-- dump date 20111121_012547 -- class Genbank::misc_feature -- table misc_feature_note -- id note 765962000001 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 765962000002 putative RNA binding site [nucleotide binding]; other site 765962000003 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 765962000004 homopentamer interface [polypeptide binding]; other site 765962000005 active site 765962000006 NeuB family; Region: NeuB; cl00496 765962000007 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 765962000008 active site clefts [active] 765962000009 zinc binding site [ion binding]; other site 765962000010 dimer interface [polypeptide binding]; other site 765962000011 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 765962000012 active site 765962000013 dimer interface [polypeptide binding]; other site 765962000014 pantoate--beta-alanine ligase; Region: panC; TIGR00018 765962000015 Pantoate-beta-alanine ligase; Region: PanC; cd00560 765962000016 active site 765962000017 ATP-binding site [chemical binding]; other site 765962000018 pantoate-binding site; other site 765962000019 HXXH motif; other site 765962000020 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000021 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765962000022 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765962000023 ring oligomerisation interface [polypeptide binding]; other site 765962000024 ATP/Mg binding site [chemical binding]; other site 765962000025 stacking interactions; other site 765962000026 hinge regions; other site 765962000027 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 765962000028 oligomerisation interface [polypeptide binding]; other site 765962000029 mobile loop; other site 765962000030 roof hairpin; other site 765962000031 DNA primase, catalytic core; Region: dnaG; TIGR01391 765962000032 CHC2 zinc finger; Region: zf-CHC2; cl02597 765962000033 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765962000034 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 765962000035 active site 765962000036 metal binding site [ion binding]; metal-binding site 765962000037 interdomain interaction site; other site 765962000038 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 765962000039 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 765962000040 Ligand Binding Site [chemical binding]; other site 765962000041 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 765962000042 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 765962000043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962000044 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 765962000045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 765962000046 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 765962000047 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 765962000048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962000049 active site 765962000050 phosphorylation site [posttranslational modification] 765962000051 intermolecular recognition site; other site 765962000052 dimerization interface [polypeptide binding]; other site 765962000053 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 765962000054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 765962000055 dimer interface [polypeptide binding]; other site 765962000056 active site 765962000057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765962000058 catalytic residues [active] 765962000059 substrate binding site [chemical binding]; other site 765962000060 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 765962000061 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 765962000062 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 765962000063 Sulfatase; Region: Sulfatase; cl10460 765962000064 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000065 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 765962000066 dimer interface [polypeptide binding]; other site 765962000067 Citrate synthase; Region: Citrate_synt; pfam00285 765962000068 active site 765962000069 citrylCoA binding site [chemical binding]; other site 765962000070 NADH binding [chemical binding]; other site 765962000071 cationic pore residues; other site 765962000072 oxalacetate/citrate binding site [chemical binding]; other site 765962000073 coenzyme A binding site [chemical binding]; other site 765962000074 catalytic triad [active] 765962000075 isocitrate dehydrogenase; Validated; Region: PRK07362 765962000076 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 765962000077 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 765962000078 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962000079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765962000080 Ligand Binding Site [chemical binding]; other site 765962000081 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 765962000082 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 765962000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000084 Walker A motif; other site 765962000085 ATP binding site [chemical binding]; other site 765962000086 Walker B motif; other site 765962000087 arginine finger; other site 765962000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000089 Walker A motif; other site 765962000090 ATP binding site [chemical binding]; other site 765962000091 Walker B motif; other site 765962000092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765962000093 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 765962000094 tetramerization interface [polypeptide binding]; other site 765962000095 active site 765962000096 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 765962000097 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 765962000098 protein binding site [polypeptide binding]; other site 765962000099 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 765962000100 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 765962000101 VirB8 protein; Region: VirB8; cl01500 765962000102 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 765962000103 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 765962000104 VirB7 interaction site; other site 765962000105 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 765962000106 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 765962000107 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 765962000108 Substrate binding site [chemical binding]; other site 765962000109 Cupin domain; Region: Cupin_2; cl09118 765962000110 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 765962000111 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 765962000112 NADP-binding site; other site 765962000113 homotetramer interface [polypeptide binding]; other site 765962000114 substrate binding site [chemical binding]; other site 765962000115 homodimer interface [polypeptide binding]; other site 765962000116 active site 765962000117 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 765962000118 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 765962000119 NADP binding site [chemical binding]; other site 765962000120 active site 765962000121 putative substrate binding site [chemical binding]; other site 765962000122 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 765962000123 dimerization interface [polypeptide binding]; other site 765962000124 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 765962000125 ATP binding site [chemical binding]; other site 765962000126 Acylphosphatase; Region: Acylphosphatase; cl00551 765962000127 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 765962000128 HypF finger; Region: zf-HYPF; pfam07503 765962000129 HypF finger; Region: zf-HYPF; pfam07503 765962000130 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 765962000131 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 765962000132 agmatine deiminase; Region: agmatine_aguA; TIGR03380 765962000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000134 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 765962000135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000136 cofactor binding site; other site 765962000137 DNA binding site [nucleotide binding] 765962000138 substrate interaction site [chemical binding]; other site 765962000139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000140 potential frameshift: common BLAST hit: gi|210134247|ref|YP_002300686.1| restriction endonuclease 765962000141 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 765962000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000143 cofactor binding site; other site 765962000144 DNA binding site [nucleotide binding] 765962000145 substrate interaction site [chemical binding]; other site 765962000146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000147 Sodium:solute symporter family; Region: SSF; cl00456 765962000148 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 765962000149 Proline dehydrogenase; Region: Pro_dh; cl03282 765962000150 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 765962000151 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765962000152 Glutamate binding site [chemical binding]; other site 765962000153 NAD binding site [chemical binding]; other site 765962000154 catalytic residues [active] 765962000155 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 765962000156 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765962000157 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 765962000158 potential frameshift: common BLAST hit: gi|15644696|ref|NP_206866.1| ATP-binding protein 765962000159 UreD urease accessory protein; Region: UreD; cl00530 765962000160 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962000161 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 765962000162 UreF; Region: UreF; pfam01730 765962000163 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 765962000164 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 765962000165 dimer interface [polypeptide binding]; other site 765962000166 catalytic residues [active] 765962000167 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 765962000168 urease subunit beta; Provisional; Region: ureB; PRK13985 765962000169 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 765962000170 subunit interactions [polypeptide binding]; other site 765962000171 active site 765962000172 flap region; other site 765962000173 urease subunit alpha; Provisional; Region: PRK13986 765962000174 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 765962000175 alpha-gamma subunit interface [polypeptide binding]; other site 765962000176 beta-gamma subunit interface [polypeptide binding]; other site 765962000177 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 765962000178 gamma-beta subunit interface [polypeptide binding]; other site 765962000179 alpha-beta subunit interface [polypeptide binding]; other site 765962000180 potential protein location (hypothetical protein HPSJM_00425 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-V) 765962000181 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 765962000182 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 765962000183 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 765962000184 active site 765962000185 substrate binding site [chemical binding]; other site 765962000186 metal binding site [ion binding]; metal-binding site 765962000187 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 765962000188 peptide chain release factor 1; Validated; Region: prfA; PRK00591 765962000189 RF-1 domain; Region: RF-1; cl02875 765962000190 RF-1 domain; Region: RF-1; cl02875 765962000191 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000192 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 765962000193 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 765962000194 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 765962000195 23S rRNA interface [nucleotide binding]; other site 765962000196 L3 interface [polypeptide binding]; other site 765962000197 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 765962000198 Predicted dehydrogenase [General function prediction only]; Region: COG0579 765962000199 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 765962000200 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 765962000201 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 765962000202 NlpC/P60 family; Region: NLPC_P60; cl11438 765962000203 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 765962000204 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 765962000205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765962000206 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 765962000207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 765962000208 DNA binding residues [nucleotide binding] 765962000209 5'-methylthioadenosine nucleosidase; Region: PLN02584 765962000210 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 765962000211 Acyl transferase domain; Region: Acyl_transf_1; cl08282 765962000212 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 765962000213 potential protein location (hypothetical protein HPSJM_00515 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-S) 765962000214 Protein of unknown function (DUF511); Region: DUF511; cl01114 765962000215 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 765962000216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000217 potential frameshift: common BLAST hit: gi|15611156|ref|NP_222807.1| putative alpha(1, 2)fucosyltransferase 765962000218 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 765962000219 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 765962000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962000221 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 765962000222 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 765962000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962000224 catalytic residue [active] 765962000225 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 765962000226 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 765962000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 765962000228 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 765962000229 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000230 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 765962000231 metal binding site [ion binding]; metal-binding site 765962000232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 765962000233 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 765962000234 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765962000235 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 765962000236 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 765962000237 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 765962000238 active site 765962000239 metal binding site [ion binding]; metal-binding site 765962000240 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 765962000241 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 765962000242 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 765962000243 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 765962000244 homodimer interface [polypeptide binding]; other site 765962000245 substrate-cofactor binding pocket; other site 765962000246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962000247 catalytic residue [active] 765962000248 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 765962000249 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 765962000250 dimer interface [polypeptide binding]; other site 765962000251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962000252 catalytic residue [active] 765962000253 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 765962000254 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 765962000255 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 765962000256 dimer interface [polypeptide binding]; other site 765962000257 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 765962000258 heat-inducible transcription repressor; Provisional; Region: PRK03911 765962000259 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 765962000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 765962000261 flagellin B; Provisional; Region: PRK13588 765962000262 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 765962000263 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 765962000264 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 765962000265 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 765962000266 DNA topoisomerase I; Validated; Region: PRK05582 765962000267 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 765962000268 active site 765962000269 interdomain interaction site; other site 765962000270 putative metal-binding site [ion binding]; other site 765962000271 nucleotide binding site [chemical binding]; other site 765962000272 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 765962000273 domain I; other site 765962000274 DNA binding groove [nucleotide binding] 765962000275 phosphate binding site [ion binding]; other site 765962000276 domain II; other site 765962000277 domain III; other site 765962000278 nucleotide binding site [chemical binding]; other site 765962000279 catalytic site [active] 765962000280 domain IV; other site 765962000281 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 765962000282 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 765962000283 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 765962000284 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 765962000285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962000286 FeS/SAM binding site; other site 765962000287 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 765962000288 phosphoenolpyruvate synthase; Validated; Region: PRK06464 765962000289 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765962000290 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 765962000291 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 765962000292 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 765962000293 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 765962000294 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 765962000295 active site 765962000296 dimer interface [polypeptide binding]; other site 765962000297 motif 1; other site 765962000298 motif 2; other site 765962000299 motif 3; other site 765962000300 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765962000301 anticodon binding site; other site 765962000302 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 765962000303 translation initiation factor IF-3; Region: infC; TIGR00168 765962000304 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 765962000305 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 765962000306 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 765962000307 23S rRNA binding site [nucleotide binding]; other site 765962000308 L21 binding site [polypeptide binding]; other site 765962000309 L13 binding site [polypeptide binding]; other site 765962000310 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000311 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 765962000312 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 765962000313 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 765962000314 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 765962000315 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 765962000316 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 765962000317 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 765962000318 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 765962000319 catalytic triad [active] 765962000320 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 765962000321 iron-sulfur cluster-binding protein; Region: TIGR00273 765962000322 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 765962000323 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 765962000324 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 765962000325 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765962000326 Cysteine-rich domain; Region: CCG; pfam02754 765962000327 Cysteine-rich domain; Region: CCG; pfam02754 765962000328 L-lactate permease; Region: Lactate_perm; cl00701 765962000329 glycolate transporter; Provisional; Region: PRK09695 765962000330 glycolate transporter; Provisional; Region: PRK09695 765962000331 L-lactate permease; Region: Lactate_perm; cl00701 765962000332 DNA glycosylase MutY; Provisional; Region: PRK13910 765962000333 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765962000334 minor groove reading motif; other site 765962000335 helix-hairpin-helix signature motif; other site 765962000336 substrate binding pocket [chemical binding]; other site 765962000337 active site 765962000338 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 765962000339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 765962000340 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962000341 transmembrane helices; other site 765962000342 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 765962000343 Low-spin heme binding site [chemical binding]; other site 765962000344 D-pathway; other site 765962000345 Putative water exit pathway; other site 765962000346 Binuclear center (active site) [active] 765962000347 K-pathway; other site 765962000348 Putative proton exit pathway; other site 765962000349 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 765962000350 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 765962000351 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 765962000352 Cytochrome c; Region: Cytochrom_C; cl11414 765962000353 Cytochrome c; Region: Cytochrom_C; cl11414 765962000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765962000355 recombinase A; Provisional; Region: recA; PRK09354 765962000356 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 765962000357 hexamer interface [polypeptide binding]; other site 765962000358 Walker A motif; other site 765962000359 ATP binding site [chemical binding]; other site 765962000360 Walker B motif; other site 765962000361 enolase; Provisional; Region: eno; PRK00077 765962000362 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 765962000363 dimer interface [polypeptide binding]; other site 765962000364 metal binding site [ion binding]; metal-binding site 765962000365 substrate binding pocket [chemical binding]; other site 765962000366 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 765962000367 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 765962000368 ADP binding site [chemical binding]; other site 765962000369 magnesium binding site [ion binding]; other site 765962000370 putative shikimate binding site; other site 765962000371 Cache domain; Region: Cache_1; pfam02743 765962000372 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 765962000373 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 765962000374 Ligand binding site [chemical binding]; other site 765962000375 metal binding site [ion binding]; metal-binding site 765962000376 Sel1 repeat; Region: Sel1; cl02723 765962000377 Sel1 repeat; Region: Sel1; cl02723 765962000378 Sel1 repeat; Region: Sel1; cl02723 765962000379 Sel1 repeat; Region: Sel1; cl02723 765962000380 Sel1 repeat; Region: Sel1; cl02723 765962000381 Domain of unknown function DUF28; Region: DUF28; cl00361 765962000382 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 765962000383 dimer interface [polypeptide binding]; other site 765962000384 active site 765962000385 Schiff base residues; other site 765962000386 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 765962000387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 765962000388 dimer interface [polypeptide binding]; other site 765962000389 phosphorylation site [posttranslational modification] 765962000390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765962000391 ATP binding site [chemical binding]; other site 765962000392 Mg2+ binding site [ion binding]; other site 765962000393 G-X-G motif; other site 765962000394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765962000395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962000396 active site 765962000397 phosphorylation site [posttranslational modification] 765962000398 intermolecular recognition site; other site 765962000399 dimerization interface [polypeptide binding]; other site 765962000400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 765962000401 DNA binding site [nucleotide binding] 765962000402 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 765962000403 Peptidase family U32; Region: Peptidase_U32; cl03113 765962000404 peptide chain release factor 2; Region: prfB; TIGR00020 765962000405 RF-1 domain; Region: RF-1; cl02875 765962000406 RF-1 domain; Region: RF-1; cl02875 765962000407 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 765962000408 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 765962000409 dimer interface [polypeptide binding]; other site 765962000410 putative functional site; other site 765962000411 putative MPT binding site; other site 765962000412 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 765962000413 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 765962000414 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 765962000415 PPIC-type PPIASE domain; Region: Rotamase; cl08278 765962000416 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 765962000417 hypothetical protein; Provisional; Region: PRK08185 765962000418 intersubunit interface [polypeptide binding]; other site 765962000419 active site 765962000420 zinc binding site [ion binding]; other site 765962000421 Na+ binding site [ion binding]; other site 765962000422 elongation factor P; Validated; Region: PRK00529 765962000423 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765962000424 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 765962000425 RNA binding site [nucleotide binding]; other site 765962000426 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 765962000427 RNA binding site [nucleotide binding]; other site 765962000428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000429 DNA binding site [nucleotide binding] 765962000430 substrate interaction site [chemical binding]; other site 765962000431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000432 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 765962000433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962000434 Walker A motif; other site 765962000435 ATP binding site [chemical binding]; other site 765962000436 Walker B motif; other site 765962000437 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 765962000438 pseudaminic acid synthase; Region: PseI; TIGR03586 765962000439 NeuB family; Region: NeuB; cl00496 765962000440 SAF domain; Region: SAF; cl00555 765962000441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765962000442 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765962000443 Walker A/P-loop; other site 765962000444 ATP binding site [chemical binding]; other site 765962000445 Q-loop/lid; other site 765962000446 ABC transporter signature motif; other site 765962000447 Walker B; other site 765962000448 D-loop; other site 765962000449 H-loop/switch region; other site 765962000450 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 765962000451 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 765962000452 active site 765962000453 catalytic triad [active] 765962000454 Colicin V production protein; Region: Colicin_V; cl00567 765962000455 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 765962000456 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 765962000457 dimer interface [polypeptide binding]; other site 765962000458 putative anticodon binding site; other site 765962000459 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 765962000460 motif 1; other site 765962000461 active site 765962000462 motif 2; other site 765962000463 motif 3; other site 765962000464 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 765962000465 dimer interface [polypeptide binding]; other site 765962000466 glycine-pyridoxal phosphate binding site [chemical binding]; other site 765962000467 active site 765962000468 folate binding site [chemical binding]; other site 765962000469 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 765962000470 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 765962000471 Protein of unknown function DUF262; Region: DUF262; cl14890 765962000472 Protein of unknown function DUF262; Region: DUF262; cl14890 765962000473 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 765962000474 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 765962000475 putative active site [active] 765962000476 catalytic site [active] 765962000477 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 765962000478 putative active site [active] 765962000479 catalytic site [active] 765962000480 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 765962000481 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 765962000482 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 765962000483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 765962000484 domain; Region: Succ_DH_flav_C; pfam02910 765962000485 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 765962000486 Iron-sulfur protein interface; other site 765962000487 proximal heme binding site [chemical binding]; other site 765962000488 distal heme binding site [chemical binding]; other site 765962000489 dimer interface [polypeptide binding]; other site 765962000490 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 765962000491 substrate binding site [chemical binding]; other site 765962000492 dimer interface [polypeptide binding]; other site 765962000493 catalytic triad [active] 765962000494 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 765962000495 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 765962000496 NAD binding site [chemical binding]; other site 765962000497 homotetramer interface [polypeptide binding]; other site 765962000498 homodimer interface [polypeptide binding]; other site 765962000499 substrate binding site [chemical binding]; other site 765962000500 active site 765962000501 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 765962000502 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 765962000503 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 765962000504 trimer interface [polypeptide binding]; other site 765962000505 active site 765962000506 UDP-GlcNAc binding site [chemical binding]; other site 765962000507 lipid binding site [chemical binding]; lipid-binding site 765962000508 S-adenosylmethionine synthetase; Validated; Region: PRK05250 765962000509 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 765962000510 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 765962000511 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 765962000512 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765962000513 active site 765962000514 multimer interface [polypeptide binding]; other site 765962000515 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 765962000516 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 765962000517 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 765962000518 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 765962000519 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 765962000520 dimer interface [polypeptide binding]; other site 765962000521 active site 765962000522 CoA binding pocket [chemical binding]; other site 765962000523 antiporter inner membrane protein; Provisional; Region: PRK11670 765962000524 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765962000525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765962000526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765962000527 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962000528 heat shock protein 90; Provisional; Region: PRK05218 765962000529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765962000530 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765962000531 Sel1 repeat; Region: Sel1; cl02723 765962000532 Sel1 repeat; Region: Sel1; cl02723 765962000533 Sel1 repeat; Region: Sel1; cl02723 765962000534 Sel1 repeat; Region: Sel1; cl02723 765962000535 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 765962000536 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 765962000537 metal binding site [ion binding]; metal-binding site 765962000538 dimer interface [polypeptide binding]; other site 765962000539 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 765962000540 glucose-inhibited division protein A; Region: gidA; TIGR00136 765962000541 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 765962000542 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 765962000543 transmembrane helices; other site 765962000544 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 765962000545 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 765962000546 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 765962000547 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 765962000548 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 765962000549 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 765962000550 substrate binding site [chemical binding]; other site 765962000551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962000552 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765962000553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765962000554 catalytic residue [active] 765962000555 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 765962000556 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 765962000557 trimerization site [polypeptide binding]; other site 765962000558 active site 765962000559 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 765962000560 NifU-like domain; Region: NifU; cl00484 765962000561 DNA repair protein RadA; Region: sms; TIGR00416 765962000562 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 765962000563 Walker A motif/ATP binding site; other site 765962000564 ATP binding site [chemical binding]; other site 765962000565 Walker B motif; other site 765962000566 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 765962000567 SelR domain; Region: SelR; cl00369 765962000568 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 765962000569 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000570 high affinity sulphate transporter 1; Region: sulP; TIGR00815 765962000571 Sulfate transporter family; Region: Sulfate_transp; cl00967 765962000572 potential protein location (hypothetical protein HPSJM_01265 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-N) 765962000573 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000574 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 765962000575 Ligand binding site [chemical binding]; other site 765962000576 oligomer interface [polypeptide binding]; other site 765962000577 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 765962000578 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765962000579 hypothetical protein; Provisional; Region: PRK04081 765962000580 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 765962000581 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765962000582 Sel1 repeat; Region: Sel1; cl02723 765962000583 Sel1 repeat; Region: Sel1; cl02723 765962000584 Sel1 repeat; Region: Sel1; cl02723 765962000585 Sel1 repeat; Region: Sel1; cl02723 765962000586 Cytochrome c; Region: Cytochrom_C; cl11414 765962000587 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 765962000588 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 765962000589 domain interfaces; other site 765962000590 active site 765962000591 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 765962000592 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 765962000593 dimer interface [polypeptide binding]; other site 765962000594 motif 1; other site 765962000595 active site 765962000596 motif 2; other site 765962000597 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 765962000598 putative deacylase active site [active] 765962000599 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765962000600 active site 765962000601 motif 3; other site 765962000602 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 765962000603 anticodon binding site; other site 765962000604 glutamyl-tRNA reductase; Region: hemA; TIGR01035 765962000605 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 765962000606 tRNA; other site 765962000607 putative tRNA binding site [nucleotide binding]; other site 765962000608 putative NADP binding site [chemical binding]; other site 765962000609 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 765962000610 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 765962000611 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765962000612 substrate binding pocket [chemical binding]; other site 765962000613 chain length determination region; other site 765962000614 substrate-Mg2+ binding site; other site 765962000615 catalytic residues [active] 765962000616 aspartate-rich region 1; other site 765962000617 active site lid residues [active] 765962000618 aspartate-rich region 2; other site 765962000619 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 765962000620 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765962000621 Ferritin-like domain; Region: Ferritin; pfam00210 765962000622 dimerization interface [polypeptide binding]; other site 765962000623 DPS ferroxidase diiron center [ion binding]; other site 765962000624 ion pore; other site 765962000625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 765962000626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 765962000627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765962000628 ATP binding site [chemical binding]; other site 765962000629 Mg2+ binding site [ion binding]; other site 765962000630 G-X-G motif; other site 765962000631 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 765962000632 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 765962000633 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 765962000634 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 765962000635 ATP binding site [chemical binding]; other site 765962000636 Mg++ binding site [ion binding]; other site 765962000637 motif III; other site 765962000638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962000639 nucleotide binding region [chemical binding]; other site 765962000640 ATP-binding site [chemical binding]; other site 765962000641 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 765962000642 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 765962000643 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 765962000644 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765962000645 Walker A/P-loop; other site 765962000646 ATP binding site [chemical binding]; other site 765962000647 Q-loop/lid; other site 765962000648 ABC transporter signature motif; other site 765962000649 Walker B; other site 765962000650 D-loop; other site 765962000651 H-loop/switch region; other site 765962000652 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765962000653 Walker A/P-loop; other site 765962000654 ATP binding site [chemical binding]; other site 765962000655 Q-loop/lid; other site 765962000656 ABC transporter signature motif; other site 765962000657 Walker B; other site 765962000658 D-loop; other site 765962000659 H-loop/switch region; other site 765962000660 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765962000661 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 765962000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962000663 dimer interface [polypeptide binding]; other site 765962000664 conserved gate region; other site 765962000665 putative PBP binding loops; other site 765962000666 ABC-ATPase subunit interface; other site 765962000667 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000668 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000669 adenylosuccinate synthetase; Provisional; Region: PRK01117 765962000670 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 765962000671 GDP-binding site [chemical binding]; other site 765962000672 ACT binding site; other site 765962000673 IMP binding site; other site 765962000674 MgtE intracellular N domain; Region: MgtE_N; cl15244 765962000675 RIP metalloprotease RseP; Region: TIGR00054 765962000676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 765962000677 active site 765962000678 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 765962000679 protein binding site [polypeptide binding]; other site 765962000680 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 765962000681 putative substrate binding region [chemical binding]; other site 765962000682 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 765962000683 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 765962000684 generic binding surface II; other site 765962000685 generic binding surface I; other site 765962000686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000687 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 765962000688 Clp amino terminal domain; Region: Clp_N; pfam02861 765962000689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000690 Walker A motif; other site 765962000691 ATP binding site [chemical binding]; other site 765962000692 Walker B motif; other site 765962000693 arginine finger; other site 765962000694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000695 Walker A motif; other site 765962000696 ATP binding site [chemical binding]; other site 765962000697 Walker B motif; other site 765962000698 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765962000699 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 765962000700 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 765962000701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 765962000702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 765962000703 active site 765962000704 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 765962000705 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 765962000706 active site 765962000707 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765962000708 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 765962000709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962000710 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 765962000711 putative acyl-acceptor binding pocket; other site 765962000712 Flagellin N-methylase; Region: FliB; cl00497 765962000713 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 765962000714 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 765962000715 hypothetical protein; Provisional; Region: PRK13795 765962000716 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 765962000717 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 765962000718 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765962000719 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 765962000720 putative active site [active] 765962000721 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 765962000722 putative acyl-acceptor binding pocket; other site 765962000723 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 765962000724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 765962000725 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962000726 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 765962000727 active site 765962000728 dimer interface [polypeptide binding]; other site 765962000729 metal binding site [ion binding]; metal-binding site 765962000730 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 765962000731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765962000732 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 765962000733 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765962000734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962000735 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 765962000736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000737 Walker B motif; other site 765962000738 arginine finger; other site 765962000739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765962000740 Vacuolating cyotoxin; Region: VacA; pfam02691 765962000741 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962000742 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962000743 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 765962000744 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962000745 Autotransporter beta-domain; Region: Autotransporter; cl02365 765962000746 diaminopimelate decarboxylase; Region: lysA; TIGR01048 765962000747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 765962000748 active site 765962000749 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765962000750 substrate binding site [chemical binding]; other site 765962000751 catalytic residues [active] 765962000752 dimer interface [polypeptide binding]; other site 765962000753 Chorismate mutase type II; Region: CM_2; cl00693 765962000754 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765962000755 chorismate binding enzyme; Region: Chorismate_bind; cl10555 765962000756 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 765962000757 Aminotransferase class IV; Region: Aminotran_4; pfam01063 765962000758 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 765962000759 Predicted amidohydrolase [General function prediction only]; Region: COG0388 765962000760 multimer interface [polypeptide binding]; other site 765962000761 active site 765962000762 catalytic triad [active] 765962000763 dimer interface [polypeptide binding]; other site 765962000764 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 765962000765 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 765962000766 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 765962000767 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 765962000768 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 765962000769 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765962000770 peptide binding site [polypeptide binding]; other site 765962000771 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765962000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962000773 dimer interface [polypeptide binding]; other site 765962000774 conserved gate region; other site 765962000775 putative PBP binding loops; other site 765962000776 ABC-ATPase subunit interface; other site 765962000777 dipeptide transporter; Provisional; Region: PRK10913 765962000778 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 765962000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962000780 dimer interface [polypeptide binding]; other site 765962000781 conserved gate region; other site 765962000782 putative PBP binding loops; other site 765962000783 ABC-ATPase subunit interface; other site 765962000784 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765962000785 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 765962000786 Walker A/P-loop; other site 765962000787 ATP binding site [chemical binding]; other site 765962000788 Q-loop/lid; other site 765962000789 ABC transporter signature motif; other site 765962000790 Walker B; other site 765962000791 D-loop; other site 765962000792 H-loop/switch region; other site 765962000793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765962000794 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 765962000795 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765962000796 Walker A/P-loop; other site 765962000797 ATP binding site [chemical binding]; other site 765962000798 Q-loop/lid; other site 765962000799 ABC transporter signature motif; other site 765962000800 Walker B; other site 765962000801 D-loop; other site 765962000802 H-loop/switch region; other site 765962000803 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765962000804 GTPase CgtA; Reviewed; Region: obgE; PRK12299 765962000805 GTP1/OBG; Region: GTP1_OBG; pfam01018 765962000806 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 765962000807 G1 box; other site 765962000808 GTP/Mg2+ binding site [chemical binding]; other site 765962000809 Switch I region; other site 765962000810 G2 box; other site 765962000811 G3 box; other site 765962000812 Switch II region; other site 765962000813 G4 box; other site 765962000814 G5 box; other site 765962000815 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 765962000816 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 765962000817 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 765962000818 inhibitor-cofactor binding pocket; inhibition site 765962000819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962000820 catalytic residue [active] 765962000821 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 765962000822 Predicted amidohydrolase [General function prediction only]; Region: COG0388 765962000823 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 765962000824 active site 765962000825 catalytic triad [active] 765962000826 dimer interface [polypeptide binding]; other site 765962000827 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 765962000828 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 765962000829 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 765962000830 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962000831 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 765962000832 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 765962000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765962000834 putative substrate translocation pore; other site 765962000835 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000836 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 765962000837 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 765962000838 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 765962000839 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 765962000840 arginyl-tRNA synthetase; Region: argS; TIGR00456 765962000841 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 765962000842 active site 765962000843 HIGH motif; other site 765962000844 KMSK motif region; other site 765962000845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765962000846 tRNA binding surface [nucleotide binding]; other site 765962000847 anticodon binding site; other site 765962000848 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 765962000849 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 765962000850 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 765962000851 catalytic site [active] 765962000852 G-X2-G-X-G-K; other site 765962000853 nuclease NucT; Provisional; Region: PRK13912 765962000854 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 765962000855 putative active site [active] 765962000856 catalytic site [active] 765962000857 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962000858 Flagellar L-ring protein; Region: FlgH; cl00905 765962000859 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 765962000860 ligand binding site [chemical binding]; other site 765962000861 tetramer interface [polypeptide binding]; other site 765962000862 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 765962000863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765962000864 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765962000865 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 765962000866 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 765962000867 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 765962000868 NAD synthase; Region: NAD_synthase; pfam02540 765962000869 homodimer interface [polypeptide binding]; other site 765962000870 NAD binding pocket [chemical binding]; other site 765962000871 ATP binding pocket [chemical binding]; other site 765962000872 Mg binding site [ion binding]; other site 765962000873 active-site loop [active] 765962000874 ketol-acid reductoisomerase; Provisional; Region: PRK05479 765962000875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962000876 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 765962000877 septum site-determining protein MinD; Region: minD_bact; TIGR01968 765962000878 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 765962000879 Switch I; other site 765962000880 Switch II; other site 765962000881 Septum formation topological specificity factor MinE; Region: MinE; cl00538 765962000882 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 765962000883 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 765962000884 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765962000885 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765962000886 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 765962000887 active site 765962000888 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 765962000889 DHH family; Region: DHH; pfam01368 765962000890 DHHA1 domain; Region: DHHA1; pfam02272 765962000891 CTP synthetase; Validated; Region: pyrG; PRK05380 765962000892 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 765962000893 Catalytic site [active] 765962000894 Active site [active] 765962000895 UTP binding site [chemical binding]; other site 765962000896 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 765962000897 active site 765962000898 putative oxyanion hole; other site 765962000899 catalytic triad [active] 765962000900 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 765962000901 active site 765962000902 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 765962000903 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 765962000904 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 765962000905 flagellar motor switch protein FliG; Region: fliG; TIGR00207 765962000906 FliG C-terminal domain; Region: FliG_C; pfam01706 765962000907 flagellar assembly protein H; Validated; Region: fliH; PRK06669 765962000908 Flagellar assembly protein FliH; Region: FliH; pfam02108 765962000909 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 765962000910 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 765962000911 TPP-binding site; other site 765962000912 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765962000913 PYR/PP interface [polypeptide binding]; other site 765962000914 dimer interface [polypeptide binding]; other site 765962000915 TPP binding site [chemical binding]; other site 765962000916 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765962000917 GTP-binding protein LepA; Provisional; Region: PRK05433 765962000918 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 765962000919 G1 box; other site 765962000920 putative GEF interaction site [polypeptide binding]; other site 765962000921 GTP/Mg2+ binding site [chemical binding]; other site 765962000922 Switch I region; other site 765962000923 G2 box; other site 765962000924 G3 box; other site 765962000925 Switch II region; other site 765962000926 G4 box; other site 765962000927 G5 box; other site 765962000928 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 765962000929 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 765962000930 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 765962000931 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 765962000932 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 765962000933 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 765962000934 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 765962000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765962000936 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 765962000937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962000938 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 765962000939 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 765962000940 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 765962000941 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 765962000942 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 765962000943 TPP-binding site [chemical binding]; other site 765962000944 dimer interface [polypeptide binding]; other site 765962000945 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765962000946 PYR/PP interface [polypeptide binding]; other site 765962000947 dimer interface [polypeptide binding]; other site 765962000948 TPP binding site [chemical binding]; other site 765962000949 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765962000950 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 765962000951 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 765962000952 active site 765962000953 Riboflavin kinase; Region: Flavokinase; pfam01687 765962000954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765962000955 hemolysin TlyA family protein; Region: tly; TIGR00478 765962000956 RNA binding surface [nucleotide binding]; other site 765962000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962000958 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 765962000959 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 765962000960 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 765962000961 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962000962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765962000963 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 765962000964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962000965 Walker A/P-loop; other site 765962000966 ATP binding site [chemical binding]; other site 765962000967 Q-loop/lid; other site 765962000968 ABC transporter signature motif; other site 765962000969 Walker B; other site 765962000970 D-loop; other site 765962000971 H-loop/switch region; other site 765962000972 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 765962000973 Restriction endonuclease; Region: Mrr_cat; cl00747 765962000974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962000975 High-affinity nickel-transport protein; Region: NicO; cl00964 765962000976 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cd00596 765962000977 active site 765962000978 Zn-binding site [ion binding]; other site 765962000979 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 765962000980 metal-binding site [ion binding] 765962000981 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 765962000982 metal-binding site [ion binding] 765962000983 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 765962000984 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765962000985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962000986 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 765962000987 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765962000988 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 765962000989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962000990 Walker A motif; other site 765962000991 ATP binding site [chemical binding]; other site 765962000992 Walker B motif; other site 765962000993 arginine finger; other site 765962000994 Peptidase family M41; Region: Peptidase_M41; pfam01434 765962000995 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 765962000996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962000997 S-adenosylmethionine binding site [chemical binding]; other site 765962000998 Response regulator receiver domain; Region: Response_reg; pfam00072 765962000999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962001000 active site 765962001001 phosphorylation site [posttranslational modification] 765962001002 intermolecular recognition site; other site 765962001003 dimerization interface [polypeptide binding]; other site 765962001004 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001005 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 765962001006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962001007 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 765962001008 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 765962001009 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 765962001010 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 765962001011 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 765962001012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962001013 Walker A motif; other site 765962001014 ATP binding site [chemical binding]; other site 765962001015 Walker B motif; other site 765962001016 arginine finger; other site 765962001017 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 765962001018 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 765962001019 oligomerization interface [polypeptide binding]; other site 765962001020 active site 765962001021 metal binding site [ion binding]; metal-binding site 765962001022 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001023 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001024 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765962001025 septum formation inhibitor; Reviewed; Region: minC; PRK00556 765962001026 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 765962001027 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 765962001028 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 765962001029 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 765962001030 homoserine kinase; Region: thrB; TIGR00191 765962001031 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 765962001032 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 765962001033 translation initiation factor IF-2; Region: IF-2; TIGR00487 765962001034 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765962001035 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 765962001036 G1 box; other site 765962001037 putative GEF interaction site [polypeptide binding]; other site 765962001038 GTP/Mg2+ binding site [chemical binding]; other site 765962001039 Switch I region; other site 765962001040 G2 box; other site 765962001041 G3 box; other site 765962001042 Switch II region; other site 765962001043 G4 box; other site 765962001044 G5 box; other site 765962001045 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 765962001046 Translation-initiation factor 2; Region: IF-2; pfam11987 765962001047 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 765962001048 Ribosome-binding factor A; Region: RBFA; cl00542 765962001049 Uncharacterised BCR, YhbC family COG0779; Region: DUF150; pfam02576 765962001050 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 765962001051 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 765962001052 Sm1 motif; other site 765962001053 D3 - B interaction site; other site 765962001054 D1 - D2 interaction site; other site 765962001055 Hfq - Hfq interaction site; other site 765962001056 RNA binding pocket [nucleotide binding]; other site 765962001057 Sm2 motif; other site 765962001058 acetyl-CoA synthetase; Provisional; Region: PRK00174 765962001059 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 765962001060 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 765962001061 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 765962001062 putative active site [active] 765962001063 putative metal binding site [ion binding]; other site 765962001064 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765962001065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765962001066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962001067 active site 765962001068 intermolecular recognition site; other site 765962001069 dimerization interface [polypeptide binding]; other site 765962001070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 765962001071 DNA binding site [nucleotide binding] 765962001072 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 765962001073 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 765962001074 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 765962001075 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 765962001076 16S/18S rRNA binding site [nucleotide binding]; other site 765962001077 S13e-L30e interaction site [polypeptide binding]; other site 765962001078 25S rRNA binding site [nucleotide binding]; other site 765962001079 O-Antigen ligase; Region: Wzy_C; cl04850 765962001080 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 765962001081 trimer interface [polypeptide binding]; other site 765962001082 active site 765962001083 dimer interface [polypeptide binding]; other site 765962001084 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765962001085 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 765962001086 active site 765962001087 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 765962001088 catalytic center binding site [active] 765962001089 ATP binding site [chemical binding]; other site 765962001090 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 765962001091 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962001092 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 765962001093 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 765962001094 P-loop; other site 765962001095 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 765962001096 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 765962001097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765962001098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 765962001099 DNA binding residues [nucleotide binding] 765962001100 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 765962001101 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765962001102 flagellar motor switch protein FliY; Validated; Region: PRK08432 765962001103 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765962001104 Domain of unknown function (DUF386); Region: DUF386; cl01047 765962001105 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 765962001106 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 765962001107 metal binding site 2 [ion binding]; metal-binding site 765962001108 putative DNA binding helix; other site 765962001109 metal binding site 1 [ion binding]; metal-binding site 765962001110 dimer interface [polypeptide binding]; other site 765962001111 structural Zn2+ binding site [ion binding]; other site 765962001112 recombination factor protein RarA; Reviewed; Region: PRK13342 765962001113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962001114 Walker A motif; other site 765962001115 ATP binding site [chemical binding]; other site 765962001116 Walker B motif; other site 765962001117 arginine finger; other site 765962001118 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 765962001119 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 765962001120 DNA binding residues [nucleotide binding] 765962001121 putative dimer interface [polypeptide binding]; other site 765962001122 chaperone protein DnaJ; Provisional; Region: PRK14299 765962001123 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 765962001124 HSP70 interaction site [polypeptide binding]; other site 765962001125 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 765962001126 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 765962001127 5'-3' exonuclease; Provisional; Region: PRK14976 765962001128 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 765962001129 putative active site [active] 765962001130 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 765962001131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 765962001132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962001133 active site 765962001134 phosphorylation site [posttranslational modification] 765962001135 intermolecular recognition site; other site 765962001136 dimerization interface [polypeptide binding]; other site 765962001137 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 765962001138 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 765962001139 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 765962001140 substrate binding site [chemical binding]; other site 765962001141 dimer interface [polypeptide binding]; other site 765962001142 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 765962001143 homotrimer interaction site [polypeptide binding]; other site 765962001144 zinc binding site [ion binding]; other site 765962001145 CDP-binding sites; other site 765962001146 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 765962001147 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 765962001148 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 765962001149 protein binding site [polypeptide binding]; other site 765962001150 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 765962001151 protein binding site [polypeptide binding]; other site 765962001152 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 765962001153 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765962001154 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 765962001155 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 765962001156 putative NAD(P) binding site [chemical binding]; other site 765962001157 active site 765962001158 dihydrodipicolinate synthase; Region: dapA; TIGR00674 765962001159 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 765962001160 dimer interface [polypeptide binding]; other site 765962001161 active site 765962001162 catalytic residue [active] 765962001163 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 765962001164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765962001165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765962001166 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 765962001167 quinone interaction residues [chemical binding]; other site 765962001168 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 765962001169 active site 765962001170 catalytic residues [active] 765962001171 FMN binding site [chemical binding]; other site 765962001172 substrate binding site [chemical binding]; other site 765962001173 Polyphosphate kinase; Region: PP_kinase; pfam02503 765962001174 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 765962001175 putative domain interface [polypeptide binding]; other site 765962001176 putative active site [active] 765962001177 catalytic site [active] 765962001178 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 765962001179 putative active site [active] 765962001180 putative domain interface [polypeptide binding]; other site 765962001181 catalytic site [active] 765962001182 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962001183 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 765962001184 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962001185 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 765962001186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962001187 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 765962001188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962001189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962001190 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 765962001191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 765962001192 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 765962001193 putative metal binding site [ion binding]; other site 765962001194 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 765962001195 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 765962001196 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 765962001197 active site 765962001198 Zn binding site [ion binding]; other site 765962001199 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765962001200 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765962001201 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765962001203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962001204 dimer interface [polypeptide binding]; other site 765962001205 conserved gate region; other site 765962001206 putative PBP binding loops; other site 765962001207 ABC-ATPase subunit interface; other site 765962001208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001209 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 765962001210 Walker A/P-loop; other site 765962001211 ATP binding site [chemical binding]; other site 765962001212 Q-loop/lid; other site 765962001213 ABC transporter signature motif; other site 765962001214 Walker B; other site 765962001215 D-loop; other site 765962001216 H-loop/switch region; other site 765962001217 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 765962001218 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765962001219 active site 765962001220 HIGH motif; other site 765962001221 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765962001222 active site 765962001223 KMSKS motif; other site 765962001224 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962001226 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 765962001227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765962001228 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 765962001229 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 765962001230 G1 box; other site 765962001231 putative GEF interaction site [polypeptide binding]; other site 765962001232 GTP/Mg2+ binding site [chemical binding]; other site 765962001233 Switch I region; other site 765962001234 G2 box; other site 765962001235 G3 box; other site 765962001236 Switch II region; other site 765962001237 G4 box; other site 765962001238 G5 box; other site 765962001239 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 765962001240 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 765962001241 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 765962001242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962001243 cofactor binding site; other site 765962001244 DNA binding site [nucleotide binding] 765962001245 substrate interaction site [chemical binding]; other site 765962001246 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 765962001247 putative heme binding pocket [chemical binding]; other site 765962001248 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962001249 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962001250 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 765962001251 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 765962001252 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 765962001253 Cation transport protein; Region: TrkH; cl10514 765962001254 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 765962001255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962001256 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962001257 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 765962001258 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 765962001259 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 765962001260 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 765962001261 Mg++ binding site [ion binding]; other site 765962001262 putative catalytic motif [active] 765962001263 putative substrate binding site [chemical binding]; other site 765962001264 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 765962001265 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765962001266 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765962001267 Protein of unknown function (DUF493); Region: DUF493; cl01102 765962001268 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 765962001269 active site 765962001270 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 765962001271 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 765962001272 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541 765962001273 dimerization interface [polypeptide binding]; other site 765962001274 substrate binding site [chemical binding]; other site 765962001275 active site 765962001276 calcium binding site [ion binding]; other site 765962001277 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 765962001278 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 765962001279 putative DNA binding surface [nucleotide binding]; other site 765962001280 dimer interface [polypeptide binding]; other site 765962001281 beta-clamp/translesion DNA polymerase binding surface; other site 765962001282 beta-clamp/clamp loader binding surface; other site 765962001283 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 765962001284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765962001285 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 765962001286 anchoring element; other site 765962001287 dimer interface [polypeptide binding]; other site 765962001288 ATP binding site [chemical binding]; other site 765962001289 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 765962001290 active site 765962001291 putative metal-binding site [ion binding]; other site 765962001292 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765962001293 R.Pab1 restriction endonuclease; Region: RE_R_Pab1; pfam09522 765962001294 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765962001295 Peptidase family M23; Region: Peptidase_M23; pfam01551 765962001296 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 765962001297 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 765962001298 dimer interface [polypeptide binding]; other site 765962001299 ADP-ribose binding site [chemical binding]; other site 765962001300 active site 765962001301 nudix motif; other site 765962001302 metal binding site [ion binding]; metal-binding site 765962001303 FAD binding domain; Region: FAD_binding_4; pfam01565 765962001304 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 765962001305 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 765962001306 dihydrodipicolinate reductase; Region: dapB; TIGR00036 765962001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962001308 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 765962001309 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 765962001310 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 765962001311 prolyl-tRNA synthetase; Provisional; Region: PRK08661 765962001312 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 765962001313 VirB8 protein; Region: VirB8; cl01500 765962001314 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 765962001315 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 765962001316 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 765962001317 VirB7 interaction site; other site 765962001318 MAEBL; Provisional; Region: PTZ00121 765962001319 DC-EC Repeat; Region: CagY_M; pfam07337 765962001320 DC-EC Repeat; Region: CagY_M; pfam07337 765962001321 DC-EC Repeat; Region: CagY_M; pfam07337 765962001322 DC-EC Repeat; Region: CagY_M; pfam07337 765962001323 DC-EC Repeat; Region: CagY_M; pfam07337 765962001324 DC-EC Repeat; Region: CagY_M; pfam07337 765962001325 DC-EC Repeat; Region: CagY_M; pfam07337 765962001326 DC-EC Repeat; Region: CagY_M; pfam07337 765962001327 DC-EC Repeat; Region: CagY_M; pfam07337 765962001328 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 765962001329 CagZ; Region: CagZ; pfam09053 765962001330 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 765962001331 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 765962001332 ATP binding site [chemical binding]; other site 765962001333 Walker A motif; other site 765962001334 hexamer interface [polypeptide binding]; other site 765962001335 Walker B motif; other site 765962001336 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 765962001337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001338 Walker A motif; other site 765962001339 ATP binding site [chemical binding]; other site 765962001340 Walker B motif; other site 765962001341 DNA topoisomerase I; Validated; Region: PRK05582 765962001342 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765962001343 glutamine synthetase, type I; Region: GlnA; TIGR00653 765962001344 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 765962001345 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 765962001346 ribosomal protein L9; Region: L9; TIGR00158 765962001347 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 765962001348 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 765962001349 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 765962001350 active site 765962001351 HslU subunit interaction site [polypeptide binding]; other site 765962001352 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 765962001353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001355 GTPase Era; Reviewed; Region: era; PRK00089 765962001356 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 765962001357 G1 box; other site 765962001358 GTP/Mg2+ binding site [chemical binding]; other site 765962001359 Switch I region; other site 765962001360 G2 box; other site 765962001361 Switch II region; other site 765962001362 G3 box; other site 765962001363 G4 box; other site 765962001364 G5 box; other site 765962001365 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 765962001366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 765962001367 potential frameshift: common BLAST hit: gi|256829078|ref|YP_003157806.1| AAA ATPase 765962001368 DNA helicase, putative; Region: TIGR00376 765962001369 CagA exotoxin; Region: CagA; pfam03507 765962001370 DNA helicase, putative; Region: TIGR00376 765962001371 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 765962001372 transcription termination factor Rho; Provisional; Region: rho; PRK09376 765962001373 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 765962001374 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 765962001375 RNA binding site [nucleotide binding]; other site 765962001376 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 765962001377 multimer interface [polypeptide binding]; other site 765962001378 Walker A motif; other site 765962001379 ATP binding site [chemical binding]; other site 765962001380 Walker B motif; other site 765962001381 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 765962001382 Predicted methyltransferases [General function prediction only]; Region: COG0313 765962001383 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 765962001384 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 765962001385 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 765962001386 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 765962001387 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 765962001388 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 765962001389 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 765962001390 dimer interface [polypeptide binding]; other site 765962001391 active site 765962001392 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765962001393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 765962001394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962001395 NAD(P) binding site [chemical binding]; other site 765962001396 active site 765962001397 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 765962001398 Protein of unknown function, DUF417; Region: DUF417; cl01162 765962001399 diaminopimelate epimerase; Region: DapF; TIGR00652 765962001400 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765962001401 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765962001402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 765962001403 Domain of unknown function DUF20; Region: UPF0118; cl00465 765962001404 GTP-binding protein YchF; Reviewed; Region: PRK09601 765962001405 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 765962001406 G1 box; other site 765962001407 GTP/Mg2+ binding site [chemical binding]; other site 765962001408 Switch I region; other site 765962001409 G2 box; other site 765962001410 Switch II region; other site 765962001411 G3 box; other site 765962001412 G4 box; other site 765962001413 G5 box; other site 765962001414 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 765962001415 multifunctional aminopeptidase A; Provisional; Region: PRK00913 765962001416 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 765962001417 interface (dimer of trimers) [polypeptide binding]; other site 765962001418 Substrate-binding/catalytic site; other site 765962001419 Zn-binding sites [ion binding]; other site 765962001420 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 765962001421 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 765962001422 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 765962001423 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 765962001424 active site 765962001425 putative substrate binding region [chemical binding]; other site 765962001426 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765962001427 signal peptidase I; Provisional; Region: PRK10861 765962001428 Catalytic site [active] 765962001429 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765962001430 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 765962001431 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 765962001432 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 765962001433 homodimer interface [polypeptide binding]; other site 765962001434 NADP binding site [chemical binding]; other site 765962001435 substrate binding site [chemical binding]; other site 765962001436 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 765962001437 Sulfatase; Region: Sulfatase; cl10460 765962001438 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 765962001439 dihydroorotase, homodimeric type; Region: pyrC_dimer; TIGR00856 765962001440 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 765962001441 active site 765962001442 substrate binding pocket [chemical binding]; other site 765962001443 dimer interface [polypeptide binding]; other site 765962001444 Gram-negative bacterial tonB protein; Region: TonB; cl10048 765962001445 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765962001446 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 765962001447 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765962001448 minor groove reading motif; other site 765962001449 helix-hairpin-helix signature motif; other site 765962001450 substrate binding pocket [chemical binding]; other site 765962001451 active site 765962001452 FES domain; Region: FES; smart00525 765962001453 FeoA domain; Region: FeoA; cl00838 765962001454 YceG-like family; Region: YceG; pfam02618 765962001455 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 765962001456 dimerization interface [polypeptide binding]; other site 765962001457 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 765962001458 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 765962001459 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 765962001460 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 765962001461 dimer interface [polypeptide binding]; other site 765962001462 PYR/PP interface [polypeptide binding]; other site 765962001463 TPP binding site [chemical binding]; other site 765962001464 substrate binding site [chemical binding]; other site 765962001465 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 765962001466 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 765962001467 TPP-binding site [chemical binding]; other site 765962001468 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 765962001469 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 765962001470 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 765962001471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962001472 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 765962001473 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 765962001474 Transglycosylase; Region: Transgly; cl07896 765962001475 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 765962001476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 765962001477 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 765962001478 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962001479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765962001480 catalytic residue [active] 765962001481 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 765962001482 diguanylate cyclase; Provisional; Region: PRK09894 765962001483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765962001484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001485 Walker A/P-loop; other site 765962001486 ATP binding site [chemical binding]; other site 765962001487 Q-loop/lid; other site 765962001488 ABC transporter signature motif; other site 765962001489 Walker B; other site 765962001490 D-loop; other site 765962001491 H-loop/switch region; other site 765962001492 flagellin A; Reviewed; Region: PRK12584 765962001493 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 765962001494 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 765962001495 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 765962001496 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 765962001497 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765962001498 minor groove reading motif; other site 765962001499 helix-hairpin-helix signature motif; other site 765962001500 active site 765962001501 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 765962001502 substrate binding site [chemical binding]; other site 765962001503 active site 765962001504 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765962001505 Outer membrane efflux protein; Region: OEP; pfam02321 765962001506 Outer membrane efflux protein; Region: OEP; pfam02321 765962001507 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765962001508 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 765962001509 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001510 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962001511 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 765962001512 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962001513 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962001514 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962001515 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 765962001516 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962001517 Autotransporter beta-domain; Region: Autotransporter; cl02365 765962001518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001519 ABC transporter signature motif; other site 765962001520 Walker B; other site 765962001521 D-loop; other site 765962001522 H-loop/switch region; other site 765962001523 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 765962001524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001525 Walker A/P-loop; other site 765962001526 ATP binding site [chemical binding]; other site 765962001527 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 765962001528 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 765962001529 nucleotide binding pocket [chemical binding]; other site 765962001530 K-X-D-G motif; other site 765962001531 catalytic site [active] 765962001532 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 765962001533 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 765962001534 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 765962001535 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 765962001536 Dimer interface [polypeptide binding]; other site 765962001537 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 765962001538 Response regulator receiver domain; Region: Response_reg; pfam00072 765962001539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962001540 active site 765962001541 phosphorylation site [posttranslational modification] 765962001542 intermolecular recognition site; other site 765962001543 dimerization interface [polypeptide binding]; other site 765962001544 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 765962001545 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 765962001546 dimer interface [polypeptide binding]; other site 765962001547 anticodon binding site; other site 765962001548 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 765962001549 homodimer interface [polypeptide binding]; other site 765962001550 motif 1; other site 765962001551 active site 765962001552 motif 2; other site 765962001553 GAD domain; Region: GAD; pfam02938 765962001554 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765962001555 active site 765962001556 motif 3; other site 765962001557 adenylate kinase; Reviewed; Region: adk; PRK00279 765962001558 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 765962001559 AMP-binding site [chemical binding]; other site 765962001560 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 765962001561 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 765962001562 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 765962001563 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 765962001564 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 765962001565 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 765962001566 dimer interface [polypeptide binding]; other site 765962001567 substrate binding site [chemical binding]; other site 765962001568 metal binding sites [ion binding]; metal-binding site 765962001569 MutS2 family protein; Region: mutS2; TIGR01069 765962001570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962001571 Walker A/P-loop; other site 765962001572 ATP binding site [chemical binding]; other site 765962001573 Q-loop/lid; other site 765962001574 ABC transporter signature motif; other site 765962001575 Walker B; other site 765962001576 D-loop; other site 765962001577 H-loop/switch region; other site 765962001578 Smr domain; Region: Smr; cl02619 765962001579 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 765962001580 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765962001581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765962001582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765962001583 aspartate aminotransferase; Provisional; Region: PRK08361 765962001584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765962001585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962001586 homodimer interface [polypeptide binding]; other site 765962001587 catalytic residue [active] 765962001588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 765962001589 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 765962001590 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 765962001591 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 765962001592 putative trimer interface [polypeptide binding]; other site 765962001593 putative CoA binding site [chemical binding]; other site 765962001594 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765962001595 Sel1 repeat; Region: Sel1; cl02723 765962001596 Sel1 repeat; Region: Sel1; cl02723 765962001597 Protein of unknown function DUF262; Region: DUF262; cl14890 765962001598 Protein of unknown function DUF262; Region: DUF262; cl14890 765962001599 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 765962001600 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 765962001601 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 765962001602 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 765962001603 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 765962001604 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 765962001605 nickel binding site [ion binding]; other site 765962001606 putative substrate-binding site; other site 765962001607 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001608 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 765962001609 Ligand Binding Site [chemical binding]; other site 765962001610 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 765962001611 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765962001612 active site 765962001613 NTP binding site [chemical binding]; other site 765962001614 metal binding triad [ion binding]; metal-binding site 765962001615 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765962001616 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 765962001617 putative hydrophobic ligand binding site [chemical binding]; other site 765962001618 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 765962001619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962001620 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 765962001621 dimer interface [polypeptide binding]; other site 765962001622 FMN binding site [chemical binding]; other site 765962001623 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 765962001624 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765962001625 active site 765962001626 HIGH motif; other site 765962001627 nucleotide binding site [chemical binding]; other site 765962001628 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765962001629 active site 765962001630 KMSKS motif; other site 765962001631 YGGT family; Region: YGGT; cl00508 765962001632 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 765962001633 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 765962001634 N-acetyl-D-glucosamine binding site [chemical binding]; other site 765962001635 catalytic residue [active] 765962001636 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 765962001637 active site 765962001638 tetramer interface [polypeptide binding]; other site 765962001639 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 765962001640 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 765962001641 hinge; other site 765962001642 active site 765962001643 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 765962001644 Aspartase; Region: Aspartase; cd01357 765962001645 active sites [active] 765962001646 tetramer interface [polypeptide binding]; other site 765962001647 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 765962001648 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 765962001649 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 765962001650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 765962001651 motif II; other site 765962001652 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 765962001653 Ferritin-like domain; Region: Ferritin; pfam00210 765962001654 ferroxidase diiron center [ion binding]; other site 765962001655 hypothetical protein; Provisional; Region: PRK08444 765962001656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962001657 FeS/SAM binding site; other site 765962001658 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 765962001659 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765962001660 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765962001661 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765962001662 Surface antigen; Region: Bac_surface_Ag; cl03097 765962001663 hypothetical protein; Provisional; Region: PRK08445 765962001664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962001665 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 765962001666 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765962001667 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765962001668 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 765962001669 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 765962001670 GatB domain; Region: GatB_Yqey; cl11497 765962001671 SurA N-terminal domain; Region: SurA_N; pfam09312 765962001672 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 765962001673 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 765962001674 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 765962001675 RNA/DNA hybrid binding site [nucleotide binding]; other site 765962001676 active site 765962001677 ribonuclease III; Reviewed; Region: rnc; PRK00102 765962001678 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 765962001679 dimerization interface [polypeptide binding]; other site 765962001680 active site 765962001681 metal binding site [ion binding]; metal-binding site 765962001682 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 765962001683 dsRNA binding site [nucleotide binding]; other site 765962001684 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 765962001685 Tetramer interface [polypeptide binding]; other site 765962001686 Active site [active] 765962001687 FMN-binding site [chemical binding]; other site 765962001688 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 765962001689 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 765962001690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962001691 FeS/SAM binding site; other site 765962001692 HemN C-terminal region; Region: HemN_C; pfam06969 765962001693 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 765962001694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765962001695 Cysteine-rich domain; Region: CCG; pfam02754 765962001696 Cysteine-rich domain; Region: CCG; pfam02754 765962001697 Restriction endonuclease; Region: Mrr_cat; cl00747 765962001698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962001699 ATP binding site [chemical binding]; other site 765962001700 putative Mg++ binding site [ion binding]; other site 765962001701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962001702 nucleotide binding region [chemical binding]; other site 765962001703 ATP-binding site [chemical binding]; other site 765962001704 Predicted helicase [General function prediction only]; Region: COG4889 765962001705 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001706 aspartate aminotransferase; Provisional; Region: PRK08361 765962001707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765962001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962001709 homodimer interface [polypeptide binding]; other site 765962001710 catalytic residue [active] 765962001711 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765962001712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 765962001713 DNA binding site [nucleotide binding] 765962001714 Int/Topo IB signature motif; other site 765962001715 active site 765962001716 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 765962001717 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 765962001718 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765962001719 DNA binding site [nucleotide binding] 765962001720 active site 765962001721 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 765962001722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962001723 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 765962001724 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 765962001725 ATP cone domain; Region: ATP-cone; pfam03477 765962001726 Class I ribonucleotide reductase; Region: RNR_I; cd01679 765962001727 active site 765962001728 dimer interface [polypeptide binding]; other site 765962001729 catalytic residues [active] 765962001730 effector binding site; other site 765962001731 R2 peptide binding site; other site 765962001732 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 765962001733 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 765962001734 Substrate binding site [chemical binding]; other site 765962001735 Mg++ binding site [ion binding]; other site 765962001736 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 765962001737 active site 765962001738 substrate binding site [chemical binding]; other site 765962001739 CoA binding site [chemical binding]; other site 765962001740 FliP family; Region: FliP; cl00593 765962001741 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 765962001742 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 765962001743 N-terminal plug; other site 765962001744 ligand-binding site [chemical binding]; other site 765962001745 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 765962001746 ferrous iron transporter FeoB; Region: feoB; TIGR00437 765962001747 G1 box; other site 765962001748 GTP/Mg2+ binding site [chemical binding]; other site 765962001749 Switch I region; other site 765962001750 G2 box; other site 765962001751 G3 box; other site 765962001752 Switch II region; other site 765962001753 G4 box; other site 765962001754 G5 box; other site 765962001755 Nucleoside recognition; Region: Gate; cl00486 765962001756 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 765962001757 Nucleoside recognition; Region: Gate; cl00486 765962001758 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 765962001759 active site 765962001760 catalytic site [active] 765962001761 substrate binding site [chemical binding]; other site 765962001762 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 765962001763 putative acyltransferase; Provisional; Region: PRK05790 765962001764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 765962001765 dimer interface [polypeptide binding]; other site 765962001766 active site 765962001767 Coenzyme A transferase; Region: CoA_trans; cl00773 765962001768 Coenzyme A transferase; Region: CoA_trans; cl00773 765962001769 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962001770 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 765962001771 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 765962001772 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 765962001773 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 765962001774 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 765962001775 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; cl01902 765962001776 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 765962001777 DNA gyrase subunit A; Validated; Region: PRK05560 765962001778 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 765962001779 CAP-like domain; other site 765962001780 Active site [active] 765962001781 primary dimer interface [polypeptide binding]; other site 765962001782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765962001788 Response regulator receiver domain; Region: Response_reg; pfam00072 765962001789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962001790 active site 765962001791 phosphorylation site [posttranslational modification] 765962001792 intermolecular recognition site; other site 765962001793 dimerization interface [polypeptide binding]; other site 765962001794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962001795 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 765962001796 Walker A motif; other site 765962001797 ATP binding site [chemical binding]; other site 765962001798 Walker B motif; other site 765962001799 arginine finger; other site 765962001800 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765962001801 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765962001802 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765962001803 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 765962001804 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001805 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 765962001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962001807 Uncharacterized conserved protein [Function unknown]; Region: COG1912 765962001808 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 765962001809 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001810 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 765962001811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 765962001812 Fic family protein [Function unknown]; Region: COG3177 765962001813 Fic/DOC family; Region: Fic; cl00960 765962001814 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 765962001815 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 765962001816 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 765962001817 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 765962001818 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 765962001819 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 765962001820 Walker A/P-loop; other site 765962001821 ATP binding site [chemical binding]; other site 765962001822 Q-loop/lid; other site 765962001823 ABC transporter signature motif; other site 765962001824 Walker B; other site 765962001825 D-loop; other site 765962001826 H-loop/switch region; other site 765962001827 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 765962001828 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 765962001829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962001830 Walker A motif; other site 765962001831 ATP binding site [chemical binding]; other site 765962001832 Walker B motif; other site 765962001833 arginine finger; other site 765962001834 LysE type translocator; Region: LysE; cl00565 765962001835 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 765962001836 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 765962001837 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001838 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 765962001839 tetramer interface [polypeptide binding]; other site 765962001840 active site/substrate binding site [active] 765962001841 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 765962001842 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962001843 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 765962001844 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 765962001845 FMN binding site [chemical binding]; other site 765962001846 active site 765962001847 catalytic residues [active] 765962001848 substrate binding site [chemical binding]; other site 765962001849 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 765962001850 Ligand Binding Site [chemical binding]; other site 765962001851 Radical SAM; Region: Elp3; smart00729 765962001852 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962001853 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 765962001854 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765962001855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962001856 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 765962001857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962001858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765962001859 catalytic residue [active] 765962001860 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 765962001861 tetramer interfaces [polypeptide binding]; other site 765962001862 binuclear metal-binding site [ion binding]; other site 765962001863 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 765962001864 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 765962001865 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 765962001866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765962001867 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 765962001868 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765962001869 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 765962001870 nucleotide binding site/active site [active] 765962001871 HIT family signature motif; other site 765962001872 catalytic residue [active] 765962001873 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 765962001874 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 765962001875 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 765962001876 Predicted GTPase [General function prediction only]; Region: COG3596 765962001877 Domain of unknown function (DUF697); Region: DUF697; cl12064 765962001878 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962001879 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 765962001880 G1 box; other site 765962001881 G1 box; other site 765962001882 GTP/Mg2+ binding site [chemical binding]; other site 765962001883 GTP/Mg2+ binding site [chemical binding]; other site 765962001884 Switch I region; other site 765962001885 G2 box; other site 765962001886 Switch II region; other site 765962001887 G3 box; other site 765962001888 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765962001889 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 765962001890 active site 765962001891 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 765962001892 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 765962001893 Interdomain contacts; other site 765962001894 Cytokine receptor motif; other site 765962001895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962001896 S-adenosylmethionine binding site [chemical binding]; other site 765962001897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765962001898 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765962001899 Walker A/P-loop; other site 765962001900 ATP binding site [chemical binding]; other site 765962001901 Q-loop/lid; other site 765962001902 ABC transporter signature motif; other site 765962001903 Walker B; other site 765962001904 D-loop; other site 765962001905 H-loop/switch region; other site 765962001906 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 765962001907 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765962001908 Peptidase family M23; Region: Peptidase_M23; pfam01551 765962001909 FlaG protein; Region: FlaG; cl00591 765962001910 flagellar capping protein; Validated; Region: fliD; PRK08453 765962001911 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 765962001912 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 765962001913 Flagellar protein FliS; Region: FliS; cl00654 765962001914 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 765962001915 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 765962001916 putative ATP binding site [chemical binding]; other site 765962001917 putative substrate interface [chemical binding]; other site 765962001918 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 765962001919 N-carbamolyputrescine amidase; Region: PLN02747 765962001920 putative active site; other site 765962001921 catalytic triad [active] 765962001922 putative dimer interface [polypeptide binding]; other site 765962001923 Predicted permease [General function prediction only]; Region: COG2056 765962001924 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962001925 putative efflux protein, MATE family; Region: matE; TIGR00797 765962001926 MatE; Region: MatE; pfam01554 765962001927 MatE; Region: MatE; pfam01554 765962001928 phosphodiesterase; Provisional; Region: PRK12704 765962001929 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 765962001930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765962001931 Zn2+ binding site [ion binding]; other site 765962001932 Mg2+ binding site [ion binding]; other site 765962001933 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 765962001934 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 765962001935 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765962001936 P loop; other site 765962001937 GTP binding site [chemical binding]; other site 765962001938 Flagellin N-methylase; Region: FliB; cl00497 765962001939 transcriptional activator RhaR; Provisional; Region: PRK13501 765962001940 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 765962001941 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 765962001942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962001943 FeS/SAM binding site; other site 765962001944 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 765962001945 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 765962001946 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 765962001947 GTP binding site [chemical binding]; other site 765962001948 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 765962001949 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 765962001950 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 765962001951 active site 765962001952 metal binding site [ion binding]; metal-binding site 765962001953 Nitronate monooxygenase; Region: NMO; pfam03060 765962001954 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 765962001955 FMN binding site [chemical binding]; other site 765962001956 substrate binding site [chemical binding]; other site 765962001957 putative catalytic residue [active] 765962001958 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 765962001959 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 765962001960 active site 765962001961 HIGH motif; other site 765962001962 dimer interface [polypeptide binding]; other site 765962001963 KMSKS motif; other site 765962001964 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765962001965 RNA binding surface [nucleotide binding]; other site 765962001966 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 765962001967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 765962001968 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 765962001969 synthetase active site [active] 765962001970 NTP binding site [chemical binding]; other site 765962001971 metal binding site [ion binding]; metal-binding site 765962001972 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 765962001973 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 765962001974 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 765962001975 putative nucleotide binding site [chemical binding]; other site 765962001976 uridine monophosphate binding site [chemical binding]; other site 765962001977 homohexameric interface [polypeptide binding]; other site 765962001978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765962001979 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 765962001980 aconitate hydratase 2; Region: acnB; TIGR00117 765962001981 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 765962001982 substrate binding site [chemical binding]; other site 765962001983 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 765962001984 substrate binding site [chemical binding]; other site 765962001985 ligand binding site [chemical binding]; other site 765962001986 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 765962001987 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962001988 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 765962001989 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 765962001990 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 765962001991 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 765962001992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962001993 nucleotide binding region [chemical binding]; other site 765962001994 ATP-binding site [chemical binding]; other site 765962001995 SEC-C motif; Region: SEC-C; cl12132 765962001996 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 765962001997 FtsX-like permease family; Region: FtsX; pfam02687 765962001998 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962001999 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 765962002000 cofactor binding site; other site 765962002001 DNA binding site [nucleotide binding] 765962002002 substrate interaction site [chemical binding]; other site 765962002003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002004 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 765962002005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765962002006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962002007 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 765962002008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962002009 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 765962002010 active site 765962002011 catalytic residues [active] 765962002012 metal binding site [ion binding]; metal-binding site 765962002013 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765962002014 oligomer interface [polypeptide binding]; other site 765962002015 active site residues [active] 765962002016 trigger factor; Provisional; Region: tig; PRK01490 765962002017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765962002018 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 765962002019 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002020 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 765962002021 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 765962002022 trimer interface [polypeptide binding]; other site 765962002023 dimer interface [polypeptide binding]; other site 765962002024 putative active site [active] 765962002025 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 765962002026 MPT binding site; other site 765962002027 trimer interface [polypeptide binding]; other site 765962002028 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 765962002029 MoaE homodimer interface [polypeptide binding]; other site 765962002030 MoaD interaction [polypeptide binding]; other site 765962002031 active site residues [active] 765962002032 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 765962002033 MoaE interaction surface [polypeptide binding]; other site 765962002034 MoeB interaction surface [polypeptide binding]; other site 765962002035 thiocarboxylated glycine; other site 765962002036 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 765962002037 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 765962002038 dimerization interface [polypeptide binding]; other site 765962002039 active site 765962002040 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 765962002041 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 765962002042 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 765962002043 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 765962002044 Protein of unknown function DUF45; Region: DUF45; cl00636 765962002045 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 765962002046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 765962002047 N-terminal plug; other site 765962002048 ligand-binding site [chemical binding]; other site 765962002049 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 765962002050 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 765962002051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002052 Uncharacterized conserved protein [Function unknown]; Region: COG1565 765962002053 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 765962002054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765962002055 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 765962002056 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 765962002057 ATP binding site [chemical binding]; other site 765962002058 substrate interface [chemical binding]; other site 765962002059 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 765962002060 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765962002061 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 765962002062 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 765962002063 ligand binding site [chemical binding]; other site 765962002064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 765962002065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765962002066 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 765962002067 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765962002068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962002069 Walker A/P-loop; other site 765962002070 ATP binding site [chemical binding]; other site 765962002071 Q-loop/lid; other site 765962002072 ABC transporter signature motif; other site 765962002073 Walker B; other site 765962002074 D-loop; other site 765962002075 H-loop/switch region; other site 765962002076 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 765962002077 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 765962002078 UvrB/uvrC motif; Region: UVR; pfam02151 765962002079 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 765962002080 homoserine dehydrogenase; Provisional; Region: PRK06349 765962002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002082 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 765962002083 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 765962002084 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 765962002085 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765962002086 catalytic residues [active] 765962002087 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 765962002088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 765962002089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 765962002090 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 765962002091 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 765962002092 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 765962002093 RNA/DNA binding site [nucleotide binding]; other site 765962002094 ATP synthase A chain; Region: ATP-synt_A; cl00413 765962002095 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 765962002096 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 765962002097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 765962002098 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 765962002099 active site 765962002100 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 765962002101 indole acetimide hydrolase; Validated; Region: PRK07488 765962002102 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 765962002103 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 765962002104 CoA-binding site [chemical binding]; other site 765962002105 ATP-binding [chemical binding]; other site 765962002106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002107 spermidine synthase; Provisional; Region: PRK00811 765962002108 GTP-binding protein Der; Reviewed; Region: PRK00093 765962002109 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 765962002110 G1 box; other site 765962002111 GTP/Mg2+ binding site [chemical binding]; other site 765962002112 Switch I region; other site 765962002113 G2 box; other site 765962002114 Switch II region; other site 765962002115 G3 box; other site 765962002116 G4 box; other site 765962002117 G5 box; other site 765962002118 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 765962002119 G1 box; other site 765962002120 GTP/Mg2+ binding site [chemical binding]; other site 765962002121 Switch I region; other site 765962002122 G2 box; other site 765962002123 G3 box; other site 765962002124 Switch II region; other site 765962002125 G4 box; other site 765962002126 G5 box; other site 765962002127 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 765962002128 IHF dimer interface [polypeptide binding]; other site 765962002129 IHF - DNA interface [nucleotide binding]; other site 765962002130 potential protein location (hypothetical protein HPSJM_04245 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-R) 765962002131 Protein of unknown function, DUF400; Region: DUF400; cl01141 765962002132 Protein of unknown function, DUF400; Region: DUF400; cl01141 765962002133 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 765962002134 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 765962002135 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 765962002136 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 765962002137 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 765962002138 NAD(P) binding site [chemical binding]; other site 765962002139 homodimer interface [polypeptide binding]; other site 765962002140 substrate binding site [chemical binding]; other site 765962002141 active site 765962002142 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 765962002143 Flavoprotein; Region: Flavoprotein; cl08021 765962002144 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 765962002145 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 765962002146 thiamine phosphate binding site [chemical binding]; other site 765962002147 active site 765962002148 pyrophosphate binding site [ion binding]; other site 765962002149 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 765962002150 dimer interface [polypeptide binding]; other site 765962002151 substrate binding site [chemical binding]; other site 765962002152 ATP binding site [chemical binding]; other site 765962002153 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 765962002154 substrate binding site [chemical binding]; other site 765962002155 multimerization interface [polypeptide binding]; other site 765962002156 ATP binding site [chemical binding]; other site 765962002157 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 765962002158 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 765962002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962002160 ATP binding site [chemical binding]; other site 765962002161 putative Mg++ binding site [ion binding]; other site 765962002162 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 765962002163 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962002164 potential frameshift: common BLAST hit: gi|188527305|ref|YP_001909992.1| type I restriction enzyme M protein (hsdM) 765962002165 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 765962002166 active site 765962002167 Protein of unknown function (DUF511); Region: DUF511; cl01114 765962002168 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 765962002169 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 765962002170 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 765962002171 ABC transporter; Region: ABC_tran_2; pfam12848 765962002172 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 765962002173 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 765962002174 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 765962002175 active site 765962002176 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 765962002177 dimer interface [polypeptide binding]; other site 765962002178 active site 765962002179 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 765962002180 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 765962002181 putative ribose interaction site [chemical binding]; other site 765962002182 putative ADP binding site [chemical binding]; other site 765962002183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765962002184 active site 765962002185 nucleotide binding site [chemical binding]; other site 765962002186 HIGH motif; other site 765962002187 KMSKS motif; other site 765962002188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002189 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 765962002190 NAD(P) binding site [chemical binding]; other site 765962002191 active site 765962002192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 765962002193 active site 765962002194 motif I; other site 765962002195 motif II; other site 765962002196 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 765962002197 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 765962002198 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765962002199 trimer interface [polypeptide binding]; other site 765962002200 active site 765962002201 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 765962002202 domain; Region: GreA_GreB_N; pfam03449 765962002203 C-term; Region: GreA_GreB; pfam01272 765962002204 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 765962002205 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 765962002206 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 765962002207 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 765962002208 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 765962002209 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 765962002210 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 765962002211 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 765962002212 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 765962002213 alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686 765962002214 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 765962002215 PhnA protein; Region: PhnA; pfam03831 765962002216 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 765962002217 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 765962002218 tetramer interface [polypeptide binding]; other site 765962002219 heme binding pocket [chemical binding]; other site 765962002220 NADPH binding site [chemical binding]; other site 765962002221 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 765962002222 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 765962002223 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 765962002224 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 765962002225 active site 765962002226 putative DNA-binding cleft [nucleotide binding]; other site 765962002227 dimer interface [polypeptide binding]; other site 765962002228 Uncharacterized conserved protein [Function unknown]; Region: COG1432 765962002229 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 765962002230 putative metal binding site [ion binding]; other site 765962002231 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 765962002232 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 765962002233 RuvA N terminal domain; Region: RuvA_N; pfam01330 765962002234 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 765962002235 Protein of unknown function (DUF342); Region: DUF342; pfam03961 765962002236 MviN-like protein; Region: MVIN; pfam03023 765962002237 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 765962002238 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 765962002239 active site 765962002240 HIGH motif; other site 765962002241 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 765962002242 KMSKS motif; other site 765962002243 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765962002244 tRNA binding surface [nucleotide binding]; other site 765962002245 anticodon binding site; other site 765962002246 Vacuolating cyotoxin; Region: VacA; pfam02691 765962002247 Autotransporter beta-domain; Region: Autotransporter; cl02365 765962002248 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 765962002249 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 765962002250 Ligand binding site [chemical binding]; other site 765962002251 metal binding site [ion binding]; metal-binding site 765962002252 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765962002253 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765962002254 Walker A/P-loop; other site 765962002255 ATP binding site [chemical binding]; other site 765962002256 Q-loop/lid; other site 765962002257 ABC transporter signature motif; other site 765962002258 Walker B; other site 765962002259 D-loop; other site 765962002260 H-loop/switch region; other site 765962002261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 765962002262 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 765962002263 ABC-ATPase subunit interface; other site 765962002264 dimer interface [polypeptide binding]; other site 765962002265 putative PBP binding regions; other site 765962002266 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765962002267 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 765962002268 NADP binding site [chemical binding]; other site 765962002269 active site 765962002270 steroid binding site; other site 765962002271 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 765962002272 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 765962002273 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 765962002274 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002275 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 765962002276 Hydrogenase formation hypA family; Region: HypD; cl12072 765962002277 HupF/HypC family; Region: HupF_HypC; cl00394 765962002278 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962002279 Cupin domain; Region: Cupin_2; cl09118 765962002280 Acetokinase family; Region: Acetate_kinase; cl01029 765962002281 Acetokinase family; Region: Acetate_kinase; cl01029 765962002282 potential frameshift: common BLAST hit: gi|15611908|ref|NP_223559.1| phosphotransacetylase 765962002283 potential frameshift: common BLAST hit: gi|15611908|ref|NP_223559.1| phosphotransacetylase 765962002284 potential frameshift: common BLAST hit: gi|15611908|ref|NP_223559.1| phosphotransacetylase 765962002285 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 765962002286 Flagellar hook capping protein; Region: FlgD; cl04347 765962002287 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 765962002288 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 765962002289 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 765962002290 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 765962002291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002292 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 765962002293 UvrD/REP helicase; Region: UvrD-helicase; cl14126 765962002294 UvrD/REP helicase; Region: UvrD-helicase; cl14126 765962002295 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002296 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002297 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962002298 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 765962002299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 765962002300 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 765962002301 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 765962002302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765962002303 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 765962002304 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 765962002305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765962002306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 765962002307 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 765962002308 IMP binding site; other site 765962002309 dimer interface [polypeptide binding]; other site 765962002310 interdomain contacts; other site 765962002311 partial ornithine binding site; other site 765962002312 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 765962002313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002314 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 765962002315 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765962002316 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962002317 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962002318 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 765962002319 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 765962002320 Autotransporter beta-domain; Region: Autotransporter; cl02365 765962002321 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002322 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 765962002323 active site 1 [active] 765962002324 dimer interface [polypeptide binding]; other site 765962002325 hexamer interface [polypeptide binding]; other site 765962002326 active site 2 [active] 765962002327 recombination protein RecR; Region: recR; TIGR00615 765962002328 RecR protein; Region: RecR; pfam02132 765962002329 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 765962002330 putative active site [active] 765962002331 putative metal-binding site [ion binding]; other site 765962002332 tetramer interface [polypeptide binding]; other site 765962002333 tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094 765962002334 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 765962002335 Permutation of conserved domain; other site 765962002336 active site 765962002337 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 765962002338 Peptidase family M48; Region: Peptidase_M48; cl12018 765962002339 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765962002340 GTP cyclohydrolase I; Provisional; Region: PLN03044 765962002341 active site 765962002342 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765962002343 substrate binding pocket [chemical binding]; other site 765962002344 chain length determination region; other site 765962002345 substrate-Mg2+ binding site; other site 765962002346 catalytic residues [active] 765962002347 aspartate-rich region 1; other site 765962002348 active site lid residues [active] 765962002349 aspartate-rich region 2; other site 765962002350 Survival protein SurE; Region: SurE; cl00448 765962002351 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765962002352 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 765962002353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962002354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765962002355 Coenzyme A binding pocket [chemical binding]; other site 765962002356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765962002357 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765962002359 putative substrate translocation pore; other site 765962002360 Protein of unknown function DUF262; Region: DUF262; cl14890 765962002361 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 765962002362 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 765962002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962002364 dimer interface [polypeptide binding]; other site 765962002365 conserved gate region; other site 765962002366 putative PBP binding loops; other site 765962002367 ABC-ATPase subunit interface; other site 765962002368 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 765962002369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 765962002370 substrate binding pocket [chemical binding]; other site 765962002371 membrane-bound complex binding site; other site 765962002372 hinge residues; other site 765962002373 alanine racemase; Region: alr; TIGR00492 765962002374 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 765962002375 active site 765962002376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765962002377 dimer interface [polypeptide binding]; other site 765962002378 substrate binding site [chemical binding]; other site 765962002379 catalytic residues [active] 765962002380 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765962002381 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 765962002382 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 765962002383 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 765962002384 homotrimer interaction site [polypeptide binding]; other site 765962002385 putative active site [active] 765962002386 potential protein location (hypothetical protein HPSJM_04815 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-G) 765962002387 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 765962002388 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 765962002389 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 765962002390 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 765962002391 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 765962002392 putative recombination protein RecO; Provisional; Region: PRK13908 765962002393 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 765962002394 Competence-damaged protein; Region: CinA; cl00666 765962002395 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 765962002396 dimer interface [polypeptide binding]; other site 765962002397 FMN binding site [chemical binding]; other site 765962002398 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 765962002399 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 765962002400 active site 765962002401 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 765962002402 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 765962002403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765962002404 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 765962002405 Putative zinc ribbon domain; Region: DUF164; pfam02591 765962002406 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 765962002407 Uncharacterized conserved protein [Function unknown]; Region: COG0327 765962002408 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 765962002409 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 765962002410 dimer interface [polypeptide binding]; other site 765962002411 motif 1; other site 765962002412 active site 765962002413 motif 2; other site 765962002414 motif 3; other site 765962002415 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 765962002416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002417 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 765962002418 potential frameshift: common BLAST hit: gi|254779561|ref|YP_003057667.1| putative ATPase 765962002419 potential frameshift: common BLAST hit: gi|210135153|ref|YP_002301592.1| ATP/GTP-binding protein 765962002420 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 765962002421 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 765962002422 Outer membrane efflux protein; Region: OEP; pfam02321 765962002423 Outer membrane efflux protein; Region: OEP; pfam02321 765962002424 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 765962002425 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 765962002426 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 765962002427 Sulfatase; Region: Sulfatase; cl10460 765962002428 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 765962002429 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 765962002430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 765962002431 inhibitor-cofactor binding pocket; inhibition site 765962002432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962002433 catalytic residue [active] 765962002434 periplasmic folding chaperone; Provisional; Region: PRK10788 765962002435 cell division protein FtsA; Region: ftsA; TIGR01174 765962002436 Cell division protein FtsA; Region: FtsA; cl11496 765962002437 Cell division protein FtsA; Region: FtsA; cl11496 765962002438 cell division protein FtsZ; Validated; Region: PRK09330 765962002439 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 765962002440 nucleotide binding site [chemical binding]; other site 765962002441 SulA interaction site; other site 765962002442 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765962002443 Protein of unknown function DUF262; Region: DUF262; cl14890 765962002444 Protein of unknown function DUF262; Region: DUF262; cl14890 765962002445 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 765962002446 DHH family; Region: DHH; pfam01368 765962002447 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 765962002448 arginine decarboxylase, biosynthetic; Region: speA; TIGR01273 765962002449 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 765962002450 active site 765962002451 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765962002452 catalytic residues [active] 765962002453 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 765962002454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765962002455 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 765962002456 putative ADP-binding pocket [chemical binding]; other site 765962002457 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 765962002458 tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068 765962002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962002460 S-adenosylmethionine binding site [chemical binding]; other site 765962002461 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 765962002462 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 765962002463 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 765962002464 active site 765962002465 HIGH motif; other site 765962002466 KMSKS motif; other site 765962002467 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 765962002468 tRNA binding surface [nucleotide binding]; other site 765962002469 anticodon binding site; other site 765962002470 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 765962002471 dimer interface [polypeptide binding]; other site 765962002472 putative tRNA-binding site [nucleotide binding]; other site 765962002473 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 765962002474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962002475 S-adenosylmethionine binding site [chemical binding]; other site 765962002476 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765962002477 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 765962002478 GMP synthase; Reviewed; Region: guaA; PRK00074 765962002479 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 765962002480 AMP/PPi binding site [chemical binding]; other site 765962002481 candidate oxyanion hole; other site 765962002482 catalytic triad [active] 765962002483 potential glutamine specificity residues [chemical binding]; other site 765962002484 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 765962002485 ATP Binding subdomain [chemical binding]; other site 765962002486 Ligand Binding sites [chemical binding]; other site 765962002487 Dimerization subdomain; other site 765962002488 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 765962002489 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 765962002490 molybdopterin cofactor binding site [chemical binding]; other site 765962002491 substrate binding site [chemical binding]; other site 765962002492 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 765962002493 molybdopterin cofactor binding site; other site 765962002494 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765962002495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962002496 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962002497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765962002498 catalytic residue [active] 765962002499 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 765962002500 nucleotide binding site/active site [active] 765962002501 HIT family signature motif; other site 765962002502 catalytic residue [active] 765962002503 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 765962002504 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 765962002505 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 765962002506 dimer interface [polypeptide binding]; other site 765962002507 motif 1; other site 765962002508 active site 765962002509 motif 2; other site 765962002510 motif 3; other site 765962002511 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 765962002512 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 765962002513 putative tRNA-binding site [nucleotide binding]; other site 765962002514 tRNA synthetase B5 domain; Region: B5; cl08394 765962002515 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 765962002516 dimer interface [polypeptide binding]; other site 765962002517 motif 1; other site 765962002518 motif 3; other site 765962002519 motif 2; other site 765962002520 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 765962002521 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 765962002522 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 765962002523 hinge; other site 765962002524 active site 765962002525 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 765962002526 LytB protein; Region: LYTB; cl00507 765962002527 ribosomal protein S1; Region: rpsA; TIGR00717 765962002528 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 765962002529 RNA binding site [nucleotide binding]; other site 765962002530 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 765962002531 RNA binding site [nucleotide binding]; other site 765962002532 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 765962002533 RNA binding site [nucleotide binding]; other site 765962002534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 765962002535 RNA binding site [nucleotide binding]; other site 765962002536 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 765962002537 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 765962002538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002539 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 765962002540 putative L-serine binding site [chemical binding]; other site 765962002541 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 765962002542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 765962002543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765962002544 catalytic residue [active] 765962002545 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 765962002546 putative active site [active] 765962002547 putative metal binding site [ion binding]; other site 765962002548 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765962002549 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 765962002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962002551 active site 765962002552 phosphorylation site [posttranslational modification] 765962002553 intermolecular recognition site; other site 765962002554 dimerization interface [polypeptide binding]; other site 765962002555 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 765962002556 putative binding surface; other site 765962002557 active site 765962002558 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 765962002559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765962002560 ATP binding site [chemical binding]; other site 765962002561 Mg2+ binding site [ion binding]; other site 765962002562 G-X-G motif; other site 765962002563 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 765962002564 Response regulator receiver domain; Region: Response_reg; pfam00072 765962002565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962002566 active site 765962002567 phosphorylation site [posttranslational modification] 765962002568 intermolecular recognition site; other site 765962002569 dimerization interface [polypeptide binding]; other site 765962002570 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 765962002571 putative CheA interaction surface; other site 765962002572 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 765962002573 dimer interface [polypeptide binding]; other site 765962002574 catalytic triad [active] 765962002575 peroxidatic and resolving cysteines [active] 765962002576 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 765962002577 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 765962002578 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765962002579 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 765962002580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962002581 S-adenosylmethionine binding site [chemical binding]; other site 765962002582 primosome assembly protein PriA; Validated; Region: PRK05580 765962002583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962002584 ATP binding site [chemical binding]; other site 765962002585 putative Mg++ binding site [ion binding]; other site 765962002586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962002587 Sporulation related domain; Region: SPOR; cl10051 765962002588 Peptidase family M48; Region: Peptidase_M48; cl12018 765962002589 HemK family putative methylases; Region: hemK_fam; TIGR00536 765962002590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002591 glutamate dehydrogenase; Provisional; Region: PRK09414 765962002592 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 765962002593 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 765962002594 NAD(P) binding site [chemical binding]; other site 765962002595 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 765962002596 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 765962002597 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 765962002598 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon...; Region: SoxW; cd02951 765962002599 catalytic residues [active] 765962002600 ferrochelatase; Region: hemH; TIGR00109 765962002601 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 765962002602 C-terminal domain interface [polypeptide binding]; other site 765962002603 active site 765962002604 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 765962002605 active site 765962002606 N-terminal domain interface [polypeptide binding]; other site 765962002607 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 765962002608 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002609 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765962002610 trimer interface [polypeptide binding]; other site 765962002611 active site 765962002612 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 765962002613 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 765962002614 carboxyltransferase (CT) interaction site; other site 765962002615 biotinylation site [posttranslational modification]; other site 765962002616 biotin carboxylase; Validated; Region: PRK08462 765962002617 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765962002618 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 765962002619 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 765962002620 potential frameshift: common BLAST hit: gi|210135246|ref|YP_002301685.1| type II R-M system restriction endonuclease 765962002621 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 765962002622 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 765962002623 inhibitor-cofactor binding pocket; inhibition site 765962002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962002625 catalytic residue [active] 765962002626 potential protein location (hypothetical protein HPSJM_05370 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-L) 765962002627 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 765962002628 dimer interface [polypeptide binding]; other site 765962002629 putative radical transfer pathway; other site 765962002630 diiron center [ion binding]; other site 765962002631 tyrosyl radical; other site 765962002632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962002633 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 765962002634 pseudouridylate synthase I; Region: hisT_truA; TIGR00071 765962002635 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 765962002636 dimerization interface 3.5A [polypeptide binding]; other site 765962002637 active site 765962002638 UDP-glucose-4-epimerase; Region: galE; TIGR01179 765962002639 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765962002640 NAD binding site [chemical binding]; other site 765962002641 homodimer interface [polypeptide binding]; other site 765962002642 active site 765962002643 substrate binding site [chemical binding]; other site 765962002644 potential protein location (hypothetical protein HPSJM_05400 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-I) 765962002645 potential protein location (hypothetical protein HPSJM_05405 [Helicobacter pylori SJM180]) that overlaps RNA (tRNA-A) 765962002646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 765962002647 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 765962002648 putative NAD(P) binding site [chemical binding]; other site 765962002649 homodimer interface [polypeptide binding]; other site 765962002650 homotetramer interface [polypeptide binding]; other site 765962002651 active site 765962002652 Sel1 repeat; Region: Sel1; cl02723 765962002653 Sel1 repeat; Region: Sel1; cl02723 765962002654 Sel1 repeat; Region: Sel1; cl02723 765962002655 Sel1 repeat; Region: Sel1; cl02723 765962002656 Sel1 repeat; Region: Sel1; cl02723 765962002657 Entner-Doudoroff aldolase; Region: eda; TIGR01182 765962002658 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 765962002659 active site 765962002660 intersubunit interface [polypeptide binding]; other site 765962002661 catalytic residue [active] 765962002662 Dehydratase family; Region: ILVD_EDD; cl00340 765962002663 6-phosphogluconate dehydratase; Region: edd; TIGR01196 765962002664 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 765962002665 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 765962002666 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 765962002667 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 765962002668 putative active site [active] 765962002669 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 765962002670 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765962002671 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 765962002672 putative NAD(P) binding site [chemical binding]; other site 765962002673 putative substrate binding site [chemical binding]; other site 765962002674 catalytic Zn binding site [ion binding]; other site 765962002675 structural Zn binding site [ion binding]; other site 765962002676 dimer interface [polypeptide binding]; other site 765962002677 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 765962002678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765962002679 active site 765962002680 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 765962002681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765962002682 active site 765962002683 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002684 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 765962002685 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 765962002686 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 765962002687 4Fe-4S binding domain; Region: Fer4; cl02805 765962002688 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 765962002689 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 765962002690 dimer interface [polypeptide binding]; other site 765962002691 PYR/PP interface [polypeptide binding]; other site 765962002692 TPP binding site [chemical binding]; other site 765962002693 substrate binding site [chemical binding]; other site 765962002694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765962002695 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 765962002696 TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea and some hyperthermophilic bacteria. PFOR catalyzes the...; Region: TPP_PFOR_porB_like; cd03376 765962002697 TPP-binding site [chemical binding]; other site 765962002698 putative dimer interface [polypeptide binding]; other site 765962002699 adenylosuccinate lyase; Provisional; Region: PRK08470 765962002700 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 765962002701 tetramer interface [polypeptide binding]; other site 765962002702 active site 765962002703 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 765962002704 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002705 excinuclease ABC subunit B; Provisional; Region: PRK05298 765962002706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962002707 ATP binding site [chemical binding]; other site 765962002708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962002709 nucleotide binding region [chemical binding]; other site 765962002710 ATP-binding site [chemical binding]; other site 765962002711 Ultra-violet resistance protein B; Region: UvrB; pfam12344 765962002712 UvrB/uvrC motif; Region: UVR; pfam02151 765962002713 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 765962002714 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 765962002715 Sel1 repeat; Region: Sel1; cl02723 765962002716 Sel1 repeat; Region: Sel1; cl02723 765962002717 Sel1 repeat; Region: Sel1; cl02723 765962002718 Sel1 repeat; Region: Sel1; cl02723 765962002719 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 765962002720 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 765962002721 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 765962002722 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 765962002723 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 765962002724 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 765962002725 cofactor binding site; other site 765962002726 DNA binding site [nucleotide binding] 765962002727 substrate interaction site [chemical binding]; other site 765962002728 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 765962002729 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765962002730 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765962002731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 765962002732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 765962002733 ligand binding site [chemical binding]; other site 765962002734 translocation protein TolB; Provisional; Region: tolB; PRK04043 765962002735 TolB amino-terminal domain; Region: TolB_N; pfam04052 765962002736 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 765962002737 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 765962002738 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765962002739 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 765962002740 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 765962002741 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 765962002742 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765962002743 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 765962002744 alpha subunit interaction interface [polypeptide binding]; other site 765962002745 Walker A motif; other site 765962002746 ATP binding site [chemical binding]; other site 765962002747 Walker B motif; other site 765962002748 inhibitor binding site; inhibition site 765962002749 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765962002750 ATP synthase; Region: ATP-synt; cl00365 765962002751 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 765962002752 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765962002753 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 765962002754 beta subunit interaction interface [polypeptide binding]; other site 765962002755 Walker A motif; other site 765962002756 ATP binding site [chemical binding]; other site 765962002757 Walker B motif; other site 765962002758 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765962002759 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 765962002760 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 765962002761 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 765962002762 ParB-like partition proteins; Region: parB_part; TIGR00180 765962002763 ParB-like nuclease domain; Region: ParBc; cl02129 765962002764 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 765962002765 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 765962002766 P-loop; other site 765962002767 Magnesium ion binding site [ion binding]; other site 765962002768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 765962002769 Magnesium ion binding site [ion binding]; other site 765962002770 biotin--protein ligase; Provisional; Region: PRK08477 765962002771 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765962002772 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 765962002773 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 765962002774 putative active site [active] 765962002775 substrate binding site [chemical binding]; other site 765962002776 putative cosubstrate binding site; other site 765962002777 catalytic site [active] 765962002778 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 765962002779 substrate binding site [chemical binding]; other site 765962002780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962002781 Walker A/P-loop; other site 765962002782 ATP binding site [chemical binding]; other site 765962002783 Q-loop/lid; other site 765962002784 ABC transporter signature motif; other site 765962002785 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 765962002786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 765962002787 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 765962002788 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 765962002789 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 765962002790 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 765962002791 RimM N-terminal domain; Region: RimM; pfam01782 765962002792 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 765962002793 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 765962002794 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 765962002795 signal recognition particle protein; Provisional; Region: PRK10867 765962002796 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 765962002797 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765962002798 P loop; other site 765962002799 GTP binding site [chemical binding]; other site 765962002800 Signal peptide binding domain; Region: SRP_SPB; pfam02978 765962002801 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 765962002802 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765962002803 active site 765962002804 HIGH motif; other site 765962002805 nucleotide binding site [chemical binding]; other site 765962002806 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 765962002807 active site 765962002808 KMSKS motif; other site 765962002809 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 765962002810 anticodon binding site; other site 765962002811 FliW protein; Region: FliW; cl00740 765962002812 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 765962002813 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 765962002814 active site 765962002815 homodimer interface [polypeptide binding]; other site 765962002816 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002817 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002818 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 765962002819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002820 Fic/DOC family; Region: Fic; cl00960 765962002821 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 765962002822 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 765962002823 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 765962002824 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 765962002825 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 765962002826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 765962002827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765962002828 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 765962002829 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 765962002830 active site 765962002831 dimer interface [polypeptide binding]; other site 765962002832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 765962002833 dimer interface [polypeptide binding]; other site 765962002834 active site 765962002835 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 765962002836 Carbon starvation protein CstA; Region: CstA; cl00856 765962002837 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 765962002838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962002839 dimer interface [polypeptide binding]; other site 765962002840 conserved gate region; other site 765962002841 putative PBP binding loops; other site 765962002842 ABC-ATPase subunit interface; other site 765962002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962002844 dimer interface [polypeptide binding]; other site 765962002845 conserved gate region; other site 765962002846 putative PBP binding loops; other site 765962002847 ABC-ATPase subunit interface; other site 765962002848 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765962002849 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 765962002850 Walker A/P-loop; other site 765962002851 ATP binding site [chemical binding]; other site 765962002852 Q-loop/lid; other site 765962002853 ABC transporter signature motif; other site 765962002854 Walker B; other site 765962002855 D-loop; other site 765962002856 H-loop/switch region; other site 765962002857 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 765962002858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 765962002859 substrate binding pocket [chemical binding]; other site 765962002860 membrane-bound complex binding site; other site 765962002861 hinge residues; other site 765962002862 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 765962002863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 765962002864 Sulfate transporter family; Region: Sulfate_transp; cl00967 765962002865 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962002866 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 765962002867 Sulfatase; Region: Sulfatase; cl10460 765962002868 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 765962002869 nucleoside transporter; Region: nupC; TIGR00804 765962002870 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 765962002871 Nucleoside recognition; Region: Gate; cl00486 765962002872 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 765962002873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765962002874 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765962002875 putative substrate translocation pore; other site 765962002876 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 765962002877 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 765962002878 Ligand Binding Site [chemical binding]; other site 765962002879 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765962002880 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765962002881 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765962002882 MatE; Region: MatE; pfam01554 765962002883 MatE; Region: MatE; pfam01554 765962002884 putative arabinose transporter; Provisional; Region: PRK03545 765962002885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765962002886 putative substrate translocation pore; other site 765962002887 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 765962002888 active site 765962002889 zinc binding site [ion binding]; other site 765962002890 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 765962002891 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 765962002892 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 765962002893 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 765962002894 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 765962002895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962002896 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 765962002897 histidyl-tRNA synthetase; Region: hisS; TIGR00442 765962002898 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 765962002899 dimer interface [polypeptide binding]; other site 765962002900 motif 1; other site 765962002901 active site 765962002902 motif 2; other site 765962002903 motif 3; other site 765962002904 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 765962002905 anticodon binding site; other site 765962002906 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 765962002907 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765962002908 putative active site [active] 765962002909 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765962002910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 765962002911 active site 765962002912 catalytic tetrad [active] 765962002913 elongation factor G; Reviewed; Region: PRK00007 765962002914 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 765962002915 G1 box; other site 765962002916 putative GEF interaction site [polypeptide binding]; other site 765962002917 GTP/Mg2+ binding site [chemical binding]; other site 765962002918 Switch I region; other site 765962002919 G2 box; other site 765962002920 G3 box; other site 765962002921 Switch II region; other site 765962002922 G4 box; other site 765962002923 G5 box; other site 765962002924 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 765962002925 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 765962002926 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 765962002927 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 765962002928 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 765962002929 S17 interaction site [polypeptide binding]; other site 765962002930 S8 interaction site; other site 765962002931 16S rRNA interaction site [nucleotide binding]; other site 765962002932 streptomycin interaction site [chemical binding]; other site 765962002933 23S rRNA interaction site [nucleotide binding]; other site 765962002934 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 765962002935 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 765962002936 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 765962002937 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 765962002938 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765962002939 RPB11 interaction site [polypeptide binding]; other site 765962002940 RPB12 interaction site [polypeptide binding]; other site 765962002941 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765962002942 RPB3 interaction site [polypeptide binding]; other site 765962002943 RPB1 interaction site [polypeptide binding]; other site 765962002944 RPB11 interaction site [polypeptide binding]; other site 765962002945 RPB10 interaction site [polypeptide binding]; other site 765962002946 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 765962002947 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 765962002948 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 765962002949 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 765962002950 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 765962002951 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 765962002952 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 765962002953 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 765962002954 DNA binding site [nucleotide binding] 765962002955 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 765962002956 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 765962002957 core dimer interface [polypeptide binding]; other site 765962002958 peripheral dimer interface [polypeptide binding]; other site 765962002959 L10 interface [polypeptide binding]; other site 765962002960 L11 interface [polypeptide binding]; other site 765962002961 putative EF-Tu interaction site [polypeptide binding]; other site 765962002962 putative EF-G interaction site [polypeptide binding]; other site 765962002963 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 765962002964 23S rRNA interface [nucleotide binding]; other site 765962002965 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 765962002966 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 765962002967 mRNA/rRNA interface [nucleotide binding]; other site 765962002968 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 765962002969 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 765962002970 23S rRNA interface [nucleotide binding]; other site 765962002971 L7/L12 interface [polypeptide binding]; other site 765962002972 putative thiostrepton binding site; other site 765962002973 L25 interface [polypeptide binding]; other site 765962002974 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 765962002975 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 765962002976 putative homodimer interface [polypeptide binding]; other site 765962002977 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 765962002978 elongation factor Tu; Reviewed; Region: PRK00049 765962002979 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 765962002980 G1 box; other site 765962002981 GEF interaction site [polypeptide binding]; other site 765962002982 GTP/Mg2+ binding site [chemical binding]; other site 765962002983 Switch I region; other site 765962002984 G2 box; other site 765962002985 G3 box; other site 765962002986 Switch II region; other site 765962002987 G4 box; other site 765962002988 G5 box; other site 765962002989 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 765962002990 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 765962002991 Antibiotic Binding Site [chemical binding]; other site 765962002992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765962002993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962002994 Walker A/P-loop; other site 765962002995 ATP binding site [chemical binding]; other site 765962002996 Q-loop/lid; other site 765962002997 ABC transporter signature motif; other site 765962002998 Walker B; other site 765962002999 D-loop; other site 765962003000 H-loop/switch region; other site 765962003001 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 765962003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962003003 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 765962003004 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 765962003005 ICEA Protein; Region: ICEA; pfam05315 765962003006 serine O-acetyltransferase; Region: cysE; TIGR01172 765962003007 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 765962003008 trimer interface [polypeptide binding]; other site 765962003009 active site 765962003010 substrate binding site [chemical binding]; other site 765962003011 CoA binding site [chemical binding]; other site 765962003012 ATP synthase subunit C; Region: ATP-synt_C; cl00466 765962003013 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 765962003014 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 765962003015 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 765962003016 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 765962003017 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 765962003018 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 765962003019 putative nucleic acid binding region [nucleotide binding]; other site 765962003020 G-X-X-G motif; other site 765962003021 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 765962003022 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 765962003023 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 765962003024 Organic solvent tolerance protein; Region: OstA_C; pfam04453 765962003025 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 765962003026 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 765962003027 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 765962003028 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 765962003029 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 765962003030 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 765962003031 Walker A/P-loop; other site 765962003032 ATP binding site [chemical binding]; other site 765962003033 Q-loop/lid; other site 765962003034 ABC transporter signature motif; other site 765962003035 Walker B; other site 765962003036 D-loop; other site 765962003037 H-loop/switch region; other site 765962003038 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 765962003039 catalytic residue [active] 765962003040 putative FPP diphosphate binding site; other site 765962003041 putative FPP binding hydrophobic cleft; other site 765962003042 dimer interface [polypeptide binding]; other site 765962003043 putative IPP diphosphate binding site; other site 765962003044 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 765962003045 FAD binding domain; Region: FAD_binding_4; pfam01565 765962003046 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765962003047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765962003048 active site residue [active] 765962003049 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 765962003050 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 765962003051 active site 765962003052 CrcB-like protein; Region: CRCB; cl09114 765962003053 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 765962003054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962003055 FeS/SAM binding site; other site 765962003056 HemN C-terminal region; Region: HemN_C; pfam06969 765962003057 Cytochrome c; Region: Cytochrom_C; cl11414 765962003058 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 765962003059 putative active site [active] 765962003060 Ap4A binding site [chemical binding]; other site 765962003061 nudix motif; other site 765962003062 putative metal binding site [ion binding]; other site 765962003063 aspartate kinase; Reviewed; Region: PRK06635 765962003064 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 765962003065 putative nucleotide binding site [chemical binding]; other site 765962003066 putative catalytic residues [active] 765962003067 putative Mg ion binding site [ion binding]; other site 765962003068 putative aspartate binding site [chemical binding]; other site 765962003069 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 765962003070 putative allosteric regulatory site; other site 765962003071 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 765962003072 putative allosteric regulatory residue; other site 765962003073 DNA replication regulator; Region: HobA; pfam12163 765962003074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962003075 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 765962003076 dihydropteroate synthase; Region: DHPS; TIGR01496 765962003077 substrate binding pocket [chemical binding]; other site 765962003078 dimer interface [polypeptide binding]; other site 765962003079 inhibitor binding site; inhibition site 765962003080 EamA-like transporter family; Region: EamA; cl01037 765962003081 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 765962003082 EamA-like transporter family; Region: EamA; cl01037 765962003083 Protein of unknown function (DUF507); Region: DUF507; cl01112 765962003084 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 765962003085 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 765962003086 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 765962003087 catalytic site [active] 765962003088 subunit interface [polypeptide binding]; other site 765962003089 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 765962003090 Predicted amidohydrolase [General function prediction only]; Region: COG0388 765962003091 multimer interface [polypeptide binding]; other site 765962003092 active site 765962003093 catalytic triad [active] 765962003094 dimer interface [polypeptide binding]; other site 765962003095 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 765962003096 active site 765962003097 dimer interface [polypeptide binding]; other site 765962003098 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 765962003099 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 765962003100 motif 1; other site 765962003101 active site 765962003102 motif 2; other site 765962003103 motif 3; other site 765962003104 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 765962003105 DHHA1 domain; Region: DHHA1; pfam02272 765962003106 Protein of unknown function (DUF465); Region: DUF465; cl01070 765962003107 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003108 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 765962003109 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765962003110 dimer interface [polypeptide binding]; other site 765962003111 ssDNA binding site [nucleotide binding]; other site 765962003112 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765962003113 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 765962003114 DNA polymerase III subunit delta; Validated; Region: PRK08487 765962003115 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 765962003116 RNB domain; Region: RNB; pfam00773 765962003117 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 765962003118 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 765962003119 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 765962003120 shikimate binding site; other site 765962003121 NAD(P) binding site [chemical binding]; other site 765962003122 Bacterial SH3 domain; Region: SH3_3; cl02551 765962003123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765962003124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 765962003125 dimer interface [polypeptide binding]; other site 765962003126 conserved gate region; other site 765962003127 putative PBP binding loops; other site 765962003128 ABC-ATPase subunit interface; other site 765962003129 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 765962003130 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 765962003131 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 765962003132 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 765962003133 active site 765962003134 HIGH motif; other site 765962003135 dimer interface [polypeptide binding]; other site 765962003136 KMSKS motif; other site 765962003137 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 765962003138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003139 Preprotein translocase SecG subunit; Region: SecG; cl09123 765962003140 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 765962003141 hinge region; other site 765962003142 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 765962003143 RDD family; Region: RDD; cl00746 765962003144 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 765962003145 NAD+ binding site [chemical binding]; other site 765962003146 substrate binding site [chemical binding]; other site 765962003147 Zn binding site [ion binding]; other site 765962003148 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 765962003149 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 765962003150 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 765962003151 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 765962003152 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 765962003153 NADH dehydrogenase subunit G; Validated; Region: PRK08493 765962003154 NADH dehydrogenase subunit G; Validated; Region: PRK08493 765962003155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765962003156 catalytic loop [active] 765962003157 iron binding site [ion binding]; other site 765962003158 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 765962003159 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 765962003160 molybdopterin cofactor binding site; other site 765962003161 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 765962003162 NADH dehydrogenase; Region: NADHdh; cl00469 765962003163 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 765962003164 4Fe-4S binding domain; Region: Fer4; cl02805 765962003165 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 765962003166 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 765962003167 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 765962003168 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 765962003169 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 765962003170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765962003171 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 765962003172 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765962003173 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 765962003174 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765962003175 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 765962003176 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 765962003177 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 765962003178 active site 765962003179 substrate binding site [chemical binding]; other site 765962003180 metal binding site [ion binding]; metal-binding site 765962003181 Uncharacterized conserved protein [Function unknown]; Region: COG4278 765962003182 Thiamine pyrophosphokinase; Region: TPK; cl09135 765962003183 thiamine binding site [chemical binding]; other site 765962003184 tryptophan synthase; Region: PLN02591 765962003185 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 765962003186 substrate binding site [chemical binding]; other site 765962003187 active site 765962003188 catalytic residues [active] 765962003189 heterodimer interface [polypeptide binding]; other site 765962003190 tryptophan synthase, beta chain; Region: PLN02618 765962003191 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 765962003192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765962003193 catalytic residue [active] 765962003194 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 765962003195 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 765962003196 active site 765962003197 ribulose/triose binding site [chemical binding]; other site 765962003198 phosphate binding site [ion binding]; other site 765962003199 substrate (anthranilate) binding pocket [chemical binding]; other site 765962003200 product (indole) binding pocket [chemical binding]; other site 765962003201 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 765962003202 active site 765962003203 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 765962003204 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 765962003205 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 765962003206 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 765962003207 Glutamine amidotransferase class-I; Region: GATase; pfam00117 765962003208 glutamine binding [chemical binding]; other site 765962003209 catalytic triad [active] 765962003210 anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565 765962003211 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 765962003212 chorismate binding enzyme; Region: Chorismate_bind; cl10555 765962003213 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 765962003214 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765962003215 putative active site [active] 765962003216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 765962003217 active site 765962003218 motif I; other site 765962003219 motif II; other site 765962003220 YceI-like domain; Region: YceI; cl01001 765962003221 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 765962003222 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 765962003223 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 765962003224 Thiamine pyrophosphokinase; Region: TPK; cd07995 765962003225 active site 765962003226 dimerization interface [polypeptide binding]; other site 765962003227 thiamine binding site [chemical binding]; other site 765962003228 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 765962003229 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 765962003230 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 765962003231 alphaNTD homodimer interface [polypeptide binding]; other site 765962003232 alphaNTD - beta interaction site [polypeptide binding]; other site 765962003233 alphaNTD - beta' interaction site [polypeptide binding]; other site 765962003234 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 765962003235 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 765962003236 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 765962003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765962003238 RNA binding surface [nucleotide binding]; other site 765962003239 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 765962003240 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 765962003241 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 765962003242 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 765962003243 rRNA binding site [nucleotide binding]; other site 765962003244 predicted 30S ribosome binding site; other site 765962003245 methionine aminopeptidase; Reviewed; Region: PRK07281 765962003246 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 765962003247 active site 765962003248 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 765962003249 SecY translocase; Region: SecY; pfam00344 765962003250 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 765962003251 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 765962003252 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 765962003253 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 765962003254 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 765962003255 23S rRNA interface [nucleotide binding]; other site 765962003256 5S rRNA interface [nucleotide binding]; other site 765962003257 L27 interface [polypeptide binding]; other site 765962003258 L5 interface [polypeptide binding]; other site 765962003259 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 765962003260 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765962003261 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 765962003262 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 765962003263 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 765962003264 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 765962003265 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 765962003266 KOW motif; Region: KOW; cl00354 765962003267 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 765962003268 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 765962003269 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 765962003270 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 765962003271 23S rRNA interface [nucleotide binding]; other site 765962003272 5S rRNA interface [nucleotide binding]; other site 765962003273 putative antibiotic binding site [chemical binding]; other site 765962003274 L25 interface [polypeptide binding]; other site 765962003275 L27 interface [polypeptide binding]; other site 765962003276 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 765962003277 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 765962003278 G-X-X-G motif; other site 765962003279 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 765962003280 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 765962003281 putative translocon binding site; other site 765962003282 protein-rRNA interface [nucleotide binding]; other site 765962003283 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 765962003284 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 765962003285 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 765962003286 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 765962003287 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 765962003288 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 765962003289 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 765962003290 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 765962003291 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 765962003292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962003293 Walker A/P-loop; other site 765962003294 ATP binding site [chemical binding]; other site 765962003295 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 765962003296 RNA/DNA hybrid binding site [nucleotide binding]; other site 765962003297 active site 765962003298 fumarate hydratase; Reviewed; Region: fumC; PRK00485 765962003299 Class II fumarases; Region: Fumarase_classII; cd01362 765962003300 active site 765962003301 tetramer interface [polypeptide binding]; other site 765962003302 Outer membrane efflux protein; Region: OEP; pfam02321 765962003303 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 765962003304 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 765962003305 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 765962003306 AzlC protein; Region: AzlC; cl00570 765962003307 chaperone protein DnaJ; Provisional; Region: PRK14288 765962003308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 765962003309 HSP70 interaction site [polypeptide binding]; other site 765962003310 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 765962003311 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 765962003312 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 765962003313 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 765962003314 Ligand Binding Site [chemical binding]; other site 765962003315 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 765962003316 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 765962003317 active site 765962003318 (T/H)XGH motif; other site 765962003319 nickel responsive regulator; Provisional; Region: PRK00630 765962003320 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 765962003321 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765962003322 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 765962003323 Gram-negative bacterial tonB protein; Region: TonB; cl10048 765962003324 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003325 Integral membrane protein TerC family; Region: TerC; cl10468 765962003326 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 765962003327 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 765962003328 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 765962003329 substrate binding site [chemical binding]; other site 765962003330 hinge regions; other site 765962003331 ADP binding site [chemical binding]; other site 765962003332 catalytic site [active] 765962003333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962003334 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 765962003335 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765962003336 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 765962003337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765962003338 putative acyl-acceptor binding pocket; other site 765962003339 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 765962003340 C-terminal peptidase (prc); Region: prc; TIGR00225 765962003341 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 765962003342 protein binding site [polypeptide binding]; other site 765962003343 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 765962003344 Catalytic dyad [active] 765962003345 potential frameshift: common BLAST hit: gi|254779897|ref|YP_003058003.1| Type II restriction endonuclease 765962003346 potential frameshift: common BLAST hit: gi|108563725|ref|YP_628041.1| adenine specific DNA methyltransferase 765962003347 Predicted helicase [General function prediction only]; Region: COG4889 765962003348 Predicted helicase [General function prediction only]; Region: COG4889 765962003349 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 765962003350 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 765962003351 dimerization interface [polypeptide binding]; other site 765962003352 active site 765962003353 Quinolinate synthetase A protein; Region: NadA; cl00420 765962003354 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 765962003355 UbiA prenyltransferase family; Region: UbiA; cl00337 765962003356 Competence protein; Region: Competence; cl00471 765962003357 replicative DNA helicase; Provisional; Region: PRK08506 765962003358 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 765962003359 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 765962003360 Walker A motif; other site 765962003361 ATP binding site [chemical binding]; other site 765962003362 Walker B motif; other site 765962003363 DNA binding loops [nucleotide binding] 765962003364 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 765962003365 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 765962003366 putative ATP binding site [chemical binding]; other site 765962003367 putative substrate binding site [chemical binding]; other site 765962003368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 765962003369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765962003370 ATP binding site [chemical binding]; other site 765962003371 Mg2+ binding site [ion binding]; other site 765962003372 G-X-G motif; other site 765962003373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765962003374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 765962003375 active site 765962003376 phosphorylation site [posttranslational modification] 765962003377 intermolecular recognition site; other site 765962003378 dimerization interface [polypeptide binding]; other site 765962003379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 765962003380 DNA binding site [nucleotide binding] 765962003381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765962003383 Int/Topo IB signature motif; other site 765962003384 active site 765962003385 DNA binding site [nucleotide binding] 765962003386 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 765962003387 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 765962003388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962003389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962003390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962003391 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 765962003392 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 765962003393 active site 765962003394 metal binding site [ion binding]; metal-binding site 765962003395 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 765962003396 domain I; other site 765962003397 DNA binding groove [nucleotide binding] 765962003398 phosphate binding site [ion binding]; other site 765962003399 domain II; other site 765962003400 domain III; other site 765962003401 nucleotide binding site [chemical binding]; other site 765962003402 catalytic site [active] 765962003403 domain IV; other site 765962003404 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 765962003405 ParA-like protein; Provisional; Region: PHA02518 765962003406 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 765962003407 P-loop; other site 765962003408 Magnesium ion binding site [ion binding]; other site 765962003409 V-type ATP synthase subunit I; Validated; Region: PRK05771 765962003410 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 765962003411 HipA-like C-terminal domain; Region: HipA_C; pfam07804 765962003412 Fic family protein [Function unknown]; Region: COG3177 765962003413 Fic/DOC family; Region: Fic; cl00960 765962003414 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 765962003415 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765962003416 DNA binding site [nucleotide binding] 765962003417 Int/Topo IB signature motif; other site 765962003418 active site 765962003419 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 765962003420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962003421 Walker A motif; other site 765962003422 ATP binding site [chemical binding]; other site 765962003423 Walker B motif; other site 765962003424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003425 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 765962003426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003427 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765962003428 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 765962003429 rod shape-determining protein MreC; Region: MreC; pfam04085 765962003430 rod shape-determining protein MreB; Provisional; Region: PRK13927 765962003431 Cell division protein FtsA; Region: FtsA; cl11496 765962003432 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 765962003433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962003434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962003435 Walker A motif; other site 765962003436 ATP binding site [chemical binding]; other site 765962003437 Walker B motif; other site 765962003438 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 765962003439 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852 765962003440 active site 765962003441 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 765962003442 FliW protein; Region: FliW; cl00740 765962003443 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 765962003444 ATP-dependent protease La; Region: lon; TIGR00763 765962003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962003446 Walker A motif; other site 765962003447 ATP binding site [chemical binding]; other site 765962003448 Walker B motif; other site 765962003449 arginine finger; other site 765962003450 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 765962003451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962003452 Prephenate dehydrogenase; Region: PDH; pfam02153 765962003453 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 765962003454 active site 765962003455 substrate binding site [chemical binding]; other site 765962003456 Mg2+ binding site [ion binding]; other site 765962003457 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 765962003458 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 765962003459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 765962003462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 765962003463 biotin synthase; Provisional; Region: PRK08508 765962003464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 765962003465 FeS/SAM binding site; other site 765962003466 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 765962003467 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 765962003468 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765962003469 Domain of unknown function DUF143; Region: DUF143; cl00519 765962003470 IPP transferase; Region: IPPT; cl00403 765962003471 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 765962003472 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 765962003473 Ligand binding site [chemical binding]; other site 765962003474 metal binding site [ion binding]; metal-binding site 765962003475 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 765962003476 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 765962003477 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 765962003478 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 765962003479 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 765962003480 Walker A motif/ATP binding site; other site 765962003481 Walker B motif; other site 765962003482 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 765962003483 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 765962003484 ATP binding site [chemical binding]; other site 765962003485 Walker A motif; other site 765962003486 hexamer interface [polypeptide binding]; other site 765962003487 Walker B motif; other site 765962003488 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 765962003489 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765962003490 active site 765962003491 HIGH motif; other site 765962003492 nucleotide binding site [chemical binding]; other site 765962003493 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765962003494 active site 765962003495 KMSKS motif; other site 765962003496 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 765962003497 tRNA binding surface [nucleotide binding]; other site 765962003498 anticodon binding site; other site 765962003499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 765962003500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 765962003501 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 765962003502 KpsF/GutQ family protein; Region: kpsF; TIGR00393 765962003503 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 765962003504 putative active site [active] 765962003505 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 765962003506 conserved hypothetical protein; Region: MG423; TIGR00649 765962003507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765962003508 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 765962003509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003510 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 765962003511 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 765962003512 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 765962003513 active site 765962003514 substrate binding site [chemical binding]; other site 765962003515 cosubstrate binding site; other site 765962003516 catalytic site [active] 765962003517 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 765962003518 tandem repeat interface [polypeptide binding]; other site 765962003519 oligomer interface [polypeptide binding]; other site 765962003520 active site residues [active] 765962003521 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 765962003522 active site 765962003523 Global regulator protein family; Region: CsrA; cl00670 765962003524 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 765962003525 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 765962003526 SmpB-tmRNA interface; other site 765962003527 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765962003528 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 765962003529 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 765962003530 Ribonuclease P; Region: Ribonuclease_P; cl00457 765962003531 Domain of unknown function DUF37; Region: DUF37; cl00506 765962003532 membrane protein insertase; Provisional; Region: PRK01318 765962003533 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 765962003534 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 765962003535 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 765962003536 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 765962003537 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 765962003538 GTP/Mg2+ binding site [chemical binding]; other site 765962003539 G4 box; other site 765962003540 G5 box; other site 765962003541 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 765962003542 G1 box; other site 765962003543 G1 box; other site 765962003544 GTP/Mg2+ binding site [chemical binding]; other site 765962003545 Switch I region; other site 765962003546 Switch I region; other site 765962003547 G2 box; other site 765962003548 G2 box; other site 765962003549 Switch II region; other site 765962003550 G3 box; other site 765962003551 G3 box; other site 765962003552 Switch II region; other site 765962003553 G4 box; other site 765962003554 G5 box; other site 765962003555 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 765962003556 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003557 LPP20 lipoprotein precursor; Region: LPP20; pfam02169 765962003558 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 765962003559 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765962003560 catalytic residues [active] 765962003561 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 765962003562 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 765962003563 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 765962003564 active site 765962003565 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 765962003566 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 765962003567 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 765962003568 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 765962003569 generic binding surface I; other site 765962003570 generic binding surface II; other site 765962003571 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 765962003572 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 765962003573 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 765962003574 cofactor binding site; other site 765962003575 DNA binding site [nucleotide binding] 765962003576 substrate interaction site [chemical binding]; other site 765962003577 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 765962003578 cofactor binding site; other site 765962003579 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 765962003580 DNA binding site [nucleotide binding] 765962003581 substrate interaction site [chemical binding]; other site 765962003582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 765962003583 META domain; Region: META; cl01245 765962003584 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 765962003585 mce related protein; Region: MCE; cl03606 765962003586 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 765962003587 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 765962003588 Walker A/P-loop; other site 765962003589 ATP binding site [chemical binding]; other site 765962003590 Q-loop/lid; other site 765962003591 ABC transporter signature motif; other site 765962003592 Walker B; other site 765962003593 D-loop; other site 765962003594 H-loop/switch region; other site 765962003595 Domain of unknown function DUF140; Region: DUF140; cl00510 765962003596 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003597 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 765962003598 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 765962003599 homodimer interface [polypeptide binding]; other site 765962003600 substrate-cofactor binding pocket; other site 765962003601 catalytic residue [active] 765962003602 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003603 DNA polymerase I; Region: pola; TIGR00593 765962003604 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 765962003605 active site 765962003606 metal binding site 1 [ion binding]; metal-binding site 765962003607 putative 5' ssDNA interaction site; other site 765962003608 metal binding site 3; metal-binding site 765962003609 metal binding site 2 [ion binding]; metal-binding site 765962003610 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 765962003611 putative DNA binding site [nucleotide binding]; other site 765962003612 putative metal binding site [ion binding]; other site 765962003613 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 765962003614 active site 765962003615 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 765962003616 active site 765962003617 DNA binding site [nucleotide binding] 765962003618 catalytic site [active] 765962003619 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962003620 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962003621 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 765962003622 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 765962003623 thymidylate kinase; Validated; Region: tmk; PRK00698 765962003624 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 765962003625 TMP-binding site; other site 765962003626 ATP-binding site [chemical binding]; other site 765962003627 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 765962003628 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 765962003629 active site 765962003630 (T/H)XGH motif; other site 765962003631 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 765962003632 Flavoprotein; Region: Flavoprotein; cl08021 765962003633 SAF domain; Region: SAF; cl00555 765962003634 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 765962003635 UvrD/REP helicase; Region: UvrD-helicase; cl14126 765962003636 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765962003637 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765962003638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 765962003639 TPR motif; other site 765962003640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 765962003641 binding surface 765962003642 TPR motif; other site 765962003643 seryl-tRNA synthetase; Provisional; Region: PRK05431 765962003644 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 765962003645 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 765962003646 dimer interface [polypeptide binding]; other site 765962003647 active site 765962003648 motif 1; other site 765962003649 motif 2; other site 765962003650 motif 3; other site 765962003651 Predicted amidohydrolase [General function prediction only]; Region: COG0388 765962003652 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 765962003653 active site 765962003654 catalytic triad [active] 765962003655 dimer interface [polypeptide binding]; other site 765962003656 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14065 765962003657 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 765962003658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962003659 S-adenosylmethionine binding site [chemical binding]; other site 765962003660 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 765962003661 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 765962003662 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 765962003663 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 765962003664 Predicted membrane protein [Function unknown]; Region: COG1511 765962003665 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 765962003666 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 765962003667 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765962003668 Outer membrane efflux protein; Region: OEP; pfam02321 765962003669 Outer membrane efflux protein; Region: OEP; pfam02321 765962003670 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765962003671 Domain of unknown function DUF21; Region: DUF21; pfam01595 765962003672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765962003673 Transporter associated domain; Region: CorC_HlyC; pfam03471 765962003674 Phosphate transporter family; Region: PHO4; cl00396 765962003675 Phosphate transporter family; Region: PHO4; cl00396 765962003676 NifU-like domain; Region: NifU; cl00484 765962003677 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 765962003678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765962003679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765962003680 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 765962003681 putative active site [active] 765962003682 transaldolase; Provisional; Region: PRK03903 765962003683 catalytic residue [active] 765962003684 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 765962003685 5S rRNA interface [nucleotide binding]; other site 765962003686 CTC domain interface; other site 765962003687 L16 interface [polypeptide binding]; other site 765962003688 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 765962003689 putative active site [active] 765962003690 catalytic residue [active] 765962003691 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 765962003692 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 765962003693 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 765962003694 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 765962003695 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 765962003696 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 765962003697 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 765962003699 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 765962003700 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765962003701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 765962003702 metal-binding site [ion binding] 765962003703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765962003704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962003705 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 765962003706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 765962003707 S-adenosylmethionine binding site [chemical binding]; other site 765962003708 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 765962003709 catalytic motif [active] 765962003710 Zn binding site [ion binding]; other site 765962003711 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 765962003712 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 765962003713 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 765962003714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765962003715 NAD(P) binding pocket [chemical binding]; other site 765962003716 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 765962003717 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 765962003718 Domain of unknown function (DUF205); Region: DUF205; cl00410 765962003719 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 765962003720 homooctamer interface [polypeptide binding]; other site 765962003721 active site 765962003722 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 765962003723 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 765962003724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765962003725 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 765962003726 NusA N-terminal domain; Region: NusA_N; pfam08529 765962003727 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 765962003728 RNA binding site [nucleotide binding]; other site 765962003729 homodimer interface [polypeptide binding]; other site 765962003730 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 765962003731 G-X-X-G motif; other site 765962003732 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 765962003733 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 765962003734 putative active site [active] 765962003735 putative NTP binding site [chemical binding]; other site 765962003736 putative nucleic acid binding site [nucleotide binding]; other site 765962003737 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 765962003738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003739 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 765962003740 potential frameshift: common BLAST hit: gi|254780027|ref|YP_003058134.1| Type III R-M system restriction enzyme 765962003741 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 765962003742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 765962003745 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 765962003746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962003747 ATP binding site [chemical binding]; other site 765962003748 putative Mg++ binding site [ion binding]; other site 765962003749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962003750 nucleotide binding region [chemical binding]; other site 765962003751 ATP-binding site [chemical binding]; other site 765962003752 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003753 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 765962003754 active site 765962003755 DNA binding site [nucleotide binding] 765962003756 putative phosphate binding site [ion binding]; other site 765962003757 putative catalytic site [active] 765962003758 metal binding site A [ion binding]; metal-binding site 765962003759 AP binding site [nucleotide binding]; other site 765962003760 metal binding site B [ion binding]; metal-binding site 765962003761 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 765962003762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 765962003763 Walker A motif; other site 765962003764 ATP binding site [chemical binding]; other site 765962003765 Walker B motif; other site 765962003766 arginine finger; other site 765962003767 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765962003768 DnaA box-binding interface [nucleotide binding]; other site 765962003769 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 765962003770 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 765962003771 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 765962003772 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 765962003773 glutaminase active site [active] 765962003774 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 765962003775 dimer interface [polypeptide binding]; other site 765962003776 active site 765962003777 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 765962003778 dimer interface [polypeptide binding]; other site 765962003779 active site 765962003780 Thymidylate synthase complementing protein; Region: Thy1; cl03630 765962003781 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962003782 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 765962003783 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 765962003784 potential frameshift: common BLAST hit: gi|254780040|ref|YP_003058147.1| Type I restriction-modification enzyme subunit M 765962003785 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 765962003786 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 765962003787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962003788 ATP binding site [chemical binding]; other site 765962003789 putative Mg++ binding site [ion binding]; other site 765962003790 Protein of unknown function DUF45; Region: DUF45; cl00636 765962003791 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 765962003792 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 765962003793 N-terminal plug; other site 765962003794 ligand-binding site [chemical binding]; other site 765962003795 Arginase family; Region: Arginase; cl00306 765962003796 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 765962003797 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 765962003798 Protein of unknown function DUF262; Region: DUF262; cl14890 765962003799 Protein of unknown function DUF262; Region: DUF262; cl14890 765962003800 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 765962003801 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 765962003802 ATP-NAD kinase; Region: NAD_kinase; pfam01513 765962003803 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 765962003804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 765962003805 Walker A/P-loop; other site 765962003806 ATP binding site [chemical binding]; other site 765962003807 Q-loop/lid; other site 765962003808 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 765962003809 ABC transporter signature motif; other site 765962003810 Walker B; other site 765962003811 D-loop; other site 765962003812 H-loop/switch region; other site 765962003813 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 765962003814 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 765962003815 Domain of unknown function (DUF814); Region: DUF814; pfam05670 765962003816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 765962003817 Probable transposase; Region: OrfB_IS605; pfam01385 765962003818 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 765962003819 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 765962003820 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 765962003821 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765962003822 active site 765962003823 substrate binding site [chemical binding]; other site 765962003824 catalytic site [active] 765962003825 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 765962003826 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 765962003827 substrate binding site [chemical binding]; other site 765962003828 hexamer interface [polypeptide binding]; other site 765962003829 metal binding site [ion binding]; metal-binding site 765962003830 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 765962003831 active site 765962003832 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 765962003833 Cytochrome c; Region: Cytochrom_C; cl11414 765962003834 Cytochrome c; Region: Cytochrom_C; cl11414 765962003835 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 765962003836 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 765962003837 intrachain domain interface; other site 765962003838 interchain domain interface [polypeptide binding]; other site 765962003839 heme bH binding site [chemical binding]; other site 765962003840 Qi binding site; other site 765962003841 heme bL binding site [chemical binding]; other site 765962003842 Qo binding site; other site 765962003843 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 765962003844 interchain domain interface [polypeptide binding]; other site 765962003845 intrachain domain interface; other site 765962003846 Qi binding site; other site 765962003847 Qo binding site; other site 765962003848 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 765962003849 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 765962003850 [2Fe-2S] cluster binding site [ion binding]; other site 765962003851 transcription-repair coupling factor; Region: mfd; TIGR00580 765962003852 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 765962003853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765962003854 ATP binding site [chemical binding]; other site 765962003855 putative Mg++ binding site [ion binding]; other site 765962003856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765962003857 nucleotide binding region [chemical binding]; other site 765962003858 ATP-binding site [chemical binding]; other site 765962003859 TRCF domain; Region: TRCF; pfam03461 765962003860 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 765962003861 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765962003862 Peptidase family M23; Region: Peptidase_M23; pfam01551 765962003863 Peptidase family M23; Region: Peptidase_M23; pfam01551 765962003864 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 765962003865 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765962003866 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 765962003867 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 765962003868 HIGH motif; other site 765962003869 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 765962003870 active site 765962003871 KMSKS motif; other site 765962003872 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 765962003873 tRNA binding surface [nucleotide binding]; other site 765962003874 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 765962003875 Protein export membrane protein; Region: SecD_SecF; cl14618 765962003876 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 765962003877 Protein export membrane protein; Region: SecD_SecF; cl14618 765962003878 Preprotein translocase subunit; Region: YajC; cl00806 765962003879 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 765962003880 putative recombination protein RecB; Provisional; Region: PRK13909 765962003881 UvrD/REP helicase; Region: UvrD-helicase; cl14126 765962003882 UvrD/REP helicase; Region: UvrD-helicase; cl14126 765962003883 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 765962003884 rRNA interaction site [nucleotide binding]; other site 765962003885 S8 interaction site; other site 765962003886 putative laminin-1 binding site; other site 765962003887 elongation factor Ts; Provisional; Region: tsf; PRK09377 765962003888 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 765962003889 Elongation factor TS; Region: EF_TS; pfam00889 765962003890 Elongation factor TS; Region: EF_TS; pfam00889 765962003891 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 765962003892 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765962003893 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 765962003894 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 765962003895 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 765962003896 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 765962003897 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 765962003898 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 765962003899 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 765962003900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 765962003901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 765962003902 intersubunit interface [polypeptide binding]; other site 765962003903 peroxidase; Provisional; Region: PRK15000 765962003904 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 765962003905 dimer interface [polypeptide binding]; other site 765962003906 decamer (pentamer of dimers) interface [polypeptide binding]; other site 765962003907 catalytic triad [active] 765962003908 peroxidatic and resolving cysteines [active] 765962003909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765962003910 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 765962003911 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765962003912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 765962003913 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 765962003914 G1 box; other site 765962003915 GTP/Mg2+ binding site [chemical binding]; other site 765962003916 Switch I region; other site 765962003917 G2 box; other site 765962003918 G3 box; other site 765962003919 Switch II region; other site 765962003920 G4 box; other site 765962003921 G5 box; other site 765962003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 765962003923 OstA-like protein; Region: OstA; cl00844 765962003924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 765962003925 rare lipoprotein A; Region: rlpA; TIGR00413 765962003926 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 765962003927 Sporulation related domain; Region: SPOR; cl10051 765962003928 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 765962003929 N-acetyl-D-glucosamine binding site [chemical binding]; other site 765962003930 catalytic residue [active] 765962003931 autolysin; Reviewed; Region: PRK06347 765962003932 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 765962003933 putative peptidoglycan binding site; other site 765962003934 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 765962003935 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 765962003936 active site 765962003937 riboflavin synthase, alpha subunit; Region: ribE; TIGR00187 765962003938 Lumazine binding domain; Region: Lum_binding; pfam00677 765962003939 Lumazine binding domain; Region: Lum_binding; pfam00677 765962003940 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 765962003941 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 765962003942 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 765962003943 Walker A/P-loop; other site 765962003944 ATP binding site [chemical binding]; other site 765962003945 Q-loop/lid; other site 765962003946 ABC transporter signature motif; other site 765962003947 Walker B; other site 765962003948 D-loop; other site 765962003949 H-loop/switch region; other site 765962003950 NIL domain; Region: NIL; pfam09383 765962003951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 765962003952 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 765962003953 active site 765962003954 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 765962003955 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases...; Region: GT_MraY_like; cd06912 765962003956 Mg++ binding site [ion binding]; other site 765962003957 putative catalytic motif [active] 765962003958 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 765962003959 active site 765962003960 hydrophilic channel; other site 765962003961 dimerization interface [polypeptide binding]; other site 765962003962 catalytic residues [active] 765962003963 active site lid [active] 765962003964 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 765962003965 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 765962003966 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 765962003967 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 765962003968 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 765962003969 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 765962003970 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 765962003971 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 765962003972 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045