-- dump date 20120504_150128 -- class Genbank::misc_feature -- table misc_feature_note -- id note 592205000001 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 592205000002 putative RNA binding site [nucleotide binding]; other site 592205000003 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 592205000004 homopentamer interface [polypeptide binding]; other site 592205000005 active site 592205000006 NeuB family; Region: NeuB; cl00496 592205000007 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 592205000008 active site clefts [active] 592205000009 zinc binding site [ion binding]; other site 592205000010 dimer interface [polypeptide binding]; other site 592205000011 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 592205000012 active site 592205000013 dimer interface [polypeptide binding]; other site 592205000014 pantoate--beta-alanine ligase; Region: panC; TIGR00018 592205000015 Pantoate-beta-alanine ligase; Region: PanC; cd00560 592205000016 active site 592205000017 ATP-binding site [chemical binding]; other site 592205000018 pantoate-binding site; other site 592205000019 HXXH motif; other site 592205000020 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000021 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 592205000022 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 592205000023 ring oligomerisation interface [polypeptide binding]; other site 592205000024 ATP/Mg binding site [chemical binding]; other site 592205000025 stacking interactions; other site 592205000026 hinge regions; other site 592205000027 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 592205000028 oligomerisation interface [polypeptide binding]; other site 592205000029 mobile loop; other site 592205000030 roof hairpin; other site 592205000031 DNA primase, catalytic core; Region: dnaG; TIGR01391 592205000032 CHC2 zinc finger; Region: zf-CHC2; cl15369 592205000033 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 592205000034 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 592205000035 active site 592205000036 metal binding site [ion binding]; metal-binding site 592205000037 interdomain interaction site; other site 592205000038 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 592205000039 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 592205000040 Ligand Binding Site [chemical binding]; other site 592205000041 TrbC/VIRB2 family; Region: TrbC; cl01583 592205000042 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 592205000043 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 592205000044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000045 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 592205000046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 592205000047 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 592205000048 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592205000049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205000050 active site 592205000051 phosphorylation site [posttranslational modification] 592205000052 intermolecular recognition site; other site 592205000053 dimerization interface [polypeptide binding]; other site 592205000054 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 592205000055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 592205000056 dimer interface [polypeptide binding]; other site 592205000057 active site 592205000058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592205000059 catalytic residues [active] 592205000060 substrate binding site [chemical binding]; other site 592205000061 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592205000062 active site 592205000063 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 592205000064 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 592205000065 Sulfatase; Region: Sulfatase; cl10460 592205000066 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000067 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 592205000068 dimer interface [polypeptide binding]; other site 592205000069 Citrate synthase; Region: Citrate_synt; pfam00285 592205000070 active site 592205000071 citrylCoA binding site [chemical binding]; other site 592205000072 NADH binding [chemical binding]; other site 592205000073 cationic pore residues; other site 592205000074 oxalacetate/citrate binding site [chemical binding]; other site 592205000075 coenzyme A binding site [chemical binding]; other site 592205000076 catalytic triad [active] 592205000077 isocitrate dehydrogenase; Validated; Region: PRK07362 592205000078 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 592205000079 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 592205000080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000081 AAA domain; Region: AAA_26; pfam13500 592205000082 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592205000083 Ligand Binding Site [chemical binding]; other site 592205000084 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 592205000085 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 592205000086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000087 Walker A motif; other site 592205000088 ATP binding site [chemical binding]; other site 592205000089 Walker B motif; other site 592205000090 arginine finger; other site 592205000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000092 Walker A motif; other site 592205000093 ATP binding site [chemical binding]; other site 592205000094 Walker B motif; other site 592205000095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 592205000096 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 592205000097 tetramerization interface [polypeptide binding]; other site 592205000098 active site 592205000099 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 592205000100 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 592205000101 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 592205000102 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 592205000103 VirB8 protein; Region: VirB8; cl01500 592205000104 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 592205000105 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 592205000106 VirB7 interaction site; other site 592205000107 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 592205000108 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 592205000109 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 592205000110 Substrate binding site; other site 592205000111 Cupin domain; Region: Cupin_2; cl09118 592205000112 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 592205000113 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 592205000114 NADP-binding site; other site 592205000115 homotetramer interface [polypeptide binding]; other site 592205000116 substrate binding site [chemical binding]; other site 592205000117 homodimer interface [polypeptide binding]; other site 592205000118 active site 592205000119 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 592205000120 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 592205000121 NADP binding site [chemical binding]; other site 592205000122 active site 592205000123 putative substrate binding site [chemical binding]; other site 592205000124 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 592205000125 dimerization interface [polypeptide binding]; other site 592205000126 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 592205000127 ATP binding site [chemical binding]; other site 592205000128 Acylphosphatase; Region: Acylphosphatase; cl00551 592205000129 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 592205000130 HypF finger; Region: zf-HYPF; pfam07503 592205000131 HypF finger; Region: zf-HYPF; pfam07503 592205000132 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 592205000133 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 592205000134 agmatine deiminase; Region: agmatine_aguA; TIGR03380 592205000135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000136 Sodium:solute symporter family; Region: SSF; cl00456 592205000137 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592205000138 Proline dehydrogenase; Region: Pro_dh; cl03282 592205000139 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 592205000140 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592205000141 Glutamate binding site [chemical binding]; other site 592205000142 NAD binding site [chemical binding]; other site 592205000143 catalytic residues [active] 592205000144 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 592205000145 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 592205000146 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 592205000147 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 592205000148 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 592205000149 UreD urease accessory protein; Region: UreD; cl00530 592205000150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000151 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 592205000152 UreF; Region: UreF; pfam01730 592205000153 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 592205000154 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 592205000155 dimer interface [polypeptide binding]; other site 592205000156 catalytic residues [active] 592205000157 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 592205000158 urease subunit beta; Provisional; Region: ureB; PRK13985 592205000159 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 592205000160 subunit interactions [polypeptide binding]; other site 592205000161 active site 592205000162 flap region; other site 592205000163 urease subunit alpha; Provisional; Region: PRK13986 592205000164 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 592205000165 alpha-gamma subunit interface [polypeptide binding]; other site 592205000166 beta-gamma subunit interface [polypeptide binding]; other site 592205000167 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 592205000168 gamma-beta subunit interface [polypeptide binding]; other site 592205000169 alpha-beta subunit interface [polypeptide binding]; other site 592205000170 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 592205000171 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 592205000172 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 592205000173 active site 592205000174 substrate binding site [chemical binding]; other site 592205000175 metal binding site [ion binding]; metal-binding site 592205000176 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 592205000177 peptide chain release factor 1; Validated; Region: prfA; PRK00591 592205000178 RF-1 domain; Region: RF-1; cl02875 592205000179 RF-1 domain; Region: RF-1; cl02875 592205000180 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592205000181 dimer interface [polypeptide binding]; other site 592205000182 putative CheW interface [polypeptide binding]; other site 592205000183 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 592205000184 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 592205000185 23S rRNA interface [nucleotide binding]; other site 592205000186 L3 interface [polypeptide binding]; other site 592205000187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000188 Predicted dehydrogenase [General function prediction only]; Region: COG0579 592205000189 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 592205000190 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 592205000191 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 592205000192 NlpC/P60 family; Region: NLPC_P60; cl11438 592205000193 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 592205000194 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 592205000195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592205000196 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592205000197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592205000198 DNA binding residues [nucleotide binding] 592205000199 5'-methylthioadenosine nucleosidase; Region: PLN02584 592205000200 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 592205000201 Acyl transferase domain; Region: Acyl_transf_1; cl08282 592205000202 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592205000203 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 592205000204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000205 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 592205000206 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 592205000207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000208 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 592205000209 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 592205000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205000211 catalytic residue [active] 592205000212 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 592205000213 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592205000214 dimer interface [polypeptide binding]; other site 592205000215 putative CheW interface [polypeptide binding]; other site 592205000216 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 592205000217 Ligand Binding Site [chemical binding]; other site 592205000218 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000219 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 592205000220 metal-binding site 592205000221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 592205000222 Cache domain; Region: Cache_2; cl07034 592205000223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 592205000224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592205000225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592205000226 dimer interface [polypeptide binding]; other site 592205000227 putative CheW interface [polypeptide binding]; other site 592205000228 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 592205000229 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 592205000230 active site 592205000231 metal binding site [ion binding]; metal-binding site 592205000232 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592205000233 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 592205000234 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 592205000235 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592205000236 homodimer interface [polypeptide binding]; other site 592205000237 substrate-cofactor binding pocket; other site 592205000238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205000239 catalytic residue [active] 592205000240 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592205000241 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592205000242 dimer interface [polypeptide binding]; other site 592205000243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205000244 catalytic residue [active] 592205000245 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 592205000246 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 592205000247 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 592205000248 dimer interface [polypeptide binding]; other site 592205000249 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 592205000250 heat-inducible transcription repressor; Provisional; Region: PRK03911 592205000251 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 592205000252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 592205000253 flagellin B; Provisional; Region: PRK13588 592205000254 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592205000255 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 592205000256 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 592205000257 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592205000258 DNA topoisomerase I; Validated; Region: PRK05582 592205000259 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 592205000260 active site 592205000261 interdomain interaction site; other site 592205000262 putative metal-binding site [ion binding]; other site 592205000263 nucleotide binding site [chemical binding]; other site 592205000264 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592205000265 domain I; other site 592205000266 DNA binding groove [nucleotide binding] 592205000267 phosphate binding site [ion binding]; other site 592205000268 domain II; other site 592205000269 domain III; other site 592205000270 nucleotide binding site [chemical binding]; other site 592205000271 catalytic site [active] 592205000272 domain IV; other site 592205000273 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592205000274 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592205000275 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592205000276 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 592205000277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205000278 FeS/SAM binding site; other site 592205000279 phosphoenolpyruvate synthase; Validated; Region: PRK06464 592205000280 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 592205000281 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 592205000282 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 592205000283 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 592205000284 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 592205000285 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 592205000286 active site 592205000287 dimer interface [polypeptide binding]; other site 592205000288 motif 1; other site 592205000289 motif 2; other site 592205000290 motif 3; other site 592205000291 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 592205000292 anticodon binding site; other site 592205000293 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 592205000294 translation initiation factor IF-3; Region: infC; TIGR00168 592205000295 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 592205000296 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 592205000297 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 592205000298 23S rRNA binding site [nucleotide binding]; other site 592205000299 L21 binding site [polypeptide binding]; other site 592205000300 L13 binding site [polypeptide binding]; other site 592205000301 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000302 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 592205000303 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 592205000304 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 592205000305 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 592205000306 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 592205000307 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 592205000308 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 592205000309 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 592205000310 catalytic triad [active] 592205000311 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 592205000312 iron-sulfur cluster-binding protein; Region: TIGR00273 592205000313 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 592205000314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592205000315 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 592205000316 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 592205000317 Cysteine-rich domain; Region: CCG; pfam02754 592205000318 Cysteine-rich domain; Region: CCG; pfam02754 592205000319 L-lactate permease; Region: Lactate_perm; cl00701 592205000320 glycolate transporter; Provisional; Region: PRK09695 592205000321 glycolate transporter; Provisional; Region: PRK09695 592205000322 L-lactate permease; Region: Lactate_perm; cl00701 592205000323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592205000324 DNA glycosylase MutY; Provisional; Region: PRK13910 592205000325 minor groove reading motif; other site 592205000326 helix-hairpin-helix signature motif; other site 592205000327 substrate binding pocket [chemical binding]; other site 592205000328 active site 592205000329 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 592205000330 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592205000331 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 592205000332 transmembrane helices; other site 592205000333 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 592205000334 Low-spin heme binding site [chemical binding]; other site 592205000335 D-pathway; other site 592205000336 Putative water exit pathway; other site 592205000337 Binuclear center (active site) [active] 592205000338 K-pathway; other site 592205000339 Putative proton exit pathway; other site 592205000340 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 592205000341 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 592205000342 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 592205000343 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 592205000344 Cytochrome c; Region: Cytochrom_C; cl11414 592205000345 Cytochrome c; Region: Cytochrom_C; cl11414 592205000346 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 592205000347 NMT1-like family; Region: NMT1_2; cl15260 592205000348 recombinase A; Provisional; Region: recA; PRK09354 592205000349 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 592205000350 hexamer interface [polypeptide binding]; other site 592205000351 Walker A motif; other site 592205000352 ATP binding site [chemical binding]; other site 592205000353 Walker B motif; other site 592205000354 enolase; Provisional; Region: eno; PRK00077 592205000355 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 592205000356 dimer interface [polypeptide binding]; other site 592205000357 metal binding site [ion binding]; metal-binding site 592205000358 substrate binding pocket [chemical binding]; other site 592205000359 AMIN domain; Region: AMIN; pfam11741 592205000360 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 592205000361 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 592205000362 ADP binding site [chemical binding]; other site 592205000363 magnesium binding site [ion binding]; other site 592205000364 putative shikimate binding site; other site 592205000365 Cache domain; Region: Cache_1; pfam02743 592205000366 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 592205000367 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 592205000368 Ligand binding site; other site 592205000369 metal-binding site 592205000370 Sel1 repeat; Region: Sel1; cl02723 592205000371 Sel1 repeat; Region: Sel1; cl02723 592205000372 Sel1 repeat; Region: Sel1; cl02723 592205000373 Sel1 repeat; Region: Sel1; cl02723 592205000374 Sel1 repeat; Region: Sel1; cl02723 592205000375 Sel1 repeat; Region: Sel1; cl02723 592205000376 Transcriptional regulator; Region: Transcrip_reg; cl00361 592205000377 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 592205000378 dimer interface [polypeptide binding]; other site 592205000379 active site 592205000380 Schiff base residues; other site 592205000381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 592205000382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592205000383 dimer interface [polypeptide binding]; other site 592205000384 phosphorylation site [posttranslational modification] 592205000385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592205000386 ATP binding site [chemical binding]; other site 592205000387 Mg2+ binding site [ion binding]; other site 592205000388 G-X-G motif; other site 592205000389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592205000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205000391 active site 592205000392 phosphorylation site [posttranslational modification] 592205000393 intermolecular recognition site; other site 592205000394 dimerization interface [polypeptide binding]; other site 592205000395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592205000396 DNA binding site [nucleotide binding] 592205000397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592205000398 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 592205000399 Peptidase family U32; Region: Peptidase_U32; cl03113 592205000400 peptide chain release factor 2; Region: prfB; TIGR00020 592205000401 RF-1 domain; Region: RF-1; cl02875 592205000402 RF-1 domain; Region: RF-1; cl02875 592205000403 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 592205000404 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 592205000405 dimer interface [polypeptide binding]; other site 592205000406 putative functional site; other site 592205000407 putative MPT binding site; other site 592205000408 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 592205000409 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 592205000410 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 592205000411 PPIC-type PPIASE domain; Region: Rotamase; cl08278 592205000412 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592205000413 hypothetical protein; Provisional; Region: PRK08185 592205000414 intersubunit interface [polypeptide binding]; other site 592205000415 active site 592205000416 zinc binding site [ion binding]; other site 592205000417 Na+ binding site [ion binding]; other site 592205000418 elongation factor P; Validated; Region: PRK00529 592205000419 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 592205000420 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 592205000421 RNA binding site [nucleotide binding]; other site 592205000422 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 592205000423 RNA binding site [nucleotide binding]; other site 592205000424 pseudaminic acid synthase; Region: PseI; TIGR03586 592205000425 NeuB family; Region: NeuB; cl00496 592205000426 SAF domain; Region: SAF; cl00555 592205000427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592205000428 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 592205000429 Walker A/P-loop; other site 592205000430 ATP binding site [chemical binding]; other site 592205000431 Q-loop/lid; other site 592205000432 ABC transporter signature motif; other site 592205000433 Walker B; other site 592205000434 D-loop; other site 592205000435 H-loop/switch region; other site 592205000436 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 592205000437 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 592205000438 active site 592205000439 catalytic triad [active] 592205000440 Colicin V production protein; Region: Colicin_V; cl00567 592205000441 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 592205000442 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 592205000443 dimer interface [polypeptide binding]; other site 592205000444 putative anticodon binding site; other site 592205000445 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 592205000446 motif 1; other site 592205000447 active site 592205000448 motif 2; other site 592205000449 motif 3; other site 592205000450 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 592205000451 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 592205000452 dimer interface [polypeptide binding]; other site 592205000453 glycine-pyridoxal phosphate binding site [chemical binding]; other site 592205000454 active site 592205000455 folate binding site [chemical binding]; other site 592205000456 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 592205000457 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 592205000458 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 592205000459 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 592205000460 putative active site [active] 592205000461 catalytic site [active] 592205000462 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 592205000463 PLD-like domain; Region: PLDc_2; pfam13091 592205000464 putative active site [active] 592205000465 catalytic site [active] 592205000466 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 592205000467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 592205000468 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592205000469 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 592205000470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000471 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592205000472 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 592205000473 Iron-sulfur protein interface; other site 592205000474 proximal heme binding site [chemical binding]; other site 592205000475 distal heme binding site [chemical binding]; other site 592205000476 dimer interface [polypeptide binding]; other site 592205000477 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 592205000478 substrate binding site [chemical binding]; other site 592205000479 dimer interface [polypeptide binding]; other site 592205000480 catalytic triad [active] 592205000481 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 592205000482 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 592205000483 NAD binding site [chemical binding]; other site 592205000484 homotetramer interface [polypeptide binding]; other site 592205000485 homodimer interface [polypeptide binding]; other site 592205000486 substrate binding site [chemical binding]; other site 592205000487 active site 592205000488 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 592205000489 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 592205000490 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 592205000491 trimer interface [polypeptide binding]; other site 592205000492 active site 592205000493 UDP-GlcNAc binding site [chemical binding]; other site 592205000494 lipid binding site [chemical binding]; lipid-binding site 592205000495 S-adenosylmethionine synthetase; Validated; Region: PRK05250 592205000496 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 592205000497 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 592205000498 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 592205000499 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 592205000500 active site 592205000501 multimer interface [polypeptide binding]; other site 592205000502 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 592205000503 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 592205000504 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 592205000505 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592205000506 dimer interface [polypeptide binding]; other site 592205000507 active site 592205000508 CoA binding pocket [chemical binding]; other site 592205000509 antiporter inner membrane protein; Provisional; Region: PRK11670 592205000510 Domain of unknown function DUF59; Region: DUF59; cl00941 592205000511 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 592205000512 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 592205000513 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 592205000514 Ligand binding site; other site 592205000515 metal-binding site 592205000516 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205000517 heat shock protein 90; Provisional; Region: PRK05218 592205000518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 592205000519 TPR repeat; Region: TPR_11; pfam13414 592205000520 Sel1 repeat; Region: Sel1; cl02723 592205000521 Sel1 repeat; Region: Sel1; cl02723 592205000522 Sel1 repeat; Region: Sel1; cl02723 592205000523 Sel1 repeat; Region: Sel1; cl02723 592205000524 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 592205000525 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 592205000526 metal binding site [ion binding]; metal-binding site 592205000527 dimer interface [polypeptide binding]; other site 592205000528 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 592205000529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592205000530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000531 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 592205000532 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592205000533 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 592205000534 transmembrane helices; other site 592205000535 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 592205000536 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 592205000537 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 592205000538 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 592205000539 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 592205000540 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 592205000541 substrate binding site [chemical binding]; other site 592205000542 Helix-turn-helix domains; Region: HTH; cl00088 592205000543 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592205000544 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 592205000545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592205000546 catalytic residue [active] 592205000547 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 592205000548 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 592205000549 trimerization site [polypeptide binding]; other site 592205000550 active site 592205000551 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 592205000552 NifU-like domain; Region: NifU; cl00484 592205000553 DNA repair protein RadA; Region: sms; TIGR00416 592205000554 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 592205000555 Walker A motif/ATP binding site; other site 592205000556 ATP binding site [chemical binding]; other site 592205000557 Walker B motif; other site 592205000558 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 592205000559 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 592205000560 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 592205000561 SelR domain; Region: SelR; pfam01641 592205000562 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 592205000563 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000564 Sulfate transporter family; Region: Sulfate_transp; cl15842 592205000565 Sulfate transporter family; Region: Sulfate_transp; cl15842 592205000566 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000567 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 592205000568 Ligand binding site; other site 592205000569 oligomer interface; other site 592205000570 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 592205000571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592205000572 hypothetical protein; Provisional; Region: PRK04081 592205000573 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 592205000574 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 592205000575 Sel1 repeat; Region: Sel1; cl02723 592205000576 Sel1 repeat; Region: Sel1; cl02723 592205000577 Sel1 repeat; Region: Sel1; cl02723 592205000578 Sel1 repeat; Region: Sel1; cl02723 592205000579 Sel1 repeat; Region: Sel1; cl02723 592205000580 Cytochrome c; Region: Cytochrom_C; cl11414 592205000581 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 592205000582 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 592205000583 domain interfaces; other site 592205000584 active site 592205000585 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 592205000586 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 592205000587 dimer interface [polypeptide binding]; other site 592205000588 motif 1; other site 592205000589 active site 592205000590 motif 2; other site 592205000591 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 592205000592 putative deacylase active site [active] 592205000593 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 592205000594 active site 592205000595 motif 3; other site 592205000596 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 592205000597 anticodon binding site; other site 592205000598 glutamyl-tRNA reductase; Region: hemA; TIGR01035 592205000599 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 592205000600 tRNA; other site 592205000601 putative tRNA binding site [nucleotide binding]; other site 592205000602 putative NADP binding site [chemical binding]; other site 592205000603 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 592205000604 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592205000605 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592205000606 substrate binding pocket [chemical binding]; other site 592205000607 chain length determination region; other site 592205000608 substrate-Mg2+ binding site; other site 592205000609 catalytic residues [active] 592205000610 aspartate-rich region 1; other site 592205000611 active site lid residues [active] 592205000612 aspartate-rich region 2; other site 592205000613 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 592205000614 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 592205000615 Ferritin-like domain; Region: Ferritin; pfam00210 592205000616 dimerization interface [polypeptide binding]; other site 592205000617 DPS ferroxidase diiron center [ion binding]; other site 592205000618 ion pore; other site 592205000619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592205000620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592205000621 dimer interface [polypeptide binding]; other site 592205000622 phosphorylation site [posttranslational modification] 592205000623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592205000624 ATP binding site [chemical binding]; other site 592205000625 Mg2+ binding site [ion binding]; other site 592205000626 G-X-G motif; other site 592205000627 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 592205000628 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 592205000629 helicase 45; Provisional; Region: PTZ00424 592205000630 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592205000631 ATP binding site [chemical binding]; other site 592205000632 Mg++ binding site [ion binding]; other site 592205000633 motif III; other site 592205000634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592205000635 nucleotide binding region [chemical binding]; other site 592205000636 ATP-binding site [chemical binding]; other site 592205000637 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592205000638 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 592205000639 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 592205000640 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592205000641 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 592205000642 Walker A/P-loop; other site 592205000643 ATP binding site [chemical binding]; other site 592205000644 Q-loop/lid; other site 592205000645 ABC transporter signature motif; other site 592205000646 Walker B; other site 592205000647 D-loop; other site 592205000648 H-loop/switch region; other site 592205000649 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 592205000650 Walker A/P-loop; other site 592205000651 ATP binding site [chemical binding]; other site 592205000652 Q-loop/lid; other site 592205000653 ABC transporter signature motif; other site 592205000654 Walker B; other site 592205000655 D-loop; other site 592205000656 H-loop/switch region; other site 592205000657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592205000658 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000659 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000660 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 592205000661 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 592205000662 GDP-binding site [chemical binding]; other site 592205000663 ACT binding site; other site 592205000664 IMP binding site; other site 592205000665 MgtE intracellular N domain; Region: MgtE_N; cl15244 592205000666 RIP metalloprotease RseP; Region: TIGR00054 592205000667 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592205000668 active site 592205000669 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592205000670 protein binding site [polypeptide binding]; other site 592205000671 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 592205000672 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 592205000673 generic binding surface II; other site 592205000674 generic binding surface I; other site 592205000675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000678 Clp amino terminal domain; Region: Clp_N; pfam02861 592205000679 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 592205000680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000681 Walker A motif; other site 592205000682 ATP binding site [chemical binding]; other site 592205000683 Walker B motif; other site 592205000684 arginine finger; other site 592205000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000686 Walker A motif; other site 592205000687 ATP binding site [chemical binding]; other site 592205000688 Walker B motif; other site 592205000689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 592205000690 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 592205000691 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 592205000692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592205000693 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592205000694 active site 592205000695 chlorohydrolase; Provisional; Region: PRK08418 592205000696 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 592205000697 active site 592205000698 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592205000699 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 592205000700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205000701 FeS/SAM binding site; other site 592205000702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 592205000703 putative acyl-acceptor binding pocket; other site 592205000704 Flagellin N-methylase; Region: FliB; cl00497 592205000705 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 592205000706 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 592205000707 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 592205000708 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 592205000709 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 592205000710 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592205000711 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 592205000712 putative active site [active] 592205000713 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 592205000714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 592205000715 putative acyl-acceptor binding pocket; other site 592205000716 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 592205000717 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 592205000718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 592205000719 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 592205000720 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 592205000721 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 592205000722 active site 592205000723 dimer interface [polypeptide binding]; other site 592205000724 metal binding site [ion binding]; metal-binding site 592205000725 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592205000726 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592205000727 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 592205000728 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592205000729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205000730 FeS/SAM binding site; other site 592205000731 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 592205000732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000733 Walker A motif; other site 592205000734 ATP binding site [chemical binding]; other site 592205000735 Walker B motif; other site 592205000736 arginine finger; other site 592205000737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592205000738 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 592205000739 Vacuolating cyotoxin; Region: VacA; pfam02691 592205000740 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205000741 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205000742 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 592205000743 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205000744 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 592205000745 diaminopimelate decarboxylase; Region: lysA; TIGR01048 592205000746 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 592205000747 active site 592205000748 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592205000749 substrate binding site [chemical binding]; other site 592205000750 catalytic residues [active] 592205000751 dimer interface [polypeptide binding]; other site 592205000752 Chorismate mutase type II; Region: CM_2; cl00693 592205000753 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 592205000754 aminodeoxychorismate synthase; Provisional; Region: PRK07508 592205000755 chorismate binding enzyme; Region: Chorismate_bind; cl10555 592205000756 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 592205000757 substrate-cofactor binding pocket; other site 592205000758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205000759 catalytic residue [active] 592205000760 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 592205000761 multimer interface [polypeptide binding]; other site 592205000762 active site 592205000763 catalytic triad [active] 592205000764 dimer interface [polypeptide binding]; other site 592205000765 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 592205000766 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592205000767 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 592205000768 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 592205000769 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 592205000770 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 592205000771 peptide binding site [polypeptide binding]; other site 592205000772 dipeptide transporter permease DppB; Provisional; Region: PRK10914 592205000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205000774 dimer interface [polypeptide binding]; other site 592205000775 conserved gate region; other site 592205000776 putative PBP binding loops; other site 592205000777 ABC-ATPase subunit interface; other site 592205000778 dipeptide transporter; Provisional; Region: PRK10913 592205000779 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592205000780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205000781 dimer interface [polypeptide binding]; other site 592205000782 conserved gate region; other site 592205000783 putative PBP binding loops; other site 592205000784 ABC-ATPase subunit interface; other site 592205000785 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 592205000786 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 592205000787 Walker A/P-loop; other site 592205000788 ATP binding site [chemical binding]; other site 592205000789 Q-loop/lid; other site 592205000790 ABC transporter signature motif; other site 592205000791 Walker B; other site 592205000792 D-loop; other site 592205000793 H-loop/switch region; other site 592205000794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592205000795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592205000796 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 592205000797 Walker A/P-loop; other site 592205000798 ATP binding site [chemical binding]; other site 592205000799 Q-loop/lid; other site 592205000800 ABC transporter signature motif; other site 592205000801 Walker B; other site 592205000802 D-loop; other site 592205000803 H-loop/switch region; other site 592205000804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592205000805 GTPase CgtA; Reviewed; Region: obgE; PRK12299 592205000806 GTP1/OBG; Region: GTP1_OBG; pfam01018 592205000807 Obg GTPase; Region: Obg; cd01898 592205000808 G1 box; other site 592205000809 GTP/Mg2+ binding site [chemical binding]; other site 592205000810 Switch I region; other site 592205000811 G2 box; other site 592205000812 G3 box; other site 592205000813 Switch II region; other site 592205000814 G4 box; other site 592205000815 G5 box; other site 592205000816 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 592205000817 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 592205000818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592205000819 inhibitor-cofactor binding pocket; inhibition site 592205000820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205000821 catalytic residue [active] 592205000822 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 592205000823 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592205000824 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 592205000825 active site 592205000826 catalytic triad [active] 592205000827 dimer interface [polypeptide binding]; other site 592205000828 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592205000829 active site 592205000830 catalytic site [active] 592205000831 Zn binding site [ion binding]; other site 592205000832 tetramer interface [polypeptide binding]; other site 592205000833 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592205000834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000835 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 592205000836 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592205000837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592205000838 putative substrate translocation pore; other site 592205000839 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 592205000840 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 592205000841 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 592205000842 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 592205000843 arginyl-tRNA synthetase; Region: argS; TIGR00456 592205000844 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 592205000845 active site 592205000846 HIGH motif; other site 592205000847 KMSK motif region; other site 592205000848 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 592205000849 tRNA binding surface [nucleotide binding]; other site 592205000850 anticodon binding site; other site 592205000851 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 592205000852 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 592205000853 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 592205000854 catalytic site [active] 592205000855 G-X2-G-X-G-K; other site 592205000856 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 592205000857 nuclease NucT; Provisional; Region: PRK13912 592205000858 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 592205000859 putative active site [active] 592205000860 catalytic site [active] 592205000861 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205000862 Flagellar L-ring protein; Region: FlgH; cl00905 592205000863 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 592205000864 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 592205000865 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 592205000866 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 592205000867 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 592205000868 NAD synthase; Region: NAD_synthase; pfam02540 592205000869 homodimer interface [polypeptide binding]; other site 592205000870 NAD binding pocket [chemical binding]; other site 592205000871 ATP binding pocket [chemical binding]; other site 592205000872 Mg binding site [ion binding]; other site 592205000873 active-site loop [active] 592205000874 ketol-acid reductoisomerase; Provisional; Region: PRK05479 592205000875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000876 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 592205000877 septum site-determining protein MinD; Region: minD_bact; TIGR01968 592205000878 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 592205000879 Switch I; other site 592205000880 Switch II; other site 592205000881 Septum formation topological specificity factor MinE; Region: MinE; cl00538 592205000882 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 592205000883 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 592205000884 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 592205000885 Sel1 repeat; Region: Sel1; cl02723 592205000886 Sel1 repeat; Region: Sel1; cl02723 592205000887 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 592205000888 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592205000889 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 592205000890 active site 592205000891 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 592205000892 DHH family; Region: DHH; pfam01368 592205000893 DHHA1 domain; Region: DHHA1; pfam02272 592205000894 CTP synthetase; Validated; Region: pyrG; PRK05380 592205000895 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 592205000896 Catalytic site [active] 592205000897 active site 592205000898 UTP binding site [chemical binding]; other site 592205000899 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 592205000900 active site 592205000901 putative oxyanion hole; other site 592205000902 catalytic triad [active] 592205000903 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592205000904 active site 592205000905 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 592205000906 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 592205000907 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 592205000908 flagellar motor switch protein FliG; Region: fliG; TIGR00207 592205000909 FliG C-terminal domain; Region: FliG_C; pfam01706 592205000910 flagellar assembly protein H; Validated; Region: fliH; PRK06669 592205000911 Flagellar assembly protein FliH; Region: FliH; pfam02108 592205000912 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 592205000913 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 592205000914 TPP-binding site; other site 592205000915 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592205000916 PYR/PP interface [polypeptide binding]; other site 592205000917 dimer interface [polypeptide binding]; other site 592205000918 TPP binding site [chemical binding]; other site 592205000919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592205000920 GTP-binding protein LepA; Provisional; Region: PRK05433 592205000921 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 592205000922 G1 box; other site 592205000923 putative GEF interaction site [polypeptide binding]; other site 592205000924 GTP/Mg2+ binding site [chemical binding]; other site 592205000925 Switch I region; other site 592205000926 G2 box; other site 592205000927 G3 box; other site 592205000928 Switch II region; other site 592205000929 G4 box; other site 592205000930 G5 box; other site 592205000931 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 592205000932 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 592205000933 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 592205000934 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 592205000935 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 592205000936 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205000937 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 592205000938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592205000939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592205000940 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 592205000941 TspO/MBR family; Region: TspO_MBR; cl01379 592205000942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000943 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 592205000944 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 592205000945 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 592205000946 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 592205000947 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592205000948 TPP-binding site [chemical binding]; other site 592205000949 dimer interface [polypeptide binding]; other site 592205000950 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592205000951 PYR/PP interface [polypeptide binding]; other site 592205000952 dimer interface [polypeptide binding]; other site 592205000953 TPP binding site [chemical binding]; other site 592205000954 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592205000955 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 592205000956 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 592205000957 active site 592205000958 Riboflavin kinase; Region: Flavokinase; cl03312 592205000959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592205000960 hemolysin TlyA family protein; Region: tly; TIGR00478 592205000961 RNA binding surface [nucleotide binding]; other site 592205000962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205000963 S-adenosylmethionine binding site [chemical binding]; other site 592205000964 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 592205000965 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592205000966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205000967 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205000968 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592205000969 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 592205000970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205000971 Walker A/P-loop; other site 592205000972 ATP binding site [chemical binding]; other site 592205000973 Q-loop/lid; other site 592205000974 ABC transporter signature motif; other site 592205000975 Walker B; other site 592205000976 D-loop; other site 592205000977 H-loop/switch region; other site 592205000978 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 592205000979 Restriction endonuclease; Region: Mrr_cat; cl00516 592205000980 High-affinity nickel-transport protein; Region: NicO; cl00964 592205000981 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 592205000982 active site 592205000983 Zn binding site [ion binding]; other site 592205000984 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592205000985 metal-binding site [ion binding] 592205000986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592205000987 metal-binding site [ion binding] 592205000988 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 592205000989 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592205000990 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 592205000991 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 592205000992 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 592205000993 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 592205000994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205000995 Walker A motif; other site 592205000996 ATP binding site [chemical binding]; other site 592205000997 Walker B motif; other site 592205000998 arginine finger; other site 592205000999 Peptidase family M41; Region: Peptidase_M41; pfam01434 592205001000 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 592205001001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205001002 S-adenosylmethionine binding site [chemical binding]; other site 592205001003 Response regulator receiver domain; Region: Response_reg; pfam00072 592205001004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205001005 active site 592205001006 phosphorylation site [posttranslational modification] 592205001007 intermolecular recognition site; other site 592205001008 dimerization interface [polypeptide binding]; other site 592205001009 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 592205001011 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 592205001012 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 592205001013 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 592205001014 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 592205001015 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 592205001016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205001017 Walker A motif; other site 592205001018 ATP binding site [chemical binding]; other site 592205001019 Walker B motif; other site 592205001020 arginine finger; other site 592205001021 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 592205001022 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 592205001023 oligomerization interface [polypeptide binding]; other site 592205001024 active site 592205001025 metal binding site [ion binding]; metal-binding site 592205001026 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001027 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001028 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592205001029 septum formation inhibitor; Reviewed; Region: minC; PRK00556 592205001030 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 592205001031 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 592205001032 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 592205001033 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 592205001034 homoserine kinase; Region: thrB; TIGR00191 592205001035 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592205001036 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 592205001037 translation initiation factor IF-2; Validated; Region: infB; PRK05306 592205001038 translation initiation factor IF-2; Region: IF-2; TIGR00487 592205001039 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 592205001040 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 592205001041 G1 box; other site 592205001042 putative GEF interaction site [polypeptide binding]; other site 592205001043 GTP/Mg2+ binding site [chemical binding]; other site 592205001044 Switch I region; other site 592205001045 G2 box; other site 592205001046 G3 box; other site 592205001047 Switch II region; other site 592205001048 G4 box; other site 592205001049 G5 box; other site 592205001050 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 592205001051 Translation-initiation factor 2; Region: IF-2; pfam11987 592205001052 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 592205001053 Ribosome-binding factor A; Region: RBFA; cl00542 592205001054 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 592205001055 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 592205001056 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 592205001057 Sm1 motif; other site 592205001058 D3 - B interaction site; other site 592205001059 D1 - D2 interaction site; other site 592205001060 Hfq - Hfq interaction site; other site 592205001061 RNA binding pocket [nucleotide binding]; other site 592205001062 Sm2 motif; other site 592205001063 acetyl-CoA synthetase; Provisional; Region: PRK00174 592205001064 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 592205001065 AMP-binding enzyme; Region: AMP-binding; cl15778 592205001066 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 592205001067 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592205001068 putative active site [active] 592205001069 putative metal binding site [ion binding]; other site 592205001070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592205001071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592205001072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205001073 active site 592205001074 intermolecular recognition site; other site 592205001075 dimerization interface [polypeptide binding]; other site 592205001076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592205001077 DNA binding site [nucleotide binding] 592205001078 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 592205001079 DHH family; Region: DHH; pfam01368 592205001080 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 592205001081 FHIPEP family; Region: FHIPEP; pfam00771 592205001082 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 592205001083 16S/18S rRNA binding site [nucleotide binding]; other site 592205001084 S13e-L30e interaction site [polypeptide binding]; other site 592205001085 25S rRNA binding site [nucleotide binding]; other site 592205001086 O-Antigen ligase; Region: Wzy_C; cl04850 592205001087 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 592205001088 trimer interface [polypeptide binding]; other site 592205001089 active site 592205001090 dimer interface [polypeptide binding]; other site 592205001091 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592205001092 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 592205001093 active site 592205001094 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 592205001095 catalytic center binding site [active] 592205001096 ATP binding site [chemical binding]; other site 592205001097 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 592205001098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001099 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 592205001100 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 592205001101 P-loop; other site 592205001102 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 592205001103 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 592205001104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592205001105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592205001106 DNA binding residues [nucleotide binding] 592205001107 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 592205001108 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 592205001109 flagellar motor switch protein FliY; Validated; Region: PRK08432 592205001110 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 592205001111 Domain of unknown function (DUF386); Region: DUF386; cl01047 592205001112 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 592205001113 ferric uptake regulator; Provisional; Region: fur; PRK09462 592205001114 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592205001115 metal binding site 2 [ion binding]; metal-binding site 592205001116 putative DNA binding helix; other site 592205001117 metal binding site 1 [ion binding]; metal-binding site 592205001118 dimer interface [polypeptide binding]; other site 592205001119 structural Zn2+ binding site [ion binding]; other site 592205001120 recombination factor protein RarA; Reviewed; Region: PRK13342 592205001121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205001122 Walker A motif; other site 592205001123 ATP binding site [chemical binding]; other site 592205001124 Walker B motif; other site 592205001125 arginine finger; other site 592205001126 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 592205001127 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 592205001128 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592205001129 DNA binding residues [nucleotide binding] 592205001130 putative dimer interface [polypeptide binding]; other site 592205001131 chaperone protein DnaJ; Provisional; Region: PRK14299 592205001132 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592205001133 HSP70 interaction site [polypeptide binding]; other site 592205001134 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 592205001135 substrate binding site [polypeptide binding]; other site 592205001136 dimer interface [polypeptide binding]; other site 592205001137 5'-3' exonuclease; Provisional; Region: PRK14976 592205001138 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 592205001139 putative active site [active] 592205001140 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 592205001141 DNA binding site [nucleotide binding] 592205001142 metal binding site [ion binding]; metal-binding site 592205001143 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592205001144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205001145 active site 592205001146 phosphorylation site [posttranslational modification] 592205001147 intermolecular recognition site; other site 592205001148 dimerization interface [polypeptide binding]; other site 592205001149 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 592205001150 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 592205001151 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 592205001152 substrate binding site; other site 592205001153 dimer interface; other site 592205001154 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 592205001155 homotrimer interaction site [polypeptide binding]; other site 592205001156 zinc binding site [ion binding]; other site 592205001157 CDP-binding sites; other site 592205001158 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 592205001159 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 592205001160 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592205001161 protein binding site [polypeptide binding]; other site 592205001162 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592205001163 protein binding site [polypeptide binding]; other site 592205001164 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 592205001165 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 592205001166 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 592205001167 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 592205001168 putative NAD(P) binding site [chemical binding]; other site 592205001169 active site 592205001170 dihydrodipicolinate synthase; Region: dapA; TIGR00674 592205001171 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 592205001172 dimer interface [polypeptide binding]; other site 592205001173 active site 592205001174 catalytic residue [active] 592205001175 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592205001176 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592205001177 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592205001178 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 592205001179 quinone interaction residues [chemical binding]; other site 592205001180 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 592205001181 active site 592205001182 catalytic residues [active] 592205001183 FMN binding site [chemical binding]; other site 592205001184 substrate binding site [chemical binding]; other site 592205001185 polyphosphate kinase; Provisional; Region: PRK05443 592205001186 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 592205001187 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 592205001188 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 592205001189 putative domain interface [polypeptide binding]; other site 592205001190 putative active site [active] 592205001191 catalytic site [active] 592205001192 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 592205001193 putative active site [active] 592205001194 putative domain interface [polypeptide binding]; other site 592205001195 catalytic site [active] 592205001196 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205001197 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205001198 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 592205001199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 592205001201 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 592205001202 putative metal binding site [ion binding]; other site 592205001203 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 592205001204 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 592205001205 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 592205001206 active site 592205001207 Zn binding site [ion binding]; other site 592205001208 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 592205001209 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 592205001210 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001211 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592205001212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592205001213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205001214 dimer interface [polypeptide binding]; other site 592205001215 conserved gate region; other site 592205001216 putative PBP binding loops; other site 592205001217 ABC-ATPase subunit interface; other site 592205001218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001219 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 592205001220 Walker A/P-loop; other site 592205001221 ATP binding site [chemical binding]; other site 592205001222 Q-loop/lid; other site 592205001223 ABC transporter signature motif; other site 592205001224 Walker B; other site 592205001225 D-loop; other site 592205001226 H-loop/switch region; other site 592205001227 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 592205001228 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592205001229 active site 592205001230 HIGH motif; other site 592205001231 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592205001232 active site 592205001233 KMSKS motif; other site 592205001234 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001235 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 592205001236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001237 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 592205001238 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592205001239 ADP-heptose:LPS heptosyltransferase II; Provisional; Region: PRK10916; cl15782 592205001240 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 592205001241 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 592205001242 G1 box; other site 592205001243 putative GEF interaction site [polypeptide binding]; other site 592205001244 GTP/Mg2+ binding site [chemical binding]; other site 592205001245 Switch I region; other site 592205001246 G2 box; other site 592205001247 G3 box; other site 592205001248 Switch II region; other site 592205001249 G4 box; other site 592205001250 G5 box; other site 592205001251 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 592205001252 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 592205001253 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 592205001254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 592205001255 cofactor binding site; other site 592205001256 DNA binding site [nucleotide binding] 592205001257 substrate interaction site [chemical binding]; other site 592205001258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 592205001259 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 592205001260 putative heme binding pocket [chemical binding]; other site 592205001261 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205001262 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205001263 Uncharacterized conserved protein [Function unknown]; Region: COG1432 592205001264 LabA_like proteins; Region: LabA_like; cd06167 592205001265 putative metal binding site [ion binding]; other site 592205001266 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 592205001267 active site 592205001268 putative DNA-binding cleft [nucleotide binding]; other site 592205001269 dimer interface [polypeptide binding]; other site 592205001270 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 592205001271 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 592205001272 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 592205001273 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 592205001274 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 592205001275 tetramer interface [polypeptide binding]; other site 592205001276 heme binding pocket [chemical binding]; other site 592205001277 NADPH binding site [chemical binding]; other site 592205001278 alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686 592205001279 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 592205001280 PhnA protein; Region: PhnA; pfam03831 592205001281 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 592205001282 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 592205001283 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 592205001284 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 592205001285 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 592205001286 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205001287 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 592205001288 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 592205001289 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 592205001290 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 592205001291 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 592205001292 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 592205001293 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592205001294 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 592205001295 trimer interface [polypeptide binding]; other site 592205001296 active site 592205001297 PQQ-like domain; Region: PQQ_2; pfam13360 592205001298 Type III pantothenate kinase; Region: Pan_kinase; cl09130 592205001299 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 592205001300 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 592205001301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592205001302 active site 592205001303 motif I; other site 592205001304 motif II; other site 592205001305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001306 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 592205001307 NAD(P) binding site [chemical binding]; other site 592205001308 active site 592205001309 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 592205001310 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 592205001311 putative ribose interaction site [chemical binding]; other site 592205001312 putative ADP binding site [chemical binding]; other site 592205001313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592205001314 active site 592205001315 nucleotide binding site [chemical binding]; other site 592205001316 HIGH motif; other site 592205001317 KMSKS motif; other site 592205001318 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 592205001319 dimer interface [polypeptide binding]; other site 592205001320 active site 592205001321 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 592205001322 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 592205001323 active site 592205001324 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 592205001325 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 592205001326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001327 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 592205001328 ABC transporter; Region: ABC_tran_2; pfam12848 592205001329 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 592205001330 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592205001331 active site 592205001332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205001333 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 592205001334 substrate binding site [chemical binding]; other site 592205001335 multimerization interface [polypeptide binding]; other site 592205001336 ATP binding site [chemical binding]; other site 592205001337 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 592205001338 dimer interface [polypeptide binding]; other site 592205001339 substrate binding site [chemical binding]; other site 592205001340 ATP binding site [chemical binding]; other site 592205001341 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 592205001342 thiamine phosphate binding site [chemical binding]; other site 592205001343 active site 592205001344 pyrophosphate binding site [ion binding]; other site 592205001345 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 592205001346 Flavoprotein; Region: Flavoprotein; cl08021 592205001347 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 592205001348 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 592205001349 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 592205001350 NAD(P) binding site [chemical binding]; other site 592205001351 homodimer interface [polypeptide binding]; other site 592205001352 substrate binding site [chemical binding]; other site 592205001353 active site 592205001354 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 592205001355 LPP20 lipoprotein; Region: LPP20; cl15824 592205001356 LPP20 lipoprotein; Region: LPP20; cl15824 592205001357 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592205001358 IHF dimer interface [polypeptide binding]; other site 592205001359 IHF - DNA interface [nucleotide binding]; other site 592205001360 GTP-binding protein Der; Reviewed; Region: PRK00093 592205001361 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 592205001362 G1 box; other site 592205001363 GTP/Mg2+ binding site [chemical binding]; other site 592205001364 Switch I region; other site 592205001365 G2 box; other site 592205001366 Switch II region; other site 592205001367 G3 box; other site 592205001368 G4 box; other site 592205001369 G5 box; other site 592205001370 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 592205001371 G1 box; other site 592205001372 GTP/Mg2+ binding site [chemical binding]; other site 592205001373 Switch I region; other site 592205001374 G2 box; other site 592205001375 G3 box; other site 592205001376 Switch II region; other site 592205001377 G4 box; other site 592205001378 G5 box; other site 592205001379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 592205001380 spermidine synthase; Provisional; Region: PRK00811 592205001381 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 592205001382 CoA-binding site [chemical binding]; other site 592205001383 Amidase; Region: Amidase; cl11426 592205001384 indole acetimide hydrolase; Validated; Region: PRK07488 592205001385 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 592205001386 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 592205001387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 592205001388 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 592205001389 active site 592205001390 ATP synthase A chain; Region: ATP-synt_A; cl00413 592205001391 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 592205001392 RNA/DNA binding site [nucleotide binding]; other site 592205001393 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 592205001394 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 592205001395 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 592205001396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592205001398 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592205001399 catalytic residues [active] 592205001400 Restriction endonuclease; Region: Mrr_cat; cl00516 592205001401 homoserine dehydrogenase; Provisional; Region: PRK06349 592205001402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001403 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 592205001404 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 592205001405 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 592205001406 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592205001407 GIY-YIG motif/motif A; other site 592205001408 active site 592205001409 catalytic site [active] 592205001410 putative DNA binding site [nucleotide binding]; other site 592205001411 metal binding site [ion binding]; metal-binding site 592205001412 UvrB/uvrC motif; Region: UVR; pfam02151 592205001413 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 592205001414 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592205001415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001416 Walker A/P-loop; other site 592205001417 ATP binding site [chemical binding]; other site 592205001418 Q-loop/lid; other site 592205001419 ABC transporter signature motif; other site 592205001420 Walker B; other site 592205001421 D-loop; other site 592205001422 H-loop/switch region; other site 592205001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205001424 dimer interface [polypeptide binding]; other site 592205001425 conserved gate region; other site 592205001426 ABC-ATPase subunit interface; other site 592205001427 NMT1-like family; Region: NMT1_2; cl15260 592205001428 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592205001429 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 592205001430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592205001431 ligand binding site [chemical binding]; other site 592205001432 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 592205001433 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592205001434 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 592205001435 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 592205001436 ATP binding site [chemical binding]; other site 592205001437 substrate interface [chemical binding]; other site 592205001438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 592205001439 Uncharacterized conserved protein [Function unknown]; Region: COG1565 592205001440 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 592205001441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001442 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 592205001443 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 592205001444 Protein of unknown function DUF45; Region: DUF45; cl00636 592205001445 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 592205001446 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 592205001447 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 592205001448 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 592205001449 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 592205001450 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 592205001451 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 592205001452 dimerization interface [polypeptide binding]; other site 592205001453 active site 592205001454 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 592205001455 MoaE interaction surface [polypeptide binding]; other site 592205001456 MoeB interaction surface [polypeptide binding]; other site 592205001457 thiocarboxylated glycine; other site 592205001458 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 592205001459 MoaE homodimer interface [polypeptide binding]; other site 592205001460 MoaD interaction [polypeptide binding]; other site 592205001461 active site residues [active] 592205001462 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 592205001463 MPT binding site; other site 592205001464 trimer interface [polypeptide binding]; other site 592205001465 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 592205001466 trimer interface [polypeptide binding]; other site 592205001467 dimer interface [polypeptide binding]; other site 592205001468 putative active site [active] 592205001469 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 592205001470 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001471 trigger factor; Provisional; Region: tig; PRK01490 592205001472 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 592205001473 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 592205001474 Clp protease; Region: CLP_protease; pfam00574 592205001475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592205001476 oligomer interface [polypeptide binding]; other site 592205001477 active site residues [active] 592205001478 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 592205001479 active site 592205001480 catalytic residues [active] 592205001481 metal binding site [ion binding]; metal-binding site 592205001482 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 592205001483 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 592205001484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001485 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 592205001486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592205001487 metal-binding site [ion binding] 592205001488 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 592205001489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592205001490 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 592205001491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 592205001492 Probable transposase; Region: OrfB_IS605; pfam01385 592205001493 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 592205001494 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 592205001495 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 592205001496 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592205001497 DNA binding residues [nucleotide binding] 592205001498 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 592205001499 catalytic residues [active] 592205001500 catalytic nucleophile [active] 592205001501 YcfA-like protein; Region: YcfA; cl00752 592205001502 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 592205001503 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205001504 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 592205001505 FtsX-like permease family; Region: FtsX; cl15850 592205001506 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 592205001507 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 592205001508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592205001509 nucleotide binding region [chemical binding]; other site 592205001510 ATP-binding site [chemical binding]; other site 592205001511 SEC-C motif; Region: SEC-C; pfam02810 592205001512 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 592205001513 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 592205001514 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205001515 DDE superfamily endonuclease; Region: DDE_5; cl02413 592205001516 aconitate hydratase 2; Region: acnB; TIGR00117 592205001517 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 592205001518 substrate binding site [chemical binding]; other site 592205001519 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 592205001520 substrate binding site [chemical binding]; other site 592205001521 ligand binding site [chemical binding]; other site 592205001522 NMT1-like family; Region: NMT1_2; cl15260 592205001523 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 592205001524 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 592205001525 putative nucleotide binding site [chemical binding]; other site 592205001526 uridine monophosphate binding site [chemical binding]; other site 592205001527 homohexameric interface [polypeptide binding]; other site 592205001528 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 592205001529 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 592205001530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 592205001531 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592205001532 synthetase active site [active] 592205001533 NTP binding site [chemical binding]; other site 592205001534 metal binding site [ion binding]; metal-binding site 592205001535 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 592205001536 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 592205001537 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 592205001538 active site 592205001539 HIGH motif; other site 592205001540 dimer interface [polypeptide binding]; other site 592205001541 KMSKS motif; other site 592205001542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592205001543 RNA binding surface [nucleotide binding]; other site 592205001544 Nitronate monooxygenase; Region: NMO; pfam03060 592205001545 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 592205001546 FMN binding site [chemical binding]; other site 592205001547 substrate binding site [chemical binding]; other site 592205001548 putative catalytic residue [active] 592205001549 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592205001550 active site 592205001551 metal binding site [ion binding]; metal-binding site 592205001552 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 592205001553 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 592205001554 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 592205001555 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 592205001556 GTP binding site; other site 592205001557 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 592205001558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205001559 FeS/SAM binding site; other site 592205001560 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 592205001561 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 592205001562 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592205001563 P loop; other site 592205001564 GTP binding site [chemical binding]; other site 592205001565 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 592205001566 phosphodiesterase; Provisional; Region: PRK12704 592205001567 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 592205001568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592205001569 Zn2+ binding site [ion binding]; other site 592205001570 Mg2+ binding site [ion binding]; other site 592205001571 putative efflux protein, MATE family; Region: matE; TIGR00797 592205001572 MatE; Region: MatE; cl10513 592205001573 MatE; Region: MatE; cl10513 592205001574 Predicted permease [General function prediction only]; Region: COG2056 592205001575 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 592205001576 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 592205001577 N-carbamolyputrescine amidase; Region: PLN02747 592205001578 putative active site; other site 592205001579 catalytic triad [active] 592205001580 putative dimer interface [polypeptide binding]; other site 592205001581 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 592205001582 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 592205001583 putative ATP binding site [chemical binding]; other site 592205001584 putative substrate interface [chemical binding]; other site 592205001585 Flagellar protein FliS; Region: FliS; cl00654 592205001586 flagellar capping protein; Validated; Region: fliD; PRK08453 592205001587 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 592205001588 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 592205001589 FlaG protein; Region: FlaG; cl00591 592205001590 Peptidase family M23; Region: Peptidase_M23; pfam01551 592205001591 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 592205001592 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592205001593 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 592205001594 Walker A/P-loop; other site 592205001595 ATP binding site [chemical binding]; other site 592205001596 Q-loop/lid; other site 592205001597 ABC transporter signature motif; other site 592205001598 Walker B; other site 592205001599 D-loop; other site 592205001600 H-loop/switch region; other site 592205001601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205001602 S-adenosylmethionine binding site [chemical binding]; other site 592205001603 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 592205001604 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 592205001605 Interdomain contacts; other site 592205001606 Cytokine receptor motif; other site 592205001607 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 592205001608 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592205001609 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 592205001610 active site 592205001611 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 592205001612 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 592205001613 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 592205001614 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592205001615 active site 592205001616 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 592205001617 nucleotide binding site/active site [active] 592205001618 HIT family signature motif; other site 592205001619 catalytic residue [active] 592205001620 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 592205001621 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592205001622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592205001623 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 592205001624 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 592205001625 ATP-grasp domain; Region: ATP-grasp_4; cl03087 592205001626 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 592205001627 tetramer interfaces [polypeptide binding]; other site 592205001628 binuclear metal-binding site [ion binding]; other site 592205001629 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 592205001630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592205001631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592205001632 catalytic residue [active] 592205001633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592205001634 active site 592205001635 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 592205001636 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592205001637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205001638 FeS/SAM binding site; other site 592205001639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001640 G1 box; other site 592205001641 GTP/Mg2+ binding site [chemical binding]; other site 592205001642 Switch I region; other site 592205001643 G3 box; other site 592205001644 Switch II region; other site 592205001645 G4 box; other site 592205001646 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 592205001647 Ligand Binding Site [chemical binding]; other site 592205001648 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 592205001649 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592205001650 FMN binding site [chemical binding]; other site 592205001651 active site 592205001652 catalytic residues [active] 592205001653 substrate binding site [chemical binding]; other site 592205001654 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001655 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 592205001656 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 592205001657 active site 592205001658 homodimer interface [polypeptide binding]; other site 592205001659 homotetramer interface [polypeptide binding]; other site 592205001660 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 592205001661 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 592205001662 LysE type translocator; Region: LysE; cl00565 592205001663 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 592205001664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205001665 Walker A motif; other site 592205001666 ATP binding site [chemical binding]; other site 592205001667 Walker B motif; other site 592205001668 arginine finger; other site 592205001669 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 592205001670 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 592205001671 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 592205001672 Walker A/P-loop; other site 592205001673 ATP binding site [chemical binding]; other site 592205001674 Q-loop/lid; other site 592205001675 ABC transporter signature motif; other site 592205001676 Walker B; other site 592205001677 D-loop; other site 592205001678 H-loop/switch region; other site 592205001679 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 592205001680 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 592205001681 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 592205001682 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 592205001683 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 592205001684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 592205001685 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001686 Uncharacterized conserved protein [Function unknown]; Region: COG1912 592205001687 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 592205001688 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 592205001689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001690 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001691 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 592205001692 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 592205001693 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 592205001694 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 592205001695 Response regulator receiver domain; Region: Response_reg; pfam00072 592205001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205001697 active site 592205001698 phosphorylation site [posttranslational modification] 592205001699 intermolecular recognition site; other site 592205001700 dimerization interface [polypeptide binding]; other site 592205001701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205001702 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592205001703 Walker A motif; other site 592205001704 ATP binding site [chemical binding]; other site 592205001705 Walker B motif; other site 592205001706 arginine finger; other site 592205001707 DNA gyrase subunit A; Validated; Region: PRK05560 592205001708 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 592205001709 CAP-like domain; other site 592205001710 active site 592205001711 primary dimer interface [polypeptide binding]; other site 592205001712 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001713 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001714 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001715 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001716 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001717 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592205001718 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 592205001719 Protein of unknown function DUF262; Region: DUF262; cl14890 592205001720 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 592205001721 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 592205001722 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 592205001723 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 592205001724 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 592205001725 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 592205001726 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 592205001727 putative acyltransferase; Provisional; Region: PRK05790 592205001728 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592205001729 dimer interface [polypeptide binding]; other site 592205001730 active site 592205001731 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 592205001732 active site 592205001733 catalytic site [active] 592205001734 substrate binding site [chemical binding]; other site 592205001735 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 592205001736 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 592205001737 ferrous iron transporter FeoB; Region: feoB; TIGR00437 592205001738 G1 box; other site 592205001739 GTP/Mg2+ binding site [chemical binding]; other site 592205001740 Switch I region; other site 592205001741 G2 box; other site 592205001742 G3 box; other site 592205001743 Switch II region; other site 592205001744 G4 box; other site 592205001745 G5 box; other site 592205001746 Nucleoside recognition; Region: Gate; cl00486 592205001747 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 592205001748 Nucleoside recognition; Region: Gate; cl00486 592205001749 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 592205001750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592205001751 N-terminal plug; other site 592205001752 ligand-binding site [chemical binding]; other site 592205001753 FliP family; Region: FliP; cl00593 592205001754 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 592205001755 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 592205001756 Substrate binding site; other site 592205001757 Mg++ binding site; other site 592205001758 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 592205001759 active site 592205001760 substrate binding site [chemical binding]; other site 592205001761 CoA binding site [chemical binding]; other site 592205001762 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 592205001763 ATP cone domain; Region: ATP-cone; pfam03477 592205001764 Class I ribonucleotide reductase; Region: RNR_I; cd01679 592205001765 active site 592205001766 dimer interface [polypeptide binding]; other site 592205001767 catalytic residues [active] 592205001768 effector binding site; other site 592205001769 R2 peptide binding site; other site 592205001770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001771 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 592205001772 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 592205001773 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 592205001774 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 592205001775 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592205001776 DNA binding site [nucleotide binding] 592205001777 active site 592205001778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592205001779 DNA binding site [nucleotide binding] 592205001780 Int/Topo IB signature motif; other site 592205001781 active site 592205001782 aspartate aminotransferase; Provisional; Region: PRK05764 592205001783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592205001784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205001785 homodimer interface [polypeptide binding]; other site 592205001786 catalytic residue [active] 592205001787 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 592205001789 Probable transposase; Region: OrfB_IS605; pfam01385 592205001790 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 592205001791 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 592205001792 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 592205001793 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592205001794 DNA binding residues [nucleotide binding] 592205001795 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 592205001796 catalytic residues [active] 592205001797 catalytic nucleophile [active] 592205001798 YcfA-like protein; Region: YcfA; cl00752 592205001799 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 592205001800 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592205001801 Cysteine-rich domain; Region: CCG; pfam02754 592205001802 Cysteine-rich domain; Region: CCG; pfam02754 592205001803 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 592205001804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205001805 FeS/SAM binding site; other site 592205001806 HemN C-terminal domain; Region: HemN_C; pfam06969 592205001807 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 592205001808 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 592205001809 Tetramer interface [polypeptide binding]; other site 592205001810 active site 592205001811 FMN-binding site [chemical binding]; other site 592205001812 ribonuclease III; Reviewed; Region: rnc; PRK00102 592205001813 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 592205001814 dimerization interface [polypeptide binding]; other site 592205001815 active site 592205001816 metal binding site [ion binding]; metal-binding site 592205001817 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 592205001818 dsRNA binding site [nucleotide binding]; other site 592205001819 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 592205001820 RNA/DNA hybrid binding site [nucleotide binding]; other site 592205001821 active site 592205001822 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 592205001823 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 592205001824 SurA N-terminal domain; Region: SurA_N_3; cl07813 592205001825 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 592205001826 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 592205001827 GatB domain; Region: GatB_Yqey; cl11497 592205001828 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592205001829 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592205001830 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592205001831 hypothetical protein; Provisional; Region: PRK08445 592205001832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205001833 FeS/SAM binding site; other site 592205001834 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 592205001835 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 592205001836 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 592205001837 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 592205001838 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 592205001839 Surface antigen; Region: Bac_surface_Ag; cl03097 592205001840 hypothetical protein; Provisional; Region: PRK08444 592205001841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205001842 FeS/SAM binding site; other site 592205001843 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 592205001844 Ferritin-like domain; Region: Ferritin; pfam00210 592205001845 ferroxidase diiron center [ion binding]; other site 592205001846 phosphoserine phosphatase SerB; Region: serB; TIGR00338 592205001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592205001848 motif II; other site 592205001849 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 592205001850 Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851 592205001851 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_2; cd10034 592205001852 putative uracil binding site [chemical binding]; other site 592205001853 putative active site [active] 592205001854 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 592205001855 Aspartase; Region: Aspartase; cd01357 592205001856 active sites [active] 592205001857 tetramer interface [polypeptide binding]; other site 592205001858 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 592205001859 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 592205001860 hinge; other site 592205001861 active site 592205001862 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592205001863 active site 592205001864 tetramer interface; other site 592205001865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 592205001866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592205001867 catalytic residue [active] 592205001868 YGGT family; Region: YGGT; cl00508 592205001869 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 592205001870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592205001871 active site 592205001872 HIGH motif; other site 592205001873 nucleotide binding site [chemical binding]; other site 592205001874 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592205001875 active site 592205001876 KMSKS motif; other site 592205001877 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592205001878 dimer interface [polypeptide binding]; other site 592205001879 FMN binding site [chemical binding]; other site 592205001880 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592205001881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205001882 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 592205001883 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 592205001884 active site 592205001885 NTP binding site [chemical binding]; other site 592205001886 metal binding triad [ion binding]; metal-binding site 592205001887 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 592205001888 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 592205001889 Ligand Binding Site [chemical binding]; other site 592205001890 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001891 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 592205001892 nickel binding site [ion binding]; other site 592205001893 putative substrate-binding site; other site 592205001894 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 592205001895 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 592205001896 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 592205001897 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 592205001898 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 592205001899 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 592205001900 Sel1 repeat; Region: Sel1; cl02723 592205001901 Sel1 repeat; Region: Sel1; cl02723 592205001902 Sel1 repeat; Region: Sel1; cl02723 592205001903 Sel1 repeat; Region: Sel1; cl02723 592205001904 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 592205001905 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 592205001906 putative trimer interface [polypeptide binding]; other site 592205001907 putative CoA binding site [chemical binding]; other site 592205001908 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 592205001909 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592205001910 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592205001911 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 592205001912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592205001913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205001914 homodimer interface [polypeptide binding]; other site 592205001915 catalytic residue [active] 592205001916 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 592205001917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592205001918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592205001919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592205001920 MutS2 family protein; Region: mutS2; TIGR01069 592205001921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001922 Walker A/P-loop; other site 592205001923 ATP binding site [chemical binding]; other site 592205001924 Q-loop/lid; other site 592205001925 ABC transporter signature motif; other site 592205001926 Walker B; other site 592205001927 D-loop; other site 592205001928 H-loop/switch region; other site 592205001929 Smr domain; Region: Smr; cl02619 592205001930 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 592205001931 dimer interface [polypeptide binding]; other site 592205001932 substrate binding site [chemical binding]; other site 592205001933 metal binding sites [ion binding]; metal-binding site 592205001934 adenylate kinase; Reviewed; Region: adk; PRK00279 592205001935 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 592205001936 AMP-binding site [chemical binding]; other site 592205001937 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 592205001938 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 592205001939 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 592205001940 dimer interface [polypeptide binding]; other site 592205001941 anticodon binding site; other site 592205001942 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 592205001943 homodimer interface [polypeptide binding]; other site 592205001944 motif 1; other site 592205001945 active site 592205001946 motif 2; other site 592205001947 GAD domain; Region: GAD; pfam02938 592205001948 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 592205001949 active site 592205001950 motif 3; other site 592205001951 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 592205001952 Response regulator receiver domain; Region: Response_reg; pfam00072 592205001953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205001954 active site 592205001955 phosphorylation site [posttranslational modification] 592205001956 intermolecular recognition site; other site 592205001957 dimerization interface [polypeptide binding]; other site 592205001958 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 592205001959 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 592205001960 nucleotide binding pocket [chemical binding]; other site 592205001961 K-X-D-G motif; other site 592205001962 catalytic site [active] 592205001963 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 592205001964 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 592205001965 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 592205001966 Dimer interface [polypeptide binding]; other site 592205001967 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205001968 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205001969 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205001970 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205001971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 592205001972 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205001973 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 592205001974 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205001975 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 592205001976 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205001977 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205001978 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592205001979 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 592205001980 substrate binding site [chemical binding]; other site 592205001981 active site 592205001982 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 592205001983 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592205001984 minor groove reading motif; other site 592205001985 helix-hairpin-helix signature motif; other site 592205001986 active site 592205001987 flagellin A; Reviewed; Region: PRK12584 592205001988 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592205001989 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 592205001990 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 592205001991 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592205001992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592205001993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205001994 Walker A/P-loop; other site 592205001995 ATP binding site [chemical binding]; other site 592205001996 Q-loop/lid; other site 592205001997 ABC transporter signature motif; other site 592205001998 Walker B; other site 592205001999 D-loop; other site 592205002000 H-loop/switch region; other site 592205002001 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592205002002 dimer interface [polypeptide binding]; other site 592205002003 putative CheW interface [polypeptide binding]; other site 592205002004 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 592205002005 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 592205002006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592205002007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592205002008 catalytic residue [active] 592205002009 Transglycosylase; Region: Transgly; cl07896 592205002010 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 592205002011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 592205002012 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 592205002013 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 592205002014 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 592205002015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002017 Restriction endonuclease [Defense mechanisms]; Region: COG3587 592205002018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002019 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 592205002020 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 592205002021 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 592205002022 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 592205002023 TPP-binding site [chemical binding]; other site 592205002024 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 592205002025 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 592205002026 dimer interface [polypeptide binding]; other site 592205002027 PYR/PP interface [polypeptide binding]; other site 592205002028 TPP binding site [chemical binding]; other site 592205002029 substrate binding site [chemical binding]; other site 592205002030 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 592205002031 4Fe-4S binding domain; Region: Fer4; cl02805 592205002032 YceG-like family; Region: YceG; pfam02618 592205002033 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 592205002034 dimerization interface [polypeptide binding]; other site 592205002035 Protein of unknown function; Region: DUF3971; pfam13116 592205002036 AsmA-like C-terminal region; Region: AsmA_2; cl15864 592205002037 FeoA domain; Region: FeoA; cl00838 592205002038 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 592205002039 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592205002040 minor groove reading motif; other site 592205002041 helix-hairpin-helix signature motif; other site 592205002042 substrate binding pocket [chemical binding]; other site 592205002043 active site 592205002044 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 592205002045 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 592205002046 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 592205002047 Gram-negative bacterial tonB protein; Region: TonB; cl10048 592205002048 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 592205002049 active site 592205002050 substrate binding pocket [chemical binding]; other site 592205002051 dimer interface [polypeptide binding]; other site 592205002052 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 592205002053 BNR repeat-like domain; Region: BNR_2; pfam13088 592205002054 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 592205002055 Sulfatase; Region: Sulfatase; cl10460 592205002056 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 592205002057 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 592205002058 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 592205002059 homodimer interface [polypeptide binding]; other site 592205002060 NADP binding site [chemical binding]; other site 592205002061 substrate binding site [chemical binding]; other site 592205002062 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592205002063 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592205002064 Catalytic site [active] 592205002065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592205002066 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 592205002067 active site 592205002068 putative substrate binding region [chemical binding]; other site 592205002069 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 592205002070 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592205002071 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 592205002072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592205002073 active site 592205002074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592205002075 multifunctional aminopeptidase A; Provisional; Region: PRK00913 592205002076 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 592205002077 interface (dimer of trimers) [polypeptide binding]; other site 592205002078 Substrate-binding/catalytic site; other site 592205002079 Zn-binding sites [ion binding]; other site 592205002080 GTP-binding protein YchF; Reviewed; Region: PRK09601 592205002081 YchF GTPase; Region: YchF; cd01900 592205002082 G1 box; other site 592205002083 GTP/Mg2+ binding site [chemical binding]; other site 592205002084 Switch I region; other site 592205002085 G2 box; other site 592205002086 Switch II region; other site 592205002087 G3 box; other site 592205002088 G4 box; other site 592205002089 G5 box; other site 592205002090 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 592205002091 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 592205002092 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592205002093 diaminopimelate epimerase; Region: DapF; TIGR00652 592205002094 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 592205002095 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 592205002096 Protein of unknown function, DUF417; Region: DUF417; cl01162 592205002097 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 592205002098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592205002099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002100 NAD(P) binding site [chemical binding]; other site 592205002101 active site 592205002102 Phosphopantetheine attachment site; Region: PP-binding; cl09936 592205002103 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 592205002104 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592205002105 dimer interface [polypeptide binding]; other site 592205002106 active site 592205002107 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 592205002108 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 592205002109 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 592205002110 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 592205002111 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 592205002112 probable S-adenosylmethionine-dependent methyltransferase, YraL family; Region: TIGR00096 592205002113 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 592205002114 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 592205002115 transcription termination factor Rho; Provisional; Region: rho; PRK09376 592205002116 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 592205002117 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 592205002118 RNA binding site [nucleotide binding]; other site 592205002119 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 592205002120 multimer interface [polypeptide binding]; other site 592205002121 Walker A motif; other site 592205002122 ATP binding site [chemical binding]; other site 592205002123 Walker B motif; other site 592205002124 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 592205002125 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 592205002126 Sel1 repeat; Region: Sel1; cl02723 592205002127 Sel1 repeat; Region: Sel1; cl02723 592205002128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 592205002129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 592205002130 GTPase Era; Reviewed; Region: era; PRK00089 592205002131 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 592205002132 G1 box; other site 592205002133 GTP/Mg2+ binding site [chemical binding]; other site 592205002134 Switch I region; other site 592205002135 G2 box; other site 592205002136 Switch II region; other site 592205002137 G3 box; other site 592205002138 G4 box; other site 592205002139 G5 box; other site 592205002140 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 592205002141 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 592205002142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002144 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 592205002145 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 592205002146 active site 592205002147 HslU subunit interaction site [polypeptide binding]; other site 592205002148 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 592205002149 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 592205002150 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 592205002151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 592205002152 Probable transposase; Region: OrfB_IS605; pfam01385 592205002153 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 592205002154 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 592205002155 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 592205002156 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592205002157 DNA binding residues [nucleotide binding] 592205002158 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 592205002159 catalytic residues [active] 592205002160 catalytic nucleophile [active] 592205002161 YcfA-like protein; Region: YcfA; cl00752 592205002162 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 592205002163 glutamine synthetase, type I; Region: GlnA; TIGR00653 592205002164 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 592205002165 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592205002166 dihydrodipicolinate reductase; Region: dapB; TIGR00036 592205002167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002168 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 592205002169 FAD binding domain; Region: FAD_binding_4; pfam01565 592205002170 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 592205002171 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 592205002172 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 592205002173 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592205002174 dimer interface [polypeptide binding]; other site 592205002175 ADP-ribose binding site [chemical binding]; other site 592205002176 active site 592205002177 nudix motif; other site 592205002178 metal binding site [ion binding]; metal-binding site 592205002179 Peptidase family M23; Region: Peptidase_M23; pfam01551 592205002180 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 592205002181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 592205002182 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592205002183 anchoring element; other site 592205002184 dimer interface [polypeptide binding]; other site 592205002185 ATP binding site [chemical binding]; other site 592205002186 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 592205002187 active site 592205002188 putative metal-binding site [ion binding]; other site 592205002189 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592205002190 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 592205002191 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 592205002192 putative DNA binding surface [nucleotide binding]; other site 592205002193 dimer interface [polypeptide binding]; other site 592205002194 beta-clamp/translesion DNA polymerase binding surface; other site 592205002195 beta-clamp/clamp loader binding surface; other site 592205002196 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 592205002197 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 592205002198 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592205002199 active site 592205002200 Protein of unknown function (DUF493); Region: DUF493; cl01102 592205002201 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 592205002202 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592205002203 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592205002204 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 592205002205 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 592205002206 Mg++ binding site [ion binding]; other site 592205002207 putative catalytic motif [active] 592205002208 putative substrate binding site [chemical binding]; other site 592205002209 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 592205002210 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 592205002211 Cation transport protein; Region: TrkH; cl10514 592205002212 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 592205002213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002214 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 592205002215 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 592205002216 RuvA N terminal domain; Region: RuvA_N; pfam01330 592205002217 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 592205002218 MviN-like protein; Region: MVIN; pfam03023 592205002219 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 592205002220 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592205002221 active site 592205002222 HIGH motif; other site 592205002223 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592205002224 KMSKS motif; other site 592205002225 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 592205002226 tRNA binding surface [nucleotide binding]; other site 592205002227 anticodon binding site; other site 592205002228 Vacuolating cyotoxin; Region: VacA; pfam02691 592205002229 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 592205002230 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592205002231 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592205002232 Walker A/P-loop; other site 592205002233 ATP binding site [chemical binding]; other site 592205002234 Q-loop/lid; other site 592205002235 ABC transporter signature motif; other site 592205002236 Walker B; other site 592205002237 D-loop; other site 592205002238 H-loop/switch region; other site 592205002239 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 592205002240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592205002241 ABC-ATPase subunit interface; other site 592205002242 dimer interface [polypeptide binding]; other site 592205002243 putative PBP binding regions; other site 592205002244 short chain dehydrogenase; Validated; Region: PRK06182 592205002245 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592205002246 NADP binding site [chemical binding]; other site 592205002247 active site 592205002248 steroid binding site; other site 592205002249 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592205002250 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 592205002251 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002252 potential protein location (Conserved hypothetical protein [Helicobacter pylori B38]) that overlaps RNA (tRNA-Q) 592205002253 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 592205002254 Hydrogenase formation hypA family; Region: HypD; cl12072 592205002255 HupF/HypC family; Region: HupF_HypC; cl00394 592205002256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002257 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592205002258 Cupin domain; Region: Cupin_2; cl09118 592205002259 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 592205002260 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 592205002261 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 592205002262 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 592205002263 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 592205002264 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 592205002265 FlgD Ig-like domain; Region: FlgD_ig; cl15790 592205002266 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 592205002267 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205002268 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 592205002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002270 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 592205002271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002272 Family description; Region: UvrD_C_2; cl15862 592205002273 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002274 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002275 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205002276 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 592205002277 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 592205002278 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 592205002279 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 592205002280 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592205002281 ATP-grasp domain; Region: ATP-grasp_4; cl03087 592205002282 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 592205002283 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592205002284 ATP-grasp domain; Region: ATP-grasp_4; cl03087 592205002285 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 592205002286 IMP binding site; other site 592205002287 dimer interface [polypeptide binding]; other site 592205002288 interdomain contacts; other site 592205002289 partial ornithine binding site; other site 592205002290 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 592205002291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002292 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 592205002293 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 592205002294 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205002295 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205002296 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 592205002297 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 592205002298 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 592205002299 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002300 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 592205002301 active site 1 [active] 592205002302 dimer interface [polypeptide binding]; other site 592205002303 hexamer interface [polypeptide binding]; other site 592205002304 active site 2 [active] 592205002305 recombination protein RecR; Region: recR; TIGR00615 592205002306 RecR protein; Region: RecR; pfam02132 592205002307 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 592205002308 putative active site [active] 592205002309 putative metal-binding site [ion binding]; other site 592205002310 tetramer interface [polypeptide binding]; other site 592205002311 tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094 592205002312 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 592205002313 Permutation of conserved domain; other site 592205002314 active site 592205002315 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 592205002316 Peptidase family M48; Region: Peptidase_M48; cl12018 592205002317 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592205002318 GTP cyclohydrolase I; Provisional; Region: PLN03044 592205002319 active site 592205002320 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592205002321 substrate binding pocket [chemical binding]; other site 592205002322 chain length determination region; other site 592205002323 substrate-Mg2+ binding site; other site 592205002324 catalytic residues [active] 592205002325 aspartate-rich region 1; other site 592205002326 active site lid residues [active] 592205002327 aspartate-rich region 2; other site 592205002328 Survival protein SurE; Region: SurE; cl00448 592205002329 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592205002330 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 592205002331 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592205002332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592205002333 Coenzyme A binding pocket [chemical binding]; other site 592205002334 Protein of unknown function DUF262; Region: DUF262; cl14890 592205002335 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592205002336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205002337 dimer interface [polypeptide binding]; other site 592205002338 conserved gate region; other site 592205002339 putative PBP binding loops; other site 592205002340 ABC-ATPase subunit interface; other site 592205002341 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592205002342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592205002343 substrate binding pocket [chemical binding]; other site 592205002344 membrane-bound complex binding site; other site 592205002345 hinge residues; other site 592205002346 alanine racemase; Region: alr; TIGR00492 592205002347 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 592205002348 active site 592205002349 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592205002350 dimer interface [polypeptide binding]; other site 592205002351 substrate binding site [chemical binding]; other site 592205002352 catalytic residues [active] 592205002353 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 592205002354 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 592205002355 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592205002356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002357 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592205002358 homotrimer interaction site [polypeptide binding]; other site 592205002359 putative active site [active] 592205002360 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 592205002361 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 592205002362 TIGR01210 family protein; Region: TIGR01210 592205002363 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 592205002364 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 592205002365 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 592205002366 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 592205002367 Recombination protein O N terminal; Region: RecO_N; cl15812 592205002368 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 592205002369 Competence-damaged protein; Region: CinA; cl00666 592205002370 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592205002371 dimer interface [polypeptide binding]; other site 592205002372 FMN binding site [chemical binding]; other site 592205002373 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 592205002374 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 592205002375 active site 592205002376 pseudouridine synthase; Region: TIGR00093 592205002377 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 592205002378 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 592205002379 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592205002380 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 592205002381 Putative zinc ribbon domain; Region: DUF164; pfam02591 592205002382 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 592205002383 Uncharacterized conserved protein [Function unknown]; Region: COG0327 592205002384 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 592205002385 dimer interface [polypeptide binding]; other site 592205002386 motif 1; other site 592205002387 active site 592205002388 motif 2; other site 592205002389 motif 3; other site 592205002390 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 592205002391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002392 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 592205002393 Phosphopantetheine attachment site; Region: PP-binding; cl09936 592205002394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002395 Dynamin family; Region: Dynamin_N; pfam00350 592205002396 G1 box; other site 592205002397 GTP/Mg2+ binding site [chemical binding]; other site 592205002398 G2 box; other site 592205002399 Switch I region; other site 592205002400 G3 box; other site 592205002401 Switch II region; other site 592205002402 G4 box; other site 592205002403 G5 box; other site 592205002404 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 592205002405 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 592205002406 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205002407 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 592205002408 Outer membrane efflux protein; Region: OEP; pfam02321 592205002409 Outer membrane efflux protein; Region: OEP; pfam02321 592205002410 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 592205002411 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 592205002412 Sulfatase; Region: Sulfatase; cl10460 592205002413 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 592205002414 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 592205002415 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592205002416 inhibitor-cofactor binding pocket; inhibition site 592205002417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205002418 catalytic residue [active] 592205002419 SurA N-terminal domain; Region: SurA_N_3; cl07813 592205002420 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 592205002421 PPIC-type PPIASE domain; Region: Rotamase; cl08278 592205002422 cell division protein FtsA; Region: ftsA; TIGR01174 592205002423 Cell division protein FtsA; Region: FtsA; cl11496 592205002424 Cell division protein FtsA; Region: FtsA; cl11496 592205002425 cell division protein FtsZ; Validated; Region: PRK09330 592205002426 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 592205002427 nucleotide binding site [chemical binding]; other site 592205002428 SulA interaction site; other site 592205002429 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592205002430 active site 592205002431 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 592205002432 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592205002433 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 592205002434 Haemagglutinin; Region: Hemagglutinin; pfam00509 592205002435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002436 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 592205002437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002438 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 592205002439 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 592205002440 active site 592205002441 ATP binding site [chemical binding]; other site 592205002442 substrate binding site [chemical binding]; other site 592205002443 activation loop (A-loop); other site 592205002444 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 592205002445 metal ion-dependent adhesion site (MIDAS); other site 592205002446 Protein of unknown function DUF262; Region: DUF262; cl14890 592205002447 Protein of unknown function DUF262; Region: DUF262; cl14890 592205002448 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 592205002449 DHH family; Region: DHH; pfam01368 592205002450 arginine decarboxylase, biosynthetic; Region: speA; TIGR01273 592205002451 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 592205002452 active site 592205002453 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592205002454 catalytic residues [active] 592205002455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 592205002456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592205002457 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 592205002458 putative ADP-binding pocket [chemical binding]; other site 592205002459 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 592205002460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205002461 S-adenosylmethionine binding site [chemical binding]; other site 592205002462 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 592205002463 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 592205002464 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 592205002465 active site 592205002466 HIGH motif; other site 592205002467 KMSKS motif; other site 592205002468 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 592205002469 tRNA binding surface [nucleotide binding]; other site 592205002470 anticodon binding site; other site 592205002471 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 592205002472 dimer interface [polypeptide binding]; other site 592205002473 putative tRNA-binding site [nucleotide binding]; other site 592205002474 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 592205002475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205002476 S-adenosylmethionine binding site [chemical binding]; other site 592205002477 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592205002478 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 592205002479 GMP synthase; Reviewed; Region: guaA; PRK00074 592205002480 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 592205002481 AMP/PPi binding site [chemical binding]; other site 592205002482 candidate oxyanion hole; other site 592205002483 catalytic triad [active] 592205002484 potential glutamine specificity residues [chemical binding]; other site 592205002485 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 592205002486 ATP Binding subdomain [chemical binding]; other site 592205002487 Ligand Binding sites [chemical binding]; other site 592205002488 Dimerization subdomain; other site 592205002489 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 592205002490 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 592205002491 molybdopterin cofactor binding site [chemical binding]; other site 592205002492 substrate binding site [chemical binding]; other site 592205002493 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 592205002494 molybdopterin cofactor binding site; other site 592205002495 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 592205002496 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592205002497 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592205002498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592205002499 catalytic residue [active] 592205002500 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 592205002501 nucleotide binding site/active site [active] 592205002502 HIT family signature motif; other site 592205002503 catalytic residue [active] 592205002504 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 592205002505 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 592205002506 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 592205002507 dimer interface [polypeptide binding]; other site 592205002508 motif 1; other site 592205002509 active site 592205002510 motif 2; other site 592205002511 motif 3; other site 592205002512 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 592205002513 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 592205002514 putative tRNA-binding site [nucleotide binding]; other site 592205002515 tRNA synthetase B5 domain; Region: B5; cl08394 592205002516 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 592205002517 dimer interface [polypeptide binding]; other site 592205002518 motif 1; other site 592205002519 motif 3; other site 592205002520 motif 2; other site 592205002521 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 592205002522 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 592205002523 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 592205002524 hinge; other site 592205002525 active site 592205002526 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 592205002527 LytB protein; Region: LYTB; cl00507 592205002528 ribosomal protein S1; Region: rpsA; TIGR00717 592205002529 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 592205002530 RNA binding site [nucleotide binding]; other site 592205002531 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592205002532 RNA binding site [nucleotide binding]; other site 592205002533 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592205002534 RNA binding site [nucleotide binding]; other site 592205002535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592205002536 RNA binding site [nucleotide binding]; other site 592205002537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592205002538 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 592205002539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002540 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 592205002541 putative L-serine binding site [chemical binding]; other site 592205002542 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 592205002543 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 592205002544 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 592205002545 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592205002546 catalytic residue [active] 592205002547 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 592205002548 putative active site [active] 592205002549 putative metal binding site [ion binding]; other site 592205002550 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 592205002551 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592205002552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205002553 active site 592205002554 phosphorylation site [posttranslational modification] 592205002555 intermolecular recognition site; other site 592205002556 dimerization interface [polypeptide binding]; other site 592205002557 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592205002558 putative binding surface; other site 592205002559 active site 592205002560 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 592205002561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592205002562 ATP binding site [chemical binding]; other site 592205002563 Mg2+ binding site [ion binding]; other site 592205002564 G-X-G motif; other site 592205002565 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 592205002566 Response regulator receiver domain; Region: Response_reg; pfam00072 592205002567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205002568 active site 592205002569 phosphorylation site [posttranslational modification] 592205002570 intermolecular recognition site; other site 592205002571 dimerization interface [polypeptide binding]; other site 592205002572 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 592205002573 putative CheA interaction surface; other site 592205002574 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 592205002575 dimer interface [polypeptide binding]; other site 592205002576 catalytic triad [active] 592205002577 peroxidatic and resolving cysteines [active] 592205002578 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 592205002579 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 592205002580 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 592205002581 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 592205002582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205002583 S-adenosylmethionine binding site [chemical binding]; other site 592205002584 primosome assembly protein PriA; Validated; Region: PRK05580 592205002585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205002586 ATP binding site [chemical binding]; other site 592205002587 putative Mg++ binding site [ion binding]; other site 592205002588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002589 Sporulation related domain; Region: SPOR; cl10051 592205002590 Peptidase family M48; Region: Peptidase_M48; cl12018 592205002591 HemK family putative methylases; Region: hemK_fam; TIGR00536 592205002592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002593 glutamate dehydrogenase; Provisional; Region: PRK09414 592205002594 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592205002595 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 592205002596 NAD(P) binding site [chemical binding]; other site 592205002597 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 592205002598 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 592205002599 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 592205002600 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 592205002601 catalytic residues [active] 592205002602 ferrochelatase; Region: hemH; TIGR00109 592205002603 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 592205002604 C-terminal domain interface [polypeptide binding]; other site 592205002605 active site 592205002606 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 592205002607 active site 592205002608 N-terminal domain interface [polypeptide binding]; other site 592205002609 RNA methyltransferase, RsmE family; Region: TIGR00046 592205002610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 592205002611 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002612 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 592205002613 trimer interface [polypeptide binding]; other site 592205002614 active site 592205002615 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 592205002616 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592205002617 carboxyltransferase (CT) interaction site; other site 592205002618 biotinylation site [posttranslational modification]; other site 592205002619 biotin carboxylase; Validated; Region: PRK08462 592205002620 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592205002621 ATP-grasp domain; Region: ATP-grasp_4; cl03087 592205002622 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 592205002623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002624 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 592205002625 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592205002626 inhibitor-cofactor binding pocket; inhibition site 592205002627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205002628 catalytic residue [active] 592205002629 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 592205002630 dimer interface [polypeptide binding]; other site 592205002631 putative radical transfer pathway; other site 592205002632 diiron center [ion binding]; other site 592205002633 tyrosyl radical; other site 592205002634 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 592205002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205002636 S-adenosylmethionine binding site [chemical binding]; other site 592205002637 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 592205002638 pseudouridylate synthase I; Region: hisT_truA; TIGR00071 592205002639 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 592205002640 dimerization interface 3.5A [polypeptide binding]; other site 592205002641 active site 592205002642 UDP-glucose-4-epimerase; Region: galE; TIGR01179 592205002643 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 592205002644 NAD binding site [chemical binding]; other site 592205002645 homodimer interface [polypeptide binding]; other site 592205002646 active site 592205002647 substrate binding site [chemical binding]; other site 592205002648 AsmA-like C-terminal region; Region: AsmA_2; cl15864 592205002649 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 592205002650 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 592205002651 putative NAD(P) binding site [chemical binding]; other site 592205002652 homodimer interface [polypeptide binding]; other site 592205002653 homotetramer interface [polypeptide binding]; other site 592205002654 active site 592205002655 Sel1 repeat; Region: Sel1; cl02723 592205002656 Sel1 repeat; Region: Sel1; cl02723 592205002657 Sel1 repeat; Region: Sel1; cl02723 592205002658 Sel1 repeat; Region: Sel1; cl02723 592205002659 Sel1 repeat; Region: Sel1; cl02723 592205002660 Sel1 repeat; Region: Sel1; cl02723 592205002661 Entner-Doudoroff aldolase; Region: eda; TIGR01182 592205002662 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 592205002663 active site 592205002664 intersubunit interface [polypeptide binding]; other site 592205002665 catalytic residue [active] 592205002666 Dehydratase family; Region: ILVD_EDD; cl00340 592205002667 6-phosphogluconate dehydratase; Region: edd; TIGR01196 592205002668 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592205002669 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592205002670 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592205002671 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 592205002672 putative active site [active] 592205002673 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 592205002674 glucokinase, proteobacterial type; Region: glk; TIGR00749 592205002675 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592205002676 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592205002677 putative NAD(P) binding site [chemical binding]; other site 592205002678 putative substrate binding site [chemical binding]; other site 592205002679 catalytic Zn binding site [ion binding]; other site 592205002680 structural Zn binding site [ion binding]; other site 592205002681 dimer interface [polypeptide binding]; other site 592205002682 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 592205002683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592205002684 active site 592205002685 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002686 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 592205002687 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 592205002688 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 592205002689 4Fe-4S binding domain; Region: Fer4; cl02805 592205002690 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 592205002691 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 592205002692 dimer interface [polypeptide binding]; other site 592205002693 PYR/PP interface [polypeptide binding]; other site 592205002694 TPP binding site [chemical binding]; other site 592205002695 substrate binding site [chemical binding]; other site 592205002696 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592205002697 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 592205002698 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 592205002699 TPP-binding site [chemical binding]; other site 592205002700 putative dimer interface [polypeptide binding]; other site 592205002701 adenylosuccinate lyase; Provisional; Region: PRK08470 592205002702 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 592205002703 tetramer interface [polypeptide binding]; other site 592205002704 active site 592205002705 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 592205002706 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002707 excinuclease ABC subunit B; Provisional; Region: PRK05298 592205002708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205002709 ATP binding site [chemical binding]; other site 592205002710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592205002711 nucleotide binding region [chemical binding]; other site 592205002712 ATP-binding site [chemical binding]; other site 592205002713 Ultra-violet resistance protein B; Region: UvrB; pfam12344 592205002714 UvrB/uvrC motif; Region: UVR; pfam02151 592205002715 Sel1 repeat; Region: Sel1; cl02723 592205002716 Sel1 repeat; Region: Sel1; cl02723 592205002717 Sel1 repeat; Region: Sel1; cl02723 592205002718 Sel1 repeat; Region: Sel1; cl02723 592205002719 Sel1 repeat; Region: Sel1; cl02723 592205002720 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 592205002721 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 592205002722 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 592205002723 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205002724 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592205002725 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 592205002726 cofactor binding site; other site 592205002727 DNA binding site [nucleotide binding] 592205002728 substrate interaction site [chemical binding]; other site 592205002729 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 592205002730 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 592205002731 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 592205002732 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592205002733 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592205002734 ligand binding site [chemical binding]; other site 592205002735 translocation protein TolB; Provisional; Region: tolB; PRK04043 592205002736 TolB amino-terminal domain; Region: TolB_N; cl00639 592205002737 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592205002738 Gram-negative bacterial tonB protein; Region: TonB; cl10048 592205002739 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 592205002740 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592205002741 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 592205002742 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 592205002743 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 592205002744 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 592205002745 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 592205002746 alpha subunit interaction interface [polypeptide binding]; other site 592205002747 Walker A motif; other site 592205002748 ATP binding site [chemical binding]; other site 592205002749 Walker B motif; other site 592205002750 inhibitor binding site; inhibition site 592205002751 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592205002752 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 592205002753 ATP synthase; Region: ATP-synt; cl00365 592205002754 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 592205002755 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 592205002756 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 592205002757 beta subunit interaction interface [polypeptide binding]; other site 592205002758 Walker A motif; other site 592205002759 ATP binding site [chemical binding]; other site 592205002760 Walker B motif; other site 592205002761 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592205002762 Plant ATP synthase F0; Region: YMF19; cl07975 592205002763 Plant ATP synthase F0; Region: YMF19; cl07975 592205002764 Plant ATP synthase F0; Region: YMF19; cl07975 592205002765 ParB-like partition proteins; Region: parB_part; TIGR00180 592205002766 ParB-like nuclease domain; Region: ParBc; cl02129 592205002767 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592205002768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592205002769 P-loop; other site 592205002770 Magnesium ion binding site [ion binding]; other site 592205002771 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592205002772 Magnesium ion binding site [ion binding]; other site 592205002773 biotin--protein ligase; Provisional; Region: PRK08477 592205002774 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 592205002775 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 592205002776 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 592205002777 putative active site [active] 592205002778 substrate binding site [chemical binding]; other site 592205002779 putative cosubstrate binding site; other site 592205002780 catalytic site [active] 592205002781 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 592205002782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 592205002783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 592205002784 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 592205002785 Uncharacterized conserved protein [Function unknown]; Region: COG1432 592205002786 LabA_like proteins; Region: LabA_like; cd06167 592205002787 putative metal binding site [ion binding]; other site 592205002788 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 592205002789 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 592205002790 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 592205002791 RimM N-terminal domain; Region: RimM; pfam01782 592205002792 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 592205002793 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 592205002794 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 592205002795 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 592205002796 signal recognition particle protein; Provisional; Region: PRK10867 592205002797 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 592205002798 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592205002799 P loop; other site 592205002800 GTP binding site [chemical binding]; other site 592205002801 Signal peptide binding domain; Region: SRP_SPB; pfam02978 592205002802 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 592205002803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592205002804 active site 592205002805 HIGH motif; other site 592205002806 nucleotide binding site [chemical binding]; other site 592205002807 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592205002808 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 592205002809 active site 592205002810 KMSKS motif; other site 592205002811 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 592205002812 anticodon binding site; other site 592205002813 FliW protein; Region: FliW; cl00740 592205002814 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 592205002815 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 592205002816 active site 592205002817 homodimer interface [polypeptide binding]; other site 592205002818 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002819 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002820 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 592205002821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002822 Fic/DOC family; Region: Fic; cl00960 592205002823 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 592205002824 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 592205002825 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 592205002826 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 592205002827 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592205002828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592205002829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592205002830 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 592205002831 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 592205002832 active site 592205002833 dimer interface [polypeptide binding]; other site 592205002834 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 592205002835 dimer interface [polypeptide binding]; other site 592205002836 active site 592205002837 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 592205002838 carbon starvation protein A; Provisional; Region: PRK15015 592205002839 Carbon starvation protein CstA; Region: CstA; pfam02554 592205002840 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 592205002841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592205002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205002843 dimer interface [polypeptide binding]; other site 592205002844 conserved gate region; other site 592205002845 putative PBP binding loops; other site 592205002846 ABC-ATPase subunit interface; other site 592205002847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205002848 dimer interface [polypeptide binding]; other site 592205002849 conserved gate region; other site 592205002850 putative PBP binding loops; other site 592205002851 ABC-ATPase subunit interface; other site 592205002852 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592205002853 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 592205002854 Walker A/P-loop; other site 592205002855 ATP binding site [chemical binding]; other site 592205002856 Q-loop/lid; other site 592205002857 ABC transporter signature motif; other site 592205002858 Walker B; other site 592205002859 D-loop; other site 592205002860 H-loop/switch region; other site 592205002861 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592205002862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592205002863 substrate binding pocket [chemical binding]; other site 592205002864 membrane-bound complex binding site; other site 592205002865 hinge residues; other site 592205002866 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 592205002867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 592205002868 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592205002869 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205002870 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 592205002871 Sulfatase; Region: Sulfatase; cl10460 592205002872 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 592205002873 nucleoside transporter; Region: nupC; TIGR00804 592205002874 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592205002875 Nucleoside recognition; Region: Gate; cl00486 592205002876 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592205002877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592205002878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592205002879 putative substrate translocation pore; other site 592205002880 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 592205002881 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 592205002882 Ligand Binding Site [chemical binding]; other site 592205002883 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 592205002884 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 592205002885 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 592205002886 MatE; Region: MatE; cl10513 592205002887 MatE; Region: MatE; cl10513 592205002888 putative arabinose transporter; Provisional; Region: PRK03545 592205002889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592205002890 putative substrate translocation pore; other site 592205002891 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 592205002892 active site 592205002893 zinc binding site [ion binding]; other site 592205002894 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 592205002895 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 592205002896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205002897 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 592205002898 histidyl-tRNA synthetase; Region: hisS; TIGR00442 592205002899 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 592205002900 dimer interface [polypeptide binding]; other site 592205002901 motif 1; other site 592205002902 active site 592205002903 motif 2; other site 592205002904 motif 3; other site 592205002905 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 592205002906 anticodon binding site; other site 592205002907 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592205002908 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592205002909 putative active site [active] 592205002910 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 592205002911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592205002912 active site 592205002913 catalytic tetrad [active] 592205002914 elongation factor G; Reviewed; Region: PRK00007 592205002915 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 592205002916 G1 box; other site 592205002917 putative GEF interaction site [polypeptide binding]; other site 592205002918 GTP/Mg2+ binding site [chemical binding]; other site 592205002919 Switch I region; other site 592205002920 G2 box; other site 592205002921 G3 box; other site 592205002922 Switch II region; other site 592205002923 G4 box; other site 592205002924 G5 box; other site 592205002925 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 592205002926 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 592205002927 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 592205002928 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 592205002929 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 592205002930 S17 interaction site [polypeptide binding]; other site 592205002931 S8 interaction site; other site 592205002932 16S rRNA interaction site [nucleotide binding]; other site 592205002933 streptomycin interaction site [chemical binding]; other site 592205002934 23S rRNA interaction site [nucleotide binding]; other site 592205002935 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 592205002936 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 592205002937 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 592205002938 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 592205002939 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592205002940 RPB11 interaction site [polypeptide binding]; other site 592205002941 RPB12 interaction site [polypeptide binding]; other site 592205002942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592205002943 RPB3 interaction site [polypeptide binding]; other site 592205002944 RPB1 interaction site [polypeptide binding]; other site 592205002945 RPB11 interaction site [polypeptide binding]; other site 592205002946 RPB10 interaction site [polypeptide binding]; other site 592205002947 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 592205002948 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 592205002949 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 592205002950 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 592205002951 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 592205002952 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 592205002953 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 592205002954 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 592205002955 DNA binding site [nucleotide binding] 592205002956 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 592205002957 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 592205002958 core dimer interface [polypeptide binding]; other site 592205002959 peripheral dimer interface [polypeptide binding]; other site 592205002960 L10 interface [polypeptide binding]; other site 592205002961 L11 interface [polypeptide binding]; other site 592205002962 putative EF-Tu interaction site [polypeptide binding]; other site 592205002963 putative EF-G interaction site [polypeptide binding]; other site 592205002964 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 592205002965 23S rRNA interface [nucleotide binding]; other site 592205002966 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 592205002967 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 592205002968 mRNA/rRNA interface [nucleotide binding]; other site 592205002969 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 592205002970 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 592205002971 23S rRNA interface [nucleotide binding]; other site 592205002972 L7/L12 interface [polypeptide binding]; other site 592205002973 putative thiostrepton binding site; other site 592205002974 L25 interface [polypeptide binding]; other site 592205002975 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 592205002976 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 592205002977 putative homodimer interface [polypeptide binding]; other site 592205002978 KOW motif; Region: KOW; cl00354 592205002979 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 592205002980 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 592205002981 elongation factor Tu; Reviewed; Region: PRK00049 592205002982 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 592205002983 G1 box; other site 592205002984 GEF interaction site [polypeptide binding]; other site 592205002985 GTP/Mg2+ binding site [chemical binding]; other site 592205002986 Switch I region; other site 592205002987 G2 box; other site 592205002988 G3 box; other site 592205002989 Switch II region; other site 592205002990 G4 box; other site 592205002991 G5 box; other site 592205002992 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 592205002993 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 592205002994 Antibiotic Binding Site [chemical binding]; other site 592205002995 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592205002996 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205002997 Walker A/P-loop; other site 592205002998 ATP binding site [chemical binding]; other site 592205002999 Q-loop/lid; other site 592205003000 ABC transporter signature motif; other site 592205003001 Walker B; other site 592205003002 D-loop; other site 592205003003 H-loop/switch region; other site 592205003004 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 592205003005 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 592205003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003007 serine O-acetyltransferase; Region: cysE; TIGR01172 592205003008 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 592205003009 trimer interface [polypeptide binding]; other site 592205003010 active site 592205003011 substrate binding site [chemical binding]; other site 592205003012 CoA binding site [chemical binding]; other site 592205003013 ATP synthase subunit C; Region: ATP-synt_C; cl00466 592205003014 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 592205003015 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 592205003016 oligomer interface [polypeptide binding]; other site 592205003017 RNA binding site [nucleotide binding]; other site 592205003018 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 592205003019 oligomer interface [polypeptide binding]; other site 592205003020 RNA binding site [nucleotide binding]; other site 592205003021 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 592205003022 putative nucleic acid binding region [nucleotide binding]; other site 592205003023 G-X-X-G motif; other site 592205003024 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592205003025 RNA binding site [nucleotide binding]; other site 592205003026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 592205003027 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 592205003028 Organic solvent tolerance protein; Region: OstA_C; pfam04453 592205003029 RDD family; Region: RDD; cl00746 592205003030 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 592205003031 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 592205003032 ATP-grasp domain; Region: ATP-grasp_4; cl03087 592205003033 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 592205003034 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 592205003035 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 592205003036 Walker A/P-loop; other site 592205003037 ATP binding site [chemical binding]; other site 592205003038 Q-loop/lid; other site 592205003039 ABC transporter signature motif; other site 592205003040 Walker B; other site 592205003041 D-loop; other site 592205003042 H-loop/switch region; other site 592205003043 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 592205003044 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 592205003045 catalytic residue [active] 592205003046 putative FPP diphosphate binding site; other site 592205003047 putative FPP binding hydrophobic cleft; other site 592205003048 dimer interface [polypeptide binding]; other site 592205003049 putative IPP diphosphate binding site; other site 592205003050 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592205003051 FAD binding domain; Region: FAD_binding_4; pfam01565 592205003052 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592205003053 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592205003054 active site residue [active] 592205003055 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 592205003056 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592205003057 active site 592205003058 CrcB-like protein; Region: CRCB; cl09114 592205003059 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 592205003060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205003061 FeS/SAM binding site; other site 592205003062 HemN C-terminal domain; Region: HemN_C; pfam06969 592205003063 Cytochrome c; Region: Cytochrom_C; cl11414 592205003064 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 592205003065 putative active site [active] 592205003066 Ap4A binding site [chemical binding]; other site 592205003067 nudix motif; other site 592205003068 putative metal binding site [ion binding]; other site 592205003069 aspartate kinase; Reviewed; Region: PRK06635 592205003070 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 592205003071 putative nucleotide binding site [chemical binding]; other site 592205003072 putative catalytic residues [active] 592205003073 putative Mg ion binding site [ion binding]; other site 592205003074 putative aspartate binding site [chemical binding]; other site 592205003075 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 592205003076 putative allosteric regulatory site; other site 592205003077 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 592205003078 putative allosteric regulatory residue; other site 592205003079 DNA replication regulator; Region: HobA; pfam12163 592205003080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003081 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 592205003082 dihydropteroate synthase; Region: DHPS; TIGR01496 592205003083 substrate binding pocket [chemical binding]; other site 592205003084 dimer interface [polypeptide binding]; other site 592205003085 inhibitor binding site; inhibition site 592205003086 EamA-like transporter family; Region: EamA; cl01037 592205003087 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592205003088 EamA-like transporter family; Region: EamA; cl01037 592205003089 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 592205003090 Protein of unknown function (DUF507); Region: DUF507; cl01112 592205003091 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 592205003092 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 592205003093 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 592205003094 catalytic site [active] 592205003095 subunit interface [polypeptide binding]; other site 592205003096 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 592205003097 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592205003098 multimer interface [polypeptide binding]; other site 592205003099 active site 592205003100 catalytic triad [active] 592205003101 dimer interface [polypeptide binding]; other site 592205003102 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 592205003103 putative active site [active] 592205003104 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 592205003105 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 592205003106 motif 1; other site 592205003107 active site 592205003108 motif 2; other site 592205003109 motif 3; other site 592205003110 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 592205003111 DHHA1 domain; Region: DHHA1; pfam02272 592205003112 Protein of unknown function (DUF465); Region: DUF465; cl01070 592205003113 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 592205003114 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592205003115 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592205003116 dimer interface [polypeptide binding]; other site 592205003117 ssDNA binding site [nucleotide binding]; other site 592205003118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592205003119 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 592205003120 DNA polymerase III subunit delta; Validated; Region: PRK08487 592205003121 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 592205003122 Exoribonuclease R [Transcription]; Region: VacB; COG0557 592205003123 RNB domain; Region: RNB; pfam00773 592205003124 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 592205003125 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592205003126 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592205003127 shikimate binding site; other site 592205003128 NAD(P) binding site [chemical binding]; other site 592205003129 Bacterial SH3 domain; Region: SH3_3; cl02551 592205003130 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 592205003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592205003132 dimer interface [polypeptide binding]; other site 592205003133 conserved gate region; other site 592205003134 putative PBP binding loops; other site 592205003135 ABC-ATPase subunit interface; other site 592205003136 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 592205003137 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 592205003138 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 592205003139 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 592205003140 active site 592205003141 HIGH motif; other site 592205003142 dimer interface [polypeptide binding]; other site 592205003143 KMSKS motif; other site 592205003144 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 592205003145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205003146 S-adenosylmethionine binding site [chemical binding]; other site 592205003147 Preprotein translocase SecG subunit; Region: SecG; cl09123 592205003148 ribosome recycling factor; Reviewed; Region: frr; PRK00083 592205003149 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 592205003150 hinge region; other site 592205003151 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 592205003152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592205003153 active site 592205003154 RDD family; Region: RDD; cl00746 592205003155 NAD-dependent deacetylase; Provisional; Region: PRK00481 592205003156 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 592205003157 NAD+ binding site [chemical binding]; other site 592205003158 substrate binding site [chemical binding]; other site 592205003159 Zn binding site [ion binding]; other site 592205003160 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 592205003161 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 592205003162 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 592205003163 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 592205003164 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 592205003165 NADH dehydrogenase subunit G; Validated; Region: PRK08493 592205003166 NADH dehydrogenase subunit G; Validated; Region: PRK08493 592205003167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592205003168 catalytic loop [active] 592205003169 iron binding site [ion binding]; other site 592205003170 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 592205003171 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 592205003172 molybdopterin cofactor binding site; other site 592205003173 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 592205003174 NADH dehydrogenase; Region: NADHdh; cl00469 592205003175 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 592205003176 4Fe-4S binding domain; Region: Fer4; cl02805 592205003177 4Fe-4S binding domain; Region: Fer4; cl02805 592205003178 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 592205003179 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 592205003180 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 592205003181 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 592205003182 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 592205003183 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 592205003184 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 592205003185 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 592205003186 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 592205003187 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 592205003188 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 592205003189 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 592205003190 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 592205003191 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 592205003192 active site 592205003193 substrate binding site [chemical binding]; other site 592205003194 metal binding site [ion binding]; metal-binding site 592205003195 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 592205003196 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 592205003197 substrate binding site [chemical binding]; other site 592205003198 active site 592205003199 catalytic residues [active] 592205003200 heterodimer interface [polypeptide binding]; other site 592205003201 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 592205003202 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 592205003203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592205003204 catalytic residue [active] 592205003205 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 592205003206 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 592205003207 active site 592205003208 ribulose/triose binding site [chemical binding]; other site 592205003209 phosphate binding site [ion binding]; other site 592205003210 substrate (anthranilate) binding pocket [chemical binding]; other site 592205003211 product (indole) binding pocket [chemical binding]; other site 592205003212 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 592205003213 active site 592205003214 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592205003215 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 592205003216 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592205003217 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 592205003218 Glutamine amidotransferase class-I; Region: GATase; pfam00117 592205003219 glutamine binding [chemical binding]; other site 592205003220 catalytic triad [active] 592205003221 anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565 592205003222 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592205003223 chorismate binding enzyme; Region: Chorismate_bind; cl10555 592205003224 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592205003225 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592205003226 putative active site [active] 592205003227 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 592205003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592205003229 active site 592205003230 motif I; other site 592205003231 motif II; other site 592205003232 YceI-like domain; Region: YceI; cl01001 592205003233 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 592205003234 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 592205003235 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 592205003236 Thiamine pyrophosphokinase; Region: TPK; cd07995 592205003237 active site 592205003238 dimerization interface [polypeptide binding]; other site 592205003239 thiamine binding site [chemical binding]; other site 592205003240 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 592205003241 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 592205003242 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 592205003243 alphaNTD homodimer interface [polypeptide binding]; other site 592205003244 alphaNTD - beta interaction site [polypeptide binding]; other site 592205003245 alphaNTD - beta' interaction site [polypeptide binding]; other site 592205003246 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 592205003247 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 592205003248 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 592205003249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592205003250 RNA binding surface [nucleotide binding]; other site 592205003251 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 592205003252 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 592205003253 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 592205003254 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 592205003255 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 592205003256 rRNA binding site [nucleotide binding]; other site 592205003257 predicted 30S ribosome binding site; other site 592205003258 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592205003259 active site 592205003260 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 592205003261 SecY translocase; Region: SecY; pfam00344 592205003262 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 592205003263 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 592205003264 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 592205003265 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 592205003266 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 592205003267 23S rRNA interface [nucleotide binding]; other site 592205003268 5S rRNA interface [nucleotide binding]; other site 592205003269 L27 interface [polypeptide binding]; other site 592205003270 L5 interface [polypeptide binding]; other site 592205003271 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 592205003272 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592205003273 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 592205003274 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 592205003275 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 592205003276 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 592205003277 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 592205003278 KOW motif; Region: KOW; cl00354 592205003279 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 592205003280 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 592205003281 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 592205003282 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 592205003283 23S rRNA interface [nucleotide binding]; other site 592205003284 5S rRNA interface [nucleotide binding]; other site 592205003285 putative antibiotic binding site [chemical binding]; other site 592205003286 L25 interface [polypeptide binding]; other site 592205003287 L27 interface [polypeptide binding]; other site 592205003288 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 592205003289 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 592205003290 G-X-X-G motif; other site 592205003291 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 592205003292 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 592205003293 putative translocon binding site; other site 592205003294 protein-rRNA interface [nucleotide binding]; other site 592205003295 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 592205003296 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 592205003297 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 592205003298 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 592205003299 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 592205003300 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 592205003301 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 592205003302 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 592205003303 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 592205003304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003305 Helix-turn-helix domains; Region: HTH; cl00088 592205003306 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 592205003307 RNA/DNA hybrid binding site [nucleotide binding]; other site 592205003308 active site 592205003309 fumarate hydratase; Reviewed; Region: fumC; PRK00485 592205003310 Class II fumarases; Region: Fumarase_classII; cd01362 592205003311 active site 592205003312 tetramer interface [polypeptide binding]; other site 592205003313 FixH; Region: FixH; cl01254 592205003314 Outer membrane efflux protein; Region: OEP; pfam02321 592205003315 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 592205003316 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205003317 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 592205003318 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 592205003319 AzlC protein; Region: AzlC; cl00570 592205003320 chaperone protein DnaJ; Provisional; Region: PRK14288 592205003321 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592205003322 HSP70 interaction site [polypeptide binding]; other site 592205003323 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 592205003324 substrate binding site [polypeptide binding]; other site 592205003325 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 592205003326 Zn binding sites [ion binding]; other site 592205003327 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 592205003328 dimer interface [polypeptide binding]; other site 592205003329 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 592205003330 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 592205003331 Ligand Binding Site [chemical binding]; other site 592205003332 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592205003333 HSP70 interaction site [polypeptide binding]; other site 592205003334 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 592205003335 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 592205003336 active site 592205003337 (T/H)XGH motif; other site 592205003338 nickel responsive regulator; Provisional; Region: PRK00630 592205003339 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 592205003340 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 592205003341 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592205003342 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 592205003343 Gram-negative bacterial tonB protein; Region: TonB; cl10048 592205003344 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003345 Integral membrane protein TerC family; Region: TerC; cl10468 592205003346 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 592205003347 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 592205003348 Phosphoglycerate kinase; Region: PGK; pfam00162 592205003349 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 592205003350 substrate binding site [chemical binding]; other site 592205003351 hinge regions; other site 592205003352 ADP binding site [chemical binding]; other site 592205003353 catalytic site [active] 592205003354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003355 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 592205003356 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 592205003357 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 592205003358 ligand binding site [chemical binding]; other site 592205003359 active site 592205003360 UGI interface [polypeptide binding]; other site 592205003361 catalytic site [active] 592205003362 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592205003363 putative acyl-acceptor binding pocket; other site 592205003364 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592205003365 C-terminal peptidase (prc); Region: prc; TIGR00225 592205003366 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592205003367 protein binding site [polypeptide binding]; other site 592205003368 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592205003369 Catalytic dyad [active] 592205003370 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 592205003371 YcfA-like protein; Region: YcfA; cl00752 592205003372 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 592205003373 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592205003374 DNA binding residues [nucleotide binding] 592205003375 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 592205003376 catalytic residues [active] 592205003377 catalytic nucleophile [active] 592205003378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 592205003379 Probable transposase; Region: OrfB_IS605; pfam01385 592205003380 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 592205003381 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 592205003382 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592205003383 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592205003384 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 592205003385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003386 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 592205003387 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 592205003388 dimerization interface [polypeptide binding]; other site 592205003389 active site 592205003390 Quinolinate synthetase A protein; Region: NadA; cl00420 592205003391 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 592205003392 UbiA prenyltransferase family; Region: UbiA; cl00337 592205003393 Competence protein; Region: Competence; cl00471 592205003394 replicative DNA helicase; Provisional; Region: PRK08506 592205003395 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 592205003396 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 592205003397 Walker A motif; other site 592205003398 ATP binding site [chemical binding]; other site 592205003399 Walker B motif; other site 592205003400 DNA binding loops [nucleotide binding] 592205003401 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 592205003402 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 592205003403 putative substrate binding site [chemical binding]; other site 592205003404 putative ATP binding site [chemical binding]; other site 592205003405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 592205003406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592205003407 ATP binding site [chemical binding]; other site 592205003408 Mg2+ binding site [ion binding]; other site 592205003409 G-X-G motif; other site 592205003410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592205003411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592205003412 active site 592205003413 phosphorylation site [posttranslational modification] 592205003414 intermolecular recognition site; other site 592205003415 dimerization interface [polypeptide binding]; other site 592205003416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592205003417 DNA binding site [nucleotide binding] 592205003418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003419 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592205003420 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 592205003421 rod shape-determining protein MreC; Region: MreC; pfam04085 592205003422 rod shape-determining protein MreB; Provisional; Region: PRK13927 592205003423 Cell division protein FtsA; Region: FtsA; cl11496 592205003424 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 592205003425 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 592205003426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205003428 Walker A motif; other site 592205003429 ATP binding site [chemical binding]; other site 592205003430 Walker B motif; other site 592205003431 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 592205003432 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 592205003433 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 592205003434 active site 592205003435 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592205003436 FliW protein; Region: FliW; cl00740 592205003437 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 592205003438 ATP-dependent protease La; Region: lon; TIGR00763 592205003439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205003440 Walker A motif; other site 592205003441 ATP binding site [chemical binding]; other site 592205003442 Walker B motif; other site 592205003443 arginine finger; other site 592205003444 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 592205003445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003446 Prephenate dehydrogenase; Region: PDH; pfam02153 592205003447 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 592205003448 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 592205003449 active site 592205003450 substrate binding site [chemical binding]; other site 592205003451 Mg2+ binding site [ion binding]; other site 592205003452 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 592205003453 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 592205003454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 592205003458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003459 biotin synthase; Provisional; Region: PRK08508 592205003460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592205003461 FeS/SAM binding site; other site 592205003462 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 592205003463 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 592205003464 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592205003465 Oligomerisation domain; Region: Oligomerisation; cl00519 592205003466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003467 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 592205003468 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 592205003469 Ligand binding site; other site 592205003470 metal-binding site 592205003471 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 592205003472 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 592205003473 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 592205003474 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 592205003475 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 592205003476 Walker A motif/ATP binding site; other site 592205003477 Walker B motif; other site 592205003478 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 592205003479 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 592205003480 ATP binding site [chemical binding]; other site 592205003481 Walker A motif; other site 592205003482 hexamer interface [polypeptide binding]; other site 592205003483 Walker B motif; other site 592205003484 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 592205003485 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592205003486 active site 592205003487 HIGH motif; other site 592205003488 nucleotide binding site [chemical binding]; other site 592205003489 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 592205003490 active site 592205003491 KMSKS motif; other site 592205003492 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 592205003493 tRNA binding surface [nucleotide binding]; other site 592205003494 anticodon binding site; other site 592205003495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592205003496 RNA binding surface [nucleotide binding]; other site 592205003497 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 592205003498 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 592205003499 KpsF/GutQ family protein; Region: kpsF; TIGR00393 592205003500 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 592205003501 putative active site [active] 592205003502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 592205003503 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 592205003504 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 592205003505 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 592205003506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003507 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205003508 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 592205003509 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205003510 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 592205003511 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 592205003512 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 592205003513 active site 592205003514 substrate binding site [chemical binding]; other site 592205003515 cosubstrate binding site; other site 592205003516 catalytic site [active] 592205003517 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 592205003518 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 592205003519 tandem repeat interface [polypeptide binding]; other site 592205003520 oligomer interface [polypeptide binding]; other site 592205003521 active site residues [active] 592205003522 TIR domain; Region: TIR_2; cl15770 592205003523 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 592205003524 active site 592205003525 Global regulator protein family; Region: CsrA; cl00670 592205003526 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 592205003527 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 592205003528 SmpB-tmRNA interface; other site 592205003529 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592205003530 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 592205003531 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 592205003532 Ribonuclease P; Region: Ribonuclease_P; cl00457 592205003533 Haemolytic domain; Region: Haemolytic; cl00506 592205003534 membrane protein insertase; Provisional; Region: PRK01318 592205003535 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 592205003536 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 592205003537 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 592205003538 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 592205003539 trmE is a tRNA modification GTPase; Region: trmE; cd04164 592205003540 G1 box; other site 592205003541 GTP/Mg2+ binding site [chemical binding]; other site 592205003542 Switch I region; other site 592205003543 G2 box; other site 592205003544 Switch II region; other site 592205003545 G3 box; other site 592205003546 G4 box; other site 592205003547 G5 box; other site 592205003548 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 592205003549 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003550 LPP20 lipoprotein; Region: LPP20; cl15824 592205003551 TolB amino-terminal domain; Region: TolB_N; cl00639 592205003552 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592205003553 catalytic residues [active] 592205003554 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592205003555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592205003556 RNA binding surface [nucleotide binding]; other site 592205003557 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 592205003558 active site 592205003559 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 592205003560 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 592205003561 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 592205003562 generic binding surface I; other site 592205003563 generic binding surface II; other site 592205003564 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 592205003565 META domain; Region: META; cl01245 592205003566 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 592205003567 mce related protein; Region: MCE; pfam02470 592205003568 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 592205003569 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 592205003570 Walker A/P-loop; other site 592205003571 ATP binding site [chemical binding]; other site 592205003572 Q-loop/lid; other site 592205003573 ABC transporter signature motif; other site 592205003574 Walker B; other site 592205003575 D-loop; other site 592205003576 H-loop/switch region; other site 592205003577 Permease; Region: Permease; cl00510 592205003578 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003579 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 592205003580 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 592205003581 homodimer interface [polypeptide binding]; other site 592205003582 substrate-cofactor binding pocket; other site 592205003583 catalytic residue [active] 592205003584 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003585 DNA polymerase I; Region: pola; TIGR00593 592205003586 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592205003587 active site 592205003588 metal binding site 1 [ion binding]; metal-binding site 592205003589 putative 5' ssDNA interaction site; other site 592205003590 metal binding site 3; metal-binding site 592205003591 metal binding site 2 [ion binding]; metal-binding site 592205003592 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592205003593 putative DNA binding site [nucleotide binding]; other site 592205003594 putative metal binding site [ion binding]; other site 592205003595 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 592205003596 active site 592205003597 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 592205003598 active site 592205003599 DNA binding site [nucleotide binding] 592205003600 catalytic site [active] 592205003601 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 592205003602 thymidylate kinase; Validated; Region: tmk; PRK00698 592205003603 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 592205003604 TMP-binding site; other site 592205003605 ATP-binding site [chemical binding]; other site 592205003606 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 592205003607 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 592205003608 active site 592205003609 (T/H)XGH motif; other site 592205003610 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 592205003611 Flavoprotein; Region: Flavoprotein; cl08021 592205003612 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 592205003613 SAF domain; Region: SAF; cl00555 592205003614 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 592205003615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003616 Family description; Region: UvrD_C_2; cl15862 592205003617 Tetratricopeptide repeat; Region: TPR_9; pfam13371 592205003618 TPR repeat; Region: TPR_11; pfam13414 592205003619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592205003620 TPR motif; other site 592205003621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592205003622 binding surface 592205003623 TPR motif; other site 592205003624 seryl-tRNA synthetase; Provisional; Region: PRK05431 592205003625 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 592205003626 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 592205003627 dimer interface [polypeptide binding]; other site 592205003628 active site 592205003629 motif 1; other site 592205003630 motif 2; other site 592205003631 motif 3; other site 592205003632 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592205003633 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 592205003634 active site 592205003635 catalytic triad [active] 592205003636 dimer interface [polypeptide binding]; other site 592205003637 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 592205003638 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 592205003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205003640 S-adenosylmethionine binding site [chemical binding]; other site 592205003641 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 592205003642 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 592205003643 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 592205003644 ABC-2 type transporter; Region: ABC2_membrane; cl11417 592205003645 Predicted membrane protein [Function unknown]; Region: COG1511 592205003646 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 592205003647 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 592205003648 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205003649 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 592205003650 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592205003651 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592205003652 Domain of unknown function DUF21; Region: DUF21; pfam01595 592205003653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592205003654 Transporter associated domain; Region: CorC_HlyC; cl08393 592205003655 Phosphate transporter family; Region: PHO4; cl00396 592205003656 Phosphate transporter family; Region: PHO4; cl00396 592205003657 NifU-like domain; Region: NifU; cl00484 592205003658 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 592205003659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592205003660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592205003661 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 592205003662 putative active site [active] 592205003663 transaldolase; Provisional; Region: PRK03903 592205003664 catalytic residue [active] 592205003665 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 592205003666 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 592205003667 5S rRNA interface [nucleotide binding]; other site 592205003668 CTC domain interface [polypeptide binding]; other site 592205003669 L16 interface [polypeptide binding]; other site 592205003670 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 592205003671 putative active site [active] 592205003672 catalytic residue [active] 592205003673 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 592205003674 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592205003675 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 592205003676 PLD-like domain; Region: PLDc_2; pfam13091 592205003677 homodimer interface [polypeptide binding]; other site 592205003678 putative active site [active] 592205003679 catalytic site [active] 592205003680 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 592205003682 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 592205003683 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592205003684 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592205003685 metal-binding site [ion binding] 592205003686 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592205003687 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 592205003688 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 592205003689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592205003690 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 592205003691 catalytic motif [active] 592205003692 Zn binding site [ion binding]; other site 592205003693 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 592205003694 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 592205003695 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 592205003696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003697 NAD(P) binding pocket [chemical binding]; other site 592205003698 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 592205003699 4Fe-4S binding domain; Region: Fer4_5; pfam12801 592205003700 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 592205003701 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 592205003702 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592205003703 active site 592205003704 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 592205003705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 592205003706 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592205003707 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 592205003708 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 592205003709 NusA N-terminal domain; Region: NusA_N; pfam08529 592205003710 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 592205003711 RNA binding site [nucleotide binding]; other site 592205003712 homodimer interface [polypeptide binding]; other site 592205003713 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 592205003714 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 592205003715 G-X-X-G motif; other site 592205003716 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 592205003717 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 592205003718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003719 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 592205003720 Restriction endonuclease [Defense mechanisms]; Region: COG3587 592205003721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205003722 ATP binding site [chemical binding]; other site 592205003723 putative Mg++ binding site [ion binding]; other site 592205003724 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 592205003725 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 592205003726 ssDNA binding site; other site 592205003727 generic binding surface II; other site 592205003728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205003729 ATP binding site [chemical binding]; other site 592205003730 putative Mg++ binding site [ion binding]; other site 592205003731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592205003732 nucleotide binding region [chemical binding]; other site 592205003733 ATP-binding site [chemical binding]; other site 592205003734 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003735 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 592205003736 active site 592205003737 DNA binding site [nucleotide binding] 592205003738 putative phosphate binding site [ion binding]; other site 592205003739 putative catalytic site [active] 592205003740 metal binding site A [ion binding]; metal-binding site 592205003741 AP binding site [nucleotide binding]; other site 592205003742 metal binding site B [ion binding]; metal-binding site 592205003743 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 592205003744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592205003745 Walker A motif; other site 592205003746 ATP binding site [chemical binding]; other site 592205003747 Walker B motif; other site 592205003748 arginine finger; other site 592205003749 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 592205003750 DnaA box-binding interface [nucleotide binding]; other site 592205003751 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 592205003752 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 592205003753 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 592205003754 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 592205003755 glutaminase active site [active] 592205003756 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 592205003757 dimer interface [polypeptide binding]; other site 592205003758 active site 592205003759 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 592205003760 dimer interface [polypeptide binding]; other site 592205003761 active site 592205003762 Thymidylate synthase complementing protein; Region: Thy1; cl03630 592205003763 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205003764 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 592205003765 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592205003766 HsdM N-terminal domain; Region: HsdM_N; pfam12161 592205003767 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 592205003768 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 592205003769 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 592205003770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205003771 ATP binding site [chemical binding]; other site 592205003772 putative Mg++ binding site [ion binding]; other site 592205003773 Protein of unknown function DUF45; Region: DUF45; cl00636 592205003774 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 592205003775 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592205003776 N-terminal plug; other site 592205003777 ligand-binding site [chemical binding]; other site 592205003778 Arginase family; Region: Arginase; cl00306 592205003779 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 592205003780 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 592205003781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003782 Protein of unknown function DUF262; Region: DUF262; cl14890 592205003783 Protein of unknown function DUF262; Region: DUF262; cl14890 592205003784 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 592205003785 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 592205003786 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 592205003787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 592205003788 Walker A/P-loop; other site 592205003789 ATP binding site [chemical binding]; other site 592205003790 Q-loop/lid; other site 592205003791 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 592205003792 ABC transporter signature motif; other site 592205003793 Walker B; other site 592205003794 D-loop; other site 592205003795 H-loop/switch region; other site 592205003796 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 592205003797 Domain of unknown function (DUF814); Region: DUF814; pfam05670 592205003798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592205003799 DNA binding site [nucleotide binding] 592205003800 Int/Topo IB signature motif; other site 592205003801 active site 592205003802 Helix-turn-helix domains; Region: HTH; cl00088 592205003803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 592205003804 Probable transposase; Region: OrfB_IS605; pfam01385 592205003805 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 592205003806 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 592205003807 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 592205003808 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592205003809 DNA binding residues [nucleotide binding] 592205003810 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 592205003811 catalytic residues [active] 592205003812 catalytic nucleophile [active] 592205003813 YcfA-like protein; Region: YcfA; cl00752 592205003814 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 592205003815 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 592205003816 Sel1 repeat; Region: Sel1; cl02723 592205003817 Sel1 repeat; Region: Sel1; cl02723 592205003818 Sel1 repeat; Region: Sel1; cl02723 592205003819 Sel1 repeat; Region: Sel1; cl02723 592205003820 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 592205003821 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592205003822 active site 592205003823 substrate binding site [chemical binding]; other site 592205003824 catalytic site [active] 592205003825 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 592205003826 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 592205003827 substrate binding site [chemical binding]; other site 592205003828 hexamer interface [polypeptide binding]; other site 592205003829 metal binding site [ion binding]; metal-binding site 592205003830 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 592205003831 active site 592205003832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592205003833 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 592205003834 Cytochrome c; Region: Cytochrom_C; cl11414 592205003835 Cytochrome c; Region: Cytochrom_C; cl11414 592205003836 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 592205003837 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 592205003838 intrachain domain interface; other site 592205003839 interchain domain interface [polypeptide binding]; other site 592205003840 heme bH binding site [chemical binding]; other site 592205003841 Qi binding site; other site 592205003842 heme bL binding site [chemical binding]; other site 592205003843 Qo binding site; other site 592205003844 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 592205003845 interchain domain interface [polypeptide binding]; other site 592205003846 intrachain domain interface; other site 592205003847 Qi binding site; other site 592205003848 Qo binding site; other site 592205003849 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 592205003850 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 592205003851 [2Fe-2S] cluster binding site [ion binding]; other site 592205003852 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 592205003853 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 592205003854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592205003855 ATP binding site [chemical binding]; other site 592205003856 putative Mg++ binding site [ion binding]; other site 592205003857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592205003858 nucleotide binding region [chemical binding]; other site 592205003859 ATP-binding site [chemical binding]; other site 592205003860 TRCF domain; Region: TRCF; cl04088 592205003861 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 592205003862 Peptidase family M23; Region: Peptidase_M23; pfam01551 592205003863 Peptidase family M23; Region: Peptidase_M23; pfam01551 592205003864 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 592205003865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592205003866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592205003867 Lipopolysaccharide-assembly; Region: LptE; cl01125 592205003868 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 592205003869 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 592205003870 HIGH motif; other site 592205003871 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592205003872 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 592205003873 active site 592205003874 KMSKS motif; other site 592205003875 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 592205003876 tRNA binding surface [nucleotide binding]; other site 592205003877 anticodon binding site; other site 592205003878 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 592205003879 Protein export membrane protein; Region: SecD_SecF; cl14618 592205003880 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 592205003881 Protein export membrane protein; Region: SecD_SecF; cl14618 592205003882 Preprotein translocase subunit; Region: YajC; cl00806 592205003883 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 592205003884 putative recombination protein RecB; Provisional; Region: PRK13909 592205003885 Family description; Region: UvrD_C_2; cl15862 592205003886 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 592205003887 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 592205003888 rRNA interaction site [nucleotide binding]; other site 592205003889 S8 interaction site; other site 592205003890 putative laminin-1 binding site; other site 592205003891 elongation factor Ts; Provisional; Region: tsf; PRK09377 592205003892 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 592205003893 Elongation factor TS; Region: EF_TS; pfam00889 592205003894 Elongation factor TS; Region: EF_TS; pfam00889 592205003895 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592205003896 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592205003897 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 592205003898 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 592205003899 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 592205003900 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 592205003901 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205003902 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 592205003903 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 592205003904 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 592205003905 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 592205003906 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 592205003907 putative ligand binding site [chemical binding]; other site 592205003908 peroxidase; Provisional; Region: PRK15000 592205003909 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 592205003910 dimer interface [polypeptide binding]; other site 592205003911 decamer (pentamer of dimers) interface [polypeptide binding]; other site 592205003912 catalytic triad [active] 592205003913 peroxidatic and resolving cysteines [active] 592205003914 NMT1-like family; Region: NMT1_2; cl15260 592205003915 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 592205003916 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592205003917 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 592205003918 Predicted GTPase [General function prediction only]; Region: COG0218 592205003919 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 592205003920 G1 box; other site 592205003921 GTP/Mg2+ binding site [chemical binding]; other site 592205003922 Switch I region; other site 592205003923 G2 box; other site 592205003924 G3 box; other site 592205003925 Switch II region; other site 592205003926 G4 box; other site 592205003927 G5 box; other site 592205003928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 592205003929 OstA-like protein; Region: OstA; cl00844 592205003930 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 592205003931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592205003932 motif II; other site 592205003933 rare lipoprotein A; Region: rlpA; TIGR00413 592205003934 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 592205003935 Sporulation related domain; Region: SPOR; cl10051 592205003936 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 592205003937 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592205003938 catalytic residue [active] 592205003939 autolysin; Reviewed; Region: PRK06347 592205003940 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 592205003941 putative peptidoglycan binding site; other site 592205003942 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592205003943 active site 592205003944 riboflavin synthase, alpha subunit; Region: ribE; TIGR00187 592205003945 Lumazine binding domain; Region: Lum_binding; pfam00677 592205003946 Lumazine binding domain; Region: Lum_binding; pfam00677 592205003947 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 592205003948 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592205003949 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 592205003950 Walker A/P-loop; other site 592205003951 ATP binding site [chemical binding]; other site 592205003952 Q-loop/lid; other site 592205003953 ABC transporter signature motif; other site 592205003954 Walker B; other site 592205003955 D-loop; other site 592205003956 H-loop/switch region; other site 592205003957 NIL domain; Region: NIL; cl09633 592205003958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592205003959 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 592205003960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592205003961 active site 592205003962 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 592205003963 active site 592205003964 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 592205003965 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 592205003966 Mg++ binding site [ion binding]; other site 592205003967 putative catalytic motif [active] 592205003968 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 592205003969 active site 592205003970 hydrophilic channel; other site 592205003971 dimerization interface [polypeptide binding]; other site 592205003972 catalytic residues [active] 592205003973 active site lid [active] 592205003974 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 592205003975 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 592205003976 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 592205003977 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 592205003978 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 592205003979 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 592205003980 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592205003981 hypothetical protein; Provisional; Region: PRK10236 592205003982 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 592205003983 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 592205003984 hypothetical protein; Provisional; Region: PRK10236 592205003985 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 592205003986 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045