-- dump date   	20120504_150529
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
608538000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
608538000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000003	Walker A motif; other site
608538000004	ATP binding site [chemical binding]; other site
608538000005	Walker B motif; other site
608538000006	arginine finger; other site
608538000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
608538000008	DnaA box-binding interface [nucleotide binding]; other site
608538000009	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
608538000010	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
608538000011	classical (c) SDRs; Region: SDR_c; cd05233
608538000012	short chain dehydrogenase; Provisional; Region: PRK06924
608538000013	NAD(P) binding site [chemical binding]; other site
608538000014	active site
608538000015	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
608538000016	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
608538000017	putative active site [active]
608538000018	metal binding site [ion binding]; metal-binding site
608538000019	homodimer binding site [polypeptide binding]; other site
608538000020	aromatic acid decarboxylase; Validated; Region: PRK05920
608538000021	Flavoprotein; Region: Flavoprotein; cl08021
608538000022	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
608538000023	Na binding site [ion binding]; other site
608538000024	putative glycosylation site [posttranslational modification]; other site
608538000025	putative glycosylation site [posttranslational modification]; other site
608538000026	aspartate aminotransferase; Provisional; Region: PRK05764
608538000027	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538000028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538000029	homodimer interface [polypeptide binding]; other site
608538000030	catalytic residue [active]
608538000031	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
608538000032	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
608538000033	NAD binding site [chemical binding]; other site
608538000034	homotetramer interface [polypeptide binding]; other site
608538000035	homodimer interface [polypeptide binding]; other site
608538000036	substrate binding site [chemical binding]; other site
608538000037	active site
608538000038	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
608538000039	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
608538000040	putative active site; other site
608538000041	catalytic residue [active]
608538000042	Gram-negative bacterial tonB protein; Region: TonB; cl10048
608538000043	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000044	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
608538000045	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
608538000046	active site
608538000047	substrate binding site [chemical binding]; other site
608538000048	metal binding site [ion binding]; metal-binding site
608538000049	Protein of unknown function DUF45; Region: DUF45; cl00636
608538000050	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
608538000051	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
608538000052	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538000054	ATP binding site [chemical binding]; other site
608538000055	putative Mg++ binding site [ion binding]; other site
608538000056	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
608538000057	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538000058	active site
608538000059	NTP binding site [chemical binding]; other site
608538000060	metal binding triad [ion binding]; metal-binding site
608538000061	antibiotic binding site [chemical binding]; other site
608538000062	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
608538000063	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
608538000064	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
608538000065	HsdM N-terminal domain; Region: HsdM_N; pfam12161
608538000066	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
608538000067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538000068	MoxR-like ATPases [General function prediction only]; Region: COG0714
608538000069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000070	Walker A motif; other site
608538000071	ATP binding site [chemical binding]; other site
608538000072	Walker B motif; other site
608538000073	arginine finger; other site
608538000074	ribosome maturation protein RimP; Reviewed; Region: PRK00092
608538000075	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
608538000076	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
608538000077	Sm1 motif; other site
608538000078	D1 - D2 interaction site; other site
608538000079	D3 - B interaction site; other site
608538000080	Hfq - Hfq interaction site; other site
608538000081	RNA binding pocket [nucleotide binding]; other site
608538000082	Sm2 motif; other site
608538000083	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
608538000084	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
608538000085	RNA binding site [nucleotide binding]; other site
608538000086	homodimer interface [polypeptide binding]; other site
608538000087	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
608538000088	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
608538000089	G-X-X-G motif; other site
608538000090	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
608538000091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000092	S-adenosylmethionine binding site [chemical binding]; other site
608538000093	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
608538000094	ATP cone domain; Region: ATP-cone; pfam03477
608538000095	Class I ribonucleotide reductase; Region: RNR_I; cd01679
608538000096	active site
608538000097	dimer interface [polypeptide binding]; other site
608538000098	catalytic residues [active]
608538000099	effector binding site; other site
608538000100	R2 peptide binding site; other site
608538000101	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
608538000102	dimer interface [polypeptide binding]; other site
608538000103	putative radical transfer pathway; other site
608538000104	diiron center [ion binding]; other site
608538000105	tyrosyl radical; other site
608538000106	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
608538000107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000108	putative substrate translocation pore; other site
608538000109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000110	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
608538000111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000112	putative substrate translocation pore; other site
608538000113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000114	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
608538000115	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538000116	FlxA-like protein; Region: FlxA; pfam14282
608538000117	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538000118	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538000119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538000120	Helix-turn-helix domains; Region: HTH; cl00088
608538000121	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538000122	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538000123	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538000124	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538000125	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
608538000126	Protein export membrane protein; Region: SecD_SecF; cl14618
608538000127	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
608538000128	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538000129	minor groove reading motif; other site
608538000130	helix-hairpin-helix signature motif; other site
608538000131	substrate binding pocket [chemical binding]; other site
608538000132	active site
608538000133	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
608538000134	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538000135	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538000136	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
608538000137	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
608538000138	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
608538000139	putative catalytic cysteine [active]
608538000140	glycogen branching enzyme; Provisional; Region: PRK12313
608538000141	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
608538000142	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
608538000143	active site
608538000144	catalytic site [active]
608538000145	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
608538000146	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
608538000147	MutS domain I; Region: MutS_I; pfam01624
608538000148	MutS domain II; Region: MutS_II; pfam05188
608538000149	MutS family domain IV; Region: MutS_IV; pfam05190
608538000150	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000151	Walker A/P-loop; other site
608538000152	ATP binding site [chemical binding]; other site
608538000153	Q-loop/lid; other site
608538000154	ABC transporter signature motif; other site
608538000155	Walker B; other site
608538000156	D-loop; other site
608538000157	H-loop/switch region; other site
608538000158	phosphodiesterase; Provisional; Region: PRK12704
608538000159	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
608538000160	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
608538000161	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
608538000162	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
608538000163	putative tRNA-binding site [nucleotide binding]; other site
608538000164	B3/4 domain; Region: B3_4; cl11458
608538000165	tRNA synthetase B5 domain; Region: B5; cl08394
608538000166	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
608538000167	dimer interface [polypeptide binding]; other site
608538000168	motif 1; other site
608538000169	motif 3; other site
608538000170	motif 2; other site
608538000171	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
608538000172	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000173	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
608538000174	Walker A/P-loop; other site
608538000175	ATP binding site [chemical binding]; other site
608538000176	Q-loop/lid; other site
608538000177	ABC transporter signature motif; other site
608538000178	Walker B; other site
608538000179	D-loop; other site
608538000180	H-loop/switch region; other site
608538000181	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
608538000182	ABC-2 type transporter; Region: ABC2_membrane; cl11417
608538000183	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
608538000184	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
608538000185	intersubunit interface [polypeptide binding]; other site
608538000186	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
608538000187	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
608538000188	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
608538000189	ABC-ATPase subunit  interface; other site
608538000190	dimer interface [polypeptide binding]; other site
608538000191	putative PBP binding regions; other site
608538000192	ribonuclease HIII; Region: rnhC; TIGR00716
608538000193	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
608538000194	RNA/DNA hybrid binding site [nucleotide binding]; other site
608538000195	active site
608538000196	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
608538000197	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
608538000198	GAF domain; Region: GAF; cl15785
608538000199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000200	Walker A motif; other site
608538000201	ATP binding site [chemical binding]; other site
608538000202	Walker B motif; other site
608538000203	arginine finger; other site
608538000204	Helix-turn-helix domains; Region: HTH; cl00088
608538000205	AIR carboxylase; Region: AIRC; cl00310
608538000206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538000207	PAS fold; Region: PAS_3; pfam08447
608538000208	putative active site [active]
608538000209	heme pocket [chemical binding]; other site
608538000210	PAS domain S-box; Region: sensory_box; TIGR00229
608538000211	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538000212	putative active site [active]
608538000213	heme pocket [chemical binding]; other site
608538000214	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
608538000215	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538000216	metal binding site [ion binding]; metal-binding site
608538000217	active site
608538000218	I-site; other site
608538000219	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
608538000220	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
608538000221	apolar tunnel; other site
608538000222	heme binding site [chemical binding]; other site
608538000223	dimerization interface [polypeptide binding]; other site
608538000224	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
608538000225	heme-binding site [chemical binding]; other site
608538000226	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538000227	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538000228	intracellular protease, PfpI family; Region: PfpI; TIGR01382
608538000229	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
608538000230	conserved cys residue [active]
608538000231	PUA domain; Region: PUA; cl00607
608538000232	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
608538000233	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
608538000234	putative RNA binding site [nucleotide binding]; other site
608538000235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000236	S-adenosylmethionine binding site [chemical binding]; other site
608538000237	Bacitracin resistance protein BacA; Region: BacA; cl00858
608538000238	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
608538000239	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
608538000240	shikimate kinase; Reviewed; Region: aroK; PRK00131
608538000241	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
608538000242	ADP binding site [chemical binding]; other site
608538000243	magnesium binding site [ion binding]; other site
608538000244	putative shikimate binding site; other site
608538000245	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
608538000246	active site
608538000247	multimer interface [polypeptide binding]; other site
608538000248	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
608538000249	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
608538000250	FAD binding pocket [chemical binding]; other site
608538000251	conserved FAD binding motif [chemical binding]; other site
608538000252	phosphate binding motif [ion binding]; other site
608538000253	beta-alpha-beta structure motif; other site
608538000254	NAD binding pocket [chemical binding]; other site
608538000255	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
608538000256	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
608538000257	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
608538000258	Quinolinate synthetase A protein; Region: NadA; cl00420
608538000259	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
608538000260	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
608538000261	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
608538000262	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000263	Peptidase family M48; Region: Peptidase_M48; cl12018
608538000264	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
608538000265	proposed catalytic triad [active]
608538000266	conserved cys residue [active]
608538000267	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
608538000268	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
608538000269	NAD(P) binding site [chemical binding]; other site
608538000270	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538000271	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538000272	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
608538000273	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
608538000274	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
608538000275	glutamine binding [chemical binding]; other site
608538000276	catalytic triad [active]
608538000277	acetyl-CoA synthetase; Provisional; Region: PRK00174
608538000278	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
608538000279	AMP-binding enzyme; Region: AMP-binding; cl15778
608538000280	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
608538000281	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
608538000282	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538000283	N-terminal plug; other site
608538000284	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
608538000285	ligand-binding site [chemical binding]; other site
608538000286	DsrE/DsrF-like family; Region: DrsE; cl00672
608538000287	diaminopimelate decarboxylase; Region: lysA; TIGR01048
608538000288	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
608538000289	active site
608538000290	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538000291	substrate binding site [chemical binding]; other site
608538000292	catalytic residues [active]
608538000293	dimer interface [polypeptide binding]; other site
608538000294	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538000295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000296	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
608538000297	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
608538000298	dimer interface [polypeptide binding]; other site
608538000299	active site
608538000300	Ferritin-like domain; Region: Ferritin; pfam00210
608538000301	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
608538000302	dinuclear metal binding motif [ion binding]; other site
608538000303	Ferritin-like domain; Region: Ferritin; pfam00210
608538000304	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
608538000305	dinuclear metal binding motif [ion binding]; other site
608538000306	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538000307	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
608538000308	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
608538000309	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538000310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000311	cation transport protein; Region: 2A0119; TIGR00898
608538000312	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
608538000313	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
608538000314	P loop; other site
608538000315	Nucleotide binding site [chemical binding]; other site
608538000316	DTAP/Switch II; other site
608538000317	Switch I; other site
608538000318	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538000319	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538000320	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
608538000321	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538000322	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
608538000323	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
608538000324	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
608538000325	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
608538000326	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538000327	inhibitor-cofactor binding pocket; inhibition site
608538000328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538000329	catalytic residue [active]
608538000330	Dehydratase family; Region: ILVD_EDD; cl00340
608538000331	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
608538000332	putative active site [active]
608538000333	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
608538000334	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
608538000335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
608538000336	Tetratricopeptide repeat; Region: TPR_6; pfam13174
608538000337	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
608538000338	catalytic core [active]
608538000339	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
608538000340	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538000341	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538000342	catalytic residue [active]
608538000343	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
608538000344	EamA-like transporter family; Region: EamA; cl01037
608538000345	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
608538000346	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
608538000347	trimer interface [polypeptide binding]; other site
608538000348	putative metal binding site [ion binding]; other site
608538000349	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
608538000350	Phosphoglycerate kinase; Region: PGK; pfam00162
608538000351	substrate binding site [chemical binding]; other site
608538000352	hinge regions; other site
608538000353	ADP binding site [chemical binding]; other site
608538000354	catalytic site [active]
608538000355	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
608538000356	active site
608538000357	ribulose/triose binding site [chemical binding]; other site
608538000358	phosphate binding site [ion binding]; other site
608538000359	substrate (anthranilate) binding pocket [chemical binding]; other site
608538000360	product (indole) binding pocket [chemical binding]; other site
608538000361	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538000362	CPxP  motif; other site
608538000363	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
608538000364	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
608538000365	Transglycosylase; Region: Transgly; cl07896
608538000366	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
608538000367	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611
608538000368	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
608538000369	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
608538000370	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
608538000371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538000372	active site
608538000373	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
608538000374	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
608538000375	5S rRNA interface [nucleotide binding]; other site
608538000376	CTC domain interface [polypeptide binding]; other site
608538000377	L16 interface [polypeptide binding]; other site
608538000378	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
608538000379	putative active site [active]
608538000380	catalytic residue [active]
608538000381	transketolase; Reviewed; Region: PRK05899
608538000382	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
608538000383	TPP-binding site [chemical binding]; other site
608538000384	dimer interface [polypeptide binding]; other site
608538000385	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
608538000386	PYR/PP interface [polypeptide binding]; other site
608538000387	dimer interface [polypeptide binding]; other site
608538000388	TPP binding site [chemical binding]; other site
608538000389	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538000390	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
608538000391	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538000392	catalytic loop [active]
608538000393	iron binding site [ion binding]; other site
608538000394	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
608538000395	4Fe-4S binding domain; Region: Fer4; cl02805
608538000396	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
608538000397	molybdopterin cofactor binding site; other site
608538000398	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
608538000399	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
608538000400	putative dimer interface [polypeptide binding]; other site
608538000401	[2Fe-2S] cluster binding site [ion binding]; other site
608538000402	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
608538000403	SLBB domain; Region: SLBB; pfam10531
608538000404	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
608538000405	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
608538000406	Fe-S cluster binding site [ion binding]; other site
608538000407	active site
608538000408	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
608538000409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000410	oligomerization interface [polypeptide binding]; other site
608538000411	active site
608538000412	NAD+ binding site [chemical binding]; other site
608538000413	Isochorismatase family; Region: Isochorismatase; pfam00857
608538000414	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
608538000415	catalytic triad [active]
608538000416	dimer interface [polypeptide binding]; other site
608538000417	conserved cis-peptide bond; other site
608538000418	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
608538000419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000420	S-adenosylmethionine binding site [chemical binding]; other site
608538000421	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000422	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
608538000423	putative acyl-acceptor binding pocket; other site
608538000424	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
608538000425	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
608538000426	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
608538000427	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
608538000428	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
608538000429	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
608538000430	DNA binding residues [nucleotide binding]
608538000431	putative dimer interface [polypeptide binding]; other site
608538000432	chaperone protein DnaJ; Provisional; Region: PRK14291
608538000433	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
608538000434	HSP70 interaction site [polypeptide binding]; other site
608538000435	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
608538000436	Zn binding sites [ion binding]; other site
608538000437	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
608538000438	dimer interface [polypeptide binding]; other site
608538000439	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
608538000440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000441	S-adenosylmethionine binding site [chemical binding]; other site
608538000442	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
608538000443	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
608538000444	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
608538000445	rod shape-determining protein MreC; Region: MreC; pfam04085
608538000446	rod shape-determining protein MreB; Provisional; Region: PRK13927
608538000447	Cell division protein FtsA; Region: FtsA; cl11496
608538000448	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
608538000449	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
608538000450	Zn2+ binding site [ion binding]; other site
608538000451	Mg2+ binding site [ion binding]; other site
608538000452	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
608538000453	synthetase active site [active]
608538000454	NTP binding site [chemical binding]; other site
608538000455	metal binding site [ion binding]; metal-binding site
608538000456	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
608538000457	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
608538000458	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
608538000459	formiminoglutamate deiminase; Region: hutF; TIGR02022
608538000460	active site
608538000461	putative substrate binding pocket [chemical binding]; other site
608538000462	dihydrodipicolinate reductase; Provisional; Region: PRK00048
608538000463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000464	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
608538000465	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
608538000466	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
608538000467	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538000468	nucleotide binding region [chemical binding]; other site
608538000469	ATP-binding site [chemical binding]; other site
608538000470	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
608538000471	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
608538000472	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000473	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
608538000474	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538000475	FeS/SAM binding site; other site
608538000476	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
608538000477	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538000478	Heme NO binding; Region: HNOB; cl15268
608538000479	Cytochrome c; Region: Cytochrom_C; cl11414
608538000480	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000481	Cytochrome c; Region: Cytochrom_C; cl11414
608538000482	Cytochrome c; Region: Cytochrom_C; cl11414
608538000483	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000484	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538000485	Cu(I) binding site [ion binding]; other site
608538000486	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
608538000487	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538000488	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538000489	Low-spin heme binding site [chemical binding]; other site
608538000490	D-pathway; other site
608538000491	Putative water exit pathway; other site
608538000492	Binuclear center (active site) [active]
608538000493	K-pathway; other site
608538000494	Putative proton exit pathway; other site
608538000495	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
608538000496	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538000497	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
608538000498	interchain domain interface [polypeptide binding]; other site
608538000499	intrachain domain interface; other site
608538000500	heme bH binding site [chemical binding]; other site
608538000501	Qi binding site; other site
608538000502	heme bL binding site [chemical binding]; other site
608538000503	Qo binding site; other site
608538000504	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
608538000505	4Fe-4S binding domain; Region: Fer4; cl02805
608538000506	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
608538000507	Cytochrome c; Region: Cytochrom_C; cl11414
608538000508	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
608538000509	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
608538000510	Walker A/P-loop; other site
608538000511	ATP binding site [chemical binding]; other site
608538000512	Q-loop/lid; other site
608538000513	ABC transporter signature motif; other site
608538000514	Walker B; other site
608538000515	D-loop; other site
608538000516	H-loop/switch region; other site
608538000517	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
608538000518	NosL; Region: NosL; cl01769
608538000519	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
608538000520	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538000521	Cytochrome c; Region: Cytochrom_C; cl11414
608538000522	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
608538000523	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
608538000524	catalytic site [active]
608538000525	G-X2-G-X-G-K; other site
608538000526	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
608538000527	Found in ATP-dependent protease La (LON); Region: LON; smart00464
608538000528	Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736
608538000529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000530	Walker A motif; other site
608538000531	ATP binding site [chemical binding]; other site
608538000532	Walker B motif; other site
608538000533	arginine finger; other site
608538000534	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
608538000535	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
608538000536	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000537	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
608538000538	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
608538000539	heme-binding site [chemical binding]; other site
608538000540	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000541	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
608538000542	Transcriptional regulator; Region: Transcrip_reg; cl00361
608538000543	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
608538000544	homotrimer interaction site [polypeptide binding]; other site
608538000545	putative active site [active]
608538000546	lysyl-tRNA synthetase; Region: PLN02502
608538000547	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
608538000548	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
608538000549	dimer interface [polypeptide binding]; other site
608538000550	putative anticodon binding site; other site
608538000551	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
608538000552	motif 1; other site
608538000553	active site
608538000554	motif 2; other site
608538000555	motif 3; other site
608538000556	ATP synthase; Region: ATP-synt; cl00365
608538000557	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
608538000558	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
608538000559	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
608538000560	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
608538000561	alpha subunit interaction interface [polypeptide binding]; other site
608538000562	Walker A motif; other site
608538000563	ATP binding site [chemical binding]; other site
608538000564	Walker B motif; other site
608538000565	inhibitor binding site; inhibition site
608538000566	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
608538000567	ribonuclease PH; Reviewed; Region: rph; PRK00173
608538000568	Ribonuclease PH; Region: RNase_PH_bact; cd11362
608538000569	hexamer interface [polypeptide binding]; other site
608538000570	active site
608538000571	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
608538000572	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
608538000573	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
608538000574	metal binding site [ion binding]; metal-binding site
608538000575	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
608538000576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000577	Walker A motif; other site
608538000578	ATP binding site [chemical binding]; other site
608538000579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000580	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
608538000581	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
608538000582	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
608538000583	catalytic core [active]
608538000584	Protein of unknown function (DUF429); Region: DUF429; cl12046
608538000585	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
608538000586	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
608538000587	Ligand Binding Site [chemical binding]; other site
608538000588	K+-transporting ATPase, c chain; Region: KdpC; cl00944
608538000589	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
608538000590	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538000591	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538000592	GYD domain; Region: GYD; cl01743
608538000593	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
608538000594	active site
608538000595	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
608538000596	3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093
608538000597	active site
608538000598	catalytic residue [active]
608538000599	dimer interface [polypeptide binding]; other site
608538000600	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
608538000601	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
608538000602	ANP binding site [chemical binding]; other site
608538000603	Substrate Binding Site II [chemical binding]; other site
608538000604	Substrate Binding Site I [chemical binding]; other site
608538000605	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
608538000606	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
608538000607	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
608538000608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000609	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
608538000610	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
608538000611	ThiC family; Region: ThiC; cl08031
608538000612	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000613	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
608538000614	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
608538000615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000616	CoA-ligase; Region: Ligase_CoA; cl02894
608538000617	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
608538000618	AMP-binding enzyme; Region: AMP-binding; cl15778
608538000619	Phosphopantetheine attachment site; Region: PP-binding; cl09936
608538000620	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
608538000621	putative acyl-acceptor binding pocket; other site
608538000622	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
608538000623	active site
608538000624	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000625	putative substrate translocation pore; other site
608538000626	Major Facilitator Superfamily; Region: MFS_1; pfam07690
608538000627	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
608538000628	substrate binding site; other site
608538000629	dimer interface; other site
608538000630	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
608538000631	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
608538000632	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
608538000633	Mg++ binding site [ion binding]; other site
608538000634	putative catalytic motif [active]
608538000635	putative substrate binding site [chemical binding]; other site
608538000636	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
608538000637	Helix-turn-helix domains; Region: HTH; cl00088
608538000638	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
608538000639	Rrf2 family protein; Region: rrf2_super; TIGR00738
608538000640	Helix-turn-helix domains; Region: HTH; cl00088
608538000641	ATP cone domain; Region: ATP-cone; pfam03477
608538000642	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
608538000643	Class III ribonucleotide reductase; Region: RNR_III; cd01675
608538000644	effector binding site; other site
608538000645	active site
608538000646	Zn binding site [ion binding]; other site
608538000647	glycine loop; other site
608538000648	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538000649	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
608538000650	Permease; Region: Permease; cl00510
608538000651	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
608538000652	Tetramer interface [polypeptide binding]; other site
608538000653	active site
608538000654	FMN-binding site [chemical binding]; other site
608538000655	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
608538000656	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
608538000657	SCP-2 sterol transfer family; Region: SCP2; cl01225
608538000658	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
608538000659	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
608538000660	dimerization interface 3.5A [polypeptide binding]; other site
608538000661	active site
608538000662	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
608538000663	TPR repeat; Region: TPR_11; pfam13414
608538000664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000665	binding surface
608538000666	TPR motif; other site
608538000667	TPR repeat; Region: TPR_11; pfam13414
608538000668	signal recognition particle protein; Provisional; Region: PRK10867
608538000669	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
608538000670	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
608538000671	P loop; other site
608538000672	GTP binding site [chemical binding]; other site
608538000673	Signal peptide binding domain; Region: SRP_SPB; pfam02978
608538000674	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
608538000675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538000676	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538000677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000678	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538000679	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538000680	catalytic residues [active]
608538000681	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538000682	dimerization interface [polypeptide binding]; other site
608538000683	putative DNA binding site [nucleotide binding]; other site
608538000684	putative Zn2+ binding site [ion binding]; other site
608538000685	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
608538000686	Organic solvent tolerance protein; Region: OstA_C; pfam04453
608538000687	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
608538000688	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
608538000689	substrate binding site [chemical binding]; other site
608538000690	hexamer interface [polypeptide binding]; other site
608538000691	metal binding site [ion binding]; metal-binding site
608538000692	PLD-like domain; Region: PLDc_2; pfam13091
608538000693	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
608538000694	putative active site [active]
608538000695	catalytic site [active]
608538000696	Domain of unknown function DUF87; Region: DUF87; pfam01935
608538000697	AAA-like domain; Region: AAA_10; pfam12846
608538000698	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
608538000699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
608538000700	Coenzyme A binding pocket [chemical binding]; other site
608538000701	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
608538000702	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
608538000703	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
608538000704	metal binding site [ion binding]; metal-binding site
608538000705	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
608538000706	homodimer interface [polypeptide binding]; other site
608538000707	substrate-cofactor binding pocket; other site
608538000708	catalytic residue [active]
608538000709	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
608538000710	putative ligand binding pocket/active site [active]
608538000711	putative metal binding site [ion binding]; other site
608538000712	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
608538000713	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
608538000714	tandem repeat interface [polypeptide binding]; other site
608538000715	oligomer interface [polypeptide binding]; other site
608538000716	active site residues [active]
608538000717	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
608538000718	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
608538000719	Walker A/P-loop; other site
608538000720	ATP binding site [chemical binding]; other site
608538000721	Q-loop/lid; other site
608538000722	ABC transporter signature motif; other site
608538000723	Walker B; other site
608538000724	D-loop; other site
608538000725	H-loop/switch region; other site
608538000726	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
608538000727	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538000728	N-terminal plug; other site
608538000729	ligand-binding site [chemical binding]; other site
608538000730	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
608538000731	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
608538000732	Gram-negative bacterial tonB protein; Region: TonB; cl10048
608538000733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
608538000734	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
608538000735	Phosphopantetheine attachment site; Region: PP-binding; cl09936
608538000736	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
608538000737	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
608538000738	dimer interface [polypeptide binding]; other site
608538000739	active site
608538000740	ribonuclease III; Reviewed; Region: rnc; PRK00102
608538000741	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
608538000742	dimerization interface [polypeptide binding]; other site
608538000743	active site
608538000744	metal binding site [ion binding]; metal-binding site
608538000745	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
608538000746	dsRNA binding site [nucleotide binding]; other site
608538000747	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
608538000748	active site
608538000749	metal binding site [ion binding]; metal-binding site
608538000750	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
608538000751	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538000752	minor groove reading motif; other site
608538000753	helix-hairpin-helix signature motif; other site
608538000754	substrate binding pocket [chemical binding]; other site
608538000755	active site
608538000756	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
608538000757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000758	Walker A/P-loop; other site
608538000759	ATP binding site [chemical binding]; other site
608538000760	Q-loop/lid; other site
608538000761	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
608538000762	ABC transporter signature motif; other site
608538000763	Walker B; other site
608538000764	D-loop; other site
608538000765	H-loop/switch region; other site
608538000766	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
608538000767	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
608538000768	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
608538000769	beta subunit interaction interface [polypeptide binding]; other site
608538000770	Walker A motif; other site
608538000771	ATP binding site [chemical binding]; other site
608538000772	Walker B motif; other site
608538000773	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
608538000774	Protein of unknown function DUF72; Region: DUF72; cl00777
608538000775	TPR repeat; Region: TPR_11; pfam13414
608538000776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000777	binding surface
608538000778	TPR motif; other site
608538000779	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538000780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538000781	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
608538000782	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
608538000783	NurA domain; Region: NurA; cl09134
608538000784	Membrane transport protein; Region: Mem_trans; cl09117
608538000785	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
608538000786	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
608538000787	NAD binding site [chemical binding]; other site
608538000788	putative substrate binding site 2 [chemical binding]; other site
608538000789	putative substrate binding site 1 [chemical binding]; other site
608538000790	active site
608538000791	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
608538000792	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
608538000793	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
608538000794	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
608538000795	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
608538000796	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
608538000797	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538000798	nucleotide binding region [chemical binding]; other site
608538000799	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
608538000800	active site
608538000801	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
608538000802	homodimer interface [polypeptide binding]; other site
608538000803	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
608538000804	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
608538000805	DXD motif; other site
608538000806	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
608538000807	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
608538000808	putative active site [active]
608538000809	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
608538000810	active site
608538000811	hydrophilic channel; other site
608538000812	dimerization interface [polypeptide binding]; other site
608538000813	catalytic residues [active]
608538000814	active site lid [active]
608538000815	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
608538000816	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
608538000817	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
608538000818	active site
608538000819	catalytic residues [active]
608538000820	metal binding site [ion binding]; metal-binding site
608538000821	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538000822	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
608538000823	Cytochrome c; Region: Cytochrom_C; cl11414
608538000824	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
608538000825	ResB-like family; Region: ResB; pfam05140
608538000826	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
608538000827	PLD-like domain; Region: PLDc_2; pfam13091
608538000828	putative homodimer interface [polypeptide binding]; other site
608538000829	putative active site [active]
608538000830	catalytic site [active]
608538000831	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538000832	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
608538000833	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538000834	nucleotide binding region [chemical binding]; other site
608538000835	ATP-binding site [chemical binding]; other site
608538000836	Transposase IS200 like; Region: Y1_Tnp; cl00848
608538000837	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
608538000838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538000839	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
608538000840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538000841	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
608538000842	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538000843	active site
608538000844	NTP binding site [chemical binding]; other site
608538000845	metal binding triad [ion binding]; metal-binding site
608538000846	antibiotic binding site [chemical binding]; other site
608538000847	Protein of unknown function DUF86; Region: DUF86; cl01031
608538000848	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
608538000849	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000850	active site
608538000851	HIGH motif; other site
608538000852	nucleotide binding site [chemical binding]; other site
608538000853	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
608538000854	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000855	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000856	active site
608538000857	KMSKS motif; other site
608538000858	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
608538000859	tRNA binding surface [nucleotide binding]; other site
608538000860	anticodon binding site; other site
608538000861	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
608538000862	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
608538000863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000864	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
608538000865	NAD(P) binding site [chemical binding]; other site
608538000866	active site
608538000867	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
608538000868	feedback inhibition sensing region; other site
608538000869	homohexameric interface [polypeptide binding]; other site
608538000870	nucleotide binding site [chemical binding]; other site
608538000871	N-acetyl-L-glutamate binding site [chemical binding]; other site
608538000872	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
608538000873	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
608538000874	active site
608538000875	DNA binding site [nucleotide binding]
608538000876	Int/Topo IB signature motif; other site
608538000877	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
608538000878	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538000879	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
608538000880	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538000881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538000882	FeS/SAM binding site; other site
608538000883	Fumarase C-terminus; Region: Fumerase_C; cl00795
608538000884	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
608538000885	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
608538000886	Walker A motif; other site
608538000887	ATP binding site [chemical binding]; other site
608538000888	Walker B motif; other site
608538000889	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538000890	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
608538000891	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
608538000892	GTP-binding protein YchF; Reviewed; Region: PRK09601
608538000893	YchF GTPase; Region: YchF; cd01900
608538000894	G1 box; other site
608538000895	GTP/Mg2+ binding site [chemical binding]; other site
608538000896	Switch I region; other site
608538000897	G2 box; other site
608538000898	Switch II region; other site
608538000899	G3 box; other site
608538000900	G4 box; other site
608538000901	G5 box; other site
608538000902	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
608538000903	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538000904	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538000905	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
608538000906	putative active site [active]
608538000907	putative metal binding site [ion binding]; other site
608538000908	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
608538000909	Catalytic domain of Protein Kinases; Region: PKc; cd00180
608538000910	active site
608538000911	ATP binding site [chemical binding]; other site
608538000912	substrate binding site [chemical binding]; other site
608538000913	activation loop (A-loop); other site
608538000914	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
608538000915	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
608538000916	active site
608538000917	NAD binding site [chemical binding]; other site
608538000918	metal binding site [ion binding]; metal-binding site
608538000919	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
608538000920	SurA N-terminal domain; Region: SurA_N_3; cl07813
608538000921	PPIC-type PPIASE domain; Region: Rotamase; cl08278
608538000922	periplasmic folding chaperone; Provisional; Region: PRK10788
608538000923	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
608538000924	active site
608538000925	oxalacetate binding site [chemical binding]; other site
608538000926	citrylCoA binding site [chemical binding]; other site
608538000927	coenzyme A binding site [chemical binding]; other site
608538000928	catalytic triad [active]
608538000929	homoserine dehydrogenase; Provisional; Region: PRK06349
608538000930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000931	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
608538000932	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
608538000933	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
608538000934	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
608538000935	active site
608538000936	DNA repair protein RadA; Provisional; Region: PRK11823
608538000937	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
608538000938	Walker A motif/ATP binding site; other site
608538000939	ATP binding site [chemical binding]; other site
608538000940	Walker B motif; other site
608538000941	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
608538000942	FeoA domain; Region: FeoA; cl00838
608538000943	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
608538000944	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
608538000945	G1 box; other site
608538000946	GTP/Mg2+ binding site [chemical binding]; other site
608538000947	Switch I region; other site
608538000948	G2 box; other site
608538000949	G3 box; other site
608538000950	Switch II region; other site
608538000951	G4 box; other site
608538000952	G5 box; other site
608538000953	Nucleoside recognition; Region: Gate; cl00486
608538000954	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
608538000955	Nucleoside recognition; Region: Gate; cl00486
608538000956	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538000957	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
608538000958	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
608538000959	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
608538000960	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
608538000961	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
608538000962	active site
608538000963	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
608538000964	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
608538000965	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
608538000966	putative substrate binding pocket [chemical binding]; other site
608538000967	dimer interface [polypeptide binding]; other site
608538000968	phosphate binding site [ion binding]; other site
608538000969	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
608538000970	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000971	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
608538000972	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
608538000973	tetramer interfaces [polypeptide binding]; other site
608538000974	binuclear metal-binding site [ion binding]; other site
608538000975	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
608538000976	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
608538000977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
608538000978	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
608538000979	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
608538000980	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
608538000981	tRNA; other site
608538000982	putative tRNA binding site [nucleotide binding]; other site
608538000983	putative NADP binding site [chemical binding]; other site
608538000984	AsnC family; Region: AsnC_trans_reg; pfam01037
608538000985	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
608538000986	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
608538000987	hinge; other site
608538000988	active site
608538000989	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
608538000990	putative dimer interface [polypeptide binding]; other site
608538000991	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
608538000992	Isochorismatase family; Region: Isochorismatase; pfam00857
608538000993	catalytic triad [active]
608538000994	metal binding site [ion binding]; metal-binding site
608538000995	conserved cis-peptide bond; other site
608538000996	Sugar fermentation stimulation protein; Region: SfsA; cl00647
608538000997	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538000998	G2 box; other site
608538000999	Switch I region; other site
608538001000	G3 box; other site
608538001001	Switch II region; other site
608538001002	GTP/Mg2+ binding site [chemical binding]; other site
608538001003	G4 box; other site
608538001004	G5 box; other site
608538001005	HEAT repeats; Region: HEAT_2; pfam13646
608538001006	Ferrochelatase; Region: Ferrochelatase; pfam00762
608538001007	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
608538001008	C-terminal domain interface [polypeptide binding]; other site
608538001009	active site
608538001010	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
608538001011	active site
608538001012	N-terminal domain interface [polypeptide binding]; other site
608538001013	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
608538001014	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538001015	Walker A/P-loop; other site
608538001016	ATP binding site [chemical binding]; other site
608538001017	Q-loop/lid; other site
608538001018	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
608538001019	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
608538001020	ABC transporter signature motif; other site
608538001021	Walker B; other site
608538001022	D-loop; other site
608538001023	H-loop/switch region; other site
608538001024	Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862
608538001025	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
608538001026	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
608538001027	Uncharacterized conserved protein [Function unknown]; Region: COG1432
608538001028	LabA_like proteins; Region: LabA_like/DUF88; cl10034
608538001029	putative metal binding site [ion binding]; other site
608538001030	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
608538001031	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
608538001032	active site
608538001033	Riboflavin kinase; Region: Flavokinase; cl03312
608538001034	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
608538001035	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
608538001036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001037	Walker A motif; other site
608538001038	ATP binding site [chemical binding]; other site
608538001039	Walker B motif; other site
608538001040	arginine finger; other site
608538001041	Helix-turn-helix domains; Region: HTH; cl00088
608538001042	SCP-2 sterol transfer family; Region: SCP2; cl01225
608538001043	Uncharacterized conserved protein (DUF2173); Region: DUF2173; cl01994
608538001044	Uncharacterized conserved protein (DUF2173); Region: DUF2173; cl01994
608538001045	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
608538001046	K+ potassium transporter; Region: K_trans; cl15781
608538001047	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
608538001048	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
608538001049	dimer interface [polypeptide binding]; other site
608538001050	anticodon binding site; other site
608538001051	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
608538001052	homodimer interface [polypeptide binding]; other site
608538001053	motif 1; other site
608538001054	active site
608538001055	motif 2; other site
608538001056	GAD domain; Region: GAD; pfam02938
608538001057	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
608538001058	motif 3; other site
608538001059	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538001060	active site
608538001061	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
608538001062	histidinol dehydrogenase; Region: hisD; TIGR00069
608538001063	NAD binding site [chemical binding]; other site
608538001064	dimerization interface [polypeptide binding]; other site
608538001065	product binding site; other site
608538001066	substrate binding site [chemical binding]; other site
608538001067	zinc binding site [ion binding]; other site
608538001068	catalytic residues [active]
608538001069	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
608538001070	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538001071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001072	homodimer interface [polypeptide binding]; other site
608538001073	catalytic residue [active]
608538001074	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
608538001075	FOG: CBS domain [General function prediction only]; Region: COG0517
608538001076	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
608538001077	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
608538001078	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
608538001079	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
608538001080	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538001081	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
608538001082	Domain of unknown function DUF20; Region: UPF0118; pfam01594
608538001083	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
608538001084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001085	TPR motif; other site
608538001086	binding surface
608538001087	TPR repeat; Region: TPR_11; pfam13414
608538001088	chorismate binding enzyme; Region: Chorismate_bind; cl10555
608538001089	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
608538001090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001091	catalytic residue [active]
608538001092	ribonuclease R; Region: RNase_R; TIGR02063
608538001093	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538001094	RNB domain; Region: RNB; pfam00773
608538001095	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
608538001096	RNA binding site [nucleotide binding]; other site
608538001097	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
608538001098	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
608538001099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538001101	dimer interface [polypeptide binding]; other site
608538001102	conserved gate region; other site
608538001103	putative PBP binding loops; other site
608538001104	ABC-ATPase subunit interface; other site
608538001105	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
608538001106	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
608538001107	FAD binding pocket [chemical binding]; other site
608538001108	FAD binding motif [chemical binding]; other site
608538001109	phosphate binding motif [ion binding]; other site
608538001110	beta-alpha-beta structure motif; other site
608538001111	NAD binding pocket [chemical binding]; other site
608538001112	Iron coordination center [ion binding]; other site
608538001113	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
608538001114	Lumazine binding domain; Region: Lum_binding; pfam00677
608538001115	Lumazine binding domain; Region: Lum_binding; pfam00677
608538001116	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
608538001117	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
608538001118	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
608538001119	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
608538001120	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
608538001121	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
608538001122	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
608538001123	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
608538001124	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
608538001125	dimer interface [polypeptide binding]; other site
608538001126	ssDNA binding site [nucleotide binding]; other site
608538001127	tetramer (dimer of dimers) interface [polypeptide binding]; other site
608538001128	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
608538001129	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
608538001130	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
608538001131	Coenzyme A binding pocket [chemical binding]; other site
608538001132	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
608538001133	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
608538001134	catalytic site [active]
608538001135	putative active site [active]
608538001136	putative substrate binding site [chemical binding]; other site
608538001137	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
608538001138	active site
608538001139	DNA binding site [nucleotide binding]
608538001140	catalytic site [active]
608538001141	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
608538001142	putative active site [active]
608538001143	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
608538001144	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
608538001145	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
608538001146	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
608538001147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001148	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
608538001149	Cytochrome c; Region: Cytochrom_C; cl11414
608538001150	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
608538001151	putative hydrophobic ligand binding site [chemical binding]; other site
608538001152	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
608538001153	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
608538001154	XdhC Rossmann domain; Region: XdhC_C; pfam13478
608538001155	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
608538001156	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
608538001157	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
608538001158	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
608538001159	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538001160	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
608538001161	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
608538001162	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
608538001163	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538001164	N-terminal plug; other site
608538001165	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
608538001166	ligand-binding site [chemical binding]; other site
608538001167	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
608538001168	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306
608538001169	membrane-bound complex binding site; other site
608538001170	hinge residues; other site
608538001171	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
608538001172	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
608538001173	structural tetrad; other site
608538001174	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
608538001175	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
608538001176	Trp docking motif [polypeptide binding]; other site
608538001177	dimer interface [polypeptide binding]; other site
608538001178	active site
608538001179	small subunit binding site [polypeptide binding]; other site
608538001180	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
608538001181	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
608538001182	putative ligand binding site [chemical binding]; other site
608538001183	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
608538001184	TM-ABC transporter signature motif; other site
608538001185	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
608538001186	TM-ABC transporter signature motif; other site
608538001187	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
608538001188	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
608538001189	Walker A/P-loop; other site
608538001190	ATP binding site [chemical binding]; other site
608538001191	Q-loop/lid; other site
608538001192	ABC transporter signature motif; other site
608538001193	Walker B; other site
608538001194	D-loop; other site
608538001195	H-loop/switch region; other site
608538001196	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
608538001197	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
608538001198	Walker A/P-loop; other site
608538001199	ATP binding site [chemical binding]; other site
608538001200	Q-loop/lid; other site
608538001201	ABC transporter signature motif; other site
608538001202	Walker B; other site
608538001203	D-loop; other site
608538001204	H-loop/switch region; other site
608538001205	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
608538001206	Radical SAM superfamily; Region: Radical_SAM; pfam04055
608538001207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001208	FeS/SAM binding site; other site
608538001209	PSP1 C-terminal conserved region; Region: PSP1; cl00770
608538001210	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
608538001211	4Fe-4S binding domain; Region: Fer4; cl02805
608538001212	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
608538001213	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
608538001214	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
608538001215	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
608538001216	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
608538001217	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538001218	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
608538001219	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538001220	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
608538001221	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538001222	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
608538001223	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
608538001224	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
608538001225	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538001226	NADH dehydrogenase; Region: NADHdh; cl00469
608538001227	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
608538001228	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
608538001229	substrate binding site [chemical binding]; other site
608538001230	glutamase interaction surface [polypeptide binding]; other site
608538001231	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
608538001232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538001233	ATP binding site [chemical binding]; other site
608538001234	Mg2+ binding site [ion binding]; other site
608538001235	G-X-G motif; other site
608538001236	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
608538001237	ATP binding site [chemical binding]; other site
608538001238	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
608538001239	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
608538001240	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
608538001241	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
608538001242	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
608538001243	heterodimer interface [polypeptide binding]; other site
608538001244	active site
608538001245	FMN binding site [chemical binding]; other site
608538001246	homodimer interface [polypeptide binding]; other site
608538001247	substrate binding site [chemical binding]; other site
608538001248	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
608538001249	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
608538001250	GDP-binding site [chemical binding]; other site
608538001251	ACT binding site; other site
608538001252	IMP binding site; other site
608538001253	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
608538001254	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
608538001255	HflX GTPase family; Region: HflX; cd01878
608538001256	G1 box; other site
608538001257	GTP/Mg2+ binding site [chemical binding]; other site
608538001258	Switch I region; other site
608538001259	G2 box; other site
608538001260	G3 box; other site
608538001261	Switch II region; other site
608538001262	G4 box; other site
608538001263	G5 box; other site
608538001264	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
608538001265	Sm1 motif; other site
608538001266	D1 - D2 interaction site; other site
608538001267	D3 - B interaction site; other site
608538001268	Hfq - Hfq interaction site; other site
608538001269	RNA binding pocket [nucleotide binding]; other site
608538001270	Sm2 motif; other site
608538001271	acetylornithine aminotransferase; Provisional; Region: PRK02627
608538001272	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538001273	inhibitor-cofactor binding pocket; inhibition site
608538001274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001275	catalytic residue [active]
608538001276	NAD synthetase; Provisional; Region: PRK13981
608538001277	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
608538001278	multimer interface [polypeptide binding]; other site
608538001279	active site
608538001280	catalytic triad [active]
608538001281	protein interface 1 [polypeptide binding]; other site
608538001282	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
608538001283	homodimer interface [polypeptide binding]; other site
608538001284	NAD binding pocket [chemical binding]; other site
608538001285	ATP binding pocket [chemical binding]; other site
608538001286	Mg binding site [ion binding]; other site
608538001287	active-site loop [active]
608538001288	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
608538001289	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538001290	Walker A motif; other site
608538001291	ATP binding site [chemical binding]; other site
608538001292	Walker B motif; other site
608538001293	Preprotein translocase subunit; Region: YajC; cl00806
608538001294	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538001295	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538001296	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538001297	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14953
608538001298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001299	Walker A motif; other site
608538001300	ATP binding site [chemical binding]; other site
608538001301	Walker B motif; other site
608538001302	arginine finger; other site
608538001303	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
608538001304	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
608538001305	putative active site [active]
608538001306	catalytic triad [active]
608538001307	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
608538001308	Restriction endonuclease; Region: Mrr_cat; cl00516
608538001309	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
608538001310	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
608538001311	putative ribose interaction site [chemical binding]; other site
608538001312	putative ADP binding site [chemical binding]; other site
608538001313	aspartate kinase; Reviewed; Region: PRK06635
608538001314	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
608538001315	putative nucleotide binding site [chemical binding]; other site
608538001316	putative catalytic residues [active]
608538001317	putative Mg ion binding site [ion binding]; other site
608538001318	putative aspartate binding site [chemical binding]; other site
608538001319	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
608538001320	putative allosteric regulatory site; other site
608538001321	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
608538001322	putative allosteric regulatory residue; other site
608538001323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001324	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538001325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001326	Walker A motif; other site
608538001327	ATP binding site [chemical binding]; other site
608538001328	Walker B motif; other site
608538001329	arginine finger; other site
608538001330	Helix-turn-helix domains; Region: HTH; cl00088
608538001331	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
608538001332	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538001333	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538001334	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538001335	MoaE interaction surface [polypeptide binding]; other site
608538001336	MoeB interaction surface [polypeptide binding]; other site
608538001337	thiocarboxylated glycine; other site
608538001338	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
608538001339	Active Sites [active]
608538001340	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
608538001341	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
608538001342	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
608538001343	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
608538001344	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
608538001345	ATP-sulfurylase; Region: ATPS; cd00517
608538001346	active site
608538001347	HXXH motif; other site
608538001348	flexible loop; other site
608538001349	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538001350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001351	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538001352	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538001353	Heme NO binding; Region: HNOB; cl15268
608538001354	NifU-like domain; Region: NifU; cl00484
608538001355	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
608538001356	iron-sulfur cluster [ion binding]; other site
608538001357	[2Fe-2S] cluster binding site [ion binding]; other site
608538001358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538001359	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001360	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
608538001361	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
608538001362	nickel binding site [ion binding]; other site
608538001363	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538001364	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538001365	Protein of unknown function (DUF1641); Region: DUF1641; cl01025
608538001366	Protein of unknown function (DUF1641); Region: DUF1641; cl01025
608538001367	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
608538001368	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
608538001369	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
608538001370	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
608538001371	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
608538001372	Walker A/P-loop; other site
608538001373	ATP binding site [chemical binding]; other site
608538001374	Q-loop/lid; other site
608538001375	ABC transporter signature motif; other site
608538001376	Walker B; other site
608538001377	D-loop; other site
608538001378	H-loop/switch region; other site
608538001379	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
608538001380	active site
608538001381	catalytic residues [active]
608538001382	metal binding site [ion binding]; metal-binding site
608538001383	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
608538001384	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
608538001385	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
608538001386	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
608538001387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001388	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
608538001389	PhoU domain; Region: PhoU; pfam01895
608538001390	PhoU domain; Region: PhoU; pfam01895
608538001391	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
608538001392	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
608538001393	dimerization interface [polypeptide binding]; other site
608538001394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538001395	dimer interface [polypeptide binding]; other site
608538001396	phosphorylation site [posttranslational modification]
608538001397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538001398	ATP binding site [chemical binding]; other site
608538001399	Mg2+ binding site [ion binding]; other site
608538001400	G-X-G motif; other site
608538001401	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538001402	Acyl transferase domain; Region: Acyl_transf_1; cl08282
608538001403	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
608538001404	AAA domain; Region: AAA_32; pfam13654
608538001405	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
608538001406	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
608538001407	Domain of unknown function DUF77; Region: DUF77; cl00307
608538001408	YceG-like family; Region: YceG; pfam02618
608538001409	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
608538001410	dimerization interface [polypeptide binding]; other site
608538001411	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
608538001412	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
608538001413	Protein of unknown function (DUF1122); Region: DUF1122; cl01800
608538001414	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
608538001415	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
608538001416	dimer interface [polypeptide binding]; other site
608538001417	motif 1; other site
608538001418	active site
608538001419	motif 2; other site
608538001420	motif 3; other site
608538001421	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
608538001422	anticodon binding site; other site
608538001423	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
608538001424	dimer interface [polypeptide binding]; other site
608538001425	active site
608538001426	Schiff base residues; other site
608538001427	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14331
608538001428	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538001429	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001430	FeS/SAM binding site; other site
608538001431	TRAM domain; Region: TRAM; cl01282
608538001432	Bifunctional nuclease; Region: DNase-RNase; cl00553
608538001433	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
608538001434	active site
608538001435	putative substrate binding region [chemical binding]; other site
608538001436	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
608538001437	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
608538001438	NAD(P) binding site [chemical binding]; other site
608538001439	homotetramer interface [polypeptide binding]; other site
608538001440	homodimer interface [polypeptide binding]; other site
608538001441	active site
608538001442	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
608538001443	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
608538001444	active site
608538001445	metal binding site [ion binding]; metal-binding site
608538001446	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
608538001447	domain I; other site
608538001448	DNA binding groove [nucleotide binding]
608538001449	phosphate binding site [ion binding]; other site
608538001450	domain II; other site
608538001451	domain III; other site
608538001452	nucleotide binding site [chemical binding]; other site
608538001453	catalytic site [active]
608538001454	domain IV; other site
608538001455	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
608538001456	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
608538001457	Sm1 motif; other site
608538001458	intra - hexamer interaction site; other site
608538001459	inter - hexamer interaction site [polypeptide binding]; other site
608538001460	nucleotide binding pocket [chemical binding]; other site
608538001461	Sm2 motif; other site
608538001462	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
608538001463	dimer interface [polypeptide binding]; other site
608538001464	[2Fe-2S] cluster binding site [ion binding]; other site
608538001465	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
608538001466	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538001467	Family description; Region: UvrD_C_2; cl15862
608538001468	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538001469	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538001470	Protein of unknown function (DUF554); Region: DUF554; cl00784
608538001471	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538001472	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538001473	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538001474	Predicted GTPase [General function prediction only]; Region: COG0218
608538001475	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
608538001476	G1 box; other site
608538001477	GTP/Mg2+ binding site [chemical binding]; other site
608538001478	Switch I region; other site
608538001479	G2 box; other site
608538001480	G3 box; other site
608538001481	Switch II region; other site
608538001482	G4 box; other site
608538001483	G5 box; other site
608538001484	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
608538001485	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538001486	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538001487	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
608538001488	DNA-binding site [nucleotide binding]; DNA binding site
608538001489	RNA-binding motif; other site
608538001490	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
608538001491	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
608538001492	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
608538001493	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
608538001494	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
608538001495	putative NAD(P) binding site [chemical binding]; other site
608538001496	active site
608538001497	Predicted transcriptional regulators [Transcription]; Region: COG1318
608538001498	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
608538001499	Family of unknown function (DUF490); Region: DUF490; pfam04357
608538001500	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538001501	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
608538001502	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
608538001503	putative active site [active]
608538001504	catalytic triad [active]
608538001505	putative dimer interface [polypeptide binding]; other site
608538001506	EamA-like transporter family; Region: EamA; cl01037
608538001507	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
608538001508	putative catalytic site [active]
608538001509	putative phosphate binding site [ion binding]; other site
608538001510	active site
608538001511	metal binding site A [ion binding]; metal-binding site
608538001512	DNA binding site [nucleotide binding]
608538001513	putative AP binding site [nucleotide binding]; other site
608538001514	putative metal binding site B [ion binding]; other site
608538001515	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538001516	IHF dimer interface [polypeptide binding]; other site
608538001517	IHF - DNA interface [nucleotide binding]; other site
608538001518	RecT family; Region: RecT; cl04285
608538001519	Cyclin-dependent kinase regulatory subunit; Region: CKS; cl03104
608538001520	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
608538001521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
608538001522	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
608538001523	Catalytic site [active]
608538001524	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
608538001525	CHC2 zinc finger; Region: zf-CHC2; cl15369
608538001526	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
608538001527	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538001528	Family description; Region: UvrD_C_2; cl15862
608538001529	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
608538001530	active site
608538001531	putative DNA-binding cleft [nucleotide binding]; other site
608538001532	dimer interface [polypeptide binding]; other site
608538001533	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
608538001534	Active Sites [active]
608538001535	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
608538001536	active site
608538001537	metal binding site [ion binding]; metal-binding site
608538001538	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
608538001539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
608538001540	Terminase-like family; Region: Terminase_6; pfam03237
608538001541	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
608538001542	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
608538001543	sugar binding site [chemical binding]; other site
608538001544	replication factor A; Reviewed; Region: PRK08402
608538001545	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
608538001546	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
608538001547	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
608538001548	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538001549	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538001550	catalytic residue [active]
608538001551	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
608538001552	putative DNA binding surface [nucleotide binding]; other site
608538001553	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
608538001554	dimer interface [polypeptide binding]; other site
608538001555	beta-clamp/clamp loader binding surface; other site
608538001556	beta-clamp/translesion DNA polymerase binding surface; other site
608538001557	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
608538001558	DHH family; Region: DHH; pfam01368
608538001559	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
608538001560	FOG: CBS domain [General function prediction only]; Region: COG0517
608538001561	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
608538001562	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
608538001563	active site
608538001564	NTP binding site [chemical binding]; other site
608538001565	metal binding triad [ion binding]; metal-binding site
608538001566	Predicted permease; Region: DUF318; pfam03773
608538001567	Predicted permeases [General function prediction only]; Region: COG0701
608538001568	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
608538001569	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
608538001570	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538001571	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
608538001572	G1 box; other site
608538001573	GTP/Mg2+ binding site [chemical binding]; other site
608538001574	G2 box; other site
608538001575	Switch I region; other site
608538001576	G3 box; other site
608538001577	Switch II region; other site
608538001578	G4 box; other site
608538001579	G5 box; other site
608538001580	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
608538001581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001582	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
608538001583	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
608538001584	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
608538001585	23S rRNA interface [nucleotide binding]; other site
608538001586	L3 interface [polypeptide binding]; other site
608538001587	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
608538001588	substrate binding site [chemical binding]; other site
608538001589	lipoyl synthase; Provisional; Region: PRK05481
608538001590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001591	FeS/SAM binding site; other site
608538001592	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
608538001593	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
608538001594	FAD binding pocket [chemical binding]; other site
608538001595	FAD binding motif [chemical binding]; other site
608538001596	phosphate binding motif [ion binding]; other site
608538001597	beta-alpha-beta structure motif; other site
608538001598	NAD binding pocket [chemical binding]; other site
608538001599	Iron coordination center [ion binding]; other site
608538001600	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538001601	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538001602	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538001603	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
608538001604	catalytic residues [active]
608538001605	Rhomboid family; Region: Rhomboid; cl11446
608538001606	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
608538001607	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
608538001608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001609	TPR motif; other site
608538001610	binding surface
608538001611	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001613	binding surface
608538001614	TPR motif; other site
608538001615	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001616	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001617	Protein of unknown function (DUF503); Region: DUF503; cl00669
608538001618	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
608538001619	MPN+ (JAMM) motif; other site
608538001620	Zinc-binding site [ion binding]; other site
608538001621	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
608538001622	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001623	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
608538001624	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538001625	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
608538001626	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
608538001627	putative amphipathic alpha helix; other site
608538001628	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
608538001629	peptide chain release factor 2; Validated; Region: prfB; PRK00578
608538001630	RF-1 domain; Region: RF-1; cl02875
608538001631	RF-1 domain; Region: RF-1; cl02875
608538001632	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
608538001633	GTP1/OBG; Region: GTP1_OBG; pfam01018
608538001634	Obg GTPase; Region: Obg; cd01898
608538001635	G1 box; other site
608538001636	GTP/Mg2+ binding site [chemical binding]; other site
608538001637	Switch I region; other site
608538001638	G2 box; other site
608538001639	G3 box; other site
608538001640	Switch II region; other site
608538001641	G4 box; other site
608538001642	G5 box; other site
608538001643	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538001644	catalytic residues [active]
608538001645	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
608538001646	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538001647	catalytic residue [active]
608538001648	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
608538001649	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
608538001650	HIGH motif; other site
608538001651	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
608538001652	active site
608538001653	KMSKS motif; other site
608538001654	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
608538001655	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
608538001656	active site
608538001657	homodimer interface [polypeptide binding]; other site
608538001658	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
608538001659	active site
608538001660	tetramer interface; other site
608538001661	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538001662	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
608538001663	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538001664	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
608538001665	Surface antigen; Region: Bac_surface_Ag; cl03097
608538001666	aspartate aminotransferase; Provisional; Region: PRK05764
608538001667	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538001668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001669	homodimer interface [polypeptide binding]; other site
608538001670	catalytic residue [active]
608538001671	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
608538001672	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
608538001673	ligand binding site [chemical binding]; other site
608538001674	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
608538001675	dimer interface [polypeptide binding]; other site
608538001676	putative tRNA-binding site [nucleotide binding]; other site
608538001677	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
608538001678	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
608538001679	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
608538001680	dimer interface [polypeptide binding]; other site
608538001681	putative functional site; other site
608538001682	putative MPT binding site; other site
608538001683	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
608538001684	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
608538001685	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
608538001686	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
608538001687	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
608538001688	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
608538001689	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
608538001690	substrate binding site [chemical binding]; other site
608538001691	dimer interface [polypeptide binding]; other site
608538001692	catalytic triad [active]
608538001693	UbiA prenyltransferase family; Region: UbiA; cl00337
608538001694	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
608538001695	replicative DNA helicase; Region: DnaB; TIGR00665
608538001696	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
608538001697	Walker A motif; other site
608538001698	ATP binding site [chemical binding]; other site
608538001699	Walker B motif; other site
608538001700	DNA binding loops [nucleotide binding]
608538001701	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
608538001702	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
608538001703	FAD binding site [chemical binding]; other site
608538001704	GYD domain; Region: GYD; cl01743
608538001705	Cytochrome c; Region: Cytochrom_C; cl11414
608538001706	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
608538001707	Ligand Binding Site [chemical binding]; other site
608538001708	TIGR00269 family protein; Region: TIGR00269
608538001709	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
608538001710	active site residue [active]
608538001711	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
608538001712	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538001713	catalytic residue [active]
608538001714	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
608538001715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538001716	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
608538001717	Domain of unknown function DUF21; Region: DUF21; pfam01595
608538001718	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
608538001719	Transporter associated domain; Region: CorC_HlyC; cl08393
608538001720	hypothetical protein; Reviewed; Region: PRK00024
608538001721	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
608538001722	MPN+ (JAMM) motif; other site
608538001723	Zinc-binding site [ion binding]; other site
608538001724	putative phosphoketolase; Provisional; Region: PRK05261
608538001725	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
608538001726	TPP-binding site; other site
608538001727	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
608538001728	XFP C-terminal domain; Region: XFP_C; pfam09363
608538001729	Acetokinase family; Region: Acetate_kinase; cl01029
608538001730	acetate kinase; Region: ackA; TIGR00016
608538001731	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
608538001732	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
608538001733	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
608538001734	homodimer interface [polypeptide binding]; other site
608538001735	NADP binding site [chemical binding]; other site
608538001736	substrate binding site [chemical binding]; other site
608538001737	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538001738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001739	S-adenosylmethionine binding site [chemical binding]; other site
608538001740	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
608538001741	Cytochrome c; Region: Cytochrom_C; cl11414
608538001742	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
608538001743	Nucleotide binding site [chemical binding]; other site
608538001744	DTAP/Switch II; other site
608538001745	Switch I; other site
608538001746	amino acid transporter; Region: 2A0306; TIGR00909
608538001747	Spore germination protein; Region: Spore_permease; cl15802
608538001748	Spore germination protein; Region: Spore_permease; cl15802
608538001749	Spore germination protein; Region: Spore_permease; cl15802
608538001750	Staphylococcal nuclease homologues; Region: SNc; smart00318
608538001751	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
608538001752	Catalytic site; other site
608538001753	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
608538001754	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
608538001755	PYR/PP interface [polypeptide binding]; other site
608538001756	dimer interface [polypeptide binding]; other site
608538001757	TPP binding site [chemical binding]; other site
608538001758	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
608538001759	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
608538001760	TPP-binding site [chemical binding]; other site
608538001761	dimer interface [polypeptide binding]; other site
608538001762	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
608538001763	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
608538001764	putative valine binding site [chemical binding]; other site
608538001765	dimer interface [polypeptide binding]; other site
608538001766	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
608538001767	multifunctional aminopeptidase A; Provisional; Region: PRK00913
608538001768	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
608538001769	interface (dimer of trimers) [polypeptide binding]; other site
608538001770	Substrate-binding/catalytic site; other site
608538001771	Zn-binding sites [ion binding]; other site
608538001772	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
608538001773	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
608538001774	dimerization interface [polypeptide binding]; other site
608538001775	active site
608538001776	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538001777	glycogen synthase; Provisional; Region: glgA; PRK00654
608538001778	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
608538001779	ADP-binding pocket [chemical binding]; other site
608538001780	homodimer interface [polypeptide binding]; other site
608538001781	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
608538001782	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538001783	active site
608538001784	nucleotide binding site [chemical binding]; other site
608538001785	HIGH motif; other site
608538001786	KMSKS motif; other site
608538001787	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538001788	active site
608538001789	NTP binding site [chemical binding]; other site
608538001790	metal binding triad [ion binding]; metal-binding site
608538001791	antibiotic binding site [chemical binding]; other site
608538001792	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
608538001793	Recombination protein O N terminal; Region: RecO_N; cl15812
608538001794	Pantoate-beta-alanine ligase; Region: PanC; cd00560
608538001795	pantoate--beta-alanine ligase; Region: panC; TIGR00018
608538001796	active site
608538001797	ATP-binding site [chemical binding]; other site
608538001798	pantoate-binding site; other site
608538001799	HXXH motif; other site
608538001800	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
608538001801	homopentamer interface [polypeptide binding]; other site
608538001802	active site
608538001803	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
608538001804	putative RNA binding site [nucleotide binding]; other site
608538001805	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
608538001806	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
608538001807	catalytic residues [active]
608538001808	RNA polymerase sigma factor; Provisional; Region: PRK11924
608538001809	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538001810	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538001811	DNA binding residues [nucleotide binding]
608538001812	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
608538001813	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538001814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
608538001815	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
608538001816	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
608538001817	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538001818	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
608538001819	hypothetical protein; Provisional; Region: PRK10557
608538001820	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538001821	radical SAM protein, TIGR01212 family; Region: TIGR01212
608538001822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001823	FeS/SAM binding site; other site
608538001824	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
608538001825	Cation efflux family; Region: Cation_efflux; cl00316
608538001826	dihydroorotase; Validated; Region: pyrC; PRK09357
608538001827	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
608538001828	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
608538001829	active site
608538001830	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
608538001831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538001832	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
608538001833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
608538001834	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
608538001835	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
608538001836	Bacterial sugar transferase; Region: Bac_transf; cl00939
608538001837	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
608538001838	tetramerization interface [polypeptide binding]; other site
608538001839	active site
608538001840	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
608538001841	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
608538001842	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
608538001843	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
608538001844	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538001845	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
608538001846	Maf-like protein; Region: Maf; pfam02545
608538001847	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
608538001848	active site
608538001849	dimer interface [polypeptide binding]; other site
608538001850	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
608538001851	Protein export membrane protein; Region: SecD_SecF; cl14618
608538001852	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538001853	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
608538001854	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538001855	magnesium-transporting ATPase; Provisional; Region: PRK15122
608538001856	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
608538001857	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538001858	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538001859	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538001860	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538001861	Domain of unknown function DUF59; Region: DUF59; cl00941
608538001862	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538001863	CPxP  motif; other site
608538001864	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
608538001865	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
608538001866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001867	S-adenosylmethionine binding site [chemical binding]; other site
608538001868	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
608538001869	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
608538001870	active site
608538001871	(T/H)XGH motif; other site
608538001872	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538001873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
608538001874	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538001875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538001876	active site
608538001877	phosphorylation site [posttranslational modification]
608538001878	intermolecular recognition site; other site
608538001879	dimerization interface [polypeptide binding]; other site
608538001880	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538001881	DNA binding site [nucleotide binding]
608538001882	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
608538001883	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538001884	active site
608538001885	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
608538001886	substrate binding site [chemical binding]; other site
608538001887	ribosome recycling factor; Reviewed; Region: frr; PRK00083
608538001888	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
608538001889	hinge region; other site
608538001890	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
608538001891	putative nucleotide binding site [chemical binding]; other site
608538001892	uridine monophosphate binding site [chemical binding]; other site
608538001893	homohexameric interface [polypeptide binding]; other site
608538001894	elongation factor Ts; Provisional; Region: tsf; PRK09377
608538001895	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
608538001896	Elongation factor TS; Region: EF_TS; pfam00889
608538001897	Elongation factor TS; Region: EF_TS; pfam00889
608538001898	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
608538001899	rRNA interaction site [nucleotide binding]; other site
608538001900	S8 interaction site; other site
608538001901	putative laminin-1 binding site; other site
608538001902	Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281
608538001903	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
608538001904	dimerization interface [polypeptide binding]; other site
608538001905	domain crossover interface; other site
608538001906	redox-dependent activation switch; other site
608538001907	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
608538001908	UbiA prenyltransferase family; Region: UbiA; cl00337
608538001909	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538001910	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
608538001911	nucleoside/Zn binding site; other site
608538001912	dimer interface [polypeptide binding]; other site
608538001913	catalytic motif [active]
608538001914	lipoyl synthase; Provisional; Region: PRK12928
608538001915	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001916	FeS/SAM binding site; other site
608538001917	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
608538001918	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
608538001919	Substrate binding site; other site
608538001920	Cupin domain; Region: Cupin_2; cl09118
608538001921	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
608538001922	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
608538001923	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
608538001924	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
608538001925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538001926	RNA binding surface [nucleotide binding]; other site
608538001927	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
608538001928	active site
608538001929	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
608538001930	exonuclease SbcC; Region: sbcc; TIGR00618
608538001931	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
608538001932	Walker A/P-loop; other site
608538001933	ATP binding site [chemical binding]; other site
608538001934	Q-loop/lid; other site
608538001935	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
608538001936	ABC transporter signature motif; other site
608538001937	Walker B; other site
608538001938	D-loop; other site
608538001939	H-loop/switch region; other site
608538001940	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
608538001941	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
608538001942	active site
608538001943	metal binding site [ion binding]; metal-binding site
608538001944	DNA binding site [nucleotide binding]
608538001945	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
608538001946	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
608538001947	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
608538001948	KOW motif; Region: KOW; cl00354
608538001949	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
608538001950	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
608538001951	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
608538001952	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
608538001953	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
608538001954	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
608538001955	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
608538001956	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
608538001957	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
608538001958	23S rRNA interface [nucleotide binding]; other site
608538001959	5S rRNA interface [nucleotide binding]; other site
608538001960	L27 interface [polypeptide binding]; other site
608538001961	L5 interface [polypeptide binding]; other site
608538001962	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
608538001963	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
608538001964	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
608538001965	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
608538001966	23S rRNA binding site [nucleotide binding]; other site
608538001967	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
608538001968	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
608538001969	SecY translocase; Region: SecY; pfam00344
608538001970	adenylate kinase; Reviewed; Region: adk; PRK00279
608538001971	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
608538001972	AMP-binding site [chemical binding]; other site
608538001973	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
608538001974	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
608538001975	active site
608538001976	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
608538001977	rRNA binding site [nucleotide binding]; other site
608538001978	predicted 30S ribosome binding site; other site
608538001979	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
608538001980	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
608538001981	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
608538001982	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
608538001983	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
608538001984	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538001985	RNA binding surface [nucleotide binding]; other site
608538001986	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
608538001987	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
608538001988	alphaNTD homodimer interface [polypeptide binding]; other site
608538001989	alphaNTD - beta interaction site [polypeptide binding]; other site
608538001990	alphaNTD - beta' interaction site [polypeptide binding]; other site
608538001991	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
608538001992	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
608538001993	YGGT family; Region: YGGT; cl00508
608538001994	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
608538001995	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538001996	RNA binding surface [nucleotide binding]; other site
608538001997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001998	S-adenosylmethionine binding site [chemical binding]; other site
608538001999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
608538002000	active site
608538002001	phosphorylation site [posttranslational modification]
608538002002	intermolecular recognition site; other site
608538002003	dimerization interface [polypeptide binding]; other site
608538002004	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
608538002005	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
608538002006	Catalytic site [active]
608538002007	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
608538002008	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
608538002009	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14467
608538002010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002011	FeS/SAM binding site; other site
608538002012	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538002013	MoaE interaction surface [polypeptide binding]; other site
608538002014	MoeB interaction surface [polypeptide binding]; other site
608538002015	thiocarboxylated glycine; other site
608538002016	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538002017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002018	S-adenosylmethionine binding site [chemical binding]; other site
608538002019	excinuclease ABC subunit B; Provisional; Region: PRK05298
608538002020	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538002021	ATP binding site [chemical binding]; other site
608538002022	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538002023	nucleotide binding region [chemical binding]; other site
608538002024	ATP-binding site [chemical binding]; other site
608538002025	Ultra-violet resistance protein B; Region: UvrB; pfam12344
608538002026	UvrB/uvrC motif; Region: UVR; pfam02151
608538002027	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
608538002028	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538002029	minor groove reading motif; other site
608538002030	helix-hairpin-helix signature motif; other site
608538002031	substrate binding pocket [chemical binding]; other site
608538002032	active site
608538002033	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
608538002034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002035	S-adenosylmethionine binding site [chemical binding]; other site
608538002036	spermidine synthase; Provisional; Region: PRK00811
608538002037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002038	S-adenosylmethionine binding site [chemical binding]; other site
608538002039	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
608538002040	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
608538002041	active site
608538002042	HIGH motif; other site
608538002043	KMSKS motif; other site
608538002044	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
608538002045	anticodon binding site; other site
608538002046	tRNA binding surface [nucleotide binding]; other site
608538002047	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
608538002048	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538002049	metal binding triad; other site
608538002050	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
608538002051	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538002052	metal binding triad; other site
608538002053	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
608538002054	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
608538002055	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
608538002056	putative metal binding site; other site
608538002057	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
608538002058	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
608538002059	poxB regulator PoxA; Provisional; Region: PRK09350
608538002060	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
608538002061	motif 1; other site
608538002062	dimer interface [polypeptide binding]; other site
608538002063	active site
608538002064	motif 2; other site
608538002065	motif 3; other site
608538002066	nickel responsive regulator; Provisional; Region: PRK00630
608538002067	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
608538002068	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
608538002069	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
608538002070	dimer interface [polypeptide binding]; other site
608538002071	catalytic triad [active]
608538002072	peroxidatic and resolving cysteines [active]
608538002073	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
608538002074	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
608538002075	active site
608538002076	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538002077	dimer interface [polypeptide binding]; other site
608538002078	substrate binding site [chemical binding]; other site
608538002079	catalytic residues [active]
608538002080	aconitate hydratase; Validated; Region: PRK07229
608538002081	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
608538002082	substrate binding site [chemical binding]; other site
608538002083	ligand binding site [chemical binding]; other site
608538002084	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
608538002085	substrate binding site [chemical binding]; other site
608538002086	malate dehydrogenase; Reviewed; Region: PRK06223
608538002087	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
608538002088	NAD(P) binding site [chemical binding]; other site
608538002089	dimer interface [polypeptide binding]; other site
608538002090	tetramer (dimer of dimers) interface [polypeptide binding]; other site
608538002091	substrate binding site [chemical binding]; other site
608538002092	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
608538002093	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
608538002094	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
608538002095	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
608538002096	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538002097	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
608538002098	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
608538002099	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
608538002100	active site
608538002101	homotetramer interface [polypeptide binding]; other site
608538002102	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538002103	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
608538002104	Active_site [active]
608538002105	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
608538002106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002107	FeS/SAM binding site; other site
608538002108	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
608538002109	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
608538002110	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
608538002111	trimer interface [polypeptide binding]; other site
608538002112	active site
608538002113	UDP-GlcNAc binding site [chemical binding]; other site
608538002114	lipid binding site [chemical binding]; lipid-binding site
608538002115	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
608538002116	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
608538002117	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
608538002118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002119	Walker A motif; other site
608538002120	ATP binding site [chemical binding]; other site
608538002121	Walker B motif; other site
608538002122	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
608538002123	Clp protease; Region: CLP_protease; pfam00574
608538002124	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
608538002125	oligomer interface [polypeptide binding]; other site
608538002126	active site residues [active]
608538002127	trigger factor; Region: tig; TIGR00115
608538002128	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
608538002129	anthranilate synthase component I; Provisional; Region: PRK13565
608538002130	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
608538002131	chorismate binding enzyme; Region: Chorismate_bind; cl10555
608538002132	N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338
608538002133	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002134	S-adenosylmethionine binding site [chemical binding]; other site
608538002135	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
608538002136	substrate binding site [chemical binding]; other site
608538002137	active site
608538002138	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538002139	phosphoglycolate phosphatase; Provisional; Region: PRK13222
608538002140	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538002141	motif II; other site
608538002142	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
608538002143	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
608538002144	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
608538002145	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
608538002146	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
608538002147	Zn2+ binding site [ion binding]; other site
608538002148	Mg2+ binding site [ion binding]; other site
608538002149	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
608538002150	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002151	Survival protein SurE; Region: SurE; cl00448
608538002152	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
608538002153	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
608538002154	dimerization interface [polypeptide binding]; other site
608538002155	ATP binding site [chemical binding]; other site
608538002156	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
608538002157	dimerization interface [polypeptide binding]; other site
608538002158	ATP binding site [chemical binding]; other site
608538002159	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
608538002160	lipoprotein signal peptidase; Provisional; Region: PRK14787
608538002161	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
608538002162	recombinase A; Provisional; Region: recA; PRK09354
608538002163	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
608538002164	hexamer interface [polypeptide binding]; other site
608538002165	Walker A motif; other site
608538002166	ATP binding site [chemical binding]; other site
608538002167	Walker B motif; other site
608538002168	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
608538002169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002170	Walker A motif; other site
608538002171	ATP binding site [chemical binding]; other site
608538002172	Walker B motif; other site
608538002173	cytidylate kinase; Provisional; Region: cmk; PRK00023
608538002174	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
608538002175	CMP-binding site; other site
608538002176	The sites determining sugar specificity; other site
608538002177	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
608538002178	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
608538002179	NAD(P) binding site [chemical binding]; other site
608538002180	catalytic residues [active]
608538002181	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
608538002182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
608538002183	DNA binding residues [nucleotide binding]
608538002184	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
608538002185	thiamine phosphate binding site [chemical binding]; other site
608538002186	active site
608538002187	pyrophosphate binding site [ion binding]; other site
608538002188	5'-3' exonuclease; Region: 53EXOc; smart00475
608538002189	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
608538002190	active site
608538002191	metal binding site 1 [ion binding]; metal-binding site
608538002192	putative 5' ssDNA interaction site; other site
608538002193	metal binding site 3; metal-binding site
608538002194	metal binding site 2 [ion binding]; metal-binding site
608538002195	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
608538002196	putative DNA binding site [nucleotide binding]; other site
608538002197	putative metal binding site [ion binding]; other site
608538002198	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
608538002199	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538002200	active site
608538002201	NTP binding site [chemical binding]; other site
608538002202	metal binding triad [ion binding]; metal-binding site
608538002203	antibiotic binding site [chemical binding]; other site
608538002204	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
608538002205	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
608538002206	dimer interface [polypeptide binding]; other site
608538002207	active site residues [active]
608538002208	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
608538002209	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
608538002210	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
608538002211	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
608538002212	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
608538002213	dimer interface [polypeptide binding]; other site
608538002214	active site
608538002215	CoA binding pocket [chemical binding]; other site
608538002216	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
608538002217	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
608538002218	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538002219	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538002220	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538002221	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538002222	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
608538002223	DEAD-like helicases superfamily; Region: DEXDc; smart00487
608538002224	ATP binding site [chemical binding]; other site
608538002225	Mg++ binding site [ion binding]; other site
608538002226	motif III; other site
608538002227	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538002228	nucleotide binding region [chemical binding]; other site
608538002229	ATP-binding site [chemical binding]; other site
608538002230	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
608538002231	sulfite oxidase; Provisional; Region: PLN00177
608538002232	Moco binding site; other site
608538002233	metal coordination site [ion binding]; other site
608538002234	Cytochrome c; Region: Cytochrom_C; cl11414
608538002235	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
608538002236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002237	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
608538002238	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
608538002239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538002240	Helix-turn-helix domains; Region: HTH; cl00088
608538002241	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
608538002242	intersubunit interface [polypeptide binding]; other site
608538002243	active site
608538002244	catalytic residue [active]
608538002245	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538002246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538002247	2-isopropylmalate synthase; Validated; Region: PRK00915
608538002248	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
608538002249	active site
608538002250	catalytic residues [active]
608538002251	metal binding site [ion binding]; metal-binding site
608538002252	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
608538002253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
608538002254	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
608538002255	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002256	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
608538002257	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
608538002258	iron-sulfur cluster [ion binding]; other site
608538002259	[2Fe-2S] cluster binding site [ion binding]; other site
608538002260	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
608538002261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002262	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002263	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
608538002264	thiamine phosphate binding site [chemical binding]; other site
608538002265	active site
608538002266	pyrophosphate binding site [ion binding]; other site
608538002267	integral membrane protein MviN; Region: mviN; TIGR01695
608538002268	MatE; Region: MatE; cl10513
608538002269	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
608538002270	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
608538002271	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
608538002272	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
608538002273	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002274	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538002275	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
608538002276	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538002277	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
608538002278	IMP binding site; other site
608538002279	dimer interface [polypeptide binding]; other site
608538002280	interdomain contacts; other site
608538002281	partial ornithine binding site; other site
608538002282	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002284	active site
608538002285	phosphorylation site [posttranslational modification]
608538002286	intermolecular recognition site; other site
608538002287	dimerization interface [polypeptide binding]; other site
608538002288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002289	Walker A motif; other site
608538002290	ATP binding site [chemical binding]; other site
608538002291	Walker B motif; other site
608538002292	arginine finger; other site
608538002293	Helix-turn-helix domains; Region: HTH; cl00088
608538002294	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
608538002295	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
608538002296	homodimer interface [polypeptide binding]; other site
608538002297	metal binding site [ion binding]; metal-binding site
608538002298	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529
608538002299	homodimer interface [polypeptide binding]; other site
608538002300	active site
608538002301	putative chemical substrate binding site [chemical binding]; other site
608538002302	metal binding site [ion binding]; metal-binding site
608538002303	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
608538002304	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
608538002305	ATP binding site [chemical binding]; other site
608538002306	substrate interface [chemical binding]; other site
608538002307	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
608538002308	heterotetramer interface [polypeptide binding]; other site
608538002309	active site pocket [active]
608538002310	cleavage site
608538002311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
608538002312	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
608538002313	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
608538002314	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538002315	dimer interface [polypeptide binding]; other site
608538002316	phosphorylation site [posttranslational modification]
608538002317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002318	ATP binding site [chemical binding]; other site
608538002319	Mg2+ binding site [ion binding]; other site
608538002320	G-X-G motif; other site
608538002321	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
608538002322	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
608538002323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002324	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
608538002325	DNA gyrase subunit A; Validated; Region: PRK05560
608538002326	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
608538002327	CAP-like domain; other site
608538002328	active site
608538002329	primary dimer interface [polypeptide binding]; other site
608538002330	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002331	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002332	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002333	Competence protein; Region: Competence; cl00471
608538002334	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
608538002335	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002336	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002337	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
608538002338	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
608538002339	Walker A/P-loop; other site
608538002340	ATP binding site [chemical binding]; other site
608538002341	Q-loop/lid; other site
608538002342	ABC transporter signature motif; other site
608538002343	Walker B; other site
608538002344	D-loop; other site
608538002345	H-loop/switch region; other site
608538002346	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
608538002347	putative carbohydrate binding site [chemical binding]; other site
608538002348	isocitrate dehydrogenase; Validated; Region: PRK06451
608538002349	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
608538002350	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
608538002351	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538002352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002353	S-adenosylmethionine binding site [chemical binding]; other site
608538002354	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
608538002355	AP endonuclease family 2; Region: AP2Ec; smart00518
608538002356	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
608538002357	AP (apurinic/apyrimidinic) site pocket; other site
608538002358	DNA interaction; other site
608538002359	Metal-binding active site; metal-binding site
608538002360	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
608538002361	DHH family; Region: DHH; pfam01368
608538002362	DHHA1 domain; Region: DHHA1; pfam02272
608538002363	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
608538002364	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
608538002365	HIGH motif; other site
608538002366	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
608538002367	active site
608538002368	KMSKS motif; other site
608538002369	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
608538002370	tRNA binding surface [nucleotide binding]; other site
608538002371	anticodon binding site; other site
608538002372	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
608538002373	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
608538002374	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
608538002375	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
608538002376	23S rRNA interface [nucleotide binding]; other site
608538002377	5S rRNA interface [nucleotide binding]; other site
608538002378	putative antibiotic binding site [chemical binding]; other site
608538002379	L25 interface [polypeptide binding]; other site
608538002380	L27 interface [polypeptide binding]; other site
608538002381	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
608538002382	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
608538002383	G-X-X-G motif; other site
608538002384	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
608538002385	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
608538002386	putative translocon binding site; other site
608538002387	protein-rRNA interface [nucleotide binding]; other site
608538002388	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
608538002389	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
608538002390	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
608538002391	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
608538002392	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
608538002393	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
608538002394	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
608538002395	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
608538002396	elongation factor Tu; Reviewed; Region: PRK00049
608538002397	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
608538002398	G1 box; other site
608538002399	GEF interaction site [polypeptide binding]; other site
608538002400	GTP/Mg2+ binding site [chemical binding]; other site
608538002401	Switch I region; other site
608538002402	G2 box; other site
608538002403	G3 box; other site
608538002404	Switch II region; other site
608538002405	G4 box; other site
608538002406	G5 box; other site
608538002407	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
608538002408	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
608538002409	Antibiotic Binding Site [chemical binding]; other site
608538002410	elongation factor G; Reviewed; Region: PRK00007
608538002411	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
608538002412	G1 box; other site
608538002413	putative GEF interaction site [polypeptide binding]; other site
608538002414	GTP/Mg2+ binding site [chemical binding]; other site
608538002415	Switch I region; other site
608538002416	G2 box; other site
608538002417	G3 box; other site
608538002418	Switch II region; other site
608538002419	G4 box; other site
608538002420	G5 box; other site
608538002421	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
608538002422	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
608538002423	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
608538002424	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
608538002425	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
608538002426	S17 interaction site [polypeptide binding]; other site
608538002427	S8 interaction site; other site
608538002428	16S rRNA interaction site [nucleotide binding]; other site
608538002429	streptomycin interaction site [chemical binding]; other site
608538002430	23S rRNA interaction site [nucleotide binding]; other site
608538002431	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
608538002432	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
608538002433	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
608538002434	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
608538002435	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
608538002436	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
608538002437	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
608538002438	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
608538002439	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
608538002440	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
608538002441	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
608538002442	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
608538002443	DNA binding site [nucleotide binding]
608538002444	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
608538002445	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
608538002446	DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013
608538002447	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
608538002448	RPB12 interaction site [polypeptide binding]; other site
608538002449	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
608538002450	RPB11 interaction site [polypeptide binding]; other site
608538002451	RPB12 interaction site [polypeptide binding]; other site
608538002452	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
608538002453	RPB12 interaction site [polypeptide binding]; other site
608538002454	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
608538002455	RPB1 interaction site [polypeptide binding]; other site
608538002456	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
608538002457	core dimer interface [polypeptide binding]; other site
608538002458	peripheral dimer interface [polypeptide binding]; other site
608538002459	L10 interface [polypeptide binding]; other site
608538002460	L11 interface [polypeptide binding]; other site
608538002461	putative EF-Tu interaction site [polypeptide binding]; other site
608538002462	putative EF-G interaction site [polypeptide binding]; other site
608538002463	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
608538002464	23S rRNA interface [nucleotide binding]; other site
608538002465	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
608538002466	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
608538002467	mRNA/rRNA interface [nucleotide binding]; other site
608538002468	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
608538002469	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
608538002470	23S rRNA interface [nucleotide binding]; other site
608538002471	L7/L12 interface [polypeptide binding]; other site
608538002472	putative thiostrepton binding site; other site
608538002473	L25 interface [polypeptide binding]; other site
608538002474	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
608538002475	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
608538002476	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
608538002477	putative homodimer interface [polypeptide binding]; other site
608538002478	KOW motif; Region: KOW; cl00354
608538002479	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
608538002480	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
608538002481	elongation factor Tu; Reviewed; Region: PRK00049
608538002482	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
608538002483	G1 box; other site
608538002484	GEF interaction site [polypeptide binding]; other site
608538002485	GTP/Mg2+ binding site [chemical binding]; other site
608538002486	Switch I region; other site
608538002487	G2 box; other site
608538002488	G3 box; other site
608538002489	Switch II region; other site
608538002490	G4 box; other site
608538002491	G5 box; other site
608538002492	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
608538002493	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
608538002494	Antibiotic Binding Site [chemical binding]; other site
608538002495	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
608538002496	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
608538002497	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
608538002498	active site
608538002499	dimer interface [polypeptide binding]; other site
608538002500	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
608538002501	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
608538002502	active site
608538002503	FMN binding site [chemical binding]; other site
608538002504	substrate binding site [chemical binding]; other site
608538002505	3Fe-4S cluster binding site [ion binding]; other site
608538002506	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
608538002507	domain interface; other site
608538002508	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
608538002509	active site
608538002510	dimer interface [polypeptide binding]; other site
608538002511	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
608538002512	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
608538002513	putative active site [active]
608538002514	oxyanion strand; other site
608538002515	catalytic triad [active]
608538002516	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
608538002517	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538002518	catalytic residues [active]
608538002519	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538002520	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538002521	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
608538002522	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
608538002523	DNA binding residues [nucleotide binding]
608538002524	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
608538002525	catalytic residues [active]
608538002526	catalytic nucleophile [active]
608538002527	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
608538002528	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
608538002529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
608538002530	Terminase-like family; Region: Terminase_6; pfam03237
608538002531	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
608538002532	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
608538002533	cell surface protein SprA; Region: surface_SprA; TIGR04189
608538002534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538002535	non-specific DNA binding site [nucleotide binding]; other site
608538002536	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
608538002537	salt bridge; other site
608538002538	sequence-specific DNA binding site [nucleotide binding]; other site
608538002539	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
608538002540	Catalytic site [active]
608538002541	ParB-like nuclease domain; Region: ParBc; cl02129
608538002542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
608538002543	Helix-turn-helix domains; Region: HTH; cl00088
608538002544	Integrase core domain; Region: rve; cl01316
608538002545	AAA domain; Region: AAA_22; pfam13401
608538002546	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
608538002547	Phage capsid family; Region: Phage_capsid; pfam05065
608538002548	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
608538002549	hypothetical protein; Region: PHA01756
608538002550	GAF domain; Region: GAF_2; pfam13185
608538002551	GAF domain; Region: GAF; cl15785
608538002552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538002553	PAS domain; Region: PAS_9; pfam13426
608538002554	putative active site [active]
608538002555	heme pocket [chemical binding]; other site
608538002556	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538002557	metal binding site [ion binding]; metal-binding site
608538002558	active site
608538002559	I-site; other site
608538002560	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
608538002561	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
608538002562	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
608538002563	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
608538002564	[4Fe-4S] binding site [ion binding]; other site
608538002565	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538002566	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538002567	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
608538002568	molybdopterin cofactor binding site; other site
608538002569	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
608538002570	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
608538002571	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
608538002572	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
608538002573	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
608538002574	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
608538002575	E-class dimer interface [polypeptide binding]; other site
608538002576	P-class dimer interface [polypeptide binding]; other site
608538002577	active site
608538002578	Cu2+ binding site [ion binding]; other site
608538002579	Zn2+ binding site [ion binding]; other site
608538002580	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
608538002581	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
608538002582	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538002583	lipoyl attachment site [posttranslational modification]; other site
608538002584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
608538002585	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
608538002586	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
608538002587	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
608538002588	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002589	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
608538002590	FtsX-like permease family; Region: FtsX; cl15850
608538002591	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002592	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
608538002593	Walker A/P-loop; other site
608538002594	ATP binding site [chemical binding]; other site
608538002595	Q-loop/lid; other site
608538002596	ABC transporter signature motif; other site
608538002597	Walker B; other site
608538002598	D-loop; other site
608538002599	H-loop/switch region; other site
608538002600	macrolide transporter subunit MacA; Provisional; Region: PRK11578
608538002601	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538002602	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
608538002603	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538002604	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538002605	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
608538002606	active site
608538002607	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
608538002608	active site
608538002609	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
608538002610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002611	FeS/SAM binding site; other site
608538002612	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
608538002613	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538002614	D-pathway; other site
608538002615	Low-spin heme binding site [chemical binding]; other site
608538002616	Putative water exit pathway; other site
608538002617	Binuclear center (active site) [active]
608538002618	K-pathway; other site
608538002619	Putative proton exit pathway; other site
608538002620	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
608538002621	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
608538002622	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538002623	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538002624	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
608538002625	Subunit I/III interface [polypeptide binding]; other site
608538002626	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
608538002627	ligand binding site [chemical binding]; other site
608538002628	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
608538002629	putative active site [active]
608538002630	dimerization interface [polypeptide binding]; other site
608538002631	putative tRNAtyr binding site [nucleotide binding]; other site
608538002632	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
608538002633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002634	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
608538002635	cysteine synthase B; Region: cysM; TIGR01138
608538002636	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
608538002637	dimer interface [polypeptide binding]; other site
608538002638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002639	catalytic residue [active]
608538002640	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
608538002641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538002643	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
608538002644	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538002645	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538002646	putative active site [active]
608538002647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538002648	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
608538002649	ATP synthase; Region: ATP-synt; cl00365
608538002650	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
608538002651	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
608538002652	active site
608538002653	HIGH motif; other site
608538002654	dimer interface [polypeptide binding]; other site
608538002655	KMSKS motif; other site
608538002656	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
608538002657	trimer interface [polypeptide binding]; other site
608538002658	active site
608538002659	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
608538002660	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002661	FtsX-like permease family; Region: FtsX; cl15850
608538002662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002663	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
608538002664	Walker A/P-loop; other site
608538002665	ATP binding site [chemical binding]; other site
608538002666	Q-loop/lid; other site
608538002667	ABC transporter signature motif; other site
608538002668	Walker B; other site
608538002669	D-loop; other site
608538002670	H-loop/switch region; other site
608538002671	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
608538002672	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
608538002673	Ligand binding site; other site
608538002674	Putative Catalytic site; other site
608538002675	DXD motif; other site
608538002676	Protein of unknown function (DUF523); Region: DUF523; cl00733
608538002677	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
608538002678	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
608538002679	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
608538002680	CoA-binding site [chemical binding]; other site
608538002681	ATP-binding [chemical binding]; other site
608538002682	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
608538002683	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538002684	Cysteine-rich domain; Region: CCG; pfam02754
608538002685	Cysteine-rich domain; Region: CCG; pfam02754
608538002686	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
608538002687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002688	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002689	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538002690	PAS domain; Region: PAS_9; pfam13426
608538002691	putative active site [active]
608538002692	heme pocket [chemical binding]; other site
608538002693	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538002694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002695	ATP binding site [chemical binding]; other site
608538002696	Mg2+ binding site [ion binding]; other site
608538002697	G-X-G motif; other site
608538002698	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002700	active site
608538002701	phosphorylation site [posttranslational modification]
608538002702	intermolecular recognition site; other site
608538002703	dimerization interface [polypeptide binding]; other site
608538002704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002705	Walker A motif; other site
608538002706	ATP binding site [chemical binding]; other site
608538002707	Walker B motif; other site
608538002708	arginine finger; other site
608538002709	GTPase Era; Reviewed; Region: era; PRK00089
608538002710	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
608538002711	G1 box; other site
608538002712	GTP/Mg2+ binding site [chemical binding]; other site
608538002713	Switch I region; other site
608538002714	G2 box; other site
608538002715	Switch II region; other site
608538002716	G3 box; other site
608538002717	G4 box; other site
608538002718	G5 box; other site
608538002719	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
608538002720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538002721	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
608538002722	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
608538002723	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
608538002724	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
608538002725	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
608538002726	MPT binding site; other site
608538002727	trimer interface [polypeptide binding]; other site
608538002728	enolase; Provisional; Region: eno; PRK00077
608538002729	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
608538002730	dimer interface [polypeptide binding]; other site
608538002731	metal binding site [ion binding]; metal-binding site
608538002732	substrate binding pocket [chemical binding]; other site
608538002733	Septum formation initiator; Region: DivIC; cl11433
608538002734	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
608538002735	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
608538002736	catalytic motif [active]
608538002737	Zn binding site [ion binding]; other site
608538002738	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
608538002739	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
608538002740	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
608538002741	putative active site [active]
608538002742	substrate binding site [chemical binding]; other site
608538002743	putative cosubstrate binding site; other site
608538002744	catalytic site [active]
608538002745	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
608538002746	substrate binding site [chemical binding]; other site
608538002747	Protein of unknown function DUF86; Region: DUF86; cl01031
608538002748	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
608538002749	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
608538002750	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
608538002751	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
608538002752	NifU-like domain; Region: NifU; cl00484
608538002753	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
608538002754	RimM N-terminal domain; Region: RimM; pfam01782
608538002755	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
608538002756	Cytochrome c; Region: Cytochrom_C; cl11414
608538002757	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
608538002758	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538002759	Peptidase family M48; Region: Peptidase_M48; cl12018
608538002760	TPR repeat; Region: TPR_11; pfam13414
608538002761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538002762	TPR motif; other site
608538002763	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538002764	binding surface
608538002765	Protein phosphatase 2C; Region: PP2C; pfam00481
608538002766	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
608538002767	active site
608538002768	hypothetical protein; Provisional; Region: PRK04328
608538002769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002770	Walker A motif; other site
608538002771	ATP binding site [chemical binding]; other site
608538002772	Walker B motif; other site
608538002773	NlpC/P60 family; Region: NLPC_P60; cl11438
608538002774	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
608538002775	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
608538002776	active site residue [active]
608538002777	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002778	DsrE/DsrF-like family; Region: DrsE; cl00672
608538002779	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
608538002780	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
608538002781	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
608538002782	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538002783	catalytic residue [active]
608538002784	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
608538002785	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538002786	inhibitor-cofactor binding pocket; inhibition site
608538002787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002788	catalytic residue [active]
608538002789	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
608538002790	CrcB-like protein; Region: CRCB; cl09114
608538002791	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
608538002792	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538002793	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538002794	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538002795	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538002796	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
608538002797	dimerization interface [polypeptide binding]; other site
608538002798	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
608538002799	ATP binding site [chemical binding]; other site
608538002800	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
608538002801	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
608538002802	Acylphosphatase; Region: Acylphosphatase; cl00551
608538002803	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
608538002804	HypF finger; Region: zf-HYPF; pfam07503
608538002805	HypF finger; Region: zf-HYPF; pfam07503
608538002806	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
608538002807	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
608538002808	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538002809	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
608538002810	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
608538002811	putative substrate-binding site; other site
608538002812	nickel binding site [ion binding]; other site
608538002813	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
608538002814	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538002815	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538002816	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538002817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538002818	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
608538002819	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
608538002820	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538002821	IHF - DNA interface [nucleotide binding]; other site
608538002822	IHF dimer interface [polypeptide binding]; other site
608538002823	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
608538002824	ribosomal protein S1; Region: rpsA; TIGR00717
608538002825	RNA binding site [nucleotide binding]; other site
608538002826	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538002827	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538002828	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538002829	RNA binding site [nucleotide binding]; other site
608538002830	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538002831	RNA binding site [nucleotide binding]; other site
608538002832	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538002833	RNA binding site [nucleotide binding]; other site
608538002834	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
608538002835	hypothetical protein; Reviewed; Region: PRK09588
608538002836	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
608538002837	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
608538002838	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002839	FtsX-like permease family; Region: FtsX; cl15850
608538002840	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002841	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
608538002842	Walker A/P-loop; other site
608538002843	ATP binding site [chemical binding]; other site
608538002844	Q-loop/lid; other site
608538002845	ABC transporter signature motif; other site
608538002846	Walker B; other site
608538002847	D-loop; other site
608538002848	H-loop/switch region; other site
608538002849	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002850	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
608538002851	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002852	FtsX-like permease family; Region: FtsX; cl15850
608538002853	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002854	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
608538002855	Walker A/P-loop; other site
608538002856	ATP binding site [chemical binding]; other site
608538002857	Q-loop/lid; other site
608538002858	ABC transporter signature motif; other site
608538002859	Walker B; other site
608538002860	D-loop; other site
608538002861	H-loop/switch region; other site
608538002862	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
608538002863	FixH; Region: FixH; cl01254
608538002864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538002865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002866	ATP binding site [chemical binding]; other site
608538002867	Mg2+ binding site [ion binding]; other site
608538002868	G-X-G motif; other site
608538002869	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002871	active site
608538002872	phosphorylation site [posttranslational modification]
608538002873	intermolecular recognition site; other site
608538002874	dimerization interface [polypeptide binding]; other site
608538002875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002876	Walker A motif; other site
608538002877	ATP binding site [chemical binding]; other site
608538002878	Walker B motif; other site
608538002879	arginine finger; other site
608538002880	Helix-turn-helix domains; Region: HTH; cl00088
608538002881	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
608538002882	active site
608538002883	catalytic residues [active]
608538002884	ABC-2 type transporter; Region: ABC2_membrane; cl11417
608538002885	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
608538002886	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
608538002887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002888	catalytic residue [active]
608538002889	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
608538002890	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
608538002891	active site
608538002892	DsrE/DsrF-like family; Region: DrsE; cl00672
608538002893	DsrE/DsrF-like family; Region: DrsE; cl00672
608538002894	DsrE/DsrF-like family; Region: DrsE; cl00672
608538002895	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538002896	CPxP  motif; other site
608538002897	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
608538002898	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
608538002899	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538002900	Walker A motif; other site
608538002901	ATP binding site [chemical binding]; other site
608538002902	Walker B motif; other site
608538002903	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
608538002904	oligomerization interface [polypeptide binding]; other site
608538002905	active site
608538002906	metal binding site [ion binding]; metal-binding site
608538002907	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
608538002908	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
608538002909	HIGH motif; other site
608538002910	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
608538002911	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538002912	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538002913	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
608538002914	StbA protein; Region: StbA; pfam06406
608538002915	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
608538002916	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
608538002917	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538002918	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
608538002919	putative ADP-binding pocket [chemical binding]; other site
608538002920	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538002921	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
608538002922	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
608538002923	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
608538002924	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
608538002925	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
608538002926	active site
608538002927	HIGH motif; other site
608538002928	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
608538002929	KMSKS motif; other site
608538002930	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
608538002931	tRNA binding surface [nucleotide binding]; other site
608538002932	anticodon binding site; other site
608538002933	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
608538002934	HIGH motif; other site
608538002935	dimer interface [polypeptide binding]; other site
608538002936	glycogen synthase kinase; Provisional; Region: PTZ00036
608538002937	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
608538002938	active site
608538002939	KMSKS motif; other site
608538002940	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
608538002941	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538002942	metal binding site [ion binding]; metal-binding site
608538002943	active site
608538002944	I-site; other site
608538002945	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538002946	metal binding site [ion binding]; metal-binding site
608538002947	active site
608538002948	I-site; other site
608538002949	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
608538002950	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
608538002951	dimer interface [polypeptide binding]; other site
608538002952	FMN binding site [chemical binding]; other site
608538002953	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
608538002954	CoenzymeA binding site [chemical binding]; other site
608538002955	subunit interaction site [polypeptide binding]; other site
608538002956	PHB binding site; other site
608538002957	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
608538002958	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538002959	active site
608538002960	catalytic tetrad [active]
608538002961	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
608538002962	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
608538002963	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538002964	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538002965	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
608538002966	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
608538002967	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
608538002968	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
608538002969	active site
608538002970	FMN binding site [chemical binding]; other site
608538002971	substrate binding site [chemical binding]; other site
608538002972	homotetramer interface [polypeptide binding]; other site
608538002973	catalytic residue [active]
608538002974	Helix-turn-helix domains; Region: HTH; cl00088
608538002975	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
608538002976	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
608538002977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002978	catalytic residue [active]
608538002979	septum site-determining protein MinC; Region: minC; TIGR01222
608538002980	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
608538002981	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
608538002982	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
608538002983	P-loop; other site
608538002984	ADP binding residues [chemical binding]; other site
608538002985	Switch I; other site
608538002986	Switch II; other site
608538002987	Septum formation topological specificity factor MinE; Region: MinE; cl00538
608538002988	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538002989	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
608538002990	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538002991	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
608538002992	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
608538002993	putative active site [active]
608538002994	putative metal binding site [ion binding]; other site
608538002995	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
608538002996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538002997	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538002998	SurA N-terminal domain; Region: SurA_N_3; cl07813
608538002999	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
608538003000	PPIC-type PPIASE domain; Region: Rotamase; cl08278
608538003001	FAD binding domain; Region: FAD_binding_4; pfam01565
608538003002	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
608538003003	Protein of unknown function (DUF507); Region: DUF507; cl01112
608538003004	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
608538003005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003006	S-adenosylmethionine binding site [chemical binding]; other site
608538003007	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
608538003008	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
608538003009	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
608538003010	intersubunit interface [polypeptide binding]; other site
608538003011	active site
608538003012	Zn2+ binding site [ion binding]; other site
608538003013	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
608538003014	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
608538003015	THF binding site; other site
608538003016	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
608538003017	substrate binding site [chemical binding]; other site
608538003018	THF binding site; other site
608538003019	zinc-binding site [ion binding]; other site
608538003020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538003021	dimer interface [polypeptide binding]; other site
608538003022	phosphorylation site [posttranslational modification]
608538003023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538003024	ATP binding site [chemical binding]; other site
608538003025	Mg2+ binding site [ion binding]; other site
608538003026	G-X-G motif; other site
608538003027	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
608538003028	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
608538003029	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
608538003030	dimerization interface [polypeptide binding]; other site
608538003031	active site
608538003032	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
608538003033	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
608538003034	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003035	Walker A/P-loop; other site
608538003036	ATP binding site [chemical binding]; other site
608538003037	Q-loop/lid; other site
608538003038	ABC transporter signature motif; other site
608538003039	Walker B; other site
608538003040	D-loop; other site
608538003041	H-loop/switch region; other site
608538003042	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
608538003043	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
608538003044	homodecamer interface [polypeptide binding]; other site
608538003045	GTP cyclohydrolase I; Provisional; Region: PLN03044
608538003046	active site
608538003047	putative catalytic site residues [active]
608538003048	zinc binding site [ion binding]; other site
608538003049	GTP-CH-I/GFRP interaction surface; other site
608538003050	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538003051	active site
608538003052	KMSKS motif; other site
608538003053	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
608538003054	tRNA binding surface [nucleotide binding]; other site
608538003055	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
608538003056	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538003057	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
608538003058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
608538003059	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
608538003060	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
608538003061	TPP-binding site [chemical binding]; other site
608538003062	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
608538003063	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
608538003064	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
608538003065	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538003066	dimer interface [polypeptide binding]; other site
608538003067	PYR/PP interface [polypeptide binding]; other site
608538003068	TPP binding site [chemical binding]; other site
608538003069	substrate binding site [chemical binding]; other site
608538003070	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
608538003071	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
608538003072	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538003073	dimer interface [polypeptide binding]; other site
608538003074	PYR/PP interface [polypeptide binding]; other site
608538003075	TPP binding site [chemical binding]; other site
608538003076	substrate binding site [chemical binding]; other site
608538003077	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538003078	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
608538003079	TPP-binding site [chemical binding]; other site
608538003080	dimer interface [polypeptide binding]; other site
608538003081	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
608538003082	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
608538003083	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
608538003084	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003085	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
608538003086	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538003087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
608538003088	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
608538003089	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
608538003090	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
608538003091	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538003092	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
608538003093	active site
608538003094	catalytic tetrad [active]
608538003095	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
608538003096	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
608538003097	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
608538003098	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
608538003099	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
608538003100	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
608538003101	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
608538003102	active site
608538003103	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
608538003104	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
608538003105	[4Fe-4S] binding site [ion binding]; other site
608538003106	molybdopterin cofactor binding site; other site
608538003107	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
608538003108	molybdopterin cofactor binding site; other site
608538003109	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
608538003110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538003111	putative substrate translocation pore; other site
608538003112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538003113	cyanate hydratase; Validated; Region: PRK02866
608538003114	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
608538003115	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
608538003116	oligomer interface [polypeptide binding]; other site
608538003117	active site
608538003118	Nitrogen regulatory protein P-II; Region: P-II; cl00412
608538003119	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003120	Nitrogen regulatory protein P-II; Region: P-II; cl00412
608538003121	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
608538003122	heme-binding site [chemical binding]; other site
608538003123	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
608538003124	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003125	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
608538003126	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538003127	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
608538003128	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538003129	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003130	metal-binding site [ion binding]
608538003131	Nitrogen regulatory protein P-II; Region: P-II; cl00412
608538003132	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003133	Nitrogen regulatory protein P-II; Region: P-II; cl00412
608538003134	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003135	NifT/FixU protein; Region: NifT; cl02351
608538003136	4Fe-4S binding domain; Region: Fer4; cl02805
608538003137	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
608538003138	Nitrogen fixation protein NifW; Region: NifW; cl03935
608538003139	NifZ domain; Region: NifZ; pfam04319
608538003140	TOBE domain; Region: TOBE_2; cl01440
608538003141	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538003142	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
608538003143	4Fe-4S binding domain; Region: Fer4; cl02805
608538003144	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538003145	Rop-like; Region: Rop-like; cl02247
608538003146	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
608538003147	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
608538003148	active site
608538003149	catalytic residues [active]
608538003150	metal binding site [ion binding]; metal-binding site
608538003151	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
608538003152	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003153	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003154	catalytic residue [active]
608538003155	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
608538003156	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
608538003157	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
608538003158	Nif-specific regulatory protein; Region: nifA; TIGR01817
608538003159	GAF domain; Region: GAF; cl15785
608538003160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538003161	Walker A motif; other site
608538003162	ATP binding site [chemical binding]; other site
608538003163	Walker B motif; other site
608538003164	arginine finger; other site
608538003165	Helix-turn-helix domains; Region: HTH; cl00088
608538003166	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
608538003167	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
608538003168	Nucleotide-binding sites [chemical binding]; other site
608538003169	Walker A motif; other site
608538003170	Switch I region of nucleotide binding site; other site
608538003171	Fe4S4 binding sites [ion binding]; other site
608538003172	Switch II region of nucleotide binding site; other site
608538003173	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538003174	ligand binding site [chemical binding]; other site
608538003175	flexible hinge region; other site
608538003176	Helix-turn-helix domains; Region: HTH; cl00088
608538003177	putative switch regulator; other site
608538003178	non-specific DNA interactions [nucleotide binding]; other site
608538003179	DNA binding site [nucleotide binding]
608538003180	sequence specific DNA binding site [nucleotide binding]; other site
608538003181	putative cAMP binding site [chemical binding]; other site
608538003182	Protein of unknown function, DUF269; Region: DUF269; cl03973
608538003183	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538003184	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003185	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003186	catalytic residue [active]
608538003187	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
608538003188	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
608538003189	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
608538003190	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
608538003191	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
608538003192	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
608538003193	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538003194	hydrogenase 4 subunit F; Validated; Region: PRK06458
608538003195	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538003196	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
608538003197	NADH dehydrogenase; Region: NADHdh; cl00469
608538003198	hydrogenase 4 subunit B; Validated; Region: PRK06521
608538003199	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538003200	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
608538003201	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538003202	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
608538003203	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538003204	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
608538003205	catalytic center binding site [active]
608538003206	ATP binding site [chemical binding]; other site
608538003207	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003208	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
608538003209	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003210	catalytic residue [active]
608538003211	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
608538003212	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
608538003213	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
608538003214	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003215	Walker A motif; other site
608538003216	ATP binding site [chemical binding]; other site
608538003217	Walker B motif; other site
608538003218	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
608538003219	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
608538003220	dimer interface [polypeptide binding]; other site
608538003221	active site
608538003222	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538003223	catalytic residues [active]
608538003224	substrate binding site [chemical binding]; other site
608538003225	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
608538003226	Ligand Binding Site [chemical binding]; other site
608538003227	Protein of unknown function (DUF458); Region: DUF458; cl00861
608538003228	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
608538003229	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
608538003230	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
608538003231	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
608538003232	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
608538003233	dimerization interface [polypeptide binding]; other site
608538003234	putative ATP binding site [chemical binding]; other site
608538003235	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
608538003236	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538003237	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538003238	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538003239	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538003240	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
608538003241	Surface antigen; Region: Bac_surface_Ag; cl03097
608538003242	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
608538003243	dimer interface [polypeptide binding]; other site
608538003244	substrate binding site [chemical binding]; other site
608538003245	ATP binding site [chemical binding]; other site
608538003246	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
608538003247	trimer interface [polypeptide binding]; other site
608538003248	dimer interface [polypeptide binding]; other site
608538003249	putative active site [active]
608538003250	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
608538003251	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
608538003252	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
608538003253	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
608538003254	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
608538003255	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538003256	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
608538003257	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
608538003258	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
608538003259	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003260	FeS/SAM binding site; other site
608538003261	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
608538003262	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
608538003263	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
608538003264	Cupin domain; Region: Cupin_2; cl09118
608538003265	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
608538003266	trimer interface [polypeptide binding]; other site
608538003267	active site
608538003268	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
608538003269	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
608538003270	RNase E interface [polypeptide binding]; other site
608538003271	trimer interface [polypeptide binding]; other site
608538003272	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
608538003273	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
608538003274	RNase E interface [polypeptide binding]; other site
608538003275	trimer interface [polypeptide binding]; other site
608538003276	active site
608538003277	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
608538003278	putative nucleic acid binding region [nucleotide binding]; other site
608538003279	G-X-X-G motif; other site
608538003280	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
608538003281	RNA binding site [nucleotide binding]; other site
608538003282	domain interface; other site
608538003283	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
608538003284	16S/18S rRNA binding site [nucleotide binding]; other site
608538003285	S13e-L30e interaction site [polypeptide binding]; other site
608538003286	25S rRNA binding site [nucleotide binding]; other site
608538003287	Low molecular weight phosphatase family; Region: LMWPc; cl00105
608538003288	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
608538003289	active site
608538003290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
608538003291	Helix-turn-helix domains; Region: HTH; cl00088
608538003292	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
608538003293	putative dimerization interface [polypeptide binding]; other site
608538003294	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
608538003295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538003296	motif II; other site
608538003297	Trm112p-like protein; Region: Trm112p; cl01066
608538003298	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
608538003299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003300	FeS/SAM binding site; other site
608538003301	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
608538003302	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
608538003303	MoaE homodimer interface [polypeptide binding]; other site
608538003304	MoaD interaction [polypeptide binding]; other site
608538003305	active site residues [active]
608538003306	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
608538003307	metal ion-dependent adhesion site (MIDAS); other site
608538003308	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
608538003309	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
608538003310	Walker A/P-loop; other site
608538003311	ATP binding site [chemical binding]; other site
608538003312	Q-loop/lid; other site
608538003313	ABC transporter signature motif; other site
608538003314	Walker B; other site
608538003315	D-loop; other site
608538003316	H-loop/switch region; other site
608538003317	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
608538003318	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
608538003319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003320	S-adenosylmethionine binding site [chemical binding]; other site
608538003321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538003322	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
608538003323	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538003324	Cu(I) binding site [ion binding]; other site
608538003325	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
608538003326	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
608538003327	GatB domain; Region: GatB_Yqey; cl11497
608538003328	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
608538003329	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
608538003330	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538003331	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538003332	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538003333	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
608538003334	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
608538003335	ornithine carbamoyltransferase; Provisional; Region: PRK00779
608538003336	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
608538003337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003339	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
608538003340	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
608538003341	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
608538003342	substrate binding pocket [chemical binding]; other site
608538003343	chain length determination region; other site
608538003344	substrate-Mg2+ binding site; other site
608538003345	catalytic residues [active]
608538003346	aspartate-rich region 1; other site
608538003347	active site lid residues [active]
608538003348	aspartate-rich region 2; other site
608538003349	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14667
608538003350	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
608538003351	GIY-YIG motif/motif A; other site
608538003352	active site
608538003353	catalytic site [active]
608538003354	putative DNA binding site [nucleotide binding]; other site
608538003355	metal binding site [ion binding]; metal-binding site
608538003356	UvrB/uvrC motif; Region: UVR; pfam02151
608538003357	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
608538003358	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
608538003359	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
608538003360	substrate binding pocket [chemical binding]; other site
608538003361	chain length determination region; other site
608538003362	substrate-Mg2+ binding site; other site
608538003363	catalytic residues [active]
608538003364	aspartate-rich region 1; other site
608538003365	active site lid residues [active]
608538003366	aspartate-rich region 2; other site
608538003367	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
608538003368	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538003369	catalytic residue [active]
608538003370	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
608538003371	active site
608538003372	catalytic residues [active]
608538003373	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538003374	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003375	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538003376	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
608538003377	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
608538003378	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003379	FeS/SAM binding site; other site
608538003380	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
608538003381	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
608538003382	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538003383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
608538003384	putative substrate translocation pore; other site
608538003385	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
608538003386	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
608538003387	Lipopolysaccharide-assembly; Region: LptE; cl01125
608538003388	Domain of unknown function DUF302; Region: DUF302; cl01364
608538003389	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
608538003390	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
608538003391	Ferritin-like domain; Region: Ferritin; pfam00210
608538003392	binuclear metal center [ion binding]; other site
608538003393	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538003394	Heme NO binding; Region: HNOB; cl15268
608538003395	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
608538003396	FAD binding pocket [chemical binding]; other site
608538003397	FAD binding motif [chemical binding]; other site
608538003398	phosphate binding motif [ion binding]; other site
608538003399	beta-alpha-beta structure motif; other site
608538003400	NAD binding pocket [chemical binding]; other site
608538003401	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
608538003402	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
608538003403	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
608538003404	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
608538003405	metal binding triad [ion binding]; metal-binding site
608538003406	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
608538003407	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
608538003408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
608538003409	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538003410	putative carbohydrate kinase; Provisional; Region: PRK10565
608538003411	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
608538003412	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
608538003413	putative substrate binding site [chemical binding]; other site
608538003414	putative ATP binding site [chemical binding]; other site
608538003415	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
608538003416	dihydrodipicolinate synthase; Region: dapA; TIGR00674
608538003417	dimer interface [polypeptide binding]; other site
608538003418	active site
608538003419	catalytic residue [active]
608538003420	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
608538003421	Endodeoxyribonuclease RusA; Region: RusA; cl01885
608538003422	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003423	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
608538003424	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
608538003425	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003426	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
608538003427	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003428	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538003429	Acylphosphatase; Region: Acylphosphatase; cl00551
608538003430	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
608538003431	LytB protein; Region: LYTB; cl00507
608538003432	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
608538003433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003434	FeS/SAM binding site; other site
608538003435	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538003436	Cupin domain; Region: Cupin_2; cl09118
608538003437	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
608538003438	DsrE/DsrF-like family; Region: DrsE; cl00672
608538003439	Helix-turn-helix domains; Region: HTH; cl00088
608538003440	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
608538003441	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
608538003442	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
608538003443	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
608538003444	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003445	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
608538003446	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
608538003447	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
608538003448	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
608538003449	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
608538003450	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538003451	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
608538003452	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538003453	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
608538003454	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
608538003455	prolyl-tRNA synthetase; Provisional; Region: PRK09194
608538003456	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
608538003457	dimer interface [polypeptide binding]; other site
608538003458	motif 1; other site
608538003459	active site
608538003460	motif 2; other site
608538003461	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
608538003462	putative deacylase active site [active]
608538003463	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
608538003464	active site
608538003465	motif 3; other site
608538003466	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
608538003467	anticodon binding site; other site
608538003468	AAA domain; Region: AAA_26; pfam13500
608538003469	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003470	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
608538003471	ADP binding site [chemical binding]; other site
608538003472	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
608538003473	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
608538003474	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
608538003475	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
608538003476	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
608538003477	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
608538003478	catalytic site [active]
608538003479	subunit interface [polypeptide binding]; other site
608538003480	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
608538003481	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
608538003482	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
608538003483	active site
608538003484	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
608538003485	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
608538003486	hypothetical protein; Provisional; Region: PRK11573
608538003487	Domain of unknown function DUF21; Region: DUF21; pfam01595
608538003488	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
608538003489	Transporter associated domain; Region: CorC_HlyC; cl08393
608538003490	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
608538003491	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
608538003492	Walker A/P-loop; other site
608538003493	ATP binding site [chemical binding]; other site
608538003494	Q-loop/lid; other site
608538003495	ABC transporter signature motif; other site
608538003496	Walker B; other site
608538003497	D-loop; other site
608538003498	H-loop/switch region; other site
608538003499	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
608538003500	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
608538003501	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003502	FeS/SAM binding site; other site
608538003503	HemN C-terminal domain; Region: HemN_C; pfam06969
608538003504	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
608538003505	dimer interface [polypeptide binding]; other site
608538003506	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
608538003507	Uncharacterized conserved protein [Function unknown]; Region: COG1432
608538003508	LabA_like proteins; Region: LabA; cd10911
608538003509	putative metal binding site [ion binding]; other site
608538003510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003511	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
608538003512	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
608538003513	hypothetical protein; Provisional; Region: PRK08609
608538003514	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
608538003515	active site
608538003516	primer binding site [nucleotide binding]; other site
608538003517	NTP  binding site [chemical binding]; other site
608538003518	metal binding triad [ion binding]; metal-binding site
608538003519	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
608538003520	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
608538003521	domain interfaces; other site
608538003522	active site
608538003523	HerA helicase [Replication, recombination, and repair]; Region: COG0433
608538003524	AMIN domain; Region: AMIN; pfam11741
608538003525	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
608538003526	active site
608538003527	metal binding site [ion binding]; metal-binding site
608538003528	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
608538003529	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003530	FeS/SAM binding site; other site
608538003531	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
608538003532	translation initiation factor IF-2; Region: IF-2; TIGR00487
608538003533	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
608538003534	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
608538003535	G1 box; other site
608538003536	putative GEF interaction site [polypeptide binding]; other site
608538003537	GTP/Mg2+ binding site [chemical binding]; other site
608538003538	Switch I region; other site
608538003539	G2 box; other site
608538003540	G3 box; other site
608538003541	Switch II region; other site
608538003542	G4 box; other site
608538003543	G5 box; other site
608538003544	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
608538003545	Translation-initiation factor 2; Region: IF-2; pfam11987
608538003546	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
608538003547	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
608538003548	biotin synthase; Region: bioB; TIGR00433
608538003549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003550	FeS/SAM binding site; other site
608538003551	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
608538003552	Protein of unknown function (DUF328); Region: DUF328; cl01143
608538003553	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
608538003554	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
608538003555	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003556	Ligand Binding Site [chemical binding]; other site
608538003557	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003558	Ligand Binding Site [chemical binding]; other site
608538003559	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
608538003560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538003561	ATP binding site [chemical binding]; other site
608538003562	Mg2+ binding site [ion binding]; other site
608538003563	G-X-G motif; other site
608538003564	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
608538003565	anchoring element; other site
608538003566	dimer interface [polypeptide binding]; other site
608538003567	ATP binding site [chemical binding]; other site
608538003568	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
608538003569	active site
608538003570	putative metal-binding site [ion binding]; other site
608538003571	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
608538003572	Predicted methyltransferases [General function prediction only]; Region: COG1568
608538003573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003575	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538003576	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538003577	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538003578	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538003579	Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031
608538003580	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538003581	protein binding site [polypeptide binding]; other site
608538003582	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
608538003583	active site
608538003584	HslU subunit interaction site [polypeptide binding]; other site
608538003585	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
608538003586	Putative zinc ribbon domain; Region: DUF164; pfam02591
608538003587	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
608538003588	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
608538003589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003590	FeS/SAM binding site; other site
608538003591	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
608538003592	intersubunit interface [polypeptide binding]; other site
608538003593	active site
608538003594	Zn2+ binding site [ion binding]; other site
608538003595	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538003596	lipoyl attachment site [posttranslational modification]; other site
608538003597	selenocysteine synthase; Provisional; Region: PRK04311
608538003598	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003599	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
608538003600	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
608538003601	G1 box; other site
608538003602	putative GEF interaction site [polypeptide binding]; other site
608538003603	GTP/Mg2+ binding site [chemical binding]; other site
608538003604	Switch I region; other site
608538003605	G2 box; other site
608538003606	G3 box; other site
608538003607	Switch II region; other site
608538003608	G4 box; other site
608538003609	G5 box; other site
608538003610	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
608538003611	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
608538003612	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
608538003613	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
608538003614	active site
608538003615	comF family protein; Region: comF; TIGR00201
608538003616	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538003617	active site
608538003618	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
608538003619	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538003620	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538003621	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538003622	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
608538003623	DHH family; Region: DHH; pfam01368
608538003624	DHHA1 domain; Region: DHHA1; pfam02272
608538003625	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
608538003626	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
608538003627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003628	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
608538003629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003630	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
608538003631	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
608538003632	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
608538003633	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
608538003634	active site
608538003635	dimer interface [polypeptide binding]; other site
608538003636	motif 1; other site
608538003637	motif 2; other site
608538003638	motif 3; other site
608538003639	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
608538003640	anticodon binding site; other site
608538003641	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003642	Ligand Binding Site [chemical binding]; other site
608538003643	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
608538003644	putative acyl-acceptor binding pocket; other site
608538003645	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
608538003646	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
608538003647	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
608538003648	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
608538003649	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
608538003650	trimerization site [polypeptide binding]; other site
608538003651	active site
608538003652	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
608538003653	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
608538003654	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538003655	CPxP  motif; other site
608538003656	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
608538003657	NifU-like domain; Region: NifU; cl00484
608538003658	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
608538003659	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
608538003660	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
608538003661	shikimate binding site; other site
608538003662	NAD(P) binding site [chemical binding]; other site
608538003663	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
608538003664	Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894
608538003665	active site
608538003666	dimer interface [polypeptide binding]; other site
608538003667	GTP-binding protein LepA; Provisional; Region: PRK05433
608538003668	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
608538003669	G1 box; other site
608538003670	putative GEF interaction site [polypeptide binding]; other site
608538003671	GTP/Mg2+ binding site [chemical binding]; other site
608538003672	Switch I region; other site
608538003673	G2 box; other site
608538003674	G3 box; other site
608538003675	Switch II region; other site
608538003676	G4 box; other site
608538003677	G5 box; other site
608538003678	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
608538003679	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
608538003680	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
608538003681	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
608538003682	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
608538003683	ssDNA binding site; other site
608538003684	generic binding surface II; other site
608538003685	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538003686	ATP binding site [chemical binding]; other site
608538003687	putative Mg++ binding site [ion binding]; other site
608538003688	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538003689	nucleotide binding region [chemical binding]; other site
608538003690	ATP-binding site [chemical binding]; other site
608538003691	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
608538003692	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
608538003693	GMP synthase; Reviewed; Region: guaA; PRK00074
608538003694	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
608538003695	AMP/PPi binding site [chemical binding]; other site
608538003696	candidate oxyanion hole; other site
608538003697	catalytic triad [active]
608538003698	potential glutamine specificity residues [chemical binding]; other site
608538003699	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
608538003700	ATP Binding subdomain [chemical binding]; other site
608538003701	Ligand Binding sites [chemical binding]; other site
608538003702	Dimerization subdomain; other site
608538003703	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
608538003704	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538003705	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
608538003706	Walker A/P-loop; other site
608538003707	ATP binding site [chemical binding]; other site
608538003708	Q-loop/lid; other site
608538003709	ABC transporter signature motif; other site
608538003710	Walker B; other site
608538003711	D-loop; other site
608538003712	H-loop/switch region; other site
608538003713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538003714	dimer interface [polypeptide binding]; other site
608538003715	conserved gate region; other site
608538003716	putative PBP binding loops; other site
608538003717	ABC-ATPase subunit interface; other site
608538003718	TOBE domain; Region: TOBE_2; cl01440
608538003719	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
608538003720	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
608538003721	TOBE domain; Region: TOBE_2; cl01440
608538003722	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538003723	non-specific DNA binding site [nucleotide binding]; other site
608538003724	salt bridge; other site
608538003725	sequence-specific DNA binding site [nucleotide binding]; other site
608538003726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
608538003727	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003728	metal-binding site [ion binding]
608538003729	mercuric reductase; Region: MerA; TIGR02053
608538003730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003731	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003732	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538003733	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003734	metal-binding site [ion binding]
608538003735	MerT mercuric transport protein; Region: MerT; cl03578
608538003736	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
608538003737	putative homodimer interface [polypeptide binding]; other site
608538003738	putative homotetramer interface [polypeptide binding]; other site
608538003739	putative allosteric switch controlling residues; other site
608538003740	putative metal binding site [ion binding]; other site
608538003741	putative homodimer-homodimer interface [polypeptide binding]; other site
608538003742	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
608538003743	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
608538003744	GTP binding site; other site
608538003745	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003746	metal-binding site [ion binding]
608538003747	Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112
608538003748	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
608538003749	active site
608538003750	substrate binding site [chemical binding]; other site
608538003751	ATP binding site [chemical binding]; other site
608538003752	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
608538003753	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538003754	minor groove reading motif; other site
608538003755	helix-hairpin-helix signature motif; other site
608538003756	substrate binding pocket [chemical binding]; other site
608538003757	active site
608538003758	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
608538003759	Cytochrome c; Region: Cytochrom_C; cl11414
608538003760	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
608538003761	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
608538003762	Qi binding site; other site
608538003763	intrachain domain interface; other site
608538003764	interchain domain interface [polypeptide binding]; other site
608538003765	heme bH binding site [chemical binding]; other site
608538003766	heme bL binding site [chemical binding]; other site
608538003767	Qo binding site; other site
608538003768	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
608538003769	interchain domain interface [polypeptide binding]; other site
608538003770	intrachain domain interface; other site
608538003771	Qi binding site; other site
608538003772	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
608538003773	Qo binding site; other site
608538003774	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
608538003775	iron-sulfur cluster [ion binding]; other site
608538003776	[2Fe-2S] cluster binding site [ion binding]; other site
608538003777	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
608538003778	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
608538003779	active site
608538003780	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
608538003781	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
608538003782	putative ADP-binding pocket [chemical binding]; other site
608538003783	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
608538003784	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003785	MutS2 family protein; Region: mutS2; TIGR01069
608538003786	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
608538003787	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
608538003788	Walker A/P-loop; other site
608538003789	ATP binding site [chemical binding]; other site
608538003790	Q-loop/lid; other site
608538003791	ABC transporter signature motif; other site
608538003792	Walker B; other site
608538003793	D-loop; other site
608538003794	H-loop/switch region; other site
608538003795	Smr domain; Region: Smr; cl02619
608538003796	potential frameshift: common BLAST hit: gi|288817812|ref|YP_003432159.1| transposase
608538003797	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538003798	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538003799	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
608538003800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538003801	TPR motif; other site
608538003802	TPR repeat; Region: TPR_11; pfam13414
608538003803	binding surface
608538003804	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538003805	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
608538003806	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
608538003807	catalytic residues [active]
608538003808	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538003809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003810	S-adenosylmethionine binding site [chemical binding]; other site
608538003811	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
608538003812	ligand binding site; other site
608538003813	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
608538003814	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538003815	inhibitor-cofactor binding pocket; inhibition site
608538003816	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003817	catalytic residue [active]
608538003818	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003819	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003820	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003821	active site
608538003822	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
608538003823	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538003824	Helix-turn-helix domains; Region: HTH; cl00088
608538003825	Protein of unknown function (DUF434); Region: DUF434; cl04460
608538003826	NosL; Region: NosL; cl01769
608538003827	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
608538003828	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
608538003829	dimerization domain [polypeptide binding]; other site
608538003830	dimer interface [polypeptide binding]; other site
608538003831	catalytic residues [active]
608538003832	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
608538003833	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
608538003834	substrate-cofactor binding pocket; other site
608538003835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003836	catalytic residue [active]
608538003837	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
608538003838	structural tetrad; other site
608538003839	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
608538003840	MoxR-like ATPases [General function prediction only]; Region: COG0714
608538003841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003842	reverse gyrase; Reviewed; Region: PRK09401
608538003843	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538003844	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
608538003845	active site
608538003846	metal binding site [ion binding]; metal-binding site
608538003847	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
608538003848	domain I; other site
608538003849	DNA binding groove [nucleotide binding]
608538003850	phosphate binding site [ion binding]; other site
608538003851	domain II; other site
608538003852	domain III; other site
608538003853	nucleotide binding site [chemical binding]; other site
608538003854	catalytic site [active]
608538003855	domain IV; other site
608538003856	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
608538003857	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
608538003858	TPP-binding site; other site
608538003859	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
608538003860	PYR/PP interface [polypeptide binding]; other site
608538003861	dimer interface [polypeptide binding]; other site
608538003862	TPP binding site [chemical binding]; other site
608538003863	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538003864	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
608538003865	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
608538003866	putative NAD(P) binding site [chemical binding]; other site
608538003867	active site
608538003868	putative substrate binding site [chemical binding]; other site
608538003869	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
608538003870	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
608538003871	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538003872	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538003873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538003874	motif II; other site
608538003875	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538003876	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538003877	DNA primase, catalytic core; Region: dnaG; TIGR01391
608538003878	CHC2 zinc finger; Region: zf-CHC2; cl15369
608538003879	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
608538003880	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
608538003881	active site
608538003882	metal binding site [ion binding]; metal-binding site
608538003883	interdomain interaction site; other site
608538003884	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
608538003885	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
608538003886	active site
608538003887	catalytic residues [active]
608538003888	metal binding site [ion binding]; metal-binding site
608538003889	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
608538003890	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
608538003891	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
608538003892	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
608538003893	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
608538003894	Catalytic dyad [active]
608538003895	UGMP family protein; Validated; Region: PRK09604
608538003896	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
608538003897	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
608538003898	active site
608538003899	Ap6A binding site [chemical binding]; other site
608538003900	nudix motif; other site
608538003901	metal binding site [ion binding]; metal-binding site
608538003902	threonine synthase; Reviewed; Region: PRK06721
608538003903	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
608538003904	homodimer interface [polypeptide binding]; other site
608538003905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003906	catalytic residue [active]
608538003907	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
608538003908	Thymidylate synthase complementing protein; Region: Thy1; cl03630
608538003909	Thymidylate synthase complementing protein; Region: Thy1; cl03630
608538003910	hypothetical protein; Provisional; Region: PRK11820
608538003911	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
608538003912	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
608538003913	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
608538003914	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
608538003915	catalytic residues [active]
608538003916	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
608538003917	ATP synthase A chain; Region: ATP-synt_A; cl00413
608538003918	ATP synthase subunit C; Region: ATP-synt_C; cl00466
608538003919	Haemolytic domain; Region: Haemolytic; cl00506
608538003920	membrane protein insertase; Provisional; Region: PRK01318
608538003921	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
608538003922	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
608538003923	selenium donor protein; Region: selD; TIGR00476
608538003924	dimerization interface [polypeptide binding]; other site
608538003925	putative ATP binding site [chemical binding]; other site
608538003926	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538003927	MoaE interaction surface [polypeptide binding]; other site
608538003928	MoeB interaction surface [polypeptide binding]; other site
608538003929	thiocarboxylated glycine; other site
608538003930	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538003931	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538003932	putative active site [active]
608538003933	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
608538003934	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
608538003935	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
608538003936	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
608538003937	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
608538003938	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
608538003939	pyruvate carboxylase subunit B; Validated; Region: PRK09282
608538003940	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
608538003941	active site
608538003942	catalytic residues [active]
608538003943	metal binding site [ion binding]; metal-binding site
608538003944	homodimer binding site [polypeptide binding]; other site
608538003945	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538003946	carboxyltransferase (CT) interaction site; other site
608538003947	biotinylation site [posttranslational modification]; other site
608538003948	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538003949	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538003950	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538003951	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
608538003952	OsmC-like protein; Region: OsmC; cl00767
608538003953	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
608538003954	Chorismate mutase type II; Region: CM_2; cl00693
608538003955	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
608538003956	Prephenate dehydratase; Region: PDT; pfam00800
608538003957	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
608538003958	putative L-Phe binding site [chemical binding]; other site
608538003959	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
608538003960	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
608538003961	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
608538003962	Mechanosensitive ion channel; Region: MS_channel; pfam00924
608538003963	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538003964	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538003965	putative active site [active]
608538003966	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
608538003967	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
608538003968	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
608538003969	putative ligand binding site [chemical binding]; other site
608538003970	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
608538003971	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
608538003972	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
608538003973	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
608538003974	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
608538003975	Cytochrome c; Region: Cytochrom_C; cl11414
608538003976	XPG domain containing; Region: XPG_I_2; pfam12813
608538003977	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
608538003978	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
608538003979	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
608538003980	P loop; other site
608538003981	GTP binding site [chemical binding]; other site
608538003982	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
608538003983	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
608538003984	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
608538003985	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
608538003986	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
608538003987	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
608538003988	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
608538003989	Ligand Binding Site [chemical binding]; other site
608538003990	pteridine reductase; Provisional; Region: PRK09135
608538003991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538003992	NAD(P) binding site [chemical binding]; other site
608538003993	active site
608538003994	threonine synthase; Validated; Region: PRK07591
608538003995	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
608538003996	homodimer interface [polypeptide binding]; other site
608538003997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003998	catalytic residue [active]
608538003999	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538004000	catalytic residues [active]
608538004001	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
608538004002	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538004003	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004004	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
608538004005	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
608538004006	Domain of unknown function (DUF202); Region: DUF202; cl09954
608538004007	Domain of unknown function (DUF202); Region: DUF202; cl09954
608538004008	adenylosuccinate lyase; Provisional; Region: PRK07492
608538004009	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
608538004010	tetramer interface [polypeptide binding]; other site
608538004011	active site
608538004012	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
608538004013	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538004014	amidophosphoribosyltransferase; Region: purF; TIGR01134
608538004015	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
608538004016	active site
608538004017	tetramer interface [polypeptide binding]; other site
608538004018	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538004019	active site
608538004020	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
608538004021	NeuB family; Region: NeuB; cl00496
608538004022	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
608538004023	dimer interface [polypeptide binding]; other site
608538004024	motif 1; other site
608538004025	active site
608538004026	motif 2; other site
608538004027	motif 3; other site
608538004028	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
608538004029	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538004030	RNA binding site [nucleotide binding]; other site
608538004031	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
608538004032	Oligomerisation domain; Region: Oligomerisation; cl00519
608538004033	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
608538004034	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
608538004035	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538004036	G1 box; other site
608538004037	GTP/Mg2+ binding site [chemical binding]; other site
608538004038	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
608538004039	G2 box; other site
608538004040	Switch I region; other site
608538004041	G3 box; other site
608538004042	Switch II region; other site
608538004043	G4 box; other site
608538004044	G5 box; other site
608538004045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004047	active site
608538004048	phosphorylation site [posttranslational modification]
608538004049	intermolecular recognition site; other site
608538004050	dimerization interface [polypeptide binding]; other site
608538004051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004052	DNA binding site [nucleotide binding]
608538004053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538004054	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
608538004055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538004056	dimer interface [polypeptide binding]; other site
608538004057	phosphorylation site [posttranslational modification]
608538004058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538004059	ATP binding site [chemical binding]; other site
608538004060	Mg2+ binding site [ion binding]; other site
608538004061	G-X-G motif; other site
608538004062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538004063	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
608538004064	metal binding site 2 [ion binding]; metal-binding site
608538004065	putative DNA binding helix; other site
608538004066	metal binding site 1 [ion binding]; metal-binding site
608538004067	dimer interface [polypeptide binding]; other site
608538004068	structural Zn2+ binding site [ion binding]; other site
608538004069	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
608538004070	aromatic arch; other site
608538004071	DCoH dimer interaction site [polypeptide binding]; other site
608538004072	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
608538004073	DCoH tetramer interaction site [polypeptide binding]; other site
608538004074	substrate binding site [chemical binding]; other site
608538004075	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
608538004076	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538004077	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538004078	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
608538004079	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538004080	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
608538004081	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
608538004082	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
608538004083	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
608538004084	RNA/DNA hybrid binding site [nucleotide binding]; other site
608538004085	active site
608538004086	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
608538004087	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
608538004088	Amidase; Region: Amidase; cl11426
608538004089	pyruvate carboxylase subunit B; Validated; Region: PRK09282
608538004090	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
608538004091	active site
608538004092	catalytic residues [active]
608538004093	metal binding site [ion binding]; metal-binding site
608538004094	homodimer binding site [polypeptide binding]; other site
608538004095	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538004096	carboxyltransferase (CT) interaction site; other site
608538004097	biotinylation site [posttranslational modification]; other site
608538004098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004100	active site
608538004101	phosphorylation site [posttranslational modification]
608538004102	intermolecular recognition site; other site
608538004103	dimerization interface [polypeptide binding]; other site
608538004104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004105	DNA binding site [nucleotide binding]
608538004106	Predicted phosphohydrolases [General function prediction only]; Region: COG1408
608538004107	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
608538004108	putative active site [active]
608538004109	putative metal binding site [ion binding]; other site
608538004110	CTP synthetase; Validated; Region: pyrG; PRK05380
608538004111	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
608538004112	Catalytic site [active]
608538004113	active site
608538004114	UTP binding site [chemical binding]; other site
608538004115	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
608538004116	active site
608538004117	putative oxyanion hole; other site
608538004118	catalytic triad [active]
608538004119	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
608538004120	Moco binding site; other site
608538004121	metal coordination site [ion binding]; other site
608538004122	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
608538004123	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538004124	RNA binding surface [nucleotide binding]; other site
608538004125	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
608538004126	active site
608538004127	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538004128	catalytic residues [active]
608538004129	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
608538004130	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
608538004131	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
608538004132	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
608538004133	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
608538004134	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004135	Cytochrome c; Region: Cytochrom_C; cl11414
608538004136	Cytochrome c; Region: Cytochrom_C; cl11414
608538004137	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
608538004138	ATP-dependent DNA ligase; Provisional; Region: PRK01109
608538004139	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
608538004140	active site
608538004141	DNA binding site [nucleotide binding]
608538004142	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_I; cd07969
608538004143	DNA binding site [nucleotide binding]
608538004144	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
608538004145	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
608538004146	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
608538004147	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538004148	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
608538004149	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538004150	DNA binding residues [nucleotide binding]
608538004151	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
608538004152	FMN binding site [chemical binding]; other site
608538004153	dimer interface [polypeptide binding]; other site
608538004154	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538004155	active site
608538004156	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
608538004157	Type III pantothenate kinase; Region: Pan_kinase; cl09130
608538004158	homoserine kinase; Provisional; Region: PRK01212
608538004159	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
608538004160	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
608538004161	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
608538004162	NlpC/P60 family; Region: NLPC_P60; cl11438
608538004163	ApbE family; Region: ApbE; cl00643
608538004164	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
608538004165	Subunit I/III interface [polypeptide binding]; other site
608538004166	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538004167	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
608538004168	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538004169	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
608538004170	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538004171	D-pathway; other site
608538004172	Low-spin heme binding site [chemical binding]; other site
608538004173	Putative water exit pathway; other site
608538004174	Binuclear center (active site) [active]
608538004175	K-pathway; other site
608538004176	Putative proton exit pathway; other site
608538004177	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538004178	Heme NO binding; Region: HNOB; cl15268
608538004179	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
608538004180	octamerization interface [polypeptide binding]; other site
608538004181	diferric-oxygen binding site [ion binding]; other site
608538004182	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
608538004183	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538004184	Low-spin heme binding site [chemical binding]; other site
608538004185	D-pathway; other site
608538004186	Putative water exit pathway; other site
608538004187	Binuclear center (active site) [active]
608538004188	K-pathway; other site
608538004189	Putative proton exit pathway; other site
608538004190	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538004191	Cu(I) binding site [ion binding]; other site
608538004192	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
608538004193	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
608538004194	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
608538004195	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
608538004196	NMT1-like family; Region: NMT1_2; cl15260
608538004197	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
608538004198	30S subunit binding site; other site
608538004199	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
608538004200	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
608538004201	active site
608538004202	substrate binding site [chemical binding]; other site
608538004203	cosubstrate binding site; other site
608538004204	catalytic site [active]
608538004205	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
608538004206	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
608538004207	tetramer interface [polypeptide binding]; other site
608538004208	TPP-binding site [chemical binding]; other site
608538004209	heterodimer interface [polypeptide binding]; other site
608538004210	phosphorylation loop region [posttranslational modification]
608538004211	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
608538004212	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
608538004213	alpha subunit interface [polypeptide binding]; other site
608538004214	TPP binding site [chemical binding]; other site
608538004215	heterodimer interface [polypeptide binding]; other site
608538004216	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538004217	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
608538004218	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
608538004219	E3 interaction surface; other site
608538004220	lipoyl attachment site [posttranslational modification]; other site
608538004221	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
608538004222	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538004223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004224	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538004225	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538004226	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
608538004227	active site
608538004228	dimerization interface [polypeptide binding]; other site
608538004229	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538004230	Ligand Binding Site [chemical binding]; other site
608538004231	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538004232	Ligand Binding Site [chemical binding]; other site
608538004233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004234	binding surface
608538004235	TPR motif; other site
608538004236	Tetratricopeptide repeat; Region: TPR_16; pfam13432
608538004237	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004238	binding surface
608538004239	TPR motif; other site
608538004240	Tetratricopeptide repeat; Region: TPR_16; pfam13432
608538004241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004242	binding surface
608538004243	TPR motif; other site
608538004244	Tetratricopeptide repeat; Region: TPR_15; pfam13429
608538004245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004246	TPR motif; other site
608538004247	binding surface
608538004248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004249	TPR motif; other site
608538004250	binding surface
608538004251	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538004252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004253	active site
608538004254	phosphorylation site [posttranslational modification]
608538004255	intermolecular recognition site; other site
608538004256	dimerization interface [polypeptide binding]; other site
608538004257	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004258	Walker A motif; other site
608538004259	ATP binding site [chemical binding]; other site
608538004260	Walker B motif; other site
608538004261	arginine finger; other site
608538004262	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004264	active site
608538004265	phosphorylation site [posttranslational modification]
608538004266	intermolecular recognition site; other site
608538004267	dimerization interface [polypeptide binding]; other site
608538004268	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004269	DNA binding site [nucleotide binding]
608538004270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538004271	dimer interface [polypeptide binding]; other site
608538004272	phosphorylation site [posttranslational modification]
608538004273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538004274	ATP binding site [chemical binding]; other site
608538004275	Mg2+ binding site [ion binding]; other site
608538004276	G-X-G motif; other site
608538004277	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538004278	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004279	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
608538004280	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004281	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004282	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538004283	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
608538004284	Sulfate transporter family; Region: Sulfate_transp; cl15842
608538004285	Sulfate transporter family; Region: Sulfate_transp; cl15842
608538004286	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
608538004287	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
608538004288	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
608538004289	active site
608538004290	(T/H)XGH motif; other site
608538004291	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
608538004292	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538004293	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538004294	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
608538004295	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
608538004296	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
608538004297	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004298	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004299	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004300	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004301	Cytochrome c; Region: Cytochrom_C; cl11414
608538004302	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
608538004303	active site
608538004304	metal binding site [ion binding]; metal-binding site
608538004305	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
608538004306	Domain of unknown function DUF302; Region: DUF302; cl01364
608538004307	Domain of unknown function DUF302; Region: DUF302; cl01364
608538004308	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
608538004309	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538004310	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
608538004311	nucleotide binding site/active site [active]
608538004312	HIT family signature motif; other site
608538004313	catalytic residue [active]
608538004314	Uncharacterized conserved protein [Function unknown]; Region: COG1565
608538004315	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
608538004316	tartrate dehydrogenase; Provisional; Region: PRK08194
608538004317	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
608538004318	CitB domain protein; Region: CitB; TIGR02484
608538004319	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
608538004320	Cysteine-rich domain; Region: CCG; pfam02754
608538004321	Cysteine-rich domain; Region: CCG; pfam02754
608538004322	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
608538004323	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538004324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004325	homodimer interface [polypeptide binding]; other site
608538004326	catalytic residue [active]
608538004327	Protein of unknown function, DUF399; Region: DUF399; cl01139
608538004328	recombination protein RecR; Region: recR; TIGR00615
608538004329	RecR protein; Region: RecR; pfam02132
608538004330	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
608538004331	putative active site [active]
608538004332	putative metal-binding site [ion binding]; other site
608538004333	tetramer interface [polypeptide binding]; other site
608538004334	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
608538004335	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
608538004336	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538004337	lipoyl attachment site [posttranslational modification]; other site
608538004338	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
608538004339	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
608538004340	tetramer interface [polypeptide binding]; other site
608538004341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004342	catalytic residue [active]
608538004343	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
608538004344	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
608538004345	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
608538004346	pseudaminic acid synthase; Region: PseI; TIGR03586
608538004347	NeuB family; Region: NeuB; cl00496
608538004348	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
608538004349	NeuB binding interface [polypeptide binding]; other site
608538004350	putative substrate binding site [chemical binding]; other site
608538004351	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
608538004352	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
608538004353	NAD(P) binding site [chemical binding]; other site
608538004354	homodimer interface [polypeptide binding]; other site
608538004355	substrate binding site [chemical binding]; other site
608538004356	active site
608538004357	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538004358	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
608538004359	inhibitor-cofactor binding pocket; inhibition site
608538004360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004361	catalytic residue [active]
608538004362	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
608538004363	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538004364	active site
608538004365	catalytic tetrad [active]
608538004366	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
608538004367	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004368	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
608538004369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004370	Walker A motif; other site
608538004371	ATP binding site [chemical binding]; other site
608538004372	Walker B motif; other site
608538004373	arginine finger; other site
608538004374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004375	Walker A motif; other site
608538004376	ATP binding site [chemical binding]; other site
608538004377	Walker B motif; other site
608538004378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
608538004379	GTP-binding protein Der; Reviewed; Region: PRK00093
608538004380	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
608538004381	G1 box; other site
608538004382	GTP/Mg2+ binding site [chemical binding]; other site
608538004383	Switch I region; other site
608538004384	G2 box; other site
608538004385	Switch II region; other site
608538004386	G3 box; other site
608538004387	G4 box; other site
608538004388	G5 box; other site
608538004389	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
608538004390	G1 box; other site
608538004391	GTP/Mg2+ binding site [chemical binding]; other site
608538004392	Switch I region; other site
608538004393	G2 box; other site
608538004394	G3 box; other site
608538004395	Switch II region; other site
608538004396	G4 box; other site
608538004397	G5 box; other site
608538004398	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
608538004399	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
608538004400	Walker A/P-loop; other site
608538004401	ATP binding site [chemical binding]; other site
608538004402	Q-loop/lid; other site
608538004403	ABC transporter signature motif; other site
608538004404	Walker B; other site
608538004405	D-loop; other site
608538004406	H-loop/switch region; other site
608538004407	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
608538004408	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
608538004409	nucleotide binding site/active site [active]
608538004410	HIT family signature motif; other site
608538004411	catalytic residue [active]
608538004412	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538004413	catalytic residues [active]
608538004414	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
608538004415	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538004416	N-terminal plug; other site
608538004417	ligand-binding site [chemical binding]; other site
608538004418	Response regulator receiver domain; Region: Response_reg; pfam00072
608538004419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004420	active site
608538004421	phosphorylation site [posttranslational modification]
608538004422	intermolecular recognition site; other site
608538004423	dimerization interface [polypeptide binding]; other site
608538004424	Predicted membrane-associated trancriptional regulator    [Transcription]; Region: COG2512
608538004425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
608538004426	Histidine kinase; Region: HisKA_2; cl06527
608538004427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
608538004428	NADH dehydrogenase; Region: NADHdh; cl00469
608538004429	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
608538004430	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
608538004431	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
608538004432	TPP-binding site [chemical binding]; other site
608538004433	dimer interface [polypeptide binding]; other site
608538004434	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
608538004435	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538004436	dimer interface [polypeptide binding]; other site
608538004437	PYR/PP interface [polypeptide binding]; other site
608538004438	TPP binding site [chemical binding]; other site
608538004439	substrate binding site [chemical binding]; other site
608538004440	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538004441	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
608538004442	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
608538004443	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
608538004444	protein binding site [polypeptide binding]; other site
608538004445	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
608538004446	Active site serine [active]
608538004447	Predicted kinase [General function prediction only]; Region: COG0645
608538004448	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
608538004449	ATP-binding site [chemical binding]; other site
608538004450	Gluconate-6-phosphate binding site [chemical binding]; other site
608538004451	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
608538004452	catalytic residues [active]
608538004453	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
608538004454	active site
608538004455	catalytic site [active]
608538004456	substrate binding site [chemical binding]; other site
608538004457	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
608538004458	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538004459	ligand binding site [chemical binding]; other site
608538004460	flexible hinge region; other site
608538004461	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
608538004462	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538004463	metal binding triad; other site
608538004464	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
608538004465	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
608538004466	Na binding site [ion binding]; other site
608538004467	Protein of unknown function, DUF485; Region: DUF485; cl01231
608538004468	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
608538004469	thiS-thiF/thiG interaction site; other site
608538004470	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
608538004471	ThiS interaction site; other site
608538004472	putative active site [active]
608538004473	tetramer interface [polypeptide binding]; other site
608538004474	protoporphyrinogen oxidase; Region: PLN02576
608538004475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004476	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
608538004477	active site
608538004478	intersubunit interactions; other site
608538004479	catalytic residue [active]
608538004480	RIP metalloprotease RseP; Region: TIGR00054
608538004481	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
608538004482	active site
608538004483	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
608538004484	protein binding site [polypeptide binding]; other site
608538004485	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
608538004486	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
608538004487	putative substrate binding region [chemical binding]; other site
608538004488	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
608538004489	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538004490	Heme NO binding; Region: HNOB; cl15268
608538004491	Domain of unknown function DUF59; Region: DUF59; cl00941
608538004492	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
608538004493	UDP-glucose-4-epimerase; Region: galE; TIGR01179
608538004494	NAD binding site [chemical binding]; other site
608538004495	homodimer interface [polypeptide binding]; other site
608538004496	active site
608538004497	substrate binding site [chemical binding]; other site
608538004498	Clp protease ATP binding subunit; Region: clpC; CHL00095
608538004499	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004500	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004502	Walker A motif; other site
608538004503	ATP binding site [chemical binding]; other site
608538004504	Walker B motif; other site
608538004505	arginine finger; other site
608538004506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004507	Walker A motif; other site
608538004508	ATP binding site [chemical binding]; other site
608538004509	Walker B motif; other site
608538004510	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
608538004511	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004512	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
608538004513	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538004514	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004515	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004516	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
608538004517	Actin cytoskeleton-regulatory complex protein END3; Region: End3; pfam12761
608538004518	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004519	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
608538004520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004521	active site
608538004522	motif I; other site
608538004523	motif II; other site
608538004524	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
608538004525	Cupin domain; Region: Cupin_2; cl09118
608538004526	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
608538004527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004528	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
608538004529	Cation efflux family; Region: Cation_efflux; cl00316
608538004530	Nitrogen regulatory protein P-II; Region: P-II; cl00412
608538004531	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538004532	glutamine synthetase, type I; Region: GlnA; TIGR00653
608538004533	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
608538004534	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
608538004535	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
608538004536	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
608538004537	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
608538004538	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004539	active site
608538004540	motif I; other site
608538004541	motif II; other site
608538004542	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004543	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
608538004544	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
608538004545	catalytic triad [active]
608538004546	NMT1-like family; Region: NMT1_2; cl15260
608538004547	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
608538004548	ADP-ribose binding site [chemical binding]; other site
608538004549	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
608538004550	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
608538004551	motif 1; other site
608538004552	dimer interface [polypeptide binding]; other site
608538004553	active site
608538004554	motif 3; other site
608538004555	S-adenosylmethionine synthetase; Validated; Region: PRK05250
608538004556	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
608538004557	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
608538004558	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
608538004559	seryl-tRNA synthetase; Provisional; Region: PRK05431
608538004560	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
608538004561	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
608538004562	dimer interface [polypeptide binding]; other site
608538004563	active site
608538004564	motif 1; other site
608538004565	motif 2; other site
608538004566	motif 3; other site
608538004567	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
608538004568	nudix motif; other site
608538004569	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
608538004570	active site residue [active]
608538004571	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538004572	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538004573	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538004574	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
608538004575	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
608538004576	octamerization interface [polypeptide binding]; other site
608538004577	diferric-oxygen binding site [ion binding]; other site
608538004578	NIL domain; Region: NIL; cl09633
608538004579	thiamine-monophosphate kinase; Region: thiL; TIGR01379
608538004580	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
608538004581	ATP binding site [chemical binding]; other site
608538004582	dimerization interface [polypeptide binding]; other site
608538004583	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
608538004584	SmpB-tmRNA interface; other site
608538004585	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
608538004586	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
608538004587	Protein of unknown function DUF116; Region: DUF116; cl00800
608538004588	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
608538004589	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
608538004590	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
608538004591	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538004592	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538004593	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
608538004594	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
608538004595	phenylalanine ammonia-lyase; Region: PLN02457
608538004596	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
608538004597	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
608538004598	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
608538004599	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
608538004600	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
608538004601	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
608538004602	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
608538004603	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
608538004604	putative active site [active]
608538004605	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
608538004606	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
608538004607	dimer interface [polypeptide binding]; other site
608538004608	substrate binding site [chemical binding]; other site
608538004609	metal binding sites [ion binding]; metal-binding site
608538004610	Protein of unknown function (DUF420); Region: DUF420; cl00989
608538004611	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
608538004612	metal binding site 2 [ion binding]; metal-binding site
608538004613	putative DNA binding helix; other site
608538004614	metal binding site 1 [ion binding]; metal-binding site
608538004615	dimer interface [polypeptide binding]; other site
608538004616	structural Zn2+ binding site [ion binding]; other site
608538004617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538004618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538004619	ATP binding site [chemical binding]; other site
608538004620	putative Mg++ binding site [ion binding]; other site
608538004621	Restriction endonuclease [Defense mechanisms]; Region: COG3587
608538004622	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
608538004623	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
608538004624	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
608538004625	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
608538004626	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
608538004627	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
608538004628	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
608538004629	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538004630	ligand binding site [chemical binding]; other site
608538004631	flexible hinge region; other site
608538004632	Helix-turn-helix domains; Region: HTH; cl00088
608538004633	non-specific DNA interactions [nucleotide binding]; other site
608538004634	DNA binding site [nucleotide binding]
608538004635	sequence specific DNA binding site [nucleotide binding]; other site
608538004636	putative cAMP binding site [chemical binding]; other site
608538004637	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
608538004638	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
608538004639	purine monophosphate binding site [chemical binding]; other site
608538004640	dimer interface [polypeptide binding]; other site
608538004641	putative catalytic residues [active]
608538004642	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
608538004643	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
608538004644	Preprotein translocase subunit; Region: YajC; cl00806
608538004645	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
608538004646	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
608538004647	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
608538004648	ScpA/B protein; Region: ScpA_ScpB; cl00598
608538004649	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
608538004650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538004651	S-adenosylmethionine binding site [chemical binding]; other site
608538004652	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
608538004653	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
608538004654	ketol-acid reductoisomerase; Provisional; Region: PRK05479
608538004655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004656	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
608538004657	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538004658	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
608538004659	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
608538004660	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
608538004661	FMN binding site [chemical binding]; other site
608538004662	substrate binding site [chemical binding]; other site
608538004663	putative catalytic residue [active]
608538004664	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
608538004665	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004666	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
608538004667	ABC-2 type transporter; Region: ABC2_membrane; cl11417
608538004668	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
608538004669	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
608538004670	Walker A/P-loop; other site
608538004671	ATP binding site [chemical binding]; other site
608538004672	Q-loop/lid; other site
608538004673	ABC transporter signature motif; other site
608538004674	Walker B; other site
608538004675	D-loop; other site
608538004676	H-loop/switch region; other site
608538004677	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
608538004678	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
608538004679	Protein export membrane protein; Region: SecD_SecF; cl14618
608538004680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
608538004681	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
608538004682	phosphoenolpyruvate synthase; Validated; Region: PRK06464
608538004683	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
608538004684	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
608538004685	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
608538004686	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
608538004687	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
608538004688	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538004689	Secretin and TonB N terminus short domain; Region: STN; cl06624
608538004690	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538004691	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538004692	MatE; Region: MatE; cl10513
608538004693	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004694	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538004696	S-adenosylmethionine binding site [chemical binding]; other site
608538004697	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
608538004698	Ligand binding site; other site
608538004699	Putative Catalytic site; other site
608538004700	DXD motif; other site
608538004701	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004703	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
608538004704	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
608538004705	Uncharacterized conserved protein [Function unknown]; Region: COG1624
608538004706	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
608538004707	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
608538004708	dihydropteroate synthase; Region: DHPS; TIGR01496
608538004709	substrate binding pocket [chemical binding]; other site
608538004710	dimer interface [polypeptide binding]; other site
608538004711	inhibitor binding site; inhibition site
608538004712	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538004713	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
608538004714	putative active site [active]
608538004715	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
608538004716	thymidylate kinase; Validated; Region: tmk; PRK00698
608538004717	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
608538004718	TMP-binding site; other site
608538004719	ATP-binding site [chemical binding]; other site
608538004720	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
608538004721	catalytic triad [active]
608538004722	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
608538004723	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
608538004724	dimer interface [polypeptide binding]; other site
608538004725	active site
608538004726	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
608538004727	dimer interface [polypeptide binding]; other site
608538004728	active site
608538004729	Integral membrane protein TerC family; Region: TerC; cl10468
608538004730	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
608538004731	Gram-negative bacterial tonB protein; Region: TonB; cl10048
608538004732	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
608538004733	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
608538004734	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
608538004735	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
608538004736	putative dimer interface [polypeptide binding]; other site
608538004737	[2Fe-2S] cluster binding site [ion binding]; other site
608538004738	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
608538004739	putative dimer interface [polypeptide binding]; other site
608538004740	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
608538004741	SLBB domain; Region: SLBB; pfam10531
608538004742	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
608538004743	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
608538004744	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538004745	catalytic loop [active]
608538004746	iron binding site [ion binding]; other site
608538004747	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
608538004748	4Fe-4S binding domain; Region: Fer4; cl02805
608538004749	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
608538004750	[4Fe-4S] binding site [ion binding]; other site
608538004751	molybdopterin cofactor binding site; other site
608538004752	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
608538004753	molybdopterin cofactor binding site; other site
608538004754	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
608538004755	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
608538004756	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
608538004757	23S rRNA binding site [nucleotide binding]; other site
608538004758	L21 binding site [polypeptide binding]; other site
608538004759	L13 binding site [polypeptide binding]; other site
608538004760	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
608538004761	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
608538004762	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
608538004763	dimer interface [polypeptide binding]; other site
608538004764	motif 1; other site
608538004765	active site
608538004766	motif 2; other site
608538004767	motif 3; other site
608538004768	sensory histidine kinase AtoS; Provisional; Region: PRK11360
608538004769	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
608538004770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
608538004771	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004773	active site
608538004774	phosphorylation site [posttranslational modification]
608538004775	intermolecular recognition site; other site
608538004776	dimerization interface [polypeptide binding]; other site
608538004777	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004778	DNA binding site [nucleotide binding]
608538004779	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538004780	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538004781	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004782	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004783	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538004784	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
608538004785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538004786	FeS/SAM binding site; other site
608538004787	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
608538004788	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
608538004789	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
608538004790	Protein of unknown function (DUF989); Region: DUF989; pfam06181
608538004791	Protein of unknown function (DUF461); Region: DUF461; cl01071
608538004792	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
608538004793	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
608538004794	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
608538004795	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
608538004796	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538004797	metal-binding site [ion binding]
608538004798	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538004799	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538004800	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
608538004801	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
608538004802	substrate binding site [chemical binding]; other site
608538004803	active site
608538004804	catalytic residues [active]
608538004805	heterodimer interface [polypeptide binding]; other site
608538004806	OsmC-like protein; Region: OsmC; cl00767
608538004807	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
608538004808	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538004809	carboxyltransferase (CT) interaction site; other site
608538004810	biotinylation site [posttranslational modification]; other site
608538004811	elongation factor P; Validated; Region: PRK00529
608538004812	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
608538004813	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
608538004814	RNA binding site [nucleotide binding]; other site
608538004815	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
608538004816	RNA binding site [nucleotide binding]; other site
608538004817	Uncharacterized conserved protein [Function unknown]; Region: COG1912
608538004818	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
608538004819	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
608538004820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538004821	dimer interface [polypeptide binding]; other site
608538004822	conserved gate region; other site
608538004823	putative PBP binding loops; other site
608538004824	ABC-ATPase subunit interface; other site
608538004825	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
608538004826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538004827	dimer interface [polypeptide binding]; other site
608538004828	conserved gate region; other site
608538004829	ABC-ATPase subunit interface; other site
608538004830	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
608538004831	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
608538004832	Walker A/P-loop; other site
608538004833	ATP binding site [chemical binding]; other site
608538004834	Q-loop/lid; other site
608538004835	ABC transporter signature motif; other site
608538004836	Walker B; other site
608538004837	D-loop; other site
608538004838	H-loop/switch region; other site
608538004839	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538004840	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
608538004841	Heme-binding domain of bacterial ethylbenzene dehydrogenase; Region: DOMON_EBDH; cd09623
608538004842	heme binding site [chemical binding]; other site
608538004843	beta subunit binding site [polypeptide binding]; other site
608538004844	DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478
608538004845	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
608538004846	DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479
608538004847	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538004848	molybdopterin cofactor binding site; other site
608538004849	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538004850	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
608538004851	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538004852	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
608538004853	Walker A/P-loop; other site
608538004854	ATP binding site [chemical binding]; other site
608538004855	Q-loop/lid; other site
608538004856	ABC transporter signature motif; other site
608538004857	Walker B; other site
608538004858	D-loop; other site
608538004859	H-loop/switch region; other site
608538004860	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
608538004861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538004862	FtsX-like permease family; Region: FtsX; cl15850
608538004863	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538004864	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004865	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004866	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538004867	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538004868	putative active site [active]
608538004869	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
608538004870	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
608538004871	glutaminase active site [active]
608538004872	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
608538004873	dimer interface [polypeptide binding]; other site
608538004874	active site
608538004875	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
608538004876	dimer interface [polypeptide binding]; other site
608538004877	active site
608538004878	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
608538004879	Protein export membrane protein; Region: SecD_SecF; cl14618
608538004880	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538004881	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004882	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
608538004883	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538004884	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538004885	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538004886	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
608538004887	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538004888	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538004889	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
608538004890	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
608538004891	hinge; other site
608538004892	active site
608538004893	Copper resistance protein D; Region: CopD; cl00563
608538004894	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
608538004895	Flavoprotein; Region: Flavoprotein; cl08021
608538004896	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
608538004897	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
608538004898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004899	active site
608538004900	motif I; other site
608538004901	motif II; other site
608538004902	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
608538004903	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538004904	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
608538004905	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538004906	FeS/SAM binding site; other site
608538004907	ATP cone domain; Region: ATP-cone; pfam03477
608538004908	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
608538004909	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869
608538004910	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
608538004911	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538004912	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538004913	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
608538004914	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
608538004915	putative active site [active]
608538004916	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
608538004917	putative active site [active]
608538004918	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
608538004919	The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763
608538004920	putative [Fe4-S4] binding site [ion binding]; other site
608538004921	putative molybdopterin cofactor binding site [chemical binding]; other site
608538004922	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
608538004923	putative molybdopterin cofactor binding site; other site
608538004924	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
608538004925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004926	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538004927	IHF - DNA interface [nucleotide binding]; other site
608538004928	IHF dimer interface [polypeptide binding]; other site
608538004929	OstA-like protein; Region: OstA; cl00844
608538004930	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
608538004931	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
608538004932	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
608538004933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004934	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
608538004935	homotrimer interaction site [polypeptide binding]; other site
608538004936	zinc binding site [ion binding]; other site
608538004937	CDP-binding sites; other site
608538004938	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
608538004939	active site
608538004940	nucleophile elbow; other site
608538004941	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
608538004942	MatE; Region: MatE; cl10513
608538004943	MatE; Region: MatE; cl10513
608538004944	FMN-binding domain; Region: FMN_bind; cl01081
608538004945	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
608538004946	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538004947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538004948	S-adenosylmethionine binding site [chemical binding]; other site
608538004949	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
608538004950	Helix-turn-helix domains; Region: HTH; cl00088
608538004951	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
608538004952	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538004953	ligand binding site [chemical binding]; other site
608538004954	flexible hinge region; other site
608538004955	Helix-turn-helix domains; Region: HTH; cl00088
608538004956	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
608538004957	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
608538004958	mce related protein; Region: MCE; pfam02470
608538004959	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
608538004960	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549
608538004961	putative active site [active]
608538004962	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
608538004963	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
608538004964	ATP binding site [chemical binding]; other site
608538004965	active site
608538004966	substrate binding site [chemical binding]; other site
608538004967	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
608538004968	Probable transposase; Region: OrfB_IS605; pfam01385
608538004969	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538004970	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538004971	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
608538004972	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
608538004973	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
608538004974	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
608538004975	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538004976	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
608538004977	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
608538004978	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
608538004979	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
608538004980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538004981	dimerization interface [polypeptide binding]; other site
608538004982	putative DNA binding site [nucleotide binding]; other site
608538004983	putative Zn2+ binding site [ion binding]; other site
608538004984	Low molecular weight phosphatase family; Region: LMWPc; cd00115
608538004985	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
608538004986	active site
608538004987	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538004988	Predicted permeases [General function prediction only]; Region: COG0701
608538004989	Predicted permease; Region: DUF318; pfam03773
608538004990	arsenical pump membrane protein; Provisional; Region: PRK15445
608538004991	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
608538004992	transmembrane helices; other site
608538004993	DsrE/DsrF-like family; Region: DrsE; cl00672
608538004994	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
608538004995	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538004996	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538004997	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
608538004998	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538004999	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
608538005000	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
608538005001	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
608538005002	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
608538005003	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
608538005004	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
608538005005	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
608538005006	4Fe-4S binding domain; Region: Fer4; cl02805
608538005007	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
608538005008	oligomerisation interface [polypeptide binding]; other site
608538005009	mobile loop; other site
608538005010	roof hairpin; other site
608538005011	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
608538005012	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
608538005013	ring oligomerisation interface [polypeptide binding]; other site
608538005014	ATP/Mg binding site [chemical binding]; other site
608538005015	stacking interactions; other site
608538005016	hinge regions; other site
608538005017	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
608538005018	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
608538005019	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
608538005020	catalytic residue [active]
608538005021	putative FPP diphosphate  binding site; other site
608538005022	putative FPP binding hydrophobic cleft; other site
608538005023	dimer interface [polypeptide binding]; other site
608538005024	putative IPP diphosphate binding site; other site
608538005025	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
608538005026	Tetratricopeptide repeat; Region: TPR_6; pfam13174
608538005027	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
608538005028	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
608538005029	Cl- selectivity filter; other site
608538005030	Cl- binding residues [ion binding]; other site
608538005031	pore gating glutamate residue; other site
608538005032	dimer interface [polypeptide binding]; other site
608538005033	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
608538005034	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
608538005035	FAD binding domain; Region: FAD_binding_4; pfam01565
608538005036	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
608538005037	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
608538005038	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
608538005039	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538005040	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
608538005041	cell division protein FtsA; Region: ftsA; TIGR01174
608538005042	Cell division protein FtsA; Region: FtsA; cl11496
608538005043	Cell division protein FtsA; Region: FtsA; cl11496
608538005044	cell division protein FtsZ; Validated; Region: PRK09330
608538005045	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
608538005046	nucleotide binding site [chemical binding]; other site
608538005047	SulA interaction site; other site
608538005048	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
608538005049	FixH; Region: FixH; cl01254
608538005050	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
608538005051	DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; Region: DUF619-like; cl14605
608538005052	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
608538005053	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
608538005054	NosL; Region: NosL; cl01769
608538005055	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
608538005056	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538005057	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
608538005058	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538005059	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538005060	HupF/HypC family; Region: HupF_HypC; cl00394
608538005061	Hydrogenase formation hypA family; Region: HypD; cl12072
608538005062	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
608538005063	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
608538005064	putative active site [active]
608538005065	putative substrate binding site [chemical binding]; other site
608538005066	putative cosubstrate binding site; other site
608538005067	catalytic site [active]
608538005068	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
608538005069	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
608538005070	substrate binding site [chemical binding]; other site
608538005071	oxyanion hole (OAH) forming residues; other site
608538005072	trimer interface [polypeptide binding]; other site
608538005073	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538005074	Helix-turn-helix domains; Region: HTH; cl00088
608538005075	Dienelactone hydrolase family; Region: DLH; pfam01738
608538005076	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
608538005077	carbon starvation protein A; Provisional; Region: PRK15015
608538005078	Carbon starvation protein CstA; Region: CstA; pfam02554
608538005079	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
608538005080	ATP phosphoribosyltransferase; Region: HisG; cl15266
608538005081	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
608538005082	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538005083	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
608538005084	PLD-like domain; Region: PLDc_2; pfam13091
608538005085	putative active site [active]
608538005086	catalytic site [active]
608538005087	CAAX protease self-immunity; Region: Abi; cl00558
608538005088	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
608538005089	Cell division protein FtsA; Region: FtsA; cl11496
608538005090	type II secretion system protein E; Region: type_II_gspE; TIGR02533
608538005091	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538005092	Walker A motif; other site
608538005093	ATP binding site [chemical binding]; other site
608538005094	Walker B motif; other site
608538005095	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
608538005096	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
608538005097	dimerization interface [polypeptide binding]; other site
608538005098	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538005099	G1 box; other site
608538005100	GTP/Mg2+ binding site [chemical binding]; other site
608538005101	G2 box; other site
608538005102	Switch I region; other site
608538005103	G3 box; other site
608538005104	Switch II region; other site
608538005105	G4 box; other site
608538005106	G5 box; other site
608538005107	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
608538005108	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
608538005109	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
608538005110	dimer interface [polypeptide binding]; other site
608538005111	active site
608538005112	glycine-pyridoxal phosphate binding site [chemical binding]; other site
608538005113	folate binding site [chemical binding]; other site
608538005114	argininosuccinate lyase; Provisional; Region: PRK00855
608538005115	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
608538005116	active sites [active]
608538005117	tetramer interface [polypeptide binding]; other site
608538005118	Peptidase family M54; Region: Peptidase_M54; cl00835
608538005119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538005120	putative substrate translocation pore; other site
608538005121	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
608538005122	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
608538005123	putative active site pocket [active]
608538005124	4-fold oligomerization interface [polypeptide binding]; other site
608538005125	metal binding residues [ion binding]; metal-binding site
608538005126	3-fold/trimer interface [polypeptide binding]; other site
608538005127	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
608538005128	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
608538005129	transcription termination factor Rho; Provisional; Region: rho; PRK09376
608538005130	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
608538005131	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
608538005132	RNA binding site [nucleotide binding]; other site
608538005133	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
608538005134	multimer interface [polypeptide binding]; other site
608538005135	Walker A motif; other site
608538005136	ATP binding site [chemical binding]; other site
608538005137	Walker B motif; other site
608538005138	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
608538005139	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
608538005140	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
608538005141	GTP/Mg2+ binding site [chemical binding]; other site
608538005142	trmE is a tRNA modification GTPase; Region: trmE; cd04164
608538005143	G1 box; other site
608538005144	G1 box; other site
608538005145	GTP/Mg2+ binding site [chemical binding]; other site
608538005146	Switch I region; other site
608538005147	Switch I region; other site
608538005148	G2 box; other site
608538005149	G2 box; other site
608538005150	Switch II region; other site
608538005151	G3 box; other site
608538005152	G3 box; other site
608538005153	Switch II region; other site
608538005154	G4 box; other site
608538005155	G5 box; other site
608538005156	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
608538005157	aminotransferase; Validated; Region: PRK08175
608538005158	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538005159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538005160	homodimer interface [polypeptide binding]; other site
608538005161	catalytic residue [active]
608538005162	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
608538005163	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
608538005164	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
608538005165	active site
608538005166	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
608538005167	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
608538005168	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
608538005169	Ligand binding site; other site
608538005170	oligomer interface; other site
608538005171	peroxiredoxin; Region: AhpC; TIGR03137
608538005172	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
608538005173	dimer interface [polypeptide binding]; other site
608538005174	decamer (pentamer of dimers) interface [polypeptide binding]; other site
608538005175	catalytic triad [active]
608538005176	peroxidatic and resolving cysteines [active]
608538005177	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538005178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538005179	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
608538005180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538005181	gamma-glutamyl kinase; Provisional; Region: PRK05429
608538005182	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
608538005183	nucleotide binding site [chemical binding]; other site
608538005184	homotetrameric interface [polypeptide binding]; other site
608538005185	putative phosphate binding site [ion binding]; other site
608538005186	putative allosteric binding site; other site
608538005187	PUA domain; Region: PUA; cl00607
608538005188	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
608538005189	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
608538005190	putative NAD(P) binding site [chemical binding]; other site
608538005191	structural Zn binding site [ion binding]; other site
608538005192	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
608538005193	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
608538005194	motif 1; other site
608538005195	active site
608538005196	motif 2; other site
608538005197	motif 3; other site
608538005198	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
608538005199	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
608538005200	peptide chain release factor 1; Validated; Region: prfA; PRK00591
608538005201	RF-1 domain; Region: RF-1; cl02875
608538005202	RF-1 domain; Region: RF-1; cl02875
608538005203	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
608538005204	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
608538005205	RNA binding site [nucleotide binding]; other site
608538005206	active site
608538005207	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
608538005208	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
608538005209	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538005210	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
608538005211	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538005212	DNA binding residues [nucleotide binding]
608538005213	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
608538005214	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
608538005215	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538005216	protein binding site [polypeptide binding]; other site
608538005217	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538005218	protein binding site [polypeptide binding]; other site
608538005219	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
608538005220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538005221	S-adenosylmethionine binding site [chemical binding]; other site
608538005222	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
608538005223	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
608538005224	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
608538005225	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005226	FeS/SAM binding site; other site
608538005227	Sulfatase; Region: Sulfatase; cl10460
608538005228	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
608538005229	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
608538005230	4Fe-4S binding domain; Region: Fer4; cl02805
608538005231	Probable transposase; Region: OrfB_IS605; pfam01385
608538005232	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538005233	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538005234	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
608538005235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538005236	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
608538005237	putative L-serine binding site [chemical binding]; other site
608538005238	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
608538005239	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538005240	catalytic residue [active]
608538005241	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
608538005242	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
608538005243	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
608538005244	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
608538005245	generic binding surface I; other site
608538005246	generic binding surface II; other site
608538005247	FUN14 family; Region: FUN14; cl01015
608538005248	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
608538005249	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005250	FeS/SAM binding site; other site
608538005251	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
608538005252	active site
608538005253	dimerization interface [polypeptide binding]; other site
608538005254	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
608538005255	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
608538005256	phosphate binding site [ion binding]; other site
608538005257	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538005258	lipoyl attachment site [posttranslational modification]; other site
608538005259	DsrE/DsrF-like family; Region: DrsE; cl00672
608538005260	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538005261	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538005262	lipoyl attachment site [posttranslational modification]; other site
608538005263	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005264	Cysteine-rich domain; Region: CCG; pfam02754
608538005265	Cysteine-rich domain; Region: CCG; pfam02754
608538005266	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
608538005267	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538005268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538005269	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
608538005270	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005271	Cysteine-rich domain; Region: CCG; pfam02754
608538005272	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005273	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
608538005274	DsrE/DsrF-like family; Region: DrsE; cl00672
608538005275	DsrE/DsrF-like family; Region: DrsE; cl00672
608538005276	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538005277	CPxP  motif; other site
608538005278	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
608538005279	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
608538005280	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538005281	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
608538005282	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538005283	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
608538005284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538005285	CoA-ligase; Region: Ligase_CoA; cl02894
608538005286	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
608538005287	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538005288	CoA-ligase; Region: Ligase_CoA; cl02894
608538005289	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
608538005290	active site
608538005291	catalytic site [active]
608538005292	substrate binding site [chemical binding]; other site
608538005293	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
608538005294	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
608538005295	HSP70 interaction site [polypeptide binding]; other site
608538005296	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
608538005297	substrate binding site [polypeptide binding]; other site
608538005298	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
608538005299	Zn binding sites [ion binding]; other site
608538005300	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
608538005301	dimer interface [polypeptide binding]; other site
608538005302	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
608538005303	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
608538005304	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
608538005305	active site
608538005306	HIGH motif; other site
608538005307	KMSK motif region; other site
608538005308	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
608538005309	tRNA binding surface [nucleotide binding]; other site
608538005310	anticodon binding site; other site
608538005311	Sporulation related domain; Region: SPOR; cl10051
608538005312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538005313	binding surface
608538005314	TPR motif; other site
608538005315	TPR repeat; Region: TPR_11; pfam13414
608538005316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538005317	TPR motif; other site
608538005318	binding surface
608538005319	Sporulation related domain; Region: SPOR; cl10051
608538005320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538005321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
608538005322	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
608538005323	Protein of unknown function DUF82; Region: DUF82; pfam01927
608538005324	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
608538005325	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
608538005326	substrate binding site [chemical binding]; other site
608538005327	ligand binding site [chemical binding]; other site
608538005328	FtsH Extracellular; Region: FtsH_ext; pfam06480
608538005329	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
608538005330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538005331	Walker A motif; other site
608538005332	ATP binding site [chemical binding]; other site
608538005333	Walker B motif; other site
608538005334	arginine finger; other site
608538005335	Peptidase family M41; Region: Peptidase_M41; pfam01434
608538005336	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
608538005337	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
608538005338	Ligand Binding Site [chemical binding]; other site
608538005339	SapC; Region: SapC; pfam07277
608538005340	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
608538005341	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538005342	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
608538005343	inhibitor-cofactor binding pocket; inhibition site
608538005344	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538005345	catalytic residue [active]
608538005346	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
608538005347	molybdopterin cofactor binding site; other site
608538005348	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
608538005349	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
608538005350	molybdopterin cofactor binding site; other site
608538005351	Competence-damaged protein; Region: CinA; cl00666
608538005352	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
608538005353	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
608538005354	active site
608538005355	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
608538005356	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
608538005357	Substrate binding site; other site
608538005358	Mg++ binding site; other site
608538005359	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
608538005360	active site
608538005361	substrate binding site [chemical binding]; other site
608538005362	CoA binding site [chemical binding]; other site
608538005363	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
608538005364	Ribosome-binding factor A; Region: RBFA; cl00542
608538005365	Superfamily II helicase [General function prediction only]; Region: COG1204
608538005366	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538005367	ATP binding site [chemical binding]; other site
608538005368	putative Mg++ binding site [ion binding]; other site
608538005369	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538005370	nucleotide binding region [chemical binding]; other site
608538005371	ATP-binding site [chemical binding]; other site
608538005372	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
608538005373	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
608538005374	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538005375	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538005376	ATP-grasp domain; Region: ATP-grasp_4; cl03087
608538005377	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365