeptide binding]; other site 502025016296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025016297 catalytic residue [active] 502025016298 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 502025016299 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 502025016300 conserved cys residue [active] 502025016301 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 502025016302 active site 502025016303 catalytic residues [active] 502025016304 metal binding site [ion binding]; metal-binding site 502025016305 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 502025016306 active site 502025016307 Family description; Region: VCBS; pfam13517 502025016308 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 502025016309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016310 Walker A motif; other site 502025016311 ATP binding site [chemical binding]; other site 502025016312 Walker B motif; other site 502025016313 arginine finger; other site 502025016314 Helix-turn-helix domains; Region: HTH; cl00088 502025016315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016316 active site 502025016317 ATP binding site [chemical binding]; other site 502025016318 substrate binding site [chemical binding]; other site 502025016319 activation loop (A-loop); other site 502025016320 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016321 substrate binding site [chemical binding]; other site 502025016322 activation loop (A-loop); other site 502025016323 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016325 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 502025016326 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 502025016327 glycogen synthase; Provisional; Region: glgA; PRK00654 502025016328 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 502025016329 ADP-binding pocket [chemical binding]; other site 502025016330 homodimer interface [polypeptide binding]; other site 502025016331 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025016332 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025016333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025016334 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 502025016335 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 502025016336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025016337 active site 502025016338 metal binding site [ion binding]; metal-binding site 502025016339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025016340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025016341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025016342 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 502025016343 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025016344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025016345 catalytic residue [active] 502025016346 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025016347 translation initiation factor IF-2; Region: IF-2; TIGR00487 502025016348 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025016349 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 502025016350 G1 box; other site 502025016351 putative GEF interaction site [polypeptide binding]; other site 502025016352 GTP/Mg2+ binding site [chemical binding]; other site 502025016353 Switch I region; other site 502025016354 G2 box; other site 502025016355 G3 box; other site 502025016356 Switch II region; other site 502025016357 G4 box; other site 502025016358 G5 box; other site 502025016359 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 502025016360 Translation-initiation factor 2; Region: IF-2; pfam11987 502025016361 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 502025016362 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 502025016363 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 502025016364 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016365 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016366 active site 502025016367 ATP binding site [chemical binding]; other site 502025016368 substrate binding site [chemical binding]; other site 502025016369 activation loop (A-loop); other site 502025016370 Predicted ATPase [General function prediction only]; Region: COG3899 502025016371 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025016372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025016373 DNA binding residues [nucleotide binding] 502025016374 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025016375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025016376 classical (c) SDRs; Region: SDR_c; cd05233 502025016377 NAD(P) binding site [chemical binding]; other site 502025016378 active site 502025016379 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 502025016380 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 502025016381 Predicted peptidase [General function prediction only]; Region: COG4099 502025016382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016384 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016385 active site 502025016386 ATP binding site [chemical binding]; other site 502025016387 substrate binding site [chemical binding]; other site 502025016388 activation loop (A-loop); other site 502025016389 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016390 Predicted ATPase [General function prediction only]; Region: COG3899 502025016391 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025016392 GAF domain; Region: GAF; cl15785 502025016393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016394 dimer interface [polypeptide binding]; other site 502025016395 phosphorylation site [posttranslational modification] 502025016396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016397 ATP binding site [chemical binding]; other site 502025016398 Mg2+ binding site [ion binding]; other site 502025016399 G-X-G motif; other site 502025016400 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016402 active site 502025016403 phosphorylation site [posttranslational modification] 502025016404 intermolecular recognition site; other site 502025016405 dimerization interface [polypeptide binding]; other site 502025016406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025016407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016408 S-adenosylmethionine binding site [chemical binding]; other site 502025016409 NlpC/P60 family; Region: NLPC_P60; cl11438 502025016410 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025016411 Protein export membrane protein; Region: SecD_SecF; cl14618 502025016412 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025016413 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016414 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016415 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 502025016416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025016417 Helix-turn-helix domains; Region: HTH; cl00088 502025016418 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 502025016419 hydrophobic ligand binding site; other site 502025016420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016421 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 502025016422 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 502025016423 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 502025016424 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025016425 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025016426 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025016427 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016428 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016429 active site 502025016430 ATP binding site [chemical binding]; other site 502025016431 substrate binding site [chemical binding]; other site 502025016432 activation loop (A-loop); other site 502025016433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016435 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025016436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025016437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025016438 DNA binding residues [nucleotide binding] 502025016439 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025016440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025016441 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 502025016442 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025016443 homodimer interface [polypeptide binding]; other site 502025016444 ligand binding site I [chemical binding]; other site 502025016445 Ca binding site [ion binding]; other site 502025016446 ligand binding site II [chemical binding]; other site 502025016447 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 502025016448 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 502025016449 active site flap/lid [active] 502025016450 nucleophilic elbow; other site 502025016451 catalytic triad [active] 502025016452 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025016453 active site 502025016454 catalytic residues [active] 502025016455 Protein of unknown function (DUF732); Region: DUF732; pfam05305 502025016456 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025016457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025016458 Predicted transcriptional regulator [Transcription]; Region: COG1959 502025016459 Helix-turn-helix domains; Region: HTH; cl00088 502025016460 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025016461 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025016462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016463 active site 502025016464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025016465 phosphorylation site [posttranslational modification] 502025016466 intermolecular recognition site; other site 502025016467 dimerization interface [polypeptide binding]; other site 502025016468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016469 dimer interface [polypeptide binding]; other site 502025016470 phosphorylation site [posttranslational modification] 502025016471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016472 ATP binding site [chemical binding]; other site 502025016473 Mg2+ binding site [ion binding]; other site 502025016474 G-X-G motif; other site 502025016475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016476 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016477 active site 502025016478 phosphorylation site [posttranslational modification] 502025016479 intermolecular recognition site; other site 502025016480 dimerization interface [polypeptide binding]; other site 502025016481 PAAR motif; Region: PAAR_motif; cl15808 502025016482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025016483 Predicted permease; Region: DUF318; pfam03773 502025016484 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025016485 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 502025016486 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 502025016487 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 502025016488 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025016489 DNA binding site [nucleotide binding] 502025016490 active site 502025016491 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 502025016492 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 502025016493 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 502025016494 PKC phosphorylation site [posttranslational modification]; other site 502025016495 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 502025016496 putative active site [active] 502025016497 putative metal binding site [ion binding]; other site 502025016498 SWIM zinc finger; Region: SWIM; cl15408 502025016499 SNF2 Helicase protein; Region: DUF3670; pfam12419 502025016500 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025016501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025016502 ATP binding site [chemical binding]; other site 502025016503 putative Mg++ binding site [ion binding]; other site 502025016504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025016505 nucleotide binding region [chemical binding]; other site 502025016506 ATP-binding site [chemical binding]; other site 502025016507 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025016508 protein-splicing catalytic site; other site 502025016509 thioester formation/cholesterol transfer; other site 502025016510 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025016511 protein-splicing catalytic site; other site 502025016512 thioester formation/cholesterol transfer; other site 502025016513 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025016514 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025016515 calcium binding site 2 [ion binding]; other site 502025016516 active site 502025016517 catalytic triad [active] 502025016518 calcium binding site 1 [ion binding]; other site 502025016519 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025016520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025016521 thioester formation/cholesterol transfer; other site 502025016522 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025016523 catalytic residues [active] 502025016524 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025016525 catalytic residues [active] 502025016526 Uncharacterized conserved protein [Function unknown]; Region: COG5276 502025016527 LVIVD repeat; Region: LVIVD; pfam08309 502025016528 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 502025016529 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025016530 catalytic residues [active] 502025016531 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025016532 RHS Repeat; Region: RHS_repeat; cl11982 502025016533 RHS Repeat; Region: RHS_repeat; cl11982 502025016534 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025016535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025016536 DNA binding residues [nucleotide binding] 502025016537 HYR domain; Region: HYR; pfam02494 502025016538 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 502025016539 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 502025016540 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 502025016541 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 502025016542 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 502025016543 chaperone protein DnaJ; Provisional; Region: PRK14294 502025016544 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 502025016545 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 502025016546 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 502025016547 metal binding site [ion binding]; metal-binding site 502025016548 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 502025016549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016550 S-adenosylmethionine binding site [chemical binding]; other site 502025016551 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025016552 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025016553 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 502025016554 HupE / UreJ protein; Region: HupE_UreJ; cl01011 502025016555 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025016556 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025016557 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 502025016558 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 502025016559 dimer interface [polypeptide binding]; other site 502025016560 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 502025016561 active site 502025016562 Fe binding site [ion binding]; other site 502025016563 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 502025016564 AMP-binding enzyme; Region: AMP-binding; cl15778 502025016565 AMP-binding enzyme; Region: AMP-binding; cl15778 502025016566 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025016567 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 502025016568 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 502025016569 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025016570 active site 502025016571 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 502025016572 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025016573 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 502025016574 active site 502025016575 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 502025016576 Membrane transport protein; Region: Mem_trans; cl09117 502025016577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025016578 dimerization interface [polypeptide binding]; other site 502025016579 putative DNA binding site [nucleotide binding]; other site 502025016580 putative Zn2+ binding site [ion binding]; other site 502025016581 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025016582 phosphopeptide binding site; other site 502025016583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016584 NmrA-like family; Region: NmrA; pfam05368 502025016585 NAD(P) binding site [chemical binding]; other site 502025016586 active site 502025016587 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016588 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016589 active site 502025016590 ATP binding site [chemical binding]; other site 502025016591 substrate binding site [chemical binding]; other site 502025016592 activation loop (A-loop); other site 502025016593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016594 Predicted ATPase [General function prediction only]; Region: COG3899 502025016595 Uncharacterized conserved protein [Function unknown]; Region: COG1944 502025016596 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 502025016597 Uncharacterized conserved protein [Function unknown]; Region: COG3482 502025016598 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 502025016599 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 502025016600 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 502025016601 active site 502025016602 Zn binding site [ion binding]; other site 502025016603 Helix-turn-helix domains; Region: HTH; cl00088 502025016604 LysR family transcriptional regulator; Provisional; Region: PRK14997 502025016605 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025016606 putative effector binding pocket; other site 502025016607 dimerization interface [polypeptide binding]; other site 502025016608 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 502025016609 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 502025016610 potential catalytic triad [active] 502025016611 conserved cys residue [active] 502025016612 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025016613 classical (c) SDRs; Region: SDR_c; cd05233 502025016614 NAD(P) binding site [chemical binding]; other site 502025016615 active site 502025016616 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025016617 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 502025016618 GSH binding site (G-site) [chemical binding]; other site 502025016619 C-terminal domain interface [polypeptide binding]; other site 502025016620 dimer interface [polypeptide binding]; other site 502025016621 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025016622 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025016623 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 502025016624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025016625 N-terminal plug; other site 502025016626 ligand-binding site [chemical binding]; other site 502025016627 putative chaperone; Provisional; Region: PRK11678 502025016628 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 502025016629 Endonuclease I; Region: Endonuclease_1; cl01003 502025016630 Clp protease; Region: CLP_protease; pfam00574 502025016631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 502025016632 oligomer interface [polypeptide binding]; other site 502025016633 active site residues [active] 502025016634 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 502025016635 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 502025016636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 502025016637 substrate binding site [chemical binding]; other site 502025016638 ATP binding site [chemical binding]; other site 502025016639 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 502025016640 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016642 active site 502025016643 substrate binding site [chemical binding]; other site 502025016644 ATP binding site [chemical binding]; other site 502025016645 activation loop (A-loop); other site 502025016646 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016647 metal ion-dependent adhesion site (MIDAS); other site 502025016648 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025016649 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025016650 Putative esterase; Region: Esterase; pfam00756 502025016651 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 502025016652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016653 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 502025016654 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 502025016655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025016656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025016657 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 502025016658 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 502025016659 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016660 Walker A motif; other site 502025016661 ATP binding site [chemical binding]; other site 502025016662 Walker B motif; other site 502025016663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025016664 Helix-turn-helix domains; Region: HTH; cl00088 502025016665 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 502025016666 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016667 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025016668 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016669 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025016670 Protein export membrane protein; Region: SecD_SecF; cl14618 502025016671 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025016672 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025016673 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016674 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025016675 Rhomboid family; Region: Rhomboid; cl11446 502025016676 Rhomboid family; Region: Rhomboid; cl11446 502025016677 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 502025016678 N-carbamolyputrescine amidase; Region: PLN02747 502025016679 putative active site; other site 502025016680 catalytic triad [active] 502025016681 putative dimer interface [polypeptide binding]; other site 502025016682 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 502025016683 agmatine deiminase; Region: agmatine_aguA; TIGR03380 502025016684 Family description; Region: VCBS; pfam13517 502025016685 Family description; Region: VCBS; pfam13517 502025016686 Family description; Region: VCBS; pfam13517 502025016687 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 502025016688 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 502025016689 active site 502025016690 DNA binding site [nucleotide binding] 502025016691 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 502025016692 DNA binding site [nucleotide binding] 502025016693 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025016694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016695 Walker A motif; other site 502025016696 ATP binding site [chemical binding]; other site 502025016697 Walker B motif; other site 502025016698 arginine finger; other site 502025016699 Helix-turn-helix domains; Region: HTH; cl00088 502025016700 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 502025016701 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 502025016702 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025016703 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 502025016704 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 502025016705 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 502025016706 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025016707 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 502025016708 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025016709 nudix motif; other site 502025016710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025016711 active site 502025016712 Int/Topo IB signature motif; other site 502025016713 DNA binding site [nucleotide binding] 502025016714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025016715 non-specific DNA binding site [nucleotide binding]; other site 502025016716 salt bridge; other site 502025016717 sequence-specific DNA binding site [nucleotide binding]; other site 502025016718 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025016719 phosphopeptide binding site; other site 502025016720 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016721 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016722 active site 502025016723 ATP binding site [chemical binding]; other site 502025016724 substrate binding site [chemical binding]; other site 502025016725 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016726 substrate binding site [chemical binding]; other site 502025016727 activation loop (A-loop); other site 502025016728 activation loop (A-loop); other site 502025016729 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025016730 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 502025016731 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 502025016732 NAD binding site [chemical binding]; other site 502025016733 substrate binding site [chemical binding]; other site 502025016734 homodimer interface [polypeptide binding]; other site 502025016735 active site 502025016736 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016737 metal ion-dependent adhesion site (MIDAS); other site 502025016738 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025016739 active site 502025016740 metal binding site [ion binding]; metal-binding site 502025016741 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025016742 Protein kinase domain; Region: Pkinase; pfam00069 502025016743 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016744 active site 502025016745 ATP binding site [chemical binding]; other site 502025016746 substrate binding site [chemical binding]; other site 502025016747 activation loop (A-loop); other site 502025016748 PAS domain S-box; Region: sensory_box; TIGR00229 502025016749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016750 putative active site [active] 502025016751 heme pocket [chemical binding]; other site 502025016752 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025016753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016754 dimer interface [polypeptide binding]; other site 502025016755 phosphorylation site [posttranslational modification] 502025016756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016757 ATP binding site [chemical binding]; other site 502025016758 Mg2+ binding site [ion binding]; other site 502025016759 G-X-G motif; other site 502025016760 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016762 active site 502025016763 phosphorylation site [posttranslational modification] 502025016764 intermolecular recognition site; other site 502025016765 dimerization interface [polypeptide binding]; other site 502025016766 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025016767 DNA primase; Validated; Region: dnaG; PRK05667 502025016768 CHC2 zinc finger; Region: zf-CHC2; cl15369 502025016769 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025016770 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 502025016771 active site 502025016772 metal binding site [ion binding]; metal-binding site 502025016773 interdomain interaction site; other site 502025016774 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 502025016775 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 502025016776 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 502025016777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025016778 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025016779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025016780 DNA binding residues [nucleotide binding] 502025016781 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 502025016782 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025016783 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 502025016784 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 502025016785 MatE; Region: MatE; cl10513 502025016786 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 502025016787 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 502025016788 DNA binding residues [nucleotide binding] 502025016789 B12 binding domain; Region: B12-binding_2; cl03653 502025016790 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 502025016791 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 502025016792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025016793 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025016794 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 502025016795 dimer interface [polypeptide binding]; other site 502025016796 active site 502025016797 CoA binding pocket [chemical binding]; other site 502025016798 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 502025016799 RNA/DNA hybrid binding site [nucleotide binding]; other site 502025016800 active site 502025016801 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 502025016802 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 502025016803 Interdomain contacts; other site 502025016804 Cytokine receptor motif; other site 502025016805 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 502025016806 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 502025016807 Protein of unknown function (DUF421); Region: DUF421; cl00990 502025016808 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025016809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016810 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025016811 NAD(P) binding site [chemical binding]; other site 502025016812 active site 502025016813 hypothetical protein; Provisional; Region: PRK01254 502025016814 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025016815 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025016816 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 502025016817 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025016818 amidase catalytic site [active] 502025016819 Zn binding residues [ion binding]; other site 502025016820 substrate binding site [chemical binding]; other site 502025016821 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 502025016822 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025016823 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025016824 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025016825 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025016826 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025016827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016828 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016829 active site 502025016830 ATP binding site [chemical binding]; other site 502025016831 substrate binding site [chemical binding]; other site 502025016832 activation loop (A-loop); other site 502025016833 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 502025016834 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 502025016835 active site 502025016836 Zn binding site [ion binding]; other site 502025016837 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025016838 putative catalytic site [active] 502025016839 putative metal binding site [ion binding]; other site 502025016840 putative phosphate binding site [ion binding]; other site 502025016841 Protein kinase domain; Region: Pkinase; pfam00069 502025016842 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016843 active site 502025016844 ATP binding site [chemical binding]; other site 502025016845 substrate binding site [chemical binding]; other site 502025016846 activation loop (A-loop); other site 502025016847 Predicted ATPase [General function prediction only]; Region: COG3899 502025016848 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016850 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016851 active site 502025016852 ATP binding site [chemical binding]; other site 502025016853 substrate binding site [chemical binding]; other site 502025016854 activation loop (A-loop); other site 502025016855 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016856 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 502025016857 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 502025016858 Di-iron ligands [ion binding]; other site 502025016859 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 502025016860 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 502025016861 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025016862 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 502025016863 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 502025016864 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025016865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016866 active site 502025016867 phosphorylation site [posttranslational modification] 502025016868 intermolecular recognition site; other site 502025016869 dimerization interface [polypeptide binding]; other site 502025016870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016871 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 502025016872 Domain of unknown function (DUF955); Region: DUF955; cl01076 502025016873 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 502025016874 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 502025016875 malate synthase A; Region: malate_syn_A; TIGR01344 502025016876 active site 502025016877 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 502025016878 tetramer interface [polypeptide binding]; other site 502025016879 active site 502025016880 Mg2+/Mn2+ binding site [ion binding]; other site 502025016881 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 502025016882 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 502025016883 putative dimer interface [polypeptide binding]; other site 502025016884 5-oxoprolinase; Region: PLN02666 502025016885 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 502025016886 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 502025016887 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025016888 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025016889 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 502025016890 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 502025016891 OPT oligopeptide transporter protein; Region: OPT; cl14607 502025016892 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025016893 PilZ domain; Region: PilZ; cl01260 502025016894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016895 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016896 active site 502025016897 phosphorylation site [posttranslational modification] 502025016898 intermolecular recognition site; other site 502025016899 dimerization interface [polypeptide binding]; other site 502025016900 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 502025016901 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 502025016902 CysD dimerization site [polypeptide binding]; other site 502025016903 G1 box; other site 502025016904 putative GEF interaction site [polypeptide binding]; other site 502025016905 GTP/Mg2+ binding site [chemical binding]; other site 502025016906 Switch I region; other site 502025016907 G2 box; other site 502025016908 G3 box; other site 502025016909 Switch II region; other site 502025016910 G4 box; other site 502025016911 G5 box; other site 502025016912 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 502025016913 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 502025016914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016915 active site 502025016916 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 502025016917 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 502025016918 Active Sites [active] 502025016919 putative ATPase subunit of terminase; Provisional; Region: PHA03333 502025016920 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025016921 ligand binding site [chemical binding]; other site 502025016922 flexible hinge region; other site 502025016923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016925 binding surface 502025016926 TPR motif; other site 502025016927 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016928 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016929 active site 502025016930 ATP binding site [chemical binding]; other site 502025016931 substrate binding site [chemical binding]; other site 502025016932 activation loop (A-loop); other site 502025016933 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 502025016934 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 502025016935 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 502025016936 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 502025016937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025016938 ABC transporter signature motif; other site 502025016939 Walker B; other site 502025016940 D-loop; other site 502025016941 H-loop/switch region; other site 502025016942 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 502025016943 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 502025016944 active site 502025016945 catalytic triad [active] 502025016946 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 502025016947 MPT binding site; other site 502025016948 trimer interface [polypeptide binding]; other site 502025016949 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 502025016950 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 502025016951 HIGH motif; other site 502025016952 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 502025016953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025016954 active site 502025016955 KMSKS motif; other site 502025016956 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 502025016957 tRNA binding surface [nucleotide binding]; other site 502025016958 adenylate kinase; Reviewed; Region: adk; PRK00279 502025016959 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 502025016960 AMP-binding site [chemical binding]; other site 502025016961 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 502025016962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025016963 non-specific DNA binding site [nucleotide binding]; other site 502025016964 salt bridge; other site 502025016965 sequence-specific DNA binding site [nucleotide binding]; other site 502025016966 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025016967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025016968 ligand binding site [chemical binding]; other site 502025016969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025016970 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 502025016971 substrate binding site [chemical binding]; other site 502025016972 oxyanion hole (OAH) forming residues; other site 502025016973 trimer interface [polypeptide binding]; other site 502025016974 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 502025016975 NodB motif; other site 502025016976 putative active site [active] 502025016977 putative catalytic site [active] 502025016978 putative Zn binding site [ion binding]; other site 502025016979 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 502025016980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016982 active site 502025016983 ATP binding site [chemical binding]; other site 502025016984 substrate binding site [chemical binding]; other site 502025016985 activation loop (A-loop); other site 502025016986 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025016987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025016988 enoyl-CoA hydratase; Validated; Region: PRK08139 502025016989 substrate binding site [chemical binding]; other site 502025016990 oxyanion hole (OAH) forming residues; other site 502025016991 trimer interface [polypeptide binding]; other site 502025016992 SCP-2 sterol transfer family; Region: SCP2; cl01225 502025016993 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 502025016994 CoA-transferase family III; Region: CoA_transf_3; pfam02515 502025016995 aspartate kinase III; Validated; Region: PRK09084 502025016996 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025016997 nucleotide binding site [chemical binding]; other site 502025016998 substrate binding site [chemical binding]; other site 502025016999 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 502025017000 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 502025017001 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017003 active site 502025017004 ATP binding site [chemical binding]; other site 502025017005 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017006 substrate binding site [chemical binding]; other site 502025017007 activation loop (A-loop); other site 502025017008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017009 Integrase core domain; Region: rve; cl01316 502025017010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017011 Walker A motif; other site 502025017012 ATP binding site [chemical binding]; other site 502025017013 Walker B motif; other site 502025017014 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025017015 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025017016 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017017 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025017018 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017019 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025017020 ligand binding site [chemical binding]; other site 502025017021 PSP1 C-terminal conserved region; Region: PSP1; cl00770 502025017022 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 502025017023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017024 Walker A motif; other site 502025017025 ATP binding site [chemical binding]; other site 502025017026 Walker B motif; other site 502025017027 arginine finger; other site 502025017028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017029 binding surface 502025017030 TPR motif; other site 502025017031 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025017032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017033 TPR motif; other site 502025017034 binding surface 502025017035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025017036 binding surface 502025017037 TPR motif; other site 502025017038 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 502025017039 MatE; Region: MatE; cl10513 502025017040 Helix-turn-helix domains; Region: HTH; cl00088 502025017041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025017042 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 502025017043 Walker A/P-loop; other site 502025017044 ATP binding site [chemical binding]; other site 502025017045 Q-loop/lid; other site 502025017046 ABC transporter signature motif; other site 502025017047 Walker B; other site 502025017048 D-loop; other site 502025017049 H-loop/switch region; other site 502025017050 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025017051 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025017052 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025017053 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 502025017054 Zn binding site [ion binding]; other site 502025017055 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 502025017056 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 502025017057 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025017058 active site 502025017059 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025017060 single-stranded binding protein UL29; Provisional; Region: PHA03362 502025017061 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 502025017062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025017063 binding surface 502025017064 TPR motif; other site 502025017065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017066 binding surface 502025017067 TPR motif; other site 502025017068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017069 binding surface 502025017070 TPR motif; other site 502025017071 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025017072 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025017073 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025017074 SLBB domain; Region: SLBB; pfam10531 502025017075 O-Antigen ligase; Region: Wzy_C; cl04850 502025017076 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025017077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017078 S-adenosylmethionine binding site [chemical binding]; other site 502025017079 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 502025017080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017081 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 502025017082 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 502025017083 dimer interface [polypeptide binding]; other site 502025017084 active site 502025017085 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025017086 catalytic residues [active] 502025017087 substrate binding site [chemical binding]; other site 502025017088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025017089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025017090 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025017091 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025017092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025017093 FeS/SAM binding site; other site 502025017094 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 502025017095 FG-GAP repeat; Region: FG-GAP; cl15299 502025017096 FG-GAP repeat; Region: FG-GAP; cl15299 502025017097 FG-GAP repeat; Region: FG-GAP; cl15299 502025017098 mercuric reductase; Validated; Region: PRK06370 502025017099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025017100 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025017101 hypothetical protein; Provisional; Region: PRK11770 502025017102 Domain of unknown function (DUF307); Region: DUF307; pfam03733 502025017103 Domain of unknown function (DUF307); Region: DUF307; pfam03733 502025017104 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 502025017105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025017106 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025017107 molybdopterin cofactor binding site; other site 502025017108 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 502025017109 putative molybdopterin cofactor binding site; other site 502025017110 Cation efflux family; Region: Cation_efflux; cl00316 502025017111 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025017112 metal binding triad [ion binding]; metal-binding site 502025017113 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 502025017114 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 502025017115 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025017116 NADP binding site [chemical binding]; other site 502025017117 substrate binding site [chemical binding]; other site 502025017118 active site 502025017119 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 502025017120 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 502025017121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025017122 FeS/SAM binding site; other site 502025017123 HemN C-terminal domain; Region: HemN_C; pfam06969 502025017124 Phosphopantetheine attachment site; Region: PP-binding; cl09936 502025017125 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 502025017126 AMP-binding enzyme; Region: AMP-binding; cl15778 502025017127 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 502025017128 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 502025017129 K-Cl cotransporter; Region: 2a30; TIGR00930 502025017130 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025017131 FAD binding domain; Region: FAD_binding_4; pfam01565 502025017132 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 502025017133 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 502025017134 AMP-binding enzyme; Region: AMP-binding; cl15778 502025017135 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017136 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 502025017137 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 502025017138 homodimer interface [polypeptide binding]; other site 502025017139 substrate-cofactor binding pocket; other site 502025017140 catalytic residue [active] 502025017141 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 502025017142 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 502025017143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025017144 active site 502025017145 catalytic tetrad [active] 502025017146 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 502025017147 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 502025017148 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 502025017149 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 502025017150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017151 Walker A motif; other site 502025017152 ATP binding site [chemical binding]; other site 502025017153 Walker B motif; other site 502025017154 arginine finger; other site 502025017155 Helix-turn-helix domains; Region: HTH; cl00088 502025017156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 502025017157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025017158 dimerization interface [polypeptide binding]; other site 502025017159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017160 dimer interface [polypeptide binding]; other site 502025017161 phosphorylation site [posttranslational modification] 502025017162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017163 ATP binding site [chemical binding]; other site 502025017164 Mg2+ binding site [ion binding]; other site 502025017165 G-X-G motif; other site 502025017166 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017168 active site 502025017169 phosphorylation site [posttranslational modification] 502025017170 intermolecular recognition site; other site 502025017171 dimerization interface [polypeptide binding]; other site 502025017172 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017174 active site 502025017175 phosphorylation site [posttranslational modification] 502025017176 intermolecular recognition site; other site 502025017177 dimerization interface [polypeptide binding]; other site 502025017178 two component system sensor kinase SsrA; Provisional; Region: PRK15347 502025017179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017180 dimer interface [polypeptide binding]; other site 502025017181 phosphorylation site [posttranslational modification] 502025017182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017183 ATP binding site [chemical binding]; other site 502025017184 Mg2+ binding site [ion binding]; other site 502025017185 G-X-G motif; other site 502025017186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025017187 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 502025017188 dimer interface [polypeptide binding]; other site 502025017189 active site 502025017190 metal binding site [ion binding]; metal-binding site 502025017191 glutathione binding site [chemical binding]; other site 502025017192 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025017193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025017194 ATP binding site [chemical binding]; other site 502025017195 putative Mg++ binding site [ion binding]; other site 502025017196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025017197 nucleotide binding region [chemical binding]; other site 502025017198 ATP-binding site [chemical binding]; other site 502025017199 DEAD/H associated; Region: DEAD_assoc; pfam08494 502025017200 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 502025017201 RNA polymerase III subunit RPC82 helix-turn-helix domain; Region: HTH_9; pfam08221 502025017202 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 502025017203 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017204 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017205 active site 502025017206 ATP binding site [chemical binding]; other site 502025017207 substrate binding site [chemical binding]; other site 502025017208 activation loop (A-loop); other site 502025017209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017210 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 502025017211 glycogen binding site [chemical binding]; other site 502025017212 Cupin domain; Region: Cupin_2; cl09118 502025017213 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 502025017214 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 502025017215 dimer interface [polypeptide binding]; other site 502025017216 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 502025017217 active site 502025017218 Fe binding site [ion binding]; other site 502025017219 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025017220 maleylacetoacetate isomerase; Region: maiA; TIGR01262 502025017221 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 502025017222 dimer interface [polypeptide binding]; other site 502025017223 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 502025017224 N-terminal domain interface [polypeptide binding]; other site 502025017225 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 502025017226 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 502025017227 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 502025017228 Helix-turn-helix domains; Region: HTH; cl00088 502025017229 AsnC family; Region: AsnC_trans_reg; pfam01037 502025017230 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 502025017231 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 502025017232 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 502025017233 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017234 active site 502025017235 ATP binding site [chemical binding]; other site 502025017236 substrate binding site [chemical binding]; other site 502025017237 activation loop (A-loop); other site 502025017238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017239 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025017240 GTP cyclohydrolase I; Provisional; Region: PLN03044 502025017241 active site 502025017242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017244 active site 502025017245 ATP binding site [chemical binding]; other site 502025017246 substrate binding site [chemical binding]; other site 502025017247 activation loop (A-loop); other site 502025017248 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 502025017249 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 502025017250 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 502025017251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025017252 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 502025017253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025017254 active site 502025017255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017256 S-adenosylmethionine binding site [chemical binding]; other site 502025017257 Acylphosphatase; Region: Acylphosphatase; cl00551 502025017258 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025017259 active site 502025017260 metal binding site [ion binding]; metal-binding site 502025017261 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 502025017262 peptide chain release factor 1; Validated; Region: prfA; PRK00591 502025017263 RF-1 domain; Region: RF-1; cl02875 502025017264 RF-1 domain; Region: RF-1; cl02875 502025017265 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025017266 catalytic residues [active] 502025017267 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025017268 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025017269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025017270 Helix-turn-helix domains; Region: HTH; cl00088 502025017271 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 502025017272 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 502025017273 Ligand binding site [chemical binding]; other site 502025017274 Electron transfer flavoprotein domain; Region: ETF; pfam01012 502025017275 Electron transfer flavoprotein domain; Region: ETF; pfam01012 502025017276 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 502025017277 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 502025017278 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 502025017279 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025017280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017281 Walker A motif; other site 502025017282 ATP binding site [chemical binding]; other site 502025017283 Walker B motif; other site 502025017284 arginine finger; other site 502025017285 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025017286 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025017287 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 502025017288 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 502025017289 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 502025017290 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 502025017291 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 502025017292 ring oligomerisation interface [polypeptide binding]; other site 502025017293 ATP/Mg binding site [chemical binding]; other site 502025017294 stacking interactions; other site 502025017295 hinge regions; other site 502025017296 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025017297 oligomerisation interface [polypeptide binding]; other site 502025017298 mobile loop; other site 502025017299 roof hairpin; other site 502025017300 PAS fold; Region: PAS_3; pfam08447 502025017301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 502025017302 PAS fold; Region: PAS_4; pfam08448 502025017303 PAS domain S-box; Region: sensory_box; TIGR00229 502025017304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025017305 putative active site [active] 502025017306 heme pocket [chemical binding]; other site 502025017307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025017308 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025017309 putative active site [active] 502025017310 heme pocket [chemical binding]; other site 502025017311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017312 dimer interface [polypeptide binding]; other site 502025017313 phosphorylation site [posttranslational modification] 502025017314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017315 ATP binding site [chemical binding]; other site 502025017316 Mg2+ binding site [ion binding]; other site 502025017317 G-X-G motif; other site 502025017318 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017320 active site 502025017321 phosphorylation site [posttranslational modification] 502025017322 intermolecular recognition site; other site 502025017323 dimerization interface [polypeptide binding]; other site 502025017324 selenophosphate synthetase; Provisional; Region: PRK00943 502025017325 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 502025017326 dimerization interface [polypeptide binding]; other site 502025017327 putative ATP binding site [chemical binding]; other site 502025017328 ferredoxin-NADP+ reductase; Region: PLN02852 502025017329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017330 Chorismate mutase type II; Region: CM_2; cl00693 502025017331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017332 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 502025017333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017334 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 502025017335 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 502025017336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025017337 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 502025017338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025017339 dimer interface [polypeptide binding]; other site 502025017340 conserved gate region; other site 502025017341 putative PBP binding loops; other site 502025017342 ABC-ATPase subunit interface; other site 502025017343 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 502025017344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017345 Walker A/P-loop; other site 502025017346 ATP binding site [chemical binding]; other site 502025017347 Q-loop/lid; other site 502025017348 ABC transporter signature motif; other site 502025017349 Walker B; other site 502025017350 D-loop; other site 502025017351 H-loop/switch region; other site 502025017352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025017353 non-specific DNA binding site [nucleotide binding]; other site 502025017354 salt bridge; other site 502025017355 sequence-specific DNA binding site [nucleotide binding]; other site 502025017356 hypothetical protein; Provisional; Region: PRK08609 502025017357 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 502025017358 active site 502025017359 primer binding site [nucleotide binding]; other site 502025017360 NTP binding site [chemical binding]; other site 502025017361 metal binding triad [ion binding]; metal-binding site 502025017362 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 502025017363 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 502025017364 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025017365 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025017366 protein binding site [polypeptide binding]; other site 502025017367 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 502025017368 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 502025017369 substrate binding site [chemical binding]; other site 502025017370 glutamase interaction surface [polypeptide binding]; other site 502025017371 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 502025017372 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 502025017373 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 502025017374 metal binding site [ion binding]; metal-binding site 502025017375 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 502025017376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017377 DEAD_2; Region: DEAD_2; pfam06733 502025017378 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017379 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 502025017380 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 502025017381 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 502025017382 G1 box; other site 502025017383 putative GEF interaction site [polypeptide binding]; other site 502025017384 GTP/Mg2+ binding site [chemical binding]; other site 502025017385 Switch I region; other site 502025017386 G2 box; other site 502025017387 G3 box; other site 502025017388 Switch II region; other site 502025017389 G4 box; other site 502025017390 G5 box; other site 502025017391 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 502025017392 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 502025017393 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 502025017394 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 502025017395 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 502025017396 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 502025017397 substrate-cofactor binding pocket; other site 502025017398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017399 catalytic residue [active] 502025017400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025017401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017402 NAD(P) binding site [chemical binding]; other site 502025017403 active site 502025017404 Lamin Tail Domain; Region: LTD; pfam00932 502025017405 Bacterial Ig-like domain; Region: Big_5; cl01012 502025017406 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 502025017407 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 502025017408 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 502025017409 putative active site [active] 502025017410 catalytic site [active] 502025017411 putative metal binding site [ion binding]; other site 502025017412 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 502025017413 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 502025017414 putative ligand binding site [chemical binding]; other site 502025017415 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 502025017416 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 502025017417 Walker A/P-loop; other site 502025017418 ATP binding site [chemical binding]; other site 502025017419 Q-loop/lid; other site 502025017420 ABC transporter signature motif; other site 502025017421 Walker B; other site 502025017422 D-loop; other site 502025017423 H-loop/switch region; other site 502025017424 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 502025017425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 502025017426 TM-ABC transporter signature motif; other site 502025017427 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025017428 catalytic triad [active] 502025017429 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 502025017430 NlpC/P60 family; Region: NLPC_P60; cl11438 502025017431 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 502025017432 nucleotide binding site [chemical binding]; other site 502025017433 Tir chaperone protein (CesT) family; Region: CesT; cl08444 502025017434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025017435 Helix-turn-helix domains; Region: HTH; cl00088 502025017436 Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389 502025017437 OsmC-like protein; Region: OsmC; cl00767 502025017438 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 502025017439 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025017440 nudix motif; other site 502025017441 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 502025017442 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025017443 inhibitor-cofactor binding pocket; inhibition site 502025017444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017445 catalytic residue [active] 502025017446 CsbD-like; Region: CsbD; cl15799 502025017447 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025017448 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025017449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025017450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 502025017451 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 502025017452 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025017453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025017454 protein binding site [polypeptide binding]; other site 502025017455 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025017456 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025017457 phosphoglucomutase; Validated; Region: PRK07564 502025017458 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 502025017459 active site 502025017460 substrate binding site [chemical binding]; other site 502025017461 metal binding site [ion binding]; metal-binding site 502025017462 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 502025017463 catalytic triad [active] 502025017464 dimer interface [polypeptide binding]; other site 502025017465 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 502025017466 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025017467 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 502025017468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025017469 active site 502025017470 HIGH motif; other site 502025017471 nucleotide binding site [chemical binding]; other site 502025017472 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 502025017473 KMSKS motif; other site 502025017474 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 502025017475 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017476 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017477 active site 502025017478 ATP binding site [chemical binding]; other site 502025017479 substrate binding site [chemical binding]; other site 502025017480 activation loop (A-loop); other site 502025017481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017482 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017484 binding surface 502025017485 TPR motif; other site 502025017486 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025017487 Ligand Binding Site [chemical binding]; other site 502025017488 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025017489 Ligand Binding Site [chemical binding]; other site 502025017490 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025017491 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 502025017492 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 502025017493 Substrate binding site; other site 502025017494 Mg++ binding site; other site 502025017495 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 502025017496 active site 502025017497 substrate binding site [chemical binding]; other site 502025017498 CoA binding site [chemical binding]; other site 502025017499 HupE / UreJ protein; Region: HupE_UreJ; cl01011 502025017500 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017501 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017502 active site 502025017503 ATP binding site [chemical binding]; other site 502025017504 substrate binding site [chemical binding]; other site 502025017505 activation loop (A-loop); other site 502025017506 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025017507 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025017508 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017509 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025017510 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017511 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017512 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017513 active site 502025017514 ATP binding site [chemical binding]; other site 502025017515 substrate binding site [chemical binding]; other site 502025017516 activation loop (A-loop); other site 502025017517 allantoate amidohydrolase; Reviewed; Region: PRK09290 502025017518 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 502025017519 active site 502025017520 metal binding site [ion binding]; metal-binding site 502025017521 dimer interface [polypeptide binding]; other site 502025017522 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 502025017523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 502025017524 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025017525 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 502025017526 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 502025017527 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025017528 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 502025017529 aconitate hydratase; Validated; Region: PRK09277 502025017530 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 502025017531 substrate binding site [chemical binding]; other site 502025017532 ligand binding site [chemical binding]; other site 502025017533 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 502025017534 substrate binding site [chemical binding]; other site 502025017535 Ion transport protein; Region: Ion_trans; pfam00520 502025017536 Ion channel; Region: Ion_trans_2; cl11596 502025017537 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025017538 ribonuclease D; Region: rnd; TIGR01388 502025017539 putative active site [active] 502025017540 putative substrate binding site [chemical binding]; other site 502025017541 catalytic site [active] 502025017542 HRDC domain; Region: HRDC; cl02578 502025017543 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025017544 P loop; other site 502025017545 Nucleotide binding site [chemical binding]; other site 502025017546 DTAP/Switch II; other site 502025017547 Switch I; other site 502025017548 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025017549 pyruvate carboxylase subunit B; Validated; Region: PRK09282 502025017550 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025017551 carboxyltransferase (CT) interaction site; other site 502025017552 biotinylation site [posttranslational modification]; other site 502025017553 CotH protein; Region: CotH; pfam08757 502025017554 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025017555 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025017556 protein binding site [polypeptide binding]; other site 502025017557 Cytochrome c; Region: Cytochrom_C; cl11414 502025017558 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 502025017559 BON domain; Region: BON; cl02771 502025017560 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 502025017561 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 502025017562 BON domain; Region: BON; cl02771 502025017563 BON domain; Region: BON; cl02771 502025017564 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025017565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025017566 ATP binding site [chemical binding]; other site 502025017567 putative Mg++ binding site [ion binding]; other site 502025017568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025017569 nucleotide binding region [chemical binding]; other site 502025017570 ATP-binding site [chemical binding]; other site 502025017571 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 502025017572 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 502025017573 active site 502025017574 Zn binding site [ion binding]; other site 502025017575 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017577 active site 502025017578 phosphorylation site [posttranslational modification] 502025017579 intermolecular recognition site; other site 502025017580 dimerization interface [polypeptide binding]; other site 502025017581 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 502025017582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025017583 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017584 activation loop (A-loop); other site 502025017585 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017587 Predicted ATPase [General function prediction only]; Region: COG3899 502025017588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025017589 GAF domain; Region: GAF; cl15785 502025017590 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025017591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017592 ATP binding site [chemical binding]; other site 502025017593 Mg2+ binding site [ion binding]; other site 502025017594 G-X-G motif; other site 502025017595 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 502025017596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017597 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025017598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025017599 fatty oxidation complex, alpha subunit FadB; Region: FadB; TIGR02437 502025017600 substrate binding site [chemical binding]; other site 502025017601 oxyanion hole (OAH) forming residues; other site 502025017602 trimer interface [polypeptide binding]; other site 502025017603 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 502025017604 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025017605 dimer interface [polypeptide binding]; other site 502025017606 active site 502025017607 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025017608 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025017609 calcium binding site 2 [ion binding]; other site 502025017610 active site 502025017611 catalytic triad [active] 502025017612 calcium binding site 1 [ion binding]; other site 502025017613 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 502025017614 PKC phosphorylation site [posttranslational modification]; other site 502025017615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025017616 ligand binding site [chemical binding]; other site 502025017617 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 502025017618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017619 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 502025017620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017621 active site 502025017622 phosphorylation site [posttranslational modification] 502025017623 intermolecular recognition site; other site 502025017624 dimerization interface [polypeptide binding]; other site 502025017625 PilZ domain; Region: PilZ; cl01260 502025017626 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025017627 anti sigma factor interaction site; other site 502025017628 regulatory phosphorylation site [posttranslational modification]; other site 502025017629 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025017630 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 502025017631 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025017632 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 502025017633 homodimer interface [polypeptide binding]; other site 502025017634 substrate-cofactor binding pocket; other site 502025017635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017636 catalytic residue [active] 502025017637 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025017638 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025017639 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017640 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017641 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017642 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017643 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025017644 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017645 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025017646 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025017647 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025017648 phosphopeptide binding site; other site 502025017649 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 502025017650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017651 Walker A motif; other site 502025017652 ATP binding site [chemical binding]; other site 502025017653 Walker B motif; other site 502025017654 arginine finger; other site 502025017655 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025017656 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025017657 calcium binding site 2 [ion binding]; other site 502025017658 active site 502025017659 catalytic triad [active] 502025017660 calcium binding site 1 [ion binding]; other site 502025017661 Somatomedin B domain; Region: Somatomedin_B; cl02508 502025017662 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 502025017663 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 502025017664 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 502025017665 active site 502025017666 dimer interface [polypeptide binding]; other site 502025017667 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 502025017668 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 502025017669 active site 502025017670 FMN binding site [chemical binding]; other site 502025017671 substrate binding site [chemical binding]; other site 502025017672 3Fe-4S cluster binding site [ion binding]; other site 502025017673 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 502025017674 domain interface; other site 502025017675 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025017676 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025017677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017678 Walker A motif; other site 502025017679 ATP binding site [chemical binding]; other site 502025017680 Walker B motif; other site 502025017681 arginine finger; other site 502025017682 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 502025017683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017684 S-adenosylmethionine binding site [chemical binding]; other site 502025017685 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 502025017686 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 502025017687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025017688 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 502025017689 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 502025017690 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025017691 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 502025017692 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025017693 N-terminal plug; other site 502025017694 ligand-binding site [chemical binding]; other site 502025017695 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 502025017696 kelch-like protein; Provisional; Region: PHA03098 502025017697 kelch-like protein; Provisional; Region: PHA03098 502025017698 Galactose oxidase, central domain; Region: Kelch_3; cl02701 502025017699 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 502025017700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017701 ATP binding site [chemical binding]; other site 502025017702 Mg2+ binding site [ion binding]; other site 502025017703 G-X-G motif; other site 502025017704 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017706 active site 502025017707 phosphorylation site [posttranslational modification] 502025017708 intermolecular recognition site; other site 502025017709 dimerization interface [polypeptide binding]; other site 502025017710 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025017711 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025017712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017713 Walker A motif; other site 502025017714 ATP binding site [chemical binding]; other site 502025017715 Walker B motif; other site 502025017716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025017717 Walker A motif; other site 502025017718 ATP binding site [chemical binding]; other site 502025017719 Walker B motif; other site 502025017720 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 502025017721 MgtE intracellular N domain; Region: MgtE_N; cl15244 502025017722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 502025017723 Divalent cation transporter; Region: MgtE; cl00786 502025017724 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 502025017725 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025017726 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 502025017727 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 502025017728 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 502025017729 putative active site [active] 502025017730 putative metal binding site [ion binding]; other site 502025017731 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 502025017732 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025017733 TM-ABC transporter signature motif; other site 502025017734 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025017735 TM-ABC transporter signature motif; other site 502025017736 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 502025017737 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 502025017738 Walker A/P-loop; other site 502025017739 ATP binding site [chemical binding]; other site 502025017740 Q-loop/lid; other site 502025017741 ABC transporter signature motif; other site 502025017742 Walker B; other site 502025017743 D-loop; other site 502025017744 H-loop/switch region; other site 502025017745 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 502025017746 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 502025017747 ligand binding site [chemical binding]; other site 502025017748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025017749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025017750 DNA binding site [nucleotide binding] 502025017751 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 502025017752 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025017753 tetrameric interface [polypeptide binding]; other site 502025017754 NAD binding site [chemical binding]; other site 502025017755 catalytic residues [active] 502025017756 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 502025017757 active site 502025017758 substrate specificity residue; other site 502025017759 DNA binding site [nucleotide binding] 502025017760 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 502025017761 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 502025017762 putative metal binding site [ion binding]; other site 502025017763 tocopherol O-methyltransferase; Region: PLN02244 502025017764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017765 S-adenosylmethionine binding site [chemical binding]; other site 502025017766 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 502025017767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017768 S-adenosylmethionine binding site [chemical binding]; other site 502025017769 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 502025017770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025017771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025017772 catalytic residue [active] 502025017773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025017774 dimer interface [polypeptide binding]; other site 502025017775 putative CheW interface [polypeptide binding]; other site 502025017776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017777 NAD(P) binding site [chemical binding]; other site 502025017778 active site 502025017779 FG-GAP repeat; Region: FG-GAP; cl15299 502025017780 FG-GAP repeat; Region: FG-GAP; cl15299 502025017781 FG-GAP repeat; Region: FG-GAP; cl15299 502025017782 FG-GAP repeat; Region: FG-GAP; cl15299 502025017783 FG-GAP repeat; Region: FG-GAP; cl15299 502025017784 FG-GAP repeat; Region: FG-GAP; cl15299 502025017785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017786 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017787 active site 502025017788 ATP binding site [chemical binding]; other site 502025017789 substrate binding site [chemical binding]; other site 502025017790 activation loop (A-loop); other site 502025017791 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025017792 TPR repeat; Region: TPR_11; pfam13414 502025017793 agmatine deiminase; Region: agmatine_aguA; TIGR03380 502025017794 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 502025017795 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 502025017796 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 502025017797 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017798 active site 502025017799 substrate binding site [chemical binding]; other site 502025017800 ATP binding site [chemical binding]; other site 502025017801 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017802 substrate binding site [chemical binding]; other site 502025017803 activation loop (A-loop); other site 502025017804 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017805 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025017806 Amidohydrolase; Region: Amidohydro_4; pfam13147 502025017807 active site 502025017808 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 502025017809 active site 502025017810 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025017811 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 502025017812 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 502025017813 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 502025017814 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 502025017815 GatB domain; Region: GatB_Yqey; cl11497 502025017816 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 502025017817 Amidase; Region: Amidase; cl11426 502025017818 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 502025017819 Transcriptional regulators [Transcription]; Region: FadR; COG2186 502025017820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 502025017821 DNA-binding site [nucleotide binding]; DNA binding site 502025017822 FCD domain; Region: FCD; cl11656 502025017823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025017824 HSP70 interaction site [polypeptide binding]; other site 502025017825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025017826 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025017827 active site 502025017828 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 502025017829 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 502025017830 active site 502025017831 Substrate binding site; other site 502025017832 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 502025017833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025017834 RNA binding surface [nucleotide binding]; other site 502025017835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025017836 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025017837 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 502025017838 RNA/DNA binding site [nucleotide binding]; other site 502025017839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017840 active site 502025017841 phosphorylation site [posttranslational modification] 502025017842 intermolecular recognition site; other site 502025017843 dimerization interface [polypeptide binding]; other site 502025017844 PilZ domain; Region: PilZ; cl01260 502025017845 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017847 active site 502025017848 phosphorylation site [posttranslational modification] 502025017849 intermolecular recognition site; other site 502025017850 dimerization interface [polypeptide binding]; other site 502025017851 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017853 active site 502025017854 phosphorylation site [posttranslational modification] 502025017855 intermolecular recognition site; other site 502025017856 dimerization interface [polypeptide binding]; other site 502025017857 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 502025017858 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017860 active site 502025017861 phosphorylation site [posttranslational modification] 502025017862 intermolecular recognition site; other site 502025017863 dimerization interface [polypeptide binding]; other site 502025017864 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025017865 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 502025017866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025017867 dimer interface [polypeptide binding]; other site 502025017868 putative CheW interface [polypeptide binding]; other site 502025017869 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025017870 putative binding surface; other site 502025017871 active site 502025017872 sensory histidine kinase CreC; Provisional; Region: PRK11100 502025017873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017874 ATP binding site [chemical binding]; other site 502025017875 Mg2+ binding site [ion binding]; other site 502025017876 G-X-G motif; other site 502025017877 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025017878 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025017879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017880 active site 502025017881 phosphorylation site [posttranslational modification] 502025017882 intermolecular recognition site; other site 502025017883 dimerization interface [polypeptide binding]; other site 502025017884 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 502025017885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017886 active site 502025017887 phosphorylation site [posttranslational modification] 502025017888 intermolecular recognition site; other site 502025017889 dimerization interface [polypeptide binding]; other site 502025017890 CheB methylesterase; Region: CheB_methylest; pfam01339 502025017891 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025017892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025017893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017894 binding surface 502025017895 TPR motif; other site 502025017896 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 502025017897 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017898 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017899 active site 502025017900 ATP binding site [chemical binding]; other site 502025017901 substrate binding site [chemical binding]; other site 502025017902 activation loop (A-loop); other site 502025017903 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 502025017904 BNR repeat-like domain; Region: BNR_2; pfam13088 502025017905 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 502025017906 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 502025017907 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 502025017908 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 502025017909 tRNA; other site 502025017910 putative tRNA binding site [nucleotide binding]; other site 502025017911 putative NADP binding site [chemical binding]; other site 502025017912 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 502025017913 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 502025017914 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 502025017915 domain interfaces; other site 502025017916 active site 502025017917 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025017918 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 502025017919 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025017920 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 502025017921 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025017922 ligand binding site [chemical binding]; other site 502025017923 flexible hinge region; other site 502025017924 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 502025017925 peptidase domain interface [polypeptide binding]; other site 502025017926 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 502025017927 active site 502025017928 catalytic triad [active] 502025017929 calcium binding site [ion binding]; other site 502025017930 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 502025017931 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 502025017932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017933 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 502025017934 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 502025017935 generic binding surface II; other site 502025017936 generic binding surface I; other site 502025017937 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 502025017938 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 502025017939 active site 502025017940 HIGH motif; other site 502025017941 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 502025017942 KMSKS motif; other site 502025017943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025017944 tRNA binding surface [nucleotide binding]; other site 502025017945 anticodon binding site; other site 502025017946 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 502025017947 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 502025017948 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 502025017949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 502025017950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025017951 Protein of unknown function (DUF971); Region: DUF971; cl01414 502025017952 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 502025017953 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 502025017954 putative molybdopterin cofactor binding site [chemical binding]; other site 502025017955 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 502025017956 putative molybdopterin cofactor binding site; other site 502025017957 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025017958 active site 502025017959 substrate binding sites [chemical binding]; other site 502025017960 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 502025017961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025017962 dimerization interface [polypeptide binding]; other site 502025017963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017964 dimer interface [polypeptide binding]; other site 502025017965 phosphorylation site [posttranslational modification] 502025017966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017967 ATP binding site [chemical binding]; other site 502025017968 Mg2+ binding site [ion binding]; other site 502025017969 G-X-G motif; other site 502025017970 haloalkane dehalogenase; Provisional; Region: PRK00870 502025017971 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025017972 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025017973 P-loop; other site 502025017974 Magnesium ion binding site [ion binding]; other site 502025017975 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025017976 Magnesium ion binding site [ion binding]; other site 502025017977 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017979 active site 502025017980 phosphorylation site [posttranslational modification] 502025017981 intermolecular recognition site; other site 502025017982 dimerization interface [polypeptide binding]; other site 502025017983 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025017984 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025017985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017986 dimer interface [polypeptide binding]; other site 502025017987 phosphorylation site [posttranslational modification] 502025017988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017989 ATP binding site [chemical binding]; other site 502025017990 Mg2+ binding site [ion binding]; other site 502025017991 G-X-G motif; other site 502025017992 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 502025017993 substrate binding site [chemical binding]; other site 502025017994 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025017995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025017996 RNA binding surface [nucleotide binding]; other site 502025017997 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025017998 active site 502025017999 tyramine oxidase; Provisional; Region: tynA; PRK11504 502025018000 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025018001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025018002 ATP binding site [chemical binding]; other site 502025018003 putative Mg++ binding site [ion binding]; other site 502025018004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025018005 nucleotide binding region [chemical binding]; other site 502025018006 ATP-binding site [chemical binding]; other site 502025018007 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 502025018008 HRDC domain; Region: HRDC; cl02578 502025018009 Predicted permease; Region: DUF318; pfam03773 502025018010 Predicted permease; Region: DUF318; pfam03773 502025018011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025018012 non-specific DNA binding site [nucleotide binding]; other site 502025018013 salt bridge; other site 502025018014 sequence-specific DNA binding site [nucleotide binding]; other site 502025018015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025018016 non-specific DNA binding site [nucleotide binding]; other site 502025018017 salt bridge; other site 502025018018 sequence-specific DNA binding site [nucleotide binding]; other site 502025018019 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025018020 TPR repeat; Region: TPR_11; pfam13414 502025018021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018022 binding surface 502025018023 TPR motif; other site 502025018024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018025 binding surface 502025018026 TPR motif; other site 502025018027 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 502025018028 SmpB-tmRNA interface; other site 502025018029 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 502025018030 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 502025018031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018032 Walker A motif; other site 502025018033 ATP binding site [chemical binding]; other site 502025018034 Walker B motif; other site 502025018035 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 502025018036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025018037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025018038 DNA binding site [nucleotide binding] 502025018039 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 502025018040 MgtE intracellular N domain; Region: MgtE_N; cl15244 502025018041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 502025018042 Divalent cation transporter; Region: MgtE; cl00786 502025018043 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 502025018044 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025018045 active site 502025018046 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025018047 ligand binding site [chemical binding]; other site 502025018048 flexible hinge region; other site 502025018049 Chorismate mutase type II; Region: CM_2; cl00693 502025018050 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 502025018051 Prephenate dehydratase; Region: PDT; pfam00800 502025018052 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 502025018053 putative L-Phe binding site [chemical binding]; other site 502025018054 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 502025018055 Prostaglandin dehydrogenases; Region: PGDH; cd05288 502025018056 NAD(P) binding site [chemical binding]; other site 502025018057 substrate binding site [chemical binding]; other site 502025018058 dimer interface [polypeptide binding]; other site 502025018059 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025018060 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 502025018061 C-terminal domain interface [polypeptide binding]; other site 502025018062 GSH binding site (G-site) [chemical binding]; other site 502025018063 dimer interface [polypeptide binding]; other site 502025018064 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025018065 N-terminal domain interface [polypeptide binding]; other site 502025018066 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 502025018067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025018068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 502025018069 FOG: CBS domain [General function prediction only]; Region: COG0517 502025018070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025018071 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 502025018072 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 502025018073 NADP binding site [chemical binding]; other site 502025018074 homodimer interface [polypeptide binding]; other site 502025018075 active site 502025018076 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 502025018077 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 502025018078 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 502025018079 putative trimer interface [polypeptide binding]; other site 502025018080 putative active site [active] 502025018081 putative substrate binding site [chemical binding]; other site 502025018082 putative CoA binding site [chemical binding]; other site 502025018083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025018084 superoxide dismutase; Provisional; Region: PRK10543 502025018085 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 502025018086 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 502025018087 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 502025018088 dimer interface [polypeptide binding]; other site 502025018089 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 502025018090 EVE domain; Region: EVE; cl00728 502025018091 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025018092 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 502025018093 active site 502025018094 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025018095 catalytic residues [active] 502025018096 Sulfatase; Region: Sulfatase; cl10460 502025018097 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 502025018098 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 502025018099 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 502025018100 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 502025018101 active site 502025018102 Zn binding site [ion binding]; other site 502025018103 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 502025018104 G1 box; other site 502025018105 GTP/Mg2+ binding site [chemical binding]; other site 502025018106 G2 box; other site 502025018107 Switch I region; other site 502025018108 G3 box; other site 502025018109 Switch II region; other site 502025018110 G4 box; other site 502025018111 G5 box; other site 502025018112 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 502025018113 recombination protein RecR; Reviewed; Region: recR; PRK00076 502025018114 RecR protein; Region: RecR; pfam02132 502025018115 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 502025018116 putative active site [active] 502025018117 putative metal-binding site [ion binding]; other site 502025018118 tetramer interface [polypeptide binding]; other site 502025018119 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 502025018120 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 502025018121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018122 Walker A motif; other site 502025018123 ATP binding site [chemical binding]; other site 502025018124 Walker B motif; other site 502025018125 arginine finger; other site 502025018126 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 502025018127 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 502025018128 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 502025018129 nucleoside/Zn binding site; other site 502025018130 dimer interface [polypeptide binding]; other site 502025018131 catalytic motif [active] 502025018132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018133 binding surface 502025018134 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025018135 TPR motif; other site 502025018136 tetratricopeptide repeat protein; Provisional; Region: PRK11788 502025018137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018138 TPR motif; other site 502025018139 binding surface 502025018140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018141 TPR motif; other site 502025018142 binding surface 502025018143 TPR repeat; Region: TPR_11; pfam13414 502025018144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018145 binding surface 502025018146 TPR motif; other site 502025018147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018148 TPR motif; other site 502025018149 TPR repeat; Region: TPR_11; pfam13414 502025018150 binding surface 502025018151 TPR repeat; Region: TPR_11; pfam13414 502025018152 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 502025018153 catalytic center binding site [active] 502025018154 ATP binding site [chemical binding]; other site 502025018155 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025018156 phosphopeptide binding site; other site 502025018157 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018159 active site 502025018160 phosphorylation site [posttranslational modification] 502025018161 intermolecular recognition site; other site 502025018162 dimerization interface [polypeptide binding]; other site 502025018163 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 502025018164 Peptidase family M48; Region: Peptidase_M48; cl12018 502025018165 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 502025018166 Dynamin family; Region: Dynamin_N; pfam00350 502025018167 G1 box; other site 502025018168 GTP/Mg2+ binding site [chemical binding]; other site 502025018169 G2 box; other site 502025018170 Switch I region; other site 502025018171 G3 box; other site 502025018172 Switch II region; other site 502025018173 G4 box; other site 502025018174 G5 box; other site 502025018175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018176 binding surface 502025018177 TPR motif; other site 502025018178 TPR repeat; Region: TPR_11; pfam13414 502025018179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025018180 TPR motif; other site 502025018181 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 502025018182 Dynamin family; Region: Dynamin_N; pfam00350 502025018183 G1 box; other site 502025018184 GTP/Mg2+ binding site [chemical binding]; other site 502025018185 G2 box; other site 502025018186 Switch I region; other site 502025018187 G3 box; other site 502025018188 Switch II region; other site 502025018189 G4 box; other site 502025018190 G5 box; other site 502025018191 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 502025018192 RNA/DNA hybrid binding site [nucleotide binding]; other site 502025018193 active site 502025018194 RNA polymerase sigma factor; Provisional; Region: PRK12513 502025018195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025018196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025018197 DNA binding residues [nucleotide binding] 502025018198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025018199 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 502025018200 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 502025018201 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 502025018202 DNA binding site [nucleotide binding] 502025018203 catalytic residue [active] 502025018204 H2TH interface [polypeptide binding]; other site 502025018205 putative catalytic residues [active] 502025018206 turnover-facilitating residue; other site 502025018207 intercalation triad [nucleotide binding]; other site 502025018208 8OG recognition residue [nucleotide binding]; other site 502025018209 putative reading head residues; other site 502025018210 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 502025018211 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 502025018212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025018213 UGMP family protein; Validated; Region: PRK09604 502025018214 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 502025018215 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018217 active site 502025018218 phosphorylation site [posttranslational modification] 502025018219 intermolecular recognition site; other site 502025018220 dimerization interface [polypeptide binding]; other site 502025018221 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025018222 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 502025018223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 502025018224 AAA domain; Region: AAA_26; pfam13500 502025018225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025018226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 502025018227 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 502025018228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025018229 inhibitor-cofactor binding pocket; inhibition site 502025018230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025018231 catalytic residue [active] 502025018232 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 502025018233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025018234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025018235 catalytic residue [active] 502025018236 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 502025018237 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 502025018238 trmE is a tRNA modification GTPase; Region: trmE; cd04164 502025018239 G1 box; other site 502025018240 GTP/Mg2+ binding site [chemical binding]; other site 502025018241 Switch I region; other site 502025018242 G2 box; other site 502025018243 Switch II region; other site 502025018244 G3 box; other site 502025018245 G4 box; other site 502025018246 G5 box; other site 502025018247 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 502025018248 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 502025018249 G-X-X-G motif; other site 502025018250 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 502025018251 RxxxH motif; other site 502025018252 membrane protein insertase; Provisional; Region: PRK01318 502025018253 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 502025018254 Haemolytic domain; Region: Haemolytic; cl00506