-- dump date 20120504_145918 -- class Genbank::misc_feature -- table misc_feature_note -- id note 373903000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 373903000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 373903000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903000004 Walker A motif; other site 373903000005 ATP binding site [chemical binding]; other site 373903000006 Walker B motif; other site 373903000007 arginine finger; other site 373903000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 373903000009 DnaA box-binding interface [nucleotide binding]; other site 373903000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 373903000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 373903000012 putative DNA binding surface [nucleotide binding]; other site 373903000013 dimer interface [polypeptide binding]; other site 373903000014 beta-clamp/clamp loader binding surface; other site 373903000015 beta-clamp/translesion DNA polymerase binding surface; other site 373903000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373903000017 RNA binding surface [nucleotide binding]; other site 373903000018 recombination protein F; Reviewed; Region: recF; PRK00064 373903000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 373903000020 Walker A/P-loop; other site 373903000021 ATP binding site [chemical binding]; other site 373903000022 Q-loop/lid; other site 373903000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000024 ABC transporter signature motif; other site 373903000025 Walker B; other site 373903000026 D-loop; other site 373903000027 H-loop/switch region; other site 373903000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 373903000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 373903000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 373903000031 anchoring element; other site 373903000032 dimer interface [polypeptide binding]; other site 373903000033 ATP binding site [chemical binding]; other site 373903000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 373903000035 active site 373903000036 putative metal-binding site [ion binding]; other site 373903000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373903000038 DNA gyrase subunit A; Validated; Region: PRK05560 373903000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 373903000040 CAP-like domain; other site 373903000041 active site 373903000042 primary dimer interface [polypeptide binding]; other site 373903000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903000049 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 373903000050 ligand binding site [chemical binding]; other site 373903000051 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 373903000052 Spore germination protein; Region: Spore_permease; cl15802 373903000053 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 373903000054 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 373903000055 putative oxidoreductase FixC; Provisional; Region: PRK10157 373903000056 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373903000057 dinuclear metal binding motif [ion binding]; other site 373903000058 Short C-terminal domain; Region: SHOCT; cl01373 373903000059 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 373903000060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373903000061 ABC-ATPase subunit interface; other site 373903000062 dimer interface [polypeptide binding]; other site 373903000063 putative PBP binding regions; other site 373903000064 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 373903000065 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373903000066 Walker A/P-loop; other site 373903000067 ATP binding site [chemical binding]; other site 373903000068 Q-loop/lid; other site 373903000069 ABC transporter signature motif; other site 373903000070 Walker B; other site 373903000071 D-loop; other site 373903000072 H-loop/switch region; other site 373903000073 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373903000074 Fic/DOC family; Region: Fic; cl00960 373903000075 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 373903000076 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 373903000077 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903000078 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 373903000079 Helix-turn-helix domains; Region: HTH; cl00088 373903000080 putative transposase OrfB; Reviewed; Region: PHA02517 373903000081 HTH-like domain; Region: HTH_21; pfam13276 373903000082 Integrase core domain; Region: rve; cl01316 373903000083 Integrase core domain; Region: rve_3; cl15866 373903000084 CAAX protease self-immunity; Region: Abi; cl00558 373903000085 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 373903000086 putative active site [active] 373903000087 homotetrameric interface [polypeptide binding]; other site 373903000088 metal binding site [ion binding]; metal-binding site 373903000089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373903000090 Coenzyme A binding pocket [chemical binding]; other site 373903000091 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 373903000092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903000093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903000094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 373903000095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903000096 putative PBP binding loops; other site 373903000097 ABC-ATPase subunit interface; other site 373903000098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903000099 dimer interface [polypeptide binding]; other site 373903000100 conserved gate region; other site 373903000101 putative PBP binding loops; other site 373903000102 ABC-ATPase subunit interface; other site 373903000103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903000104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903000105 DNA binding site [nucleotide binding] 373903000106 domain linker motif; other site 373903000107 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903000108 dimerization interface [polypeptide binding]; other site 373903000109 ligand binding site [chemical binding]; other site 373903000110 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373903000111 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373903000112 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373903000113 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373903000114 beta-phosphoglucomutase; Region: bPGM; TIGR01990 373903000115 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903000116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903000117 motif II; other site 373903000118 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903000119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903000120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903000121 DNA binding site [nucleotide binding] 373903000122 domain linker motif; other site 373903000123 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903000124 dimerization interface [polypeptide binding]; other site 373903000125 ligand binding site [chemical binding]; other site 373903000126 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 373903000127 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 373903000128 Walker A/P-loop; other site 373903000129 ATP binding site [chemical binding]; other site 373903000130 Q-loop/lid; other site 373903000131 ABC transporter signature motif; other site 373903000132 Walker B; other site 373903000133 D-loop; other site 373903000134 H-loop/switch region; other site 373903000135 TOBE domain; Region: TOBE_2; cl01440 373903000136 YabP family; Region: YabP; cl06766 373903000137 two-component sensor protein; Provisional; Region: cpxA; PRK09470 373903000138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903000139 dimerization interface [polypeptide binding]; other site 373903000140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903000141 dimer interface [polypeptide binding]; other site 373903000142 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903000143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903000144 dimer interface [polypeptide binding]; other site 373903000145 putative CheW interface [polypeptide binding]; other site 373903000146 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 373903000147 Septum formation initiator; Region: DivIC; cl11433 373903000148 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 373903000149 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 373903000150 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 373903000151 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 373903000152 RNA binding site [nucleotide binding]; other site 373903000153 hypothetical protein; Provisional; Region: PRK08582 373903000154 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 373903000155 RNA binding site [nucleotide binding]; other site 373903000156 Protein of unknown function (DUF501); Region: DUF501; cl00652 373903000157 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 373903000158 stage II sporulation protein E; Region: spore_II_E; TIGR02865 373903000159 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 373903000160 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 373903000161 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 373903000162 Ligand Binding Site [chemical binding]; other site 373903000163 B3/4 domain; Region: B3_4; cl11458 373903000164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903000165 active site 373903000166 FtsH Extracellular; Region: FtsH_ext; pfam06480 373903000167 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 373903000168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903000169 Walker A motif; other site 373903000170 ATP binding site [chemical binding]; other site 373903000171 Walker B motif; other site 373903000172 arginine finger; other site 373903000173 Peptidase family M41; Region: Peptidase_M41; pfam01434 373903000174 Sodium:solute symporter family; Region: SSF; cl00456 373903000175 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 373903000176 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 373903000177 Potassium binding sites [ion binding]; other site 373903000178 Cesium cation binding sites [ion binding]; other site 373903000179 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903000180 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 373903000181 Quinolinate synthetase A protein; Region: NadA; cl00420 373903000182 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 373903000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000184 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373903000185 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 373903000186 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 373903000187 dimerization interface [polypeptide binding]; other site 373903000188 active site 373903000189 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 373903000190 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373903000191 protein binding site [polypeptide binding]; other site 373903000192 Helix-turn-helix domains; Region: HTH; cl00088 373903000193 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 373903000194 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 373903000195 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 373903000196 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 373903000197 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 373903000198 ligand binding site [chemical binding]; other site 373903000199 Type III pantothenate kinase; Region: Pan_kinase; cl09130 373903000200 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 373903000201 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373903000202 FMN binding site [chemical binding]; other site 373903000203 active site 373903000204 catalytic residues [active] 373903000205 substrate binding site [chemical binding]; other site 373903000206 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373903000207 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 373903000208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373903000209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903000210 Transcriptional regulator [DNA replication, recombination and repair]; Region: tfx; COG1356 373903000211 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373903000212 Predicted dehydrogenase [General function prediction only]; Region: COG5322 373903000213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000214 NAD(P) binding pocket [chemical binding]; other site 373903000215 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 373903000216 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 373903000217 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 373903000218 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 373903000219 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 373903000220 dimer interface [polypeptide binding]; other site 373903000221 putative anticodon binding site; other site 373903000222 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 373903000223 motif 1; other site 373903000224 active site 373903000225 motif 2; other site 373903000226 motif 3; other site 373903000227 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 373903000228 Helix-turn-helix domains; Region: HTH; cl00088 373903000229 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373903000230 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903000231 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903000232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903000233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903000234 dimer interface [polypeptide binding]; other site 373903000235 conserved gate region; other site 373903000236 putative PBP binding loops; other site 373903000237 ABC-ATPase subunit interface; other site 373903000238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903000239 dimer interface [polypeptide binding]; other site 373903000240 conserved gate region; other site 373903000241 putative PBP binding loops; other site 373903000242 ABC-ATPase subunit interface; other site 373903000243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000244 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 373903000245 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 373903000246 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 373903000247 UvrB/uvrC motif; Region: UVR; pfam02151 373903000248 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 373903000249 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 373903000250 ADP binding site [chemical binding]; other site 373903000251 phosphagen binding site; other site 373903000252 substrate specificity loop; other site 373903000253 Clp protease ATP binding subunit; Region: clpC; CHL00095 373903000254 Clp amino terminal domain; Region: Clp_N; pfam02861 373903000255 Clp amino terminal domain; Region: Clp_N; pfam02861 373903000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903000257 Walker A motif; other site 373903000258 ATP binding site [chemical binding]; other site 373903000259 Walker B motif; other site 373903000260 arginine finger; other site 373903000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903000262 Walker A motif; other site 373903000263 ATP binding site [chemical binding]; other site 373903000264 Walker B motif; other site 373903000265 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 373903000266 DNA repair protein RadA; Provisional; Region: PRK11823 373903000267 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 373903000268 Walker A motif/ATP binding site; other site 373903000269 ATP binding site [chemical binding]; other site 373903000270 Walker B motif; other site 373903000271 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903000272 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 373903000273 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 373903000274 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 373903000275 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 373903000276 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 373903000277 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 373903000278 putative active site [active] 373903000279 TRAM domain; Region: TRAM; cl01282 373903000280 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 373903000281 substrate binding site; other site 373903000282 dimer interface; other site 373903000283 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 373903000284 homotrimer interaction site [polypeptide binding]; other site 373903000285 zinc binding site [ion binding]; other site 373903000286 CDP-binding sites; other site 373903000287 FOG: CBS domain [General function prediction only]; Region: COG0517 373903000288 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_3; cd04802 373903000289 HutP; Region: HutP; cl07944 373903000290 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 373903000291 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373903000292 active site 373903000293 HIGH motif; other site 373903000294 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373903000295 active site 373903000296 KMSKS motif; other site 373903000297 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 373903000298 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373903000299 active site 373903000300 HIGH motif; other site 373903000301 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373903000302 KMSKS motif; other site 373903000303 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 373903000304 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373903000305 active site 373903000306 metal binding site [ion binding]; metal-binding site 373903000307 dimerization interface [polypeptide binding]; other site 373903000308 Thymidylate synthase complementing protein; Region: Thy1; cl03630 373903000309 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 373903000310 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 373903000311 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 373903000312 RNA polymerase factor sigma-70; Validated; Region: PRK08295 373903000313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903000314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903000315 elongation factor Tu; Reviewed; Region: PRK00049 373903000316 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 373903000317 G1 box; other site 373903000318 GEF interaction site [polypeptide binding]; other site 373903000319 GTP/Mg2+ binding site [chemical binding]; other site 373903000320 Switch I region; other site 373903000321 G2 box; other site 373903000322 G3 box; other site 373903000323 Switch II region; other site 373903000324 G4 box; other site 373903000325 G5 box; other site 373903000326 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 373903000327 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 373903000328 Antibiotic Binding Site [chemical binding]; other site 373903000329 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 373903000330 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 373903000331 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 373903000332 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 373903000333 putative homodimer interface [polypeptide binding]; other site 373903000334 KOW motif; Region: KOW; cl00354 373903000335 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 373903000336 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 373903000337 23S rRNA interface [nucleotide binding]; other site 373903000338 L7/L12 interface [polypeptide binding]; other site 373903000339 putative thiostrepton binding site; other site 373903000340 L25 interface [polypeptide binding]; other site 373903000341 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 373903000342 mRNA/rRNA interface [nucleotide binding]; other site 373903000343 Ribosomal protein L10 leader 373903000344 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 373903000345 23S rRNA interface [nucleotide binding]; other site 373903000346 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 373903000347 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 373903000348 L11 interface [polypeptide binding]; other site 373903000349 putative EF-Tu interaction site [polypeptide binding]; other site 373903000350 putative EF-G interaction site [polypeptide binding]; other site 373903000351 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 373903000352 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 373903000353 RPB12 interaction site [polypeptide binding]; other site 373903000354 RPB1 interaction site [polypeptide binding]; other site 373903000355 RPB10 interaction site [polypeptide binding]; other site 373903000356 RPB11 interaction site [polypeptide binding]; other site 373903000357 RPB3 interaction site [polypeptide binding]; other site 373903000358 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 373903000359 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 373903000360 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 373903000361 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 373903000362 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 373903000363 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 373903000364 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 373903000365 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 373903000366 G-loop; other site 373903000367 DNA binding site [nucleotide binding] 373903000368 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 373903000369 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 373903000370 S17 interaction site [polypeptide binding]; other site 373903000371 S8 interaction site; other site 373903000372 16S rRNA interaction site [nucleotide binding]; other site 373903000373 streptomycin interaction site [chemical binding]; other site 373903000374 23S rRNA interaction site [nucleotide binding]; other site 373903000375 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 373903000376 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 373903000377 elongation factor G; Reviewed; Region: PRK00007 373903000378 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 373903000379 G1 box; other site 373903000380 putative GEF interaction site [polypeptide binding]; other site 373903000381 GTP/Mg2+ binding site [chemical binding]; other site 373903000382 Switch I region; other site 373903000383 G2 box; other site 373903000384 G3 box; other site 373903000385 Switch II region; other site 373903000386 G4 box; other site 373903000387 G5 box; other site 373903000388 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373903000389 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373903000390 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373903000391 elongation factor Tu; Reviewed; Region: PRK00049 373903000392 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 373903000393 G1 box; other site 373903000394 GEF interaction site [polypeptide binding]; other site 373903000395 GTP/Mg2+ binding site [chemical binding]; other site 373903000396 Switch I region; other site 373903000397 G2 box; other site 373903000398 G3 box; other site 373903000399 Switch II region; other site 373903000400 G4 box; other site 373903000401 G5 box; other site 373903000402 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 373903000403 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 373903000404 Antibiotic Binding Site [chemical binding]; other site 373903000405 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 373903000406 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 373903000407 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 373903000408 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 373903000409 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 373903000410 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 373903000411 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 373903000412 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 373903000413 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 373903000414 putative translocon binding site; other site 373903000415 protein-rRNA interface [nucleotide binding]; other site 373903000416 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 373903000417 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 373903000418 G-X-X-G motif; other site 373903000419 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 373903000420 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 373903000421 23S rRNA interface [nucleotide binding]; other site 373903000422 5S rRNA interface [nucleotide binding]; other site 373903000423 putative antibiotic binding site [chemical binding]; other site 373903000424 L25 interface [polypeptide binding]; other site 373903000425 L27 interface [polypeptide binding]; other site 373903000426 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 373903000427 putative translocon interaction site; other site 373903000428 23S rRNA interface [nucleotide binding]; other site 373903000429 signal recognition particle (SRP54) interaction site; other site 373903000430 L23 interface [polypeptide binding]; other site 373903000431 trigger factor interaction site; other site 373903000432 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 373903000433 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 373903000434 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 373903000435 KOW motif; Region: KOW; cl00354 373903000436 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 373903000437 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 373903000438 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 373903000439 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 373903000440 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 373903000441 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 373903000442 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373903000443 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373903000444 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 373903000445 5S rRNA interface [nucleotide binding]; other site 373903000446 L27 interface [polypeptide binding]; other site 373903000447 23S rRNA interface [nucleotide binding]; other site 373903000448 L5 interface [polypeptide binding]; other site 373903000449 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 373903000450 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 373903000451 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 373903000452 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 373903000453 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 373903000454 SecY translocase; Region: SecY; pfam00344 373903000455 adenylate kinase; Reviewed; Region: adk; PRK00279 373903000456 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 373903000457 AMP-binding site [chemical binding]; other site 373903000458 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 373903000459 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 373903000460 active site 373903000461 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 373903000462 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 373903000463 rRNA binding site [nucleotide binding]; other site 373903000464 predicted 30S ribosome binding site; other site 373903000465 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 373903000466 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 373903000467 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 373903000468 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 373903000469 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 373903000470 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 373903000471 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373903000472 RNA binding surface [nucleotide binding]; other site 373903000473 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 373903000474 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 373903000475 alphaNTD - beta interaction site [polypeptide binding]; other site 373903000476 alphaNTD homodimer interface [polypeptide binding]; other site 373903000477 alphaNTD - beta' interaction site [polypeptide binding]; other site 373903000478 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 373903000479 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 373903000480 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 373903000481 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 373903000482 Walker A/P-loop; other site 373903000483 ATP binding site [chemical binding]; other site 373903000484 Q-loop/lid; other site 373903000485 ABC transporter signature motif; other site 373903000486 Walker B; other site 373903000487 D-loop; other site 373903000488 H-loop/switch region; other site 373903000489 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 373903000490 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 373903000491 Walker A/P-loop; other site 373903000492 ATP binding site [chemical binding]; other site 373903000493 Q-loop/lid; other site 373903000494 ABC transporter signature motif; other site 373903000495 Walker B; other site 373903000496 D-loop; other site 373903000497 H-loop/switch region; other site 373903000498 Cobalt transport protein; Region: CbiQ; cl00463 373903000499 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 373903000500 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 373903000501 dimerization interface 3.5A [polypeptide binding]; other site 373903000502 active site 373903000503 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 373903000504 23S rRNA interface [nucleotide binding]; other site 373903000505 L3 interface [polypeptide binding]; other site 373903000506 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 373903000507 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 373903000508 AMMECR1; Region: AMMECR1; cl00911 373903000509 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 373903000510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903000511 FeS/SAM binding site; other site 373903000512 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 373903000513 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 373903000514 active site 373903000515 substrate binding site [chemical binding]; other site 373903000516 metal binding site [ion binding]; metal-binding site 373903000517 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 373903000518 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 373903000519 glutaminase active site [active] 373903000520 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373903000521 DNA binding residues [nucleotide binding] 373903000522 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 373903000523 dimer interface [polypeptide binding]; other site 373903000524 active site 373903000525 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 373903000526 dimer interface [polypeptide binding]; other site 373903000527 active site 373903000528 ADP-glucose phosphorylase; Region: PLN02643 373903000529 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 373903000530 dimer interface [polypeptide binding]; other site 373903000531 active site 373903000532 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 373903000533 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 373903000534 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373903000535 Accessory gene regulator B; Region: AgrB; cl01873 373903000536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903000537 ATP binding site [chemical binding]; other site 373903000538 Mg2+ binding site [ion binding]; other site 373903000539 G-X-G motif; other site 373903000540 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 373903000541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903000542 active site 373903000543 phosphorylation site [posttranslational modification] 373903000544 intermolecular recognition site; other site 373903000545 dimerization interface [polypeptide binding]; other site 373903000546 LytTr DNA-binding domain; Region: LytTR; cl04498 373903000547 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 373903000548 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 373903000549 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 373903000550 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 373903000551 putative substrate binding site [chemical binding]; other site 373903000552 putative ATP binding site [chemical binding]; other site 373903000553 alanine racemase; Reviewed; Region: alr; PRK00053 373903000554 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 373903000555 active site 373903000556 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373903000557 dimer interface [polypeptide binding]; other site 373903000558 substrate binding site [chemical binding]; other site 373903000559 catalytic residues [active] 373903000560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373903000561 dimerization domain swap beta strand [polypeptide binding]; other site 373903000562 regulatory protein interface [polypeptide binding]; other site 373903000563 active site 373903000564 regulatory phosphorylation site [posttranslational modification]; other site 373903000565 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 373903000566 trimer interface [polypeptide binding]; other site 373903000567 active site 373903000568 DbpA RNA binding domain; Region: DbpA; pfam03880 373903000569 DNA helicase, putative; Region: TIGR00376 373903000570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000571 Family description; Region: UvrD_C_2; cl15862 373903000572 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 373903000573 PemK-like protein; Region: PemK; cl00995 373903000574 L-asparaginase II; Region: Asparaginase_II; cl01842 373903000575 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 373903000576 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 373903000577 active site 373903000578 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903000579 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000580 Putative Fe-S cluster; Region: FeS; pfam04060 373903000581 PAS fold; Region: PAS_4; pfam08448 373903000582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903000583 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 373903000584 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 373903000585 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 373903000586 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 373903000587 putative dimer interface [polypeptide binding]; other site 373903000588 [2Fe-2S] cluster binding site [ion binding]; other site 373903000589 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373903000590 dimer interface [polypeptide binding]; other site 373903000591 [2Fe-2S] cluster binding site [ion binding]; other site 373903000592 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 373903000593 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 373903000594 SLBB domain; Region: SLBB; pfam10531 373903000595 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 373903000596 4Fe-4S binding domain; Region: Fer4; cl02805 373903000597 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 373903000598 4Fe-4S binding domain; Region: Fer4; cl02805 373903000599 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 373903000600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 373903000601 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 373903000602 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903000603 4Fe-4S binding domain; Region: Fer4; cl02805 373903000604 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000605 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 373903000606 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373903000607 [2Fe-2S] cluster binding site [ion binding]; other site 373903000608 dimer interface [polypeptide binding]; other site 373903000609 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 373903000610 AzlC protein; Region: AzlC; cl00570 373903000611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373903000612 sequence-specific DNA binding site [nucleotide binding]; other site 373903000613 salt bridge; other site 373903000614 Cupin domain; Region: Cupin_2; cl09118 373903000615 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 373903000616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373903000617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903000618 homodimer interface [polypeptide binding]; other site 373903000619 catalytic residue [active] 373903000620 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 373903000621 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 373903000622 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 373903000623 A new structural DNA glycosylase; Region: AlkD_like; cd06561 373903000624 active site 373903000625 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 373903000626 diiron binding motif [ion binding]; other site 373903000627 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 373903000628 T-box leader 373903000629 prephenate dehydratase; Provisional; Region: PRK11898 373903000630 Prephenate dehydratase; Region: PDT; pfam00800 373903000631 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 373903000632 putative L-Phe binding site [chemical binding]; other site 373903000633 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 373903000634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373903000635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903000636 homodimer interface [polypeptide binding]; other site 373903000637 catalytic residue [active] 373903000638 gamma-glutamyl kinase; Provisional; Region: PRK05429 373903000639 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 373903000640 nucleotide binding site [chemical binding]; other site 373903000641 homotetrameric interface [polypeptide binding]; other site 373903000642 putative phosphate binding site [ion binding]; other site 373903000643 putative allosteric binding site; other site 373903000644 PUA domain; Region: PUA; cl00607 373903000645 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 373903000646 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 373903000647 putative catalytic cysteine [active] 373903000648 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 373903000649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000650 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 373903000651 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 373903000652 Glycoprotease family; Region: Peptidase_M22; pfam00814 373903000653 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 373903000654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373903000655 Coenzyme A binding pocket [chemical binding]; other site 373903000656 UGMP family protein; Validated; Region: PRK09604 373903000657 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 373903000658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903000659 Radical SAM superfamily; Region: Radical_SAM; pfam04055 373903000660 FeS/SAM binding site; other site 373903000661 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373903000662 Protein of unknown function (DUF512); Region: DUF512; pfam04459 373903000663 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 373903000664 oligomerisation interface [polypeptide binding]; other site 373903000665 mobile loop; other site 373903000666 roof hairpin; other site 373903000667 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 373903000668 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 373903000669 ring oligomerisation interface [polypeptide binding]; other site 373903000670 ATP/Mg binding site [chemical binding]; other site 373903000671 stacking interactions; other site 373903000672 hinge regions; other site 373903000673 GMP synthase; Reviewed; Region: guaA; PRK00074 373903000674 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 373903000675 AMP/PPi binding site [chemical binding]; other site 373903000676 candidate oxyanion hole; other site 373903000677 catalytic triad [active] 373903000678 potential glutamine specificity residues [chemical binding]; other site 373903000679 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 373903000680 ATP Binding subdomain [chemical binding]; other site 373903000681 Ligand Binding sites [chemical binding]; other site 373903000682 Dimerization subdomain; other site 373903000683 Helix-turn-helix domains; Region: HTH; cl00088 373903000684 Domain of unknown function (DUF389); Region: DUF389; cl00781 373903000685 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903000686 4Fe-4S binding domain; Region: Fer4; cl02805 373903000687 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000688 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 373903000689 Putative Fe-S cluster; Region: FeS; pfam04060 373903000690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903000691 PAS domain; Region: PAS_9; pfam13426 373903000692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 373903000693 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 373903000694 putative dimer interface [polypeptide binding]; other site 373903000695 [2Fe-2S] cluster binding site [ion binding]; other site 373903000696 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 373903000697 4Fe-4S binding domain; Region: Fer4; cl02805 373903000698 4Fe-4S binding domain; Region: Fer4; cl02805 373903000699 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000700 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 373903000701 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 373903000702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000703 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 373903000704 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 373903000705 putative catalytic cysteine [active] 373903000706 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 373903000707 putative active site [active] 373903000708 metal binding site [ion binding]; metal-binding site 373903000709 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 373903000710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000711 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373903000712 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 373903000713 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 373903000714 Protease prsW family; Region: PrsW-protease; cl15823 373903000715 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 373903000716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000717 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 373903000718 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373903000719 minor groove reading motif; other site 373903000720 helix-hairpin-helix signature motif; other site 373903000721 substrate binding pocket [chemical binding]; other site 373903000722 active site 373903000723 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 373903000724 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 373903000725 dimer interface [polypeptide binding]; other site 373903000726 motif 1; other site 373903000727 active site 373903000728 motif 2; other site 373903000729 motif 3; other site 373903000730 ATP phosphoribosyltransferase; Region: HisG; cl15266 373903000731 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 373903000732 histidinol dehydrogenase; Region: hisD; TIGR00069 373903000733 NAD binding site [chemical binding]; other site 373903000734 dimerization interface [polypeptide binding]; other site 373903000735 product binding site; other site 373903000736 substrate binding site [chemical binding]; other site 373903000737 zinc binding site [ion binding]; other site 373903000738 catalytic residues [active] 373903000739 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 373903000740 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 373903000741 4-fold oligomerization interface [polypeptide binding]; other site 373903000742 putative active site pocket [active] 373903000743 metal binding residues [ion binding]; metal-binding site 373903000744 3-fold/trimer interface [polypeptide binding]; other site 373903000745 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 373903000746 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 373903000747 putative active site [active] 373903000748 oxyanion strand; other site 373903000749 catalytic triad [active] 373903000750 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 373903000751 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 373903000752 catalytic residues [active] 373903000753 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 373903000754 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 373903000755 substrate binding site [chemical binding]; other site 373903000756 glutamase interaction surface [polypeptide binding]; other site 373903000757 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 373903000758 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 373903000759 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 373903000760 Coat F domain; Region: Coat_F; cl15836 373903000761 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 373903000762 GIY-YIG motif/motif A; other site 373903000763 putative active site [active] 373903000764 putative metal binding site [ion binding]; other site 373903000765 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 373903000766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000767 Family description; Region: UvrD_C_2; cl15862 373903000768 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 373903000769 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 373903000770 nucleotide binding pocket [chemical binding]; other site 373903000771 K-X-D-G motif; other site 373903000772 catalytic site [active] 373903000773 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 373903000774 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 373903000775 Dimer interface [polypeptide binding]; other site 373903000776 BRCT sequence motif; other site 373903000777 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 373903000778 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 373903000779 Amidase; Region: Amidase; cl11426 373903000780 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 373903000781 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 373903000782 GatB domain; Region: GatB_Yqey; cl11497 373903000783 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 373903000784 ABC-2 type transporter; Region: ABC2_membrane; cl11417 373903000785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373903000786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000787 Walker A/P-loop; other site 373903000788 ATP binding site [chemical binding]; other site 373903000789 Q-loop/lid; other site 373903000790 ABC transporter signature motif; other site 373903000791 Walker B; other site 373903000792 D-loop; other site 373903000793 H-loop/switch region; other site 373903000794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903000795 dimerization interface [polypeptide binding]; other site 373903000796 putative DNA binding site [nucleotide binding]; other site 373903000797 putative Zn2+ binding site [ion binding]; other site 373903000798 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 373903000799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373903000800 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373903000801 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 373903000802 active site residue [active] 373903000803 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 373903000804 CPxP motif; other site 373903000805 DsrE/DsrF-like family; Region: DrsE; cl00672 373903000806 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 373903000807 active site 373903000808 catalytic site [active] 373903000809 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 373903000810 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 373903000811 Walker A/P-loop; other site 373903000812 ATP binding site [chemical binding]; other site 373903000813 Q-loop/lid; other site 373903000814 ABC transporter signature motif; other site 373903000815 Walker B; other site 373903000816 D-loop; other site 373903000817 H-loop/switch region; other site 373903000818 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 373903000819 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 373903000820 Walker A/P-loop; other site 373903000821 ATP binding site [chemical binding]; other site 373903000822 Q-loop/lid; other site 373903000823 ABC transporter signature motif; other site 373903000824 Walker B; other site 373903000825 D-loop; other site 373903000826 H-loop/switch region; other site 373903000827 Cobalt transport protein; Region: CbiQ; cl00463 373903000828 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 373903000829 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 373903000830 dimerization interface 3.5A [polypeptide binding]; other site 373903000831 active site 373903000832 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 373903000833 23S rRNA interface [nucleotide binding]; other site 373903000834 L3 interface [polypeptide binding]; other site 373903000835 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 373903000836 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 373903000837 AMMECR1; Region: AMMECR1; cl00911 373903000838 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 373903000839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903000840 FeS/SAM binding site; other site 373903000841 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 373903000842 Outer membrane efflux protein; Region: OEP; pfam02321 373903000843 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 373903000844 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373903000845 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373903000846 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 373903000847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373903000848 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 373903000849 Walker A/P-loop; other site 373903000850 ATP binding site [chemical binding]; other site 373903000851 Q-loop/lid; other site 373903000852 ABC transporter signature motif; other site 373903000853 Walker B; other site 373903000854 D-loop; other site 373903000855 H-loop/switch region; other site 373903000856 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903000857 FtsX-like permease family; Region: FtsX; cl15850 373903000858 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903000859 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 373903000860 FtsX-like permease family; Region: FtsX; cl15850 373903000861 Yip1 domain; Region: Yip1; cl12048 373903000862 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 373903000863 Domain of unknown function DUF; Region: DUF204; pfam02659 373903000864 Domain of unknown function DUF; Region: DUF204; pfam02659 373903000865 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 373903000866 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 373903000867 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 373903000868 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 373903000869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373903000870 active site 373903000871 catalytic tetrad [active] 373903000872 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373903000873 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903000874 putative peptidoglycan binding site; other site 373903000875 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 373903000876 active site 373903000877 catalytic residues [active] 373903000878 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 373903000879 Interdomain contacts; other site 373903000880 Cytokine receptor motif; other site 373903000881 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 373903000882 Ca binding site [ion binding]; other site 373903000883 ligand binding site I [chemical binding]; other site 373903000884 homodimer interface [polypeptide binding]; other site 373903000885 ligand binding site II [chemical binding]; other site 373903000886 manganese transport transcriptional regulator; Provisional; Region: PRK03902 373903000887 Helix-turn-helix domains; Region: HTH; cl00088 373903000888 Nucleoside recognition; Region: Gate; cl00486 373903000889 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 373903000890 Nucleoside recognition; Region: Gate; cl00486 373903000891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000892 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 373903000893 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 373903000894 G1 box; other site 373903000895 G1 box; other site 373903000896 GTP/Mg2+ binding site [chemical binding]; other site 373903000897 GTP/Mg2+ binding site [chemical binding]; other site 373903000898 Switch I region; other site 373903000899 G2 box; other site 373903000900 G3 box; other site 373903000901 Switch II region; other site 373903000902 G4 box; other site 373903000903 G5 box; other site 373903000904 FeoA domain; Region: FeoA; cl00838 373903000905 CAAX protease self-immunity; Region: Abi; cl00558 373903000906 OsmC-like protein; Region: OsmC; cl00767 373903000907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903000908 dimerization interface [polypeptide binding]; other site 373903000909 putative DNA binding site [nucleotide binding]; other site 373903000910 putative Zn2+ binding site [ion binding]; other site 373903000911 Predicted integral membrane protein [Function unknown]; Region: COG5658 373903000912 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 373903000913 SdpI/YhfL protein family; Region: SdpI; pfam13630 373903000914 CAAX protease self-immunity; Region: Abi; cl00558 373903000915 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 373903000916 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 373903000917 Walker A/P-loop; other site 373903000918 ATP binding site [chemical binding]; other site 373903000919 Q-loop/lid; other site 373903000920 ABC transporter signature motif; other site 373903000921 Walker B; other site 373903000922 D-loop; other site 373903000923 H-loop/switch region; other site 373903000924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 373903000925 Sterol carrier protein domain; Region: SCP2_2; pfam13530 373903000926 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 373903000927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903000928 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 373903000929 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 373903000930 heterotetramer interface [polypeptide binding]; other site 373903000931 active site pocket [active] 373903000932 cleavage site 373903000933 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 373903000934 feedback inhibition sensing region; other site 373903000935 homohexameric interface [polypeptide binding]; other site 373903000936 nucleotide binding site [chemical binding]; other site 373903000937 N-acetyl-L-glutamate binding site [chemical binding]; other site 373903000938 acetylornithine aminotransferase; Provisional; Region: PRK02627 373903000939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373903000940 inhibitor-cofactor binding pocket; inhibition site 373903000941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903000942 catalytic residue [active] 373903000943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903000944 Walker A/P-loop; other site 373903000945 ATP binding site [chemical binding]; other site 373903000946 Q-loop/lid; other site 373903000947 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 373903000948 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000949 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 373903000950 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 373903000951 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 373903000952 catalytic site [active] 373903000953 subunit interface [polypeptide binding]; other site 373903000954 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 373903000955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373903000956 ATP-grasp domain; Region: ATP-grasp_4; cl03087 373903000957 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 373903000958 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373903000959 ATP-grasp domain; Region: ATP-grasp_4; cl03087 373903000960 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 373903000961 substrate binding site [chemical binding]; other site 373903000962 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 373903000963 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 373903000964 ANP binding site [chemical binding]; other site 373903000965 Substrate Binding Site II [chemical binding]; other site 373903000966 Substrate Binding Site I [chemical binding]; other site 373903000967 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 373903000968 argininosuccinate lyase; Provisional; Region: PRK00855 373903000969 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 373903000970 active sites [active] 373903000971 tetramer interface [polypeptide binding]; other site 373903000972 Membrane transport protein; Region: Mem_trans; cl09117 373903000973 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 373903000974 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903000975 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 373903000976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903000977 PAS domain; Region: PAS_9; pfam13426 373903000978 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 373903000979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903000980 Walker A motif; other site 373903000981 ATP binding site [chemical binding]; other site 373903000982 Walker B motif; other site 373903000983 arginine finger; other site 373903000984 Helix-turn-helix domains; Region: HTH; cl00088 373903000985 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 373903000986 putative dimer interface [polypeptide binding]; other site 373903000987 [2Fe-2S] cluster binding site [ion binding]; other site 373903000988 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 373903000989 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 373903000990 SLBB domain; Region: SLBB; pfam10531 373903000991 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 373903000992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373903000993 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 373903000994 catalytic loop [active] 373903000995 iron binding site [ion binding]; other site 373903000996 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 373903000997 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903000998 4Fe-4S binding domain; Region: Fer4; cl02805 373903000999 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903001000 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 373903001001 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 373903001002 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 373903001003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001004 TRAM domain; Region: TRAM; cl01282 373903001005 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 373903001006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 373903001007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 373903001008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903001009 dimerization interface [polypeptide binding]; other site 373903001010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903001011 dimer interface [polypeptide binding]; other site 373903001012 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 373903001013 putative CheW interface [polypeptide binding]; other site 373903001014 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 373903001015 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 373903001016 Protein of unknown function (DUF523); Region: DUF523; cl00733 373903001017 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 373903001018 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903001019 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903001020 germination protein YpeB; Region: spore_YpeB; TIGR02889 373903001021 Uncharacterized conserved protein [Function unknown]; Region: COG2006 373903001022 Domain of unknown function (DUF362); Region: DUF362; pfam04015 373903001023 4Fe-4S binding domain; Region: Fer4; cl02805 373903001024 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 373903001025 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 373903001026 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 373903001027 active site 373903001028 metal binding site [ion binding]; metal-binding site 373903001029 homotetramer interface [polypeptide binding]; other site 373903001030 Protein of unknown function (DUF964); Region: DUF964; cl01483 373903001031 NifU-like domain; Region: NifU; cl00484 373903001032 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 373903001033 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 373903001034 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 373903001035 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 373903001036 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 373903001037 generic binding surface II; other site 373903001038 generic binding surface I; other site 373903001039 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 373903001040 Aspartase; Region: Aspartase; cd01357 373903001041 active sites [active] 373903001042 tetramer interface [polypeptide binding]; other site 373903001043 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 373903001044 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 373903001045 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 373903001046 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 373903001047 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 373903001048 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 373903001049 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 373903001050 active site 373903001051 ADP/pyrophosphate binding site [chemical binding]; other site 373903001052 dimerization interface [polypeptide binding]; other site 373903001053 allosteric effector site; other site 373903001054 fructose-1,6-bisphosphate binding site; other site 373903001055 pyruvate kinase; Provisional; Region: PRK06354 373903001056 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 373903001057 domain interfaces; other site 373903001058 active site 373903001059 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 373903001060 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373903001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903001062 DNA-binding site [nucleotide binding]; DNA binding site 373903001063 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 373903001064 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373903001065 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 373903001066 putative NAD(P) binding site [chemical binding]; other site 373903001067 catalytic Zn binding site [ion binding]; other site 373903001068 structural Zn binding site [ion binding]; other site 373903001069 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 373903001070 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 373903001071 DAK2 domain; Region: Dak2; cl03685 373903001072 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 373903001073 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 373903001074 active site 373903001075 intersubunit interactions; other site 373903001076 catalytic residue [active] 373903001077 transketolase; Reviewed; Region: PRK05899 373903001078 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 373903001079 TPP-binding site [chemical binding]; other site 373903001080 dimer interface [polypeptide binding]; other site 373903001081 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373903001082 PYR/PP interface [polypeptide binding]; other site 373903001083 dimer interface [polypeptide binding]; other site 373903001084 TPP binding site [chemical binding]; other site 373903001085 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373903001086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 373903001087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001088 dimer interface [polypeptide binding]; other site 373903001089 conserved gate region; other site 373903001090 putative PBP binding loops; other site 373903001091 ABC-ATPase subunit interface; other site 373903001092 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 373903001093 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 373903001094 Walker A/P-loop; other site 373903001095 ATP binding site [chemical binding]; other site 373903001096 Q-loop/lid; other site 373903001097 ABC transporter signature motif; other site 373903001098 Walker B; other site 373903001099 D-loop; other site 373903001100 H-loop/switch region; other site 373903001101 TOBE domain; Region: TOBE_2; cl01440 373903001102 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 373903001103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001104 Walker A/P-loop; other site 373903001105 ATP binding site [chemical binding]; other site 373903001106 Q-loop/lid; other site 373903001107 ABC transporter signature motif; other site 373903001108 Walker B; other site 373903001109 D-loop; other site 373903001110 H-loop/switch region; other site 373903001111 TOBE domain; Region: TOBE_2; cl01440 373903001112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903001113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903001114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903001115 dimerization interface [polypeptide binding]; other site 373903001116 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903001117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903001118 dimer interface [polypeptide binding]; other site 373903001119 putative CheW interface [polypeptide binding]; other site 373903001120 Domain of unknown function DUF77; Region: DUF77; cl00307 373903001121 S-layer homology domain; Region: SLH; pfam00395 373903001122 S-layer homology domain; Region: SLH; pfam00395 373903001123 S-layer homology domain; Region: SLH; pfam00395 373903001124 AAA domain; Region: AAA_32; pfam13654 373903001125 ATP-dependent protease Lon; Provisional; Region: PRK13765 373903001126 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903001127 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 373903001128 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 373903001129 putative DNA binding site [nucleotide binding]; other site 373903001130 putative homodimer interface [polypeptide binding]; other site 373903001131 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 373903001132 nucleotide binding site [chemical binding]; other site 373903001133 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 373903001134 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 373903001135 active site 373903001136 DNA binding site [nucleotide binding] 373903001137 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 373903001138 DNA binding site [nucleotide binding] 373903001139 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 373903001140 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 373903001141 active site 373903001142 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373903001143 CHC2 zinc finger; Region: zf-CHC2; cl15369 373903001144 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 373903001145 active site 373903001146 metal binding site [ion binding]; metal-binding site 373903001147 interdomain interaction site; other site 373903001148 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 373903001149 ERCC4 domain; Region: ERCC4; cl10594 373903001150 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 373903001151 oligomer interface [polypeptide binding]; other site 373903001152 active site residues [active] 373903001153 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 373903001154 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 373903001155 Int/Topo IB signature motif; other site 373903001156 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 373903001157 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 373903001158 GIY-YIG motif/motif A; other site 373903001159 putative active site [active] 373903001160 putative metal binding site [ion binding]; other site 373903001161 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 373903001162 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 373903001163 active site 373903001164 catalytic site [active] 373903001165 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 373903001166 Membrane transport protein; Region: Mem_trans; cl09117 373903001167 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 373903001168 ABC-2 type transporter; Region: ABC2_membrane; cl11417 373903001169 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373903001170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001171 Walker A/P-loop; other site 373903001172 ATP binding site [chemical binding]; other site 373903001173 Q-loop/lid; other site 373903001174 ABC transporter signature motif; other site 373903001175 Walker B; other site 373903001176 D-loop; other site 373903001177 H-loop/switch region; other site 373903001178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903001179 Helix-turn-helix domains; Region: HTH; cl00088 373903001180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903001181 Helix-turn-helix domains; Region: HTH; cl00088 373903001182 CcmE; Region: CcmE; cl00994 373903001183 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 373903001184 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 373903001185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001186 Walker A/P-loop; other site 373903001187 ATP binding site [chemical binding]; other site 373903001188 Q-loop/lid; other site 373903001189 ABC transporter signature motif; other site 373903001190 Walker B; other site 373903001191 D-loop; other site 373903001192 H-loop/switch region; other site 373903001193 CcmB protein; Region: CcmB; cl01016 373903001194 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 373903001195 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 373903001196 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 373903001197 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 373903001198 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 373903001199 nickel binding site [ion binding]; other site 373903001200 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 373903001201 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 373903001202 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 373903001203 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 373903001204 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 373903001205 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001206 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373903001207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001208 G4 box; other site 373903001209 G5 box; other site 373903001210 Acylphosphatase; Region: Acylphosphatase; cl00551 373903001211 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 373903001212 HypF finger; Region: zf-HYPF; pfam07503 373903001213 HypF finger; Region: zf-HYPF; pfam07503 373903001214 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 373903001215 HupF/HypC family; Region: HupF_HypC; cl00394 373903001216 Hydrogenase formation hypA family; Region: HypD; cl12072 373903001217 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 373903001218 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 373903001219 dimerization interface [polypeptide binding]; other site 373903001220 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 373903001221 ATP binding site [chemical binding]; other site 373903001222 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 373903001223 diiron binding motif [ion binding]; other site 373903001224 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 373903001225 GIY-YIG motif/motif A; other site 373903001226 putative active site [active] 373903001227 putative metal binding site [ion binding]; other site 373903001228 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 373903001229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373903001230 active site 373903001231 catalytic tetrad [active] 373903001232 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 373903001233 Uncharacterized conserved protein [Function unknown]; Region: COG1633 373903001234 dimanganese center [ion binding]; other site 373903001235 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 373903001236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903001237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903001238 DNA binding residues [nucleotide binding] 373903001239 Putative zinc-finger; Region: zf-HC2; cl15806 373903001240 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 373903001241 emp24/gp25L/p24 family/GOLD; Region: EMP24_GP25L; pfam01105 373903001242 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 373903001243 FMN-binding domain; Region: FMN_bind; cl01081 373903001244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373903001245 metal binding site [ion binding]; metal-binding site 373903001246 active site 373903001247 I-site; other site 373903001248 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 373903001249 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 373903001250 active site 373903001251 metal binding site [ion binding]; metal-binding site 373903001252 DNA binding site [nucleotide binding] 373903001253 exonuclease SbcC; Region: sbcc; TIGR00618 373903001254 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 373903001255 Walker A/P-loop; other site 373903001256 ATP binding site [chemical binding]; other site 373903001257 Q-loop/lid; other site 373903001258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001259 ABC transporter signature motif; other site 373903001260 Walker B; other site 373903001261 D-loop; other site 373903001262 H-loop/switch region; other site 373903001263 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373903001264 Helix-turn-helix domains; Region: HTH; cl00088 373903001265 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 373903001266 Cation efflux family; Region: Cation_efflux; cl00316 373903001267 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 373903001268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903001269 DNA-binding site [nucleotide binding]; DNA binding site 373903001270 UTRA domain; Region: UTRA; cl01230 373903001271 Chromate transporter; Region: Chromate_transp; pfam02417 373903001272 Chromate transporter; Region: Chromate_transp; pfam02417 373903001273 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 373903001274 dimer interface [polypeptide binding]; other site 373903001275 pyridoxal binding site [chemical binding]; other site 373903001276 ATP binding site [chemical binding]; other site 373903001277 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 373903001278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903001279 FeS/SAM binding site; other site 373903001280 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 373903001281 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 373903001282 putative recombination protein RecB; Provisional; Region: PRK13909 373903001283 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 373903001284 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 373903001285 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 373903001286 active site 373903001287 Zn binding site [ion binding]; other site 373903001288 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 373903001289 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 373903001290 Interdomain contacts; other site 373903001291 Cytokine receptor motif; other site 373903001292 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 373903001293 Interdomain contacts; other site 373903001294 Cytokine receptor motif; other site 373903001295 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 373903001296 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 373903001297 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 373903001298 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 373903001299 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 373903001300 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 373903001301 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 373903001302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903001303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903001304 DNA binding site [nucleotide binding] 373903001305 domain linker motif; other site 373903001306 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903001307 dimerization interface [polypeptide binding]; other site 373903001308 ligand binding site [chemical binding]; other site 373903001309 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 373903001310 active site 373903001311 catalytic residues [active] 373903001312 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903001313 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903001314 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903001315 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 373903001316 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 373903001317 active site 373903001318 catalytic residues [active] 373903001319 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 373903001320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903001321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903001322 DNA binding site [nucleotide binding] 373903001323 domain linker motif; other site 373903001324 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903001325 dimerization interface [polypeptide binding]; other site 373903001326 ligand binding site [chemical binding]; other site 373903001327 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 373903001328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903001329 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 373903001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001331 dimer interface [polypeptide binding]; other site 373903001332 conserved gate region; other site 373903001333 ABC-ATPase subunit interface; other site 373903001334 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903001335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001336 dimer interface [polypeptide binding]; other site 373903001337 conserved gate region; other site 373903001338 putative PBP binding loops; other site 373903001339 ABC-ATPase subunit interface; other site 373903001340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903001341 dimerization interface [polypeptide binding]; other site 373903001342 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903001343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903001344 dimer interface [polypeptide binding]; other site 373903001345 putative CheW interface [polypeptide binding]; other site 373903001346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903001347 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 373903001348 FeS/SAM binding site; other site 373903001349 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 373903001350 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 373903001351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 373903001352 FeS/SAM binding site; other site 373903001353 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 373903001354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001355 Walker A/P-loop; other site 373903001356 ATP binding site [chemical binding]; other site 373903001357 Q-loop/lid; other site 373903001358 ABC transporter signature motif; other site 373903001359 Walker B; other site 373903001360 D-loop; other site 373903001361 H-loop/switch region; other site 373903001362 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903001363 Helix-turn-helix domains; Region: HTH; cl00088 373903001364 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 373903001365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903001366 FeS/SAM binding site; other site 373903001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001368 HsdM N-terminal domain; Region: HsdM_N; pfam12161 373903001369 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 373903001370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001371 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373903001372 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373903001373 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373903001374 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 373903001375 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 373903001376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903001377 ATP binding site [chemical binding]; other site 373903001378 putative Mg++ binding site [ion binding]; other site 373903001379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001380 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 373903001381 Protein of unknown function DUF45; Region: DUF45; cl00636 373903001382 HTH-like domain; Region: HTH_21; pfam13276 373903001383 Integrase core domain; Region: rve; cl01316 373903001384 Helix-turn-helix domains; Region: HTH; cl00088 373903001385 Staphylococcal nuclease homologues; Region: SNc; smart00318 373903001386 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 373903001387 Catalytic site; other site 373903001388 Predicted transcriptional regulators [Transcription]; Region: COG1725 373903001389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903001390 DNA-binding site [nucleotide binding]; DNA binding site 373903001391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373903001392 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 373903001393 Walker A/P-loop; other site 373903001394 ATP binding site [chemical binding]; other site 373903001395 Q-loop/lid; other site 373903001396 ABC transporter signature motif; other site 373903001397 Walker B; other site 373903001398 D-loop; other site 373903001399 H-loop/switch region; other site 373903001400 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 373903001401 nucleotide binding site/active site [active] 373903001402 HIT family signature motif; other site 373903001403 catalytic residue [active] 373903001404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903001405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903001406 DNA binding site [nucleotide binding] 373903001407 domain linker motif; other site 373903001408 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903001409 dimerization interface [polypeptide binding]; other site 373903001410 ligand binding site [chemical binding]; other site 373903001411 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903001412 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 373903001413 substrate binding site [chemical binding]; other site 373903001414 dimer interface [polypeptide binding]; other site 373903001415 ATP binding site [chemical binding]; other site 373903001416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001417 dimer interface [polypeptide binding]; other site 373903001418 conserved gate region; other site 373903001419 putative PBP binding loops; other site 373903001420 ABC-ATPase subunit interface; other site 373903001421 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903001422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001423 dimer interface [polypeptide binding]; other site 373903001424 conserved gate region; other site 373903001425 putative PBP binding loops; other site 373903001426 ABC-ATPase subunit interface; other site 373903001427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903001428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903001429 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373903001430 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373903001431 Uncharacterized coiled-coil protein (DUF2353); Region: DUF2353; pfam09789 373903001432 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373903001433 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 373903001434 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 373903001435 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373903001436 active site 373903001437 nucleotide binding site [chemical binding]; other site 373903001438 HIGH motif; other site 373903001439 KMSKS motif; other site 373903001440 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 373903001441 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 373903001442 citrate lyase, alpha subunit; Region: citF; TIGR01584 373903001443 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 373903001444 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 373903001445 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 373903001446 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 373903001447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373903001448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903001449 active site 373903001450 phosphorylation site [posttranslational modification] 373903001451 intermolecular recognition site; other site 373903001452 dimerization interface [polypeptide binding]; other site 373903001453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373903001454 DNA binding site [nucleotide binding] 373903001455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373903001456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373903001457 dimer interface [polypeptide binding]; other site 373903001458 phosphorylation site [posttranslational modification] 373903001459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903001460 ATP binding site [chemical binding]; other site 373903001461 Mg2+ binding site [ion binding]; other site 373903001462 G-X-G motif; other site 373903001463 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373903001464 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 373903001465 Walker A/P-loop; other site 373903001466 ATP binding site [chemical binding]; other site 373903001467 Q-loop/lid; other site 373903001468 ABC transporter signature motif; other site 373903001469 Walker B; other site 373903001470 D-loop; other site 373903001471 H-loop/switch region; other site 373903001472 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 373903001473 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 373903001474 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 373903001475 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903001476 4Fe-4S binding domain; Region: Fer4; cl02805 373903001477 ferredoxin; Validated; Region: PRK07118 373903001478 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 373903001479 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373903001480 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 373903001481 OsmC-like protein; Region: OsmC; cl00767 373903001482 Cache domain; Region: Cache_1; pfam02743 373903001483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903001484 dimerization interface [polypeptide binding]; other site 373903001485 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903001486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903001487 dimer interface [polypeptide binding]; other site 373903001488 putative CheW interface [polypeptide binding]; other site 373903001489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903001490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373903001491 putative substrate translocation pore; other site 373903001492 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 373903001493 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 373903001494 MatE; Region: MatE; cl10513 373903001495 MatE; Region: MatE; cl10513 373903001496 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001497 putative peptidoglycan binding site; other site 373903001498 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001499 putative peptidoglycan binding site; other site 373903001500 Peptidase family M23; Region: Peptidase_M23; pfam01551 373903001501 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373903001502 metal-binding site [ion binding] 373903001503 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 373903001504 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373903001505 metal-binding site [ion binding] 373903001506 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373903001507 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903001508 DNA polymerase I; Provisional; Region: PRK05755 373903001509 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 373903001510 active site 373903001511 metal binding site 1 [ion binding]; metal-binding site 373903001512 putative 5' ssDNA interaction site; other site 373903001513 metal binding site 3; metal-binding site 373903001514 metal binding site 2 [ion binding]; metal-binding site 373903001515 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 373903001516 putative DNA binding site [nucleotide binding]; other site 373903001517 putative metal binding site [ion binding]; other site 373903001518 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 373903001519 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 373903001520 active site 373903001521 DNA binding site [nucleotide binding] 373903001522 catalytic site [active] 373903001523 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 373903001524 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 373903001525 DNA binding site [nucleotide binding] 373903001526 catalytic residue [active] 373903001527 H2TH interface [polypeptide binding]; other site 373903001528 putative catalytic residues [active] 373903001529 turnover-facilitating residue; other site 373903001530 intercalation triad [nucleotide binding]; other site 373903001531 8OG recognition residue [nucleotide binding]; other site 373903001532 putative reading head residues; other site 373903001533 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 373903001534 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373903001535 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 373903001536 Domain of unknown function DUF; Region: DUF204; pfam02659 373903001537 dephospho-CoA kinase; Region: TIGR00152 373903001538 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 373903001539 CoA-binding site [chemical binding]; other site 373903001540 ATP-binding [chemical binding]; other site 373903001541 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 373903001542 active site 373903001543 dimer interfaces [polypeptide binding]; other site 373903001544 catalytic residues [active] 373903001545 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373903001546 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 373903001547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001548 dimer interface [polypeptide binding]; other site 373903001549 conserved gate region; other site 373903001550 putative PBP binding loops; other site 373903001551 ABC-ATPase subunit interface; other site 373903001552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903001553 dimer interface [polypeptide binding]; other site 373903001554 conserved gate region; other site 373903001555 putative PBP binding loops; other site 373903001556 ABC-ATPase subunit interface; other site 373903001557 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 373903001558 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 373903001559 Walker A/P-loop; other site 373903001560 ATP binding site [chemical binding]; other site 373903001561 Q-loop/lid; other site 373903001562 ABC transporter signature motif; other site 373903001563 Walker B; other site 373903001564 D-loop; other site 373903001565 H-loop/switch region; other site 373903001566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373903001567 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 373903001568 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 373903001569 Walker A/P-loop; other site 373903001570 ATP binding site [chemical binding]; other site 373903001571 Q-loop/lid; other site 373903001572 ABC transporter signature motif; other site 373903001573 Walker B; other site 373903001574 D-loop; other site 373903001575 H-loop/switch region; other site 373903001576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373903001577 UTRA domain; Region: UTRA; cl01230 373903001578 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 373903001579 Protein of unknown function (DUF523); Region: DUF523; cl00733 373903001580 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 373903001581 photolyase PhrII; Region: phr2; TIGR00591 373903001582 DNA photolyase; Region: DNA_photolyase; pfam00875 373903001583 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 373903001584 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 373903001585 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 373903001586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903001587 FeS/SAM binding site; other site 373903001588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903001589 Helix-turn-helix domains; Region: HTH; cl00088 373903001590 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 373903001591 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 373903001592 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373903001593 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 373903001594 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 373903001595 FeoA domain; Region: FeoA; cl00838 373903001596 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 373903001597 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 373903001598 G1 box; other site 373903001599 GTP/Mg2+ binding site [chemical binding]; other site 373903001600 Switch I region; other site 373903001601 G2 box; other site 373903001602 G3 box; other site 373903001603 Switch II region; other site 373903001604 G4 box; other site 373903001605 G5 box; other site 373903001606 Nucleoside recognition; Region: Gate; cl00486 373903001607 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 373903001608 Nucleoside recognition; Region: Gate; cl00486 373903001609 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 373903001610 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 373903001611 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 373903001612 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 373903001613 dinuclear metal binding motif [ion binding]; other site 373903001614 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 373903001615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903001616 active site 373903001617 motif I; other site 373903001618 motif II; other site 373903001619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001620 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 373903001621 Spore germination protein; Region: Spore_permease; cl15802 373903001622 Uncharacterized membrane protein [Function unknown]; Region: COG3949 373903001623 Bacterial SH3 domain; Region: SH3_3; cl02551 373903001624 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373903001625 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 373903001626 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903001627 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903001628 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 373903001629 active site 373903001630 catalytic triad [active] 373903001631 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 373903001632 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 373903001633 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 373903001634 MatE; Region: MatE; cl10513 373903001635 MatE; Region: MatE; cl10513 373903001636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903001637 S-adenosylmethionine binding site [chemical binding]; other site 373903001638 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 373903001639 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 373903001640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373903001641 metal binding site [ion binding]; metal-binding site 373903001642 active site 373903001643 I-site; other site 373903001644 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 373903001645 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903001646 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373903001647 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 373903001648 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 373903001649 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 373903001650 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 373903001651 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373903001652 dimer interface [polypeptide binding]; other site 373903001653 PYR/PP interface [polypeptide binding]; other site 373903001654 TPP binding site [chemical binding]; other site 373903001655 substrate binding site [chemical binding]; other site 373903001656 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 373903001657 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 373903001658 TPP-binding site [chemical binding]; other site 373903001659 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 373903001660 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 373903001661 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 373903001662 non-heme iron binding site [ion binding]; other site 373903001663 dimer interface [polypeptide binding]; other site 373903001664 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 373903001665 non-heme iron binding site [ion binding]; other site 373903001666 potential frameshift: common BLAST hit: gi|212640025|ref|YP_002316545.1| Phytoene dehydrogenase (Phytoene desaturase) 373903001667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001668 phytoene desaturase; Region: crtI_fam; TIGR02734 373903001669 phytoene desaturase; Region: crtI_fam; TIGR02734 373903001670 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 373903001671 Protein of unknown function (DUF421); Region: DUF421; cl00990 373903001672 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 373903001673 Protein export membrane protein; Region: SecD_SecF; cl14618 373903001674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903001675 Helix-turn-helix domains; Region: HTH; cl00088 373903001676 Coat F domain; Region: Coat_F; cl15836 373903001677 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 373903001678 DNA-binding site [nucleotide binding]; DNA binding site 373903001679 RNA-binding motif; other site 373903001680 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 373903001681 Sodium:solute symporter family; Region: SSF; cl00456 373903001682 Protein of unknown function (DUF421); Region: DUF421; cl00990 373903001683 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 373903001684 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 373903001685 active site 373903001686 HIGH motif; other site 373903001687 KMSKS motif; other site 373903001688 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 373903001689 tRNA binding surface [nucleotide binding]; other site 373903001690 anticodon binding site; other site 373903001691 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 373903001692 Helix-turn-helix domains; Region: HTH; cl00088 373903001693 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 373903001694 putative dimerization interface [polypeptide binding]; other site 373903001695 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 373903001696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903001697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373903001698 putative substrate translocation pore; other site 373903001699 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 373903001700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373903001701 ATP binding site [chemical binding]; other site 373903001702 Mg++ binding site [ion binding]; other site 373903001703 motif III; other site 373903001704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903001705 nucleotide binding region [chemical binding]; other site 373903001706 ATP-binding site [chemical binding]; other site 373903001707 DbpA RNA binding domain; Region: DbpA; pfam03880 373903001708 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 373903001709 DNA-binding site [nucleotide binding]; DNA binding site 373903001710 RNA-binding motif; other site 373903001711 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373903001712 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373903001713 DNA binding residues [nucleotide binding] 373903001714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903001715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903001716 H+ Antiporter protein; Region: 2A0121; TIGR00900 373903001717 putative substrate translocation pore; other site 373903001718 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 373903001719 active site 373903001720 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 373903001721 YtxC-like family; Region: YtxC; cl08500 373903001722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 373903001723 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 373903001724 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 373903001725 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 373903001726 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 373903001727 active site 373903001728 dimer interface [polypeptide binding]; other site 373903001729 motif 1; other site 373903001730 motif 2; other site 373903001731 motif 3; other site 373903001732 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 373903001733 anticodon binding site; other site 373903001734 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 373903001735 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 373903001736 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 373903001737 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 373903001738 23S rRNA binding site [nucleotide binding]; other site 373903001739 L21 binding site [polypeptide binding]; other site 373903001740 L13 binding site [polypeptide binding]; other site 373903001741 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 373903001742 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 373903001743 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 373903001744 T-box leader 373903001745 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 373903001746 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 373903001747 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 373903001748 dimer interface [polypeptide binding]; other site 373903001749 motif 1; other site 373903001750 active site 373903001751 motif 2; other site 373903001752 motif 3; other site 373903001753 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 373903001754 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 373903001755 putative tRNA-binding site [nucleotide binding]; other site 373903001756 B3/4 domain; Region: B3_4; cl11458 373903001757 tRNA synthetase B5 domain; Region: B5; cl08394 373903001758 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 373903001759 dimer interface [polypeptide binding]; other site 373903001760 motif 1; other site 373903001761 motif 3; other site 373903001762 motif 2; other site 373903001763 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 373903001764 Cell division protein ZapA; Region: ZapA; cl01146 373903001765 Colicin V production protein; Region: Colicin_V; cl00567 373903001766 hypothetical protein; Provisional; Region: PRK08609 373903001767 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 373903001768 active site 373903001769 primer binding site [nucleotide binding]; other site 373903001770 NTP binding site [chemical binding]; other site 373903001771 metal binding triad [ion binding]; metal-binding site 373903001772 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 373903001773 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 373903001774 Walker A/P-loop; other site 373903001775 ATP binding site [chemical binding]; other site 373903001776 Q-loop/lid; other site 373903001777 ABC transporter signature motif; other site 373903001778 Walker B; other site 373903001779 D-loop; other site 373903001780 H-loop/switch region; other site 373903001781 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 373903001782 Smr domain; Region: Smr; cl02619 373903001783 Transglycosylase; Region: Transgly; cl07896 373903001784 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 373903001785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903001786 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 373903001787 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 373903001788 active site 373903001789 HIGH motif; other site 373903001790 dimer interface [polypeptide binding]; other site 373903001791 KMSKS motif; other site 373903001792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 373903001793 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 373903001794 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 373903001795 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 373903001796 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 373903001797 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373903001798 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 373903001799 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 373903001800 motif 1; other site 373903001801 active site 373903001802 motif 2; other site 373903001803 motif 3; other site 373903001804 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 373903001805 DHHA1 domain; Region: DHHA1; pfam02272 373903001806 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 373903001807 Cell division protein FtsA; Region: FtsA; cl11496 373903001808 Cell division protein FtsA; Region: FtsA; cl11496 373903001809 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 373903001810 YceG-like family; Region: YceG; pfam02618 373903001811 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 373903001812 dimerization interface [polypeptide binding]; other site 373903001813 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 373903001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903001815 S-adenosylmethionine binding site [chemical binding]; other site 373903001816 putative protease; Provisional; Region: PRK15452 373903001817 Peptidase family U32; Region: Peptidase_U32; cl03113 373903001818 sporulation sigma factor SigK; Reviewed; Region: PRK05803 373903001819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903001820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903001821 DNA binding residues [nucleotide binding] 373903001822 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 373903001823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903001824 motif II; other site 373903001825 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 373903001826 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903001827 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903001828 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 373903001829 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373903001830 metal binding site 2 [ion binding]; metal-binding site 373903001831 putative DNA binding helix; other site 373903001832 metal binding site 1 [ion binding]; metal-binding site 373903001833 dimer interface [polypeptide binding]; other site 373903001834 structural Zn2+ binding site [ion binding]; other site 373903001835 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 373903001836 G1 box; other site 373903001837 GTP/Mg2+ binding site [chemical binding]; other site 373903001838 Switch I region; other site 373903001839 G2 box; other site 373903001840 G3 box; other site 373903001841 Switch II region; other site 373903001842 G4 box; other site 373903001843 G5 box; other site 373903001844 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 373903001845 Nucleoside recognition; Region: Gate; cl00486 373903001846 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 373903001847 Nucleoside recognition; Region: Gate; cl00486 373903001848 FeoA domain; Region: FeoA; cl00838 373903001849 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373903001850 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373903001851 ligand binding site [chemical binding]; other site 373903001852 flexible hinge region; other site 373903001853 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373903001854 putative switch regulator; other site 373903001855 non-specific DNA interactions [nucleotide binding]; other site 373903001856 DNA binding site [nucleotide binding] 373903001857 sequence specific DNA binding site [nucleotide binding]; other site 373903001858 putative cAMP binding site [chemical binding]; other site 373903001859 EamA-like transporter family; Region: EamA; cl01037 373903001860 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 373903001861 EamA-like transporter family; Region: EamA; cl01037 373903001862 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 373903001863 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 373903001864 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 373903001865 shikimate binding site; other site 373903001866 NAD(P) binding site [chemical binding]; other site 373903001867 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 373903001868 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 373903001869 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 373903001870 Walker A motif; other site 373903001871 ATP binding site [chemical binding]; other site 373903001872 Walker B motif; other site 373903001873 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 373903001874 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 373903001875 Walker A motif; other site 373903001876 ATP binding site [chemical binding]; other site 373903001877 Walker B motif; other site 373903001878 general secretion pathway protein F; Region: GspF; TIGR02120 373903001879 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 373903001880 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 373903001881 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 373903001882 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 373903001883 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 373903001884 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 373903001885 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 373903001886 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 373903001887 Cell division protein FtsA; Region: FtsA; cl11496 373903001888 Competence protein A; Region: Competence_A; pfam11104 373903001889 Cell division protein FtsA; Region: FtsA; cl11496 373903001890 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 373903001891 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 373903001892 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 373903001893 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 373903001894 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 373903001895 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 373903001896 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 373903001897 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001898 putative peptidoglycan binding site; other site 373903001899 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001900 putative peptidoglycan binding site; other site 373903001901 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 373903001902 Tetramer interface [polypeptide binding]; other site 373903001903 active site 373903001904 FMN-binding site [chemical binding]; other site 373903001905 shikimate kinase; Reviewed; Region: aroK; PRK00131 373903001906 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 373903001907 ADP binding site [chemical binding]; other site 373903001908 magnesium binding site [ion binding]; other site 373903001909 putative shikimate binding site; other site 373903001910 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 373903001911 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 373903001912 active site 373903001913 dimer interface [polypeptide binding]; other site 373903001914 metal binding site [ion binding]; metal-binding site 373903001915 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 373903001916 trimer interface [polypeptide binding]; other site 373903001917 active site 373903001918 dimer interface [polypeptide binding]; other site 373903001919 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 373903001920 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 373903001921 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 373903001922 active site 373903001923 elongation factor P; Validated; Region: PRK00529 373903001924 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 373903001925 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 373903001926 RNA binding site [nucleotide binding]; other site 373903001927 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 373903001928 RNA binding site [nucleotide binding]; other site 373903001929 Sugar fermentation stimulation protein; Region: SfsA; cl00647 373903001930 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 373903001931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001932 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 373903001933 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 373903001934 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 373903001935 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 373903001936 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 373903001937 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 373903001938 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 373903001939 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 373903001940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 373903001941 carboxyltransferase (CT) interaction site; other site 373903001942 biotinylation site [posttranslational modification]; other site 373903001943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 373903001944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373903001945 ATP-grasp domain; Region: ATP-grasp_4; cl03087 373903001946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 373903001947 Asp23 family; Region: Asp23; cl00574 373903001948 Asp23 family; Region: Asp23; cl00574 373903001949 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 373903001950 putative RNA binding site [nucleotide binding]; other site 373903001951 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 373903001952 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 373903001953 putative dimer interface [polypeptide binding]; other site 373903001954 [2Fe-2S] cluster binding site [ion binding]; other site 373903001955 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 373903001956 dimer interface [polypeptide binding]; other site 373903001957 [2Fe-2S] cluster binding site [ion binding]; other site 373903001958 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 373903001959 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 373903001960 SLBB domain; Region: SLBB; pfam10531 373903001961 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 373903001962 4Fe-4S binding domain; Region: Fer4; cl02805 373903001963 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 373903001964 4Fe-4S binding domain; Region: Fer4; cl02805 373903001965 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373903001966 catalytic loop [active] 373903001967 iron binding site [ion binding]; other site 373903001968 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 373903001969 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 373903001970 4Fe-4S binding domain; Region: Fer4; cl02805 373903001971 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 373903001972 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 373903001973 FOG: CBS domain [General function prediction only]; Region: COG0517 373903001974 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 373903001975 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 373903001976 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 373903001977 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 373903001978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373903001979 active site 373903001980 metal binding site [ion binding]; metal-binding site 373903001981 DNA binding site [nucleotide binding] 373903001982 Uncharacterized conserved protein [Function unknown]; Region: COG4717 373903001983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903001984 Walker A/P-loop; other site 373903001985 ATP binding site [chemical binding]; other site 373903001986 AAA domain; Region: AAA_27; pfam13514 373903001987 COG4 transport protein; Region: COG4; cl07072 373903001988 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 373903001989 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001990 putative peptidoglycan binding site; other site 373903001991 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001992 putative peptidoglycan binding site; other site 373903001993 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001994 putative peptidoglycan binding site; other site 373903001995 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 373903001996 active site 373903001997 catalytic triad [active] 373903001998 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903001999 putative peptidoglycan binding site; other site 373903002000 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002001 putative peptidoglycan binding site; other site 373903002002 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002003 putative peptidoglycan binding site; other site 373903002004 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002005 putative peptidoglycan binding site; other site 373903002006 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002007 putative peptidoglycan binding site; other site 373903002008 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002009 putative peptidoglycan binding site; other site 373903002010 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903002011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 373903002012 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903002013 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 373903002014 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 373903002015 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002016 putative peptidoglycan binding site; other site 373903002017 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903002018 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002019 putative peptidoglycan binding site; other site 373903002020 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002021 putative peptidoglycan binding site; other site 373903002022 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 373903002023 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 373903002024 NodB motif; other site 373903002025 active site 373903002026 catalytic site [active] 373903002027 metal binding site [ion binding]; metal-binding site 373903002028 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 373903002029 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 373903002030 FAD binding pocket [chemical binding]; other site 373903002031 FAD binding motif [chemical binding]; other site 373903002032 phosphate binding motif [ion binding]; other site 373903002033 beta-alpha-beta structure motif; other site 373903002034 NAD binding pocket [chemical binding]; other site 373903002035 Iron coordination center [ion binding]; other site 373903002036 putative oxidoreductase; Provisional; Region: PRK12831 373903002037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002039 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 373903002040 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 373903002041 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 373903002042 homodimer interface [polypeptide binding]; other site 373903002043 NADP binding site [chemical binding]; other site 373903002044 substrate binding site [chemical binding]; other site 373903002045 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 373903002046 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 373903002047 generic binding surface II; other site 373903002048 generic binding surface I; other site 373903002049 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 373903002050 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 373903002051 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373903002052 substrate binding pocket [chemical binding]; other site 373903002053 chain length determination region; other site 373903002054 substrate-Mg2+ binding site; other site 373903002055 catalytic residues [active] 373903002056 aspartate-rich region 1; other site 373903002057 active site lid residues [active] 373903002058 aspartate-rich region 2; other site 373903002059 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 373903002060 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 373903002061 TPP-binding site; other site 373903002062 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373903002063 PYR/PP interface [polypeptide binding]; other site 373903002064 dimer interface [polypeptide binding]; other site 373903002065 TPP binding site [chemical binding]; other site 373903002066 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373903002067 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 373903002068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373903002069 RNA binding surface [nucleotide binding]; other site 373903002070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 373903002071 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 373903002072 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 373903002073 arginine repressor; Provisional; Region: PRK04280 373903002074 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 373903002075 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 373903002076 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 373903002077 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 373903002078 Walker A/P-loop; other site 373903002079 ATP binding site [chemical binding]; other site 373903002080 Q-loop/lid; other site 373903002081 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 373903002082 ABC transporter signature motif; other site 373903002083 Walker B; other site 373903002084 D-loop; other site 373903002085 H-loop/switch region; other site 373903002086 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 373903002087 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 373903002088 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 373903002089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903002090 active site 373903002091 phosphorylation site [posttranslational modification] 373903002092 intermolecular recognition site; other site 373903002093 dimerization interface [polypeptide binding]; other site 373903002094 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 373903002095 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 373903002096 Thiamine pyrophosphokinase; Region: TPK; cl08415 373903002097 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 373903002098 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 373903002099 Ligand binding site; other site 373903002100 Putative Catalytic site; other site 373903002101 DXD motif; other site 373903002102 Helix-turn-helix domains; Region: HTH; cl00088 373903002103 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 373903002104 C-terminal domain interface [polypeptide binding]; other site 373903002105 sugar binding site [chemical binding]; other site 373903002106 Amidinotransferase; Region: Amidinotransf; cl12043 373903002107 ornithine carbamoyltransferase; Validated; Region: PRK02102 373903002108 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373903002109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002110 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 373903002111 carbamate kinase; Reviewed; Region: PRK12686 373903002112 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 373903002113 putative substrate binding site [chemical binding]; other site 373903002114 nucleotide binding site [chemical binding]; other site 373903002115 nucleotide binding site [chemical binding]; other site 373903002116 homodimer interface [polypeptide binding]; other site 373903002117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903002118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903002119 dimer interface [polypeptide binding]; other site 373903002120 putative CheW interface [polypeptide binding]; other site 373903002121 Cache domain; Region: Cache_1; pfam02743 373903002122 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 373903002123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903002124 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 373903002125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903002126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903002127 Walker A motif; other site 373903002128 ATP binding site [chemical binding]; other site 373903002129 Walker B motif; other site 373903002130 arginine finger; other site 373903002131 Helix-turn-helix domains; Region: HTH; cl00088 373903002132 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 373903002133 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373903002134 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 373903002135 NAD binding site [chemical binding]; other site 373903002136 Phe binding site; other site 373903002137 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 373903002138 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 373903002139 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 373903002140 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373903002141 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 373903002142 NAD binding site [chemical binding]; other site 373903002143 Phe binding site; other site 373903002144 Acetokinase family; Region: Acetate_kinase; cl01029 373903002145 hypothetical protein; Provisional; Region: PRK13795 373903002146 4Fe-4S binding domain; Region: Fer4; cl02805 373903002147 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 373903002148 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373903002149 dimer interface [polypeptide binding]; other site 373903002150 PYR/PP interface [polypeptide binding]; other site 373903002151 TPP binding site [chemical binding]; other site 373903002152 substrate binding site [chemical binding]; other site 373903002153 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373903002154 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 373903002155 TPP-binding site [chemical binding]; other site 373903002156 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 373903002157 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 373903002158 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 373903002159 peptidase T-like protein; Region: PepT-like; TIGR01883 373903002160 metal binding site [ion binding]; metal-binding site 373903002161 putative dimer interface [polypeptide binding]; other site 373903002162 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 373903002163 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373903002164 dimer interface [polypeptide binding]; other site 373903002165 ADP-ribose binding site [chemical binding]; other site 373903002166 active site 373903002167 nudix motif; other site 373903002168 metal binding site [ion binding]; metal-binding site 373903002169 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 373903002170 PHP-associated; Region: PHP_C; pfam13263 373903002171 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 373903002172 DNA binding site [nucleotide binding] 373903002173 Integral membrane protein DUF95; Region: DUF95; cl00572 373903002174 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 373903002175 Helix-turn-helix domains; Region: HTH; cl00088 373903002176 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 373903002177 glycogen synthase; Provisional; Region: glgA; PRK00654 373903002178 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 373903002179 ADP-binding pocket [chemical binding]; other site 373903002180 homodimer interface [polypeptide binding]; other site 373903002181 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 373903002182 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 373903002183 ligand binding site; other site 373903002184 oligomer interface; other site 373903002185 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 373903002186 dimer interface [polypeptide binding]; other site 373903002187 N-terminal domain interface [polypeptide binding]; other site 373903002188 sulfate 1 binding site; other site 373903002189 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 373903002190 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 373903002191 ligand binding site; other site 373903002192 oligomer interface; other site 373903002193 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 373903002194 dimer interface [polypeptide binding]; other site 373903002195 N-terminal domain interface [polypeptide binding]; other site 373903002196 sulfate 1 binding site; other site 373903002197 glycogen branching enzyme; Provisional; Region: PRK12313 373903002198 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 373903002199 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 373903002200 active site 373903002201 catalytic site [active] 373903002202 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 373903002203 glycogen synthase; Provisional; Region: glgA; PRK00654 373903002204 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 373903002205 ADP-binding pocket [chemical binding]; other site 373903002206 homodimer interface [polypeptide binding]; other site 373903002207 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 373903002208 Sulfatase; Region: Sulfatase; cl10460 373903002209 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 373903002210 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 373903002211 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373903002212 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373903002213 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 373903002214 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 373903002215 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903002216 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 373903002217 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 373903002218 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 373903002219 active site 373903002220 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373903002221 anti sigma factor interaction site; other site 373903002222 regulatory phosphorylation site [posttranslational modification]; other site 373903002223 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 373903002224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903002225 ATP binding site [chemical binding]; other site 373903002226 Mg2+ binding site [ion binding]; other site 373903002227 G-X-G motif; other site 373903002228 sporulation sigma factor SigF; Validated; Region: PRK05572 373903002229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903002230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903002231 DNA binding residues [nucleotide binding] 373903002232 Dodecin; Region: Dodecin; cl01328 373903002233 SpoVA protein; Region: SpoVA; cl04298 373903002234 stage V sporulation protein AD; Validated; Region: PRK08304 373903002235 stage V sporulation protein AD; Provisional; Region: PRK12404 373903002236 SpoVA protein; Region: SpoVA; cl04298 373903002237 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 373903002238 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 373903002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 373903002240 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 373903002241 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903002242 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002243 diaminopimelate decarboxylase; Region: lysA; TIGR01048 373903002244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 373903002245 active site 373903002246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373903002247 substrate binding site [chemical binding]; other site 373903002248 catalytic residues [active] 373903002249 dimer interface [polypeptide binding]; other site 373903002250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 373903002251 DHH family; Region: DHH; pfam01368 373903002252 FOG: CBS domain [General function prediction only]; Region: COG0517 373903002253 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 373903002254 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373903002255 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 373903002256 active site 373903002257 NTP binding site [chemical binding]; other site 373903002258 metal binding triad [ion binding]; metal-binding site 373903002259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903002260 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 373903002261 active site 373903002262 putative substrate binding region [chemical binding]; other site 373903002263 ScpA/B protein; Region: ScpA_ScpB; cl00598 373903002264 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 373903002265 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 373903002266 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 373903002267 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 373903002268 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 373903002269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903002270 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 373903002271 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 373903002272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373903002273 RNA binding surface [nucleotide binding]; other site 373903002274 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 373903002275 active site 373903002276 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 373903002277 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 373903002278 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 373903002279 Walker A/P-loop; other site 373903002280 ATP binding site [chemical binding]; other site 373903002281 Q-loop/lid; other site 373903002282 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 373903002283 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 373903002284 ABC transporter signature motif; other site 373903002285 Walker B; other site 373903002286 D-loop; other site 373903002287 H-loop/switch region; other site 373903002288 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 373903002289 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 373903002290 P loop; other site 373903002291 GTP binding site [chemical binding]; other site 373903002292 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 373903002293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903002294 DNA binding residues [nucleotide binding] 373903002295 signal recognition particle protein; Provisional; Region: PRK10867 373903002296 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 373903002297 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 373903002298 P loop; other site 373903002299 GTP binding site [chemical binding]; other site 373903002300 Signal peptide binding domain; Region: SRP_SPB; pfam02978 373903002301 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 373903002302 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 373903002303 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 373903002304 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 373903002305 RimM N-terminal domain; Region: RimM; pfam01782 373903002306 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 373903002307 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 373903002308 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 373903002309 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 373903002310 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 373903002311 GTP/Mg2+ binding site [chemical binding]; other site 373903002312 G4 box; other site 373903002313 G5 box; other site 373903002314 G1 box; other site 373903002315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002316 Switch I region; other site 373903002317 G2 box; other site 373903002318 G3 box; other site 373903002319 Switch II region; other site 373903002320 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 373903002321 RNA/DNA hybrid binding site [nucleotide binding]; other site 373903002322 active site 373903002323 QueT transporter; Region: QueT; cl01932 373903002324 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 373903002325 Restriction endonuclease; Region: Mrr_cat; cl00516 373903002326 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 373903002327 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903002328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903002329 Walker A motif; other site 373903002330 ATP binding site [chemical binding]; other site 373903002331 Walker B motif; other site 373903002332 arginine finger; other site 373903002333 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 373903002334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373903002335 PAS domain; Region: PAS_9; pfam13426 373903002336 putative active site [active] 373903002337 heme pocket [chemical binding]; other site 373903002338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373903002339 dimer interface [polypeptide binding]; other site 373903002340 phosphorylation site [posttranslational modification] 373903002341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903002342 ATP binding site [chemical binding]; other site 373903002343 Mg2+ binding site [ion binding]; other site 373903002344 G-X-G motif; other site 373903002345 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 373903002346 ZIP Zinc transporter; Region: Zip; pfam02535 373903002347 HEAT repeats; Region: HEAT_2; pfam13646 373903002348 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 373903002349 active site 373903002350 catalytic triad [active] 373903002351 dimer interface [polypeptide binding]; other site 373903002352 Predicted amidohydrolase [General function prediction only]; Region: COG0388 373903002353 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 373903002354 putative active site [active] 373903002355 catalytic triad [active] 373903002356 putative dimer interface [polypeptide binding]; other site 373903002357 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 373903002358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373903002359 sequence-specific DNA binding site [nucleotide binding]; other site 373903002360 salt bridge; other site 373903002361 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 373903002362 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373903002363 B12 binding site [chemical binding]; other site 373903002364 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 373903002365 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 373903002366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373903002367 active site 373903002368 catalytic tetrad [active] 373903002369 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373903002370 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 373903002371 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 373903002372 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 373903002373 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 373903002374 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 373903002375 DNA topoisomerase I; Validated; Region: PRK05582 373903002376 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 373903002377 active site 373903002378 interdomain interaction site; other site 373903002379 putative metal-binding site [ion binding]; other site 373903002380 nucleotide binding site [chemical binding]; other site 373903002381 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 373903002382 domain I; other site 373903002383 DNA binding groove [nucleotide binding] 373903002384 phosphate binding site [ion binding]; other site 373903002385 domain II; other site 373903002386 domain III; other site 373903002387 nucleotide binding site [chemical binding]; other site 373903002388 catalytic site [active] 373903002389 domain IV; other site 373903002390 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 373903002391 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 373903002392 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 373903002393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002394 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 373903002395 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 373903002396 active site 373903002397 HslU subunit interaction site [polypeptide binding]; other site 373903002398 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 373903002399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903002400 Walker A motif; other site 373903002401 ATP binding site [chemical binding]; other site 373903002402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002403 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 373903002404 transcriptional repressor CodY; Validated; Region: PRK04158 373903002405 CodY GAF-like domain; Region: CodY; pfam06018 373903002406 Helix-turn-helix domains; Region: HTH; cl00088 373903002407 Response regulator receiver domain; Region: Response_reg; pfam00072 373903002408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903002409 active site 373903002410 phosphorylation site [posttranslational modification] 373903002411 intermolecular recognition site; other site 373903002412 dimerization interface [polypeptide binding]; other site 373903002413 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373903002414 putative binding surface; other site 373903002415 active site 373903002416 P2 response regulator binding domain; Region: P2; pfam07194 373903002417 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373903002418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903002419 ATP binding site [chemical binding]; other site 373903002420 Mg2+ binding site [ion binding]; other site 373903002421 G-X-G motif; other site 373903002422 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 373903002423 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 373903002424 putative CheA interaction surface; other site 373903002425 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 373903002426 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 373903002427 Chemotaxis phosphatase CheX; Region: CheX; cl15816 373903002428 Chemotaxis phosphatase CheX; Region: CheX; cl15816 373903002429 CheD chemotactic sensory transduction; Region: CheD; cl00810 373903002430 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 373903002431 rRNA interaction site [nucleotide binding]; other site 373903002432 S8 interaction site; other site 373903002433 putative laminin-1 binding site; other site 373903002434 elongation factor Ts; Provisional; Region: tsf; PRK09377 373903002435 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 373903002436 Elongation factor TS; Region: EF_TS; pfam00889 373903002437 Elongation factor TS; Region: EF_TS; pfam00889 373903002438 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 373903002439 putative nucleotide binding site [chemical binding]; other site 373903002440 uridine monophosphate binding site [chemical binding]; other site 373903002441 homohexameric interface [polypeptide binding]; other site 373903002442 ribosome recycling factor; Reviewed; Region: frr; PRK00083 373903002443 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 373903002444 hinge region; other site 373903002445 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 373903002446 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 373903002447 catalytic residue [active] 373903002448 putative FPP diphosphate binding site; other site 373903002449 putative FPP binding hydrophobic cleft; other site 373903002450 dimer interface [polypeptide binding]; other site 373903002451 putative IPP diphosphate binding site; other site 373903002452 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 373903002453 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 373903002454 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373903002455 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 373903002456 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 373903002457 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 373903002458 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 373903002459 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 373903002460 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 373903002461 active site 373903002462 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 373903002463 protein binding site [polypeptide binding]; other site 373903002464 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 373903002465 putative substrate binding region [chemical binding]; other site 373903002466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903002467 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373903002468 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373903002469 prolyl-tRNA synthetase; Provisional; Region: PRK09194 373903002470 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 373903002471 dimer interface [polypeptide binding]; other site 373903002472 motif 1; other site 373903002473 active site 373903002474 motif 2; other site 373903002475 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 373903002476 putative deacylase active site [active] 373903002477 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 373903002478 active site 373903002479 motif 3; other site 373903002480 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 373903002481 anticodon binding site; other site 373903002482 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 373903002483 Ligand binding site; other site 373903002484 DXD motif; other site 373903002485 Putative Catalytic site; other site 373903002486 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 373903002487 MgtC family; Region: MgtC; pfam02308 373903002488 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 373903002489 DNA polymerase III PolC; Validated; Region: polC; PRK00448 373903002490 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 373903002491 generic binding surface II; other site 373903002492 generic binding surface I; other site 373903002493 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 373903002494 active site 373903002495 substrate binding site [chemical binding]; other site 373903002496 catalytic site [active] 373903002497 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 373903002498 ribosome maturation protein RimP; Reviewed; Region: PRK00092 373903002499 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 373903002500 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 373903002501 Sm1 motif; other site 373903002502 predicted subunit interaction site [polypeptide binding]; other site 373903002503 RNA binding pocket [nucleotide binding]; other site 373903002504 Sm2 motif; other site 373903002505 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 373903002506 NusA N-terminal domain; Region: NusA_N; pfam08529 373903002507 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 373903002508 RNA binding site [nucleotide binding]; other site 373903002509 homodimer interface [polypeptide binding]; other site 373903002510 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 373903002511 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 373903002512 G-X-X-G motif; other site 373903002513 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 373903002514 putative RNA binding cleft [nucleotide binding]; other site 373903002515 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 373903002516 translation initiation factor IF-2; Region: IF-2; TIGR00487 373903002517 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 373903002518 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 373903002519 G1 box; other site 373903002520 putative GEF interaction site [polypeptide binding]; other site 373903002521 GTP/Mg2+ binding site [chemical binding]; other site 373903002522 Switch I region; other site 373903002523 G2 box; other site 373903002524 G3 box; other site 373903002525 Switch II region; other site 373903002526 G4 box; other site 373903002527 G5 box; other site 373903002528 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 373903002529 Translation-initiation factor 2; Region: IF-2; pfam11987 373903002530 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 373903002531 Ribosome-binding factor A; Region: RBFA; cl00542 373903002532 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 373903002533 DHH family; Region: DHH; pfam01368 373903002534 DHHA1 domain; Region: DHHA1; pfam02272 373903002535 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 373903002536 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 373903002537 RNA binding site [nucleotide binding]; other site 373903002538 active site 373903002539 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 373903002540 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 373903002541 active site 373903002542 Riboflavin kinase; Region: Flavokinase; cl03312 373903002543 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 373903002544 16S/18S rRNA binding site [nucleotide binding]; other site 373903002545 S13e-L30e interaction site [polypeptide binding]; other site 373903002546 25S rRNA binding site [nucleotide binding]; other site 373903002547 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 373903002548 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 373903002549 RNase E interface [polypeptide binding]; other site 373903002550 trimer interface [polypeptide binding]; other site 373903002551 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 373903002552 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 373903002553 RNase E interface [polypeptide binding]; other site 373903002554 trimer interface [polypeptide binding]; other site 373903002555 active site 373903002556 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 373903002557 putative nucleic acid binding region [nucleotide binding]; other site 373903002558 G-X-X-G motif; other site 373903002559 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 373903002560 RNA binding site [nucleotide binding]; other site 373903002561 domain interface; other site 373903002562 endonuclease IV; Provisional; Region: PRK01060 373903002563 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 373903002564 AP (apurinic/apyrimidinic) site pocket; other site 373903002565 DNA interaction; other site 373903002566 Metal-binding active site; metal-binding site 373903002567 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 373903002568 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 373903002569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002571 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002572 putative peptidoglycan binding site; other site 373903002573 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903002574 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903002575 putative peptidoglycan binding site; other site 373903002576 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903002577 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373903002578 active site 373903002579 metal binding site [ion binding]; metal-binding site 373903002580 Sporulation and spore germination; Region: Germane; cl11253 373903002581 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 373903002582 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 373903002583 NodB motif; other site 373903002584 active site 373903002585 catalytic site [active] 373903002586 metal binding site [ion binding]; metal-binding site 373903002587 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 373903002588 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 373903002589 NodB motif; other site 373903002590 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 373903002591 trimer interface [polypeptide binding]; other site 373903002592 active site 373903002593 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 373903002594 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 373903002595 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 373903002596 homodimer interface [polypeptide binding]; other site 373903002597 substrate-cofactor binding pocket; other site 373903002598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903002599 catalytic residue [active] 373903002600 homoserine kinase; Provisional; Region: PRK01212 373903002601 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373903002602 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 373903002603 homoserine dehydrogenase; Provisional; Region: PRK06349 373903002604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002605 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 373903002606 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 373903002607 threonine synthase; Reviewed; Region: PRK06721 373903002608 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 373903002609 homodimer interface [polypeptide binding]; other site 373903002610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903002611 catalytic residue [active] 373903002612 aspartate kinase; Reviewed; Region: PRK06635 373903002613 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 373903002614 putative nucleotide binding site [chemical binding]; other site 373903002615 putative catalytic residues [active] 373903002616 putative Mg ion binding site [ion binding]; other site 373903002617 putative aspartate binding site [chemical binding]; other site 373903002618 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 373903002619 putative allosteric regulatory site; other site 373903002620 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 373903002621 putative allosteric regulatory residue; other site 373903002622 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 373903002623 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 373903002624 active site 373903002625 catalytic residues [active] 373903002626 metal binding site [ion binding]; metal-binding site 373903002627 tartrate dehydrogenase; Provisional; Region: PRK08194 373903002628 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 373903002629 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 373903002630 E-class dimer interface [polypeptide binding]; other site 373903002631 P-class dimer interface [polypeptide binding]; other site 373903002632 active site 373903002633 Cu2+ binding site [ion binding]; other site 373903002634 Zn2+ binding site [ion binding]; other site 373903002635 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 373903002636 putative ADP-ribose binding site [chemical binding]; other site 373903002637 putative active site [active] 373903002638 glycerol kinase; Provisional; Region: glpK; PRK00047 373903002639 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 373903002640 N- and C-terminal domain interface [polypeptide binding]; other site 373903002641 active site 373903002642 MgATP binding site [chemical binding]; other site 373903002643 catalytic site [active] 373903002644 metal binding site [ion binding]; metal-binding site 373903002645 glycerol binding site [chemical binding]; other site 373903002646 homotetramer interface [polypeptide binding]; other site 373903002647 homodimer interface [polypeptide binding]; other site 373903002648 FBP binding site [chemical binding]; other site 373903002649 protein IIAGlc interface [polypeptide binding]; other site 373903002650 Predicted dehydrogenase [General function prediction only]; Region: COG0579 373903002651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002652 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 373903002653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 373903002654 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373903002655 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 373903002656 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 373903002657 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 373903002658 putative dimer interface [polypeptide binding]; other site 373903002659 putative anticodon binding site; other site 373903002660 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 373903002661 homodimer interface [polypeptide binding]; other site 373903002662 motif 1; other site 373903002663 motif 2; other site 373903002664 active site 373903002665 motif 3; other site 373903002666 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 373903002667 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 373903002668 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 373903002669 DNA binding site [nucleotide binding] 373903002670 active site 373903002671 oligoendopeptidase F; Region: pepF; TIGR00181 373903002672 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 373903002673 active site 373903002674 Zn binding site [ion binding]; other site 373903002675 Esterase/lipase [General function prediction only]; Region: COG1647 373903002676 dipeptidase PepV; Reviewed; Region: PRK07318 373903002677 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 373903002678 active site 373903002679 metal binding site [ion binding]; metal-binding site 373903002680 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 373903002681 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 373903002682 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 373903002683 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 373903002684 active site 373903002685 HIGH motif; other site 373903002686 KMSK motif region; other site 373903002687 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 373903002688 tRNA binding surface [nucleotide binding]; other site 373903002689 anticodon binding site; other site 373903002690 T-box leader 373903002691 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 373903002692 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 373903002693 PYR/PP interface [polypeptide binding]; other site 373903002694 tetramer interface [polypeptide binding]; other site 373903002695 dimer interface [polypeptide binding]; other site 373903002696 TPP binding site [chemical binding]; other site 373903002697 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 373903002698 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 373903002699 TPP-binding site [chemical binding]; other site 373903002700 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 373903002701 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 373903002702 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373903002703 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 373903002704 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 373903002705 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373903002706 active site 373903002707 metal binding site [ion binding]; metal-binding site 373903002708 homotetramer interface [polypeptide binding]; other site 373903002709 Integral membrane protein DUF92; Region: DUF92; cl00793 373903002710 Nucleoside recognition; Region: Gate; cl00486 373903002711 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 373903002712 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 373903002713 active site 373903002714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_28; cd04687 373903002715 nudix motif; other site 373903002716 VanZ like family; Region: VanZ; cl01971 373903002717 Predicted membrane protein [Function unknown]; Region: COG4684 373903002718 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 373903002719 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 373903002720 Rhomboid family; Region: Rhomboid; cl11446 373903002721 Predicted nucleotide kinase [Nucleotide transport and metabolism]; Region: COG4088 373903002722 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 373903002723 YolD-like protein; Region: YolD; pfam08863 373903002724 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 373903002725 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 373903002726 Acylphosphatase; Region: Acylphosphatase; cl00551 373903002727 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903002729 Helix-turn-helix domains; Region: HTH; cl00088 373903002730 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 373903002731 Protein export membrane protein; Region: SecD_SecF; cl14618 373903002732 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 373903002733 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373903002734 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 373903002735 4Fe-4S binding domain; Region: Fer4; cl02805 373903002736 Cupin domain; Region: Cupin_2; cl09118 373903002737 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 373903002738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373903002739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002740 NAD(P) binding site [chemical binding]; other site 373903002741 active site 373903002742 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 373903002743 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 373903002744 catalytic motif [active] 373903002745 Zn binding site [ion binding]; other site 373903002746 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 373903002747 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 373903002748 Lumazine binding domain; Region: Lum_binding; pfam00677 373903002749 Lumazine binding domain; Region: Lum_binding; pfam00677 373903002750 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 373903002751 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 373903002752 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 373903002753 dimerization interface [polypeptide binding]; other site 373903002754 active site 373903002755 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 373903002756 homopentamer interface [polypeptide binding]; other site 373903002757 active site 373903002758 ABC transporter; Region: ABC_tran; pfam00005 373903002759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002760 Q-loop/lid; other site 373903002761 cystic fibrosis transmembrane conductor regulator (CFTR); Region: CFTR_protein; TIGR01271 373903002762 ABC transporter signature motif; other site 373903002763 Walker B; other site 373903002764 D-loop; other site 373903002765 H-loop/switch region; other site 373903002766 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002767 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002768 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 373903002769 THUMP domain; Region: THUMP; cl12076 373903002770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002771 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 373903002772 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 373903002773 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 373903002774 EamA-like transporter family; Region: EamA; cl01037 373903002775 EamA-like transporter family; Region: EamA; cl01037 373903002776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373903002777 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 373903002778 dihydrodipicolinate reductase; Provisional; Region: PRK00048 373903002779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002780 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 373903002781 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 373903002782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002783 NAD(P) binding site [chemical binding]; other site 373903002784 Flavoprotein; Region: Flavoprotein; cl08021 373903002785 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 373903002786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002787 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 373903002788 aspartate kinase I; Reviewed; Region: PRK08210 373903002789 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 373903002790 putative catalytic residues [active] 373903002791 putative nucleotide binding site [chemical binding]; other site 373903002792 putative aspartate binding site [chemical binding]; other site 373903002793 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373903002794 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373903002795 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 373903002796 dihydrodipicolinate synthase; Region: dapA; TIGR00674 373903002797 dimer interface [polypeptide binding]; other site 373903002798 active site 373903002799 catalytic residue [active] 373903002800 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 373903002801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903002802 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 373903002803 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 373903002804 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 373903002805 active site 373903002806 YlzJ-like protein; Region: YlzJ; pfam14035 373903002807 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373903002808 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373903002809 Bacitracin resistance protein BacA; Region: BacA; cl00858 373903002810 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 373903002811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903002812 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 373903002813 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 373903002814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903002815 DNA-binding site [nucleotide binding]; DNA binding site 373903002816 UTRA domain; Region: UTRA; cl01230 373903002817 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 373903002818 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 373903002819 Walker A/P-loop; other site 373903002820 ATP binding site [chemical binding]; other site 373903002821 Q-loop/lid; other site 373903002822 ABC transporter signature motif; other site 373903002823 Walker B; other site 373903002824 D-loop; other site 373903002825 H-loop/switch region; other site 373903002826 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 373903002827 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373903002828 TM-ABC transporter signature motif; other site 373903002829 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 373903002830 TM-ABC transporter signature motif; other site 373903002831 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 373903002832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903002833 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 373903002834 Survival protein SurE; Region: SurE; cl00448 373903002835 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 373903002836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903002837 ATP binding site [chemical binding]; other site 373903002838 putative Mg++ binding site [ion binding]; other site 373903002839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903002840 nucleotide binding region [chemical binding]; other site 373903002841 ATP-binding site [chemical binding]; other site 373903002842 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002843 Helix-turn-helix domains; Region: HTH; cl00088 373903002844 Rrf2 family protein; Region: rrf2_super; TIGR00738 373903002845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373903002846 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 373903002847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373903002848 catalytic residue [active] 373903002849 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 373903002850 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 373903002851 trimerization site [polypeptide binding]; other site 373903002852 active site 373903002853 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 373903002854 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 373903002855 Ligand Binding Site [chemical binding]; other site 373903002856 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 373903002857 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 373903002858 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 373903002859 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373903002860 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 373903002861 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 373903002862 RNA/DNA hybrid binding site [nucleotide binding]; other site 373903002863 active site 373903002864 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373903002865 metal binding site 2 [ion binding]; metal-binding site 373903002866 putative DNA binding helix; other site 373903002867 metal binding site 1 [ion binding]; metal-binding site 373903002868 dimer interface [polypeptide binding]; other site 373903002869 structural Zn2+ binding site [ion binding]; other site 373903002870 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 373903002871 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 373903002872 active site 373903002873 HIGH motif; other site 373903002874 dimer interface [polypeptide binding]; other site 373903002875 KMSKS motif; other site 373903002876 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 373903002877 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 373903002878 ATP-grasp domain; Region: ATP-grasp_4; cl03087 373903002879 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 373903002880 active site 373903002881 DNA polymerase IV; Validated; Region: PRK02406 373903002882 DNA binding site [nucleotide binding] 373903002883 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 373903002884 cell division protein MraZ; Reviewed; Region: PRK00326 373903002885 MraZ protein; Region: MraZ; pfam02381 373903002886 MraZ protein; Region: MraZ; pfam02381 373903002887 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 373903002888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002889 Septum formation initiator; Region: DivIC; cl11433 373903002890 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 373903002891 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373903002892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903002893 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 373903002894 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 373903002895 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 373903002896 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373903002897 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373903002898 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903002899 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373903002900 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 373903002901 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373903002902 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903002903 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 373903002904 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 373903002905 Mg++ binding site [ion binding]; other site 373903002906 putative catalytic motif [active] 373903002907 putative substrate binding site [chemical binding]; other site 373903002908 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 373903002909 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373903002910 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903002911 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 373903002912 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 373903002913 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 373903002914 active site 373903002915 homodimer interface [polypeptide binding]; other site 373903002916 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 373903002917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373903002918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373903002919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903002920 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 373903002921 Cell division protein FtsQ; Region: FtsQ; pfam03799 373903002922 cell division protein FtsA; Region: ftsA; TIGR01174 373903002923 Cell division protein FtsA; Region: FtsA; cl11496 373903002924 Cell division protein FtsA; Region: FtsA; cl11496 373903002925 cell division protein FtsZ; Validated; Region: PRK09330 373903002926 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 373903002927 nucleotide binding site [chemical binding]; other site 373903002928 SulA interaction site; other site 373903002929 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 373903002930 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 373903002931 sporulation sigma factor SigE; Reviewed; Region: PRK08301 373903002932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903002933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903002934 DNA binding residues [nucleotide binding] 373903002935 sporulation sigma factor SigG; Reviewed; Region: PRK08215 373903002936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903002937 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373903002938 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903002939 DNA binding residues [nucleotide binding] 373903002940 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 373903002941 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 373903002942 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 373903002943 ATP cone domain; Region: ATP-cone; pfam03477 373903002944 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 373903002945 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 373903002946 HlyD family secretion protein; Region: HlyD_2; pfam12700 373903002947 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 373903002948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 373903002949 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373903002950 catalytic residue [active] 373903002951 Protein of unknown function (DUF552); Region: DUF552; cl00775 373903002952 YGGT family; Region: YGGT; cl00508 373903002953 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 373903002954 DivIVA protein; Region: DivIVA; pfam05103 373903002955 DivIVA domain; Region: DivI1A_domain; TIGR03544 373903002956 T-box leader 373903002957 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 373903002958 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 373903002959 HIGH motif; other site 373903002960 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 373903002961 active site 373903002962 KMSKS motif; other site 373903002963 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 373903002964 tRNA binding surface [nucleotide binding]; other site 373903002965 anticodon binding site; other site 373903002966 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 373903002967 MatE; Region: MatE; cl10513 373903002968 MatE; Region: MatE; cl10513 373903002969 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 373903002970 threonine dehydratase; Provisional; Region: PRK08198 373903002971 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 373903002972 tetramer interface [polypeptide binding]; other site 373903002973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903002974 catalytic residue [active] 373903002975 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 373903002976 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 373903002977 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 373903002978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373903002979 RNA binding surface [nucleotide binding]; other site 373903002980 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 373903002981 active site 373903002982 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903002983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903002984 active site 373903002985 uracil-xanthine permease; Region: ncs2; TIGR00801 373903002986 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 373903002987 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 373903002988 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373903002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903002990 dihydroorotase; Validated; Region: pyrC; PRK09357 373903002991 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 373903002992 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 373903002993 active site 373903002994 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 373903002995 active site 373903002996 dimer interface [polypeptide binding]; other site 373903002997 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 373903002998 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 373903002999 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 373903003000 FAD binding pocket [chemical binding]; other site 373903003001 FAD binding motif [chemical binding]; other site 373903003002 phosphate binding motif [ion binding]; other site 373903003003 beta-alpha-beta structure motif; other site 373903003004 NAD binding pocket [chemical binding]; other site 373903003005 Iron coordination center [ion binding]; other site 373903003006 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 373903003007 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 373903003008 heterodimer interface [polypeptide binding]; other site 373903003009 active site 373903003010 FMN binding site [chemical binding]; other site 373903003011 homodimer interface [polypeptide binding]; other site 373903003012 substrate binding site [chemical binding]; other site 373903003013 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 373903003014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903003015 active site 373903003016 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903003017 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903003018 DNA binding site [nucleotide binding] 373903003019 domain linker motif; other site 373903003020 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 373903003021 ligand binding site [chemical binding]; other site 373903003022 putative transporter; Provisional; Region: PRK03699 373903003023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903003024 putative substrate translocation pore; other site 373903003025 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 373903003026 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 373903003027 Ca binding site [ion binding]; other site 373903003028 active site 373903003029 catalytic site [active] 373903003030 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 373903003031 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 373903003032 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 373903003033 active site 373903003034 catalytic site [active] 373903003035 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903003036 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903003037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903003038 dimer interface [polypeptide binding]; other site 373903003039 conserved gate region; other site 373903003040 putative PBP binding loops; other site 373903003041 ABC-ATPase subunit interface; other site 373903003042 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903003043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903003044 dimer interface [polypeptide binding]; other site 373903003045 conserved gate region; other site 373903003046 putative PBP binding loops; other site 373903003047 ABC-ATPase subunit interface; other site 373903003048 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903003049 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903003050 DNA binding site [nucleotide binding] 373903003051 domain linker motif; other site 373903003052 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903003053 dimerization interface [polypeptide binding]; other site 373903003054 ligand binding site [chemical binding]; other site 373903003055 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 373903003056 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 373903003057 putative ligand binding site [chemical binding]; other site 373903003058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 373903003059 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 373903003060 Walker A/P-loop; other site 373903003061 ATP binding site [chemical binding]; other site 373903003062 Q-loop/lid; other site 373903003063 ABC transporter signature motif; other site 373903003064 Walker B; other site 373903003065 D-loop; other site 373903003066 H-loop/switch region; other site 373903003067 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 373903003068 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373903003069 TM-ABC transporter signature motif; other site 373903003070 L-fucose isomerase; Provisional; Region: fucI; PRK10991 373903003071 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 373903003072 hexamer (dimer of trimers) interface [polypeptide binding]; other site 373903003073 trimer interface [polypeptide binding]; other site 373903003074 substrate binding site [chemical binding]; other site 373903003075 Mn binding site [ion binding]; other site 373903003076 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 373903003077 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 373903003078 N- and C-terminal domain interface [polypeptide binding]; other site 373903003079 putative active site [active] 373903003080 catalytic site [active] 373903003081 metal binding site [ion binding]; metal-binding site 373903003082 putative xylulose binding site [chemical binding]; other site 373903003083 putative ATP binding site [chemical binding]; other site 373903003084 putative homodimer interface [polypeptide binding]; other site 373903003085 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 373903003086 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 373903003087 N- and C-terminal domain interface [polypeptide binding]; other site 373903003088 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 373903003089 active site 373903003090 catalytic site [active] 373903003091 metal binding site [ion binding]; metal-binding site 373903003092 ATP binding site [chemical binding]; other site 373903003093 carbohydrate binding site [chemical binding]; other site 373903003094 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 373903003095 intersubunit interface [polypeptide binding]; other site 373903003096 active site 373903003097 Zn2+ binding site [ion binding]; other site 373903003098 RDD family; Region: RDD; cl00746 373903003099 peptidase T; Region: peptidase-T; TIGR01882 373903003100 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 373903003101 metal binding site [ion binding]; metal-binding site 373903003102 dimer interface [polypeptide binding]; other site 373903003103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903003104 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 373903003105 active site 373903003106 dimer interface [polypeptide binding]; other site 373903003107 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 373903003108 MG2 domain; Region: A2M_N; pfam01835 373903003109 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 373903003110 Alpha-2-macroglobulin family; Region: A2M; pfam00207 373903003111 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 373903003112 surface patch; other site 373903003113 thioester region; other site 373903003114 specificity defining residues; other site 373903003115 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 373903003116 Transglycosylase; Region: Transgly; cl07896 373903003117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903003118 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 373903003119 UV-endonuclease UvdE; Region: UvdE; cl10036 373903003120 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 373903003121 active site 373903003122 catalytic site [active] 373903003123 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 373903003124 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903003125 substrate binding site [chemical binding]; other site 373903003126 ATP binding site [chemical binding]; other site 373903003127 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373903003128 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 373903003129 active site 373903003130 metal binding site [ion binding]; metal-binding site 373903003131 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 373903003132 elongation factor G; Reviewed; Region: PRK12740 373903003133 G1 box; other site 373903003134 putative GEF interaction site [polypeptide binding]; other site 373903003135 GTP/Mg2+ binding site [chemical binding]; other site 373903003136 Switch I region; other site 373903003137 G2 box; other site 373903003138 G3 box; other site 373903003139 Switch II region; other site 373903003140 G4 box; other site 373903003141 G5 box; other site 373903003142 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373903003143 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373903003144 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373903003145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003146 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 373903003147 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373903003148 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 373903003149 substrate binding site [chemical binding]; other site 373903003150 B12 cofactor binding site [chemical binding]; other site 373903003151 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 373903003152 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 373903003153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373903003154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373903003155 ligand binding site [chemical binding]; other site 373903003156 flexible hinge region; other site 373903003157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373903003158 putative switch regulator; other site 373903003159 non-specific DNA interactions [nucleotide binding]; other site 373903003160 DNA binding site [nucleotide binding] 373903003161 sequence specific DNA binding site [nucleotide binding]; other site 373903003162 putative cAMP binding site [chemical binding]; other site 373903003163 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 373903003164 putative active site [active] 373903003165 catalytic triad [active] 373903003166 putative dimer interface [polypeptide binding]; other site 373903003167 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 373903003168 Domain of unknown function (DUF814); Region: DUF814; pfam05670 373903003169 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 373903003170 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 373903003171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373903003172 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 373903003173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903003174 motif II; other site 373903003175 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 373903003176 Domain of unknown function (DUF370); Region: DUF370; cl00898 373903003177 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 373903003178 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 373903003179 catalytic site [active] 373903003180 G-X2-G-X-G-K; other site 373903003181 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 373903003182 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 373903003183 Flavoprotein; Region: Flavoprotein; cl08021 373903003184 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 373903003185 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 373903003186 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903003187 S-adenosylmethionine synthetase; Validated; Region: PRK05250 373903003188 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 373903003189 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 373903003190 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 373903003191 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 373903003192 primosome assembly protein PriA; Validated; Region: PRK05580 373903003193 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373903003194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903003195 ATP binding site [chemical binding]; other site 373903003196 putative Mg++ binding site [ion binding]; other site 373903003197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903003198 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 373903003199 active site 373903003200 catalytic residues [active] 373903003201 metal binding site [ion binding]; metal-binding site 373903003202 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 373903003203 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 373903003204 putative active site [active] 373903003205 substrate binding site [chemical binding]; other site 373903003206 putative cosubstrate binding site; other site 373903003207 catalytic site [active] 373903003208 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 373903003209 substrate binding site [chemical binding]; other site 373903003210 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 373903003211 16S rRNA methyltransferase B; Provisional; Region: PRK14902 373903003212 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 373903003213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 373903003214 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 373903003215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903003216 FeS/SAM binding site; other site 373903003217 Protein phosphatase 2C; Region: PP2C; pfam00481 373903003218 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 373903003219 active site 373903003220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 373903003221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 373903003222 active site 373903003223 ATP binding site [chemical binding]; other site 373903003224 substrate binding site [chemical binding]; other site 373903003225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373903003226 substrate binding site [chemical binding]; other site 373903003227 activation loop (A-loop); other site 373903003228 activation loop (A-loop); other site 373903003229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 373903003230 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 373903003231 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 373903003232 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 373903003233 GTPase RsgA; Reviewed; Region: PRK00098 373903003234 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 373903003235 RNA binding site [nucleotide binding]; other site 373903003236 homodimer interface [polypeptide binding]; other site 373903003237 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 373903003238 GTPase/Zn-binding domain interface [polypeptide binding]; other site 373903003239 GTP/Mg2+ binding site [chemical binding]; other site 373903003240 G4 box; other site 373903003241 G5 box; other site 373903003242 G1 box; other site 373903003243 Switch I region; other site 373903003244 G2 box; other site 373903003245 G3 box; other site 373903003246 Switch II region; other site 373903003247 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 373903003248 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 373903003249 substrate binding site [chemical binding]; other site 373903003250 hexamer interface [polypeptide binding]; other site 373903003251 metal binding site [ion binding]; metal-binding site 373903003252 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 373903003253 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 373903003254 catalytic motif [active] 373903003255 Zn binding site [ion binding]; other site 373903003256 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 373903003257 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 373903003258 Lumazine binding domain; Region: Lum_binding; pfam00677 373903003259 Lumazine binding domain; Region: Lum_binding; pfam00677 373903003260 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 373903003261 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 373903003262 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 373903003263 dimerization interface [polypeptide binding]; other site 373903003264 active site 373903003265 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 373903003266 homopentamer interface [polypeptide binding]; other site 373903003267 active site 373903003268 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903003269 Thiamine pyrophosphokinase; Region: TPK; cd07995 373903003270 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 373903003271 active site 373903003272 dimerization interface [polypeptide binding]; other site 373903003273 thiamine binding site [chemical binding]; other site 373903003274 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 373903003275 Fumarase C-terminus; Region: Fumerase_C; cl00795 373903003276 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 373903003277 Malic enzyme, N-terminal domain; Region: malic; pfam00390 373903003278 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 373903003279 putative NAD(P) binding site [chemical binding]; other site 373903003280 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 373903003281 Asp23 family; Region: Asp23; cl00574 373903003282 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 373903003283 DAK2 domain; Region: Dak2; cl03685 373903003284 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903003285 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903003286 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 373903003287 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 373903003288 ssDNA binding site; other site 373903003289 generic binding surface II; other site 373903003290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903003291 ATP binding site [chemical binding]; other site 373903003292 putative Mg++ binding site [ion binding]; other site 373903003293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903003294 nucleotide binding region [chemical binding]; other site 373903003295 ATP-binding site [chemical binding]; other site 373903003296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903003297 S-adenosylmethionine binding site [chemical binding]; other site 373903003298 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 373903003299 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 373903003300 active site 373903003301 (T/H)XGH motif; other site 373903003302 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 373903003303 Nucleoside recognition; Region: Gate; cl00486 373903003304 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 373903003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903003306 motif II; other site 373903003307 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 373903003308 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 373903003309 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373903003310 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903003311 hypothetical protein; Provisional; Region: PRK13670 373903003312 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373903003313 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 373903003314 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 373903003315 Acetokinase family; Region: Acetate_kinase; cl01029 373903003316 propionate/acetate kinase; Provisional; Region: PRK12379 373903003317 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 373903003318 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 373903003319 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 373903003320 Helix-turn-helix domains; Region: HTH; cl00088 373903003321 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 373903003322 active site 2 [active] 373903003323 active site 1 [active] 373903003324 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 373903003325 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 373903003326 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 373903003327 dimer interface [polypeptide binding]; other site 373903003328 active site 373903003329 CoA binding pocket [chemical binding]; other site 373903003330 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 373903003331 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 373903003332 FMN binding site [chemical binding]; other site 373903003333 substrate binding site [chemical binding]; other site 373903003334 putative catalytic residue [active] 373903003335 Acyl transferase domain; Region: Acyl_transf_1; cl08282 373903003336 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373903003337 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373903003338 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 373903003339 NAD(P) binding site [chemical binding]; other site 373903003340 homotetramer interface [polypeptide binding]; other site 373903003341 homodimer interface [polypeptide binding]; other site 373903003342 active site 373903003343 Phosphopantetheine attachment site; Region: PP-binding; cl09936 373903003344 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 373903003345 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 373903003346 dimer interface [polypeptide binding]; other site 373903003347 active site 373903003348 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 373903003349 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373903003350 dimerization interface [polypeptide binding]; other site 373903003351 active site 373903003352 metal binding site [ion binding]; metal-binding site 373903003353 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 373903003354 dsRNA binding site [nucleotide binding]; other site 373903003355 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 373903003356 homotrimer interaction site [polypeptide binding]; other site 373903003357 active site 373903003358 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 373903003359 NeuB family; Region: NeuB; cl00496 373903003360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003361 Prephenate dehydrogenase; Region: PDH; pfam02153 373903003362 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 373903003363 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 373903003364 hinge; other site 373903003365 active site 373903003366 EamA-like transporter family; Region: EamA; cl01037 373903003367 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 373903003368 EamA-like transporter family; Region: EamA; cl01037 373903003369 cytidylate kinase; Provisional; Region: cmk; PRK00023 373903003370 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 373903003371 CMP-binding site; other site 373903003372 The sites determining sugar specificity; other site 373903003373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 373903003374 putative acyl-acceptor binding pocket; other site 373903003375 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 373903003376 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903003377 GAF domain; Region: GAF; cl15785 373903003378 Histidine kinase; Region: His_kinase; pfam06580 373903003379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903003380 ATP binding site [chemical binding]; other site 373903003381 Mg2+ binding site [ion binding]; other site 373903003382 G-X-G motif; other site 373903003383 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 373903003384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903003385 active site 373903003386 phosphorylation site [posttranslational modification] 373903003387 intermolecular recognition site; other site 373903003388 dimerization interface [polypeptide binding]; other site 373903003389 LytTr DNA-binding domain; Region: LytTR; cl04498 373903003390 Carbon starvation protein CstA; Region: CstA; pfam02554 373903003391 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 373903003392 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 373903003393 octamerization interface [polypeptide binding]; other site 373903003394 diferric-oxygen binding site [ion binding]; other site 373903003395 LytB protein; Region: LYTB; cl00507 373903003396 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 373903003397 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 373903003398 RNA binding site [nucleotide binding]; other site 373903003399 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 373903003400 RNA binding site [nucleotide binding]; other site 373903003401 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 373903003402 RNA binding site [nucleotide binding]; other site 373903003403 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 373903003404 RNA binding site [nucleotide binding]; other site 373903003405 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 373903003406 stage II sporulation protein P; Region: spore_II_P; TIGR02867 373903003407 YIEGIA protein; Region: YIEGIA; pfam14045 373903003408 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 373903003409 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 373903003410 GTP-binding protein Der; Reviewed; Region: PRK00093 373903003411 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 373903003412 G1 box; other site 373903003413 GTP/Mg2+ binding site [chemical binding]; other site 373903003414 Switch I region; other site 373903003415 G2 box; other site 373903003416 Switch II region; other site 373903003417 G3 box; other site 373903003418 G4 box; other site 373903003419 G5 box; other site 373903003420 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 373903003421 G1 box; other site 373903003422 GTP/Mg2+ binding site [chemical binding]; other site 373903003423 Switch I region; other site 373903003424 G2 box; other site 373903003425 G3 box; other site 373903003426 Switch II region; other site 373903003427 G4 box; other site 373903003428 G5 box; other site 373903003429 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 373903003430 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 373903003431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003432 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 373903003433 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 373903003434 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373903003435 IHF dimer interface [polypeptide binding]; other site 373903003436 IHF - DNA interface [nucleotide binding]; other site 373903003437 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 373903003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003439 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 373903003440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003441 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 373903003442 OsmC-like protein; Region: OsmC; cl00767 373903003443 Cation transport protein; Region: TrkH; cl10514 373903003444 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 373903003445 Response regulator receiver domain; Region: Response_reg; pfam00072 373903003446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903003447 active site 373903003448 phosphorylation site [posttranslational modification] 373903003449 intermolecular recognition site; other site 373903003450 dimerization interface [polypeptide binding]; other site 373903003451 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 373903003452 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 373903003453 dimerization interface [polypeptide binding]; other site 373903003454 domain crossover interface; other site 373903003455 redox-dependent activation switch; other site 373903003456 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 373903003457 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 373903003458 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 373903003459 active site 373903003460 putative substrate binding pocket [chemical binding]; other site 373903003461 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 373903003462 MPN+ (JAMM) motif; other site 373903003463 Zinc-binding site [ion binding]; other site 373903003464 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 373903003465 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 373903003466 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 373903003467 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373903003468 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373903003469 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373903003470 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373903003471 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 373903003472 MFS_1 like family; Region: MFS_1_like; pfam12832 373903003473 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 373903003474 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 373903003475 HEAT repeats; Region: HEAT_2; pfam13646 373903003476 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 373903003477 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 373903003478 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 373903003479 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 373903003480 active site 373903003481 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903003482 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 373903003483 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373903003484 minor groove reading motif; other site 373903003485 helix-hairpin-helix signature motif; other site 373903003486 substrate binding pocket [chemical binding]; other site 373903003487 active site 373903003488 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 373903003489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003490 binding surface 373903003491 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373903003492 TPR motif; other site 373903003493 TPR repeat; Region: TPR_11; pfam13414 373903003494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003495 binding surface 373903003496 TPR motif; other site 373903003497 TPR repeat; Region: TPR_11; pfam13414 373903003498 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 373903003499 homodimer interface [polypeptide binding]; other site 373903003500 substrate-cofactor binding pocket; other site 373903003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903003502 catalytic residue [active] 373903003503 Dehydratase family; Region: ILVD_EDD; cl00340 373903003504 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 373903003505 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373903003506 PYR/PP interface [polypeptide binding]; other site 373903003507 dimer interface [polypeptide binding]; other site 373903003508 TPP binding site [chemical binding]; other site 373903003509 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 373903003510 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 373903003511 TPP-binding site [chemical binding]; other site 373903003512 dimer interface [polypeptide binding]; other site 373903003513 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 373903003514 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 373903003515 putative valine binding site [chemical binding]; other site 373903003516 dimer interface [polypeptide binding]; other site 373903003517 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 373903003518 ketol-acid reductoisomerase; Provisional; Region: PRK05479 373903003519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003520 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 373903003521 2-isopropylmalate synthase; Validated; Region: PRK00915 373903003522 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 373903003523 active site 373903003524 catalytic residues [active] 373903003525 metal binding site [ion binding]; metal-binding site 373903003526 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 373903003527 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 373903003528 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 373903003529 substrate binding site [chemical binding]; other site 373903003530 ligand binding site [chemical binding]; other site 373903003531 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 373903003532 substrate binding site [chemical binding]; other site 373903003533 tartrate dehydrogenase; Provisional; Region: PRK08194 373903003534 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 373903003535 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 373903003536 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 373903003537 active site 373903003538 catalytic residues [active] 373903003539 metal binding site [ion binding]; metal-binding site 373903003540 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 373903003541 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 373903003542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373903003543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903003544 homodimer interface [polypeptide binding]; other site 373903003545 catalytic residue [active] 373903003546 Domain of unknown function (DUF296); Region: DUF296; cl00720 373903003547 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 373903003548 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 373903003549 putative active site [active] 373903003550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903003551 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373903003552 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 373903003553 DNA binding residues [nucleotide binding] 373903003554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003555 binding surface 373903003556 TPR motif; other site 373903003557 TPR repeat; Region: TPR_11; pfam13414 373903003558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003559 binding surface 373903003560 TPR motif; other site 373903003561 Stage II sporulation protein; Region: SpoIID; pfam08486 373903003562 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 373903003563 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903003564 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003565 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373903003566 putative peptidoglycan binding site; other site 373903003567 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003568 putative peptidoglycan binding site; other site 373903003569 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903003570 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 373903003571 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903003572 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003573 putative peptidoglycan binding site; other site 373903003574 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903003575 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003576 putative peptidoglycan binding site; other site 373903003577 Peptidase family M23; Region: Peptidase_M23; pfam01551 373903003578 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 373903003579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903003580 FeS/SAM binding site; other site 373903003581 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 373903003582 ATP cone domain; Region: ATP-cone; pfam03477 373903003583 Class III ribonucleotide reductase; Region: RNR_III; cd01675 373903003584 effector binding site; other site 373903003585 active site 373903003586 Zn binding site [ion binding]; other site 373903003587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903003588 Radical SAM superfamily; Region: Radical_SAM; pfam04055 373903003589 FeS/SAM binding site; other site 373903003590 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 373903003591 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 373903003592 active site 373903003593 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 373903003594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373903003595 DNA binding site [nucleotide binding] 373903003596 Int/Topo IB signature motif; other site 373903003597 active site 373903003598 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 373903003599 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 373903003600 OPT oligopeptide transporter protein; Region: OPT; cl14607 373903003601 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 373903003602 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 373903003603 HflX GTPase family; Region: HflX; cd01878 373903003604 G1 box; other site 373903003605 GTP/Mg2+ binding site [chemical binding]; other site 373903003606 Switch I region; other site 373903003607 G2 box; other site 373903003608 G3 box; other site 373903003609 Switch II region; other site 373903003610 G4 box; other site 373903003611 G5 box; other site 373903003612 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 373903003613 active site 373903003614 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903003615 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 373903003616 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373903003617 C-terminal domain interface [polypeptide binding]; other site 373903003618 GSH binding site (G-site) [chemical binding]; other site 373903003619 dimer interface [polypeptide binding]; other site 373903003620 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 373903003621 putative FMN binding site [chemical binding]; other site 373903003622 Cupin domain; Region: Cupin_2; cl09118 373903003623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903003624 H+ Antiporter protein; Region: 2A0121; TIGR00900 373903003625 putative substrate translocation pore; other site 373903003626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903003627 dimerization interface [polypeptide binding]; other site 373903003628 putative DNA binding site [nucleotide binding]; other site 373903003629 putative Zn2+ binding site [ion binding]; other site 373903003630 TPR repeat; Region: TPR_11; pfam13414 373903003631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003632 binding surface 373903003633 TPR motif; other site 373903003634 TPR repeat; Region: TPR_11; pfam13414 373903003635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373903003636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003637 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 373903003638 Protein of unknown function (DUF456); Region: DUF456; cl01069 373903003639 Flavin Reductases; Region: FlaRed; cl00801 373903003640 DJ-1 family protein; Region: not_thiJ; TIGR01383 373903003641 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 373903003642 conserved cys residue [active] 373903003643 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 373903003644 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903003645 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 373903003646 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 373903003647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903003648 catalytic residue [active] 373903003649 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003650 putative peptidoglycan binding site; other site 373903003651 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903003652 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003653 putative peptidoglycan binding site; other site 373903003654 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003655 putative peptidoglycan binding site; other site 373903003656 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 373903003657 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 373903003658 catalytic residues [active] 373903003659 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 373903003660 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903003661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 373903003662 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 373903003663 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 373903003664 catalytic residues [active] 373903003665 catalytic nucleophile [active] 373903003666 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903003667 putative peptidoglycan binding site; other site 373903003668 LexA repressor; Validated; Region: PRK00215 373903003669 Helix-turn-helix domains; Region: HTH; cl00088 373903003670 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373903003671 Catalytic site [active] 373903003672 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 373903003673 Fe-S cluster binding site [ion binding]; other site 373903003674 active site 373903003675 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 373903003676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903003677 dimer interface [polypeptide binding]; other site 373903003678 conserved gate region; other site 373903003679 putative PBP binding loops; other site 373903003680 ABC-ATPase subunit interface; other site 373903003681 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 373903003682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 373903003683 Walker A/P-loop; other site 373903003684 ATP binding site [chemical binding]; other site 373903003685 Q-loop/lid; other site 373903003686 ABC transporter signature motif; other site 373903003687 Walker B; other site 373903003688 D-loop; other site 373903003689 H-loop/switch region; other site 373903003690 NMT1-like family; Region: NMT1_2; cl15260 373903003691 NMT1/THI5 like; Region: NMT1; pfam09084 373903003692 histidinol-phosphatase; Provisional; Region: PRK07328 373903003693 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 373903003694 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 373903003695 homodimer interface [polypeptide binding]; other site 373903003696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903003697 catalytic residue [active] 373903003698 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 373903003699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003700 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 373903003701 putative L-serine binding site [chemical binding]; other site 373903003702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003703 binding surface 373903003704 TPR motif; other site 373903003705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373903003706 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 373903003707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373903003708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903003709 homodimer interface [polypeptide binding]; other site 373903003710 catalytic residue [active] 373903003711 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 373903003712 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 373903003713 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 373903003714 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 373903003715 Sm1 motif; other site 373903003716 D3 - B interaction site; other site 373903003717 D1 - D2 interaction site; other site 373903003718 Hfq - Hfq interaction site; other site 373903003719 RNA binding pocket [nucleotide binding]; other site 373903003720 Sm2 motif; other site 373903003721 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373903003722 G1 box; other site 373903003723 GTP/Mg2+ binding site [chemical binding]; other site 373903003724 G2 box; other site 373903003725 Switch I region; other site 373903003726 G3 box; other site 373903003727 Switch II region; other site 373903003728 G4 box; other site 373903003729 G5 box; other site 373903003730 stage V sporulation protein K; Region: spore_V_K; TIGR02881 373903003731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903003732 Walker A motif; other site 373903003733 ATP binding site [chemical binding]; other site 373903003734 Walker B motif; other site 373903003735 arginine finger; other site 373903003736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003737 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 373903003738 ydaO/yuaA leader 373903003739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903003740 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 373903003741 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 373903003742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903003743 ATP binding site [chemical binding]; other site 373903003744 Mg2+ binding site [ion binding]; other site 373903003745 G-X-G motif; other site 373903003746 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 373903003747 ATP binding site [chemical binding]; other site 373903003748 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 373903003749 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 373903003750 MutS domain I; Region: MutS_I; pfam01624 373903003751 MutS domain II; Region: MutS_II; pfam05188 373903003752 MutS family domain IV; Region: MutS_IV; pfam05190 373903003753 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 373903003754 Walker A/P-loop; other site 373903003755 ATP binding site [chemical binding]; other site 373903003756 Q-loop/lid; other site 373903003757 ABC transporter signature motif; other site 373903003758 Walker B; other site 373903003759 D-loop; other site 373903003760 H-loop/switch region; other site 373903003761 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 373903003762 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373903003763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903003764 FeS/SAM binding site; other site 373903003765 TRAM domain; Region: TRAM; cl01282 373903003766 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 373903003767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903003768 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 373903003769 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 373903003770 Cation transport protein; Region: TrkH; cl10514 373903003771 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 373903003772 Cation transport protein; Region: TrkH; cl10514 373903003773 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 373903003774 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 373903003775 Cl- selectivity filter; other site 373903003776 Cl- binding residues [ion binding]; other site 373903003777 pore gating glutamate residue; other site 373903003778 dimer interface [polypeptide binding]; other site 373903003779 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 373903003780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903003781 ATP binding site [chemical binding]; other site 373903003782 Mg2+ binding site [ion binding]; other site 373903003783 G-X-G motif; other site 373903003784 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 373903003785 anchoring element; other site 373903003786 dimer interface [polypeptide binding]; other site 373903003787 ATP binding site [chemical binding]; other site 373903003788 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 373903003789 active site 373903003790 putative metal-binding site [ion binding]; other site 373903003791 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373903003792 DNA gyrase subunit A; Validated; Region: PRK05560 373903003793 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 373903003794 CAP-like domain; other site 373903003795 active site 373903003796 primary dimer interface [polypeptide binding]; other site 373903003797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903003798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903003799 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373903003800 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903003801 S-layer homology domain; Region: SLH; pfam00395 373903003802 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 373903003803 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 373903003804 dockerin binding interface; other site 373903003805 Gram-negative bacterial tonB protein; Region: TonB; cl10048 373903003806 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 373903003807 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 373903003808 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 373903003809 Nucleoside recognition; Region: Gate; cl00486 373903003810 Nucleoside recognition; Region: Gate; cl00486 373903003811 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 373903003812 phosphodiesterase; Provisional; Region: PRK12704 373903003813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903003814 RecX family; Region: RecX; cl00936 373903003815 recombinase A; Provisional; Region: recA; PRK09354 373903003816 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 373903003817 hexamer interface [polypeptide binding]; other site 373903003818 Walker A motif; other site 373903003819 ATP binding site [chemical binding]; other site 373903003820 Walker B motif; other site 373903003821 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 373903003822 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 373903003823 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 373903003824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003825 TPR motif; other site 373903003826 binding surface 373903003827 TPR repeat; Region: TPR_11; pfam13414 373903003828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373903003829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003830 binding surface 373903003831 TPR motif; other site 373903003832 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373903003833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003834 binding surface 373903003835 TPR motif; other site 373903003836 TPR repeat; Region: TPR_11; pfam13414 373903003837 competence damage-inducible protein A; Provisional; Region: PRK00549 373903003838 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 373903003839 putative MPT binding site; other site 373903003840 Competence-damaged protein; Region: CinA; cl00666 373903003841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903003842 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373903003843 Walker A motif; other site 373903003844 ATP binding site [chemical binding]; other site 373903003845 Walker B motif; other site 373903003846 arginine finger; other site 373903003847 Peptidase family M41; Region: Peptidase_M41; pfam01434 373903003848 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 373903003849 tetramer interfaces [polypeptide binding]; other site 373903003850 binuclear metal-binding site [ion binding]; other site 373903003851 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 373903003852 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 373903003853 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373903003854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903003855 FeS/SAM binding site; other site 373903003856 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 373903003857 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 373903003858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903003859 S-adenosylmethionine binding site [chemical binding]; other site 373903003860 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903003861 Uncharacterized conserved protein [Function unknown]; Region: COG1739 373903003862 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 373903003863 recombination factor protein RarA; Reviewed; Region: PRK13342 373903003864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903003865 Walker A motif; other site 373903003866 ATP binding site [chemical binding]; other site 373903003867 Walker B motif; other site 373903003868 arginine finger; other site 373903003869 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 373903003870 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 373903003871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 373903003872 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 373903003873 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 373903003874 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 373903003875 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 373903003876 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 373903003877 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 373903003878 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 373903003879 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 373903003880 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 373903003881 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 373903003882 dimer interface [polypeptide binding]; other site 373903003883 anticodon binding site; other site 373903003884 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 373903003885 homodimer interface [polypeptide binding]; other site 373903003886 motif 1; other site 373903003887 active site 373903003888 motif 2; other site 373903003889 GAD domain; Region: GAD; pfam02938 373903003890 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 373903003891 motif 3; other site 373903003892 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 373903003893 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 373903003894 dimer interface [polypeptide binding]; other site 373903003895 motif 1; other site 373903003896 active site 373903003897 motif 2; other site 373903003898 motif 3; other site 373903003899 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 373903003900 anticodon binding site; other site 373903003901 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 373903003902 PPIC-type PPIASE domain; Region: Rotamase; cl08278 373903003903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903003904 TPR motif; other site 373903003905 binding surface 373903003906 TPR repeat; Region: TPR_11; pfam13414 373903003907 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903003908 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 373903003909 putative active site [active] 373903003910 dimerization interface [polypeptide binding]; other site 373903003911 putative tRNAtyr binding site [nucleotide binding]; other site 373903003912 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 373903003913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903003914 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 373903003915 synthetase active site [active] 373903003916 NTP binding site [chemical binding]; other site 373903003917 metal binding site [ion binding]; metal-binding site 373903003918 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 373903003919 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 373903003920 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 373903003921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903003922 active site 373903003923 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 373903003924 DHH family; Region: DHH; pfam01368 373903003925 DHHA1 domain; Region: DHHA1; pfam02272 373903003926 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 373903003927 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373903003928 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 373903003929 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 373903003930 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 373903003931 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 373903003932 Protein export membrane protein; Region: SecD_SecF; cl14618 373903003933 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 373903003934 Protein export membrane protein; Region: SecD_SecF; cl14618 373903003935 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373903003936 Catalytic site [active] 373903003937 Preprotein translocase subunit; Region: YajC; cl00806 373903003938 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 373903003939 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 373903003940 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 373903003941 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 373903003942 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 373903003943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903003944 Walker A motif; other site 373903003945 ATP binding site [chemical binding]; other site 373903003946 Walker B motif; other site 373903003947 arginine finger; other site 373903003948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 373903003949 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 373903003950 RuvA N terminal domain; Region: RuvA_N; pfam01330 373903003951 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 373903003952 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 373903003953 active site 373903003954 putative DNA-binding cleft [nucleotide binding]; other site 373903003955 dimer interface [polypeptide binding]; other site 373903003956 BofC C-terminal domain; Region: BofC_C; pfam08955 373903003957 Transcriptional regulator; Region: Transcrip_reg; cl00361 373903003958 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 373903003959 GAF domain; Region: GAF_2; pfam13185 373903003960 GAF domain; Region: GAF; cl15785 373903003961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373903003962 metal binding site [ion binding]; metal-binding site 373903003963 active site 373903003964 I-site; other site 373903003965 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 373903003966 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 373903003967 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 373903003968 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 373903003969 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 373903003970 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373903003971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903003972 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373903003973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903003974 DNA binding residues [nucleotide binding] 373903003975 DNA primase; Validated; Region: dnaG; PRK05667 373903003976 CHC2 zinc finger; Region: zf-CHC2; cl15369 373903003977 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 373903003978 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 373903003979 active site 373903003980 metal binding site [ion binding]; metal-binding site 373903003981 interdomain interaction site; other site 373903003982 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 373903003983 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 373903003984 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903003985 Zn2+ binding site [ion binding]; other site 373903003986 Mg2+ binding site [ion binding]; other site 373903003987 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 373903003988 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 373903003989 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 373903003990 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 373903003991 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 373903003992 dimer interface [polypeptide binding]; other site 373903003993 motif 1; other site 373903003994 active site 373903003995 motif 2; other site 373903003996 motif 3; other site 373903003997 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 373903003998 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 373903003999 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 373903004000 Recombination protein O N terminal; Region: RecO_N; cl15812 373903004001 Recombination protein O C terminal; Region: RecO_C; pfam02565 373903004002 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 373903004003 intersubunit interface [polypeptide binding]; other site 373903004004 active site 373903004005 catalytic residue [active] 373903004006 MgtE intracellular N domain; Region: MgtE_N; cl15244 373903004007 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 373903004008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 373903004009 Divalent cation transporter; Region: MgtE; cl00786 373903004010 GTPase Era; Reviewed; Region: era; PRK00089 373903004011 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 373903004012 G1 box; other site 373903004013 GTP/Mg2+ binding site [chemical binding]; other site 373903004014 Switch I region; other site 373903004015 G2 box; other site 373903004016 Switch II region; other site 373903004017 G3 box; other site 373903004018 G4 box; other site 373903004019 G5 box; other site 373903004020 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 373903004021 active site 373903004022 catalytic motif [active] 373903004023 Zn binding site [ion binding]; other site 373903004024 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 373903004025 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 373903004026 Protein of unknown function (DUF502); Region: DUF502; cl01107 373903004027 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 373903004028 Domain of unknown function DUF21; Region: DUF21; pfam01595 373903004029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373903004030 Transporter associated domain; Region: CorC_HlyC; cl08393 373903004031 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 373903004032 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 373903004033 active site 373903004034 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 373903004035 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 373903004036 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 373903004037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903004038 Zn2+ binding site [ion binding]; other site 373903004039 Mg2+ binding site [ion binding]; other site 373903004040 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 373903004041 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004042 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 373903004043 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 373903004044 YabP family; Region: YabP; cl06766 373903004045 Protein of unknown function (DUF421); Region: DUF421; cl00990 373903004046 phage assembly protein; Region: IV; PHA00019 373903004047 Secretin and TonB N terminus short domain; Region: STN; cl06624 373903004048 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 373903004049 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 373903004050 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 373903004051 putative active site [active] 373903004052 Helix-turn-helix domains; Region: HTH; cl00088 373903004053 FOG: CBS domain [General function prediction only]; Region: COG0517 373903004054 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 373903004055 phosphoenolpyruvate synthase; Validated; Region: PRK06464 373903004056 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 373903004057 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 373903004058 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 373903004059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903004060 Zn2+ binding site [ion binding]; other site 373903004061 Mg2+ binding site [ion binding]; other site 373903004062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903004063 Zn2+ binding site [ion binding]; other site 373903004064 Mg2+ binding site [ion binding]; other site 373903004065 GatB domain; Region: GatB_Yqey; cl11497 373903004066 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 373903004067 nucleotide binding site/active site [active] 373903004068 HIT family signature motif; other site 373903004069 catalytic residue [active] 373903004070 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 373903004071 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373903004072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903004073 FeS/SAM binding site; other site 373903004074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 373903004075 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 373903004076 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 373903004077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903004078 chaperone protein DnaJ; Provisional; Region: PRK10767 373903004079 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373903004080 HSP70 interaction site [polypeptide binding]; other site 373903004081 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 373903004082 substrate binding site [polypeptide binding]; other site 373903004083 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 373903004084 Zn binding sites [ion binding]; other site 373903004085 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373903004086 dimer interface [polypeptide binding]; other site 373903004087 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 373903004088 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 373903004089 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 373903004090 heat shock protein GrpE; Provisional; Region: PRK14141 373903004091 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 373903004092 dimer interface [polypeptide binding]; other site 373903004093 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 373903004094 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 373903004095 HrcA protein C terminal domain; Region: HrcA; pfam01628 373903004096 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 373903004097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903004098 FeS/SAM binding site; other site 373903004099 HemN C-terminal domain; Region: HemN_C; pfam06969 373903004100 GTP-binding protein LepA; Provisional; Region: PRK05433 373903004101 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 373903004102 G1 box; other site 373903004103 putative GEF interaction site [polypeptide binding]; other site 373903004104 GTP/Mg2+ binding site [chemical binding]; other site 373903004105 Switch I region; other site 373903004106 G2 box; other site 373903004107 G3 box; other site 373903004108 Switch II region; other site 373903004109 G4 box; other site 373903004110 G5 box; other site 373903004111 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 373903004112 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 373903004113 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 373903004114 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 373903004115 stage II sporulation protein P; Region: spore_II_P; TIGR02867 373903004116 Germination protease; Region: Peptidase_A25; cl04057 373903004117 Membrane protein of unknown function; Region: DUF360; cl00850 373903004118 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 373903004119 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 373903004120 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 373903004121 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 373903004122 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 373903004123 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 373903004124 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 373903004125 Competence protein; Region: Competence; cl00471 373903004126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903004127 SLBB domain; Region: SLBB; pfam10531 373903004128 comEA protein; Region: comE; TIGR01259 373903004129 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 373903004130 EamA-like transporter family; Region: EamA; cl01037 373903004131 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 373903004132 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 373903004133 peroxiredoxin; Provisional; Region: PRK13189 373903004134 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 373903004135 dimer interface [polypeptide binding]; other site 373903004136 decamer (pentamer of dimers) interface [polypeptide binding]; other site 373903004137 catalytic triad [active] 373903004138 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 373903004139 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 373903004140 ATP-binding site [chemical binding]; other site 373903004141 Sugar specificity; other site 373903004142 Pyrimidine base specificity; other site 373903004143 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 373903004144 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 373903004145 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 373903004146 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 373903004147 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 373903004148 ABC-2 type transporter; Region: ABC2_membrane; cl11417 373903004149 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 373903004150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004151 Walker A/P-loop; other site 373903004152 ATP binding site [chemical binding]; other site 373903004153 Q-loop/lid; other site 373903004154 ABC transporter signature motif; other site 373903004155 Walker B; other site 373903004156 D-loop; other site 373903004157 H-loop/switch region; other site 373903004158 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 373903004159 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 373903004160 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 373903004161 Walker A/P-loop; other site 373903004162 ATP binding site [chemical binding]; other site 373903004163 Q-loop/lid; other site 373903004164 ABC transporter signature motif; other site 373903004165 Walker B; other site 373903004166 D-loop; other site 373903004167 H-loop/switch region; other site 373903004168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373903004169 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 373903004170 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 373903004171 Walker A/P-loop; other site 373903004172 ATP binding site [chemical binding]; other site 373903004173 Q-loop/lid; other site 373903004174 ABC transporter signature motif; other site 373903004175 Walker B; other site 373903004176 D-loop; other site 373903004177 H-loop/switch region; other site 373903004178 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373903004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004180 dimer interface [polypeptide binding]; other site 373903004181 conserved gate region; other site 373903004182 putative PBP binding loops; other site 373903004183 ABC-ATPase subunit interface; other site 373903004184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004185 dimer interface [polypeptide binding]; other site 373903004186 conserved gate region; other site 373903004187 putative PBP binding loops; other site 373903004188 ABC-ATPase subunit interface; other site 373903004189 potential frameshift: common BLAST hit: gi|42526582|ref|NP_971680.1| putative lipoprotein 373903004190 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 373903004191 Predicted solute binding protein [General function prediction only]; Region: COG3889 373903004192 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 373903004193 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 373903004194 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373903004195 putative NAD(P) binding site [chemical binding]; other site 373903004196 catalytic Zn binding site [ion binding]; other site 373903004197 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 373903004198 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 373903004199 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373903004200 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903004201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004202 dimer interface [polypeptide binding]; other site 373903004203 conserved gate region; other site 373903004204 putative PBP binding loops; other site 373903004205 ABC-ATPase subunit interface; other site 373903004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004207 dimer interface [polypeptide binding]; other site 373903004208 conserved gate region; other site 373903004209 putative PBP binding loops; other site 373903004210 ABC-ATPase subunit interface; other site 373903004211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903004212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903004213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903004214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903004215 DNA binding site [nucleotide binding] 373903004216 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 373903004217 putative dimerization interface [polypeptide binding]; other site 373903004218 putative ligand binding site [chemical binding]; other site 373903004219 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 373903004220 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 373903004221 active site 373903004222 catalytic site [active] 373903004223 metal binding site [ion binding]; metal-binding site 373903004224 dimer interface [polypeptide binding]; other site 373903004225 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 373903004226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903004227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004228 dimer interface [polypeptide binding]; other site 373903004229 conserved gate region; other site 373903004230 putative PBP binding loops; other site 373903004231 ABC-ATPase subunit interface; other site 373903004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004233 dimer interface [polypeptide binding]; other site 373903004234 conserved gate region; other site 373903004235 putative PBP binding loops; other site 373903004236 ABC-ATPase subunit interface; other site 373903004237 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903004238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903004239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903004240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903004241 DNA binding site [nucleotide binding] 373903004242 domain linker motif; other site 373903004243 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903004244 dimerization interface [polypeptide binding]; other site 373903004245 ligand binding site [chemical binding]; other site 373903004246 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373903004247 active site 373903004248 metal binding site [ion binding]; metal-binding site 373903004249 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 373903004250 FMN binding site [chemical binding]; other site 373903004251 dimer interface [polypeptide binding]; other site 373903004252 CAAX protease self-immunity; Region: Abi; cl00558 373903004253 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 373903004254 DNA polymerase IV; Reviewed; Region: PRK03103 373903004255 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 373903004256 active site 373903004257 DNA binding site [nucleotide binding] 373903004258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903004259 active site 373903004260 motif I; other site 373903004261 motif II; other site 373903004262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373903004263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903004264 active site 373903004265 phosphorylation site [posttranslational modification] 373903004266 intermolecular recognition site; other site 373903004267 dimerization interface [polypeptide binding]; other site 373903004268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373903004269 DNA binding site [nucleotide binding] 373903004270 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 373903004271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903004272 dimerization interface [polypeptide binding]; other site 373903004273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373903004274 dimer interface [polypeptide binding]; other site 373903004275 phosphorylation site [posttranslational modification] 373903004276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903004277 ATP binding site [chemical binding]; other site 373903004278 Mg2+ binding site [ion binding]; other site 373903004279 G-X-G motif; other site 373903004280 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 373903004281 dimer interface [polypeptide binding]; other site 373903004282 LysE type translocator; Region: LysE; cl00565 373903004283 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 373903004284 putative homotetramer interface [polypeptide binding]; other site 373903004285 putative homodimer interface [polypeptide binding]; other site 373903004286 putative allosteric switch controlling residues; other site 373903004287 putative metal binding site [ion binding]; other site 373903004288 putative homodimer-homodimer interface [polypeptide binding]; other site 373903004289 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 373903004290 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373903004291 metal-binding site [ion binding] 373903004292 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 373903004293 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 373903004294 G1 box; other site 373903004295 GTP/Mg2+ binding site [chemical binding]; other site 373903004296 Switch I region; other site 373903004297 G2 box; other site 373903004298 G3 box; other site 373903004299 Switch II region; other site 373903004300 G4 box; other site 373903004301 G5 box; other site 373903004302 Nucleoside recognition; Region: Gate; cl00486 373903004303 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 373903004304 Nucleoside recognition; Region: Gate; cl00486 373903004305 FeoA domain; Region: FeoA; cl00838 373903004306 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 373903004307 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 373903004308 HIGH motif; other site 373903004309 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373903004310 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 373903004311 active site 373903004312 KMSKS motif; other site 373903004313 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 373903004314 tRNA binding surface [nucleotide binding]; other site 373903004315 T-box leader 373903004316 Oligomerisation domain; Region: Oligomerisation; cl00519 373903004317 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 373903004318 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 373903004319 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 373903004320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903004321 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 373903004322 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 373903004323 active site 373903004324 (T/H)XGH motif; other site 373903004325 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 373903004326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903004327 putative substrate translocation pore; other site 373903004328 Phospholipid methyltransferase; Region: PEMT; cl00763 373903004329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373903004330 Coenzyme A binding pocket [chemical binding]; other site 373903004331 Putative cyclase; Region: Cyclase; cl00814 373903004332 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 373903004333 GTPase RsgA; Reviewed; Region: PRK01889 373903004334 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373903004335 RNA binding site [nucleotide binding]; other site 373903004336 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 373903004337 GTPase/Zn-binding domain interface [polypeptide binding]; other site 373903004338 GTP/Mg2+ binding site [chemical binding]; other site 373903004339 G4 box; other site 373903004340 G5 box; other site 373903004341 G1 box; other site 373903004342 Switch I region; other site 373903004343 G2 box; other site 373903004344 G3 box; other site 373903004345 Switch II region; other site 373903004346 Predicted acetyltransferase [General function prediction only]; Region: COG3153 373903004347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373903004348 Coenzyme A binding pocket [chemical binding]; other site 373903004349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903004350 Helix-turn-helix domains; Region: HTH; cl00088 373903004351 iron-sulfur cluster binding protein, putative; Region: TIGR00276 373903004352 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 373903004353 active site 373903004354 ATP binding site [chemical binding]; other site 373903004355 substrate binding site [chemical binding]; other site 373903004356 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373903004357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903004358 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 373903004359 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 373903004360 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 373903004361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903004362 FeS/SAM binding site; other site 373903004363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903004364 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 373903004365 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 373903004366 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903004367 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 373903004368 potential frameshift: common BLAST hit: gi|193215290|ref|YP_001996489.1| NADPH-dependent FMN reductase 373903004369 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 373903004370 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 373903004371 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004372 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 373903004373 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 373903004374 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 373903004375 Helix-turn-helix domains; Region: HTH; cl00088 373903004376 putative transposase OrfB; Reviewed; Region: PHA02517 373903004377 HTH-like domain; Region: HTH_21; pfam13276 373903004378 Integrase core domain; Region: rve; cl01316 373903004379 Integrase core domain; Region: rve_3; cl15866 373903004380 CAAX protease self-immunity; Region: Abi; cl00558 373903004381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903004382 S-adenosylmethionine binding site [chemical binding]; other site 373903004383 HEPN domain; Region: HEPN; cl00824 373903004384 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 373903004385 active site 373903004386 NTP binding site [chemical binding]; other site 373903004387 metal binding triad [ion binding]; metal-binding site 373903004388 antibiotic binding site [chemical binding]; other site 373903004389 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 373903004390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 373903004391 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 373903004392 Fe-S cluster binding site [ion binding]; other site 373903004393 pullulanase, type I; Region: pulA_typeI; TIGR02104 373903004394 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 373903004395 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 373903004396 Ca binding site [ion binding]; other site 373903004397 active site 373903004398 catalytic site [active] 373903004399 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 373903004400 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 373903004401 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903004402 putative peptidoglycan binding site; other site 373903004403 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 373903004404 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 373903004405 active site clefts [active] 373903004406 zinc binding site [ion binding]; other site 373903004407 dimer interface [polypeptide binding]; other site 373903004408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 373903004409 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 373903004410 nudix motif; other site 373903004411 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 373903004412 Predicted amidohydrolase [General function prediction only]; Region: COG0388 373903004413 active site 373903004414 catalytic triad [active] 373903004415 dimer interface [polypeptide binding]; other site 373903004416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004417 AAA domain; Region: AAA_18; pfam13238 373903004418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004419 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 373903004420 DNA interaction; other site 373903004421 Metal-binding active site; metal-binding site 373903004422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 373903004423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373903004424 active site 373903004425 metal binding site [ion binding]; metal-binding site 373903004426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373903004427 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903004428 Lamin Tail Domain; Region: LTD; pfam00932 373903004429 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 373903004430 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 373903004431 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004432 Walker A/P-loop; other site 373903004433 ATP binding site [chemical binding]; other site 373903004434 Q-loop/lid; other site 373903004435 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 373903004436 ABC transporter; Region: ABC_tran_2; pfam12848 373903004437 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 373903004438 ABC transporter; Region: ABC_tran_2; pfam12848 373903004439 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903004440 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 373903004441 GTPase CgtA; Reviewed; Region: obgE; PRK12297 373903004442 GTP1/OBG; Region: GTP1_OBG; pfam01018 373903004443 Obg GTPase; Region: Obg; cd01898 373903004444 G1 box; other site 373903004445 GTP/Mg2+ binding site [chemical binding]; other site 373903004446 Switch I region; other site 373903004447 G2 box; other site 373903004448 G3 box; other site 373903004449 Switch II region; other site 373903004450 G4 box; other site 373903004451 G5 box; other site 373903004452 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 373903004453 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 373903004454 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 373903004455 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 373903004456 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 373903004457 homodimer interface [polypeptide binding]; other site 373903004458 oligonucleotide binding site [chemical binding]; other site 373903004459 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 373903004460 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 373903004461 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 373903004462 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 373903004463 B12 binding site [chemical binding]; other site 373903004464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903004465 FeS/SAM binding site; other site 373903004466 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 373903004467 active site 373903004468 putative substrate binding region [chemical binding]; other site 373903004469 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 373903004470 Septum formation topological specificity factor MinE; Region: MinE; cl00538 373903004471 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 373903004472 Switch I; other site 373903004473 Switch II; other site 373903004474 septum formation inhibitor; Reviewed; Region: minC; PRK00513 373903004475 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 373903004476 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 373903004477 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373903004478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903004479 rod shape-determining protein MreD; Region: MreD; cl01087 373903004480 rod shape-determining protein MreC; Region: MreC; pfam04085 373903004481 rod shape-determining protein MreB; Provisional; Region: PRK13927 373903004482 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 373903004483 ATP binding site [chemical binding]; other site 373903004484 profilin binding site; other site 373903004485 hypothetical protein; Reviewed; Region: PRK00024 373903004486 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 373903004487 MPN+ (JAMM) motif; other site 373903004488 Zinc-binding site [ion binding]; other site 373903004489 Maf-like protein; Region: Maf; pfam02545 373903004490 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 373903004491 active site 373903004492 dimer interface [polypeptide binding]; other site 373903004493 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 373903004494 ApbE family; Region: ApbE; cl00643 373903004495 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 373903004496 ferredoxin; Validated; Region: PRK07118 373903004497 4Fe-4S binding domain; Region: Fer4; cl02805 373903004498 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 373903004499 4Fe-4S binding domain; Region: Fer4; cl02805 373903004500 4Fe-4S binding domain; Region: Fer4; cl02805 373903004501 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 373903004502 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 373903004503 FMN-binding domain; Region: FMN_bind; cl01081 373903004504 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 373903004505 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 373903004506 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 373903004507 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 373903004508 SLBB domain; Region: SLBB; pfam10531 373903004509 Sporulation related domain; Region: SPOR; cl10051 373903004510 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 373903004511 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373903004512 Divergent PAP2 family; Region: DUF212; cl00855 373903004513 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373903004514 active site 373903004515 NTP binding site [chemical binding]; other site 373903004516 metal binding triad [ion binding]; metal-binding site 373903004517 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 373903004518 cell division protein FtsA; Region: ftsA; TIGR01174 373903004519 Cell division protein FtsA; Region: FtsA; cl11496 373903004520 Cell division protein FtsA; Region: FtsA; cl11496 373903004521 transketolase; Reviewed; Region: PRK05899 373903004522 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 373903004523 TPP-binding site [chemical binding]; other site 373903004524 dimer interface [polypeptide binding]; other site 373903004525 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373903004526 PYR/PP interface [polypeptide binding]; other site 373903004527 dimer interface [polypeptide binding]; other site 373903004528 TPP binding site [chemical binding]; other site 373903004529 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373903004530 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 373903004531 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 373903004532 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 373903004533 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 373903004534 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 373903004535 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 373903004536 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373903004537 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 373903004538 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 373903004539 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 373903004540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903004541 S-adenosylmethionine binding site [chemical binding]; other site 373903004542 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 373903004543 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 373903004544 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 373903004545 catalytic residue [active] 373903004546 putative FPP diphosphate binding site; other site 373903004547 putative FPP binding hydrophobic cleft; other site 373903004548 dimer interface [polypeptide binding]; other site 373903004549 putative IPP diphosphate binding site; other site 373903004550 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373903004551 dimerization domain swap beta strand [polypeptide binding]; other site 373903004552 regulatory protein interface [polypeptide binding]; other site 373903004553 active site 373903004554 regulatory phosphorylation site [posttranslational modification]; other site 373903004555 EamA-like transporter family; Region: EamA; cl01037 373903004556 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903004557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903004558 DNA binding site [nucleotide binding] 373903004559 domain linker motif; other site 373903004560 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903004561 dimerization interface [polypeptide binding]; other site 373903004562 ligand binding site [chemical binding]; other site 373903004563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903004564 dimerization interface [polypeptide binding]; other site 373903004565 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903004566 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903004567 dimer interface [polypeptide binding]; other site 373903004568 putative CheW interface [polypeptide binding]; other site 373903004569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903004570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004571 dimer interface [polypeptide binding]; other site 373903004572 conserved gate region; other site 373903004573 putative PBP binding loops; other site 373903004574 ABC-ATPase subunit interface; other site 373903004575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 373903004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004577 dimer interface [polypeptide binding]; other site 373903004578 conserved gate region; other site 373903004579 putative PBP binding loops; other site 373903004580 ABC-ATPase subunit interface; other site 373903004581 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903004582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903004583 maltose phosphorylase; Provisional; Region: PRK13807 373903004584 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373903004585 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373903004586 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373903004587 UbiA prenyltransferase family; Region: UbiA; cl00337 373903004588 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 373903004589 MPT binding site; other site 373903004590 trimer interface [polypeptide binding]; other site 373903004591 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 373903004592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373903004593 active site 373903004594 HIGH motif; other site 373903004595 nucleotide binding site [chemical binding]; other site 373903004596 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373903004597 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 373903004598 active site 373903004599 KMSKS motif; other site 373903004600 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 373903004601 tRNA binding surface [nucleotide binding]; other site 373903004602 anticodon binding site; other site 373903004603 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 373903004604 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 373903004605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903004606 ATP binding site [chemical binding]; other site 373903004607 Mg2+ binding site [ion binding]; other site 373903004608 G-X-G motif; other site 373903004609 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373903004610 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 373903004611 putative dimer interface [polypeptide binding]; other site 373903004612 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 373903004613 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 373903004614 active site 373903004615 substrate binding site [chemical binding]; other site 373903004616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903004617 binding surface 373903004618 TPR motif; other site 373903004619 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 373903004620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903004621 ATP binding site [chemical binding]; other site 373903004622 putative Mg++ binding site [ion binding]; other site 373903004623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903004624 nucleotide binding region [chemical binding]; other site 373903004625 ATP-binding site [chemical binding]; other site 373903004626 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 373903004627 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373903004628 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373903004629 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 373903004630 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 373903004631 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373903004632 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 373903004633 active site 373903004634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903004635 dimerization interface [polypeptide binding]; other site 373903004636 putative DNA binding site [nucleotide binding]; other site 373903004637 putative Zn2+ binding site [ion binding]; other site 373903004638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903004639 Helix-turn-helix domains; Region: HTH; cl00088 373903004640 Predicted permease; Region: DUF318; pfam03773 373903004641 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 373903004642 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903004643 trehalose synthase; Region: treS_nterm; TIGR02456 373903004644 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 373903004645 Ca binding site [ion binding]; other site 373903004646 active site 373903004647 catalytic site [active] 373903004648 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 373903004649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 373903004650 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 373903004651 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 373903004652 Walker A/P-loop; other site 373903004653 ATP binding site [chemical binding]; other site 373903004654 Q-loop/lid; other site 373903004655 ABC transporter signature motif; other site 373903004656 Walker B; other site 373903004657 D-loop; other site 373903004658 H-loop/switch region; other site 373903004659 NMT1-like family; Region: NMT1_2; cl15260 373903004660 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 373903004661 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 373903004662 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373903004663 inhibitor-cofactor binding pocket; inhibition site 373903004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903004665 catalytic residue [active] 373903004666 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 373903004667 Peptidase family U32; Region: Peptidase_U32; cl03113 373903004668 Peptidase family U32; Region: Peptidase_U32; cl03113 373903004669 aromatic acid decarboxylase; Validated; Region: PRK05920 373903004670 Flavoprotein; Region: Flavoprotein; cl08021 373903004671 UbiA prenyltransferase family; Region: UbiA; cl00337 373903004672 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 373903004673 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 373903004674 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373903004675 substrate binding pocket [chemical binding]; other site 373903004676 chain length determination region; other site 373903004677 substrate-Mg2+ binding site; other site 373903004678 catalytic residues [active] 373903004679 aspartate-rich region 1; other site 373903004680 active site lid residues [active] 373903004681 aspartate-rich region 2; other site 373903004682 ApbE family; Region: ApbE; cl00643 373903004683 FMN-binding domain; Region: FMN_bind; cl01081 373903004684 FMN-binding domain; Region: FMN_bind; cl01081 373903004685 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 373903004686 DoxX; Region: DoxX; cl00976 373903004687 GAF domain; Region: GAF; cl15785 373903004688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373903004689 metal binding site [ion binding]; metal-binding site 373903004690 active site 373903004691 I-site; other site 373903004692 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 373903004693 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 373903004694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903004695 S-adenosylmethionine binding site [chemical binding]; other site 373903004696 Predicted GTPase [General function prediction only]; Region: COG0218 373903004697 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 373903004698 G1 box; other site 373903004699 GTP/Mg2+ binding site [chemical binding]; other site 373903004700 Switch I region; other site 373903004701 G2 box; other site 373903004702 G3 box; other site 373903004703 Switch II region; other site 373903004704 G4 box; other site 373903004705 G5 box; other site 373903004706 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 373903004707 Found in ATP-dependent protease La (LON); Region: LON; smart00464 373903004708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903004709 Walker A motif; other site 373903004710 ATP binding site [chemical binding]; other site 373903004711 Walker B motif; other site 373903004712 arginine finger; other site 373903004713 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903004714 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 373903004715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903004716 Walker A motif; other site 373903004717 ATP binding site [chemical binding]; other site 373903004718 Walker B motif; other site 373903004719 arginine finger; other site 373903004720 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903004721 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 373903004722 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 373903004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903004724 Walker A motif; other site 373903004725 ATP binding site [chemical binding]; other site 373903004726 Walker B motif; other site 373903004727 arginine finger; other site 373903004728 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 373903004729 Clp protease; Region: CLP_protease; pfam00574 373903004730 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373903004731 oligomer interface [polypeptide binding]; other site 373903004732 active site residues [active] 373903004733 trigger factor; Provisional; Region: tig; PRK01490 373903004734 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 373903004735 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 373903004736 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373903004737 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373903004738 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373903004739 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373903004740 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373903004741 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373903004742 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373903004743 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 373903004744 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 373903004745 potential frameshift: common BLAST hit: gi|187934291|ref|YP_001886240.1| peptidase, S41 family 373903004746 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 373903004747 Active site serine [active] 373903004748 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 373903004749 Ligand binding site; other site 373903004750 Putative Catalytic site; other site 373903004751 DXD motif; other site 373903004752 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 373903004753 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 373903004754 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 373903004755 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 373903004756 NifU-like domain; Region: NifU; cl00484 373903004757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903004758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004759 dimer interface [polypeptide binding]; other site 373903004760 conserved gate region; other site 373903004761 putative PBP binding loops; other site 373903004762 ABC-ATPase subunit interface; other site 373903004763 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 373903004764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004765 dimer interface [polypeptide binding]; other site 373903004766 conserved gate region; other site 373903004767 putative PBP binding loops; other site 373903004768 ABC-ATPase subunit interface; other site 373903004769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903004770 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 373903004771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903004772 DNA-binding site [nucleotide binding]; DNA binding site 373903004773 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 373903004774 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903004775 ligand binding site [chemical binding]; other site 373903004776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903004777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373903004778 putative substrate translocation pore; other site 373903004779 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373903004780 catalytic residues [active] 373903004781 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 373903004782 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 373903004783 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 373903004784 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 373903004785 RNA binding site [nucleotide binding]; other site 373903004786 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 373903004787 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 373903004788 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 373903004789 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 373903004790 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 373903004791 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 373903004792 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 373903004793 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 373903004794 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 373903004795 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 373903004796 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 373903004797 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 373903004798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004799 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 373903004800 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 373903004801 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 373903004802 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 373903004803 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 373903004804 Predicted transcriptional regulator [Transcription]; Region: COG2378 373903004805 Helix-turn-helix domains; Region: HTH; cl00088 373903004806 WYL domain; Region: WYL; cl14852 373903004807 Protein of unknown function (DUF964); Region: DUF964; cl01483 373903004808 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 373903004809 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373903004810 HSP70 interaction site [polypeptide binding]; other site 373903004811 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 373903004812 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 373903004813 Walker A/P-loop; other site 373903004814 ATP binding site [chemical binding]; other site 373903004815 Q-loop/lid; other site 373903004816 ABC transporter signature motif; other site 373903004817 Walker B; other site 373903004818 D-loop; other site 373903004819 H-loop/switch region; other site 373903004820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004822 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 373903004823 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373903004824 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 373903004825 NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit; Region: nqrF; TIGR01941 373903004826 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 373903004827 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 373903004828 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 373903004829 B12 binding site [chemical binding]; other site 373903004830 cobalt ligand [ion binding]; other site 373903004831 Sensory domain found in PocR; Region: PocR; pfam10114 373903004832 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 373903004833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903004834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373903004835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903004836 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 373903004837 active site 373903004838 dimerization interface [polypeptide binding]; other site 373903004839 ribonuclease PH; Reviewed; Region: rph; PRK00173 373903004840 Ribonuclease PH; Region: RNase_PH_bact; cd11362 373903004841 hexamer interface [polypeptide binding]; other site 373903004842 active site 373903004843 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 373903004844 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 373903004845 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 373903004846 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 373903004847 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 373903004848 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 373903004849 dimer interface [polypeptide binding]; other site 373903004850 active site 373903004851 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 373903004852 substrate binding site [chemical binding]; other site 373903004853 B12 cofactor binding site [chemical binding]; other site 373903004854 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 373903004855 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 373903004856 MutL protein; Region: MutL; pfam13941 373903004857 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5...; Region: Glm_B12_BD; cd02072 373903004858 B12 binding site [chemical binding]; other site 373903004859 heterodimer interface [polypeptide binding]; other site 373903004860 cobalt ligand [ion binding]; other site 373903004861 Predicted transcriptional regulators [Transcription]; Region: COG1725 373903004862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903004863 DNA-binding site [nucleotide binding]; DNA binding site 373903004864 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 373903004865 Sporulation and spore germination; Region: Germane; cl11253 373903004866 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 373903004867 AMIN domain; Region: AMIN; pfam11741 373903004868 AMIN domain; Region: AMIN; pfam11741 373903004869 AMIN domain; Region: AMIN; pfam11741 373903004870 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373903004871 active site 373903004872 metal binding site [ion binding]; metal-binding site 373903004873 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 373903004874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903004875 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 373903004876 Protein of unknown function (DUF327); Region: DUF327; cl00753 373903004877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004878 dimer interface [polypeptide binding]; other site 373903004879 conserved gate region; other site 373903004880 putative PBP binding loops; other site 373903004881 ABC-ATPase subunit interface; other site 373903004882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903004883 dimer interface [polypeptide binding]; other site 373903004884 conserved gate region; other site 373903004885 putative PBP binding loops; other site 373903004886 ABC-ATPase subunit interface; other site 373903004887 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903004888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903004889 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 373903004890 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373903004891 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 373903004892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903004893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903004894 DNA binding site [nucleotide binding] 373903004895 domain linker motif; other site 373903004896 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903004897 dimerization interface [polypeptide binding]; other site 373903004898 ligand binding site [chemical binding]; other site 373903004899 Protein of unknown function (DUF503); Region: DUF503; cl00669 373903004900 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 373903004901 diiron binding motif [ion binding]; other site 373903004902 PGDYG protein; Region: PGDYG; pfam14083 373903004903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373903004904 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903004905 Q-loop/lid; other site 373903004906 ABC transporter signature motif; other site 373903004907 Walker B; other site 373903004908 D-loop; other site 373903004909 H-loop/switch region; other site 373903004910 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 373903004911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903004912 Walker A motif; other site 373903004913 ATP binding site [chemical binding]; other site 373903004914 Walker B motif; other site 373903004915 arginine finger; other site 373903004916 C2 domain; Region: C2; cl14603 373903004917 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 373903004918 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 373903004919 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 373903004920 SmpB-tmRNA interface; other site 373903004921 ribonuclease R; Region: RNase_R; TIGR02063 373903004922 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373903004923 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373903004924 RNB domain; Region: RNB; pfam00773 373903004925 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 373903004926 RNA binding site [nucleotide binding]; other site 373903004927 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 373903004928 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 373903004929 CoenzymeA binding site [chemical binding]; other site 373903004930 subunit interaction site [polypeptide binding]; other site 373903004931 PHB binding site; other site 373903004932 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 373903004933 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 373903004934 Preprotein translocase SecG subunit; Region: SecG; cl09123 373903004935 enolase; Provisional; Region: eno; PRK00077 373903004936 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 373903004937 dimer interface [polypeptide binding]; other site 373903004938 metal binding site [ion binding]; metal-binding site 373903004939 substrate binding pocket [chemical binding]; other site 373903004940 Sulfatase; Region: Sulfatase; cl10460 373903004941 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 373903004942 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 373903004943 substrate binding site [chemical binding]; other site 373903004944 dimer interface [polypeptide binding]; other site 373903004945 catalytic triad [active] 373903004946 Phosphoglycerate kinase; Region: PGK; pfam00162 373903004947 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 373903004948 substrate binding site [chemical binding]; other site 373903004949 hinge regions; other site 373903004950 ADP binding site [chemical binding]; other site 373903004951 catalytic site [active] 373903004952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903004953 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 373903004954 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 373903004955 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 373903004956 Predicted transcriptional regulator [Transcription]; Region: COG3388 373903004957 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 373903004958 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 373903004959 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 373903004960 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 373903004961 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 373903004962 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 373903004963 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 373903004964 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 373903004965 phosphate binding site [ion binding]; other site 373903004966 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 373903004967 putative substrate binding pocket [chemical binding]; other site 373903004968 dimer interface [polypeptide binding]; other site 373903004969 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 373903004970 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 373903004971 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 373903004972 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 373903004973 putative hydrolase; Validated; Region: PRK09248 373903004974 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 373903004975 substrate binding pocket [chemical binding]; other site 373903004976 substrate-Mg2+ binding site; other site 373903004977 aspartate-rich region 1; other site 373903004978 aspartate-rich region 2; other site 373903004979 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 373903004980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903004981 Zn2+ binding site [ion binding]; other site 373903004982 Mg2+ binding site [ion binding]; other site 373903004983 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 373903004984 ligand binding site [chemical binding]; other site 373903004985 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 373903004986 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 373903004987 putative FMN binding site [chemical binding]; other site 373903004988 Uncharacterized conserved protein [Function unknown]; Region: COG3461 373903004989 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 373903004990 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 373903004991 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 373903004992 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 373903004993 active site 373903004994 Substrate binding site; other site 373903004995 Mg++ binding site; other site 373903004996 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373903004997 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 373903004998 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 373903004999 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 373903005000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903005001 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373903005002 Uncharacterized conserved protein [Function unknown]; Region: COG1543 373903005003 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 373903005004 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 373903005005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 373903005006 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 373903005007 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 373903005008 putative ligand binding site [chemical binding]; other site 373903005009 HPr kinase/phosphorylase; Provisional; Region: PRK05428 373903005010 DRTGG domain; Region: DRTGG; cl12147 373903005011 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 373903005012 Hpr binding site; other site 373903005013 active site 373903005014 homohexamer subunit interaction site [polypeptide binding]; other site 373903005015 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 373903005016 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903005017 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903005018 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 373903005019 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 373903005020 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 373903005021 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 373903005022 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 373903005023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903005024 FeS/SAM binding site; other site 373903005025 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 373903005026 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 373903005027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903005028 active site 373903005029 motif I; other site 373903005030 motif II; other site 373903005031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903005032 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 373903005033 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 373903005034 dimer interface [polypeptide binding]; other site 373903005035 glycine-pyridoxal phosphate binding site [chemical binding]; other site 373903005036 active site 373903005037 folate binding site [chemical binding]; other site 373903005038 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 373903005039 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 373903005040 NAD binding site [chemical binding]; other site 373903005041 dimer interface [polypeptide binding]; other site 373903005042 substrate binding site [chemical binding]; other site 373903005043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373903005044 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 373903005045 4Fe-4S binding domain; Region: Fer4; cl02805 373903005046 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 373903005047 homodimer interface [polypeptide binding]; other site 373903005048 maltodextrin glucosidase; Provisional; Region: PRK10785 373903005049 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 373903005050 active site 373903005051 homodimer interface [polypeptide binding]; other site 373903005052 catalytic site [active] 373903005053 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 373903005054 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 373903005055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005056 dimer interface [polypeptide binding]; other site 373903005057 conserved gate region; other site 373903005058 putative PBP binding loops; other site 373903005059 ABC-ATPase subunit interface; other site 373903005060 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 373903005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005062 dimer interface [polypeptide binding]; other site 373903005063 conserved gate region; other site 373903005064 putative PBP binding loops; other site 373903005065 ABC-ATPase subunit interface; other site 373903005066 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 373903005067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903005068 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903005069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903005070 DNA binding site [nucleotide binding] 373903005071 domain linker motif; other site 373903005072 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903005073 dimerization interface [polypeptide binding]; other site 373903005074 ligand binding site [chemical binding]; other site 373903005075 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 373903005076 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 373903005077 GIY-YIG motif/motif A; other site 373903005078 active site 373903005079 catalytic site [active] 373903005080 putative DNA binding site [nucleotide binding]; other site 373903005081 metal binding site [ion binding]; metal-binding site 373903005082 UvrB/uvrC motif; Region: UVR; pfam02151 373903005083 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 373903005084 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 373903005085 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 373903005086 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 373903005087 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 373903005088 excinuclease ABC subunit B; Provisional; Region: PRK05298 373903005089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903005090 ATP binding site [chemical binding]; other site 373903005091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903005092 nucleotide binding region [chemical binding]; other site 373903005093 ATP-binding site [chemical binding]; other site 373903005094 Ultra-violet resistance protein B; Region: UvrB; pfam12344 373903005095 UvrB/uvrC motif; Region: UVR; pfam02151 373903005096 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 373903005097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903005098 NlpC/P60 family; Region: NLPC_P60; cl11438 373903005099 Putative cyclase; Region: Cyclase; cl00814 373903005100 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 373903005101 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 373903005102 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 373903005103 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 373903005104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903005105 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 373903005106 putative subunit interface; other site 373903005107 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 373903005108 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 373903005109 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 373903005110 active site 373903005111 FMN binding site [chemical binding]; other site 373903005112 substrate binding site [chemical binding]; other site 373903005113 3Fe-4S cluster binding site [ion binding]; other site 373903005114 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 373903005115 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 373903005116 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 373903005117 putative active site [active] 373903005118 Transcriptional regulator [Transcription]; Region: IclR; COG1414 373903005119 Helix-turn-helix domains; Region: HTH; cl00088 373903005120 Bacterial transcriptional regulator; Region: IclR; pfam01614 373903005121 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 373903005122 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 373903005123 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 373903005124 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 373903005125 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 373903005126 putative L-serine binding site [chemical binding]; other site 373903005127 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 373903005128 C-terminal peptidase (prc); Region: prc; TIGR00225 373903005129 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373903005130 protein binding site [polypeptide binding]; other site 373903005131 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 373903005132 Catalytic dyad [active] 373903005133 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 373903005134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005135 Walker A/P-loop; other site 373903005136 ATP binding site [chemical binding]; other site 373903005137 Q-loop/lid; other site 373903005138 ABC transporter signature motif; other site 373903005139 Walker B; other site 373903005140 D-loop; other site 373903005141 H-loop/switch region; other site 373903005142 Uncharacterized conserved protein [Function unknown]; Region: COG1284 373903005143 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 373903005144 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 373903005145 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 373903005146 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373903005147 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 373903005148 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 373903005149 peptide chain release factor 2; Provisional; Region: PRK05589 373903005150 RF-1 domain; Region: RF-1; cl02875 373903005151 RF-1 domain; Region: RF-1; cl02875 373903005152 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 373903005153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005154 ATP binding site [chemical binding]; other site 373903005155 putative Mg++ binding site [ion binding]; other site 373903005156 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 373903005157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005158 SEC-C motif; Region: SEC-C; pfam02810 373903005159 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 373903005160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 373903005161 phosphate binding site [ion binding]; other site 373903005162 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 373903005163 30S subunit binding site; other site 373903005164 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 373903005165 DNA-binding site [nucleotide binding]; DNA binding site 373903005166 RNA-binding motif; other site 373903005167 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 373903005168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903005169 active site 373903005170 RNA polymerase factor sigma-70; Validated; Region: PRK08295 373903005171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903005172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903005173 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373903005174 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 373903005175 active site 373903005176 nucleotide binding site [chemical binding]; other site 373903005177 HIGH motif; other site 373903005178 KMSKS motif; other site 373903005179 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903005180 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 373903005181 putative ribose interaction site [chemical binding]; other site 373903005182 putative ADP binding site [chemical binding]; other site 373903005183 Sporulation related domain; Region: SPOR; cl10051 373903005184 Stage II sporulation protein; Region: SpoIID; pfam08486 373903005185 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 373903005186 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373903005187 Rod binding protein; Region: Rod-binding; cl01626 373903005188 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 373903005189 Flagellar P-ring protein; Region: FlgI; pfam02119 373903005190 Flagellar L-ring protein; Region: FlgH; cl00905 373903005191 SAF-like; Region: SAF_2; pfam13144 373903005192 SAF domain; Region: SAF; cl00555 373903005193 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 373903005194 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 373903005195 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 373903005196 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 373903005197 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 373903005198 YceG-like family; Region: YceG; pfam02618 373903005199 Protein of unknown function (DUF342); Region: DUF342; pfam03961 373903005200 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 373903005201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903005202 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373903005203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903005204 DNA binding residues [nucleotide binding] 373903005205 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 373903005206 Flagellar protein YcgR; Region: YcgR_2; pfam12945 373903005207 PilZ domain; Region: PilZ; cl01260 373903005208 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 373903005209 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 373903005210 P-loop; other site 373903005211 ADP binding residues [chemical binding]; other site 373903005212 Switch I; other site 373903005213 Switch II; other site 373903005214 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 373903005215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005216 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 373903005217 FHIPEP family; Region: FHIPEP; pfam00771 373903005218 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 373903005219 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 373903005220 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 373903005221 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 373903005222 FliP family; Region: FliP; cl00593 373903005223 flagellar motor switch protein; Validated; Region: PRK08119 373903005224 Chemotaxis phosphatase CheX; Region: CheX; cl15816 373903005225 Chemotaxis phosphatase CheX; Region: CheX; cl15816 373903005226 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 373903005227 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 373903005228 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 373903005229 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 373903005230 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 373903005231 flagellar motor protein MotS; Reviewed; Region: PRK06925 373903005232 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 373903005233 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373903005234 ligand binding site [chemical binding]; other site 373903005235 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 373903005236 Flagellar protein (FlbD); Region: FlbD; cl00683 373903005237 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 373903005238 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 373903005239 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 373903005240 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 373903005241 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 373903005242 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 373903005243 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 373903005244 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 373903005245 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 373903005246 MgtE intracellular N domain; Region: MgtE_N; cl15244 373903005247 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 373903005248 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 373903005249 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 373903005250 Walker A motif/ATP binding site; other site 373903005251 Walker B motif; other site 373903005252 Plant ATP synthase F0; Region: YMF19; cl07975 373903005253 Flagellar assembly protein FliH; Region: FliH; pfam02108 373903005254 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 373903005255 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 373903005256 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 373903005257 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 373903005258 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 373903005259 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 373903005260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 373903005261 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 373903005262 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 373903005263 Response regulator receiver domain; Region: Response_reg; pfam00072 373903005264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903005265 active site 373903005266 phosphorylation site [posttranslational modification] 373903005267 intermolecular recognition site; other site 373903005268 dimerization interface [polypeptide binding]; other site 373903005269 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 373903005270 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 373903005271 active site 373903005272 homodimer interface [polypeptide binding]; other site 373903005273 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 373903005274 NeuB family; Region: NeuB; cl00496 373903005275 SAF domain; Region: SAF; cl00555 373903005276 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 373903005277 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 373903005278 putative trimer interface [polypeptide binding]; other site 373903005279 putative CoA binding site [chemical binding]; other site 373903005280 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 373903005281 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373903005282 inhibitor-cofactor binding pocket; inhibition site 373903005283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903005284 catalytic residue [active] 373903005285 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373903005286 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 373903005287 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 373903005288 NAD(P) binding site [chemical binding]; other site 373903005289 homodimer interface [polypeptide binding]; other site 373903005290 substrate binding site [chemical binding]; other site 373903005291 active site 373903005292 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 373903005293 ligand binding site; other site 373903005294 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 373903005295 NeuB family; Region: NeuB; cl00496 373903005296 SAF domain; Region: SAF; cl00555 373903005297 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 373903005298 Flagellar protein FliS; Region: FliS; cl00654 373903005299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 373903005300 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 373903005301 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 373903005302 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 373903005303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 373903005304 FlaG protein; Region: FlaG; cl00591 373903005305 flagellin; Provisional; Region: PRK12804 373903005306 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 373903005307 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 373903005308 Global regulator protein family; Region: CsrA; cl00670 373903005309 FliW protein; Region: FliW; cl00740 373903005310 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 373903005311 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 373903005312 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 373903005313 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 373903005314 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 373903005315 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 373903005316 FlgN protein; Region: FlgN; cl09176 373903005317 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 373903005318 flagellar operon protein TIGR03826; Region: YvyF 373903005319 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 373903005320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903005321 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 373903005322 putative ADP-binding pocket [chemical binding]; other site 373903005323 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373903005324 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373903005325 putative active site [active] 373903005326 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 373903005327 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373903005328 inhibitor-cofactor binding pocket; inhibition site 373903005329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903005330 catalytic residue [active] 373903005331 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 373903005332 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 373903005333 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 373903005334 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 373903005335 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 373903005336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903005337 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 373903005338 Sulfatase; Region: Sulfatase; cl10460 373903005339 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 373903005340 Sulfatase; Region: Sulfatase; cl10460 373903005341 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 373903005342 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 373903005343 active site 373903005344 FMN binding site [chemical binding]; other site 373903005345 substrate binding site [chemical binding]; other site 373903005346 3Fe-4S cluster binding site [ion binding]; other site 373903005347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903005348 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 373903005349 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 373903005350 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 373903005351 NADP binding site [chemical binding]; other site 373903005352 active site 373903005353 putative substrate binding site [chemical binding]; other site 373903005354 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 373903005355 active site 373903005356 tetramer interface; other site 373903005357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903005358 Zn2+ binding site [ion binding]; other site 373903005359 Mg2+ binding site [ion binding]; other site 373903005360 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 373903005361 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 373903005362 active site 373903005363 substrate binding site [chemical binding]; other site 373903005364 metal binding site [ion binding]; metal-binding site 373903005365 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 373903005366 S-layer homology domain; Region: SLH; pfam00395 373903005367 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 373903005368 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 373903005369 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 373903005370 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 373903005371 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 373903005372 Protein of unknown function (DUF1633); Region: DUF1633; pfam07794 373903005373 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 373903005374 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373903005375 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 373903005376 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 373903005377 Walker A/P-loop; other site 373903005378 ATP binding site [chemical binding]; other site 373903005379 Q-loop/lid; other site 373903005380 ABC transporter signature motif; other site 373903005381 Walker B; other site 373903005382 D-loop; other site 373903005383 H-loop/switch region; other site 373903005384 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 373903005385 OstA-like protein; Region: OstA; cl00844 373903005386 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 373903005387 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 373903005388 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 373903005389 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 373903005390 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 373903005391 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 373903005392 active site 373903005393 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 373903005394 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 373903005395 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 373903005396 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373903005397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005398 Walker A/P-loop; other site 373903005399 ATP binding site [chemical binding]; other site 373903005400 Q-loop/lid; other site 373903005401 ABC transporter signature motif; other site 373903005402 Walker B; other site 373903005403 D-loop; other site 373903005404 H-loop/switch region; other site 373903005405 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 373903005406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005407 dimer interface [polypeptide binding]; other site 373903005408 ABC-ATPase subunit interface; other site 373903005409 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 373903005410 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 373903005411 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373903005412 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 373903005413 Protein of unknown function, DUF481; Region: DUF481; cl01213 373903005414 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 373903005415 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 373903005416 active site 373903005417 catalytic triad [active] 373903005418 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 373903005419 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 373903005420 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 373903005421 trimer interface [polypeptide binding]; other site 373903005422 active site 373903005423 UDP-GlcNAc binding site [chemical binding]; other site 373903005424 lipid binding site [chemical binding]; lipid-binding site 373903005425 periplasmic chaperone; Provisional; Region: PRK10780 373903005426 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 373903005427 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 373903005428 periplasmic chaperone; Provisional; Region: PRK10780 373903005429 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 373903005430 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 373903005431 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 373903005432 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 373903005433 Surface antigen; Region: Bac_surface_Ag; cl03097 373903005434 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 373903005435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373903005436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373903005437 DNA binding residues [nucleotide binding] 373903005438 AsmA-like C-terminal region; Region: AsmA_2; cl15864 373903005439 Family of unknown function (DUF490); Region: DUF490; pfam04357 373903005440 AsmA-like C-terminal region; Region: AsmA_2; cl15864 373903005441 Family of unknown function (DUF490); Region: DUF490; pfam04357 373903005442 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 373903005443 rod shape-determining protein Mbl; Provisional; Region: PRK13928 373903005444 Cell division protein FtsA; Region: FtsA; cl11496 373903005445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903005446 Peptidase family M23; Region: Peptidase_M23; pfam01551 373903005447 stage II sporulation protein D; Region: spore_II_D; TIGR02870 373903005448 Stage II sporulation protein; Region: SpoIID; pfam08486 373903005449 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 373903005450 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 373903005451 hinge; other site 373903005452 active site 373903005453 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 373903005454 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 373903005455 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 373903005456 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 373903005457 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 373903005458 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 373903005459 alpha subunit interaction interface [polypeptide binding]; other site 373903005460 Walker A motif; other site 373903005461 ATP binding site [chemical binding]; other site 373903005462 Walker B motif; other site 373903005463 inhibitor binding site; inhibition site 373903005464 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373903005465 ATP synthase; Region: ATP-synt; cl00365 373903005466 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 373903005467 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 373903005468 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 373903005469 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 373903005470 beta subunit interaction interface [polypeptide binding]; other site 373903005471 Walker A motif; other site 373903005472 ATP binding site [chemical binding]; other site 373903005473 Walker B motif; other site 373903005474 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373903005475 Plant ATP synthase F0; Region: YMF19; cl07975 373903005476 Plant ATP synthase F0; Region: YMF19; cl07975 373903005477 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 373903005478 ATP synthase subunit C; Region: ATP-synt_C; cl00466 373903005479 ATP synthase A chain; Region: ATP-synt_A; cl00413 373903005480 ATP synthase I chain; Region: ATP_synt_I; cl09170 373903005481 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 373903005482 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 373903005483 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 373903005484 active site 373903005485 homodimer interface [polypeptide binding]; other site 373903005486 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 373903005487 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 373903005488 Mg++ binding site [ion binding]; other site 373903005489 putative catalytic motif [active] 373903005490 substrate binding site [chemical binding]; other site 373903005491 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903005492 active site 373903005493 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373903005494 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 373903005495 active site 373903005496 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 373903005497 Predicted membrane protein [Function unknown]; Region: COG1971 373903005498 Domain of unknown function DUF; Region: DUF204; pfam02659 373903005499 Domain of unknown function DUF; Region: DUF204; pfam02659 373903005500 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 373903005501 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 373903005502 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 373903005503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903005504 S-adenosylmethionine binding site [chemical binding]; other site 373903005505 peptide chain release factor 1; Validated; Region: prfA; PRK00591 373903005506 RF-1 domain; Region: RF-1; cl02875 373903005507 RF-1 domain; Region: RF-1; cl02875 373903005508 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 373903005509 thymidine kinase; Provisional; Region: PRK04296 373903005510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005511 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 373903005512 transcription termination factor Rho; Provisional; Region: rho; PRK09376 373903005513 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 373903005514 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 373903005515 RNA binding site [nucleotide binding]; other site 373903005516 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 373903005517 multimer interface [polypeptide binding]; other site 373903005518 Walker A motif; other site 373903005519 ATP binding site [chemical binding]; other site 373903005520 Walker B motif; other site 373903005521 hypothetical protein; Provisional; Region: PRK08185 373903005522 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 373903005523 intersubunit interface [polypeptide binding]; other site 373903005524 active site 373903005525 zinc binding site [ion binding]; other site 373903005526 Na+ binding site [ion binding]; other site 373903005527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903005528 motif II; other site 373903005529 CTP synthetase; Validated; Region: pyrG; PRK05380 373903005530 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 373903005531 Catalytic site [active] 373903005532 active site 373903005533 UTP binding site [chemical binding]; other site 373903005534 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 373903005535 active site 373903005536 putative oxyanion hole; other site 373903005537 catalytic triad [active] 373903005538 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 373903005539 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 373903005540 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 373903005541 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 373903005542 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 373903005543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005544 Walker A/P-loop; other site 373903005545 ATP binding site [chemical binding]; other site 373903005546 Q-loop/lid; other site 373903005547 ABC transporter signature motif; other site 373903005548 Walker B; other site 373903005549 D-loop; other site 373903005550 H-loop/switch region; other site 373903005551 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373903005552 catalytic residues [active] 373903005553 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 373903005554 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373903005555 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 373903005556 catalytic residues [active] 373903005557 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 373903005558 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 373903005559 oligomer interface [polypeptide binding]; other site 373903005560 putative active site [active] 373903005561 metal binding site [ion binding]; metal-binding site 373903005562 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 373903005563 TFIIA subunit interface [polypeptide binding]; other site 373903005564 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 373903005565 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373903005566 ligand binding site [chemical binding]; other site 373903005567 flexible hinge region; other site 373903005568 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373903005569 putative switch regulator; other site 373903005570 non-specific DNA interactions [nucleotide binding]; other site 373903005571 DNA binding site [nucleotide binding] 373903005572 sequence specific DNA binding site [nucleotide binding]; other site 373903005573 putative cAMP binding site [chemical binding]; other site 373903005574 FecR protein; Region: FecR; pfam04773 373903005575 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 373903005576 CHASE2 domain; Region: CHASE2; cl01732 373903005577 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 373903005578 cyclase homology domain; Region: CHD; cd07302 373903005579 nucleotidyl binding site; other site 373903005580 metal binding site [ion binding]; metal-binding site 373903005581 dimer interface [polypeptide binding]; other site 373903005582 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 373903005583 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 373903005584 catalytic residues [active] 373903005585 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 373903005586 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 373903005587 putative ADP-binding pocket [chemical binding]; other site 373903005588 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903005589 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 373903005590 substrate binding site [chemical binding]; other site 373903005591 ATP binding site [chemical binding]; other site 373903005592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903005593 DNA binding site [nucleotide binding] 373903005594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903005595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903005596 DNA binding site [nucleotide binding] 373903005597 domain linker motif; other site 373903005598 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903005599 ligand binding site [chemical binding]; other site 373903005600 dimerization interface [polypeptide binding]; other site 373903005601 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 373903005602 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 373903005603 active site 373903005604 Na/Ca binding site [ion binding]; other site 373903005605 catalytic site [active] 373903005606 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 373903005607 glycogen binding site [chemical binding]; other site 373903005608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903005609 S-layer homology domain; Region: SLH; pfam00395 373903005610 hybrid cluster protein; Provisional; Region: PRK05290 373903005611 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373903005612 ACS interaction site; other site 373903005613 CODH interaction site; other site 373903005614 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 373903005615 hybrid metal cluster; other site 373903005616 DNA damage checkpoint protein; Region: LCD1; pfam09798 373903005617 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 373903005618 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 373903005619 Walker A motif; other site 373903005620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373903005621 ABC-ATPase subunit interface; other site 373903005622 dimer interface [polypeptide binding]; other site 373903005623 putative PBP binding regions; other site 373903005624 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373903005625 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 373903005626 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 373903005627 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 373903005628 intersubunit interface [polypeptide binding]; other site 373903005629 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 373903005630 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 373903005631 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 373903005632 P loop nucleotide binding; other site 373903005633 switch II; other site 373903005634 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 373903005635 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 373903005636 P loop nucleotide binding; other site 373903005637 switch II; other site 373903005638 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 373903005639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903005640 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 373903005641 NMT1-like family; Region: NMT1_2; cl15260 373903005642 NMT1-like family; Region: NMT1_2; cl15260 373903005643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005644 dimer interface [polypeptide binding]; other site 373903005645 conserved gate region; other site 373903005646 ABC-ATPase subunit interface; other site 373903005647 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 373903005648 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 373903005649 Walker A/P-loop; other site 373903005650 ATP binding site [chemical binding]; other site 373903005651 Q-loop/lid; other site 373903005652 ABC transporter signature motif; other site 373903005653 Walker B; other site 373903005654 D-loop; other site 373903005655 H-loop/switch region; other site 373903005656 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 373903005657 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 373903005658 intersubunit interface [polypeptide binding]; other site 373903005659 active site 373903005660 Zn2+ binding site [ion binding]; other site 373903005661 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 373903005662 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 373903005663 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 373903005664 MatE; Region: MatE; cl10513 373903005665 MatE; Region: MatE; cl10513 373903005666 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 373903005667 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 373903005668 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903005669 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373903005670 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903005671 RHS Repeat; Region: RHS_repeat; cl11982 373903005672 RHS Repeat; Region: RHS_repeat; cl11982 373903005673 RHS Repeat; Region: RHS_repeat; cl11982 373903005674 RHS Repeat; Region: RHS_repeat; cl11982 373903005675 RHS Repeat; Region: RHS_repeat; cl11982 373903005676 RHS Repeat; Region: RHS_repeat; cl11982 373903005677 RHS Repeat; Region: RHS_repeat; cl11982 373903005678 RHS Repeat; Region: RHS_repeat; cl11982 373903005679 RHS Repeat; Region: RHS_repeat; cl11982 373903005680 RHS Repeat; Region: RHS_repeat; cl11982 373903005681 RHS Repeat; Region: RHS_repeat; cl11982 373903005682 RHS Repeat; Region: RHS_repeat; cl11982 373903005683 RHS Repeat; Region: RHS_repeat; cl11982 373903005684 RHS Repeat; Region: RHS_repeat; cl11982 373903005685 RHS Repeat; Region: RHS_repeat; cl11982 373903005686 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373903005687 RHS Repeat; Region: RHS_repeat; cl11982 373903005688 RHS Repeat; Region: RHS_repeat; cl11982 373903005689 RHS Repeat; Region: RHS_repeat; cl11982 373903005690 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373903005691 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903005692 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 373903005693 Secretin and TonB N terminus short domain; Region: STN; cl06624 373903005694 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 373903005695 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 373903005696 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 373903005697 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 373903005698 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 373903005699 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 373903005700 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 373903005701 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 373903005702 general secretion pathway protein F; Region: GspF; TIGR02120 373903005703 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 373903005704 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 373903005705 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 373903005706 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 373903005707 Walker A motif; other site 373903005708 ATP binding site [chemical binding]; other site 373903005709 Walker B motif; other site 373903005710 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 373903005711 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 373903005712 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 373903005713 active site 373903005714 Ca binding site [ion binding]; other site 373903005715 catalytic site [active] 373903005716 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 373903005717 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373903005718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005719 dimer interface [polypeptide binding]; other site 373903005720 conserved gate region; other site 373903005721 putative PBP binding loops; other site 373903005722 ABC-ATPase subunit interface; other site 373903005723 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373903005724 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 373903005725 Walker A/P-loop; other site 373903005726 ATP binding site [chemical binding]; other site 373903005727 Q-loop/lid; other site 373903005728 ABC transporter signature motif; other site 373903005729 Walker B; other site 373903005730 D-loop; other site 373903005731 H-loop/switch region; other site 373903005732 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373903005733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903005734 dimer interface [polypeptide binding]; other site 373903005735 conserved gate region; other site 373903005736 putative PBP binding loops; other site 373903005737 ABC-ATPase subunit interface; other site 373903005738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373903005739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 373903005740 substrate binding pocket [chemical binding]; other site 373903005741 membrane-bound complex binding site; other site 373903005742 hinge residues; other site 373903005743 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 373903005744 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373903005745 active site 373903005746 HIGH motif; other site 373903005747 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373903005748 active site 373903005749 KMSKS motif; other site 373903005750 FMN-binding domain; Region: FMN_bind; cl01081 373903005751 FMN-binding domain; Region: FMN_bind; cl01081 373903005752 GtrA-like protein; Region: GtrA; cl00971 373903005753 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 373903005754 active site 373903005755 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373903005756 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 373903005757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373903005758 active site 373903005759 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373903005760 O-Antigen ligase; Region: Wzy_C; cl04850 373903005761 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 373903005762 putative metal binding site; other site 373903005763 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373903005764 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373903005765 putative active site [active] 373903005766 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 373903005767 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 373903005768 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373903005769 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373903005770 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373903005771 putative active site [active] 373903005772 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 373903005773 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 373903005774 putative acyl-acceptor binding pocket; other site 373903005775 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 373903005776 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 373903005777 putative active site [active] 373903005778 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 373903005779 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373903005780 NeuB family; Region: NeuB; cl00496 373903005781 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 373903005782 Ligand binding site; other site 373903005783 oligomer interface; other site 373903005784 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 373903005785 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 373903005786 putative acyl-acceptor binding pocket; other site 373903005787 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 373903005788 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 373903005789 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 373903005790 Walker A/P-loop; other site 373903005791 ATP binding site [chemical binding]; other site 373903005792 Q-loop/lid; other site 373903005793 ABC transporter signature motif; other site 373903005794 Walker B; other site 373903005795 D-loop; other site 373903005796 H-loop/switch region; other site 373903005797 HutP; Region: HutP; cl07944 373903005798 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 373903005799 homodimer interface [polypeptide binding]; other site 373903005800 Walker A motif; other site 373903005801 ATP binding site [chemical binding]; other site 373903005802 hydroxycobalamin binding site [chemical binding]; other site 373903005803 Walker B motif; other site 373903005804 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 373903005805 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 373903005806 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 373903005807 cobalamin binding residues [chemical binding]; other site 373903005808 putative BtuC binding residues; other site 373903005809 dimer interface [polypeptide binding]; other site 373903005810 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 373903005811 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 373903005812 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 373903005813 MoxR-like ATPases [General function prediction only]; Region: COG0714 373903005814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903005815 Walker A motif; other site 373903005816 ATP binding site [chemical binding]; other site 373903005817 Walker B motif; other site 373903005818 arginine finger; other site 373903005819 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 373903005820 NAD synthase; Region: NAD_synthase; pfam02540 373903005821 homodimer interface [polypeptide binding]; other site 373903005822 NAD binding pocket [chemical binding]; other site 373903005823 ATP binding pocket [chemical binding]; other site 373903005824 Mg binding site [ion binding]; other site 373903005825 active-site loop [active] 373903005826 Protein kinase domain; Region: Pkinase; pfam00069 373903005827 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373903005828 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 373903005829 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 373903005830 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 373903005831 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 373903005832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 373903005833 active site 373903005834 dimer interface [polypeptide binding]; other site 373903005835 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 373903005836 dimer interface [polypeptide binding]; other site 373903005837 active site 373903005838 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 373903005839 Rubrerythrin [Energy production and conversion]; Region: COG1592 373903005840 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 373903005841 binuclear metal center [ion binding]; other site 373903005842 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 373903005843 iron binding site [ion binding]; other site 373903005844 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 373903005845 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 373903005846 trimer interface [polypeptide binding]; other site 373903005847 active site 373903005848 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 373903005849 catalytic site [active] 373903005850 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 373903005851 Helix-turn-helix domains; Region: HTH; cl00088 373903005852 GAF domain; Region: GAF; cl15785 373903005853 Late competence development protein ComFB; Region: ComFB; pfam10719 373903005854 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 373903005855 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 373903005856 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 373903005857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 373903005858 active site 373903005859 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373903005860 dimer interface [polypeptide binding]; other site 373903005861 substrate binding site [chemical binding]; other site 373903005862 catalytic residue [active] 373903005863 biotin synthase; Provisional; Region: PRK07094 373903005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903005865 FeS/SAM binding site; other site 373903005866 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 373903005867 Predicted acetyltransferase [General function prediction only]; Region: COG3393 373903005868 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 373903005869 pyrophosphatase PpaX; Provisional; Region: PRK13288 373903005870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903005871 motif II; other site 373903005872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903005873 DNA binding site [nucleotide binding] 373903005874 domain linker motif; other site 373903005875 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 373903005876 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 373903005877 ligand binding site [chemical binding]; other site 373903005878 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 373903005879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 373903005880 classical (c) SDRs; Region: SDR_c; cd05233 373903005881 NAD(P) binding site [chemical binding]; other site 373903005882 active site 373903005883 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 373903005884 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 373903005885 trimer interface I [polypeptide binding]; other site 373903005886 putative substrate binding pocket [chemical binding]; other site 373903005887 trimer interface II [polypeptide binding]; other site 373903005888 putative hydrolase; Validated; Region: PRK09248 373903005889 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373903005890 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 373903005891 putative dimer interface [polypeptide binding]; other site 373903005892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903005893 H+ Antiporter protein; Region: 2A0121; TIGR00900 373903005894 putative substrate translocation pore; other site 373903005895 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 373903005896 active site 373903005897 catalytic residues [active] 373903005898 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 373903005899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 373903005900 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 373903005901 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 373903005902 Walker A/P-loop; other site 373903005903 ATP binding site [chemical binding]; other site 373903005904 Q-loop/lid; other site 373903005905 ABC transporter signature motif; other site 373903005906 Walker B; other site 373903005907 D-loop; other site 373903005908 H-loop/switch region; other site 373903005909 potential frameshift: common BLAST hit: gi|158320973|ref|YP_001513480.1| ABC transporter related 373903005910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903005911 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373903005912 Walker A/P-loop; other site 373903005913 ATP binding site [chemical binding]; other site 373903005914 Q-loop/lid; other site 373903005915 ABC transporter signature motif; other site 373903005916 Walker B; other site 373903005917 D-loop; other site 373903005918 H-loop/switch region; other site 373903005919 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 373903005920 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 373903005921 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 373903005922 G1 box; other site 373903005923 GTP/Mg2+ binding site [chemical binding]; other site 373903005924 Switch I region; other site 373903005925 G2 box; other site 373903005926 Switch II region; other site 373903005927 G3 box; other site 373903005928 G4 box; other site 373903005929 G5 box; other site 373903005930 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 373903005931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903005932 FeS/SAM binding site; other site 373903005933 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 373903005934 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 373903005935 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 373903005936 PhoU domain; Region: PhoU; pfam01895 373903005937 PhoU domain; Region: PhoU; pfam01895 373903005938 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373903005939 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 373903005940 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 373903005941 putative homodimer interface [polypeptide binding]; other site 373903005942 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 373903005943 ATP synthase subunit D; Region: ATP-synt_D; cl00613 373903005944 V-type ATP synthase subunit B; Provisional; Region: PRK04196 373903005945 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 373903005946 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 373903005947 Walker A motif homologous position; other site 373903005948 Walker B motif; other site 373903005949 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373903005950 V-type ATP synthase subunit A; Provisional; Region: PRK04192 373903005951 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 373903005952 Walker A motif/ATP binding site; other site 373903005953 Walker B motif; other site 373903005954 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373903005955 Plant ATP synthase F0; Region: YMF19; cl07975 373903005956 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 373903005957 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 373903005958 ATP synthase subunit C; Region: ATP-synt_C; cl00466 373903005959 V-type ATP synthase subunit I; Validated; Region: PRK05771 373903005960 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 373903005961 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 373903005962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 373903005963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903005964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903005965 dimer interface [polypeptide binding]; other site 373903005966 putative CheW interface [polypeptide binding]; other site 373903005967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373903005968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373903005969 TM-ABC transporter signature motif; other site 373903005970 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 373903005971 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 373903005972 Walker A/P-loop; other site 373903005973 ATP binding site [chemical binding]; other site 373903005974 Q-loop/lid; other site 373903005975 ABC transporter signature motif; other site 373903005976 Walker B; other site 373903005977 D-loop; other site 373903005978 H-loop/switch region; other site 373903005979 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 373903005980 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 373903005981 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 373903005982 putative ligand binding site [chemical binding]; other site 373903005983 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 373903005984 N- and C-terminal domain interface [polypeptide binding]; other site 373903005985 D-xylulose kinase; Region: XylB; TIGR01312 373903005986 active site 373903005987 catalytic site [active] 373903005988 metal binding site [ion binding]; metal-binding site 373903005989 xylulose binding site [chemical binding]; other site 373903005990 putative ATP binding site [chemical binding]; other site 373903005991 homodimer interface [polypeptide binding]; other site 373903005992 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 373903005993 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 373903005994 Helix-turn-helix domains; Region: HTH; cl00088 373903005995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373903005996 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903005997 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903005998 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 373903005999 carbohydrate binding site [chemical binding]; other site 373903006000 pullulanase, type I; Region: pulA_typeI; TIGR02104 373903006001 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 373903006002 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 373903006003 Ca binding site [ion binding]; other site 373903006004 active site 373903006005 catalytic site [active] 373903006006 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 373903006007 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 373903006008 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 373903006009 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 373903006010 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 373903006011 homodimer interface [polypeptide binding]; other site 373903006012 substrate-cofactor binding pocket; other site 373903006013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903006014 catalytic residue [active] 373903006015 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 373903006016 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 373903006017 FAD binding site [chemical binding]; other site 373903006018 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 373903006019 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 373903006020 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 373903006021 substrate binding pocket [chemical binding]; other site 373903006022 dimer interface [polypeptide binding]; other site 373903006023 inhibitor binding site; inhibition site 373903006024 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 373903006025 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 373903006026 B12 binding site [chemical binding]; other site 373903006027 cobalt ligand [ion binding]; other site 373903006028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373903006029 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 373903006030 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 373903006031 Surface antigen; Region: Bac_surface_Ag; cl03097 373903006032 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 373903006033 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903006034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373903006035 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 373903006036 Walker A/P-loop; other site 373903006037 ATP binding site [chemical binding]; other site 373903006038 Q-loop/lid; other site 373903006039 ABC transporter signature motif; other site 373903006040 Walker B; other site 373903006041 D-loop; other site 373903006042 H-loop/switch region; other site 373903006043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903006044 TPR motif; other site 373903006045 binding surface 373903006046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373903006047 Histidine kinase; Region: HisKA_3; pfam07730 373903006048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903006049 ATP binding site [chemical binding]; other site 373903006050 Mg2+ binding site [ion binding]; other site 373903006051 G-X-G motif; other site 373903006052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373903006053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903006054 active site 373903006055 phosphorylation site [posttranslational modification] 373903006056 intermolecular recognition site; other site 373903006057 dimerization interface [polypeptide binding]; other site 373903006058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373903006059 DNA binding residues [nucleotide binding] 373903006060 dimerization interface [polypeptide binding]; other site 373903006061 ABC-2 type transporter; Region: ABC2_membrane; cl11417 373903006062 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 373903006063 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 373903006064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006065 Walker A/P-loop; other site 373903006066 ATP binding site [chemical binding]; other site 373903006067 Q-loop/lid; other site 373903006068 ABC transporter signature motif; other site 373903006069 Walker B; other site 373903006070 D-loop; other site 373903006071 H-loop/switch region; other site 373903006072 Cache domain; Region: Cache_1; pfam02743 373903006073 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 373903006074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006075 dimerization interface [polypeptide binding]; other site 373903006076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903006077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006078 dimer interface [polypeptide binding]; other site 373903006079 putative CheW interface [polypeptide binding]; other site 373903006080 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 373903006081 Putative carbohydrate binding domain; Region: CBM_X; cl05621 373903006082 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 373903006083 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 373903006084 Putative carbohydrate binding domain; Region: CBM_X; cl05621 373903006085 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 373903006086 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 373903006087 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 373903006088 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 373903006089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903006090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006092 dimer interface [polypeptide binding]; other site 373903006093 conserved gate region; other site 373903006094 putative PBP binding loops; other site 373903006095 ABC-ATPase subunit interface; other site 373903006096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006097 dimer interface [polypeptide binding]; other site 373903006098 conserved gate region; other site 373903006099 ABC-ATPase subunit interface; other site 373903006100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903006101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903006102 DNA binding site [nucleotide binding] 373903006103 domain linker motif; other site 373903006104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903006105 ligand binding site [chemical binding]; other site 373903006106 dimerization interface [polypeptide binding]; other site 373903006107 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 373903006108 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 373903006109 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 373903006110 Fibronectin type III-like domain; Region: Fn3-like; cl15273 373903006111 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 373903006112 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006113 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006114 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006115 Leucine rich repeat; Region: LRR_8; pfam13855 373903006116 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 373903006117 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006118 Leucine-rich repeats; other site 373903006119 Substrate binding site [chemical binding]; other site 373903006120 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006121 Leucine rich repeat; Region: LRR_8; pfam13855 373903006122 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006123 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006124 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373903006125 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 373903006126 Cache domain; Region: Cache_1; pfam02743 373903006127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006128 dimerization interface [polypeptide binding]; other site 373903006129 Histidine kinase; Region: His_kinase; pfam06580 373903006130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903006131 ATP binding site [chemical binding]; other site 373903006132 Mg2+ binding site [ion binding]; other site 373903006133 G-X-G motif; other site 373903006134 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 373903006135 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 373903006136 ligand binding site [chemical binding]; other site 373903006137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903006138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006139 dimer interface [polypeptide binding]; other site 373903006140 conserved gate region; other site 373903006141 putative PBP binding loops; other site 373903006142 ABC-ATPase subunit interface; other site 373903006143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006144 dimer interface [polypeptide binding]; other site 373903006145 conserved gate region; other site 373903006146 putative PBP binding loops; other site 373903006147 ABC-ATPase subunit interface; other site 373903006148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006149 dimerization interface [polypeptide binding]; other site 373903006150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006151 dimer interface [polypeptide binding]; other site 373903006152 putative CheW interface [polypeptide binding]; other site 373903006153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903006154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006155 Response regulator receiver domain; Region: Response_reg; pfam00072 373903006156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903006157 active site 373903006158 phosphorylation site [posttranslational modification] 373903006159 intermolecular recognition site; other site 373903006160 dimerization interface [polypeptide binding]; other site 373903006161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373903006162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903006163 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 373903006164 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 373903006165 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 373903006166 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 373903006167 tetramer interface [polypeptide binding]; other site 373903006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903006169 catalytic residue [active] 373903006170 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373903006171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006172 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903006173 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 373903006174 putative substrate binding site [chemical binding]; other site 373903006175 putative ATP binding site [chemical binding]; other site 373903006176 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 373903006177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006178 Walker A/P-loop; other site 373903006179 ATP binding site [chemical binding]; other site 373903006180 Q-loop/lid; other site 373903006181 ABC transporter signature motif; other site 373903006182 Walker B; other site 373903006183 D-loop; other site 373903006184 H-loop/switch region; other site 373903006185 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 373903006186 TM-ABC transporter signature motif; other site 373903006187 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 373903006188 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 373903006189 zinc binding site [ion binding]; other site 373903006190 putative ligand binding site [chemical binding]; other site 373903006191 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 373903006192 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373903006193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373903006194 catalytic residue [active] 373903006195 DsrE/DsrF-like family; Region: DrsE; cl00672 373903006196 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 373903006197 Flagellin N-methylase; Region: FliB; cl00497 373903006198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903006199 Helix-turn-helix domains; Region: HTH; cl00088 373903006200 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373903006201 Predicted permeases [General function prediction only]; Region: COG0701 373903006202 Predicted permease; Region: DUF318; pfam03773 373903006203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903006204 dimerization interface [polypeptide binding]; other site 373903006205 putative DNA binding site [nucleotide binding]; other site 373903006206 putative Zn2+ binding site [ion binding]; other site 373903006207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903006208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373903006209 putative substrate translocation pore; other site 373903006210 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 373903006211 4Fe-4S binding domain; Region: Fer4; cl02805 373903006212 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373903006213 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373903006214 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373903006215 dimerization domain swap beta strand [polypeptide binding]; other site 373903006216 regulatory protein interface [polypeptide binding]; other site 373903006217 active site 373903006218 regulatory phosphorylation site [posttranslational modification]; other site 373903006219 Predicted transcriptional regulator [Transcription]; Region: COG2378 373903006220 Helix-turn-helix domains; Region: HTH; cl00088 373903006221 Helix-turn-helix domains; Region: HTH; cl00088 373903006222 PRD domain; Region: PRD; cl15445 373903006223 PRD domain; Region: PRD; cl15445 373903006224 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 373903006225 P-loop; other site 373903006226 active site 373903006227 phosphorylation site [posttranslational modification] 373903006228 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373903006229 active site 373903006230 phosphorylation site [posttranslational modification] 373903006231 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 373903006232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373903006233 non-specific DNA binding site [nucleotide binding]; other site 373903006234 salt bridge; other site 373903006235 sequence-specific DNA binding site [nucleotide binding]; other site 373903006236 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373903006237 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373903006238 HsdM N-terminal domain; Region: HsdM_N; pfam12161 373903006239 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 373903006240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006241 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 373903006242 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 373903006243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903006244 ATP binding site [chemical binding]; other site 373903006245 putative Mg++ binding site [ion binding]; other site 373903006246 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 373903006247 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 373903006248 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 373903006249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903006250 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 373903006251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903006252 active site 373903006253 phosphorylation site [posttranslational modification] 373903006254 intermolecular recognition site; other site 373903006255 dimerization interface [polypeptide binding]; other site 373903006256 CheB methylesterase; Region: CheB_methylest; pfam01339 373903006257 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 373903006258 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373903006259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006260 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 373903006261 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 373903006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006263 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 373903006264 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 373903006265 active site 373903006266 HIGH motif; other site 373903006267 KMSKS motif; other site 373903006268 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 373903006269 tRNA binding surface [nucleotide binding]; other site 373903006270 anticodon binding site; other site 373903006271 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 373903006272 dimer interface [polypeptide binding]; other site 373903006273 putative tRNA-binding site [nucleotide binding]; other site 373903006274 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 373903006275 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 373903006276 dimer interface [polypeptide binding]; other site 373903006277 active site 373903006278 metal binding site [ion binding]; metal-binding site 373903006279 Predicted methyltransferases [General function prediction only]; Region: COG0313 373903006280 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 373903006281 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 373903006282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903006283 S-adenosylmethionine binding site [chemical binding]; other site 373903006284 Protein of unknown function (DUF972); Region: DUF972; pfam06156 373903006285 PSP1 C-terminal conserved region; Region: PSP1; cl00770 373903006286 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 373903006287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006288 Nitrogen regulatory protein P-II; Region: P-II; cl00412 373903006289 thymidylate kinase; Validated; Region: tmk; PRK00698 373903006290 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 373903006291 TMP-binding site; other site 373903006292 ATP-binding site [chemical binding]; other site 373903006293 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903006294 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 373903006295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373903006297 FlgD Ig-like domain; Region: FlgD_ig; cl15790 373903006298 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 373903006299 Fibronectin type III-like domain; Region: Fn3-like; cl15273 373903006300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903006301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006302 dimer interface [polypeptide binding]; other site 373903006303 conserved gate region; other site 373903006304 putative PBP binding loops; other site 373903006305 ABC-ATPase subunit interface; other site 373903006306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006307 dimer interface [polypeptide binding]; other site 373903006308 conserved gate region; other site 373903006309 putative PBP binding loops; other site 373903006310 ABC-ATPase subunit interface; other site 373903006311 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 373903006312 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006313 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 373903006314 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 373903006315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 373903006316 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 373903006317 active site 373903006318 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 373903006319 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373903006320 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 373903006321 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903006322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006323 dimer interface [polypeptide binding]; other site 373903006324 conserved gate region; other site 373903006325 putative PBP binding loops; other site 373903006326 ABC-ATPase subunit interface; other site 373903006327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006328 dimer interface [polypeptide binding]; other site 373903006329 conserved gate region; other site 373903006330 putative PBP binding loops; other site 373903006331 ABC-ATPase subunit interface; other site 373903006332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903006333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903006336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903006337 DNA binding site [nucleotide binding] 373903006338 domain linker motif; other site 373903006339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903006340 ligand binding site [chemical binding]; other site 373903006341 dimerization interface [polypeptide binding]; other site 373903006342 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 373903006343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903006345 binding surface 373903006346 TPR motif; other site 373903006347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373903006348 DNA binding residues [nucleotide binding] 373903006349 dimerization interface [polypeptide binding]; other site 373903006350 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 373903006351 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 373903006352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373903006353 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 373903006354 active site 373903006355 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 373903006356 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373903006357 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 373903006358 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 373903006359 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903006360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006361 dimer interface [polypeptide binding]; other site 373903006362 conserved gate region; other site 373903006363 putative PBP binding loops; other site 373903006364 ABC-ATPase subunit interface; other site 373903006365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006366 dimer interface [polypeptide binding]; other site 373903006367 conserved gate region; other site 373903006368 putative PBP binding loops; other site 373903006369 ABC-ATPase subunit interface; other site 373903006370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903006372 Predicted transcriptional regulator [Transcription]; Region: COG4189 373903006373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903006374 putative DNA binding site [nucleotide binding]; other site 373903006375 dimerization interface [polypeptide binding]; other site 373903006376 putative Zn2+ binding site [ion binding]; other site 373903006377 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 373903006378 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 373903006379 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 373903006380 active site 373903006381 galactokinase; Provisional; Region: PRK05322 373903006382 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 373903006383 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373903006384 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 373903006385 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 373903006386 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 373903006387 dimer interface [polypeptide binding]; other site 373903006388 active site 373903006389 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 373903006390 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 373903006391 NAD binding site [chemical binding]; other site 373903006392 homodimer interface [polypeptide binding]; other site 373903006393 active site 373903006394 substrate binding site [chemical binding]; other site 373903006395 Helix-turn-helix domains; Region: HTH; cl00088 373903006396 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373903006397 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903006398 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 373903006399 4Fe-4S binding domain; Region: Fer4; cl02805 373903006400 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 373903006401 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 373903006402 TPP-binding site [chemical binding]; other site 373903006403 putative dimer interface [polypeptide binding]; other site 373903006404 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 373903006405 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373903006406 dimer interface [polypeptide binding]; other site 373903006407 PYR/PP interface [polypeptide binding]; other site 373903006408 TPP binding site [chemical binding]; other site 373903006409 substrate binding site [chemical binding]; other site 373903006410 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 373903006411 4Fe-4S binding domain; Region: Fer4; cl02805 373903006412 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 373903006413 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 373903006414 Protein of unknown function, DUF606; Region: DUF606; cl01273 373903006415 recombination protein RecR; Reviewed; Region: recR; PRK00076 373903006416 RecR protein; Region: RecR; pfam02132 373903006417 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 373903006418 putative active site [active] 373903006419 putative metal-binding site [ion binding]; other site 373903006420 tetramer interface [polypeptide binding]; other site 373903006421 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 373903006422 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 373903006423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903006424 Walker A motif; other site 373903006425 ATP binding site [chemical binding]; other site 373903006426 Walker B motif; other site 373903006427 arginine finger; other site 373903006428 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 373903006429 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 373903006430 nucleoside/Zn binding site; other site 373903006431 dimer interface [polypeptide binding]; other site 373903006432 catalytic motif [active] 373903006433 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 373903006434 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373903006435 dimer interface [polypeptide binding]; other site 373903006436 PYR/PP interface [polypeptide binding]; other site 373903006437 TPP binding site [chemical binding]; other site 373903006438 substrate binding site [chemical binding]; other site 373903006439 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 373903006440 Domain of unknown function; Region: EKR; cl11037 373903006441 4Fe-4S binding domain; Region: Fer4; cl02805 373903006442 4Fe-4S binding domain; Region: Fer4; cl02805 373903006443 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 373903006444 TPP-binding site [chemical binding]; other site 373903006445 dimer interface [polypeptide binding]; other site 373903006446 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373903006447 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373903006448 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373903006449 Cache domain; Region: Cache_1; pfam02743 373903006450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 373903006451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903006452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006453 dimer interface [polypeptide binding]; other site 373903006454 putative CheW interface [polypeptide binding]; other site 373903006455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373903006456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006457 dimer interface [polypeptide binding]; other site 373903006458 conserved gate region; other site 373903006459 putative PBP binding loops; other site 373903006460 ABC-ATPase subunit interface; other site 373903006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006462 dimer interface [polypeptide binding]; other site 373903006463 conserved gate region; other site 373903006464 putative PBP binding loops; other site 373903006465 ABC-ATPase subunit interface; other site 373903006466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903006467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006468 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903006469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903006470 DNA binding site [nucleotide binding] 373903006471 domain linker motif; other site 373903006472 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903006473 dimerization interface [polypeptide binding]; other site 373903006474 ligand binding site [chemical binding]; other site 373903006475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 373903006476 YheO-like PAS domain; Region: PAS_6; pfam08348 373903006477 Helix-turn-helix domains; Region: HTH; cl00088 373903006478 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 373903006479 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 373903006480 substrate binding site [chemical binding]; other site 373903006481 tetramer interface [polypeptide binding]; other site 373903006482 catalytic residue [active] 373903006483 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 373903006484 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373903006485 homotrimer interaction site [polypeptide binding]; other site 373903006486 putative active site [active] 373903006487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 373903006488 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 373903006489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373903006490 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 373903006491 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 373903006492 Ligand Binding Site [chemical binding]; other site 373903006493 Predicted transcriptional regulator [Transcription]; Region: COG2932 373903006494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373903006495 non-specific DNA binding site [nucleotide binding]; other site 373903006496 salt bridge; other site 373903006497 sequence-specific DNA binding site [nucleotide binding]; other site 373903006498 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373903006499 Catalytic site [active] 373903006500 CrcB-like protein; Region: CRCB; cl09114 373903006501 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 373903006502 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 373903006503 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 373903006504 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 373903006505 Cache domain; Region: Cache_1; pfam02743 373903006506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 373903006507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903006508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006509 dimer interface [polypeptide binding]; other site 373903006510 putative CheW interface [polypeptide binding]; other site 373903006511 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 373903006512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373903006513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373903006514 Protein of unknown function DUF89; Region: DUF89; cl15397 373903006515 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 373903006516 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373903006517 E3 interaction surface; other site 373903006518 lipoyl attachment site [posttranslational modification]; other site 373903006519 HlyD family secretion protein; Region: HlyD; pfam00529 373903006520 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 373903006521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373903006523 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373903006524 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 373903006525 putative hydratase; Provisional; Region: PRK11413 373903006526 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 373903006527 substrate binding site [chemical binding]; other site 373903006528 ligand binding site [chemical binding]; other site 373903006529 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 373903006530 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 373903006531 substrate binding site [chemical binding]; other site 373903006532 seryl-tRNA synthetase; Provisional; Region: PRK05431 373903006533 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 373903006534 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 373903006535 dimer interface [polypeptide binding]; other site 373903006536 active site 373903006537 motif 1; other site 373903006538 motif 2; other site 373903006539 motif 3; other site 373903006540 T-box leader 373903006541 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 373903006542 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 373903006543 B12 binding site [chemical binding]; other site 373903006544 cobalt ligand [ion binding]; other site 373903006545 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 373903006546 MutL protein; Region: MutL; pfam13941 373903006547 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 373903006548 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 373903006549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373903006550 catalytic residue [active] 373903006551 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 373903006552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006553 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 373903006554 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 373903006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006556 SurA N-terminal domain; Region: SurA_N_3; cl07813 373903006557 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 373903006558 PPIC-type PPIASE domain; Region: Rotamase; cl08278 373903006559 Stage II sporulation protein; Region: SpoIID; pfam08486 373903006560 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 373903006561 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 373903006562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 373903006563 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 373903006564 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 373903006565 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 373903006566 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 373903006567 stage V sporulation protein B; Region: spore_V_B; TIGR02900 373903006568 MatE; Region: MatE; cl10513 373903006569 MatE; Region: MatE; cl10513 373903006570 stage V sporulation protein T; Region: spore_V_T; TIGR02851 373903006571 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 373903006572 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 373903006573 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 373903006574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373903006575 ATP binding site [chemical binding]; other site 373903006576 putative Mg++ binding site [ion binding]; other site 373903006577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373903006578 nucleotide binding region [chemical binding]; other site 373903006579 ATP-binding site [chemical binding]; other site 373903006580 TRCF domain; Region: TRCF; cl04088 373903006581 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 373903006582 putative active site [active] 373903006583 catalytic residue [active] 373903006584 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 373903006585 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 373903006586 5S rRNA interface [nucleotide binding]; other site 373903006587 CTC domain interface [polypeptide binding]; other site 373903006588 L16 interface [polypeptide binding]; other site 373903006589 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 373903006590 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 373903006591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903006592 active site 373903006593 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 373903006594 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 373903006595 Substrate binding site; other site 373903006596 Mg++ binding site; other site 373903006597 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 373903006598 active site 373903006599 substrate binding site [chemical binding]; other site 373903006600 CoA binding site [chemical binding]; other site 373903006601 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 373903006602 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 373903006603 SpoVG; Region: SpoVG; cl00915 373903006604 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 373903006605 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 373903006606 dimerization interface [polypeptide binding]; other site 373903006607 putative ATP binding site [chemical binding]; other site 373903006608 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 373903006609 glutamine synthetase, type I; Region: GlnA; TIGR00653 373903006610 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 373903006611 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 373903006612 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 373903006613 DNA binding residues [nucleotide binding] 373903006614 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 373903006615 putative dimer interface [polypeptide binding]; other site 373903006616 hypothetical protein; Provisional; Region: PRK06851 373903006617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006618 Walker A motif; other site 373903006619 ATP binding site [chemical binding]; other site 373903006620 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 373903006621 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 373903006622 GAF domain; Region: GAF; cl15785 373903006623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373903006624 metal binding site [ion binding]; metal-binding site 373903006625 active site 373903006626 I-site; other site 373903006627 pur operon repressor; Provisional; Region: PRK09213 373903006628 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 373903006629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903006630 active site 373903006631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373903006632 active site 373903006633 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 373903006634 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373903006635 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 373903006636 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 373903006637 putative catalytic site [active] 373903006638 putative metal binding site [ion binding]; other site 373903006639 putative phosphate binding site [ion binding]; other site 373903006640 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 373903006641 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006642 putative peptidoglycan binding site; other site 373903006643 calcium/proton exchanger (cax); Region: cax; TIGR00378 373903006644 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373903006645 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373903006646 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006647 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006648 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006649 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006650 putative peptidoglycan binding site; other site 373903006651 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006652 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006653 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006654 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006655 putative peptidoglycan binding site; other site 373903006656 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006657 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006658 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 373903006659 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 373903006660 PspC domain; Region: PspC; cl00864 373903006661 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373903006662 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 373903006663 NMT1-like family; Region: NMT1_2; cl15260 373903006664 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 373903006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006666 dimer interface [polypeptide binding]; other site 373903006667 conserved gate region; other site 373903006668 putative PBP binding loops; other site 373903006669 ABC-ATPase subunit interface; other site 373903006670 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 373903006671 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 373903006672 Walker A/P-loop; other site 373903006673 ATP binding site [chemical binding]; other site 373903006674 Q-loop/lid; other site 373903006675 ABC transporter signature motif; other site 373903006676 Walker B; other site 373903006677 D-loop; other site 373903006678 H-loop/switch region; other site 373903006679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 373903006680 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 373903006681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373903006682 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 373903006683 Walker A/P-loop; other site 373903006684 ATP binding site [chemical binding]; other site 373903006685 Q-loop/lid; other site 373903006686 ABC transporter signature motif; other site 373903006687 Walker B; other site 373903006688 D-loop; other site 373903006689 H-loop/switch region; other site 373903006690 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 373903006691 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 373903006692 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 373903006693 PhoU domain; Region: PhoU; pfam01895 373903006694 PhoU domain; Region: PhoU; pfam01895 373903006695 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 373903006696 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 373903006697 Walker A/P-loop; other site 373903006698 ATP binding site [chemical binding]; other site 373903006699 Q-loop/lid; other site 373903006700 ABC transporter signature motif; other site 373903006701 Walker B; other site 373903006702 D-loop; other site 373903006703 H-loop/switch region; other site 373903006704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006705 dimer interface [polypeptide binding]; other site 373903006706 conserved gate region; other site 373903006707 putative PBP binding loops; other site 373903006708 ABC-ATPase subunit interface; other site 373903006709 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 373903006710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006711 dimer interface [polypeptide binding]; other site 373903006712 conserved gate region; other site 373903006713 putative PBP binding loops; other site 373903006714 ABC-ATPase subunit interface; other site 373903006715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006716 Cache domain; Region: Cache_1; pfam02743 373903006717 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 373903006718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006719 dimerization interface [polypeptide binding]; other site 373903006720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006721 dimer interface [polypeptide binding]; other site 373903006722 putative CheW interface [polypeptide binding]; other site 373903006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006724 dimer interface [polypeptide binding]; other site 373903006725 conserved gate region; other site 373903006726 putative PBP binding loops; other site 373903006727 ABC-ATPase subunit interface; other site 373903006728 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 373903006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006730 dimer interface [polypeptide binding]; other site 373903006731 conserved gate region; other site 373903006732 putative PBP binding loops; other site 373903006733 ABC-ATPase subunit interface; other site 373903006734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903006735 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373903006736 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 373903006737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006738 dimerization interface [polypeptide binding]; other site 373903006739 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 373903006740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 373903006741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373903006742 dimer interface [polypeptide binding]; other site 373903006743 phosphorylation site [posttranslational modification] 373903006744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903006745 ATP binding site [chemical binding]; other site 373903006746 Mg2+ binding site [ion binding]; other site 373903006747 G-X-G motif; other site 373903006748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 373903006749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903006750 active site 373903006751 phosphorylation site [posttranslational modification] 373903006752 intermolecular recognition site; other site 373903006753 dimerization interface [polypeptide binding]; other site 373903006754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373903006755 DNA binding site [nucleotide binding] 373903006756 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 373903006757 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373903006758 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373903006759 PhoU domain; Region: PhoU; pfam01895 373903006760 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373903006761 Glyco_18 domain; Region: Glyco_18; smart00636 373903006762 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 373903006763 active site 373903006764 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 373903006765 YabG peptidase U57; Region: Peptidase_U57; cl05250 373903006766 Protein of unknown function (DUF458); Region: DUF458; cl00861 373903006767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903006769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373903006770 putative substrate translocation pore; other site 373903006771 Protein of unknown function (DUF441); Region: DUF441; cl01041 373903006772 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 373903006773 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 373903006774 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 373903006775 active site 373903006776 intersubunit interactions; other site 373903006777 catalytic residue [active] 373903006778 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 373903006779 Glyco_18 domain; Region: Glyco_18; smart00636 373903006780 active site 373903006781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373903006782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903006783 active site 373903006784 phosphorylation site [posttranslational modification] 373903006785 intermolecular recognition site; other site 373903006786 dimerization interface [polypeptide binding]; other site 373903006787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373903006788 DNA binding residues [nucleotide binding] 373903006789 dimerization interface [polypeptide binding]; other site 373903006790 Sensor protein DegS; Region: DegS; pfam05384 373903006791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 373903006792 Histidine kinase; Region: HisKA_3; pfam07730 373903006793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903006794 ATP binding site [chemical binding]; other site 373903006795 Mg2+ binding site [ion binding]; other site 373903006796 G-X-G motif; other site 373903006797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903006798 stage V sporulation protein B; Region: spore_V_B; TIGR02900 373903006799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006800 dimer interface [polypeptide binding]; other site 373903006801 putative CheW interface [polypeptide binding]; other site 373903006802 4Fe-4S binding domain; Region: Fer4; cl02805 373903006803 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 373903006804 Acetokinase family; Region: Acetate_kinase; cl01029 373903006805 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 373903006806 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 373903006807 catalytic triad [active] 373903006808 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 373903006809 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 373903006810 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 373903006811 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373903006812 active site 373903006813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373903006814 H+ Antiporter protein; Region: 2A0121; TIGR00900 373903006815 putative substrate translocation pore; other site 373903006816 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 373903006817 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 373903006818 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 373903006819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373903006820 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 373903006821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373903006822 motif II; other site 373903006823 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 373903006824 CAAX protease self-immunity; Region: Abi; cl00558 373903006825 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 373903006826 Heme NO binding; Region: HNOB; cl15268 373903006827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006828 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903006829 dimer interface [polypeptide binding]; other site 373903006830 putative CheW interface [polypeptide binding]; other site 373903006831 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 373903006832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903006833 Zn2+ binding site [ion binding]; other site 373903006834 Mg2+ binding site [ion binding]; other site 373903006835 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006836 putative peptidoglycan binding site; other site 373903006837 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903006838 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006839 putative peptidoglycan binding site; other site 373903006840 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903006841 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006842 putative peptidoglycan binding site; other site 373903006843 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 373903006844 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006845 putative peptidoglycan binding site; other site 373903006846 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 373903006847 stage V sporulation protein B; Region: spore_V_B; TIGR02900 373903006848 MatE; Region: MatE; cl10513 373903006849 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373903006850 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 373903006851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373903006852 catalytic residue [active] 373903006853 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 373903006854 THUMP domain; Region: THUMP; cl12076 373903006855 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 373903006856 Protein of unknown function (DUF421); Region: DUF421; cl00990 373903006857 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 373903006858 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 373903006859 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 373903006860 purine monophosphate binding site [chemical binding]; other site 373903006861 dimer interface [polypeptide binding]; other site 373903006862 putative catalytic residues [active] 373903006863 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 373903006864 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 373903006865 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 373903006866 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 373903006867 active site 373903006868 substrate binding site [chemical binding]; other site 373903006869 cosubstrate binding site; other site 373903006870 catalytic site [active] 373903006871 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 373903006872 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 373903006873 dimerization interface [polypeptide binding]; other site 373903006874 putative ATP binding site [chemical binding]; other site 373903006875 amidophosphoribosyltransferase; Provisional; Region: PRK09123 373903006876 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 373903006877 active site 373903006878 tetramer interface [polypeptide binding]; other site 373903006879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373903006880 active site 373903006881 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 373903006882 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 373903006883 dimerization interface [polypeptide binding]; other site 373903006884 ATP binding site [chemical binding]; other site 373903006885 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 373903006886 dimerization interface [polypeptide binding]; other site 373903006887 ATP binding site [chemical binding]; other site 373903006888 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 373903006889 putative active site [active] 373903006890 catalytic triad [active] 373903006891 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 373903006892 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 373903006893 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 373903006894 ATP binding site [chemical binding]; other site 373903006895 active site 373903006896 substrate binding site [chemical binding]; other site 373903006897 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 373903006898 Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595 373903006899 tetramer interface [polypeptide binding]; other site 373903006900 active site 373903006901 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 373903006902 ParB-like partition proteins; Region: parB_part; TIGR00180 373903006903 ParB-like nuclease domain; Region: ParBc; cl02129 373903006904 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 373903006905 FAD binding domain; Region: FAD_binding_4; pfam01565 373903006906 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 373903006907 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 373903006908 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 373903006909 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 373903006910 active site 373903006911 dimer interface [polypeptide binding]; other site 373903006912 effector binding site; other site 373903006913 TSCPD domain; Region: TSCPD; cl14834 373903006914 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373903006915 polysaccharide export protein Wza; Provisional; Region: PRK15078 373903006916 SLBB domain; Region: SLBB; pfam10531 373903006917 Chain length determinant protein; Region: Wzz; cl15801 373903006918 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 373903006919 Chain length determinant protein; Region: Wzz; cl15801 373903006920 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 373903006921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 373903006922 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006923 putative peptidoglycan binding site; other site 373903006924 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 373903006925 putative peptidoglycan binding site; other site 373903006926 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 373903006927 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 373903006928 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 373903006929 NMT1-like family; Region: NMT1_2; cl15260 373903006930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903006931 dimer interface [polypeptide binding]; other site 373903006932 conserved gate region; other site 373903006933 ABC-ATPase subunit interface; other site 373903006934 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 373903006935 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 373903006936 Walker A/P-loop; other site 373903006937 ATP binding site [chemical binding]; other site 373903006938 Q-loop/lid; other site 373903006939 ABC transporter signature motif; other site 373903006940 Walker B; other site 373903006941 D-loop; other site 373903006942 H-loop/switch region; other site 373903006943 NIL domain; Region: NIL; cl09633 373903006944 Membrane transport protein; Region: Mem_trans; cl09117 373903006945 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373903006946 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373903006947 transmembrane helices; other site 373903006948 Domain of unknown function (DUF3480); Region: DUF3480; pfam11979 373903006949 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 373903006950 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373903006951 putative active site [active] 373903006952 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 373903006953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373903006954 dimerization interface [polypeptide binding]; other site 373903006955 putative DNA binding site [nucleotide binding]; other site 373903006956 putative Zn2+ binding site [ion binding]; other site 373903006957 Cache domain; Region: Cache_1; pfam02743 373903006958 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 373903006959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903006960 dimerization interface [polypeptide binding]; other site 373903006961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903006962 dimer interface [polypeptide binding]; other site 373903006963 putative CheW interface [polypeptide binding]; other site 373903006964 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 373903006965 active site 373903006966 nucleophile elbow; other site 373903006967 asparagine synthetase B; Provisional; Region: asnB; PRK09431 373903006968 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 373903006969 active site 373903006970 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373903006971 Ligand Binding Site [chemical binding]; other site 373903006972 Molecular Tunnel; other site 373903006973 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 373903006974 hypothetical protein; Reviewed; Region: PRK09588 373903006975 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 373903006976 active site 373903006977 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 373903006978 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 373903006979 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 373903006980 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 373903006981 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 373903006982 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 373903006983 Rubredoxin; Region: Rubredoxin; pfam00301 373903006984 iron binding site [ion binding]; other site 373903006985 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 373903006986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 373903006987 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 373903006988 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 373903006989 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 373903006990 Ca binding site [ion binding]; other site 373903006991 active site 373903006992 catalytic site [active] 373903006993 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 373903006994 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903006995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903006996 DNA binding site [nucleotide binding] 373903006997 domain linker motif; other site 373903006998 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903006999 dimerization interface [polypeptide binding]; other site 373903007000 ligand binding site [chemical binding]; other site 373903007001 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373903007002 Cache domain; Region: Cache_1; pfam02743 373903007003 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 373903007004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373903007005 dimerization interface [polypeptide binding]; other site 373903007006 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903007007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903007008 dimer interface [polypeptide binding]; other site 373903007009 putative CheW interface [polypeptide binding]; other site 373903007010 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 373903007011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903007012 active site 373903007013 phosphorylation site [posttranslational modification] 373903007014 intermolecular recognition site; other site 373903007015 dimerization interface [polypeptide binding]; other site 373903007016 CheB methylesterase; Region: CheB_methylest; pfam01339 373903007017 CheD chemotactic sensory transduction; Region: CheD; cl00810 373903007018 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373903007019 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 373903007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373903007021 S-adenosylmethionine binding site [chemical binding]; other site 373903007022 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 373903007023 putative CheA interaction surface; other site 373903007024 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 373903007025 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373903007026 putative binding surface; other site 373903007027 active site 373903007028 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373903007029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373903007030 ATP binding site [chemical binding]; other site 373903007031 Mg2+ binding site [ion binding]; other site 373903007032 G-X-G motif; other site 373903007033 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 373903007034 Response regulator receiver domain; Region: Response_reg; pfam00072 373903007035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373903007036 active site 373903007037 phosphorylation site [posttranslational modification] 373903007038 intermolecular recognition site; other site 373903007039 dimerization interface [polypeptide binding]; other site 373903007040 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373903007041 anti sigma factor interaction site; other site 373903007042 regulatory phosphorylation site [posttranslational modification]; other site 373903007043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903007044 dimer interface [polypeptide binding]; other site 373903007045 putative CheW interface [polypeptide binding]; other site 373903007046 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 373903007047 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 373903007048 ligand-binding site [chemical binding]; other site 373903007049 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 373903007050 ATP-sulfurylase; Region: ATPS; cd00517 373903007051 active site 373903007052 HXXH motif; other site 373903007053 flexible loop; other site 373903007054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 373903007055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373903007056 dimer interface [polypeptide binding]; other site 373903007057 putative CheW interface [polypeptide binding]; other site 373903007058 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 373903007059 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373903007060 substrate binding site [chemical binding]; other site 373903007061 ATP binding site [chemical binding]; other site 373903007062 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373903007063 TM-ABC transporter signature motif; other site 373903007064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 373903007065 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 373903007066 Walker A/P-loop; other site 373903007067 ATP binding site [chemical binding]; other site 373903007068 Q-loop/lid; other site 373903007069 ABC transporter signature motif; other site 373903007070 Walker B; other site 373903007071 D-loop; other site 373903007072 H-loop/switch region; other site 373903007073 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 373903007074 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 373903007075 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 373903007076 putative ligand binding site [chemical binding]; other site 373903007077 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 373903007078 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 373903007079 putative substrate binding site [chemical binding]; other site 373903007080 putative ATP binding site [chemical binding]; other site 373903007081 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 373903007082 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 373903007083 dimer interface [polypeptide binding]; other site 373903007084 active site 373903007085 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 373903007086 dimer interface [polypeptide binding]; other site 373903007087 active site 373903007088 hypothetical protein; Provisional; Region: PRK08185 373903007089 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 373903007090 intersubunit interface [polypeptide binding]; other site 373903007091 active site 373903007092 zinc binding site [ion binding]; other site 373903007093 Na+ binding site [ion binding]; other site 373903007094 Helix-turn-helix domains; Region: HTH; cl00088 373903007095 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373903007096 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 373903007097 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 373903007098 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 373903007099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903007100 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 373903007101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903007102 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 373903007103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903007104 NAD(P) binding site [chemical binding]; other site 373903007105 active site 373903007106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373903007107 active site 373903007108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903007109 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 373903007110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903007111 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373903007112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373903007113 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373903007114 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 373903007115 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373903007116 MatE; Region: MatE; cl10513 373903007117 MatE; Region: MatE; cl10513 373903007118 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 373903007119 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 373903007120 Substrate binding site; other site 373903007121 Cupin domain; Region: Cupin_2; cl09118 373903007122 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 373903007123 Chain length determinant protein; Region: Wzz; cl15801 373903007124 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 373903007125 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373903007126 Chain length determinant protein; Region: Wzz; cl15801 373903007127 Chain length determinant protein; Region: Wzz; cl15801 373903007128 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 373903007129 Chain length determinant protein; Region: Wzz; cl15801 373903007130 Bacterial sugar transferase; Region: Bac_transf; cl00939 373903007131 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 373903007132 active site 373903007133 trimer interface [polypeptide binding]; other site 373903007134 allosteric site; other site 373903007135 active site lid [active] 373903007136 hexamer (dimer of trimers) interface [polypeptide binding]; other site 373903007137 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 373903007138 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 373903007139 active site 373903007140 dimer interface [polypeptide binding]; other site 373903007141 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 373903007142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373903007143 DNA-binding site [nucleotide binding]; DNA binding site 373903007144 UTRA domain; Region: UTRA; cl01230 373903007145 Glycerate kinase family; Region: Gly_kinase; cl00841 373903007146 Predicted amidohydrolase [General function prediction only]; Region: COG0388 373903007147 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 373903007148 active site 373903007149 catalytic triad [active] 373903007150 dimer interface [polypeptide binding]; other site 373903007151 alpha-mannosidase; Provisional; Region: PRK09819 373903007152 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 373903007153 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 373903007154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903007155 dimer interface [polypeptide binding]; other site 373903007156 conserved gate region; other site 373903007157 putative PBP binding loops; other site 373903007158 ABC-ATPase subunit interface; other site 373903007159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373903007160 dimer interface [polypeptide binding]; other site 373903007161 conserved gate region; other site 373903007162 putative PBP binding loops; other site 373903007163 ABC-ATPase subunit interface; other site 373903007164 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373903007165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373903007166 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373903007167 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373903007168 DNA binding site [nucleotide binding] 373903007169 domain linker motif; other site 373903007170 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 373903007171 dimerization interface [polypeptide binding]; other site 373903007172 ligand binding site [chemical binding]; other site 373903007173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373903007174 Zn2+ binding site [ion binding]; other site 373903007175 Mg2+ binding site [ion binding]; other site 373903007176 CotJB protein; Region: CotJB; pfam12652 373903007177 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 373903007178 dimanganese center [ion binding]; other site 373903007179 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 373903007180 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373903007181 dimer interface [polypeptide binding]; other site 373903007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903007183 catalytic residue [active] 373903007184 serine O-acetyltransferase; Region: cysE; TIGR01172 373903007185 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 373903007186 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373903007187 trimer interface [polypeptide binding]; other site 373903007188 active site 373903007189 substrate binding site [chemical binding]; other site 373903007190 CoA binding site [chemical binding]; other site 373903007191 AIR carboxylase; Region: AIRC; cl00310 373903007192 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 373903007193 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 373903007194 ATP-grasp domain; Region: ATP-grasp_4; cl03087 373903007195 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 373903007196 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 373903007197 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 373903007198 GDP-binding site [chemical binding]; other site 373903007199 ACT binding site; other site 373903007200 IMP binding site; other site 373903007201 adenylosuccinate lyase; Provisional; Region: PRK07380 373903007202 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 373903007203 tetramer interface [polypeptide binding]; other site 373903007204 active site 373903007205 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 373903007206 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 373903007207 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 373903007208 DNA replication protein DnaC; Validated; Region: PRK06835 373903007209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903007210 Walker A motif; other site 373903007211 ATP binding site [chemical binding]; other site 373903007212 Walker B motif; other site 373903007213 arginine finger; other site 373903007214 replicative DNA helicase; Region: DnaB; TIGR00665 373903007215 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373903007216 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 373903007217 Walker A motif; other site 373903007218 ATP binding site [chemical binding]; other site 373903007219 Walker B motif; other site 373903007220 DNA binding loops [nucleotide binding] 373903007221 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 373903007222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373903007223 FeS/SAM binding site; other site 373903007224 Pyruvate formate lyase 1; Region: PFL1; cd01678 373903007225 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 373903007226 coenzyme A binding site [chemical binding]; other site 373903007227 active site 373903007228 catalytic residues [active] 373903007229 glycine loop; other site 373903007230 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 373903007231 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 373903007232 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 373903007233 Ca binding site [ion binding]; other site 373903007234 active site 373903007235 catalytic site [active] 373903007236 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 373903007237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903007238 FtsX-like permease family; Region: FtsX; cl15850 373903007239 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903007240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 373903007241 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 373903007242 Walker A/P-loop; other site 373903007243 ATP binding site [chemical binding]; other site 373903007244 Q-loop/lid; other site 373903007245 ABC transporter signature motif; other site 373903007246 Walker B; other site 373903007247 D-loop; other site 373903007248 H-loop/switch region; other site 373903007249 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 373903007250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903007251 FtsX-like permease family; Region: FtsX; cl15850 373903007252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373903007253 FtsX-like permease family; Region: FtsX; cl15850 373903007254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373903007255 Helix-turn-helix domains; Region: HTH; cl00088 373903007256 Cupin domain; Region: Cupin_2; cl09118 373903007257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903007258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373903007259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373903007260 alpha-galactosidase; Provisional; Region: PRK15076 373903007261 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 373903007262 NAD binding site [chemical binding]; other site 373903007263 sugar binding site [chemical binding]; other site 373903007264 divalent metal binding site [ion binding]; other site 373903007265 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 373903007266 dimer interface [polypeptide binding]; other site 373903007267 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 373903007268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373903007269 Walker A motif; other site 373903007270 ATP binding site [chemical binding]; other site 373903007271 Walker B motif; other site 373903007272 arginine finger; other site 373903007273 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 373903007274 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 373903007275 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 373903007276 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 373903007277 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 373903007278 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 373903007279 dimer interface [polypeptide binding]; other site 373903007280 ssDNA binding site [nucleotide binding]; other site 373903007281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373903007282 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 373903007283 GTP-binding protein YchF; Reviewed; Region: PRK09601 373903007284 YchF GTPase; Region: YchF; cd01900 373903007285 G1 box; other site 373903007286 GTP/Mg2+ binding site [chemical binding]; other site 373903007287 Switch I region; other site 373903007288 G2 box; other site 373903007289 Switch II region; other site 373903007290 G3 box; other site 373903007291 G4 box; other site 373903007292 G5 box; other site 373903007293 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 373903007294 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 373903007295 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373903007296 Tetratricopeptide repeat; Region: TPR_16; pfam13432 373903007297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373903007298 binding surface 373903007299 TPR motif; other site 373903007300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 373903007301 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 373903007302 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373903007303 tetramer interface [polypeptide binding]; other site 373903007304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903007305 catalytic residue [active] 373903007306 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 373903007307 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373903007308 tetramer interface [polypeptide binding]; other site 373903007309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373903007310 catalytic residue [active] 373903007311 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 373903007312 lipoyl attachment site [posttranslational modification]; other site 373903007313 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 373903007314 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 373903007315 Uncharacterized membrane protein [Function unknown]; Region: COG3949 373903007316 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 373903007317 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 373903007318 Peptidase family M23; Region: Peptidase_M23; pfam01551 373903007319 PrcB C-terminal; Region: PrcB_C; pfam14343 373903007320 Protein of unknown function (DUF554); Region: DUF554; cl00784 373903007321 ParB-like partition proteins; Region: parB_part; TIGR00180 373903007322 ParB-like nuclease domain; Region: ParBc; cl02129 373903007323 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 373903007324 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373903007325 P-loop; other site 373903007326 Magnesium ion binding site [ion binding]; other site 373903007327 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 373903007328 Magnesium ion binding site [ion binding]; other site 373903007329 ParB-like partition proteins; Region: parB_part; TIGR00180 373903007330 ParB-like nuclease domain; Region: ParBc; cl02129 373903007331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 373903007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 373903007333 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 373903007334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373903007335 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 373903007336 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 373903007337 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 373903007338 trmE is a tRNA modification GTPase; Region: trmE; cd04164 373903007339 G1 box; other site 373903007340 GTP/Mg2+ binding site [chemical binding]; other site 373903007341 Switch I region; other site 373903007342 G2 box; other site 373903007343 Switch II region; other site 373903007344 G3 box; other site 373903007345 G4 box; other site 373903007346 G5 box; other site 373903007347 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 373903007348 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 373903007349 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 373903007350 G-X-X-G motif; other site 373903007351 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 373903007352 RxxxH motif; other site 373903007353 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 373903007354 Haemolytic domain; Region: Haemolytic; cl00506 373903007355 Ribonuclease P; Region: Ribonuclease_P; cl00457