-- dump date   	20120504_150645
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
575540000001	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540000002	active site
575540000003	ATP binding site [chemical binding]; other site
575540000004	substrate binding site [chemical binding]; other site
575540000005	activation loop (A-loop); other site
575540000006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540000007	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
575540000008	active site
575540000009	substrate-binding site [chemical binding]; other site
575540000010	metal-binding site [ion binding]
575540000011	ATP binding site [chemical binding]; other site
575540000012	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000013	active site
575540000014	ATP binding site [chemical binding]; other site
575540000015	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540000016	substrate binding site [chemical binding]; other site
575540000017	activation loop (A-loop); other site
575540000018	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
575540000019	Aspartase; Region: Aspartase; cd01357
575540000020	active sites [active]
575540000021	tetramer interface [polypeptide binding]; other site
575540000022	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
575540000023	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
575540000024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000025	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540000026	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
575540000027	active site
575540000028	putative lithium-binding site [ion binding]; other site
575540000029	substrate binding site [chemical binding]; other site
575540000030	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
575540000031	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
575540000032	putative ADP-binding pocket [chemical binding]; other site
575540000033	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
575540000034	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
575540000035	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
575540000036	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540000037	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
575540000038	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
575540000039	TPR repeat; Region: TPR_11; pfam13414
575540000040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000041	binding surface
575540000042	TPR motif; other site
575540000043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540000044	binding surface
575540000045	TPR motif; other site
575540000046	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
575540000047	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540000048	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
575540000049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000050	NAD(P) binding site [chemical binding]; other site
575540000051	active site
575540000052	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
575540000053	Replication initiator protein A; Region: RPA; cl02339
575540000054	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540000055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000056	binding surface
575540000057	TPR motif; other site
575540000058	Global regulator protein family; Region: CsrA; cl00670
575540000059	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
575540000060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
575540000061	P-loop; other site
575540000062	Magnesium ion binding site [ion binding]; other site
575540000063	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
575540000064	Magnesium ion binding site [ion binding]; other site
575540000065	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000066	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
575540000067	NAD(P) binding site [chemical binding]; other site
575540000068	active site
575540000069	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
575540000070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540000071	Walker A motif; other site
575540000072	ATP binding site [chemical binding]; other site
575540000073	Walker B motif; other site
575540000074	arginine finger; other site
575540000075	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
575540000076	DnaA box-binding interface [nucleotide binding]; other site
575540000077	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
575540000078	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
575540000079	putative active site [active]
575540000080	catalytic site [active]
575540000081	putative metal binding site [ion binding]; other site
575540000082	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540000083	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
575540000084	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
575540000085	nudix motif; other site
575540000086	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
575540000087	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
575540000088	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540000089	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
575540000090	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
575540000091	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540000092	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
575540000093	IMP binding site; other site
575540000094	dimer interface [polypeptide binding]; other site
575540000095	partial ornithine binding site; other site
575540000096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540000097	dimerization interface [polypeptide binding]; other site
575540000098	putative DNA binding site [nucleotide binding]; other site
575540000099	putative Zn2+ binding site [ion binding]; other site
575540000100	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
575540000101	SdpI/YhfL protein family; Region: SdpI; pfam13630
575540000102	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
575540000103	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
575540000104	active site
575540000105	substrate binding site [chemical binding]; other site
575540000106	metal binding site [ion binding]; metal-binding site
575540000107	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
575540000108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000109	Survival protein SurE; Region: SurE; cl00448
575540000110	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540000111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540000112	active site
575540000113	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540000114	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540000115	Plant ATP synthase F0; Region: YMF19; cl07975
575540000116	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
575540000117	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540000118	Global regulator protein family; Region: CsrA; cl00670
575540000119	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
575540000120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540000121	active site
575540000122	phosphorylation site [posttranslational modification]
575540000123	intermolecular recognition site; other site
575540000124	dimerization interface [polypeptide binding]; other site
575540000125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
575540000126	DNA binding site [nucleotide binding]
575540000127	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
575540000128	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
575540000129	Walker A/P-loop; other site
575540000130	ATP binding site [chemical binding]; other site
575540000131	Q-loop/lid; other site
575540000132	ABC transporter signature motif; other site
575540000133	Walker B; other site
575540000134	D-loop; other site
575540000135	H-loop/switch region; other site
575540000136	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
575540000137	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540000138	active site
575540000139	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540000140	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
575540000141	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540000142	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540000143	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
575540000144	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
575540000145	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540000146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540000147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540000148	DNA binding residues [nucleotide binding]
575540000149	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
575540000150	catalytic triad [active]
575540000151	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540000152	metal ion-dependent adhesion site (MIDAS); other site
575540000153	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
575540000154	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
575540000155	HflX GTPase family; Region: HflX; cd01878
575540000156	G1 box; other site
575540000157	GTP/Mg2+ binding site [chemical binding]; other site
575540000158	Switch I region; other site
575540000159	G2 box; other site
575540000160	G3 box; other site
575540000161	Switch II region; other site
575540000162	G4 box; other site
575540000163	G5 box; other site
575540000164	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
575540000165	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
575540000166	RNA binding site [nucleotide binding]; other site
575540000167	active site
575540000168	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
575540000169	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
575540000170	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
575540000171	Cytochrome c; Region: Cytochrom_C; cl11414
575540000172	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540000173	structural tetrad; other site
575540000174	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540000175	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540000176	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540000177	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
575540000178	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
575540000179	TPP-binding site [chemical binding]; other site
575540000180	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
575540000181	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
575540000182	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
575540000183	E3 interaction surface; other site
575540000184	lipoyl attachment site [posttranslational modification]; other site
575540000185	e3 binding domain; Region: E3_binding; pfam02817
575540000186	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
575540000187	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
575540000188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540000190	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
575540000191	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
575540000192	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
575540000193	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
575540000194	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540000195	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
575540000196	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
575540000197	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
575540000198	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
575540000199	B3/4 domain; Region: B3_4; cl11458
575540000200	MatE; Region: MatE; cl10513
575540000201	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
575540000202	ligand binding site [chemical binding]; other site
575540000203	flexible hinge region; other site
575540000204	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
575540000205	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
575540000206	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
575540000207	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540000208	active site
575540000209	metal binding site [ion binding]; metal-binding site
575540000210	YacP-like NYN domain; Region: NYN_YacP; cl01491
575540000211	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
575540000212	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
575540000213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000214	glutamine synthetase, type I; Region: GlnA; TIGR00653
575540000215	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
575540000216	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
575540000217	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540000218	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540000219	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000220	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
575540000221	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
575540000222	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000223	active site
575540000224	ATP binding site [chemical binding]; other site
575540000225	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000226	substrate binding site [chemical binding]; other site
575540000227	activation loop (A-loop); other site
575540000228	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540000229	structural tetrad; other site
575540000230	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540000231	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
575540000232	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540000233	DNA binding residues [nucleotide binding]
575540000234	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
575540000235	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
575540000236	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
575540000237	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
575540000238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540000240	binding surface
575540000241	TPR motif; other site
575540000242	TPR repeat; Region: TPR_11; pfam13414
575540000243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000244	binding surface
575540000245	TPR motif; other site
575540000246	TPR repeat; Region: TPR_11; pfam13414
575540000247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540000248	Hsp70 protein; Region: HSP70; pfam00012
575540000249	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
575540000250	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
575540000251	CAAX protease self-immunity; Region: Abi; cl00558
575540000252	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540000253	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
575540000254	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
575540000255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000256	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540000257	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540000258	dimerization interface [polypeptide binding]; other site
575540000259	putative DNA binding site [nucleotide binding]; other site
575540000260	putative Zn2+ binding site [ion binding]; other site
575540000261	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540000262	dimerization interface [polypeptide binding]; other site
575540000263	putative DNA binding site [nucleotide binding]; other site
575540000264	putative Zn2+ binding site [ion binding]; other site
575540000265	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540000266	Helix-turn-helix domains; Region: HTH; cl00088
575540000267	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
575540000268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540000269	Walker A motif; other site
575540000270	ATP binding site [chemical binding]; other site
575540000271	Walker B motif; other site
575540000272	arginine finger; other site
575540000273	Peptidase family M41; Region: Peptidase_M41; pfam01434
575540000274	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
575540000275	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
575540000276	substrate binding site [chemical binding]; other site
575540000277	ATP binding site [chemical binding]; other site
575540000278	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
575540000279	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540000280	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
575540000281	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
575540000282	active site
575540000283	substrate binding site [chemical binding]; other site
575540000284	metal binding site [ion binding]; metal-binding site
575540000285	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
575540000286	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
575540000287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000288	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540000289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000290	NAD(P) binding site [chemical binding]; other site
575540000291	active site
575540000292	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
575540000293	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000294	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000295	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540000296	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
575540000297	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
575540000298	catalytic residues [active]
575540000299	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
575540000300	active site
575540000301	zinc binding site [ion binding]; other site
575540000302	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540000303	phosphopeptide binding site; other site
575540000304	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
575540000305	metal binding site [ion binding]; metal-binding site
575540000306	active site
575540000307	I-site; other site
575540000308	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540000309	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540000310	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
575540000311	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
575540000312	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
575540000313	homodimer interface [polypeptide binding]; other site
575540000314	NADP binding site [chemical binding]; other site
575540000315	substrate binding site [chemical binding]; other site
575540000316	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540000317	anti sigma factor interaction site; other site
575540000318	regulatory phosphorylation site [posttranslational modification]; other site
575540000319	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
575540000320	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
575540000321	active site
575540000322	catalytic residues [active]
575540000323	metal binding site [ion binding]; metal-binding site
575540000324	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
575540000325	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
575540000326	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540000327	active site
575540000328	HIGH motif; other site
575540000329	nucleotide binding site [chemical binding]; other site
575540000330	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
575540000331	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
575540000332	active site
575540000333	KMSKS motif; other site
575540000334	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
575540000335	tRNA binding surface [nucleotide binding]; other site
575540000336	anticodon binding site; other site
575540000337	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
575540000338	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
575540000339	dimer interface [polypeptide binding]; other site
575540000340	ADP-ribose binding site [chemical binding]; other site
575540000341	active site
575540000342	nudix motif; other site
575540000343	metal binding site [ion binding]; metal-binding site
575540000344	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000345	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000346	substrate binding site [chemical binding]; other site
575540000347	activation loop (A-loop); other site
575540000348	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540000349	structural tetrad; other site
575540000350	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540000351	structural tetrad; other site
575540000352	FOG: WD40 repeat [General function prediction only]; Region: COG2319
575540000353	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
575540000354	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540000355	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540000356	DNA binding residues [nucleotide binding]
575540000357	Cell differentiation family, Rcd1-like; Region: Rcd1; cl02160
575540000358	S-adenosylmethionine synthetase; Validated; Region: PRK05250
575540000359	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
575540000360	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
575540000361	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
575540000362	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
575540000363	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
575540000364	Sulfatase; Region: Sulfatase; cl10460
575540000365	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540000366	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
575540000367	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
575540000368	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
575540000369	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
575540000370	RPB11 interaction site [polypeptide binding]; other site
575540000371	RPB12 interaction site [polypeptide binding]; other site
575540000372	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
575540000373	RPB3 interaction site [polypeptide binding]; other site
575540000374	RPB1 interaction site [polypeptide binding]; other site
575540000375	RPB11 interaction site [polypeptide binding]; other site
575540000376	RPB10 interaction site [polypeptide binding]; other site
575540000377	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
575540000378	peripheral dimer interface [polypeptide binding]; other site
575540000379	core dimer interface [polypeptide binding]; other site
575540000380	L10 interface [polypeptide binding]; other site
575540000381	L11 interface [polypeptide binding]; other site
575540000382	putative EF-Tu interaction site [polypeptide binding]; other site
575540000383	putative EF-G interaction site [polypeptide binding]; other site
575540000384	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
575540000385	23S rRNA interface [nucleotide binding]; other site
575540000386	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
575540000387	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
575540000388	mRNA/rRNA interface [nucleotide binding]; other site
575540000389	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
575540000390	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
575540000391	23S rRNA interface [nucleotide binding]; other site
575540000392	L7/L12 interface [polypeptide binding]; other site
575540000393	putative thiostrepton binding site; other site
575540000394	L25 interface [polypeptide binding]; other site
575540000395	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
575540000396	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
575540000397	putative homodimer interface [polypeptide binding]; other site
575540000398	KOW motif; Region: KOW; cl00354
575540000399	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
575540000400	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
575540000401	elongation factor Tu; Reviewed; Region: PRK12735
575540000402	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
575540000403	G1 box; other site
575540000404	GEF interaction site [polypeptide binding]; other site
575540000405	GTP/Mg2+ binding site [chemical binding]; other site
575540000406	Switch I region; other site
575540000407	G2 box; other site
575540000408	G3 box; other site
575540000409	Switch II region; other site
575540000410	G4 box; other site
575540000411	G5 box; other site
575540000412	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
575540000413	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
575540000414	Antibiotic Binding Site [chemical binding]; other site
575540000415	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540000416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000417	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540000418	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
575540000419	TadE-like protein; Region: TadE; cl10688
575540000420	TadE-like protein; Region: TadE; cl10688
575540000421	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
575540000422	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540000423	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
575540000424	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540000425	Walker A/P-loop; other site
575540000426	ATP binding site [chemical binding]; other site
575540000427	Q-loop/lid; other site
575540000428	ABC transporter signature motif; other site
575540000429	Walker B; other site
575540000430	D-loop; other site
575540000431	H-loop/switch region; other site
575540000432	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540000433	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
575540000434	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
575540000435	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
575540000436	amidohydrolase; Region: amidohydrolases; TIGR01891
575540000437	metal binding site [ion binding]; metal-binding site
575540000438	dimer interface [polypeptide binding]; other site
575540000439	Proline dehydrogenase; Region: Pro_dh; cl03282
575540000440	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
575540000441	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
575540000442	Glutamate binding site [chemical binding]; other site
575540000443	homodimer interface [polypeptide binding]; other site
575540000444	NAD binding site [chemical binding]; other site
575540000445	catalytic residues [active]
575540000446	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540000447	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540000448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000449	TPR motif; other site
575540000450	binding surface
575540000451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000452	binding surface
575540000453	TPR motif; other site
575540000454	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540000455	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540000456	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
575540000457	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
575540000458	hinge; other site
575540000459	active site
575540000460	Restriction endonuclease; Region: Mrr_cat; cl00516
575540000461	KpsF/GutQ family protein; Region: kpsF; TIGR00393
575540000462	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
575540000463	putative active site [active]
575540000464	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
575540000465	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
575540000466	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540000467	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
575540000468	SAF domain; Region: SAF; cl00555
575540000469	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
575540000470	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
575540000471	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
575540000472	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
575540000473	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
575540000474	ATP binding site [chemical binding]; other site
575540000475	Walker A motif; other site
575540000476	hexamer interface [polypeptide binding]; other site
575540000477	Walker B motif; other site
575540000478	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
575540000479	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540000480	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540000481	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
575540000482	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540000483	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540000484	DNA binding residues [nucleotide binding]
575540000485	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540000486	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540000487	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540000488	HEAT repeats; Region: HEAT_2; pfam13646
575540000489	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540000490	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
575540000491	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
575540000492	dimerization interface 3.5A [polypeptide binding]; other site
575540000493	active site
575540000494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000495	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
575540000496	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
575540000497	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000498	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
575540000499	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540000500	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
575540000501	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540000502	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540000503	active site
575540000504	ATP binding site [chemical binding]; other site
575540000505	substrate binding site [chemical binding]; other site
575540000506	activation loop (A-loop); other site
575540000507	EVE domain; Region: EVE; cl00728
575540000508	GtrA-like protein; Region: GtrA; cl00971
575540000509	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
575540000510	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
575540000511	Ligand Binding Site [chemical binding]; other site
575540000512	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
575540000513	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
575540000514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000515	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
575540000516	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
575540000517	catalytic triad [active]
575540000518	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
575540000519	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
575540000520	active site
575540000521	HslU subunit interaction site [polypeptide binding]; other site
575540000522	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540000523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540000524	Walker A motif; other site
575540000525	ATP binding site [chemical binding]; other site
575540000526	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540000527	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
575540000528	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540000529	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
575540000530	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
575540000531	B3/4 domain; Region: B3_4; cl11458
575540000532	tRNA synthetase B5 domain; Region: B5; cl08394
575540000533	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
575540000534	dimer interface [polypeptide binding]; other site
575540000535	motif 1; other site
575540000536	motif 3; other site
575540000537	motif 2; other site
575540000538	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
575540000539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540000540	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
575540000541	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
575540000542	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
575540000543	active site
575540000544	metal binding site [ion binding]; metal-binding site
575540000545	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540000546	Sulfatase; Region: Sulfatase; cl10460
575540000547	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000548	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
575540000549	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
575540000550	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
575540000551	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
575540000552	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
575540000553	AMP-binding enzyme; Region: AMP-binding; cl15778
575540000554	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540000555	putative acyl-acceptor binding pocket; other site
575540000556	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540000557	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000558	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000559	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
575540000560	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
575540000561	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
575540000562	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
575540000563	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
575540000564	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
575540000565	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
575540000566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000567	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
575540000568	putative L-serine binding site [chemical binding]; other site
575540000569	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
575540000570	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
575540000571	generic binding surface II; other site
575540000572	generic binding surface I; other site
575540000573	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
575540000574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540000575	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000576	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
575540000577	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540000578	Walker A/P-loop; other site
575540000579	ATP binding site [chemical binding]; other site
575540000580	Q-loop/lid; other site
575540000581	ABC transporter signature motif; other site
575540000582	Walker B; other site
575540000583	D-loop; other site
575540000584	H-loop/switch region; other site
575540000585	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
575540000586	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540000587	FeS/SAM binding site; other site
575540000588	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540000589	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540000590	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540000591	DNA binding residues [nucleotide binding]
575540000592	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
575540000593	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
575540000594	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
575540000595	domain interfaces; other site
575540000596	active site
575540000597	hypothetical protein; Provisional; Region: PRK08912
575540000598	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540000599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540000600	homodimer interface [polypeptide binding]; other site
575540000601	catalytic residue [active]
575540000602	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540000603	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540000604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000605	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540000606	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
575540000607	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540000608	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540000609	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540000610	Predicted peptidase [General function prediction only]; Region: COG4099
575540000611	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000612	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
575540000613	LabA_like proteins; Region: LabA_like/DUF88; cl10034
575540000614	putative metal binding site [ion binding]; other site
575540000615	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540000616	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
575540000617	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540000618	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540000619	catalytic residue [active]
575540000620	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
575540000621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000622	TPR motif; other site
575540000623	SEC-C motif; Region: SEC-C; pfam02810
575540000624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000625	binding surface
575540000626	TPR motif; other site
575540000627	TPR repeat; Region: TPR_11; pfam13414
575540000628	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
575540000629	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
575540000630	G1 box; other site
575540000631	GTP/Mg2+ binding site [chemical binding]; other site
575540000632	Switch I region; other site
575540000633	G2 box; other site
575540000634	Switch II region; other site
575540000635	G3 box; other site
575540000636	G4 box; other site
575540000637	G5 box; other site
575540000638	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
575540000639	G1 box; other site
575540000640	GTP/Mg2+ binding site [chemical binding]; other site
575540000641	Switch I region; other site
575540000642	G2 box; other site
575540000643	G3 box; other site
575540000644	Switch II region; other site
575540000645	G4 box; other site
575540000646	G5 box; other site
575540000647	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
575540000648	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
575540000649	tandem repeat interface [polypeptide binding]; other site
575540000650	oligomer interface [polypeptide binding]; other site
575540000651	active site residues [active]
575540000652	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
575540000653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540000654	Walker A/P-loop; other site
575540000655	ATP binding site [chemical binding]; other site
575540000656	Q-loop/lid; other site
575540000657	ABC transporter signature motif; other site
575540000658	Walker B; other site
575540000659	D-loop; other site
575540000660	H-loop/switch region; other site
575540000661	HSP90 family protein; Provisional; Region: PRK14083
575540000662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540000663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540000664	putative active site [active]
575540000665	PAS fold; Region: PAS_3; pfam08447
575540000666	heme pocket [chemical binding]; other site
575540000667	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
575540000668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540000669	putative active site [active]
575540000670	heme pocket [chemical binding]; other site
575540000671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540000672	dimer interface [polypeptide binding]; other site
575540000673	phosphorylation site [posttranslational modification]
575540000674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540000675	ATP binding site [chemical binding]; other site
575540000676	Mg2+ binding site [ion binding]; other site
575540000677	G-X-G motif; other site
575540000678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
575540000679	Response regulator receiver domain; Region: Response_reg; pfam00072
575540000680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540000681	active site
575540000682	phosphorylation site [posttranslational modification]
575540000683	intermolecular recognition site; other site
575540000684	dimerization interface [polypeptide binding]; other site
575540000685	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
575540000686	polysaccharide export protein Wza; Provisional; Region: PRK15078
575540000687	SLBB domain; Region: SLBB; pfam10531
575540000688	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
575540000689	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540000690	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
575540000691	pteridine reductase; Provisional; Region: PRK09135
575540000692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000693	NAD(P) binding site [chemical binding]; other site
575540000694	active site
575540000695	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
575540000696	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
575540000697	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000698	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000699	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000700	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540000701	DinB superfamily; Region: DinB_2; pfam12867
575540000702	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
575540000703	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540000704	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540000705	active site
575540000706	ATP binding site [chemical binding]; other site
575540000707	substrate binding site [chemical binding]; other site
575540000708	activation loop (A-loop); other site
575540000709	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
575540000710	catalytic motif [active]
575540000711	Catalytic residue [active]
575540000712	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540000713	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
575540000714	catalytic motif [active]
575540000715	Catalytic residue [active]
575540000716	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
575540000717	protein binding site [polypeptide binding]; other site
575540000718	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
575540000719	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
575540000720	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540000721	metal ion-dependent adhesion site (MIDAS); other site
575540000722	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
575540000723	putative ligand binding site [chemical binding]; other site
575540000724	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
575540000725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540000726	active site
575540000727	phosphorylation site [posttranslational modification]
575540000728	intermolecular recognition site; other site
575540000729	dimerization interface [polypeptide binding]; other site
575540000730	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540000731	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
575540000732	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
575540000733	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
575540000734	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
575540000735	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000736	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
575540000737	active site
575540000738	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
575540000739	elongation factor P; Validated; Region: PRK00529
575540000740	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
575540000741	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
575540000742	RNA binding site [nucleotide binding]; other site
575540000743	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
575540000744	RNA binding site [nucleotide binding]; other site
575540000745	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540000746	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540000747	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540000748	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540000749	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
575540000750	Right handed beta helix region; Region: Beta_helix; pfam13229
575540000751	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
575540000752	Protein of unknown function, DUF655; Region: DUF655; pfam04919
575540000753	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540000754	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540000755	active site
575540000756	ATP binding site [chemical binding]; other site
575540000757	substrate binding site [chemical binding]; other site
575540000758	activation loop (A-loop); other site
575540000759	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
575540000760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000761	binding surface
575540000762	TPR motif; other site
575540000763	TPR repeat; Region: TPR_11; pfam13414
575540000764	TPR repeat; Region: TPR_11; pfam13414
575540000765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000766	binding surface
575540000767	TPR motif; other site
575540000768	TPR repeat; Region: TPR_11; pfam13414
575540000769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000770	binding surface
575540000771	TPR motif; other site
575540000772	TPR repeat; Region: TPR_11; pfam13414
575540000773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000774	binding surface
575540000775	TPR motif; other site
575540000776	TPR repeat; Region: TPR_11; pfam13414
575540000777	TPR repeat; Region: TPR_11; pfam13414
575540000778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540000779	binding surface
575540000780	TPR motif; other site
575540000781	TPR repeat; Region: TPR_11; pfam13414
575540000782	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
575540000783	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
575540000784	catalytic residue [active]
575540000785	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
575540000786	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
575540000787	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
575540000788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540000789	Walker A motif; other site
575540000790	ATP binding site [chemical binding]; other site
575540000791	Walker B motif; other site
575540000792	arginine finger; other site
575540000793	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
575540000794	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
575540000795	HEAT repeats; Region: HEAT_2; pfam13646
575540000796	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
575540000797	DNA binding residues [nucleotide binding]
575540000798	Response regulator receiver domain; Region: Response_reg; pfam00072
575540000799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540000800	active site
575540000801	phosphorylation site [posttranslational modification]
575540000802	intermolecular recognition site; other site
575540000803	dimerization interface [polypeptide binding]; other site
575540000804	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
575540000805	trimer interface [polypeptide binding]; other site
575540000806	dimer interface [polypeptide binding]; other site
575540000807	putative active site [active]
575540000808	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
575540000809	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
575540000810	substrate binding pocket [chemical binding]; other site
575540000811	chain length determination region; other site
575540000812	substrate-Mg2+ binding site; other site
575540000813	catalytic residues [active]
575540000814	aspartate-rich region 1; other site
575540000815	active site lid residues [active]
575540000816	aspartate-rich region 2; other site
575540000817	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
575540000818	C-terminal peptidase (prc); Region: prc; TIGR00225
575540000819	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540000820	protein binding site [polypeptide binding]; other site
575540000821	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
575540000822	Catalytic dyad [active]
575540000823	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
575540000824	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
575540000825	putative [4Fe-4S] binding site [ion binding]; other site
575540000826	putative molybdopterin cofactor binding site [chemical binding]; other site
575540000827	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
575540000828	putative molybdopterin cofactor binding site; other site
575540000829	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540000830	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
575540000831	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
575540000832	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
575540000833	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540000834	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
575540000835	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540000836	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
575540000837	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
575540000838	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540000839	active site
575540000840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540000841	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540000842	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540000843	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540000844	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
575540000845	ketol-acid reductoisomerase; Provisional; Region: PRK05479
575540000846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000847	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
575540000848	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
575540000849	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
575540000850	putative valine binding site [chemical binding]; other site
575540000851	dimer interface [polypeptide binding]; other site
575540000852	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
575540000853	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
575540000854	Glucuronate isomerase; Region: UxaC; cl00829
575540000855	Sulfatase; Region: Sulfatase; cl10460
575540000856	Sulfatase; Region: Sulfatase; cl10460
575540000857	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540000858	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540000859	mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965
575540000860	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
575540000861	active site
575540000862	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
575540000863	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
575540000864	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
575540000865	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
575540000866	Protein of unknown function, DUF486; Region: DUF486; cl01236
575540000867	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
575540000868	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
575540000869	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540000870	DsrE/DsrF-like family; Region: DrsE; cl00672
575540000871	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540000872	Sulfatase; Region: Sulfatase; cl10460
575540000873	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
575540000874	putative ADP-ribose binding site [chemical binding]; other site
575540000875	aminotransferase; Validated; Region: PRK08175
575540000876	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540000877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540000878	homodimer interface [polypeptide binding]; other site
575540000879	catalytic residue [active]
575540000880	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
575540000881	PPIC-type PPIASE domain; Region: Rotamase; cl08278
575540000882	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
575540000883	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
575540000884	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
575540000885	IHF - DNA interface [nucleotide binding]; other site
575540000886	IHF dimer interface [polypeptide binding]; other site
575540000887	Cupin domain; Region: Cupin_2; cl09118
575540000888	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540000889	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540000890	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
575540000891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540000892	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
575540000893	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540000894	Cytochrome c; Region: Cytochrom_C; cl11414
575540000895	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540000896	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
575540000897	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540000898	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
575540000899	putative catalytic residue [active]
575540000900	Haem-binding domain; Region: Haem_bd; pfam14376
575540000901	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
575540000902	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
575540000903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540000904	FeS/SAM binding site; other site
575540000905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
575540000906	putative active site [active]
575540000907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000908	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
575540000909	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
575540000910	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
575540000911	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
575540000912	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
575540000913	trimer interface [polypeptide binding]; other site
575540000914	active site
575540000915	UDP-GlcNAc binding site [chemical binding]; other site
575540000916	lipid binding site [chemical binding]; lipid-binding site
575540000917	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
575540000918	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
575540000919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540000920	putative active site [active]
575540000921	heme pocket [chemical binding]; other site
575540000922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540000923	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
575540000924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540000925	dimer interface [polypeptide binding]; other site
575540000926	phosphorylation site [posttranslational modification]
575540000927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540000928	ATP binding site [chemical binding]; other site
575540000929	Mg2+ binding site [ion binding]; other site
575540000930	G-X-G motif; other site
575540000931	Response regulator receiver domain; Region: Response_reg; pfam00072
575540000932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540000933	active site
575540000934	phosphorylation site [posttranslational modification]
575540000935	intermolecular recognition site; other site
575540000936	dimerization interface [polypeptide binding]; other site
575540000937	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
575540000938	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540000939	motif II; other site
575540000940	UGMP family protein; Validated; Region: PRK09604
575540000941	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
575540000942	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
575540000943	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
575540000944	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
575540000945	active site
575540000946	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
575540000947	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
575540000948	trimer interface I [polypeptide binding]; other site
575540000949	putative substrate binding pocket [chemical binding]; other site
575540000950	trimer interface II [polypeptide binding]; other site
575540000951	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
575540000952	domain_subunit interface; other site
575540000953	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
575540000954	putative acyl-acceptor binding pocket; other site
575540000955	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540000956	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540000957	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540000958	dimer interface [polypeptide binding]; other site
575540000959	active site
575540000960	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
575540000961	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
575540000962	trimer interface [polypeptide binding]; other site
575540000963	active site
575540000964	substrate binding site [chemical binding]; other site
575540000965	CoA binding site [chemical binding]; other site
575540000966	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540000967	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540000968	motif 1; other site
575540000969	dimer interface [polypeptide binding]; other site
575540000970	active site
575540000971	motif 2; other site
575540000972	motif 3; other site
575540000973	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540000974	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540000975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540000976	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540000977	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540000978	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
575540000979	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540000980	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540000981	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540000982	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
575540000983	phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639
575540000984	active site
575540000985	substrate binding site [chemical binding]; other site
575540000986	cosubstrate binding site; other site
575540000987	catalytic site [active]
575540000988	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
575540000989	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540000990	active site
575540000991	HIGH motif; other site
575540000992	nucleotide binding site [chemical binding]; other site
575540000993	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
575540000994	active site
575540000995	KMSKS motif; other site
575540000996	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
575540000997	tRNA binding surface [nucleotide binding]; other site
575540000998	anticodon binding site; other site
575540000999	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
575540001000	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
575540001001	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
575540001002	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001003	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
575540001004	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
575540001005	Cytochrome c; Region: Cytochrom_C; cl11414
575540001006	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
575540001007	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
575540001008	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
575540001009	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
575540001010	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
575540001011	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540001012	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
575540001013	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540001014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540001015	homodimer interface [polypeptide binding]; other site
575540001016	catalytic residue [active]
575540001017	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
575540001018	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
575540001019	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
575540001020	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540001021	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540001022	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
575540001023	substrate binding site [chemical binding]; other site
575540001024	THF binding site; other site
575540001025	zinc-binding site [ion binding]; other site
575540001026	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540001027	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
575540001028	D-xylulose kinase; Region: XylB; TIGR01312
575540001029	N- and C-terminal domain interface [polypeptide binding]; other site
575540001030	active site
575540001031	catalytic site [active]
575540001032	metal binding site [ion binding]; metal-binding site
575540001033	xylulose binding site [chemical binding]; other site
575540001034	putative ATP binding site [chemical binding]; other site
575540001035	homodimer interface [polypeptide binding]; other site
575540001036	AsmA-like C-terminal region; Region: AsmA_2; cl15864
575540001037	AsmA-like C-terminal region; Region: AsmA_2; cl15864
575540001038	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
575540001039	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
575540001040	Ligand binding site; other site
575540001041	Putative Catalytic site; other site
575540001042	DXD motif; other site
575540001043	Predicted integral membrane protein [Function unknown]; Region: COG0392
575540001044	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
575540001045	Sulfate transporter family; Region: Sulfate_transp; cl15842
575540001046	Sulfate transporter family; Region: Sulfate_transp; cl15842
575540001047	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
575540001048	4Fe-4S binding domain; Region: Fer4; cl02805
575540001049	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
575540001050	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
575540001051	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
575540001052	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589
575540001053	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540001054	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
575540001055	NADH dehydrogenase; Region: NADHdh; cl00469
575540001056	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540001057	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
575540001058	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
575540001059	active site
575540001060	phosphorylation site [posttranslational modification]
575540001061	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540001062	dimerization interface [polypeptide binding]; other site
575540001063	putative DNA binding site [nucleotide binding]; other site
575540001064	putative Zn2+ binding site [ion binding]; other site
575540001065	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540001066	anti sigma factor interaction site; other site
575540001067	regulatory phosphorylation site [posttranslational modification]; other site
575540001068	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
575540001069	MutS domain I; Region: MutS_I; pfam01624
575540001070	MutS domain II; Region: MutS_II; pfam05188
575540001071	MutS family domain IV; Region: MutS_IV; pfam05190
575540001072	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
575540001073	Walker A/P-loop; other site
575540001074	ATP binding site [chemical binding]; other site
575540001075	Q-loop/lid; other site
575540001076	ABC transporter signature motif; other site
575540001077	Walker B; other site
575540001078	D-loop; other site
575540001079	H-loop/switch region; other site
575540001080	Family description; Region: VCBS; pfam13517
575540001081	Family description; Region: VCBS; pfam13517
575540001082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540001083	TPR motif; other site
575540001084	TPR repeat; Region: TPR_11; pfam13414
575540001085	binding surface
575540001086	TPR repeat; Region: TPR_11; pfam13414
575540001087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540001088	binding surface
575540001089	TPR motif; other site
575540001090	TPR repeat; Region: TPR_11; pfam13414
575540001091	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540001092	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540001093	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
575540001094	putative NAD(P) binding site [chemical binding]; other site
575540001095	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
575540001096	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
575540001097	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
575540001098	Substrate binding site; other site
575540001099	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
575540001100	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
575540001101	substrate binding site; other site
575540001102	dimerization interface; other site
575540001103	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540001104	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540001105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001106	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001107	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001108	Leucine-rich repeats; other site
575540001109	Substrate binding site [chemical binding]; other site
575540001110	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001111	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001112	Leucine-rich repeats; other site
575540001113	Substrate binding site [chemical binding]; other site
575540001114	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001115	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001116	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001117	Substrate binding site [chemical binding]; other site
575540001118	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
575540001119	Low-spin heme binding site [chemical binding]; other site
575540001120	D-pathway; other site
575540001121	Putative water exit pathway; other site
575540001122	Binuclear center (active site) [active]
575540001123	K-pathway; other site
575540001124	Putative proton exit pathway; other site
575540001125	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
575540001126	Cytochrome c; Region: Cytochrom_C; cl11414
575540001127	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
575540001128	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540001129	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540001130	Bacterial Ig-like domain; Region: Big_5; cl01012
575540001131	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
575540001132	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
575540001133	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
575540001134	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
575540001135	putative homotetramer interface [polypeptide binding]; other site
575540001136	putative homodimer interface [polypeptide binding]; other site
575540001137	putative allosteric switch controlling residues; other site
575540001138	putative metal binding site [ion binding]; other site
575540001139	putative homodimer-homodimer interface [polypeptide binding]; other site
575540001140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540001141	dimer interface [polypeptide binding]; other site
575540001142	conserved gate region; other site
575540001143	putative PBP binding loops; other site
575540001144	ABC-ATPase subunit interface; other site
575540001145	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
575540001146	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
575540001147	Walker A/P-loop; other site
575540001148	ATP binding site [chemical binding]; other site
575540001149	Q-loop/lid; other site
575540001150	ABC transporter signature motif; other site
575540001151	Walker B; other site
575540001152	D-loop; other site
575540001153	H-loop/switch region; other site
575540001154	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540001155	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
575540001156	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
575540001157	nucleotide binding site [chemical binding]; other site
575540001158	substrate binding site [chemical binding]; other site
575540001159	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
575540001160	nucleotide binding site [chemical binding]; other site
575540001161	substrate binding site [chemical binding]; other site
575540001162	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540001163	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540001164	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
575540001165	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
575540001166	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540001167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001168	Walker A motif; other site
575540001169	ATP binding site [chemical binding]; other site
575540001170	Walker B motif; other site
575540001171	arginine finger; other site
575540001172	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540001173	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540001174	metal ion-dependent adhesion site (MIDAS); other site
575540001175	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540001176	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540001177	metal ion-dependent adhesion site (MIDAS); other site
575540001178	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540001179	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
575540001180	E3 interaction surface; other site
575540001181	lipoyl attachment site [posttranslational modification]; other site
575540001182	e3 binding domain; Region: E3_binding; pfam02817
575540001183	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
575540001184	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
575540001185	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
575540001186	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
575540001187	PYR/PP interface [polypeptide binding]; other site
575540001188	dimer interface [polypeptide binding]; other site
575540001189	TPP binding site [chemical binding]; other site
575540001190	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
575540001191	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
575540001192	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
575540001193	tetramer interface [polypeptide binding]; other site
575540001194	TPP-binding site [chemical binding]; other site
575540001195	heterodimer interface [polypeptide binding]; other site
575540001196	phosphorylation loop region [posttranslational modification]
575540001197	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
575540001198	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
575540001199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001200	Walker A motif; other site
575540001201	ATP binding site [chemical binding]; other site
575540001202	Walker B motif; other site
575540001203	arginine finger; other site
575540001204	Helix-turn-helix domains; Region: HTH; cl00088
575540001205	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
575540001206	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
575540001207	NAD binding site [chemical binding]; other site
575540001208	substrate binding site [chemical binding]; other site
575540001209	catalytic Zn binding site [ion binding]; other site
575540001210	tetramer interface [polypeptide binding]; other site
575540001211	structural Zn binding site [ion binding]; other site
575540001212	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
575540001213	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
575540001214	NAD(P) binding site [chemical binding]; other site
575540001215	catalytic residues [active]
575540001216	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
575540001217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001218	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
575540001219	Walker A motif; other site
575540001220	ATP binding site [chemical binding]; other site
575540001221	Walker B motif; other site
575540001222	arginine finger; other site
575540001223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001224	Walker A motif; other site
575540001225	ATP binding site [chemical binding]; other site
575540001226	Walker B motif; other site
575540001227	arginine finger; other site
575540001228	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
575540001229	putative dimer interface [polypeptide binding]; other site
575540001230	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540001231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540001232	active site
575540001233	phosphorylation site [posttranslational modification]
575540001234	intermolecular recognition site; other site
575540001235	dimerization interface [polypeptide binding]; other site
575540001236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001237	Walker A motif; other site
575540001238	ATP binding site [chemical binding]; other site
575540001239	Walker B motif; other site
575540001240	arginine finger; other site
575540001241	Helix-turn-helix domains; Region: HTH; cl00088
575540001242	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
575540001243	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
575540001244	metal-binding site [ion binding]
575540001245	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540001246	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540001247	Sulfatase; Region: Sulfatase; cl10460
575540001248	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540001249	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
575540001250	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540001251	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
575540001252	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540001253	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540001254	DNA binding residues [nucleotide binding]
575540001255	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540001256	phosphopeptide binding site; other site
575540001257	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540001258	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540001259	active site
575540001260	ATP binding site [chemical binding]; other site
575540001261	substrate binding site [chemical binding]; other site
575540001262	activation loop (A-loop); other site
575540001263	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
575540001264	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
575540001265	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
575540001266	putative Iron-sulfur protein interface [polypeptide binding]; other site
575540001267	proximal heme binding site [chemical binding]; other site
575540001268	putative dimer interface [polypeptide binding]; other site
575540001269	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
575540001270	distal heme binding site [chemical binding]; other site
575540001271	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
575540001272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001273	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
575540001274	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
575540001275	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
575540001276	4Fe-4S binding domain; Region: Fer4; cl02805
575540001277	PEP-CTERM motif; Region: VPEP; cl15443
575540001278	Global regulator protein family; Region: CsrA; cl00670
575540001279	FliW protein; Region: FliW; cl00740
575540001280	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
575540001281	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540001282	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
575540001283	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
575540001284	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
575540001285	active site
575540001286	catalytic site [active]
575540001287	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
575540001288	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540001289	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540001290	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
575540001291	Acyl transferase domain; Region: Acyl_transf_1; cl08282
575540001292	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
575540001293	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
575540001294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001295	NAD(P) binding site [chemical binding]; other site
575540001296	active site
575540001297	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540001298	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
575540001299	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
575540001300	homodimer interface [polypeptide binding]; other site
575540001301	substrate-cofactor binding pocket; other site
575540001302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540001303	catalytic residue [active]
575540001304	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
575540001305	catalytic residues [active]
575540001306	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
575540001307	active site
575540001308	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
575540001309	Peptidase family U32; Region: Peptidase_U32; cl03113
575540001310	Collagenase; Region: DUF3656; pfam12392
575540001311	Peptidase family U32; Region: Peptidase_U32; cl03113
575540001312	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540001313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001314	LamB/YcsF family; Region: LamB_YcsF; cl00664
575540001315	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
575540001316	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
575540001317	Predicted permease; Region: DUF318; pfam03773
575540001318	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
575540001319	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
575540001320	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
575540001321	putative trimer interface [polypeptide binding]; other site
575540001322	putative CoA binding site [chemical binding]; other site
575540001323	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
575540001324	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
575540001325	glutaminase active site [active]
575540001326	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
575540001327	dimer interface [polypeptide binding]; other site
575540001328	active site
575540001329	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
575540001330	dimer interface [polypeptide binding]; other site
575540001331	active site
575540001332	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540001333	active site
575540001334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001335	S-adenosylmethionine binding site [chemical binding]; other site
575540001336	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
575540001337	Flavoprotein; Region: Flavoprotein; cl08021
575540001338	histidyl-tRNA synthetase; Region: hisS; TIGR00442
575540001339	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
575540001340	dimer interface [polypeptide binding]; other site
575540001341	motif 1; other site
575540001342	motif 2; other site
575540001343	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540001344	motif 3; other site
575540001345	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
575540001346	anticodon binding site; other site
575540001347	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
575540001348	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
575540001349	dimer interface [polypeptide binding]; other site
575540001350	motif 1; other site
575540001351	motif 2; other site
575540001352	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540001353	active site
575540001354	motif 3; other site
575540001355	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
575540001356	ATP phosphoribosyltransferase; Region: HisG; cl15266
575540001357	tellurite resistance protein TehB; Provisional; Region: PRK11207
575540001358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001359	S-adenosylmethionine binding site [chemical binding]; other site
575540001360	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
575540001361	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
575540001362	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
575540001363	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
575540001364	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
575540001365	23S rRNA binding site [nucleotide binding]; other site
575540001366	L21 binding site [polypeptide binding]; other site
575540001367	L13 binding site [polypeptide binding]; other site
575540001368	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
575540001369	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
575540001370	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
575540001371	dimer interface [polypeptide binding]; other site
575540001372	motif 1; other site
575540001373	active site
575540001374	motif 2; other site
575540001375	motif 3; other site
575540001376	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
575540001377	putative acyl-acceptor binding pocket; other site
575540001378	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001379	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001380	Ferritin-like domain; Region: Ferritin; pfam00210
575540001381	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
575540001382	dimerization interface [polypeptide binding]; other site
575540001383	DPS ferroxidase diiron center [ion binding]; other site
575540001384	ion pore; other site
575540001385	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
575540001386	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
575540001387	active site
575540001388	Zn binding site [ion binding]; other site
575540001389	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
575540001390	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540001391	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
575540001392	catalytic triad [active]
575540001393	conserved cis-peptide bond; other site
575540001394	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
575540001395	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540001396	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
575540001397	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540001398	metal ion-dependent adhesion site (MIDAS); other site
575540001399	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540001400	phosphopeptide binding site; other site
575540001401	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
575540001402	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
575540001403	[2Fe-2S] cluster binding site [ion binding]; other site
575540001404	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
575540001405	putative alpha subunit interface [polypeptide binding]; other site
575540001406	putative active site [active]
575540001407	putative substrate binding site [chemical binding]; other site
575540001408	Fe binding site [ion binding]; other site
575540001409	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
575540001410	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
575540001411	catalytic residues [active]
575540001412	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
575540001413	active site
575540001414	trimer interface [polypeptide binding]; other site
575540001415	allosteric site; other site
575540001416	active site lid [active]
575540001417	hexamer (dimer of trimers) interface [polypeptide binding]; other site
575540001418	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
575540001419	putative active site [active]
575540001420	Cytochrome c; Region: Cytochrom_C; cl11414
575540001421	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540001422	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540001423	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
575540001424	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
575540001425	RNA binding surface [nucleotide binding]; other site
575540001426	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
575540001427	active site
575540001428	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
575540001429	active site
575540001430	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
575540001431	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540001432	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540001433	active site
575540001434	ATP binding site [chemical binding]; other site
575540001435	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540001436	substrate binding site [chemical binding]; other site
575540001437	activation loop (A-loop); other site
575540001438	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
575540001439	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
575540001440	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
575540001441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001442	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
575540001443	NAD(P) binding site [chemical binding]; other site
575540001444	active site
575540001445	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001446	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001447	Leucine-rich repeats; other site
575540001448	Substrate binding site [chemical binding]; other site
575540001449	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
575540001450	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
575540001451	active site
575540001452	dimer interface [polypeptide binding]; other site
575540001453	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
575540001454	Ligand Binding Site [chemical binding]; other site
575540001455	Molecular Tunnel; other site
575540001456	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540001457	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
575540001458	metal binding site [ion binding]; metal-binding site
575540001459	Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378
575540001460	substrate binding pocket [chemical binding]; other site
575540001461	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
575540001462	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
575540001463	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
575540001464	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
575540001465	Helix-turn-helix domains; Region: HTH; cl00088
575540001466	Bifunctional nuclease; Region: DNase-RNase; cl00553
575540001467	GH3 auxin-responsive promoter; Region: GH3; cl04006
575540001468	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540001469	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540001470	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540001471	dimer interface [polypeptide binding]; other site
575540001472	active site
575540001473	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540001474	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540001475	dimer interface [polypeptide binding]; other site
575540001476	active site
575540001477	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
575540001478	active site 2 [active]
575540001479	active site 1 [active]
575540001480	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540001481	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
575540001482	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
575540001483	translocation protein TolB; Provisional; Region: tolB; PRK00178
575540001484	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
575540001485	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
575540001486	FTR, proximal lobe; Region: FTR_C; pfam02741
575540001487	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
575540001488	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540001489	active site
575540001490	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
575540001491	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
575540001492	purine monophosphate binding site [chemical binding]; other site
575540001493	dimer interface [polypeptide binding]; other site
575540001494	putative catalytic residues [active]
575540001495	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
575540001496	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
575540001497	classical (c) SDRs; Region: SDR_c; cd05233
575540001498	NAD(P) binding site [chemical binding]; other site
575540001499	active site
575540001500	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
575540001501	active site
575540001502	catalytic residues [active]
575540001503	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
575540001504	Ligand binding site; other site
575540001505	oligomer interface; other site
575540001506	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540001507	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
575540001508	putative ADP-binding pocket [chemical binding]; other site
575540001509	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
575540001510	active site
575540001511	dimerization interface [polypeptide binding]; other site
575540001512	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
575540001513	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
575540001514	chorismate binding enzyme; Region: Chorismate_bind; cl10555
575540001515	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540001516	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540001517	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540001518	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540001519	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
575540001520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001521	Walker A motif; other site
575540001522	ATP binding site [chemical binding]; other site
575540001523	Walker B motif; other site
575540001524	arginine finger; other site
575540001525	Peptidase family M41; Region: Peptidase_M41; pfam01434
575540001526	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
575540001527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540001528	putative active site [active]
575540001529	heme pocket [chemical binding]; other site
575540001530	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540001531	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
575540001532	Helix-turn-helix domains; Region: HTH; cl00088
575540001533	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
575540001534	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
575540001535	Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951
575540001536	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474
575540001537	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
575540001538	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
575540001539	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
575540001540	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
575540001541	alpha subunit interaction interface [polypeptide binding]; other site
575540001542	Walker A motif; other site
575540001543	ATP binding site [chemical binding]; other site
575540001544	Walker B motif; other site
575540001545	inhibitor binding site; inhibition site
575540001546	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
575540001547	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
575540001548	ATP synthase; Region: ATP-synt; cl00365
575540001549	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
575540001550	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
575540001551	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
575540001552	beta subunit interaction interface [polypeptide binding]; other site
575540001553	Walker A motif; other site
575540001554	ATP binding site [chemical binding]; other site
575540001555	Walker B motif; other site
575540001556	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
575540001557	Plant ATP synthase F0; Region: YMF19; cl07975
575540001558	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
575540001559	Plant ATP synthase F0; Region: YMF19; cl07975
575540001560	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
575540001561	ATP synthase A chain; Region: ATP-synt_A; cl00413
575540001562	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
575540001563	Cytochrome c; Region: Cytochrom_C; cl11414
575540001564	Cytochrome c; Region: Cytochrom_C; cl11414
575540001565	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
575540001566	D-pathway; other site
575540001567	Low-spin heme binding site [chemical binding]; other site
575540001568	Putative water exit pathway; other site
575540001569	Binuclear center (active site) [active]
575540001570	K-pathway; other site
575540001571	Putative proton exit pathway; other site
575540001572	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
575540001573	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
575540001574	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540001575	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540001576	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
575540001577	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
575540001578	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
575540001579	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540001580	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540001581	DNA interaction; other site
575540001582	Metal-binding active site; metal-binding site
575540001583	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
575540001584	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540001585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001586	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540001587	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540001588	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
575540001589	N-carbamolyputrescine amidase; Region: PLN02747
575540001590	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
575540001591	putative active site; other site
575540001592	catalytic triad [active]
575540001593	putative dimer interface [polypeptide binding]; other site
575540001594	agmatine deiminase; Region: agmatine_aguA; TIGR03380
575540001595	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
575540001596	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
575540001597	putative catalytic residue [active]
575540001598	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540001599	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
575540001600	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540001601	catalytic residues [active]
575540001602	peptide chain release factor 1; Validated; Region: prfA; PRK00591
575540001603	RF-1 domain; Region: RF-1; cl02875
575540001604	RF-1 domain; Region: RF-1; cl02875
575540001605	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
575540001606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001607	S-adenosylmethionine binding site [chemical binding]; other site
575540001608	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
575540001609	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
575540001610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001611	Walker A motif; other site
575540001612	ATP binding site [chemical binding]; other site
575540001613	Walker B motif; other site
575540001614	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
575540001615	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540001616	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
575540001617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540001618	catalytic residue [active]
575540001619	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
575540001620	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
575540001621	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
575540001622	aspartate kinase; Provisional; Region: PRK07431
575540001623	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
575540001624	putative nucleotide binding site [chemical binding]; other site
575540001625	putative catalytic residues [active]
575540001626	putative Mg ion binding site [ion binding]; other site
575540001627	putative aspartate binding site [chemical binding]; other site
575540001628	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
575540001629	putative allosteric regulatory site; other site
575540001630	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
575540001631	putative allosteric regulatory residue; other site
575540001632	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
575540001633	putative allosteric regulatory site; other site
575540001634	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
575540001635	putative allosteric regulatory residue; other site
575540001636	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
575540001637	Sulfatase; Region: Sulfatase; cl10460
575540001638	Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2
575540001639	aspartate aminotransferase; Provisional; Region: PRK05764
575540001640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540001641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540001642	homodimer interface [polypeptide binding]; other site
575540001643	catalytic residue [active]
575540001644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001645	S-adenosylmethionine binding site [chemical binding]; other site
575540001646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001647	S-adenosylmethionine binding site [chemical binding]; other site
575540001648	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
575540001649	putative active site [active]
575540001650	putative metal binding site [ion binding]; other site
575540001651	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540001652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001653	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540001654	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
575540001655	Uncharacterized conserved protein [Function unknown]; Region: COG2006
575540001656	Uncharacterized conserved protein [Function unknown]; Region: COG2006
575540001657	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540001658	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
575540001659	active site
575540001660	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540001661	Domain of unknown function (DUF336); Region: DUF336; cl01249
575540001662	RF-1 domain; Region: RF-1; cl02875
575540001663	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540001664	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540001665	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540001666	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540001667	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
575540001668	active site
575540001669	Zn binding site [ion binding]; other site
575540001670	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
575540001671	Zn binding site [ion binding]; other site
575540001672	Surface antigen; Region: Bac_surface_Ag; cl03097
575540001673	pyruvate carboxylase; Reviewed; Region: PRK12999
575540001674	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
575540001675	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540001676	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
575540001677	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
575540001678	active site
575540001679	catalytic residues [active]
575540001680	metal binding site [ion binding]; metal-binding site
575540001681	homodimer binding site [polypeptide binding]; other site
575540001682	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
575540001683	carboxyltransferase (CT) interaction site; other site
575540001684	biotinylation site [posttranslational modification]; other site
575540001685	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540001686	catalytic residues [active]
575540001687	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
575540001688	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540001689	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
575540001690	Probable Catalytic site; other site
575540001691	metal-binding site
575540001692	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540001693	catalytic residues [active]
575540001694	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540001695	catalytic residues [active]
575540001696	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540001697	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
575540001698	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540001699	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540001700	protein binding site [polypeptide binding]; other site
575540001701	Tetrahydromethanopterin S-methyltransferase, subunit A [Coenzyme metabolism]; Region: MtrA; COG4063
575540001702	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540001703	catalytic residues [active]
575540001704	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
575540001705	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
575540001706	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540001707	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001708	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540001709	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001710	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001711	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
575540001712	Protein export membrane protein; Region: SecD_SecF; cl14618
575540001713	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
575540001714	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540001715	Walker A/P-loop; other site
575540001716	ATP binding site [chemical binding]; other site
575540001717	Q-loop/lid; other site
575540001718	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
575540001719	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540001720	ABC transporter signature motif; other site
575540001721	Walker B; other site
575540001722	D-loop; other site
575540001723	H-loop/switch region; other site
575540001724	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540001725	Walker A/P-loop; other site
575540001726	ATP binding site [chemical binding]; other site
575540001727	Q-loop/lid; other site
575540001728	ABC transporter signature motif; other site
575540001729	Walker B; other site
575540001730	D-loop; other site
575540001731	H-loop/switch region; other site
575540001732	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
575540001733	putative acyl-acceptor binding pocket; other site
575540001734	cytidylate kinase; Provisional; Region: cmk; PRK00023
575540001735	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
575540001736	CMP-binding site; other site
575540001737	The sites determining sugar specificity; other site
575540001738	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
575540001739	Uncharacterized conserved protein [Function unknown]; Region: COG2006
575540001740	Domain of unknown function (DUF362); Region: DUF362; pfam04015
575540001741	4Fe-4S binding domain; Region: Fer4_5; pfam12801
575540001742	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
575540001743	4Fe-4S binding domain; Region: Fer4_5; pfam12801
575540001744	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
575540001745	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
575540001746	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
575540001747	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
575540001748	4Fe-4S binding domain; Region: Fer4; cl02805
575540001749	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
575540001750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001751	Walker A motif; other site
575540001752	ATP binding site [chemical binding]; other site
575540001753	Walker B motif; other site
575540001754	arginine finger; other site
575540001755	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
575540001756	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
575540001757	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
575540001758	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
575540001759	Walker A/P-loop; other site
575540001760	ATP binding site [chemical binding]; other site
575540001761	Q-loop/lid; other site
575540001762	ABC transporter signature motif; other site
575540001763	Walker B; other site
575540001764	D-loop; other site
575540001765	H-loop/switch region; other site
575540001766	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
575540001767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540001768	dimer interface [polypeptide binding]; other site
575540001769	conserved gate region; other site
575540001770	putative PBP binding loops; other site
575540001771	ABC-ATPase subunit interface; other site
575540001772	NMT1/THI5 like; Region: NMT1; pfam09084
575540001773	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520
575540001774	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
575540001775	active site
575540001776	catalytic residue [active]
575540001777	dimer interface [polypeptide binding]; other site
575540001778	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
575540001779	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
575540001780	shikimate binding site; other site
575540001781	NAD(P) binding site [chemical binding]; other site
575540001782	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
575540001783	ADP binding site [chemical binding]; other site
575540001784	magnesium binding site [ion binding]; other site
575540001785	putative shikimate binding site; other site
575540001786	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
575540001787	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
575540001788	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540001789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
575540001790	active site
575540001791	phosphorylation site [posttranslational modification]
575540001792	intermolecular recognition site; other site
575540001793	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
575540001794	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
575540001795	putative dimer interface [polypeptide binding]; other site
575540001796	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
575540001797	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
575540001798	putative dimer interface [polypeptide binding]; other site
575540001799	ornithine carbamoyltransferase; Provisional; Region: PRK00779
575540001800	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
575540001801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001802	acetylornithine aminotransferase; Provisional; Region: PRK02627
575540001803	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
575540001804	inhibitor-cofactor binding pocket; inhibition site
575540001805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540001806	catalytic residue [active]
575540001807	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
575540001808	feedback inhibition sensing region; other site
575540001809	homohexameric interface [polypeptide binding]; other site
575540001810	nucleotide binding site [chemical binding]; other site
575540001811	N-acetyl-L-glutamate binding site [chemical binding]; other site
575540001812	ACT domain-containing protein [General function prediction only]; Region: COG4747
575540001813	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
575540001814	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
575540001815	nudix motif; other site
575540001816	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
575540001817	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
575540001818	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
575540001819	adenylosuccinate lyase; Region: purB; TIGR00928
575540001820	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
575540001821	tetramer interface [polypeptide binding]; other site
575540001822	active site
575540001823	Creatinine amidohydrolase; Region: Creatininase; cl00618
575540001824	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
575540001825	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
575540001826	Cu(I) binding site [ion binding]; other site
575540001827	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
575540001828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001829	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
575540001830	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
575540001831	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
575540001832	substrate binding pocket [chemical binding]; other site
575540001833	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
575540001834	B12 binding site [chemical binding]; other site
575540001835	cobalt ligand [ion binding]; other site
575540001836	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
575540001837	signal recognition particle protein; Provisional; Region: PRK10867
575540001838	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
575540001839	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
575540001840	P loop; other site
575540001841	GTP binding site [chemical binding]; other site
575540001842	Signal peptide binding domain; Region: SRP_SPB; pfam02978
575540001843	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
575540001844	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
575540001845	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
575540001846	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
575540001847	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
575540001848	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
575540001849	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
575540001850	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
575540001851	putative dimer interface [polypeptide binding]; other site
575540001852	[2Fe-2S] cluster binding site [ion binding]; other site
575540001853	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
575540001854	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
575540001855	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
575540001856	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
575540001857	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540001858	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
575540001859	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
575540001860	NAD(P) binding site [chemical binding]; other site
575540001861	catalytic residues [active]
575540001862	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
575540001863	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
575540001864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540001865	S-adenosylmethionine binding site [chemical binding]; other site
575540001866	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
575540001867	glyoxylate reductase; Reviewed; Region: PRK13243
575540001868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001869	homoserine dehydrogenase; Provisional; Region: PRK06349
575540001870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001871	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
575540001872	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
575540001873	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540001874	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
575540001875	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
575540001876	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
575540001877	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
575540001878	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
575540001879	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540001880	motif 1; other site
575540001881	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
575540001882	active site
575540001883	motif 2; other site
575540001884	motif 3; other site
575540001885	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
575540001886	anticodon binding site; other site
575540001887	Response regulator receiver domain; Region: Response_reg; pfam00072
575540001888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540001889	active site
575540001890	phosphorylation site [posttranslational modification]
575540001891	intermolecular recognition site; other site
575540001892	dimerization interface [polypeptide binding]; other site
575540001893	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
575540001894	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
575540001895	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
575540001896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540001897	ATP binding site [chemical binding]; other site
575540001898	Mg2+ binding site [ion binding]; other site
575540001899	G-X-G motif; other site
575540001900	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540001901	anti sigma factor interaction site; other site
575540001902	regulatory phosphorylation site [posttranslational modification]; other site
575540001903	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540001904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001905	Walker A motif; other site
575540001906	ATP binding site [chemical binding]; other site
575540001907	Walker B motif; other site
575540001908	arginine finger; other site
575540001909	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
575540001910	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540001911	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
575540001912	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
575540001913	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
575540001914	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540001915	ATP-dependent helicase; Provisional; Region: PRK13767
575540001916	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540001917	ATP binding site [chemical binding]; other site
575540001918	putative Mg++ binding site [ion binding]; other site
575540001919	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540001920	nucleotide binding region [chemical binding]; other site
575540001921	ATP-binding site [chemical binding]; other site
575540001922	DEAD/H associated; Region: DEAD_assoc; pfam08494
575540001923	sulfite oxidase; Provisional; Region: PLN00177
575540001924	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
575540001925	Moco binding site; other site
575540001926	metal coordination site [ion binding]; other site
575540001927	dimerization interface [polypeptide binding]; other site
575540001928	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540001929	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
575540001930	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
575540001931	catalytic residues [active]
575540001932	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540001933	Nitrogen regulatory protein P-II; Region: P-II; cl00412
575540001934	Nitrogen regulatory protein P-II; Region: P-II; smart00938
575540001935	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
575540001936	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
575540001937	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
575540001938	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
575540001939	putative active site [active]
575540001940	putative catalytic triad [active]
575540001941	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
575540001942	catalytic residues [active]
575540001943	Bacterial Ig-like domain; Region: Big_5; cl01012
575540001944	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
575540001945	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
575540001946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540001947	motif II; other site
575540001948	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
575540001949	Clp amino terminal domain; Region: Clp_N; pfam02861
575540001950	Clp amino terminal domain; Region: Clp_N; pfam02861
575540001951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001952	Walker A motif; other site
575540001953	ATP binding site [chemical binding]; other site
575540001954	Walker B motif; other site
575540001955	arginine finger; other site
575540001956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540001957	Walker A motif; other site
575540001958	ATP binding site [chemical binding]; other site
575540001959	Walker B motif; other site
575540001960	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
575540001961	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
575540001962	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
575540001963	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
575540001964	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540001965	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001966	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540001967	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
575540001968	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
575540001969	Helix-turn-helix domains; Region: HTH; cl00088
575540001970	Chorismate mutase type II; Region: CM_2; cl00693
575540001971	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
575540001972	Prephenate dehydratase; Region: PDT; pfam00800
575540001973	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
575540001974	putative L-Phe binding site [chemical binding]; other site
575540001975	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540001976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540001977	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540001978	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540001979	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540001980	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540001981	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540001982	active site
575540001983	ATP binding site [chemical binding]; other site
575540001984	substrate binding site [chemical binding]; other site
575540001985	activation loop (A-loop); other site
575540001986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
575540001987	active site
575540001988	phosphorylation site [posttranslational modification]
575540001989	intermolecular recognition site; other site
575540001990	dimerization interface [polypeptide binding]; other site
575540001991	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
575540001992	RNA/DNA binding site [nucleotide binding]; other site
575540001993	RRM dimerization site [polypeptide binding]; other site
575540001994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540001995	TPR motif; other site
575540001996	binding surface
575540001997	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540001998	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
575540001999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002000	photolyase PhrII; Region: phr2; TIGR00591
575540002001	DNA photolyase; Region: DNA_photolyase; pfam00875
575540002002	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
575540002003	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540002004	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540002005	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540002006	active site
575540002007	ATP binding site [chemical binding]; other site
575540002008	substrate binding site [chemical binding]; other site
575540002009	activation loop (A-loop); other site
575540002010	NMT1-like family; Region: NMT1_2; cl15260
575540002011	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
575540002012	GTP-binding protein LepA; Provisional; Region: PRK05433
575540002013	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
575540002014	G1 box; other site
575540002015	putative GEF interaction site [polypeptide binding]; other site
575540002016	GTP/Mg2+ binding site [chemical binding]; other site
575540002017	Switch I region; other site
575540002018	G2 box; other site
575540002019	G3 box; other site
575540002020	Switch II region; other site
575540002021	G4 box; other site
575540002022	G5 box; other site
575540002023	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
575540002024	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
575540002025	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
575540002026	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
575540002027	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540002028	Catalytic site [active]
575540002029	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540002030	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
575540002031	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540002032	Catalytic site [active]
575540002033	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540002034	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
575540002035	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
575540002036	Walker A/P-loop; other site
575540002037	ATP binding site [chemical binding]; other site
575540002038	Q-loop/lid; other site
575540002039	ABC transporter signature motif; other site
575540002040	Walker B; other site
575540002041	D-loop; other site
575540002042	H-loop/switch region; other site
575540002043	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540002044	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540002045	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
575540002046	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
575540002047	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
575540002048	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
575540002049	active site
575540002050	catalytic residues [active]
575540002051	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540002052	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
575540002053	endonuclease III; Region: ENDO3c; smart00478
575540002054	minor groove reading motif; other site
575540002055	helix-hairpin-helix signature motif; other site
575540002056	substrate binding pocket [chemical binding]; other site
575540002057	active site
575540002058	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
575540002059	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
575540002060	catalytic site [active]
575540002061	metal binding site [ion binding]; metal-binding site
575540002062	Oligomerisation domain; Region: Oligomerisation; cl00519
575540002063	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
575540002064	arginine-tRNA ligase; Region: PLN02286
575540002065	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
575540002066	active site
575540002067	HIGH motif; other site
575540002068	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
575540002069	KMSK motif region; other site
575540002070	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
575540002071	tRNA binding surface [nucleotide binding]; other site
575540002072	anticodon binding site; other site
575540002073	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
575540002074	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
575540002075	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
575540002076	Cytochrome c; Region: Cytochrom_C; cl11414
575540002077	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540002078	phosphopeptide binding site; other site
575540002079	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
575540002080	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
575540002081	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
575540002082	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
575540002083	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
575540002084	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
575540002085	active site
575540002086	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540002087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002088	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
575540002089	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
575540002090	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
575540002091	catalytic motif [active]
575540002092	Zn binding site [ion binding]; other site
575540002093	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
575540002094	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540002095	HEAT repeats; Region: HEAT_2; pfam13646
575540002096	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
575540002097	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540002098	Cytochrome c; Region: Cytochrom_C; cl11414
575540002099	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
575540002100	intersubunit interface [polypeptide binding]; other site
575540002101	active site
575540002102	catalytic residue [active]
575540002103	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540002104	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
575540002105	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540002106	Gas vesicle protein; Region: Gas_vesicle; cl02954
575540002107	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
575540002108	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
575540002109	Zn binding sites [ion binding]; other site
575540002110	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
575540002111	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
575540002112	Zn binding sites [ion binding]; other site
575540002113	Gas vesicle protein K; Region: GvpK; pfam05121
575540002114	Gas vesicle protein; Region: Gas_vesicle; cl02954
575540002115	Gas vesicle protein G; Region: GvpG; pfam05120
575540002116	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
575540002117	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
575540002118	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002119	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
575540002120	Gas vesicle protein; Region: Gas_vesicle; cl02954
575540002121	short chain dehydrogenase; Provisional; Region: PRK06197
575540002122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002123	NAD(P) binding site [chemical binding]; other site
575540002124	active site
575540002125	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540002126	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540002127	catalytic residue [active]
575540002128	Uncharacterized conserved protein [Function unknown]; Region: COG3391
575540002129	Phosphoesterase family; Region: Phosphoesterase; cl15450
575540002130	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540002131	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
575540002132	Cytochrome c; Region: Cytochrom_C; cl11414
575540002133	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
575540002134	Polysulphide reductase, NrfD; Region: NrfD; cl01295
575540002135	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
575540002136	molybdopterin cofactor binding site; other site
575540002137	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
575540002138	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
575540002139	4Fe-4S binding domain; Region: Fer4; cl02805
575540002140	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
575540002141	heme-binding residues [chemical binding]; other site
575540002142	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540002143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002144	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540002145	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
575540002146	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
575540002147	active site
575540002148	HIGH motif; other site
575540002149	dimer interface [polypeptide binding]; other site
575540002150	KMSKS motif; other site
575540002151	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
575540002152	RNA binding surface [nucleotide binding]; other site
575540002153	CAAX protease self-immunity; Region: Abi; cl00558
575540002154	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540002155	active site
575540002156	ATP binding site [chemical binding]; other site
575540002157	substrate binding site [chemical binding]; other site
575540002158	activation loop (A-loop); other site
575540002159	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002160	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540002161	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540002162	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540002163	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002164	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002165	G1 box; other site
575540002166	G1 box; other site
575540002167	GTP/Mg2+ binding site [chemical binding]; other site
575540002168	GTP/Mg2+ binding site [chemical binding]; other site
575540002169	G2 box; other site
575540002170	Switch I region; other site
575540002171	Switch I region; other site
575540002172	G2 box; other site
575540002173	G3 box; other site
575540002174	G3 box; other site
575540002175	Switch II region; other site
575540002176	Switch II region; other site
575540002177	G4 box; other site
575540002178	G5 box; other site
575540002179	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
575540002180	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
575540002181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540002182	Helix-turn-helix domains; Region: HTH; cl00088
575540002183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
575540002184	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
575540002185	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
575540002186	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540002187	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
575540002188	Cysteine-rich domain; Region: CCG; pfam02754
575540002189	Cysteine-rich domain; Region: CCG; pfam02754
575540002190	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
575540002191	FAD binding domain; Region: FAD_binding_4; pfam01565
575540002192	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
575540002193	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002194	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540002195	phosphopeptide binding site; other site
575540002196	GAF domain; Region: GAF; cl15785
575540002197	GAF domain; Region: GAF_2; pfam13185
575540002198	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
575540002199	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002200	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
575540002201	active site 2 [active]
575540002202	active site 1 [active]
575540002203	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
575540002204	tartrate dehydrogenase; Provisional; Region: PRK08194
575540002205	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
575540002206	nucleoside/Zn binding site; other site
575540002207	dimer interface [polypeptide binding]; other site
575540002208	catalytic motif [active]
575540002209	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
575540002210	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540002211	motif II; other site
575540002212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002213	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540002214	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
575540002215	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540002216	catalytic residue [active]
575540002217	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
575540002218	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540002219	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540002220	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540002221	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540002222	phosphoethanolamine N-methyltransferase; Region: PLN02336
575540002223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540002224	S-adenosylmethionine binding site [chemical binding]; other site
575540002225	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
575540002226	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540002227	active site
575540002228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540002229	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540002230	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002231	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
575540002232	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
575540002233	dimer interface [polypeptide binding]; other site
575540002234	active site
575540002235	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
575540002236	Ion transport protein; Region: Ion_trans; pfam00520
575540002237	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
575540002238	PHP-associated; Region: PHP_C; pfam13263
575540002239	Rhomboid family; Region: Rhomboid; cl11446
575540002240	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
575540002241	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
575540002242	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002243	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
575540002244	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
575540002245	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
575540002246	ATP-sulfurylase; Region: ATPS; cd00517
575540002247	active site
575540002248	HXXH motif; other site
575540002249	flexible loop; other site
575540002250	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
575540002251	ligand-binding site [chemical binding]; other site
575540002252	Predicted transcriptional regulator [Transcription]; Region: COG1959
575540002253	Helix-turn-helix domains; Region: HTH; cl00088
575540002254	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
575540002255	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
575540002256	Active Sites [active]
575540002257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
575540002258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540002259	ATP binding site [chemical binding]; other site
575540002260	Mg2+ binding site [ion binding]; other site
575540002261	G-X-G motif; other site
575540002262	aconitate hydratase; Validated; Region: PRK09277
575540002263	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
575540002264	substrate binding site [chemical binding]; other site
575540002265	ligand binding site [chemical binding]; other site
575540002266	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
575540002267	substrate binding site [chemical binding]; other site
575540002268	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
575540002269	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
575540002270	tetramer interface [polypeptide binding]; other site
575540002271	TPP-binding site [chemical binding]; other site
575540002272	heterodimer interface [polypeptide binding]; other site
575540002273	phosphorylation loop region [posttranslational modification]
575540002274	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
575540002275	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
575540002276	alpha subunit interface [polypeptide binding]; other site
575540002277	TPP binding site [chemical binding]; other site
575540002278	heterodimer interface [polypeptide binding]; other site
575540002279	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
575540002280	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
575540002281	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
575540002282	E3 interaction surface; other site
575540002283	lipoyl attachment site [posttranslational modification]; other site
575540002284	e3 binding domain; Region: E3_binding; pfam02817
575540002285	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
575540002286	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
575540002287	Colicin V production protein; Region: Colicin_V; cl00567
575540002288	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
575540002289	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540002290	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540002291	anti sigma factor interaction site; other site
575540002292	regulatory phosphorylation site [posttranslational modification]; other site
575540002293	Rhomboid family; Region: Rhomboid; cl11446
575540002294	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
575540002295	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
575540002296	Coenzyme A binding pocket [chemical binding]; other site
575540002297	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
575540002298	active site
575540002299	metal binding site [ion binding]; metal-binding site
575540002300	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
575540002301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540002302	S-adenosylmethionine binding site [chemical binding]; other site
575540002303	large tegument protein UL36; Provisional; Region: PHA03247
575540002304	Cytochrome c; Region: Cytochrom_C; cl11414
575540002305	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540002306	structural tetrad; other site
575540002307	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
575540002308	Low-spin heme binding site [chemical binding]; other site
575540002309	D-pathway; other site
575540002310	Putative water exit pathway; other site
575540002311	Binuclear center (active site) [active]
575540002312	K-pathway; other site
575540002313	Putative proton exit pathway; other site
575540002314	Cytochrome c; Region: Cytochrom_C; cl11414
575540002315	Cytochrome c; Region: Cytochrom_C; cl11414
575540002316	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
575540002317	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
575540002318	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
575540002319	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
575540002320	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
575540002321	D-pathway; other site
575540002322	Low-spin heme binding site [chemical binding]; other site
575540002323	Putative water exit pathway; other site
575540002324	Binuclear center (active site) [active]
575540002325	K-pathway; other site
575540002326	Putative proton exit pathway; other site
575540002327	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
575540002328	UbiA prenyltransferase family; Region: UbiA; cl00337
575540002329	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
575540002330	Subunit I/III interface [polypeptide binding]; other site
575540002331	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
575540002332	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
575540002333	inhibitor-cofactor binding pocket; inhibition site
575540002334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540002335	catalytic residue [active]
575540002336	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002337	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002338	TIGR03032 family protein; Region: TIGR03032
575540002339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002340	TPR motif; other site
575540002341	TPR repeat; Region: TPR_11; pfam13414
575540002342	binding surface
575540002343	TPR repeat; Region: TPR_11; pfam13414
575540002344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002345	binding surface
575540002346	TPR motif; other site
575540002347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002348	binding surface
575540002349	TPR motif; other site
575540002350	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
575540002351	ThiC family; Region: ThiC; cl08031
575540002352	putative efflux protein, MATE family; Region: matE; TIGR00797
575540002353	MatE; Region: MatE; cl10513
575540002354	MatE; Region: MatE; cl10513
575540002355	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
575540002356	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
575540002357	tetramerization interface [polypeptide binding]; other site
575540002358	active site
575540002359	Pantoate-beta-alanine ligase; Region: PanC; cd00560
575540002360	pantoate--beta-alanine ligase; Region: panC; TIGR00018
575540002361	active site
575540002362	ATP-binding site [chemical binding]; other site
575540002363	pantoate-binding site; other site
575540002364	HXXH motif; other site
575540002365	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
575540002366	dimer interface [polypeptide binding]; other site
575540002367	[2Fe-2S] cluster binding site [ion binding]; other site
575540002368	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
575540002369	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
575540002370	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
575540002371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002372	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540002373	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540002374	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
575540002375	Walker A/P-loop; other site
575540002376	ATP binding site [chemical binding]; other site
575540002377	Q-loop/lid; other site
575540002378	ABC transporter signature motif; other site
575540002379	Walker B; other site
575540002380	D-loop; other site
575540002381	H-loop/switch region; other site
575540002382	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
575540002383	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540002384	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
575540002385	BON domain; Region: BON; cl02771
575540002386	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540002387	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540002388	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540002389	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540002390	active site
575540002391	ATP binding site [chemical binding]; other site
575540002392	substrate binding site [chemical binding]; other site
575540002393	activation loop (A-loop); other site
575540002394	Predicted membrane protein [Function unknown]; Region: COG3463
575540002395	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
575540002396	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
575540002397	His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981
575540002398	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540002399	phosphopeptide binding site; other site
575540002400	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
575540002401	metal binding site [ion binding]; metal-binding site
575540002402	active site
575540002403	I-site; other site
575540002404	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540002405	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540002406	dimerization interface [polypeptide binding]; other site
575540002407	putative DNA binding site [nucleotide binding]; other site
575540002408	putative Zn2+ binding site [ion binding]; other site
575540002409	Chlorite dismutase; Region: Chlor_dismutase; cl01280
575540002410	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
575540002411	E3 interaction surface; other site
575540002412	lipoyl attachment site [posttranslational modification]; other site
575540002413	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
575540002414	active site
575540002415	Ap4A binding cleft/pocket [chemical binding]; other site
575540002416	P4 phosphate binding site; other site
575540002417	nudix motif; other site
575540002418	putative P2/P3 phosphate binding site [ion binding]; other site
575540002419	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
575540002420	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
575540002421	TMP-binding site; other site
575540002422	ATP-binding site [chemical binding]; other site
575540002423	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002424	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
575540002425	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002426	Oxygen tolerance; Region: BatD; pfam13584
575540002427	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
575540002428	Tetramer interface [polypeptide binding]; other site
575540002429	active site
575540002430	FMN-binding site [chemical binding]; other site
575540002431	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
575540002432	active site
575540002433	ATP binding site [chemical binding]; other site
575540002434	substrate binding site [chemical binding]; other site
575540002435	GAF domain; Region: GAF_2; pfam13185
575540002436	GAF domain; Region: GAF; cl15785
575540002437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540002438	dimer interface [polypeptide binding]; other site
575540002439	phosphorylation site [posttranslational modification]
575540002440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540002441	ATP binding site [chemical binding]; other site
575540002442	Mg2+ binding site [ion binding]; other site
575540002443	G-X-G motif; other site
575540002444	Response regulator receiver domain; Region: Response_reg; pfam00072
575540002445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540002446	active site
575540002447	phosphorylation site [posttranslational modification]
575540002448	intermolecular recognition site; other site
575540002449	dimerization interface [polypeptide binding]; other site
575540002450	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
575540002451	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540002452	extended (e) SDRs; Region: SDR_e; cd08946
575540002453	NAD(P) binding site [chemical binding]; other site
575540002454	active site
575540002455	substrate binding site [chemical binding]; other site
575540002456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002458	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
575540002459	NAD(P) binding site [chemical binding]; other site
575540002460	active site
575540002461	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
575540002462	putative glycosyl transferase; Provisional; Region: PRK10307
575540002463	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
575540002464	PA14 domain; Region: PA14; cl08459
575540002465	Cytochrome c; Region: Cytochrom_C; cl11414
575540002466	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540002467	Bacterial sugar transferase; Region: Bac_transf; cl00939
575540002468	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
575540002469	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540002470	active site
575540002471	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
575540002472	metal ion-dependent adhesion site (MIDAS); other site
575540002473	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
575540002474	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002475	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
575540002476	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
575540002477	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
575540002478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540002479	motif II; other site
575540002480	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
575540002481	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540002482	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540002483	catalytic residue [active]
575540002484	acetolactate synthase; Region: PLN02470
575540002485	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
575540002486	PYR/PP interface [polypeptide binding]; other site
575540002487	dimer interface [polypeptide binding]; other site
575540002488	TPP binding site [chemical binding]; other site
575540002489	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
575540002490	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
575540002491	TPP-binding site [chemical binding]; other site
575540002492	dimer interface [polypeptide binding]; other site
575540002493	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540002494	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540002495	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540002496	DNA binding residues [nucleotide binding]
575540002497	AF-4 proto-oncoprotein; Region: AF-4; pfam05110
575540002498	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
575540002499	trmE is a tRNA modification GTPase; Region: trmE; cd04164
575540002500	G1 box; other site
575540002501	GTP/Mg2+ binding site [chemical binding]; other site
575540002502	Switch I region; other site
575540002503	G2 box; other site
575540002504	Switch II region; other site
575540002505	G3 box; other site
575540002506	G4 box; other site
575540002507	G5 box; other site
575540002508	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
575540002509	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
575540002510	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
575540002511	putative active site [active]
575540002512	metal binding site [ion binding]; metal-binding site
575540002513	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540002514	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
575540002515	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540002516	catalytic residue [active]
575540002517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002518	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002519	PAS domain; Region: PAS_9; pfam13426
575540002520	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
575540002521	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540002522	dimer interface [polypeptide binding]; other site
575540002523	phosphorylation site [posttranslational modification]
575540002524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540002525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540002526	ATP binding site [chemical binding]; other site
575540002527	G-X-G motif; other site
575540002528	Response regulator receiver domain; Region: Response_reg; pfam00072
575540002529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540002530	active site
575540002531	phosphorylation site [posttranslational modification]
575540002532	intermolecular recognition site; other site
575540002533	dimerization interface [polypeptide binding]; other site
575540002534	Family description; Region: VCBS; pfam13517
575540002535	Family description; Region: VCBS; pfam13517
575540002536	Family description; Region: VCBS; pfam13517
575540002537	Family description; Region: VCBS; pfam13517
575540002538	Family description; Region: VCBS; pfam13517
575540002539	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540002540	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540002541	dimer interface [polypeptide binding]; other site
575540002542	active site
575540002543	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
575540002544	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
575540002545	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
575540002546	Bacitracin resistance protein BacA; Region: BacA; cl00858
575540002547	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
575540002548	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
575540002549	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
575540002550	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002551	Family description; Region: UvrD_C_2; cl15862
575540002552	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
575540002553	putative active site [active]
575540002554	catalytic triad [active]
575540002555	tartrate dehydrogenase; Provisional; Region: PRK08194
575540002556	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
575540002557	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540002558	Uncharacterized conserved protein [Function unknown]; Region: COG2006
575540002559	Domain of unknown function (DUF362); Region: DUF362; pfam04015
575540002560	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540002561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002562	TPR motif; other site
575540002563	binding surface
575540002564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002565	binding surface
575540002566	TPR motif; other site
575540002567	PEP-CTERM motif; Region: VPEP; cl15443
575540002568	Clp protease ATP binding subunit; Region: clpC; CHL00095
575540002569	Clp amino terminal domain; Region: Clp_N; pfam02861
575540002570	Clp amino terminal domain; Region: Clp_N; pfam02861
575540002571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540002572	Walker A motif; other site
575540002573	ATP binding site [chemical binding]; other site
575540002574	Walker B motif; other site
575540002575	arginine finger; other site
575540002576	UvrB/uvrC motif; Region: UVR; pfam02151
575540002577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540002578	Walker A motif; other site
575540002579	ATP binding site [chemical binding]; other site
575540002580	Walker B motif; other site
575540002581	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
575540002582	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540002583	active site
575540002584	ATP binding site [chemical binding]; other site
575540002585	substrate binding site [chemical binding]; other site
575540002586	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002587	substrate binding site [chemical binding]; other site
575540002588	activation loop (A-loop); other site
575540002589	activation loop (A-loop); other site
575540002590	Pectinesterase; Region: Pectinesterase; cl01911
575540002591	Right handed beta helix region; Region: Beta_helix; pfam13229
575540002592	Right handed beta helix region; Region: Beta_helix; pfam13229
575540002593	Right handed beta helix region; Region: Beta_helix; pfam13229
575540002594	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
575540002595	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
575540002596	NAD binding site [chemical binding]; other site
575540002597	substrate binding site [chemical binding]; other site
575540002598	active site
575540002599	potential frameshift: common BLAST hit: gi|32474083|ref|NP_867077.1| signal peptide
575540002600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
575540002601	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
575540002602	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
575540002603	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
575540002604	catalytic residue [active]
575540002605	putative FPP diphosphate  binding site; other site
575540002606	putative FPP binding hydrophobic cleft; other site
575540002607	dimer interface [polypeptide binding]; other site
575540002608	putative IPP diphosphate binding site; other site
575540002609	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
575540002610	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
575540002611	GDP-binding site [chemical binding]; other site
575540002612	ACT binding site; other site
575540002613	IMP binding site; other site
575540002614	PAS domain S-box; Region: sensory_box; TIGR00229
575540002615	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002616	PAS domain S-box; Region: sensory_box; TIGR00229
575540002617	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002618	PAS domain S-box; Region: sensory_box; TIGR00229
575540002619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002620	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
575540002621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540002622	active site
575540002623	phosphorylation site [posttranslational modification]
575540002624	intermolecular recognition site; other site
575540002625	dimerization interface [polypeptide binding]; other site
575540002626	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
575540002627	metal binding site [ion binding]; metal-binding site
575540002628	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
575540002629	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
575540002630	metal binding site [ion binding]; metal-binding site
575540002631	dimer interface [polypeptide binding]; other site
575540002632	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
575540002633	classical (c) SDRs; Region: SDR_c; cd05233
575540002634	NAD(P) binding site [chemical binding]; other site
575540002635	active site
575540002636	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
575540002637	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
575540002638	putative active site [active]
575540002639	putative catalytic triad [active]
575540002640	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
575540002641	catalytic residues [active]
575540002642	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
575540002643	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
575540002644	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
575540002645	putative active site [active]
575540002646	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
575540002647	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540002648	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540002649	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
575540002650	putative active site [active]
575540002651	putative metal binding site [ion binding]; other site
575540002652	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
575540002653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540002654	S-adenosylmethionine binding site [chemical binding]; other site
575540002655	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
575540002656	putative metal binding site; other site
575540002657	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
575540002658	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
575540002659	Probable Catalytic site; other site
575540002660	metal-binding site
575540002661	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
575540002662	phytoene desaturase; Region: crtI_fam; TIGR02734
575540002663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002664	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540002665	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540002666	active site
575540002667	Cadherin repeat-like domain; Region: CA_like; cl15786
575540002668	large tegument protein UL36; Provisional; Region: PHA03246
575540002669	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002670	active site
575540002671	ATP binding site [chemical binding]; other site
575540002672	substrate binding site [chemical binding]; other site
575540002673	activation loop (A-loop); other site
575540002674	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
575540002675	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540002676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002677	TPR motif; other site
575540002678	binding surface
575540002679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540002680	binding surface
575540002681	TPR motif; other site
575540002682	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540002683	Fibronectin type III-like domain; Region: Fn3-like; cl15273
575540002684	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540002685	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540002686	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540002687	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540002688	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002689	active site
575540002690	ATP binding site [chemical binding]; other site
575540002691	substrate binding site [chemical binding]; other site
575540002692	activation loop (A-loop); other site
575540002693	phosphodiesterase; Provisional; Region: PRK12704
575540002694	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
575540002695	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
575540002696	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540002697	TPR motif; other site
575540002698	binding surface
575540002699	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540002700	TPR motif; other site
575540002701	binding surface
575540002702	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
575540002703	putative active site [active]
575540002704	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
575540002705	putative acyl-acceptor binding pocket; other site
575540002706	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
575540002707	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
575540002708	active site
575540002709	dimer interface [polypeptide binding]; other site
575540002710	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
575540002711	Ligand Binding Site [chemical binding]; other site
575540002712	Molecular Tunnel; other site
575540002713	Protein of unknown function (DUF962); Region: DUF962; cl01879
575540002714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002715	TIGR01777 family protein; Region: yfcH
575540002716	NAD(P) binding site [chemical binding]; other site
575540002717	active site
575540002718	MAPEG family; Region: MAPEG; cl09190
575540002719	Helix-turn-helix domains; Region: HTH; cl00088
575540002720	Acetokinase family; Region: Acetate_kinase; cl01029
575540002721	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540002722	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
575540002723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002724	NAD(P) binding pocket [chemical binding]; other site
575540002725	Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774
575540002726	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
575540002727	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
575540002728	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002729	G1 box; other site
575540002730	GTP/Mg2+ binding site [chemical binding]; other site
575540002731	G2 box; other site
575540002732	Switch I region; other site
575540002733	G3 box; other site
575540002734	Switch II region; other site
575540002735	G4 box; other site
575540002736	G5 box; other site
575540002737	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
575540002738	EamA-like transporter family; Region: EamA; cl01037
575540002739	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
575540002740	EamA-like transporter family; Region: EamA; cl01037
575540002741	Permease; Region: Permease; cl00510
575540002742	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
575540002743	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
575540002744	active site
575540002745	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
575540002746	dimer interface [polypeptide binding]; other site
575540002747	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
575540002748	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
575540002749	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
575540002750	substrate binding site [chemical binding]; other site
575540002751	ATP binding site [chemical binding]; other site
575540002752	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
575540002753	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
575540002754	substrate binding site [chemical binding]; other site
575540002755	glutamase interaction surface [polypeptide binding]; other site
575540002756	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
575540002757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002758	Walker A motif; other site
575540002759	ATP binding site [chemical binding]; other site
575540002760	Walker B motif; other site
575540002761	Type II/IV secretion system protein; Region: T2SE; pfam00437
575540002762	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002763	Walker A motif; other site
575540002764	ATP binding site [chemical binding]; other site
575540002765	Walker B motif; other site
575540002766	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
575540002767	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
575540002768	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
575540002769	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
575540002770	catalytic site [active]
575540002771	active site
575540002772	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
575540002773	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
575540002774	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
575540002775	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
575540002776	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
575540002777	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
575540002778	active site
575540002779	catalytic site [active]
575540002780	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
575540002781	hypothetical protein; Reviewed; Region: PRK09588
575540002782	aspartate aminotransferase; Provisional; Region: PRK05764
575540002783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540002784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540002785	homodimer interface [polypeptide binding]; other site
575540002786	catalytic residue [active]
575540002787	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540002788	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540002789	active site
575540002790	ATP binding site [chemical binding]; other site
575540002791	substrate binding site [chemical binding]; other site
575540002792	activation loop (A-loop); other site
575540002793	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540002794	cyclase homology domain; Region: CHD; cd07302
575540002795	dimer interface [polypeptide binding]; other site
575540002796	nucleotidyl binding site; other site
575540002797	metal binding site [ion binding]; metal-binding site
575540002798	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
575540002799	Cell division protein FtsA; Region: FtsA; cl11496
575540002800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540002801	PAS domain; Region: PAS_9; pfam13426
575540002802	PAS domain S-box; Region: sensory_box; TIGR00229
575540002803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540002804	putative active site [active]
575540002805	heme pocket [chemical binding]; other site
575540002806	GAF domain; Region: GAF_2; pfam13185
575540002807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540002808	dimer interface [polypeptide binding]; other site
575540002809	phosphorylation site [posttranslational modification]
575540002810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540002811	ATP binding site [chemical binding]; other site
575540002812	Mg2+ binding site [ion binding]; other site
575540002813	G-X-G motif; other site
575540002814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
575540002815	active site
575540002816	phosphorylation site [posttranslational modification]
575540002817	intermolecular recognition site; other site
575540002818	dimerization interface [polypeptide binding]; other site
575540002819	Response regulator receiver domain; Region: Response_reg; pfam00072
575540002820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540002821	active site
575540002822	phosphorylation site [posttranslational modification]
575540002823	intermolecular recognition site; other site
575540002824	dimerization interface [polypeptide binding]; other site
575540002825	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
575540002826	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540002827	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
575540002828	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540002829	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540002830	Walker A/P-loop; other site
575540002831	ATP binding site [chemical binding]; other site
575540002832	Q-loop/lid; other site
575540002833	ABC transporter signature motif; other site
575540002834	Walker B; other site
575540002835	D-loop; other site
575540002836	H-loop/switch region; other site
575540002837	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
575540002838	putative acyl-acceptor binding pocket; other site
575540002839	CutC family; Region: CutC; cl01218
575540002840	Hsp70 protein; Region: HSP70; pfam00012
575540002841	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450
575540002842	integrin inhibitor binding pocket; other site
575540002843	metal ion-dependent adhesion site (MIDAS); other site
575540002844	integrin-collagen binding site; other site
575540002845	putative vWF-collagen binding site; other site
575540002846	glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site
575540002847	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
575540002848	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
575540002849	active site
575540002850	catalytic motif [active]
575540002851	Zn binding site [ion binding]; other site
575540002852	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
575540002853	AMP-binding enzyme; Region: AMP-binding; cl15778
575540002854	Cupin domain; Region: Cupin_2; cl09118
575540002855	Cytochrome c; Region: Cytochrom_C; cl11414
575540002856	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
575540002857	rRNA binding site [nucleotide binding]; other site
575540002858	predicted 30S ribosome binding site; other site
575540002859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002860	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
575540002861	NAD(P) binding site [chemical binding]; other site
575540002862	active site
575540002863	peptide synthase; Provisional; Region: PRK09274
575540002864	AMP-binding enzyme; Region: AMP-binding; cl15778
575540002865	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
575540002866	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
575540002867	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
575540002868	Walker A/P-loop; other site
575540002869	ATP binding site [chemical binding]; other site
575540002870	Q-loop/lid; other site
575540002871	ABC transporter signature motif; other site
575540002872	Walker B; other site
575540002873	D-loop; other site
575540002874	H-loop/switch region; other site
575540002875	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540002876	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
575540002877	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540002878	Maf-like protein; Region: Maf; pfam02545
575540002879	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
575540002880	active site
575540002881	dimer interface [polypeptide binding]; other site
575540002882	sulfite reductase subunit beta; Provisional; Region: PRK13504
575540002883	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
575540002884	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
575540002885	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
575540002886	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
575540002887	Potassium binding sites [ion binding]; other site
575540002888	Cesium cation binding sites [ion binding]; other site
575540002889	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
575540002890	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
575540002891	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
575540002892	G1 box; other site
575540002893	GTP/Mg2+ binding site [chemical binding]; other site
575540002894	G2 box; other site
575540002895	Switch I region; other site
575540002896	G3 box; other site
575540002897	Switch II region; other site
575540002898	G4 box; other site
575540002899	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
575540002900	G1 box; other site
575540002901	GTP/Mg2+ binding site [chemical binding]; other site
575540002902	G2 box; other site
575540002903	Switch I region; other site
575540002904	G3 box; other site
575540002905	Switch II region; other site
575540002906	Domain of unknown function (DUF697); Region: DUF697; cl12064
575540002907	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
575540002908	ABC-ATPase subunit  interface; other site
575540002909	dimer interface [polypeptide binding]; other site
575540002910	putative PBP binding regions; other site
575540002911	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
575540002912	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
575540002913	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
575540002914	ABC-ATPase subunit  interface; other site
575540002915	dimer interface [polypeptide binding]; other site
575540002916	putative PBP binding regions; other site
575540002917	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
575540002918	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
575540002919	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
575540002920	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
575540002921	intersubunit interface [polypeptide binding]; other site
575540002922	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
575540002923	active site
575540002924	NAD binding site [chemical binding]; other site
575540002925	metal binding site [ion binding]; metal-binding site
575540002926	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
575540002927	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
575540002928	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
575540002929	DEAD-like helicases superfamily; Region: DEXDc; smart00487
575540002930	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540002931	ATP binding site [chemical binding]; other site
575540002932	putative Mg++ binding site [ion binding]; other site
575540002933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540002934	nucleotide binding region [chemical binding]; other site
575540002935	ATP-binding site [chemical binding]; other site
575540002936	TRCF domain; Region: TRCF; cl04088
575540002937	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
575540002938	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
575540002939	active site
575540002940	Riboflavin kinase; Region: Flavokinase; cl03312
575540002941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002943	VanZ like family; Region: VanZ; cl01971
575540002944	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
575540002945	active site
575540002946	catalytic residues [active]
575540002947	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540002948	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540002949	Bacterial Ig-like domain; Region: Big_5; cl01012
575540002950	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
575540002951	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540002952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002953	ParB-like nuclease domain; Region: ParBc; cl02129
575540002954	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
575540002955	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
575540002956	active site
575540002957	ADP/pyrophosphate binding site [chemical binding]; other site
575540002958	dimerization interface [polypeptide binding]; other site
575540002959	allosteric effector site; other site
575540002960	fructose-1,6-bisphosphate binding site; other site
575540002961	TPR repeat; Region: TPR_11; pfam13414
575540002962	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540002963	protein binding site [polypeptide binding]; other site
575540002964	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
575540002965	Catalytic dyad [active]
575540002966	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540002967	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540002968	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540002969	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
575540002970	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
575540002971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002972	NAD(P) binding site [chemical binding]; other site
575540002973	active site
575540002974	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
575540002975	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540002976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540002977	homodimer interface [polypeptide binding]; other site
575540002978	catalytic residue [active]
575540002979	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792
575540002980	competence damage-inducible protein A; Provisional; Region: PRK00549
575540002981	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
575540002982	putative MPT binding site; other site
575540002983	Competence-damaged protein; Region: CinA; cl00666
575540002984	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
575540002985	active site
575540002986	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540002987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540002988	NAD(P) binding site [chemical binding]; other site
575540002989	active site
575540002990	DNA topoisomerase I; Validated; Region: PRK06599
575540002991	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
575540002992	active site
575540002993	interdomain interaction site; other site
575540002994	putative metal-binding site [ion binding]; other site
575540002995	nucleotide binding site [chemical binding]; other site
575540002996	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
575540002997	domain I; other site
575540002998	DNA binding groove [nucleotide binding]
575540002999	phosphate binding site [ion binding]; other site
575540003000	domain II; other site
575540003001	domain III; other site
575540003002	nucleotide binding site [chemical binding]; other site
575540003003	catalytic site [active]
575540003004	domain IV; other site
575540003005	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
575540003006	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
575540003007	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
575540003008	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
575540003009	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
575540003010	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
575540003011	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
575540003012	Fasciclin domain; Region: Fasciclin; cl02663
575540003013	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
575540003014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003015	NAD(P) binding site [chemical binding]; other site
575540003016	active site
575540003017	Deoxyhypusine synthase; Region: DS; cl00826
575540003018	CAAX protease self-immunity; Region: Abi; cl00558
575540003019	Uncharacterized conserved protein [Function unknown]; Region: COG3391
575540003020	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
575540003021	Phosphoesterase family; Region: Phosphoesterase; cl15450
575540003022	Phosphoesterase family; Region: Phosphoesterase; cl15450
575540003023	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540003024	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540003025	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540003026	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
575540003027	nuclear egress membrane protein UL34; Provisional; Region: PHA03324
575540003028	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
575540003029	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
575540003030	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
575540003031	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
575540003032	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
575540003033	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
575540003034	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
575540003035	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
575540003036	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
575540003037	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
575540003038	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540003039	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
575540003040	dimerization domain swap beta strand [polypeptide binding]; other site
575540003041	regulatory protein interface [polypeptide binding]; other site
575540003042	active site
575540003043	regulatory phosphorylation site [posttranslational modification]; other site
575540003044	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
575540003045	active site
575540003046	phosphorylation site [posttranslational modification]
575540003047	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540003048	active site
575540003049	catalytic residues [active]
575540003050	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
575540003051	chorismate binding enzyme; Region: Chorismate_bind; cl10555
575540003052	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
575540003053	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
575540003054	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
575540003055	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540003056	Sulfatase; Region: Sulfatase; cl10460
575540003057	Sulfatase; Region: Sulfatase; cl10460
575540003058	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540003059	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
575540003060	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
575540003061	AMP binding site [chemical binding]; other site
575540003062	metal binding site [ion binding]; metal-binding site
575540003063	active site
575540003064	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
575540003065	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
575540003066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003067	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
575540003068	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
575540003069	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
575540003070	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
575540003071	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540003072	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540003073	catalytic residue [active]
575540003074	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540003075	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
575540003076	active site
575540003077	biotin synthase; Region: bioB; TIGR00433
575540003078	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540003079	FeS/SAM binding site; other site
575540003080	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
575540003081	Flagellin N-methylase; Region: FliB; cl00497
575540003082	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
575540003083	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
575540003084	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
575540003085	active site
575540003086	putative substrate binding region [chemical binding]; other site
575540003087	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
575540003088	aromatic arch; other site
575540003089	DCoH dimer interaction site [polypeptide binding]; other site
575540003090	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
575540003091	DCoH tetramer interaction site [polypeptide binding]; other site
575540003092	substrate binding site [chemical binding]; other site
575540003093	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
575540003094	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
575540003095	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
575540003096	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
575540003097	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
575540003098	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
575540003099	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540003100	NAD-dependent deacetylase; Provisional; Region: PRK00481
575540003101	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
575540003102	NAD+ binding site [chemical binding]; other site
575540003103	substrate binding site [chemical binding]; other site
575540003104	Zn binding site [ion binding]; other site
575540003105	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540003106	argininosuccinate lyase; Provisional; Region: PRK00855
575540003107	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
575540003108	active sites [active]
575540003109	tetramer interface [polypeptide binding]; other site
575540003110	diaminopimelate decarboxylase; Region: lysA; TIGR01048
575540003111	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
575540003112	active site
575540003113	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
575540003114	substrate binding site [chemical binding]; other site
575540003115	catalytic residues [active]
575540003116	dimer interface [polypeptide binding]; other site
575540003117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540003118	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
575540003119	Walker A motif; other site
575540003120	ATP binding site [chemical binding]; other site
575540003121	Walker B motif; other site
575540003122	arginine finger; other site
575540003123	Helix-turn-helix domains; Region: HTH; cl00088
575540003124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540003125	putative substrate translocation pore; other site
575540003126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
575540003127	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
575540003128	Ligand binding site; other site
575540003129	Putative Catalytic site; other site
575540003130	DXD motif; other site
575540003131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
575540003132	non-specific DNA binding site [nucleotide binding]; other site
575540003133	salt bridge; other site
575540003134	sequence-specific DNA binding site [nucleotide binding]; other site
575540003135	Cupin domain; Region: Cupin_2; cl09118
575540003136	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
575540003137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003138	NAD(P) binding site [chemical binding]; other site
575540003139	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
575540003140	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
575540003141	substrate-cofactor binding pocket; other site
575540003142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540003143	catalytic residue [active]
575540003144	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003146	active site
575540003147	phosphorylation site [posttranslational modification]
575540003148	intermolecular recognition site; other site
575540003149	dimerization interface [polypeptide binding]; other site
575540003150	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
575540003151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540003152	dimer interface [polypeptide binding]; other site
575540003153	phosphorylation site [posttranslational modification]
575540003154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540003155	ATP binding site [chemical binding]; other site
575540003156	Mg2+ binding site [ion binding]; other site
575540003157	G-X-G motif; other site
575540003158	PAS fold; Region: PAS_2; pfam08446
575540003159	GAF domain; Region: GAF; cl15785
575540003160	Phytochrome region; Region: PHY; pfam00360
575540003161	PAS fold; Region: PAS; pfam00989
575540003162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540003163	putative active site [active]
575540003164	heme pocket [chemical binding]; other site
575540003165	PAS fold; Region: PAS_3; pfam08447
575540003166	PAS domain S-box; Region: sensory_box; TIGR00229
575540003167	hypothetical protein; Provisional; Region: PRK13560
575540003168	Histidine kinase; Region: HisKA_2; cl06527
575540003169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540003170	ATP binding site [chemical binding]; other site
575540003171	Mg2+ binding site [ion binding]; other site
575540003172	G-X-G motif; other site
575540003173	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540003174	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003175	Walker A/P-loop; other site
575540003176	ATP binding site [chemical binding]; other site
575540003177	Q-loop/lid; other site
575540003178	ABC transporter signature motif; other site
575540003179	Walker B; other site
575540003180	D-loop; other site
575540003181	H-loop/switch region; other site
575540003182	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540003183	Cytochrome c; Region: Cytochrom_C; cl11414
575540003184	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540003185	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540003186	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540003187	Methyltransferase domain; Region: Methyltransf_31; pfam13847
575540003188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540003189	S-adenosylmethionine binding site [chemical binding]; other site
575540003190	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540003191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003192	binding surface
575540003193	TPR motif; other site
575540003194	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540003195	TPR repeat; Region: TPR_11; pfam13414
575540003196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003197	binding surface
575540003198	TPR motif; other site
575540003199	TPR repeat; Region: TPR_11; pfam13414
575540003200	TPR repeat; Region: TPR_11; pfam13414
575540003201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003202	binding surface
575540003203	TPR motif; other site
575540003204	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540003205	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
575540003206	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
575540003207	nucleotide binding pocket [chemical binding]; other site
575540003208	K-X-D-G motif; other site
575540003209	catalytic site [active]
575540003210	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
575540003211	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
575540003212	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
575540003213	putative ADP-binding pocket [chemical binding]; other site
575540003214	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540003215	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
575540003216	putative ADP-binding pocket [chemical binding]; other site
575540003217	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
575540003218	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
575540003219	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
575540003220	active site
575540003221	homodimer interface [polypeptide binding]; other site
575540003222	catalytic site [active]
575540003223	acceptor binding site [chemical binding]; other site
575540003224	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
575540003225	NMT1-like family; Region: NMT1_2; cl15260
575540003226	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
575540003227	Dienelactone hydrolase family; Region: DLH; pfam01738
575540003228	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003229	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
575540003230	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
575540003231	substrate binding site [chemical binding]; other site
575540003232	oxyanion hole (OAH) forming residues; other site
575540003233	trimer interface [polypeptide binding]; other site
575540003234	DsrE/DsrF-like family; Region: DrsE; cl00672
575540003235	transketolase; Reviewed; Region: PRK05899
575540003236	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
575540003237	TPP-binding site [chemical binding]; other site
575540003238	dimer interface [polypeptide binding]; other site
575540003239	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
575540003240	PYR/PP interface [polypeptide binding]; other site
575540003241	dimer interface [polypeptide binding]; other site
575540003242	TPP binding site [chemical binding]; other site
575540003243	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
575540003244	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003245	active site
575540003246	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
575540003247	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
575540003248	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
575540003249	homodimer interface [polypeptide binding]; other site
575540003250	substrate-cofactor binding pocket; other site
575540003251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540003252	catalytic residue [active]
575540003253	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
575540003254	Outer membrane efflux protein; Region: OEP; pfam02321
575540003255	Outer membrane efflux protein; Region: OEP; pfam02321
575540003256	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
575540003257	Domain of unknown function DUF21; Region: DUF21; pfam01595
575540003258	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
575540003259	Transporter associated domain; Region: CorC_HlyC; cl08393
575540003260	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540003261	phosphopeptide binding site; other site
575540003262	ribosomal protein S1; Region: rpsA; TIGR00717
575540003263	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
575540003264	RNA binding site [nucleotide binding]; other site
575540003265	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
575540003266	RNA binding site [nucleotide binding]; other site
575540003267	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
575540003268	RNA binding site [nucleotide binding]; other site
575540003269	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
575540003270	RNA binding site [nucleotide binding]; other site
575540003271	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
575540003272	RNA binding site [nucleotide binding]; other site
575540003273	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
575540003274	RNA binding site [nucleotide binding]; other site
575540003275	Methyltransferase domain; Region: Methyltransf_31; pfam13847
575540003276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540003277	S-adenosylmethionine binding site [chemical binding]; other site
575540003278	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
575540003279	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
575540003280	S17 interaction site [polypeptide binding]; other site
575540003281	S8 interaction site; other site
575540003282	16S rRNA interaction site [nucleotide binding]; other site
575540003283	streptomycin interaction site [chemical binding]; other site
575540003284	23S rRNA interaction site [nucleotide binding]; other site
575540003285	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
575540003286	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
575540003287	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
575540003288	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540003289	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540003290	active site
575540003291	ATP binding site [chemical binding]; other site
575540003292	substrate binding site [chemical binding]; other site
575540003293	activation loop (A-loop); other site
575540003294	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
575540003295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003296	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
575540003297	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540003298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003299	binding surface
575540003300	TPR motif; other site
575540003301	Family description; Region: VCBS; pfam13517
575540003302	Family description; Region: VCBS; pfam13517
575540003303	Family description; Region: VCBS; pfam13517
575540003304	Family description; Region: VCBS; pfam13517
575540003305	Family description; Region: VCBS; pfam13517
575540003306	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
575540003307	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540003308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003309	active site
575540003310	phosphorylation site [posttranslational modification]
575540003311	intermolecular recognition site; other site
575540003312	dimerization interface [polypeptide binding]; other site
575540003313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540003314	Walker A motif; other site
575540003315	ATP binding site [chemical binding]; other site
575540003316	Walker B motif; other site
575540003317	arginine finger; other site
575540003318	Helix-turn-helix domains; Region: HTH; cl00088
575540003319	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
575540003320	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
575540003321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540003322	phosphorylation site [posttranslational modification]
575540003323	dimer interface [polypeptide binding]; other site
575540003324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540003325	ATP binding site [chemical binding]; other site
575540003326	Mg2+ binding site [ion binding]; other site
575540003327	G-X-G motif; other site
575540003328	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
575540003329	Paraquat-inducible protein A; Region: PqiA; pfam04403
575540003330	mce related protein; Region: MCE; pfam02470
575540003331	mce related protein; Region: MCE; pfam02470
575540003332	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
575540003333	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
575540003334	ligand binding site; other site
575540003335	oligomer interface; other site
575540003336	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
575540003337	dimer interface [polypeptide binding]; other site
575540003338	N-terminal domain interface [polypeptide binding]; other site
575540003339	sulfate 1 binding site; other site
575540003340	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003341	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540003342	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
575540003343	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540003344	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003345	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
575540003346	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
575540003347	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
575540003348	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003349	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003350	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003351	VPS10 domain; Region: VPS10; smart00602
575540003352	VPS10 domain; Region: VPS10; smart00602
575540003353	FlgD Ig-like domain; Region: FlgD_ig; cl15790
575540003354	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
575540003355	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003356	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
575540003357	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
575540003358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540003359	active site
575540003360	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540003361	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
575540003362	Cytochrome c; Region: Cytochrom_C; cl11414
575540003363	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540003364	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540003365	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540003366	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540003367	active site
575540003368	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540003369	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540003370	ferrochelatase; Reviewed; Region: hemH; PRK00035
575540003371	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
575540003372	C-terminal domain interface [polypeptide binding]; other site
575540003373	active site
575540003374	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
575540003375	active site
575540003376	N-terminal domain interface [polypeptide binding]; other site
575540003377	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
575540003378	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
575540003379	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540003380	active site
575540003381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540003382	Major Facilitator Superfamily; Region: MFS_1; pfam07690
575540003383	putative substrate translocation pore; other site
575540003384	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
575540003385	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
575540003386	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540003387	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540003388	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
575540003389	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540003390	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540003391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540003392	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
575540003393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540003394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003395	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
575540003396	dihydrodipicolinate synthase; Region: dapA; TIGR00674
575540003397	dimer interface [polypeptide binding]; other site
575540003398	active site
575540003399	catalytic residue [active]
575540003400	Sodium:solute symporter family; Region: SSF; cl00456
575540003401	TIR domain; Region: TIR_2; cl15770
575540003402	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540003403	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540003404	dimer interface [polypeptide binding]; other site
575540003405	active site
575540003406	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
575540003407	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
575540003408	dimer interface [polypeptide binding]; other site
575540003409	active site
575540003410	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540003411	selenocysteine synthase; Provisional; Region: PRK04311
575540003412	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540003413	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540003414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003415	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540003416	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540003417	DNA interaction; other site
575540003418	Metal-binding active site; metal-binding site
575540003419	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
575540003420	DNA gyrase subunit A; Validated; Region: PRK05560
575540003421	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
575540003422	CAP-like domain; other site
575540003423	active site
575540003424	primary dimer interface [polypeptide binding]; other site
575540003425	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003426	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003427	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003428	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003429	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003430	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540003431	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
575540003432	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540003433	Sulfatase; Region: Sulfatase; cl10460
575540003434	Amino acid permease; Region: AA_permease_2; pfam13520
575540003435	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
575540003436	Ligand Binding Site [chemical binding]; other site
575540003437	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540003438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003439	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540003440	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540003441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003442	binding surface
575540003443	TPR motif; other site
575540003444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003445	binding surface
575540003446	TPR motif; other site
575540003447	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540003448	active site
575540003449	ATP binding site [chemical binding]; other site
575540003450	substrate binding site [chemical binding]; other site
575540003451	activation loop (A-loop); other site
575540003452	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
575540003453	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
575540003454	dimer interface [polypeptide binding]; other site
575540003455	putative functional site; other site
575540003456	putative MPT binding site; other site
575540003457	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540003458	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
575540003459	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003460	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003461	active site
575540003462	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003463	active site
575540003464	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
575540003465	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003466	active site
575540003467	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
575540003468	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003469	active site
575540003470	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003471	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003472	active site
575540003473	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
575540003474	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003475	active site
575540003476	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
575540003477	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003478	active site
575540003479	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003480	MAEBL; Provisional; Region: PTZ00121
575540003481	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003482	active site
575540003483	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540003484	active site
575540003485	Methane oxygenase PmoA; Region: PmoA; pfam14100
575540003486	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
575540003487	DNA polymerase III, delta subunit; Region: holA; TIGR01128
575540003488	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
575540003489	cyclase homology domain; Region: CHD; cd07302
575540003490	nucleotidyl binding site; other site
575540003491	metal binding site [ion binding]; metal-binding site
575540003492	dimer interface [polypeptide binding]; other site
575540003493	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540003494	HEAT repeats; Region: HEAT_2; pfam13646
575540003495	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540003496	Cytochrome c; Region: Cytochrom_C; cl11414
575540003497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540003498	S-adenosylmethionine binding site [chemical binding]; other site
575540003499	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
575540003500	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
575540003501	active site
575540003502	NTP binding site [chemical binding]; other site
575540003503	metal binding triad [ion binding]; metal-binding site
575540003504	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
575540003505	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540003506	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
575540003507	Fe-S cluster binding site [ion binding]; other site
575540003508	active site
575540003509	TPR repeat; Region: TPR_11; pfam13414
575540003510	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
575540003511	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003512	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540003513	Sulfatase; Region: Sulfatase; cl10460
575540003514	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
575540003515	isocitrate dehydrogenase; Validated; Region: PRK06451
575540003516	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
575540003517	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
575540003518	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
575540003519	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
575540003520	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
575540003521	putative active site [active]
575540003522	glutamate dehydrogenase; Region: PLN02477
575540003523	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
575540003524	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
575540003525	NAD(P) binding site [chemical binding]; other site
575540003526	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
575540003527	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
575540003528	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
575540003529	Zn2+ binding site [ion binding]; other site
575540003530	Mg2+ binding site [ion binding]; other site
575540003531	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003532	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003534	active site
575540003535	phosphorylation site [posttranslational modification]
575540003536	intermolecular recognition site; other site
575540003537	dimerization interface [polypeptide binding]; other site
575540003538	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
575540003539	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
575540003540	NAD(P) binding site [chemical binding]; other site
575540003541	catalytic residues [active]
575540003542	Helix-turn-helix domains; Region: HTH; cl00088
575540003543	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
575540003544	active site
575540003545	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
575540003546	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
575540003547	active site
575540003548	octamer interface [polypeptide binding]; other site
575540003549	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540003550	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540003551	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540003552	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
575540003553	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
575540003554	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
575540003555	Ferritin-like domain; Region: Ferritin; pfam00210
575540003556	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
575540003557	dinuclear metal binding motif [ion binding]; other site
575540003558	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
575540003559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
575540003560	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540003561	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003562	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
575540003563	Y-family of DNA polymerases; Region: PolY; cl12025
575540003564	active site
575540003565	DNA binding site [nucleotide binding]
575540003566	impB/mucB/samB family C-terminal; Region: IMS_C; pfam11799
575540003567	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
575540003568	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
575540003569	Rhomboid family; Region: Rhomboid; cl11446
575540003570	RF-1 domain; Region: RF-1; cl02875
575540003571	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003572	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003573	Right handed beta helix region; Region: Beta_helix; pfam13229
575540003574	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003575	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003576	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003577	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540003578	Calx-beta domain; Region: Calx-beta; cl02522
575540003579	Calx-beta domain; Region: Calx-beta; cl02522
575540003580	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
575540003581	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
575540003582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
575540003583	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540003584	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
575540003585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003586	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
575540003587	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
575540003588	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
575540003589	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
575540003590	generic binding surface II; other site
575540003591	generic binding surface I; other site
575540003592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003593	AAA domain; Region: AAA_22; pfam13401
575540003594	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
575540003595	serine O-acetyltransferase; Region: cysE; TIGR01172
575540003596	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
575540003597	trimer interface [polypeptide binding]; other site
575540003598	active site
575540003599	substrate binding site [chemical binding]; other site
575540003600	CoA binding site [chemical binding]; other site
575540003601	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540003602	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540003603	Metal-binding active site; metal-binding site
575540003604	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
575540003605	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
575540003606	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540003607	catalytic core [active]
575540003608	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
575540003609	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
575540003610	putative acyl-acceptor binding pocket; other site
575540003611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540003612	S-adenosylmethionine binding site [chemical binding]; other site
575540003613	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
575540003614	Ubiquitin-like proteins; Region: UBQ; cl00155
575540003615	Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154
575540003616	E3 interaction residues; other site
575540003617	Ub thioester intermediate interaction residues; other site
575540003618	active site cysteine
575540003619	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
575540003620	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
575540003621	ATP binding site [chemical binding]; other site
575540003622	substrate interface [chemical binding]; other site
575540003623	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
575540003624	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
575540003625	Transport protein; Region: actII; TIGR00833
575540003626	Protein export membrane protein; Region: SecD_SecF; cl14618
575540003627	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
575540003628	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003629	Walker A/P-loop; other site
575540003630	ATP binding site [chemical binding]; other site
575540003631	Q-loop/lid; other site
575540003632	ABC transporter signature motif; other site
575540003633	Walker B; other site
575540003634	D-loop; other site
575540003635	H-loop/switch region; other site
575540003636	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
575540003637	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540003638	HEAT repeats; Region: HEAT_2; pfam13646
575540003639	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
575540003640	HEAT repeats; Region: HEAT_2; pfam13646
575540003641	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
575540003642	HEAT repeats; Region: HEAT_2; pfam13646
575540003643	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540003644	Cytochrome c; Region: Cytochrom_C; cl11414
575540003645	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
575540003646	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
575540003647	tetramer interface [polypeptide binding]; other site
575540003648	active site
575540003649	Mg2+/Mn2+ binding site [ion binding]; other site
575540003650	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
575540003651	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
575540003652	substrate binding site [chemical binding]; other site
575540003653	ATP binding site [chemical binding]; other site
575540003654	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
575540003655	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
575540003656	DNA binding site [nucleotide binding]
575540003657	catalytic residue [active]
575540003658	H2TH interface [polypeptide binding]; other site
575540003659	putative catalytic residues [active]
575540003660	turnover-facilitating residue; other site
575540003661	intercalation triad [nucleotide binding]; other site
575540003662	8OG recognition residue [nucleotide binding]; other site
575540003663	putative reading head residues; other site
575540003664	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
575540003665	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
575540003666	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003667	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
575540003668	lipoyl synthase; Provisional; Region: PRK05481
575540003669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540003670	FeS/SAM binding site; other site
575540003671	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
575540003672	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
575540003673	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
575540003674	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003675	Walker A/P-loop; other site
575540003676	ATP binding site [chemical binding]; other site
575540003677	Q-loop/lid; other site
575540003678	ABC transporter signature motif; other site
575540003679	Walker B; other site
575540003680	D-loop; other site
575540003681	H-loop/switch region; other site
575540003682	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
575540003683	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540003684	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540003685	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
575540003686	active site
575540003687	catalytic triad [active]
575540003688	dimer interface [polypeptide binding]; other site
575540003689	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003690	Walker A motif; other site
575540003691	ATP binding site [chemical binding]; other site
575540003692	Family description; Region: UvrD_C_2; cl15862
575540003693	Sodium:solute symporter family; Region: SSF; cl00456
575540003694	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
575540003695	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540003696	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
575540003697	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540003698	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
575540003699	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540003700	DNA binding residues [nucleotide binding]
575540003701	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003702	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724
575540003703	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
575540003704	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
575540003705	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
575540003706	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
575540003707	Helix-turn-helix domains; Region: HTH; cl00088
575540003708	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
575540003709	FeoA domain; Region: FeoA; cl00838
575540003710	Domain of unknown function (DUF427); Region: DUF427; cl00998
575540003711	Peptidase S46; Region: Peptidase_S46; pfam10459
575540003712	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540003713	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540003714	EamA-like transporter family; Region: EamA; cl01037
575540003715	EamA-like transporter family; Region: EamA; cl01037
575540003716	threonine synthase; Validated; Region: PRK07591
575540003717	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
575540003718	homodimer interface [polypeptide binding]; other site
575540003719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540003720	catalytic residue [active]
575540003721	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
575540003722	MoaE interaction surface [polypeptide binding]; other site
575540003723	MoeB interaction surface [polypeptide binding]; other site
575540003724	thiocarboxylated glycine; other site
575540003725	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
575540003726	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
575540003727	ATP binding site [chemical binding]; other site
575540003728	substrate interface [chemical binding]; other site
575540003729	Protein of unknown function (DUF1525); Region: DUF1525; cl06515
575540003730	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
575540003731	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540003732	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540003733	catalytic residue [active]
575540003734	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
575540003735	Peptidase family M1; Region: Peptidase_M1; pfam01433
575540003736	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540003737	Zn binding site [ion binding]; other site
575540003738	Zn binding site [ion binding]; other site
575540003739	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
575540003740	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540003741	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
575540003742	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
575540003743	NAD(P) binding site [chemical binding]; other site
575540003744	Clp protease; Region: CLP_protease; pfam00574
575540003745	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
575540003746	oligomer interface [polypeptide binding]; other site
575540003747	active site residues [active]
575540003748	Clp protease; Region: CLP_protease; pfam00574
575540003749	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
575540003750	oligomer interface [polypeptide binding]; other site
575540003751	active site residues [active]
575540003752	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
575540003753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540003754	FeS/SAM binding site; other site
575540003755	Predicted amidohydrolase [General function prediction only]; Region: COG0388
575540003756	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
575540003757	putative active site [active]
575540003758	catalytic triad [active]
575540003759	dimer interface [polypeptide binding]; other site
575540003760	Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770
575540003761	Pyruvate formate lyase 1; Region: PFL1; cd01678
575540003762	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
575540003763	coenzyme A binding site [chemical binding]; other site
575540003764	active site
575540003765	catalytic residues [active]
575540003766	glycine loop; other site
575540003767	Putative zinc-finger; Region: zf-HC2; cl15806
575540003768	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
575540003769	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540003770	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540003771	DNA binding residues [nucleotide binding]
575540003772	Flp/Fap pilin component; Region: Flp_Fap; cl01585
575540003773	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
575540003774	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
575540003775	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
575540003776	MASE1; Region: MASE1; pfam05231
575540003777	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
575540003778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540003779	dimer interface [polypeptide binding]; other site
575540003780	phosphorylation site [posttranslational modification]
575540003781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540003782	ATP binding site [chemical binding]; other site
575540003783	Mg2+ binding site [ion binding]; other site
575540003784	G-X-G motif; other site
575540003785	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003787	active site
575540003788	phosphorylation site [posttranslational modification]
575540003789	intermolecular recognition site; other site
575540003790	dimerization interface [polypeptide binding]; other site
575540003791	SAF domain; Region: SAF; cl00555
575540003792	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
575540003793	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
575540003794	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540003795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
575540003796	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540003797	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
575540003798	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288
575540003799	putative active site [active]
575540003800	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
575540003801	SOUL heme-binding protein; Region: SOUL; pfam04832
575540003802	DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796
575540003803	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
575540003804	active site
575540003805	primer binding site [nucleotide binding]; other site
575540003806	NTP  binding site [chemical binding]; other site
575540003807	metal binding triad [ion binding]; metal-binding site
575540003808	hypothetical protein; Provisional; Region: PRK08609
575540003809	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
575540003810	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540003811	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
575540003812	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
575540003813	active site
575540003814	trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018
575540003815	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540003816	catalytic residues [active]
575540003817	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
575540003818	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003819	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
575540003820	Walker A/P-loop; other site
575540003821	ATP binding site [chemical binding]; other site
575540003822	Q-loop/lid; other site
575540003823	ABC transporter signature motif; other site
575540003824	Walker B; other site
575540003825	D-loop; other site
575540003826	H-loop/switch region; other site
575540003827	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
575540003828	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
575540003829	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
575540003830	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
575540003831	dimer interface [polypeptide binding]; other site
575540003832	anticodon binding site; other site
575540003833	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
575540003834	homodimer interface [polypeptide binding]; other site
575540003835	motif 1; other site
575540003836	active site
575540003837	motif 2; other site
575540003838	GAD domain; Region: GAD; pfam02938
575540003839	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
575540003840	motif 3; other site
575540003841	Uncharacterized conserved protein [Function unknown]; Region: COG1700
575540003842	Protein of unknown function (DUF524); Region: DUF524; pfam04411
575540003843	Intermediate filament protein; Region: Filament; pfam00038
575540003844	Siah interacting protein, N terminal; Region: Siah-Interact_N; pfam09032
575540003845	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
575540003846	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
575540003847	active site
575540003848	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
575540003849	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
575540003850	putative active site [active]
575540003851	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
575540003852	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
575540003853	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003854	Walker A/P-loop; other site
575540003855	ATP binding site [chemical binding]; other site
575540003856	Q-loop/lid; other site
575540003857	ABC transporter signature motif; other site
575540003858	Walker B; other site
575540003859	D-loop; other site
575540003860	H-loop/switch region; other site
575540003861	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
575540003862	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
575540003863	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003864	Walker A/P-loop; other site
575540003865	ATP binding site [chemical binding]; other site
575540003866	Q-loop/lid; other site
575540003867	ABC transporter signature motif; other site
575540003868	Walker B; other site
575540003869	D-loop; other site
575540003870	H-loop/switch region; other site
575540003871	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
575540003872	TIGR00300 family protein; Region: TIGR00300
575540003873	LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455
575540003874	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
575540003875	PDGLE domain; Region: PDGLE; cl07986
575540003876	Cobalt transport protein; Region: CbiQ; cl00463
575540003877	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
575540003878	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
575540003879	Walker A/P-loop; other site
575540003880	ATP binding site [chemical binding]; other site
575540003881	Q-loop/lid; other site
575540003882	ABC transporter signature motif; other site
575540003883	Walker B; other site
575540003884	D-loop; other site
575540003885	H-loop/switch region; other site
575540003886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003887	NAD(P) binding site [chemical binding]; other site
575540003888	active site
575540003889	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540003890	Sulfatase; Region: Sulfatase; cl10460
575540003891	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
575540003892	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
575540003893	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
575540003894	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
575540003895	Surface antigen; Region: Bac_surface_Ag; cl03097
575540003896	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540003897	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540003898	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540003899	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540003900	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
575540003901	classical (c) SDRs; Region: SDR_c; cd05233
575540003902	NAD(P) binding site [chemical binding]; other site
575540003903	active site
575540003904	Protein kinase domain; Region: Pkinase; pfam00069
575540003905	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540003906	active site
575540003907	ATP binding site [chemical binding]; other site
575540003908	substrate binding site [chemical binding]; other site
575540003909	activation loop (A-loop); other site
575540003910	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540003911	active site
575540003912	ATP binding site [chemical binding]; other site
575540003913	substrate binding site [chemical binding]; other site
575540003914	activation loop (A-loop); other site
575540003915	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
575540003916	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
575540003917	RNA binding surface [nucleotide binding]; other site
575540003918	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
575540003919	active site
575540003920	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540003921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003922	TPR motif; other site
575540003923	binding surface
575540003924	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540003925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540003926	binding surface
575540003927	TPR motif; other site
575540003928	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
575540003929	Tetratricopeptide repeat; Region: TPR_6; pfam13174
575540003930	thiamine monophosphate kinase; Provisional; Region: PRK05731
575540003931	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
575540003932	ATP binding site [chemical binding]; other site
575540003933	dimerization interface [polypeptide binding]; other site
575540003934	Glycerate kinase family; Region: Gly_kinase; cl00841
575540003935	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003937	active site
575540003938	phosphorylation site [posttranslational modification]
575540003939	intermolecular recognition site; other site
575540003940	dimerization interface [polypeptide binding]; other site
575540003941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
575540003942	dimer interface [polypeptide binding]; other site
575540003943	phosphorylation site [posttranslational modification]
575540003944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540003945	ATP binding site [chemical binding]; other site
575540003946	Mg2+ binding site [ion binding]; other site
575540003947	G-X-G motif; other site
575540003948	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
575540003949	Predicted amidohydrolase [General function prediction only]; Region: COG0388
575540003950	multimer interface [polypeptide binding]; other site
575540003951	active site
575540003952	catalytic triad [active]
575540003953	protein interface 1 [polypeptide binding]; other site
575540003954	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
575540003955	Ligand Binding Site [chemical binding]; other site
575540003956	translocation protein TolB; Provisional; Region: tolB; PRK01029
575540003957	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
575540003958	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540003959	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540003960	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
575540003961	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
575540003962	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
575540003963	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
575540003964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540003965	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
575540003966	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
575540003967	active site
575540003968	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
575540003969	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
575540003970	NAD binding site [chemical binding]; other site
575540003971	substrate binding site [chemical binding]; other site
575540003972	homodimer interface [polypeptide binding]; other site
575540003973	active site
575540003974	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
575540003975	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
575540003976	substrate binding site; other site
575540003977	tetramer interface; other site
575540003978	Cupin domain; Region: Cupin_2; cl09118
575540003979	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003981	active site
575540003982	phosphorylation site [posttranslational modification]
575540003983	intermolecular recognition site; other site
575540003984	dimerization interface [polypeptide binding]; other site
575540003985	L-lactate permease; Region: Lactate_perm; cl00701
575540003986	probable methyltransferase; Region: TIGR03438
575540003987	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
575540003988	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
575540003989	SprT-like family; Region: SprT-like; pfam10263
575540003990	glutathione synthetase; Provisional; Region: PRK05246
575540003991	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
575540003992	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540003993	Predicted transcriptional regulators [Transcription]; Region: COG1510
575540003994	Helix-turn-helix domains; Region: HTH; cl00088
575540003995	Response regulator receiver domain; Region: Response_reg; pfam00072
575540003996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540003997	active site
575540003998	phosphorylation site [posttranslational modification]
575540003999	intermolecular recognition site; other site
575540004000	dimerization interface [polypeptide binding]; other site
575540004001	PAS domain; Region: PAS_9; pfam13426
575540004002	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
575540004003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540004004	putative active site [active]
575540004005	heme pocket [chemical binding]; other site
575540004006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540004007	dimer interface [polypeptide binding]; other site
575540004008	phosphorylation site [posttranslational modification]
575540004009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540004010	ATP binding site [chemical binding]; other site
575540004011	G-X-G motif; other site
575540004012	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
575540004013	SurA N-terminal domain; Region: SurA_N_3; cl07813
575540004014	PPIC-type PPIASE domain; Region: Rotamase; cl08278
575540004015	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
575540004016	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540004017	phosphopeptide binding site; other site
575540004018	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
575540004019	Uncharacterized conserved protein [Function unknown]; Region: COG1912
575540004020	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
575540004021	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540004022	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540004023	Spore germination protein; Region: Spore_permease; cl15802
575540004024	Spore germination protein; Region: Spore_permease; cl15802
575540004025	Spore germination protein; Region: Spore_permease; cl15802
575540004026	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
575540004027	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004028	DEAD_2; Region: DEAD_2; pfam06733
575540004029	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004030	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
575540004031	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
575540004032	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
575540004033	putative active site [active]
575540004034	putative metal binding site [ion binding]; other site
575540004035	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
575540004036	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
575540004037	active site
575540004038	catalytic tetrad [active]
575540004039	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540004040	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540004041	active site
575540004042	Protein of unknown function (DUF971); Region: DUF971; cl01414
575540004043	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540004044	HEAT repeats; Region: HEAT_2; pfam13646
575540004045	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540004046	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
575540004047	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540004048	Sulfatase; Region: Sulfatase; cl10460
575540004049	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
575540004050	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
575540004051	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
575540004052	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
575540004053	nucleoside transporter; Region: nupC; TIGR00804
575540004054	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
575540004055	Nucleoside recognition; Region: Gate; cl00486
575540004056	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
575540004057	dihydroorotase; Validated; Region: pyrC; PRK09357
575540004058	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540004059	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
575540004060	active site
575540004061	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
575540004062	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
575540004063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004064	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540004065	active site
575540004066	Fasciclin domain; Region: Fasciclin; cl02663
575540004067	FIST N domain; Region: FIST; cl10701
575540004068	FIST C domain; Region: FIST_C; pfam10442
575540004069	Domain of unknown function DUF87; Region: DUF87; pfam01935
575540004070	AAA-like domain; Region: AAA_10; pfam12846
575540004071	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
575540004072	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
575540004073	Walker A/P-loop; other site
575540004074	ATP binding site [chemical binding]; other site
575540004075	Q-loop/lid; other site
575540004076	ABC transporter signature motif; other site
575540004077	Walker B; other site
575540004078	D-loop; other site
575540004079	H-loop/switch region; other site
575540004080	TOBE-like domain; Region: TOBE_3; pfam12857
575540004081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540004082	dimer interface [polypeptide binding]; other site
575540004083	conserved gate region; other site
575540004084	putative PBP binding loops; other site
575540004085	ABC-ATPase subunit interface; other site
575540004086	sulfate transport protein; Provisional; Region: cysT; CHL00187
575540004087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540004088	dimer interface [polypeptide binding]; other site
575540004089	conserved gate region; other site
575540004090	putative PBP binding loops; other site
575540004091	ABC-ATPase subunit interface; other site
575540004092	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540004093	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
575540004094	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540004095	The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474
575540004096	Predicted RNA interaction site [nucleotide binding]; other site
575540004097	putative binding site; other site
575540004098	Mutations affecting start-site selection; other site
575540004099	aromatic acid decarboxylase; Validated; Region: PRK05920
575540004100	Flavoprotein; Region: Flavoprotein; cl08021
575540004101	short chain dehydrogenase; Provisional; Region: PRK06181
575540004102	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004103	NAD(P) binding site [chemical binding]; other site
575540004104	active site
575540004105	UbiA prenyltransferase family; Region: UbiA; cl00337
575540004106	OpgC protein; Region: OpgC_C; cl00792
575540004107	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
575540004108	Proteins of 100 residues with WXG; Region: WXG100; cl02005
575540004109	Copper resistance protein D; Region: CopD; cl00563
575540004110	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
575540004111	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004112	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
575540004113	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
575540004114	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
575540004115	XdhC Rossmann domain; Region: XdhC_C; pfam13478
575540004116	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
575540004117	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
575540004118	Ligand binding site; other site
575540004119	metal-binding site
575540004120	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
575540004121	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
575540004122	ATP binding site [chemical binding]; other site
575540004123	Mg++ binding site [ion binding]; other site
575540004124	motif III; other site
575540004125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540004126	nucleotide binding region [chemical binding]; other site
575540004127	ATP-binding site [chemical binding]; other site
575540004128	TPR repeat; Region: TPR_11; pfam13414
575540004129	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540004130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004131	TPR motif; other site
575540004132	binding surface
575540004133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004134	TPR motif; other site
575540004135	binding surface
575540004136	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
575540004137	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
575540004138	substrate binding site [chemical binding]; other site
575540004139	Ferredoxin [Energy production and conversion]; Region: COG1146
575540004140	4Fe-4S binding domain; Region: Fer4; cl02805
575540004141	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
575540004142	PUA domain; Region: PUA; cl00607
575540004143	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
575540004144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540004145	S-adenosylmethionine binding site [chemical binding]; other site
575540004146	GTPase RsgA; Reviewed; Region: PRK00098
575540004147	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
575540004148	GTPase/Zn-binding domain interface [polypeptide binding]; other site
575540004149	GTP/Mg2+ binding site [chemical binding]; other site
575540004150	G4 box; other site
575540004151	G5 box; other site
575540004152	G1 box; other site
575540004153	Switch I region; other site
575540004154	G2 box; other site
575540004155	G3 box; other site
575540004156	Switch II region; other site
575540004157	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
575540004158	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
575540004159	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
575540004160	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
575540004161	dimerization interface [polypeptide binding]; other site
575540004162	FAD binding pocket [chemical binding]; other site
575540004163	FAD binding motif [chemical binding]; other site
575540004164	catalytic residues [active]
575540004165	NAD binding pocket [chemical binding]; other site
575540004166	phosphate binding motif [ion binding]; other site
575540004167	beta-alpha-beta structure motif; other site
575540004168	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
575540004169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004170	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540004171	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
575540004172	substrate binding pocket [chemical binding]; other site
575540004173	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540004174	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540004175	metal ion-dependent adhesion site (MIDAS); other site
575540004176	Transcriptional regulator; Region: Transcrip_reg; cl00361
575540004177	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
575540004178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004179	TPR motif; other site
575540004180	binding surface
575540004181	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
575540004182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004183	TPR motif; other site
575540004184	binding surface
575540004185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004186	TPR motif; other site
575540004187	binding surface
575540004188	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540004189	Fasciclin domain; Region: Fasciclin; cl02663
575540004190	Ribosome-binding factor A; Region: RBFA; cl00542
575540004191	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
575540004192	translation initiation factor IF-2; Region: IF-2; TIGR00487
575540004193	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
575540004194	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
575540004195	G1 box; other site
575540004196	putative GEF interaction site [polypeptide binding]; other site
575540004197	GTP/Mg2+ binding site [chemical binding]; other site
575540004198	Switch I region; other site
575540004199	G2 box; other site
575540004200	G3 box; other site
575540004201	Switch II region; other site
575540004202	G4 box; other site
575540004203	G5 box; other site
575540004204	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
575540004205	Translation-initiation factor 2; Region: IF-2; pfam11987
575540004206	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
575540004207	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
575540004208	NusA N-terminal domain; Region: NusA_N; pfam08529
575540004209	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
575540004210	RNA binding site [nucleotide binding]; other site
575540004211	homodimer interface [polypeptide binding]; other site
575540004212	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
575540004213	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
575540004214	G-X-X-G motif; other site
575540004215	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
575540004216	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
575540004217	metal binding site 2 [ion binding]; metal-binding site
575540004218	putative DNA binding helix; other site
575540004219	metal binding site 1 [ion binding]; metal-binding site
575540004220	dimer interface [polypeptide binding]; other site
575540004221	structural Zn2+ binding site [ion binding]; other site
575540004222	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
575540004223	active site
575540004224	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540004225	structural tetrad; other site
575540004226	FOG: WD40 repeat [General function prediction only]; Region: COG2319
575540004227	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540004228	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
575540004229	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004230	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004231	active site
575540004232	ATP binding site [chemical binding]; other site
575540004233	substrate binding site [chemical binding]; other site
575540004234	activation loop (A-loop); other site
575540004235	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540004236	FOG: WD40 repeat [General function prediction only]; Region: COG2319
575540004237	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540004238	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540004239	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
575540004240	iron-sulfur cluster [ion binding]; other site
575540004241	[2Fe-2S] cluster binding site [ion binding]; other site
575540004242	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540004243	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540004244	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
575540004245	Walker A/P-loop; other site
575540004246	ATP binding site [chemical binding]; other site
575540004247	Q-loop/lid; other site
575540004248	ABC transporter signature motif; other site
575540004249	Walker B; other site
575540004250	D-loop; other site
575540004251	H-loop/switch region; other site
575540004252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
575540004253	non-specific DNA binding site [nucleotide binding]; other site
575540004254	salt bridge; other site
575540004255	sequence-specific DNA binding site [nucleotide binding]; other site
575540004256	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540004257	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
575540004258	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
575540004259	ADP-glucose phosphorylase; Region: PLN02643
575540004260	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
575540004261	nucleotide binding site/active site [active]
575540004262	HIT family signature motif; other site
575540004263	catalytic residue [active]
575540004264	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
575540004265	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
575540004266	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
575540004267	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
575540004268	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
575540004269	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540004270	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
575540004271	RNA binding site [nucleotide binding]; other site
575540004272	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
575540004273	RNA binding site [nucleotide binding]; other site
575540004274	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
575540004275	RNA binding site [nucleotide binding]; other site
575540004276	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
575540004277	RNA binding site [nucleotide binding]; other site
575540004278	domain interface; other site
575540004279	CTP synthetase; Validated; Region: pyrG; PRK05380
575540004280	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
575540004281	Catalytic site [active]
575540004282	active site
575540004283	UTP binding site [chemical binding]; other site
575540004284	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
575540004285	active site
575540004286	putative oxyanion hole; other site
575540004287	catalytic triad [active]
575540004288	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
575540004289	active site
575540004290	catalytic triad [active]
575540004291	oxyanion hole [active]
575540004292	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540004293	Sulfatase; Region: Sulfatase; cl10460
575540004294	Sulfatase; Region: Sulfatase; cl10460
575540004295	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
575540004296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540004297	active site
575540004298	phosphorylation site [posttranslational modification]
575540004299	intermolecular recognition site; other site
575540004300	dimerization interface [polypeptide binding]; other site
575540004301	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
575540004302	Zn2+ binding site [ion binding]; other site
575540004303	Mg2+ binding site [ion binding]; other site
575540004304	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
575540004305	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
575540004306	dimer interface [polypeptide binding]; other site
575540004307	putative functional site; other site
575540004308	putative MPT binding site; other site
575540004309	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540004310	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004311	active site
575540004312	ATP binding site [chemical binding]; other site
575540004313	substrate binding site [chemical binding]; other site
575540004314	activation loop (A-loop); other site
575540004315	Nitrogen regulatory protein P-II; Region: P-II; cl00412
575540004316	Global regulator protein family; Region: CsrA; cl00670
575540004317	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
575540004318	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
575540004319	active site lid residues [active]
575540004320	substrate binding pocket [chemical binding]; other site
575540004321	catalytic residues [active]
575540004322	substrate-Mg2+ binding site; other site
575540004323	aspartate-rich region 1; other site
575540004324	aspartate-rich region 2; other site
575540004325	phytoene desaturase; Region: crtI_fam; TIGR02734
575540004326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004327	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
575540004328	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
575540004329	substrate binding pocket [chemical binding]; other site
575540004330	substrate-Mg2+ binding site; other site
575540004331	aspartate-rich region 1; other site
575540004332	aspartate-rich region 2; other site
575540004333	Domain of unknown function (DUF329); Region: DUF329; cl01144
575540004334	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
575540004335	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
575540004336	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
575540004337	dimer interface [polypeptide binding]; other site
575540004338	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
575540004339	chaperone protein DnaJ; Provisional; Region: PRK10767
575540004340	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
575540004341	HSP70 interaction site [polypeptide binding]; other site
575540004342	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
575540004343	substrate binding site [polypeptide binding]; other site
575540004344	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
575540004345	Zn binding sites [ion binding]; other site
575540004346	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
575540004347	dimer interface [polypeptide binding]; other site
575540004348	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
575540004349	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
575540004350	ring oligomerisation interface [polypeptide binding]; other site
575540004351	ATP/Mg binding site [chemical binding]; other site
575540004352	stacking interactions; other site
575540004353	hinge regions; other site
575540004354	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
575540004355	oligomerisation interface [polypeptide binding]; other site
575540004356	mobile loop; other site
575540004357	roof hairpin; other site
575540004358	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
575540004359	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
575540004360	ring oligomerisation interface [polypeptide binding]; other site
575540004361	ATP/Mg binding site [chemical binding]; other site
575540004362	stacking interactions; other site
575540004363	hinge regions; other site
575540004364	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
575540004365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540004366	S-adenosylmethionine binding site [chemical binding]; other site
575540004367	N-acetylneuraminate lyase; Region: nanA; TIGR00683
575540004368	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540004369	catalytic residue [active]
575540004370	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
575540004371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540004372	S-adenosylmethionine binding site [chemical binding]; other site
575540004373	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
575540004374	Lumazine binding domain; Region: Lum_binding; pfam00677
575540004375	Lumazine binding domain; Region: Lum_binding; pfam00677
575540004376	membrane ATPase/protein kinase; Provisional; Region: PRK09435
575540004377	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
575540004378	Walker A; other site
575540004379	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
575540004380	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
575540004381	active site
575540004382	substrate binding site [chemical binding]; other site
575540004383	coenzyme B12 binding site [chemical binding]; other site
575540004384	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
575540004385	B12 binding site [chemical binding]; other site
575540004386	cobalt ligand [ion binding]; other site
575540004387	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
575540004388	heterodimer interface [polypeptide binding]; other site
575540004389	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
575540004390	substrate interaction site [chemical binding]; other site
575540004391	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
575540004392	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
575540004393	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
575540004394	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
575540004395	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
575540004396	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
575540004397	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
575540004398	carboxyltransferase (CT) interaction site; other site
575540004399	biotinylation site [posttranslational modification]; other site
575540004400	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
575540004401	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
575540004402	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
575540004403	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
575540004404	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
575540004405	dimer interface [polypeptide binding]; other site
575540004406	substrate binding site [chemical binding]; other site
575540004407	metal binding site [ion binding]; metal-binding site
575540004408	Uncharacterized conserved protein [Function unknown]; Region: COG3391
575540004409	Phosphoesterase family; Region: Phosphoesterase; cl15450
575540004410	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
575540004411	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
575540004412	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
575540004413	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
575540004414	active site
575540004415	dimer interface [polypeptide binding]; other site
575540004416	effector binding site; other site
575540004417	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
575540004418	TSCPD domain; Region: TSCPD; cl14834
575540004419	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
575540004420	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
575540004421	rRNA interaction site [nucleotide binding]; other site
575540004422	S8 interaction site; other site
575540004423	putative laminin-1 binding site; other site
575540004424	elongation factor Ts; Provisional; Region: tsf; PRK09377
575540004425	Elongation factor TS; Region: EF_TS; pfam00889
575540004426	Elongation factor TS; Region: EF_TS; pfam00889
575540004427	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
575540004428	putative nucleotide binding site [chemical binding]; other site
575540004429	uridine monophosphate binding site [chemical binding]; other site
575540004430	homohexameric interface [polypeptide binding]; other site
575540004431	ribosome recycling factor; Reviewed; Region: frr; PRK00083
575540004432	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
575540004433	hinge region; other site
575540004434	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
575540004435	Moco binding site; other site
575540004436	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540004437	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004438	active site
575540004439	ATP binding site [chemical binding]; other site
575540004440	substrate binding site [chemical binding]; other site
575540004441	activation loop (A-loop); other site
575540004442	RDD family; Region: RDD; cl00746
575540004443	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250
575540004444	30S subunit binding site; other site
575540004445	Predicted transcriptional regulator [Transcription]; Region: COG2378
575540004446	Right handed beta helix region; Region: Beta_helix; pfam13229
575540004447	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
575540004448	metal binding site [ion binding]; metal-binding site
575540004449	ligand binding site [chemical binding]; other site
575540004450	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
575540004451	Interdomain contacts; other site
575540004452	Cytokine receptor motif; other site
575540004453	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
575540004454	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
575540004455	G1 box; other site
575540004456	putative GEF interaction site [polypeptide binding]; other site
575540004457	GTP/Mg2+ binding site [chemical binding]; other site
575540004458	Switch I region; other site
575540004459	G2 box; other site
575540004460	G3 box; other site
575540004461	Switch II region; other site
575540004462	G4 box; other site
575540004463	G5 box; other site
575540004464	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
575540004465	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
575540004466	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
575540004467	Asp-box motif; other site
575540004468	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922
575540004469	Calx-beta domain; Region: Calx-beta; cl02522
575540004470	Calx-beta domain; Region: Calx-beta; cl02522
575540004471	Calx-beta domain; Region: Calx-beta; cl02522
575540004472	Calx-beta domain; Region: Calx-beta; cl02522
575540004473	Calx-beta domain; Region: Calx-beta; cl02522
575540004474	Calx-beta domain; Region: Calx-beta; cl02522
575540004475	Calx-beta domain; Region: Calx-beta; cl02522
575540004476	Calx-beta domain; Region: Calx-beta; cl02522
575540004477	Calx-beta domain; Region: Calx-beta; cl02522
575540004478	Calx-beta domain; Region: Calx-beta; cl02522
575540004479	Calx-beta domain; Region: Calx-beta; cl02522
575540004480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004481	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
575540004482	NAD(P) binding site [chemical binding]; other site
575540004483	active site
575540004484	MFS_1 like family; Region: MFS_1_like; pfam12832
575540004485	Major Facilitator Superfamily; Region: MFS_1; pfam07690
575540004486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540004487	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540004488	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
575540004489	Outer membrane efflux protein; Region: OEP; pfam02321
575540004490	Outer membrane efflux protein; Region: OEP; pfam02321
575540004491	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
575540004492	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
575540004493	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540004494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540004495	homodimer interface [polypeptide binding]; other site
575540004496	catalytic residue [active]
575540004497	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
575540004498	catalytic center binding site [active]
575540004499	ATP binding site [chemical binding]; other site
575540004500	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
575540004501	Helix-turn-helix domains; Region: HTH; cl00088
575540004502	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
575540004503	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
575540004504	Propanediol utilisation protein PduL; Region: PduL; pfam06130
575540004505	Propanediol utilisation protein PduL; Region: PduL; pfam06130
575540004506	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
575540004507	Hexamer interface [polypeptide binding]; other site
575540004508	Hexagonal pore residue; other site
575540004509	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
575540004510	Hexamer interface [polypeptide binding]; other site
575540004511	Hexagonal pore residue; other site
575540004512	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
575540004513	Hexamer interface [polypeptide binding]; other site
575540004514	Hexagonal pore residue; other site
575540004515	Acetokinase family; Region: Acetate_kinase; cl01029
575540004516	propionate/acetate kinase; Provisional; Region: PRK12379
575540004517	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
575540004518	Hexamer/Pentamer interface [polypeptide binding]; other site
575540004519	central pore; other site
575540004520	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
575540004521	NAD(P) binding site [chemical binding]; other site
575540004522	catalytic residues [active]
575540004523	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
575540004524	Hexamer/Pentamer interface [polypeptide binding]; other site
575540004525	central pore; other site
575540004526	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889
575540004527	Hexamer/Pentamer interface [polypeptide binding]; other site
575540004528	central pore; other site
575540004529	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
575540004530	intersubunit interface [polypeptide binding]; other site
575540004531	active site
575540004532	Zn2+ binding site [ion binding]; other site
575540004533	L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300
575540004534	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
575540004535	NAD(P) binding site [chemical binding]; other site
575540004536	dimer interface [polypeptide binding]; other site
575540004537	tetramer (dimer of dimers) interface [polypeptide binding]; other site
575540004538	substrate binding site [chemical binding]; other site
575540004539	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540004540	catalytic residue [active]
575540004541	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540004542	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004543	active site
575540004544	ATP binding site [chemical binding]; other site
575540004545	substrate binding site [chemical binding]; other site
575540004546	activation loop (A-loop); other site
575540004547	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540004548	structural tetrad; other site
575540004549	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004550	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004551	active site
575540004552	ATP binding site [chemical binding]; other site
575540004553	substrate binding site [chemical binding]; other site
575540004554	activation loop (A-loop); other site
575540004555	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540004556	structural tetrad; other site
575540004557	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
575540004558	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
575540004559	inhibitor-cofactor binding pocket; inhibition site
575540004560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540004561	catalytic residue [active]
575540004562	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
575540004563	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
575540004564	minor groove reading motif; other site
575540004565	helix-hairpin-helix signature motif; other site
575540004566	substrate binding pocket [chemical binding]; other site
575540004567	active site
575540004568	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
575540004569	active site
575540004570	multimer interface [polypeptide binding]; other site
575540004571	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540004572	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
575540004573	active site residue [active]
575540004574	VPS10 domain; Region: VPS10; smart00602
575540004575	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540004576	protein binding site [polypeptide binding]; other site
575540004577	VPS10 domain; Region: VPS10; smart00602
575540004578	VPS10 domain; Region: VPS10; smart00602
575540004579	elongation factor G; Reviewed; Region: PRK00007
575540004580	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
575540004581	G1 box; other site
575540004582	putative GEF interaction site [polypeptide binding]; other site
575540004583	GTP/Mg2+ binding site [chemical binding]; other site
575540004584	Switch I region; other site
575540004585	G2 box; other site
575540004586	G3 box; other site
575540004587	Switch II region; other site
575540004588	G4 box; other site
575540004589	G5 box; other site
575540004590	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
575540004591	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
575540004592	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
575540004593	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
575540004594	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
575540004595	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
575540004596	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540004597	Protein of unknown function (DUF721); Region: DUF721; cl02324
575540004598	DNA topoisomerase II large subunit; Provisional; Region: 39; PHA02569
575540004599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540004600	ATP binding site [chemical binding]; other site
575540004601	Mg2+ binding site [ion binding]; other site
575540004602	G-X-G motif; other site
575540004603	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
575540004604	anchoring element; other site
575540004605	dimer interface [polypeptide binding]; other site
575540004606	ATP binding site [chemical binding]; other site
575540004607	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
575540004608	active site
575540004609	putative metal-binding site [ion binding]; other site
575540004610	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
575540004611	large tegument protein UL36; Provisional; Region: PHA03247
575540004612	SWIM zinc finger; Region: SWIM; cl15408
575540004613	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
575540004614	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540004615	ATP binding site [chemical binding]; other site
575540004616	putative Mg++ binding site [ion binding]; other site
575540004617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540004618	nucleotide binding region [chemical binding]; other site
575540004619	ATP-binding site [chemical binding]; other site
575540004620	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
575540004621	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540004622	putative active site [active]
575540004623	putative metal binding site [ion binding]; other site
575540004624	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
575540004625	active site
575540004626	Zn binding site [ion binding]; other site
575540004627	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
575540004628	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
575540004629	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540004630	protein-export membrane protein SecD; Region: secD; TIGR01129
575540004631	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
575540004632	Protein export membrane protein; Region: SecD_SecF; cl14618
575540004633	Protein export membrane protein; Region: SecD_SecF; cl14618
575540004634	Preprotein translocase subunit; Region: YajC; cl00806
575540004635	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
575540004636	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
575540004637	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540004638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540004639	binding surface
575540004640	TPR motif; other site
575540004641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004642	binding surface
575540004643	TPR motif; other site
575540004644	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
575540004645	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
575540004646	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004647	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004648	active site
575540004649	ATP binding site [chemical binding]; other site
575540004650	substrate binding site [chemical binding]; other site
575540004651	activation loop (A-loop); other site
575540004652	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
575540004653	PPIC-type PPIASE domain; Region: Rotamase; cl08278
575540004654	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540004655	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
575540004656	C-terminal peptidase (prc); Region: prc; TIGR00225
575540004657	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540004658	protein binding site [polypeptide binding]; other site
575540004659	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
575540004660	Active site serine [active]
575540004661	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
575540004662	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540004663	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
575540004664	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
575540004665	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
575540004666	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540004667	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540004668	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540004669	Walker A/P-loop; other site
575540004670	ATP binding site [chemical binding]; other site
575540004671	Q-loop/lid; other site
575540004672	ABC transporter signature motif; other site
575540004673	Walker B; other site
575540004674	D-loop; other site
575540004675	H-loop/switch region; other site
575540004676	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
575540004677	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
575540004678	MPT binding site; other site
575540004679	trimer interface [polypeptide binding]; other site
575540004680	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540004681	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004682	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004683	active site
575540004684	ATP binding site [chemical binding]; other site
575540004685	substrate binding site [chemical binding]; other site
575540004686	activation loop (A-loop); other site
575540004687	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004688	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
575540004689	Walker A/P-loop; other site
575540004690	ATP binding site [chemical binding]; other site
575540004691	Q-loop/lid; other site
575540004692	ABC transporter signature motif; other site
575540004693	Walker B; other site
575540004694	D-loop; other site
575540004695	H-loop/switch region; other site
575540004696	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540004697	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004698	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004699	active site
575540004700	ATP binding site [chemical binding]; other site
575540004701	substrate binding site [chemical binding]; other site
575540004702	activation loop (A-loop); other site
575540004703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004704	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
575540004705	ADP-ribose binding site [chemical binding]; other site
575540004706	dimer interface [polypeptide binding]; other site
575540004707	active site
575540004708	nudix motif; other site
575540004709	metal binding site [ion binding]; metal-binding site
575540004710	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
575540004711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004712	CoA-ligase; Region: Ligase_CoA; cl02894
575540004713	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
575540004714	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540004715	CoA-ligase; Region: Ligase_CoA; cl02894
575540004716	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
575540004717	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
575540004718	putative ADP-binding pocket [chemical binding]; other site
575540004719	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
575540004720	Domain of unknown function DUF20; Region: UPF0118; pfam01594
575540004721	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
575540004722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540004723	ATP binding site [chemical binding]; other site
575540004724	Mg2+ binding site [ion binding]; other site
575540004725	G-X-G motif; other site
575540004726	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
575540004727	ATP binding site [chemical binding]; other site
575540004728	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
575540004729	Type III pantothenate kinase; Region: Pan_kinase; cl09130
575540004730	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
575540004731	GTP1/OBG; Region: GTP1_OBG; pfam01018
575540004732	Obg GTPase; Region: Obg; cd01898
575540004733	G1 box; other site
575540004734	GTP/Mg2+ binding site [chemical binding]; other site
575540004735	Switch I region; other site
575540004736	G2 box; other site
575540004737	G3 box; other site
575540004738	Switch II region; other site
575540004739	G4 box; other site
575540004740	G5 box; other site
575540004741	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
575540004742	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
575540004743	Ligand Binding Site [chemical binding]; other site
575540004744	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
575540004745	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
575540004746	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
575540004747	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
575540004748	active site
575540004749	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
575540004750	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
575540004751	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
575540004752	active site
575540004753	trimer interface [polypeptide binding]; other site
575540004754	allosteric site; other site
575540004755	active site lid [active]
575540004756	TPR repeat; Region: TPR_11; pfam13414
575540004757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004758	TPR motif; other site
575540004759	binding surface
575540004760	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540004761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540004762	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540004763	binding surface
575540004764	TPR motif; other site
575540004765	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540004766	Cytochrome c; Region: Cytochrom_C; cl11414
575540004767	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540004768	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540004769	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540004770	CAAX protease self-immunity; Region: Abi; cl00558
575540004771	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
575540004772	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
575540004773	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
575540004774	Walker A/P-loop; other site
575540004775	ATP binding site [chemical binding]; other site
575540004776	Q-loop/lid; other site
575540004777	ABC transporter signature motif; other site
575540004778	Walker B; other site
575540004779	D-loop; other site
575540004780	H-loop/switch region; other site
575540004781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540004782	dimer interface [polypeptide binding]; other site
575540004783	conserved gate region; other site
575540004784	putative PBP binding loops; other site
575540004785	ABC-ATPase subunit interface; other site
575540004786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540004787	dimer interface [polypeptide binding]; other site
575540004788	conserved gate region; other site
575540004789	putative PBP binding loops; other site
575540004790	ABC-ATPase subunit interface; other site
575540004791	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540004792	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
575540004793	DsrE/DsrF-like family; Region: DrsE; cl00672
575540004794	DsrE/DsrF-like family; Region: DrsE; cl00672
575540004795	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004796	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
575540004797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004798	binding surface
575540004799	TPR motif; other site
575540004800	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
575540004801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540004802	FeS/SAM binding site; other site
575540004803	enolase; Provisional; Region: eno; PRK00077
575540004804	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
575540004805	dimer interface [polypeptide binding]; other site
575540004806	metal binding site [ion binding]; metal-binding site
575540004807	substrate binding pocket [chemical binding]; other site
575540004808	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540004809	catalytic core [active]
575540004810	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540004811	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
575540004812	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
575540004813	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
575540004814	Integral membrane protein TerC family; Region: TerC; cl10468
575540004815	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
575540004816	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
575540004817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004818	L-type amino acid transporter; Region: 2A0308; TIGR00911
575540004819	Spore germination protein; Region: Spore_permease; cl15802
575540004820	HEAT-like repeat; Region: HEAT_EZ; pfam13513
575540004821	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
575540004822	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
575540004823	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540004824	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540004825	active site
575540004826	ATP binding site [chemical binding]; other site
575540004827	substrate binding site [chemical binding]; other site
575540004828	activation loop (A-loop); other site
575540004829	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540004830	phosphate binding site [ion binding]; other site
575540004831	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
575540004832	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
575540004833	Walker A/P-loop; other site
575540004834	ATP binding site [chemical binding]; other site
575540004835	Q-loop/lid; other site
575540004836	ABC transporter signature motif; other site
575540004837	Walker B; other site
575540004838	D-loop; other site
575540004839	H-loop/switch region; other site
575540004840	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
575540004841	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
575540004842	substrate binding pocket [chemical binding]; other site
575540004843	membrane-bound complex binding site; other site
575540004844	hinge residues; other site
575540004845	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
575540004846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540004847	dimer interface [polypeptide binding]; other site
575540004848	conserved gate region; other site
575540004849	putative PBP binding loops; other site
575540004850	ABC-ATPase subunit interface; other site
575540004851	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
575540004852	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
575540004853	ligand binding site; other site
575540004854	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
575540004855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540004856	Walker A motif; other site
575540004857	ATP binding site [chemical binding]; other site
575540004858	Walker B motif; other site
575540004859	arginine finger; other site
575540004860	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
575540004861	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
575540004862	active site
575540004863	catalytic tetrad [active]
575540004864	Carbon starvation protein CstA; Region: CstA; pfam02554
575540004865	Carbon starvation protein CstA; Region: CstA; pfam02554
575540004866	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
575540004867	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
575540004868	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
575540004869	Permease; Region: Permease; cl00510
575540004870	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
575540004871	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
575540004872	Walker A/P-loop; other site
575540004873	ATP binding site [chemical binding]; other site
575540004874	Q-loop/lid; other site
575540004875	ABC transporter signature motif; other site
575540004876	Walker B; other site
575540004877	D-loop; other site
575540004878	H-loop/switch region; other site
575540004879	mce related protein; Region: MCE; pfam02470
575540004880	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
575540004881	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540004882	binding surface
575540004883	TPR motif; other site
575540004884	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540004885	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540004886	active site
575540004887	metal binding site [ion binding]; metal-binding site
575540004888	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
575540004889	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
575540004890	putative ribose interaction site [chemical binding]; other site
575540004891	putative ADP binding site [chemical binding]; other site
575540004892	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540004893	active site
575540004894	nucleotide binding site [chemical binding]; other site
575540004895	HIGH motif; other site
575540004896	KMSKS motif; other site
575540004897	Predicted ATPase [General function prediction only]; Region: COG4637
575540004898	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540004899	Walker B; other site
575540004900	D-loop; other site
575540004901	H-loop/switch region; other site
575540004902	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
575540004903	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540004904	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
575540004905	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540004906	NHL repeat; Region: NHL; pfam01436
575540004907	NHL repeat; Region: NHL; pfam01436
575540004908	Domain of unknown function DUF59; Region: DUF59; cl00941
575540004909	antiporter inner membrane protein; Provisional; Region: PRK11670
575540004910	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
575540004911	Walker A motif; other site
575540004912	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540004913	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
575540004914	active site
575540004915	putative substrate binding region [chemical binding]; other site
575540004916	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540004917	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
575540004918	active site
575540004919	Uncharacterized conserved protein [Function unknown]; Region: COG0585
575540004920	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
575540004921	active site
575540004922	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
575540004923	Flp/Fap pilin component; Region: Flp_Fap; cl01585
575540004924	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
575540004925	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
575540004926	metal binding site [ion binding]; metal-binding site
575540004927	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
575540004928	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
575540004929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540004930	active site
575540004931	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
575540004932	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
575540004933	FMN binding site [chemical binding]; other site
575540004934	active site
575540004935	catalytic residues [active]
575540004936	substrate binding site [chemical binding]; other site
575540004937	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
575540004938	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
575540004939	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
575540004940	TPP-binding site; other site
575540004941	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
575540004942	PYR/PP interface [polypeptide binding]; other site
575540004943	dimer interface [polypeptide binding]; other site
575540004944	TPP binding site [chemical binding]; other site
575540004945	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
575540004946	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
575540004947	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
575540004948	substrate binding pocket [chemical binding]; other site
575540004949	chain length determination region; other site
575540004950	substrate-Mg2+ binding site; other site
575540004951	catalytic residues [active]
575540004952	aspartate-rich region 1; other site
575540004953	active site lid residues [active]
575540004954	aspartate-rich region 2; other site
575540004955	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
575540004956	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
575540004957	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
575540004958	enoyl-CoA hydratase; Provisional; Region: PRK05995
575540004959	substrate binding site [chemical binding]; other site
575540004960	oxyanion hole (OAH) forming residues; other site
575540004961	trimer interface [polypeptide binding]; other site
575540004962	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
575540004963	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
575540004964	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540004965	putative active site [active]
575540004966	putative metal binding site [ion binding]; other site
575540004967	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540004968	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
575540004969	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
575540004970	active site
575540004971	(T/H)XGH motif; other site
575540004972	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
575540004973	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540004974	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540004975	catalytic residue [active]
575540004976	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004977	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004978	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004979	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004980	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004981	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004982	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004983	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004984	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004985	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004986	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004987	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
575540004988	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
575540004989	AsmA-like C-terminal region; Region: AsmA_2; cl15864
575540004990	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
575540004991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540004992	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
575540004993	active site
575540004994	dimer interface [polypeptide binding]; other site
575540004995	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540004996	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540004997	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540004998	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540004999	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540005000	Right handed beta helix region; Region: Beta_helix; pfam13229
575540005001	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
575540005002	Right handed beta helix region; Region: Beta_helix; pfam13229
575540005003	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
575540005004	putative active site [active]
575540005005	catalytic triad [active]
575540005006	LabA_like proteins; Region: LabA_like; cd06167
575540005007	putative metal binding site [ion binding]; other site
575540005008	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
575540005009	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
575540005010	dimerization interface [polypeptide binding]; other site
575540005011	ATP binding site [chemical binding]; other site
575540005012	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
575540005013	dimerization interface [polypeptide binding]; other site
575540005014	ATP binding site [chemical binding]; other site
575540005015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005016	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
575540005017	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
575540005018	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540005019	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
575540005020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540005021	DNA binding residues [nucleotide binding]
575540005022	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
575540005023	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
575540005024	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540005025	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005026	active site
575540005027	ATP binding site [chemical binding]; other site
575540005028	substrate binding site [chemical binding]; other site
575540005029	activation loop (A-loop); other site
575540005030	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540005031	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540005032	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
575540005033	active site
575540005034	dimer interface [polypeptide binding]; other site
575540005035	metal binding site [ion binding]; metal-binding site
575540005036	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668
575540005037	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
575540005038	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
575540005039	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540005040	active site
575540005041	ATP binding site [chemical binding]; other site
575540005042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
575540005043	Bacterial transcriptional activator domain; Region: BTAD; smart01043
575540005044	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
575540005045	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
575540005046	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
575540005047	SmpB-tmRNA interface; other site
575540005048	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
575540005049	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
575540005050	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
575540005051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540005052	ATP binding site [chemical binding]; other site
575540005053	putative Mg++ binding site [ion binding]; other site
575540005054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540005055	nucleotide binding region [chemical binding]; other site
575540005056	ATP-binding site [chemical binding]; other site
575540005057	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005058	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005059	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
575540005060	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
575540005061	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
575540005062	Tetratricopeptide repeat; Region: TPR_6; pfam13174
575540005063	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540005064	active site
575540005065	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
575540005066	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
575540005067	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
575540005068	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
575540005069	dimer interface [polypeptide binding]; other site
575540005070	putative CheW interface [polypeptide binding]; other site
575540005071	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540005072	putative binding surface; other site
575540005073	active site
575540005074	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
575540005075	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540005076	putative binding surface; other site
575540005077	active site
575540005078	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
575540005079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540005080	ATP binding site [chemical binding]; other site
575540005081	Mg2+ binding site [ion binding]; other site
575540005082	G-X-G motif; other site
575540005083	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
575540005084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005085	active site
575540005086	phosphorylation site [posttranslational modification]
575540005087	intermolecular recognition site; other site
575540005088	dimerization interface [polypeptide binding]; other site
575540005089	Response regulator receiver domain; Region: Response_reg; pfam00072
575540005090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005091	active site
575540005092	phosphorylation site [posttranslational modification]
575540005093	intermolecular recognition site; other site
575540005094	dimerization interface [polypeptide binding]; other site
575540005095	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
575540005096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005097	active site
575540005098	phosphorylation site [posttranslational modification]
575540005099	intermolecular recognition site; other site
575540005100	dimerization interface [polypeptide binding]; other site
575540005101	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540005102	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540005103	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
575540005104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
575540005105	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
575540005106	dimerization interface [polypeptide binding]; other site
575540005107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540005108	dimer interface [polypeptide binding]; other site
575540005109	phosphorylation site [posttranslational modification]
575540005110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540005111	ATP binding site [chemical binding]; other site
575540005112	Mg2+ binding site [ion binding]; other site
575540005113	G-X-G motif; other site
575540005114	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
575540005115	DNA-K related protein; Region: DUF3731; pfam12531
575540005116	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540005117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005118	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540005119	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
575540005120	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
575540005121	active site
575540005122	metal binding site [ion binding]; metal-binding site
575540005123	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
575540005124	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540005125	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005126	FeoA domain; Region: FeoA; cl00838
575540005127	FeoA domain; Region: FeoA; cl00838
575540005128	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
575540005129	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
575540005130	G1 box; other site
575540005131	GTP/Mg2+ binding site [chemical binding]; other site
575540005132	Switch I region; other site
575540005133	G2 box; other site
575540005134	G3 box; other site
575540005135	Switch II region; other site
575540005136	G4 box; other site
575540005137	G5 box; other site
575540005138	Nucleoside recognition; Region: Gate; cl00486
575540005139	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
575540005140	Nucleoside recognition; Region: Gate; cl00486
575540005141	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540005142	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
575540005143	oligomerization interface [polypeptide binding]; other site
575540005144	active site
575540005145	metal binding site [ion binding]; metal-binding site
575540005146	FAD binding domain; Region: FAD_binding_4; pfam01565
575540005147	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
575540005148	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540005149	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005150	Walker A/P-loop; other site
575540005151	ATP binding site [chemical binding]; other site
575540005152	Q-loop/lid; other site
575540005153	ABC transporter signature motif; other site
575540005154	Walker B; other site
575540005155	D-loop; other site
575540005156	H-loop/switch region; other site
575540005157	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540005158	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
575540005159	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
575540005160	TPR repeat; Region: TPR_11; pfam13414
575540005161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005162	binding surface
575540005163	TPR motif; other site
575540005164	TPR repeat; Region: TPR_11; pfam13414
575540005165	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540005166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005167	TPR motif; other site
575540005168	binding surface
575540005169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005170	TPR repeat; Region: TPR_11; pfam13414
575540005171	binding surface
575540005172	TPR motif; other site
575540005173	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
575540005174	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
575540005175	active site
575540005176	HIGH motif; other site
575540005177	dimer interface [polypeptide binding]; other site
575540005178	KMSKS motif; other site
575540005179	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540005180	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
575540005181	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
575540005182	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
575540005183	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
575540005184	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
575540005185	catalytic site [active]
575540005186	G-X2-G-X-G-K; other site
575540005187	hypothetical protein; Provisional; Region: PRK11820
575540005188	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
575540005189	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
575540005190	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
575540005191	substrate binding site [chemical binding]; other site
575540005192	dimer interface [polypeptide binding]; other site
575540005193	catalytic triad [active]
575540005194	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005195	active site
575540005196	ATP binding site [chemical binding]; other site
575540005197	substrate binding site [chemical binding]; other site
575540005198	activation loop (A-loop); other site
575540005199	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005200	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005202	binding surface
575540005203	TPR motif; other site
575540005204	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005205	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005207	binding surface
575540005208	TPR motif; other site
575540005209	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005210	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540005212	binding surface
575540005213	TPR motif; other site
575540005214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005215	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540005217	binding surface
575540005218	TPR motif; other site
575540005219	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540005220	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
575540005221	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
575540005222	metal binding site [ion binding]; metal-binding site
575540005223	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
575540005224	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
575540005225	putative active site [active]
575540005226	oxyanion strand; other site
575540005227	catalytic triad [active]
575540005228	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
575540005229	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
575540005230	catalytic residues [active]
575540005231	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
575540005232	elongation factor G; Reviewed; Region: PRK12740
575540005233	G1 box; other site
575540005234	putative GEF interaction site [polypeptide binding]; other site
575540005235	GTP/Mg2+ binding site [chemical binding]; other site
575540005236	Switch I region; other site
575540005237	G2 box; other site
575540005238	G3 box; other site
575540005239	Switch II region; other site
575540005240	G4 box; other site
575540005241	G5 box; other site
575540005242	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
575540005243	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
575540005244	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
575540005245	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540005246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005247	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
575540005248	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
575540005249	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
575540005250	dimerization interface [polypeptide binding]; other site
575540005251	active site
575540005252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005253	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540005254	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005255	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
575540005256	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
575540005257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540005258	FeS/SAM binding site; other site
575540005259	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
575540005260	putative active site [active]
575540005261	putative metal binding residues [ion binding]; other site
575540005262	signature motif; other site
575540005263	putative triphosphate binding site [ion binding]; other site
575540005264	dimer interface [polypeptide binding]; other site
575540005265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
575540005266	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
575540005267	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540005268	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
575540005269	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
575540005270	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540005271	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540005272	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005273	active site
575540005274	ATP binding site [chemical binding]; other site
575540005275	substrate binding site [chemical binding]; other site
575540005276	activation loop (A-loop); other site
575540005277	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540005278	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540005279	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
575540005280	putative ADP-binding pocket [chemical binding]; other site
575540005281	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540005282	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
575540005283	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
575540005284	putative metal binding site; other site
575540005285	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540005286	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
575540005287	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005288	Walker A/P-loop; other site
575540005289	ATP binding site [chemical binding]; other site
575540005290	Q-loop/lid; other site
575540005291	ABC transporter signature motif; other site
575540005292	Walker B; other site
575540005293	D-loop; other site
575540005294	H-loop/switch region; other site
575540005295	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
575540005296	active site
575540005297	catalytic triad [active]
575540005298	oxyanion hole [active]
575540005299	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540005300	HEAT repeats; Region: HEAT_2; pfam13646
575540005301	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540005302	Cytochrome c; Region: Cytochrom_C; cl11414
575540005303	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
575540005304	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540005305	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540005306	active site
575540005307	metal binding site [ion binding]; metal-binding site
575540005308	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540005309	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
575540005310	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
575540005311	metal binding site [ion binding]; metal-binding site
575540005312	dimer interface [polypeptide binding]; other site
575540005313	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
575540005314	Cu(I) binding site [ion binding]; other site
575540005315	Protein of unknown function (DUF420); Region: DUF420; cl00989
575540005316	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
575540005317	DNA binding residues [nucleotide binding]
575540005318	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
575540005319	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
575540005320	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
575540005321	5'-3' exonuclease; Region: 53EXOc; smart00475
575540005322	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
575540005323	active site
575540005324	metal binding site 1 [ion binding]; metal-binding site
575540005325	putative 5' ssDNA interaction site; other site
575540005326	metal binding site 3; metal-binding site
575540005327	metal binding site 2 [ion binding]; metal-binding site
575540005328	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
575540005329	putative DNA binding site [nucleotide binding]; other site
575540005330	putative metal binding site [ion binding]; other site
575540005331	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
575540005332	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
575540005333	active site
575540005334	substrate binding site [chemical binding]; other site
575540005335	catalytic site [active]
575540005336	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
575540005337	active site
575540005338	DNA binding site [nucleotide binding]
575540005339	catalytic site [active]
575540005340	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
575540005341	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
575540005342	Citrate synthase; Region: Citrate_synt; pfam00285
575540005343	oxalacetate binding site [chemical binding]; other site
575540005344	citrylCoA binding site [chemical binding]; other site
575540005345	coenzyme A binding site [chemical binding]; other site
575540005346	catalytic triad [active]
575540005347	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
575540005348	classical (c) SDRs; Region: SDR_c; cd05233
575540005349	NAD(P) binding site [chemical binding]; other site
575540005350	active site
575540005351	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005352	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
575540005353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540005354	S-adenosylmethionine binding site [chemical binding]; other site
575540005355	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
575540005356	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
575540005357	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
575540005358	GIY-YIG motif/motif A; other site
575540005359	active site
575540005360	catalytic site [active]
575540005361	putative DNA binding site [nucleotide binding]; other site
575540005362	metal binding site [ion binding]; metal-binding site
575540005363	UvrB/uvrC motif; Region: UVR; pfam02151
575540005364	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
575540005365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005366	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005367	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
575540005368	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540005369	phosphopeptide binding site; other site
575540005370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
575540005371	metal binding site [ion binding]; metal-binding site
575540005372	active site
575540005373	I-site; other site
575540005374	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
575540005375	dimer interface [polypeptide binding]; other site
575540005376	catalytic triad [active]
575540005377	peroxidatic and resolving cysteines [active]
575540005378	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
575540005379	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005380	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
575540005381	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
575540005382	DNA binding residues [nucleotide binding]
575540005383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005384	active site
575540005385	phosphorylation site [posttranslational modification]
575540005386	intermolecular recognition site; other site
575540005387	dimerization interface [polypeptide binding]; other site
575540005388	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
575540005389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540005390	phosphorylation site [posttranslational modification]
575540005391	dimer interface [polypeptide binding]; other site
575540005392	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
575540005393	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540005394	CAAX protease self-immunity; Region: Abi; cl00558
575540005395	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
575540005396	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005397	Walker A/P-loop; other site
575540005398	ATP binding site [chemical binding]; other site
575540005399	Q-loop/lid; other site
575540005400	ABC transporter signature motif; other site
575540005401	Walker B; other site
575540005402	D-loop; other site
575540005403	H-loop/switch region; other site
575540005404	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
575540005405	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
575540005406	Ligand Binding Site [chemical binding]; other site
575540005407	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
575540005408	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
575540005409	NAD(P) binding site [chemical binding]; other site
575540005410	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540005411	active site
575540005412	catalytic residues [active]
575540005413	Cytochrome c; Region: Cytochrom_C; cl11414
575540005414	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540005415	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540005416	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540005417	ribonuclease D; Region: rnd; TIGR01388
575540005418	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
575540005419	putative active site [active]
575540005420	catalytic site [active]
575540005421	putative substrate binding site [chemical binding]; other site
575540005422	HRDC domain; Region: HRDC; cl02578
575540005423	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540005424	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005425	active site
575540005426	ATP binding site [chemical binding]; other site
575540005427	substrate binding site [chemical binding]; other site
575540005428	activation loop (A-loop); other site
575540005429	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540005430	Uncharacterized conserved protein [Function unknown]; Region: COG1262
575540005431	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540005432	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
575540005433	Domain of unknown function DUF21; Region: DUF21; pfam01595
575540005434	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
575540005435	Transporter associated domain; Region: CorC_HlyC; cl08393
575540005436	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
575540005437	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
575540005438	interchain domain interface [polypeptide binding]; other site
575540005439	intrachain domain interface; other site
575540005440	heme bH binding site [chemical binding]; other site
575540005441	heme bL binding site [chemical binding]; other site
575540005442	Qo binding site; other site
575540005443	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
575540005444	intrachain domain interface; other site
575540005445	Qi binding site; other site
575540005446	Qo binding site; other site
575540005447	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
575540005448	Cytochrome c; Region: Cytochrom_C; cl11414
575540005449	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
575540005450	iron-sulfur cluster [ion binding]; other site
575540005451	[2Fe-2S] cluster binding site [ion binding]; other site
575540005452	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540005453	phosphopeptide binding site; other site
575540005454	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540005455	phosphopeptide binding site; other site
575540005456	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
575540005457	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
575540005458	putative NADP binding site [chemical binding]; other site
575540005459	putative substrate binding site [chemical binding]; other site
575540005460	active site
575540005461	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540005462	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540005463	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
575540005464	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540005465	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
575540005466	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
575540005467	motif 1; other site
575540005468	active site
575540005469	motif 2; other site
575540005470	motif 3; other site
575540005471	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
575540005472	DHHA1 domain; Region: DHHA1; pfam02272
575540005473	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
575540005474	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
575540005475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540005476	S-adenosylmethionine binding site [chemical binding]; other site
575540005477	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
575540005478	recombinase A; Provisional; Region: recA; PRK09354
575540005479	hexamer interface [polypeptide binding]; other site
575540005480	Walker A motif; other site
575540005481	ATP binding site [chemical binding]; other site
575540005482	Walker B motif; other site
575540005483	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
575540005484	Predicted peptidase [General function prediction only]; Region: COG4099
575540005485	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540005486	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
575540005487	active site
575540005488	motif I; other site
575540005489	motif II; other site
575540005490	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540005491	Family description; Region: VCBS; pfam13517
575540005492	Family description; Region: VCBS; pfam13517
575540005493	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
575540005494	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
575540005495	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
575540005496	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540005497	catalytic residue [active]
575540005498	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
575540005499	trimerization site [polypeptide binding]; other site
575540005500	active site
575540005501	PA14 domain; Region: PA14; cl08459
575540005502	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
575540005503	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
575540005504	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
575540005505	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
575540005506	dimer interface [polypeptide binding]; other site
575540005507	active site
575540005508	CoA binding pocket [chemical binding]; other site
575540005509	PAS fold; Region: PAS_3; pfam08447
575540005510	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540005511	putative active site [active]
575540005512	heme pocket [chemical binding]; other site
575540005513	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
575540005514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540005515	dimer interface [polypeptide binding]; other site
575540005516	phosphorylation site [posttranslational modification]
575540005517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540005518	ATP binding site [chemical binding]; other site
575540005519	Mg2+ binding site [ion binding]; other site
575540005520	G-X-G motif; other site
575540005521	Response regulator receiver domain; Region: Response_reg; pfam00072
575540005522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005523	active site
575540005524	phosphorylation site [posttranslational modification]
575540005525	intermolecular recognition site; other site
575540005526	dimerization interface [polypeptide binding]; other site
575540005527	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540005528	putative binding surface; other site
575540005529	active site
575540005530	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
575540005531	Phage T7 capsid assembly protein; Region: Phage_T7_Capsid; cl14192
575540005532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540005533	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540005534	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540005535	metal ion-dependent adhesion site (MIDAS); other site
575540005536	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
575540005537	metal binding site 2 [ion binding]; metal-binding site
575540005538	putative DNA binding helix; other site
575540005539	metal binding site 1 [ion binding]; metal-binding site
575540005540	dimer interface [polypeptide binding]; other site
575540005541	structural Zn2+ binding site [ion binding]; other site
575540005542	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
575540005543	Active_site [active]
575540005544	Domain of unknown function (DUF303); Region: DUF303; pfam03629
575540005545	P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302
575540005546	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
575540005547	active site
575540005548	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540005549	catalytic residues [active]
575540005550	large tegument protein UL36; Provisional; Region: PHA03247
575540005551	glycogen synthase; Provisional; Region: glgA; PRK00654
575540005552	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
575540005553	ADP-binding pocket [chemical binding]; other site
575540005554	homodimer interface [polypeptide binding]; other site
575540005555	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540005556	HEAT repeats; Region: HEAT_2; pfam13646
575540005557	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540005558	Cytochrome c; Region: Cytochrom_C; cl11414
575540005559	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540005560	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540005561	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540005562	DNA binding residues [nucleotide binding]
575540005563	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
575540005564	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
575540005565	active site residue [active]
575540005566	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
575540005567	active site residue [active]
575540005568	Global regulator protein family; Region: CsrA; cl00670
575540005569	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
575540005570	FMN binding site [chemical binding]; other site
575540005571	substrate binding site [chemical binding]; other site
575540005572	putative catalytic residue [active]
575540005573	potential frameshift: common BLAST hit: gi|148264069|ref|YP_001230775.1| erythronolide synthase
575540005574	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
575540005575	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
575540005576	active site
575540005577	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
575540005578	Acyl transferase domain; Region: Acyl_transf_1; cl08282
575540005579	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540005580	Phosphopantetheine attachment site; Region: PP-binding; cl09936
575540005581	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
575540005582	putative NADP binding site [chemical binding]; other site
575540005583	active site
575540005584	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
575540005585	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
575540005586	active site
575540005587	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
575540005588	active site
575540005589	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
575540005590	Acyl transferase domain; Region: Acyl_transf_1; cl08282
575540005591	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
575540005592	active site 2 [active]
575540005593	dimer interface [polypeptide binding]; other site
575540005594	active site 1 [active]
575540005595	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
575540005596	active site 1 [active]
575540005597	dimer interface [polypeptide binding]; other site
575540005598	active site 2 [active]
575540005599	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
575540005600	active site 2 [active]
575540005601	active site 1 [active]
575540005602	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
575540005603	active site 2 [active]
575540005604	active site 1 [active]
575540005605	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
575540005606	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
575540005607	dimer interface [polypeptide binding]; other site
575540005608	active site
575540005609	CoA binding pocket [chemical binding]; other site
575540005610	haloalkane dehalogenase; Provisional; Region: PRK03204
575540005611	Sulfatase; Region: Sulfatase; cl10460
575540005612	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
575540005613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540005614	putative substrate translocation pore; other site
575540005615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540005616	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540005617	Sulfatase; Region: Sulfatase; cl10460
575540005618	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
575540005619	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005620	Family description; Region: UvrD_C_2; cl15862
575540005621	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
575540005622	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005623	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
575540005624	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005625	active site
575540005626	ATP binding site [chemical binding]; other site
575540005627	substrate binding site [chemical binding]; other site
575540005628	activation loop (A-loop); other site
575540005629	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
575540005630	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540005631	metal ion-dependent adhesion site (MIDAS); other site
575540005632	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
575540005633	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264
575540005634	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
575540005635	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
575540005636	dimer interface [polypeptide binding]; other site
575540005637	active site
575540005638	aspartate-rich active site metal binding site; other site
575540005639	allosteric magnesium binding site [ion binding]; other site
575540005640	Schiff base residues; other site
575540005641	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540005642	Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516
575540005643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
575540005644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540005645	dimer interface [polypeptide binding]; other site
575540005646	phosphorylation site [posttranslational modification]
575540005647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540005648	ATP binding site [chemical binding]; other site
575540005649	Mg2+ binding site [ion binding]; other site
575540005650	G-X-G motif; other site
575540005651	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
575540005652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540005653	active site
575540005654	phosphorylation site [posttranslational modification]
575540005655	intermolecular recognition site; other site
575540005656	dimerization interface [polypeptide binding]; other site
575540005657	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540005658	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
575540005659	dimer interface [polypeptide binding]; other site
575540005660	substrate binding site [chemical binding]; other site
575540005661	ATP binding site [chemical binding]; other site
575540005662	UvrB/uvrC motif; Region: UVR; pfam02151
575540005663	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
575540005664	putative active site [active]
575540005665	BNR repeat-like domain; Region: BNR_2; pfam13088
575540005666	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
575540005667	classical (c) SDRs; Region: SDR_c; cd05233
575540005668	NAD(P) binding site [chemical binding]; other site
575540005669	active site
575540005670	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
575540005671	iron-sulfur cluster [ion binding]; other site
575540005672	[2Fe-2S] cluster binding site [ion binding]; other site
575540005673	Cytochrome c; Region: Cytochrom_C; cl11414
575540005674	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540005675	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540005676	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540005677	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
575540005678	NeuB family; Region: NeuB; cl00496
575540005679	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
575540005680	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
575540005681	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
575540005682	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540005683	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540005684	phosphopeptide binding site; other site
575540005685	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540005686	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005687	active site
575540005688	ATP binding site [chemical binding]; other site
575540005689	substrate binding site [chemical binding]; other site
575540005690	activation loop (A-loop); other site
575540005691	trehalose synthase; Region: treS_nterm; TIGR02456
575540005692	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
575540005693	active site
575540005694	catalytic site [active]
575540005695	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
575540005696	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
575540005697	HSP70 interaction site [polypeptide binding]; other site
575540005698	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
575540005699	substrate binding site [polypeptide binding]; other site
575540005700	dimer interface [polypeptide binding]; other site
575540005701	Ribonuclease P; Region: Ribonuclease_P; cl00457
575540005702	Haemolytic domain; Region: Haemolytic; cl00506
575540005703	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540005704	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
575540005705	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
575540005706	active site
575540005707	Zn binding site [ion binding]; other site
575540005708	thioester reductase domain; Region: Thioester-redct; TIGR01746
575540005709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005710	NAD(P) binding site [chemical binding]; other site
575540005711	active site
575540005712	GTP-binding protein YchF; Reviewed; Region: PRK09601
575540005713	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005714	GTP/Mg2+ binding site [chemical binding]; other site
575540005715	Switch I region; other site
575540005716	G3 box; other site
575540005717	Switch II region; other site
575540005718	G4 box; other site
575540005719	G5 box; other site
575540005720	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
575540005721	amidophosphoribosyltransferase; Region: purF; TIGR01134
575540005722	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
575540005723	active site
575540005724	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540005725	active site
575540005726	gamma-glutamyl kinase; Provisional; Region: PRK05429
575540005727	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
575540005728	nucleotide binding site [chemical binding]; other site
575540005729	homotetrameric interface [polypeptide binding]; other site
575540005730	putative phosphate binding site [ion binding]; other site
575540005731	putative allosteric binding site; other site
575540005732	PUA domain; Region: PUA; cl00607
575540005733	Colicin V production protein; Region: Colicin_V; cl00567
575540005734	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
575540005735	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005736	NAD(P) binding site [chemical binding]; other site
575540005737	active site
575540005738	methionine aminopeptidase; Provisional; Region: PRK12318
575540005739	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
575540005740	active site
575540005741	NeuB family; Region: NeuB; cl00496
575540005742	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
575540005743	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
575540005744	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
575540005745	active site residue [active]
575540005746	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
575540005747	active site residue [active]
575540005748	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
575540005749	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
575540005750	NADP binding site [chemical binding]; other site
575540005751	dimer interface [polypeptide binding]; other site
575540005752	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540005754	S-adenosylmethionine binding site [chemical binding]; other site
575540005755	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540005756	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540005757	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
575540005758	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
575540005759	active site
575540005760	Protein of unknown function DUF111; Region: DUF111; cl03398
575540005761	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
575540005762	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
575540005763	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
575540005764	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
575540005765	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
575540005766	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
575540005767	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
575540005768	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
575540005769	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
575540005770	protein-rRNA interface [nucleotide binding]; other site
575540005771	putative translocon binding site; other site
575540005772	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
575540005773	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
575540005774	G-X-X-G motif; other site
575540005775	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
575540005776	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
575540005777	23S rRNA interface [nucleotide binding]; other site
575540005778	5S rRNA interface [nucleotide binding]; other site
575540005779	putative antibiotic binding site [chemical binding]; other site
575540005780	L25 interface [polypeptide binding]; other site
575540005781	L27 interface [polypeptide binding]; other site
575540005782	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
575540005783	23S rRNA interface [nucleotide binding]; other site
575540005784	putative translocon interaction site; other site
575540005785	signal recognition particle (SRP54) interaction site; other site
575540005786	L23 interface [polypeptide binding]; other site
575540005787	trigger factor interaction site; other site
575540005788	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
575540005789	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
575540005790	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
575540005791	KOW motif; Region: KOW; cl00354
575540005792	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
575540005793	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
575540005794	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
575540005795	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
575540005796	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
575540005797	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
575540005798	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
575540005799	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
575540005800	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
575540005801	5S rRNA interface [nucleotide binding]; other site
575540005802	23S rRNA interface [nucleotide binding]; other site
575540005803	L27 interface [polypeptide binding]; other site
575540005804	L5 interface [polypeptide binding]; other site
575540005805	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
575540005806	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
575540005807	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
575540005808	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
575540005809	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
575540005810	SecY translocase; Region: SecY; pfam00344
575540005811	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
575540005812	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
575540005813	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
575540005814	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
575540005815	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
575540005816	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
575540005817	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
575540005818	RNA binding surface [nucleotide binding]; other site
575540005819	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
575540005820	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
575540005821	alphaNTD homodimer interface [polypeptide binding]; other site
575540005822	alphaNTD - beta interaction site [polypeptide binding]; other site
575540005823	alphaNTD - beta' interaction site [polypeptide binding]; other site
575540005824	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
575540005825	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
575540005826	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
575540005827	HIT family signature motif; other site
575540005828	catalytic residue [active]
575540005829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005830	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
575540005831	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
575540005832	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540005833	NAD(P) binding site [chemical binding]; other site
575540005834	active site
575540005835	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
575540005836	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
575540005837	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
575540005838	substrate binding site [chemical binding]; other site
575540005839	active site
575540005840	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540005841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540005842	Walker A/P-loop; other site
575540005843	ATP binding site [chemical binding]; other site
575540005844	Q-loop/lid; other site
575540005845	ABC transporter signature motif; other site
575540005846	Walker B; other site
575540005847	D-loop; other site
575540005848	H-loop/switch region; other site
575540005849	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540005850	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540005851	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540005852	Walker A/P-loop; other site
575540005853	ATP binding site [chemical binding]; other site
575540005854	Q-loop/lid; other site
575540005855	ABC transporter signature motif; other site
575540005856	Walker B; other site
575540005857	D-loop; other site
575540005858	H-loop/switch region; other site
575540005859	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540005860	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
575540005861	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
575540005862	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
575540005863	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
575540005864	tandem repeat interface [polypeptide binding]; other site
575540005865	oligomer interface [polypeptide binding]; other site
575540005866	active site residues [active]
575540005867	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540005868	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
575540005869	FtsX-like permease family; Region: FtsX; cl15850
575540005870	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540005871	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540005872	Walker A/P-loop; other site
575540005873	ATP binding site [chemical binding]; other site
575540005874	Q-loop/lid; other site
575540005875	ABC transporter signature motif; other site
575540005876	Walker B; other site
575540005877	D-loop; other site
575540005878	H-loop/switch region; other site
575540005879	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540005880	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
575540005881	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540005882	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540005883	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
575540005884	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
575540005885	Walker A/P-loop; other site
575540005886	ATP binding site [chemical binding]; other site
575540005887	Q-loop/lid; other site
575540005888	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
575540005889	ABC transporter signature motif; other site
575540005890	Walker B; other site
575540005891	D-loop; other site
575540005892	H-loop/switch region; other site
575540005893	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
575540005894	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
575540005895	PQQ-like domain; Region: PQQ_2; pfam13360
575540005896	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
575540005897	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
575540005898	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
575540005899	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540005900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540005901	catalytic residue [active]
575540005902	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
575540005903	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
575540005904	dimer interface [polypeptide binding]; other site
575540005905	glycine-pyridoxal phosphate binding site [chemical binding]; other site
575540005906	active site
575540005907	folate binding site [chemical binding]; other site
575540005908	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540005909	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540005910	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540005911	Metal-binding active site; metal-binding site
575540005912	Protein kinase domain; Region: Pkinase; pfam00069
575540005913	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005914	active site
575540005915	ATP binding site [chemical binding]; other site
575540005916	substrate binding site [chemical binding]; other site
575540005917	activation loop (A-loop); other site
575540005918	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005919	active site
575540005920	ATP binding site [chemical binding]; other site
575540005921	substrate binding site [chemical binding]; other site
575540005922	activation loop (A-loop); other site
575540005923	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540005924	GH3 auxin-responsive promoter; Region: GH3; cl04006
575540005925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540005926	S-adenosylmethionine binding site [chemical binding]; other site
575540005927	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
575540005928	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540005929	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
575540005930	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
575540005931	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540005932	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540005933	ABC transporter; Region: ABC_tran_2; pfam12848
575540005934	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540005935	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
575540005936	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
575540005937	DNA polymerase III subunit beta; Validated; Region: PRK05643
575540005938	putative DNA binding surface [nucleotide binding]; other site
575540005939	dimer interface [polypeptide binding]; other site
575540005940	beta-clamp/clamp loader binding surface; other site
575540005941	beta-clamp/translesion DNA polymerase binding surface; other site
575540005942	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
575540005943	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
575540005944	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
575540005945	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
575540005946	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
575540005947	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
575540005948	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
575540005949	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
575540005950	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
575540005951	putative NAD(P) binding site [chemical binding]; other site
575540005952	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540005953	Major Facilitator Superfamily; Region: MFS_1; pfam07690
575540005954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540005955	TPR repeat; Region: TPR_11; pfam13414
575540005956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540005957	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
575540005958	catalytic triad [active]
575540005959	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540005960	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540005961	active site
575540005962	ATP binding site [chemical binding]; other site
575540005963	substrate binding site [chemical binding]; other site
575540005964	activation loop (A-loop); other site
575540005965	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540005966	GAF domain; Region: GAF; cl15785
575540005967	HlyD family secretion protein; Region: HlyD_2; pfam12700
575540005968	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540005969	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540005970	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540005971	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540005972	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
575540005973	active site
575540005974	putative substrate binding region [chemical binding]; other site
575540005975	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540005976	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540005977	LabA_like proteins; Region: LabA_like; cd06167
575540005978	putative metal binding site [ion binding]; other site
575540005979	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
575540005980	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540005981	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
575540005982	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
575540005983	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
575540005984	active site
575540005985	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
575540005986	carboxyltransferase (CT) interaction site; other site
575540005987	biotinylation site [posttranslational modification]; other site
575540005988	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
575540005989	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
575540005990	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
575540005991	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
575540005992	ligand binding site [chemical binding]; other site
575540005993	active site
575540005994	UGI interface [polypeptide binding]; other site
575540005995	catalytic site [active]
575540005996	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
575540005997	GSH binding site [chemical binding]; other site
575540005998	catalytic residues [active]
575540005999	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
575540006000	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
575540006001	4Fe-4S binding domain; Region: Fer4; cl02805
575540006002	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
575540006003	[4Fe-4S] binding site [ion binding]; other site
575540006004	molybdopterin cofactor binding site; other site
575540006005	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
575540006006	molybdopterin cofactor binding site; other site
575540006007	Protein of unknown function (DUF556); Region: DUF556; cl00822
575540006008	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540006009	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
575540006010	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
575540006011	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
575540006012	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
575540006013	active site
575540006014	dimer interface [polypeptide binding]; other site
575540006015	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
575540006016	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006017	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006018	active site
575540006019	ATP binding site [chemical binding]; other site
575540006020	substrate binding site [chemical binding]; other site
575540006021	activation loop (A-loop); other site
575540006022	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540006023	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
575540006024	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540006025	metal ion-dependent adhesion site (MIDAS); other site
575540006026	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540006027	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540006028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
575540006029	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
575540006030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
575540006031	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006032	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006033	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006034	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
575540006035	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006036	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006037	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006038	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
575540006039	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540006040	catalytic residues [active]
575540006041	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540006042	catalytic residues [active]
575540006043	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540006044	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540006045	active site
575540006046	HIGH motif; other site
575540006047	nucleotide binding site [chemical binding]; other site
575540006048	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540006049	active site
575540006050	KMSKS motif; other site
575540006051	peptide chain release factor 2; Provisional; Region: PRK05589
575540006052	RF-1 domain; Region: RF-1; cl02875
575540006053	RF-1 domain; Region: RF-1; cl02875
575540006054	Predicted amidohydrolase [General function prediction only]; Region: COG0388
575540006055	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
575540006056	active site
575540006057	catalytic triad [active]
575540006058	dimer interface [polypeptide binding]; other site
575540006059	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540006060	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540006061	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006062	hypothetical protein; Provisional; Region: PRK08317
575540006063	Sulfatase; Region: Sulfatase; cl10460
575540006064	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
575540006065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540006066	putative substrate translocation pore; other site
575540006067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540006068	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
575540006069	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006070	hypothetical protein; Provisional; Region: PRK11281
575540006071	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
575540006072	dimerization interface [polypeptide binding]; other site
575540006073	active site
575540006074	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540006075	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
575540006076	active site
575540006077	catalytic residues [active]
575540006078	Transcriptional regulator [Transcription]; Region: LysR; COG0583
575540006079	Helix-turn-helix domains; Region: HTH; cl00088
575540006080	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
575540006081	dimerization interface [polypeptide binding]; other site
575540006082	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
575540006083	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
575540006084	active site
575540006085	dimer interface [polypeptide binding]; other site
575540006086	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
575540006087	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
575540006088	active site
575540006089	FMN binding site [chemical binding]; other site
575540006090	substrate binding site [chemical binding]; other site
575540006091	3Fe-4S cluster binding site [ion binding]; other site
575540006092	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
575540006093	domain interface; other site
575540006094	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
575540006095	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006096	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006097	active site
575540006098	ATP binding site [chemical binding]; other site
575540006099	substrate binding site [chemical binding]; other site
575540006100	activation loop (A-loop); other site
575540006101	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
575540006102	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
575540006103	Heme NO binding; Region: HNOB; cl15268
575540006104	Phycobilisome protein; Region: Phycobilisome; cl08227
575540006105	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
575540006106	Heme NO binding; Region: HNOB; cl15268
575540006107	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
575540006108	catalytic loop [active]
575540006109	iron binding site [ion binding]; other site
575540006110	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
575540006111	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
575540006112	heme binding pocket [chemical binding]; other site
575540006113	heme ligand [chemical binding]; other site
575540006114	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006116	active site
575540006117	ATP binding site [chemical binding]; other site
575540006118	substrate binding site [chemical binding]; other site
575540006119	activation loop (A-loop); other site
575540006120	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006121	active site
575540006122	ATP binding site [chemical binding]; other site
575540006123	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006124	substrate binding site [chemical binding]; other site
575540006125	activation loop (A-loop); other site
575540006126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540006127	D-galactonate transporter; Region: 2A0114; TIGR00893
575540006128	putative substrate translocation pore; other site
575540006129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540006130	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
575540006131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540006132	dimer interface [polypeptide binding]; other site
575540006133	phosphorylation site [posttranslational modification]
575540006134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540006135	ATP binding site [chemical binding]; other site
575540006136	Mg2+ binding site [ion binding]; other site
575540006137	G-X-G motif; other site
575540006138	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
575540006139	trimer interface [polypeptide binding]; other site
575540006140	putative metal binding site [ion binding]; other site
575540006141	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
575540006142	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
575540006143	Zn binding site [ion binding]; other site
575540006144	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
575540006145	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540006146	Walker A/P-loop; other site
575540006147	ATP binding site [chemical binding]; other site
575540006148	Q-loop/lid; other site
575540006149	ABC transporter signature motif; other site
575540006150	Walker B; other site
575540006151	D-loop; other site
575540006152	H-loop/switch region; other site
575540006153	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
575540006154	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
575540006155	Ligand binding site; other site
575540006156	Putative Catalytic site; other site
575540006157	DXD motif; other site
575540006158	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
575540006159	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540006160	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540006161	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540006162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006163	TPR motif; other site
575540006164	binding surface
575540006165	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540006166	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540006167	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540006168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006169	TPR motif; other site
575540006170	binding surface
575540006171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006172	TPR motif; other site
575540006173	binding surface
575540006174	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006175	TPR motif; other site
575540006176	binding surface
575540006177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006178	binding surface
575540006179	TPR motif; other site
575540006180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006181	TPR motif; other site
575540006182	binding surface
575540006183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540006184	TPR motif; other site
575540006185	binding surface
575540006186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006187	binding surface
575540006188	TPR motif; other site
575540006189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006190	TPR motif; other site
575540006191	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
575540006192	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
575540006193	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
575540006194	NeuB family; Region: NeuB; cl00496
575540006195	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
575540006196	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
575540006197	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
575540006198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006199	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
575540006200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540006201	Walker A motif; other site
575540006202	ATP binding site [chemical binding]; other site
575540006203	Walker B motif; other site
575540006204	arginine finger; other site
575540006205	Helix-turn-helix domains; Region: HTH; cl00088
575540006206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006207	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
575540006208	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
575540006209	catalytic residues [active]
575540006210	Isochorismatase family; Region: Isochorismatase; pfam00857
575540006211	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
575540006212	catalytic triad [active]
575540006213	conserved cis-peptide bond; other site
575540006214	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
575540006215	PQQ-like domain; Region: PQQ_2; pfam13360
575540006216	Trp docking motif [polypeptide binding]; other site
575540006217	active site
575540006218	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
575540006219	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
575540006220	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
575540006221	active site
575540006222	Haem-binding domain; Region: Haem_bd; pfam14376
575540006223	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
575540006224	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
575540006225	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
575540006226	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
575540006227	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
575540006228	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
575540006229	Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138
575540006230	dihydrodipicolinate reductase; Provisional; Region: PRK00048
575540006231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006232	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
575540006233	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
575540006234	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
575540006235	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
575540006236	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
575540006237	Uncharacterized conserved protein [Function unknown]; Region: COG2308
575540006238	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
575540006239	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540006240	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
575540006241	NAD binding site [chemical binding]; other site
575540006242	putative substrate binding site 2 [chemical binding]; other site
575540006243	putative substrate binding site 1 [chemical binding]; other site
575540006244	active site
575540006245	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
575540006246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
575540006247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
575540006248	Protein of unknown function (DUF423); Region: DUF423; cl01008
575540006249	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
575540006250	LytB protein; Region: LYTB; cl00507
575540006251	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
575540006252	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
575540006253	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
575540006254	putative active site [active]
575540006255	substrate binding site [chemical binding]; other site
575540006256	putative cosubstrate binding site; other site
575540006257	catalytic site [active]
575540006258	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
575540006259	substrate binding site [chemical binding]; other site
575540006260	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
575540006261	active site
575540006262	catalytic residues [active]
575540006263	metal binding site [ion binding]; metal-binding site
575540006264	BNR repeat-like domain; Region: BNR_2; pfam13088
575540006265	aminoacyl-tRNA ligase; Region: PLN02563
575540006266	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
575540006267	HIGH motif; other site
575540006268	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
575540006269	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540006270	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540006271	active site
575540006272	KMSKS motif; other site
575540006273	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
575540006274	tRNA binding surface [nucleotide binding]; other site
575540006275	BON domain; Region: BON; cl02771
575540006276	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
575540006277	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
575540006278	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540006279	FeS/SAM binding site; other site
575540006280	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
575540006281	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
575540006282	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
575540006283	Active site cavity [active]
575540006284	catalytic acid [active]
575540006285	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
575540006286	MgtE intracellular N domain; Region: MgtE_N; cl15244
575540006287	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
575540006288	Divalent cation transporter; Region: MgtE; cl00786
575540006289	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
575540006290	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
575540006291	NHL repeat; Region: NHL; pfam01436
575540006292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006293	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
575540006294	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006295	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
575540006296	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
575540006297	dimer interface [polypeptide binding]; other site
575540006298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540006299	catalytic residue [active]
575540006300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006301	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
575540006302	MPN+ (JAMM) motif; other site
575540006303	Zinc-binding site [ion binding]; other site
575540006304	adenylate kinases; Region: adk; TIGR01351
575540006305	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
575540006306	AMP-binding site [chemical binding]; other site
575540006307	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
575540006308	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540006309	catalytic core [active]
575540006310	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
575540006311	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
575540006312	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
575540006313	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339
575540006314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540006315	FeS/SAM binding site; other site
575540006316	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
575540006317	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
575540006318	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
575540006319	metal binding triad; other site
575540006320	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
575540006321	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
575540006322	metal binding triad; other site
575540006323	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
575540006324	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
575540006325	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
575540006326	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
575540006327	metal binding site [ion binding]; metal-binding site
575540006328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540006329	protein binding site [polypeptide binding]; other site
575540006330	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540006331	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
575540006332	Leucine-rich repeats; other site
575540006333	Substrate binding site [chemical binding]; other site
575540006334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540006335	S-adenosylmethionine binding site [chemical binding]; other site
575540006336	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540006337	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
575540006338	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
575540006339	generic binding surface II; other site
575540006340	generic binding surface I; other site
575540006341	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
575540006342	Zn2+ binding site [ion binding]; other site
575540006343	Mg2+ binding site [ion binding]; other site
575540006344	ribonuclease R; Region: RNase_R; TIGR02063
575540006345	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
575540006346	RNB domain; Region: RNB; pfam00773
575540006347	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
575540006348	RNA binding site [nucleotide binding]; other site
575540006349	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540006350	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540006351	N-carbamolyputrescine amidase; Region: PLN02747
575540006352	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
575540006353	active site
575540006354	catalytic triad [active]
575540006355	dimer interface [polypeptide binding]; other site
575540006356	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
575540006357	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
575540006358	active site
575540006359	dimer interface [polypeptide binding]; other site
575540006360	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
575540006361	Ligand Binding Site [chemical binding]; other site
575540006362	Molecular Tunnel; other site
575540006363	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
575540006364	FliP family; Region: FliP; cl00593
575540006365	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
575540006366	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
575540006367	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
575540006368	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
575540006369	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540006370	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
575540006371	FtsX-like permease family; Region: FtsX; cl15850
575540006372	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540006373	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540006374	Walker A/P-loop; other site
575540006375	ATP binding site [chemical binding]; other site
575540006376	Q-loop/lid; other site
575540006377	ABC transporter signature motif; other site
575540006378	Walker B; other site
575540006379	D-loop; other site
575540006380	H-loop/switch region; other site
575540006381	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540006382	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540006383	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540006384	large tegument protein UL36; Provisional; Region: PHA03247
575540006385	Outer membrane efflux protein; Region: OEP; pfam02321
575540006386	FG-GAP repeat; Region: FG-GAP; cl15299
575540006387	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
575540006388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540006389	S-adenosylmethionine binding site [chemical binding]; other site
575540006390	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540006391	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
575540006392	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540006393	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540006394	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540006395	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540006396	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540006397	Acyltransferase family; Region: Acyl_transf_3; pfam01757
575540006398	OpgC protein; Region: OpgC_C; cl00792
575540006399	OpgC protein; Region: OpgC_C; cl00792
575540006400	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540006401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006402	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540006403	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540006404	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540006405	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540006406	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540006407	DNA binding residues [nucleotide binding]
575540006408	Putative zinc-finger; Region: zf-HC2; cl15806
575540006409	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
575540006410	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
575540006411	inhibitor-cofactor binding pocket; inhibition site
575540006412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540006413	catalytic residue [active]
575540006414	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
575540006415	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540006416	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
575540006417	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540006418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540006419	Walker A motif; other site
575540006420	ATP binding site [chemical binding]; other site
575540006421	Walker B motif; other site
575540006422	arginine finger; other site
575540006423	Response regulator receiver domain; Region: Response_reg; pfam00072
575540006424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540006425	active site
575540006426	phosphorylation site [posttranslational modification]
575540006427	intermolecular recognition site; other site
575540006428	dimerization interface [polypeptide binding]; other site
575540006429	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
575540006430	DHH family; Region: DHH; pfam01368
575540006431	DHHA1 domain; Region: DHHA1; pfam02272
575540006432	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
575540006433	putative ligand binding site [chemical binding]; other site
575540006434	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
575540006435	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
575540006436	ligand binding site; other site
575540006437	oligomer interface; other site
575540006438	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
575540006439	dimer interface [polypeptide binding]; other site
575540006440	N-terminal domain interface [polypeptide binding]; other site
575540006441	sulfate 1 binding site; other site
575540006442	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
575540006443	RNA/DNA binding site [nucleotide binding]; other site
575540006444	RRM dimerization site [polypeptide binding]; other site
575540006445	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006446	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006447	active site
575540006448	ATP binding site [chemical binding]; other site
575540006449	substrate binding site [chemical binding]; other site
575540006450	activation loop (A-loop); other site
575540006451	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
575540006452	putative acyl-acceptor binding pocket; other site
575540006453	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406
575540006454	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
575540006455	putative dimer interface [polypeptide binding]; other site
575540006456	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
575540006457	putative active site [active]
575540006458	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
575540006459	putative active site [active]
575540006460	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
575540006461	putative active site [active]
575540006462	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540006463	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
575540006464	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
575540006465	heme-binding residues [chemical binding]; other site
575540006466	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
575540006467	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
575540006468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540006469	FeS/SAM binding site; other site
575540006470	HemN C-terminal domain; Region: HemN_C; pfam06969
575540006471	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
575540006472	active site
575540006473	8-oxo-dGMP binding site [chemical binding]; other site
575540006474	nudix motif; other site
575540006475	metal binding site [ion binding]; metal-binding site
575540006476	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
575540006477	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
575540006478	NAD binding site [chemical binding]; other site
575540006479	homotetramer interface [polypeptide binding]; other site
575540006480	homodimer interface [polypeptide binding]; other site
575540006481	substrate binding site [chemical binding]; other site
575540006482	active site
575540006483	Dockerin type I repeat; Region: Dockerin_1; pfam00404
575540006484	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
575540006485	phosphopeptide binding site; other site
575540006486	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
575540006487	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
575540006488	Magnesium ion binding site [ion binding]; other site
575540006489	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
575540006490	putative catalytic residue [active]
575540006491	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540006492	catalytic residues [active]
575540006493	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540006494	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540006495	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540006496	Cytochrome c; Region: Cytochrom_C; cl11414
575540006497	Cytochrome c; Region: Cytochrom_C; cl11414
575540006498	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540006499	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540006500	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540006501	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
575540006502	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
575540006503	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
575540006504	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
575540006505	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
575540006506	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
575540006507	putative acyl-acceptor binding pocket; other site
575540006508	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
575540006509	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
575540006510	Predicted ATPase [General function prediction only]; Region: COG4637
575540006511	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540006512	Walker A/P-loop; other site
575540006513	ATP binding site [chemical binding]; other site
575540006514	Q-loop/lid; other site
575540006515	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
575540006516	Walker B; other site
575540006517	D-loop; other site
575540006518	H-loop/switch region; other site
575540006519	Protein of unknown function (DUF790); Region: DUF790; pfam05626
575540006520	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
575540006521	DEAD-like helicases superfamily; Region: DEXDc; smart00487
575540006522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540006523	ATP binding site [chemical binding]; other site
575540006524	putative Mg++ binding site [ion binding]; other site
575540006525	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540006526	nucleotide binding region [chemical binding]; other site
575540006527	ATP-binding site [chemical binding]; other site
575540006528	PEP-CTERM motif; Region: VPEP; cl15443
575540006529	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540006530	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540006531	active site
575540006532	ATP binding site [chemical binding]; other site
575540006533	substrate binding site [chemical binding]; other site
575540006534	activation loop (A-loop); other site
575540006535	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540006536	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
575540006537	Competence protein; Region: Competence; cl00471
575540006538	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540006539	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006540	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540006541	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
575540006542	Clp protease; Region: CLP_protease; pfam00574
575540006543	oligomer interface [polypeptide binding]; other site
575540006544	active site residues [active]
575540006545	trigger factor; Region: tig; TIGR00115
575540006546	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
575540006547	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
575540006548	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
575540006549	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
575540006550	active site
575540006551	catalytic site [active]
575540006552	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540006553	catalytic core [active]
575540006554	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
575540006555	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
575540006556	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
575540006557	putative dimer interface [polypeptide binding]; other site
575540006558	active site pocket [active]
575540006559	putative cataytic base [active]
575540006560	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
575540006561	Ligand Binding Site [chemical binding]; other site
575540006562	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
575540006563	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
575540006564	cobalamin binding residues [chemical binding]; other site
575540006565	putative BtuC binding residues; other site
575540006566	dimer interface [polypeptide binding]; other site
575540006567	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
575540006568	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
575540006569	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
575540006570	catalytic residues [active]
575540006571	catalytic nucleophile [active]
575540006572	Presynaptic Site I dimer interface [polypeptide binding]; other site
575540006573	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
575540006574	Synaptic Flat tetramer interface [polypeptide binding]; other site
575540006575	Synaptic Site I dimer interface [polypeptide binding]; other site
575540006576	DNA binding site [nucleotide binding]
575540006577	Recombinase; Region: Recombinase; pfam07508
575540006578	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
575540006579	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
575540006580	Protein of unknown function (DUF433); Region: DUF433; cl01030
575540006581	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
575540006582	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
575540006583	catalytic residues [active]
575540006584	catalytic nucleophile [active]
575540006585	Recombinase; Region: Recombinase; pfam07508
575540006586	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
575540006587	Recombinase; Region: Recombinase; pfam07508
575540006588	RHS Repeat; Region: RHS_repeat; cl11982
575540006589	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
575540006590	RHS Repeat; Region: RHS_repeat; cl11982
575540006591	RHS Repeat; Region: RHS_repeat; cl11982
575540006592	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
575540006593	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
575540006594	protein-splicing catalytic site; other site
575540006595	thioester formation/cholesterol transfer; other site
575540006596	Pretoxin HINT domain; Region: PT-HINT; pfam07591
575540006597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006598	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
575540006599	Phage-related protein [Function unknown]; Region: COG5412
575540006600	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540006601	Phage major tail protein 2; Region: Phage_tail_2; cl11463
575540006602	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
575540006603	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
575540006604	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
575540006605	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540006606	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
575540006607	AAA domain; Region: AAA_24; pfam13479
575540006608	Protein of unknown function (DUF669); Region: DUF669; pfam05037
575540006609	Endodeoxyribonuclease RusA; Region: RusA; cl01885
575540006610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540006611	ATP binding site [chemical binding]; other site
575540006612	putative Mg++ binding site [ion binding]; other site
575540006613	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540006614	nucleotide binding region [chemical binding]; other site
575540006615	ATP-binding site [chemical binding]; other site
575540006616	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
575540006617	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
575540006618	polymerase nucleotide-binding site; other site
575540006619	DNA-binding residues [nucleotide binding]; DNA binding site
575540006620	nucleotide binding site [chemical binding]; other site
575540006621	primase nucleotide-binding site [nucleotide binding]; other site
575540006622	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
575540006623	AAA domain; Region: AAA_25; pfam13481
575540006624	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540006625	ATP binding site [chemical binding]; other site
575540006626	Walker A motif; other site
575540006627	Walker B motif; other site
575540006628	ParB-like nuclease domain; Region: ParBc; cl02129
575540006629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006630	TIR domain; Region: TIR_2; cl15770
575540006631	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
575540006632	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
575540006633	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
575540006634	catalytic residues [active]
575540006635	catalytic nucleophile [active]
575540006636	Presynaptic Site I dimer interface [polypeptide binding]; other site
575540006637	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
575540006638	Synaptic Flat tetramer interface [polypeptide binding]; other site
575540006639	Synaptic Site I dimer interface [polypeptide binding]; other site
575540006640	DNA binding site [nucleotide binding]
575540006641	Recombinase; Region: Recombinase; pfam07508
575540006642	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
575540006643	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
575540006644	Right handed beta helix region; Region: Beta_helix; pfam13229
575540006645	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540006646	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540006647	DNA binding residues [nucleotide binding]
575540006648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540006649	Response regulator receiver domain; Region: Response_reg; pfam00072
575540006650	active site
575540006651	phosphorylation site [posttranslational modification]
575540006652	intermolecular recognition site; other site
575540006653	dimerization interface [polypeptide binding]; other site
575540006654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
575540006655	Uncharacterized conserved protein [Function unknown]; Region: COG1543
575540006656	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
575540006657	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
575540006658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006659	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
575540006660	ECF sigma factor; Region: Sigma70_ECF; pfam07638
575540006661	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
575540006662	putative active site [active]
575540006663	dimerization interface [polypeptide binding]; other site
575540006664	putative tRNAtyr binding site [nucleotide binding]; other site
575540006665	glycerol kinase; Provisional; Region: glpK; PRK00047
575540006666	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
575540006667	N- and C-terminal domain interface [polypeptide binding]; other site
575540006668	active site
575540006669	MgATP binding site [chemical binding]; other site
575540006670	catalytic site [active]
575540006671	metal binding site [ion binding]; metal-binding site
575540006672	glycerol binding site [chemical binding]; other site
575540006673	homotetramer interface [polypeptide binding]; other site
575540006674	homodimer interface [polypeptide binding]; other site
575540006675	FBP binding site [chemical binding]; other site
575540006676	protein IIAGlc interface [polypeptide binding]; other site
575540006677	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540006678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006679	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
575540006680	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540006681	ApbE family; Region: ApbE; cl00643
575540006682	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
575540006683	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
575540006684	homopentamer interface [polypeptide binding]; other site
575540006685	active site
575540006686	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
575540006687	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
575540006688	Ligand binding site; other site
575540006689	Putative Catalytic site; other site
575540006690	DXD motif; other site
575540006691	threonine synthase; Validated; Region: PRK06260
575540006692	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
575540006693	homodimer interface [polypeptide binding]; other site
575540006694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540006695	catalytic residue [active]
575540006696	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
575540006697	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540006698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540006699	active site
575540006700	phosphorylation site [posttranslational modification]
575540006701	intermolecular recognition site; other site
575540006702	dimerization interface [polypeptide binding]; other site
575540006703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540006704	Walker A motif; other site
575540006705	ATP binding site [chemical binding]; other site
575540006706	Walker B motif; other site
575540006707	arginine finger; other site
575540006708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
575540006709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540006710	dimer interface [polypeptide binding]; other site
575540006711	phosphorylation site [posttranslational modification]
575540006712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540006713	ATP binding site [chemical binding]; other site
575540006714	Mg2+ binding site [ion binding]; other site
575540006715	G-X-G motif; other site
575540006716	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540006717	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
575540006718	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540006719	putative active site [active]
575540006720	metal binding site [ion binding]; metal-binding site
575540006721	homodimer binding site [polypeptide binding]; other site
575540006722	phosphodiesterase; Provisional; Region: PRK12704
575540006723	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540006724	potassium/proton antiporter; Reviewed; Region: PRK05326
575540006725	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
575540006726	Transporter associated domain; Region: CorC_HlyC; cl08393
575540006727	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
575540006728	Fusaric acid resistance protein family; Region: FUSC; pfam04632
575540006729	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
575540006730	active site
575540006731	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
575540006732	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
575540006733	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
575540006734	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540006735	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
575540006736	substrate binding site [chemical binding]; other site
575540006737	ATP binding site [chemical binding]; other site
575540006738	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
575540006739	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
575540006740	HIGH motif; other site
575540006741	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
575540006742	active site
575540006743	KMSKS motif; other site
575540006744	Trm112p-like protein; Region: Trm112p; cl01066
575540006745	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006746	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
575540006747	substrate binding pocket [chemical binding]; other site
575540006748	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
575540006749	active site
575540006750	Helix-turn-helix domains; Region: HTH; cl00088
575540006751	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
575540006752	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
575540006753	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540006754	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540006755	Catalytic site [active]
575540006756	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
575540006757	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
575540006758	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540006759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006760	Sulfatase; Region: Sulfatase; cl10460
575540006761	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
575540006762	Cytochrome c; Region: Cytochrom_C; cl11414
575540006763	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540006764	structural tetrad; other site
575540006765	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
575540006766	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
575540006767	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540006768	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540006769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540006770	PAS domain; Region: PAS_9; pfam13426
575540006771	putative active site [active]
575540006772	heme pocket [chemical binding]; other site
575540006773	PAS domain; Region: PAS_9; pfam13426
575540006774	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540006775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006776	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
575540006777	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
575540006778	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540006779	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540006780	catalytic residue [active]
575540006781	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
575540006782	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540006783	phosphopeptide binding site; other site
575540006784	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540006785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540006786	Walker A motif; other site
575540006787	ATP binding site [chemical binding]; other site
575540006788	Walker B motif; other site
575540006789	arginine finger; other site
575540006790	Tetratricopeptide repeat; Region: TPR_10; pfam13374
575540006791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006792	TPR motif; other site
575540006793	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540006794	binding surface
575540006795	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540006796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540006797	binding surface
575540006798	TPR motif; other site
575540006799	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540006800	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540006801	translocon at the inner envelope of chloroplast subunit 62; Provisional; Region: PLN03209
575540006802	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540006803	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
575540006804	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
575540006805	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540006806	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
575540006807	amphipathic channel; other site
575540006808	Asn-Pro-Ala signature motifs; other site
575540006809	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540006810	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
575540006811	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540006812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540006813	CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113
575540006814	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
575540006815	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
575540006816	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
575540006817	dihydropteroate synthase-related protein; Region: TIGR00284
575540006818	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
575540006819	substrate binding pocket [chemical binding]; other site
575540006820	dimer interface [polypeptide binding]; other site
575540006821	inhibitor binding site; inhibition site
575540006822	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
575540006823	Flavin Reductases; Region: FlaRed; cl00801
575540006824	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540006825	heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
575540006826	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540006827	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
575540006828	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540006829	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
575540006830	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
575540006831	CHC2 zinc finger; Region: zf-CHC2; cl15369
575540006832	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
575540006833	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
575540006834	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
575540006835	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
575540006836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006837	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
575540006838	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
575540006839	active site
575540006840	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540006841	Sulfatase; Region: Sulfatase; cl10460
575540006842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540006843	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
575540006844	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540006845	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
575540006846	active site
575540006847	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
575540006848	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540006849	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540006850	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540006851	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540006852	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540006853	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
575540006854	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
575540006855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006856	oligomerization interface [polypeptide binding]; other site
575540006857	active site
575540006858	NAD+ binding site [chemical binding]; other site
575540006859	Membrane transport protein; Region: Mem_trans; cl09117
575540006860	Low molecular weight phosphatase family; Region: LMWPc; cl00105
575540006861	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540006862	Predicted permease; Region: DUF318; pfam03773
575540006863	Predicted permease; Region: DUF318; pfam03773
575540006864	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
575540006865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006866	Methyltransferase domain; Region: Methyltransf_31; pfam13847
575540006867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540006868	S-adenosylmethionine binding site [chemical binding]; other site
575540006869	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540006870	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540006871	dimerization interface [polypeptide binding]; other site
575540006872	putative DNA binding site [nucleotide binding]; other site
575540006873	putative Zn2+ binding site [ion binding]; other site
575540006874	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
575540006875	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
575540006876	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
575540006877	active site
575540006878	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
575540006879	dephospho-CoA kinase; Region: TIGR00152
575540006880	CoA-binding site [chemical binding]; other site
575540006881	ATP-binding [chemical binding]; other site
575540006882	transcription termination factor Rho; Provisional; Region: rho; PRK09376
575540006883	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
575540006884	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
575540006885	RNA binding site [nucleotide binding]; other site
575540006886	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
575540006887	multimer interface [polypeptide binding]; other site
575540006888	Walker A motif; other site
575540006889	ATP binding site [chemical binding]; other site
575540006890	Walker B motif; other site
575540006891	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
575540006892	folate binding site [chemical binding]; other site
575540006893	NADP+ binding site [chemical binding]; other site
575540006894	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
575540006895	mce related protein; Region: MCE; pfam02470
575540006896	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
575540006897	putative RNA binding site [nucleotide binding]; other site
575540006898	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
575540006899	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
575540006900	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
575540006901	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540006902	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540006903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540006904	active site
575540006905	phosphorylation site [posttranslational modification]
575540006906	intermolecular recognition site; other site
575540006907	dimerization interface [polypeptide binding]; other site
575540006908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540006909	Walker A motif; other site
575540006910	ATP binding site [chemical binding]; other site
575540006911	Walker B motif; other site
575540006912	arginine finger; other site
575540006913	Helix-turn-helix domains; Region: HTH; cl00088
575540006914	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
575540006915	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
575540006916	active site
575540006917	ADP/pyrophosphate binding site [chemical binding]; other site
575540006918	dimerization interface [polypeptide binding]; other site
575540006919	allosteric effector site; other site
575540006920	fructose-1,6-bisphosphate binding site; other site
575540006921	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
575540006922	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
575540006923	PYR/PP interface [polypeptide binding]; other site
575540006924	dimer interface [polypeptide binding]; other site
575540006925	TPP binding site [chemical binding]; other site
575540006926	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
575540006927	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
575540006928	TPP-binding site [chemical binding]; other site
575540006929	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
575540006930	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540006931	Walker A/P-loop; other site
575540006932	ATP binding site [chemical binding]; other site
575540006933	Q-loop/lid; other site
575540006934	ABC transporter signature motif; other site
575540006935	Walker B; other site
575540006936	D-loop; other site
575540006937	H-loop/switch region; other site
575540006938	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
575540006939	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
575540006940	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
575540006941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
575540006942	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
575540006943	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
575540006944	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
575540006945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540006946	active site
575540006947	metal binding site [ion binding]; metal-binding site
575540006948	homotetramer interface [polypeptide binding]; other site
575540006949	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540006950	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540006951	GatB domain; Region: GatB_Yqey; cl11497
575540006952	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
575540006953	metal binding site 2 [ion binding]; metal-binding site
575540006954	putative DNA binding helix; other site
575540006955	metal binding site 1 [ion binding]; metal-binding site
575540006956	dimer interface [polypeptide binding]; other site
575540006957	structural Zn2+ binding site [ion binding]; other site
575540006958	fumarate hydratase; Reviewed; Region: fumC; PRK00485
575540006959	Class II fumarases; Region: Fumarase_classII; cd01362
575540006960	active site
575540006961	tetramer interface [polypeptide binding]; other site
575540006962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540006963	S-adenosylmethionine binding site [chemical binding]; other site
575540006964	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
575540006965	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540006966	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540006967	active site
575540006968	metal binding site [ion binding]; metal-binding site
575540006969	membrane protein insertase; Provisional; Region: PRK01318
575540006970	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
575540006971	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540006972	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
575540006973	intracellular protease, PfpI family; Region: PfpI; TIGR01382
575540006974	proposed catalytic triad [active]
575540006975	conserved cys residue [active]
575540006976	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540006977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540006978	NAD(P) binding site [chemical binding]; other site
575540006979	active site
575540006980	transaldolase-like protein; Provisional; Region: PTZ00411
575540006981	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
575540006982	active site
575540006983	dimer interface [polypeptide binding]; other site
575540006984	catalytic residue [active]
575540006985	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
575540006986	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
575540006987	active site
575540006988	dimer interface [polypeptide binding]; other site
575540006989	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
575540006990	dimer interface [polypeptide binding]; other site
575540006991	active site
575540006992	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
575540006993	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540006994	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540006995	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540006996	C-terminal peptidase (prc); Region: prc; TIGR00225
575540006997	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540006998	protein binding site [polypeptide binding]; other site
575540006999	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
575540007000	Catalytic dyad [active]
575540007001	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
575540007002	C-terminal peptidase (prc); Region: prc; TIGR00225
575540007003	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540007004	protein binding site [polypeptide binding]; other site
575540007005	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
575540007006	Catalytic dyad [active]
575540007007	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
575540007008	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540007009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
575540007010	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540007011	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007012	G2 box; other site
575540007013	Switch I region; other site
575540007014	G3 box; other site
575540007015	Switch II region; other site
575540007016	GTP/Mg2+ binding site [chemical binding]; other site
575540007017	G4 box; other site
575540007018	G5 box; other site
575540007019	Ribosome receptor lysine/proline rich region; Region: Rib_recp_KP_reg; pfam05104
575540007020	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
575540007021	MoaE interaction surface [polypeptide binding]; other site
575540007022	MoeB interaction surface [polypeptide binding]; other site
575540007023	thiocarboxylated glycine; other site
575540007024	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
575540007025	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540007026	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
575540007027	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
575540007028	dimer interface [polypeptide binding]; other site
575540007029	catalytic residue [active]
575540007030	metal binding site [ion binding]; metal-binding site
575540007031	Response regulator receiver domain; Region: Response_reg; pfam00072
575540007032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007033	active site
575540007034	phosphorylation site [posttranslational modification]
575540007035	intermolecular recognition site; other site
575540007036	dimerization interface [polypeptide binding]; other site
575540007037	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
575540007038	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
575540007039	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
575540007040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540007041	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540007042	anti sigma factor interaction site; other site
575540007043	regulatory phosphorylation site [posttranslational modification]; other site
575540007044	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
575540007045	ParB-like nuclease domain; Region: ParBc; cl02129
575540007046	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
575540007047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007048	NAD(P) binding site [chemical binding]; other site
575540007049	active site
575540007050	Rrf2 family protein; Region: rrf2_super; TIGR00738
575540007051	Helix-turn-helix domains; Region: HTH; cl00088
575540007052	acetyl-CoA synthetase; Provisional; Region: PRK00174
575540007053	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
575540007054	AMP-binding enzyme; Region: AMP-binding; cl15778
575540007055	AMP-binding enzyme; Region: AMP-binding; cl15778
575540007056	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540007057	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540007058	catalytic residues [active]
575540007059	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540007060	active site
575540007061	catalytic residues [active]
575540007062	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
575540007063	active site
575540007064	Zn binding site [ion binding]; other site
575540007065	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
575540007066	active site
575540007067	Zn binding site [ion binding]; other site
575540007068	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
575540007069	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
575540007070	chorismate binding enzyme; Region: Chorismate_bind; cl10555
575540007071	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540007072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007073	binding surface
575540007074	TPR motif; other site
575540007075	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540007076	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540007077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007078	binding surface
575540007079	TPR motif; other site
575540007080	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540007081	conserved cys residue [active]
575540007082	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
575540007083	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
575540007084	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
575540007085	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
575540007086	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
575540007087	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
575540007088	molybdopterin cofactor binding site; other site
575540007089	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540007090	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
575540007091	putative active site [active]
575540007092	putative metal binding site [ion binding]; other site
575540007093	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540007094	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
575540007095	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540007096	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
575540007097	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
575540007098	active site
575540007099	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
575540007100	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
575540007101	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
575540007102	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
575540007103	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
575540007104	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
575540007105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540007106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540007107	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540007108	OPT oligopeptide transporter protein; Region: OPT; cl14607
575540007109	OPT oligopeptide transporter protein; Region: OPT; cl14607
575540007110	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
575540007111	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
575540007112	2-isopropylmalate synthase; Validated; Region: PRK00915
575540007113	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
575540007114	active site
575540007115	catalytic residues [active]
575540007116	metal binding site [ion binding]; metal-binding site
575540007117	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
575540007118	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
575540007119	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
575540007120	putative dimer interface [polypeptide binding]; other site
575540007121	[2Fe-2S] cluster binding site [ion binding]; other site
575540007122	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
575540007123	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
575540007124	SLBB domain; Region: SLBB; pfam10531
575540007125	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
575540007126	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
575540007127	dimer interface [polypeptide binding]; other site
575540007128	ADP-ribose binding site [chemical binding]; other site
575540007129	active site
575540007130	nudix motif; other site
575540007131	metal binding site [ion binding]; metal-binding site
575540007132	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
575540007133	Ligand Binding Site [chemical binding]; other site
575540007134	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
575540007135	homodimer interface [polypeptide binding]; other site
575540007136	substrate-cofactor binding pocket; other site
575540007137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540007138	catalytic residue [active]
575540007139	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540007140	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540007141	Walker A/P-loop; other site
575540007142	ATP binding site [chemical binding]; other site
575540007143	Q-loop/lid; other site
575540007144	ABC transporter signature motif; other site
575540007145	Walker B; other site
575540007146	D-loop; other site
575540007147	H-loop/switch region; other site
575540007148	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
575540007149	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540007150	FtsX-like permease family; Region: FtsX; cl15850
575540007151	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
575540007152	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
575540007153	dimer interface [polypeptide binding]; other site
575540007154	putative anticodon binding site; other site
575540007155	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
575540007156	motif 1; other site
575540007157	active site
575540007158	motif 2; other site
575540007159	motif 3; other site
575540007160	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540007161	Cytochrome c; Region: Cytochrom_C; cl11414
575540007162	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
575540007163	putative catalytic site [active]
575540007164	putative metal binding site [ion binding]; other site
575540007165	putative phosphate binding site [ion binding]; other site
575540007166	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
575540007167	Calx-beta domain; Region: Calx-beta; cl02522
575540007168	Calx-beta domain; Region: Calx-beta; cl02522
575540007169	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
575540007170	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
575540007171	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
575540007172	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
575540007173	lipoyl attachment site [posttranslational modification]; other site
575540007174	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
575540007175	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
575540007176	tetramer interface [polypeptide binding]; other site
575540007177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540007178	catalytic residue [active]
575540007179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007180	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
575540007181	proposed catalytic triad [active]
575540007182	active site nucleophile [active]
575540007183	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
575540007184	proposed catalytic triad [active]
575540007185	active site nucleophile [active]
575540007186	seryl-tRNA synthetase; Provisional; Region: PRK05431
575540007187	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
575540007188	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
575540007189	dimer interface [polypeptide binding]; other site
575540007190	active site
575540007191	motif 1; other site
575540007192	motif 2; other site
575540007193	motif 3; other site
575540007194	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
575540007195	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
575540007196	metal binding site [ion binding]; metal-binding site
575540007197	putative dimer interface [polypeptide binding]; other site
575540007198	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
575540007199	ATP binding site [chemical binding]; other site
575540007200	substrate binding site [chemical binding]; other site
575540007201	primosome assembly protein PriA; Validated; Region: PRK05580
575540007202	primosome assembly protein PriA; Validated; Region: PRK05580
575540007203	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540007204	ATP binding site [chemical binding]; other site
575540007205	putative Mg++ binding site [ion binding]; other site
575540007206	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540007207	ATP-binding site [chemical binding]; other site
575540007208	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
575540007209	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
575540007210	active site
575540007211	(T/H)XGH motif; other site
575540007212	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
575540007213	DNA binding site [nucleotide binding]
575540007214	active site
575540007215	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
575540007216	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
575540007217	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
575540007218	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
575540007219	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540007220	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
575540007221	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
575540007222	active site residue [active]
575540007223	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
575540007224	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
575540007225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
575540007226	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
575540007227	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540007228	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540007229	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540007230	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540007231	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
575540007232	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
575540007233	active site
575540007234	HIGH motif; other site
575540007235	KMSKS motif; other site
575540007236	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
575540007237	tRNA binding surface [nucleotide binding]; other site
575540007238	anticodon binding site; other site
575540007239	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540007240	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007241	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
575540007242	NAD(P) binding site [chemical binding]; other site
575540007243	active site
575540007244	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
575540007245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540007246	S-adenosylmethionine binding site [chemical binding]; other site
575540007247	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540007248	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540007249	active site
575540007250	ATP binding site [chemical binding]; other site
575540007251	substrate binding site [chemical binding]; other site
575540007252	activation loop (A-loop); other site
575540007253	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
575540007254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007255	TPR motif; other site
575540007256	binding surface
575540007257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007258	binding surface
575540007259	TPR motif; other site
575540007260	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540007261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007262	binding surface
575540007263	TPR motif; other site
575540007264	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540007265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007266	TPR motif; other site
575540007267	TPR repeat; Region: TPR_11; pfam13414
575540007268	binding surface
575540007269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540007270	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
575540007271	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540007272	ATP-dependent DNA ligase; Validated; Region: PRK09247
575540007273	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
575540007274	active site
575540007275	DNA binding site [nucleotide binding]
575540007276	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
575540007277	DNA binding site [nucleotide binding]
575540007278	Quinolinate synthetase A protein; Region: NadA; cl00420
575540007279	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
575540007280	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
575540007281	putative active site [active]
575540007282	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
575540007283	nucleotide binding site/active site [active]
575540007284	HIT family signature motif; other site
575540007285	catalytic residue [active]
575540007286	elongation factor G; Reviewed; Region: PRK00007
575540007287	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
575540007288	G1 box; other site
575540007289	putative GEF interaction site [polypeptide binding]; other site
575540007290	GTP/Mg2+ binding site [chemical binding]; other site
575540007291	Switch I region; other site
575540007292	G2 box; other site
575540007293	G3 box; other site
575540007294	Switch II region; other site
575540007295	G4 box; other site
575540007296	G5 box; other site
575540007297	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
575540007298	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
575540007299	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
575540007300	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
575540007301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007302	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
575540007303	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
575540007304	Sulfatase; Region: Sulfatase; cl10460
575540007305	choline-sulfatase; Region: chol_sulfatase; TIGR03417
575540007306	PrkA AAA domain; Region: AAA_PrkA; smart00763
575540007307	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007308	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
575540007309	Uncharacterized conserved protein [Function unknown]; Region: COG2718
575540007310	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540007311	SpoVR like protein; Region: SpoVR; pfam04293
575540007312	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
575540007313	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
575540007314	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
575540007315	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
575540007316	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007317	Walker A/P-loop; other site
575540007318	ATP binding site [chemical binding]; other site
575540007319	Q-loop/lid; other site
575540007320	ABC transporter signature motif; other site
575540007321	Walker B; other site
575540007322	D-loop; other site
575540007323	H-loop/switch region; other site
575540007324	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
575540007325	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
575540007326	substrate binding site [chemical binding]; other site
575540007327	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
575540007328	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
575540007329	substrate binding site [chemical binding]; other site
575540007330	ligand binding site [chemical binding]; other site
575540007331	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540007332	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540007333	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540007334	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
575540007335	NHL repeat; Region: NHL; pfam01436
575540007336	NHL repeat; Region: NHL; pfam01436
575540007337	NHL repeat; Region: NHL; pfam01436
575540007338	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540007339	metal ion-dependent adhesion site (MIDAS); other site
575540007340	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540007341	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540007342	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540007343	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540007344	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540007345	Aerotolerance regulator N-terminal; Region: BatA; cl06567
575540007346	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540007347	metal ion-dependent adhesion site (MIDAS); other site
575540007348	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
575540007349	interface (dimer of trimers) [polypeptide binding]; other site
575540007350	Substrate-binding/catalytic site; other site
575540007351	Zn-binding sites [ion binding]; other site
575540007352	Family description; Region: VCBS; pfam13517
575540007353	Family description; Region: VCBS; pfam13517
575540007354	Family description; Region: VCBS; pfam13517
575540007355	putative acyltransferase; Provisional; Region: PRK05790
575540007356	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
575540007357	dimer interface [polypeptide binding]; other site
575540007358	active site
575540007359	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
575540007360	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
575540007361	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
575540007362	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
575540007363	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
575540007364	putative active site [active]
575540007365	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
575540007366	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
575540007367	RNA binding surface [nucleotide binding]; other site
575540007368	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
575540007369	active site
575540007370	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
575540007371	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
575540007372	FAD binding pocket [chemical binding]; other site
575540007373	FAD binding motif [chemical binding]; other site
575540007374	phosphate binding motif [ion binding]; other site
575540007375	beta-alpha-beta structure motif; other site
575540007376	NAD binding pocket [chemical binding]; other site
575540007377	Iron coordination center [ion binding]; other site
575540007378	large tegument protein UL36; Provisional; Region: PHA03247
575540007379	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
575540007380	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
575540007381	putative hydrophobic ligand binding site [chemical binding]; other site
575540007382	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540007383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007384	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540007385	active site
575540007386	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
575540007387	PhoU domain; Region: PhoU; pfam01895
575540007388	PhoU domain; Region: PhoU; pfam01895
575540007389	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
575540007390	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
575540007391	MG2 domain; Region: A2M_N; pfam01835
575540007392	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
575540007393	Alpha-2-macroglobulin family; Region: A2M; pfam00207
575540007394	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
575540007395	surface patch; other site
575540007396	thioester region; other site
575540007397	specificity defining residues; other site
575540007398	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
575540007399	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
575540007400	homotrimer interaction site [polypeptide binding]; other site
575540007401	putative active site [active]
575540007402	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
575540007403	classical (c) SDRs; Region: SDR_c; cd05233
575540007404	NAD(P) binding site [chemical binding]; other site
575540007405	active site
575540007406	hypothetical protein; Provisional; Region: PRK02947
575540007407	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
575540007408	putative active site [active]
575540007409	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541
575540007410	active site
575540007411	hydrophilic channel; other site
575540007412	dimerization interface [polypeptide binding]; other site
575540007413	catalytic residues [active]
575540007414	active site lid [active]
575540007415	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
575540007416	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
575540007417	HEAT repeats; Region: HEAT_2; pfam13646
575540007418	DNA-K related protein; Region: DUF3731; pfam12531
575540007419	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
575540007420	Cytochrome c; Region: Cytochrom_C; cl11414
575540007421	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540007422	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
575540007423	FAD binding domain; Region: FAD_binding_4; pfam01565
575540007424	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
575540007425	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540007426	structural tetrad; other site
575540007427	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540007428	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540007429	Family description; Region: VCBS; pfam13517
575540007430	Family description; Region: VCBS; pfam13517
575540007431	Family description; Region: VCBS; pfam13517
575540007432	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
575540007433	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
575540007434	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
575540007435	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
575540007436	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
575540007437	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540007438	nucleotide binding region [chemical binding]; other site
575540007439	ATP-binding site [chemical binding]; other site
575540007440	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
575540007441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
575540007442	SEC-C motif; Region: SEC-C; pfam02810
575540007443	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540007444	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540007445	active site
575540007446	ATP binding site [chemical binding]; other site
575540007447	substrate binding site [chemical binding]; other site
575540007448	activation loop (A-loop); other site
575540007449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007450	TPR motif; other site
575540007451	binding surface
575540007452	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540007453	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
575540007454	DNA binding residues [nucleotide binding]
575540007455	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
575540007456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007457	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
575540007458	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
575540007459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007460	excinuclease ABC subunit B; Provisional; Region: PRK05298
575540007461	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540007462	ATP binding site [chemical binding]; other site
575540007463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540007464	nucleotide binding region [chemical binding]; other site
575540007465	ATP-binding site [chemical binding]; other site
575540007466	Ultra-violet resistance protein B; Region: UvrB; pfam12344
575540007467	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
575540007468	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
575540007469	dimerization interface [polypeptide binding]; other site
575540007470	active site
575540007471	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
575540007472	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
575540007473	UbiA prenyltransferase family; Region: UbiA; cl00337
575540007474	HEAT repeats; Region: HEAT_2; pfam13646
575540007475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007476	TPR motif; other site
575540007477	TPR repeat; Region: TPR_11; pfam13414
575540007478	binding surface
575540007479	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
575540007480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540007481	ATP binding site [chemical binding]; other site
575540007482	putative Mg++ binding site [ion binding]; other site
575540007483	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007484	Helicase associated domain (HA2); Region: HA2; cl04503
575540007485	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
575540007486	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
575540007487	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
575540007488	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
575540007489	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
575540007490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540007491	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
575540007492	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
575540007493	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
575540007494	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540007495	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540007496	active site
575540007497	metal binding site [ion binding]; metal-binding site
575540007498	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
575540007499	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
575540007500	substrate binding site [chemical binding]; other site
575540007501	active site
575540007502	catalytic residues [active]
575540007503	heterodimer interface [polypeptide binding]; other site
575540007504	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
575540007505	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
575540007506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540007507	catalytic residue [active]
575540007508	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
575540007509	putative ligand binding pocket/active site [active]
575540007510	putative metal binding site [ion binding]; other site
575540007511	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540007512	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
575540007513	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540007514	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540007515	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540007516	active site
575540007517	ATP binding site [chemical binding]; other site
575540007518	substrate binding site [chemical binding]; other site
575540007519	activation loop (A-loop); other site
575540007520	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540007521	active site
575540007522	large tegument protein UL36; Provisional; Region: PHA03247
575540007523	Uncharacterized conserved protein [Function unknown]; Region: COG5276
575540007524	LVIVD repeat; Region: LVIVD; pfam08309
575540007525	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540007526	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540007527	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
575540007528	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
575540007529	GTP binding site; other site
575540007530	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
575540007531	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
575540007532	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540007533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007534	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
575540007535	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540007536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007537	active site
575540007538	phosphorylation site [posttranslational modification]
575540007539	intermolecular recognition site; other site
575540007540	dimerization interface [polypeptide binding]; other site
575540007541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540007542	Walker A motif; other site
575540007543	ATP binding site [chemical binding]; other site
575540007544	Walker B motif; other site
575540007545	arginine finger; other site
575540007546	Helix-turn-helix domains; Region: HTH; cl00088
575540007547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
575540007548	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
575540007549	dimerization interface [polypeptide binding]; other site
575540007550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
575540007551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007552	ATP binding site [chemical binding]; other site
575540007553	Mg2+ binding site [ion binding]; other site
575540007554	G-X-G motif; other site
575540007555	magnesium-transporting ATPase; Provisional; Region: PRK15122
575540007556	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
575540007557	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
575540007558	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
575540007559	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540007560	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
575540007561	magnesium transport protein MgtC; Provisional; Region: PRK15385
575540007562	MgtC family; Region: MgtC; pfam02308
575540007563	pyruvate phosphate dikinase; Provisional; Region: PRK09279
575540007564	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
575540007565	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
575540007566	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540007567	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
575540007568	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
575540007569	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
575540007570	Walker A motif; other site
575540007571	ATP binding site [chemical binding]; other site
575540007572	Walker B motif; other site
575540007573	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
575540007574	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007575	Walker A motif; other site
575540007576	ATP binding site [chemical binding]; other site
575540007577	Walker B motif; other site
575540007578	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
575540007579	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
575540007580	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
575540007581	Walker A motif; other site
575540007582	ATP binding site [chemical binding]; other site
575540007583	Walker B motif; other site
575540007584	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540007585	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
575540007586	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540007587	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540007588	Cytochrome c; Region: Cytochrom_C; cl11414
575540007589	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
575540007590	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
575540007591	active site
575540007592	catalytic residues [active]
575540007593	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
575540007594	isocitrate dehydrogenase; Validated; Region: PRK09222
575540007595	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
575540007596	heat shock protein 90; Provisional; Region: PRK05218
575540007597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540007598	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
575540007599	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
575540007600	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
575540007601	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
575540007602	ring oligomerisation interface [polypeptide binding]; other site
575540007603	ATP/Mg binding site [chemical binding]; other site
575540007604	stacking interactions; other site
575540007605	hinge regions; other site
575540007606	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
575540007607	oligomerisation interface [polypeptide binding]; other site
575540007608	mobile loop; other site
575540007609	roof hairpin; other site
575540007610	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540007611	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007612	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007613	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
575540007614	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540007615	putative active site [active]
575540007616	putative metal binding site [ion binding]; other site
575540007617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540007618	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
575540007619	ATP binding site [chemical binding]; other site
575540007620	putative Mg++ binding site [ion binding]; other site
575540007621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540007622	nucleotide binding region [chemical binding]; other site
575540007623	ATP-binding site [chemical binding]; other site
575540007624	DEAD/H associated; Region: DEAD_assoc; pfam08494
575540007625	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007626	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
575540007627	NAD(P) binding site [chemical binding]; other site
575540007628	active site
575540007629	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
575540007630	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
575540007631	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
575540007632	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
575540007633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540007634	catalytic residue [active]
575540007635	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
575540007636	intramembrane serine protease GlpG; Provisional; Region: PRK10907
575540007637	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
575540007638	Rhomboid family; Region: Rhomboid; cl11446
575540007639	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
575540007640	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
575540007641	dimerization interface [polypeptide binding]; other site
575540007642	active site
575540007643	metal binding site [ion binding]; metal-binding site
575540007644	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
575540007645	dsRNA binding site [nucleotide binding]; other site
575540007646	elongation factor P; Validated; Region: PRK00529
575540007647	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
575540007648	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
575540007649	RNA binding site [nucleotide binding]; other site
575540007650	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
575540007651	RNA binding site [nucleotide binding]; other site
575540007652	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
575540007653	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
575540007654	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540007655	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540007656	DNA binding residues [nucleotide binding]
575540007657	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
575540007658	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
575540007659	minor groove reading motif; other site
575540007660	helix-hairpin-helix signature motif; other site
575540007661	active site
575540007662	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540007663	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540007664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007665	binding surface
575540007666	TPR motif; other site
575540007667	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540007668	GMP synthase; Reviewed; Region: guaA; PRK00074
575540007669	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
575540007670	AMP/PPi binding site [chemical binding]; other site
575540007671	candidate oxyanion hole; other site
575540007672	catalytic triad [active]
575540007673	potential glutamine specificity residues [chemical binding]; other site
575540007674	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
575540007675	ATP Binding subdomain [chemical binding]; other site
575540007676	Dimerization subdomain; other site
575540007677	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
575540007678	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007679	Family description; Region: UvrD_C_2; cl15862
575540007680	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
575540007681	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
575540007682	catalytic residue [active]
575540007683	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
575540007684	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821
575540007685	dimer interface [polypeptide binding]; other site
575540007686	active site
575540007687	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
575540007688	substrate binding site [chemical binding]; other site
575540007689	catalytic residue [active]
575540007690	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
575540007691	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
575540007692	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
575540007693	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
575540007694	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
575540007695	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
575540007696	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
575540007697	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
575540007698	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540007699	phosphopeptide binding site; other site
575540007700	GAF domain; Region: GAF; cl15785
575540007701	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
575540007702	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
575540007703	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540007704	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007705	protein binding site [polypeptide binding]; other site
575540007706	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007707	protein binding site [polypeptide binding]; other site
575540007708	replicative DNA helicase; Region: DnaB; TIGR00665
575540007709	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
575540007710	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
575540007711	Walker A motif; other site
575540007712	ATP binding site [chemical binding]; other site
575540007713	Walker B motif; other site
575540007714	DNA binding loops [nucleotide binding]
575540007715	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
575540007716	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
575540007717	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
575540007718	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
575540007719	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
575540007720	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
575540007721	putative catalytic site [active]
575540007722	putative metal binding site [ion binding]; other site
575540007723	putative phosphate binding site [ion binding]; other site
575540007724	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540007725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540007726	binding surface
575540007727	TPR motif; other site
575540007728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540007729	binding surface
575540007730	TPR motif; other site
575540007731	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
575540007732	TIGR03440 family protein; Region: unchr_TIGR03440
575540007733	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540007734	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
575540007735	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
575540007736	tetramerization interface [polypeptide binding]; other site
575540007737	NAD(P) binding site [chemical binding]; other site
575540007738	catalytic residues [active]
575540007739	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
575540007740	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
575540007741	Protein of unknown function, DUF480; Region: DUF480; cl01209
575540007742	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
575540007743	dimer interface [polypeptide binding]; other site
575540007744	ssDNA binding site [nucleotide binding]; other site
575540007745	tetramer (dimer of dimers) interface [polypeptide binding]; other site
575540007746	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
575540007747	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
575540007748	putative active site [active]
575540007749	catalytic residue [active]
575540007750	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
575540007751	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
575540007752	5S rRNA interface [nucleotide binding]; other site
575540007753	CTC domain interface [polypeptide binding]; other site
575540007754	L16 interface [polypeptide binding]; other site
575540007755	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
575540007756	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
575540007757	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
575540007758	Tetratricopeptide repeat; Region: TPR_6; pfam13174
575540007759	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540007760	catalytic residues [active]
575540007761	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
575540007762	GAF domain; Region: GAF; cl15785
575540007763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540007764	dimer interface [polypeptide binding]; other site
575540007765	phosphorylation site [posttranslational modification]
575540007766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007767	ATP binding site [chemical binding]; other site
575540007768	Mg2+ binding site [ion binding]; other site
575540007769	G-X-G motif; other site
575540007770	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
575540007771	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
575540007772	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
575540007773	thiamine phosphate binding site [chemical binding]; other site
575540007774	active site
575540007775	pyrophosphate binding site [ion binding]; other site
575540007776	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
575540007777	catalytic residues [active]
575540007778	dimer interface [polypeptide binding]; other site
575540007779	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540007780	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540007781	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540007782	Transmembrane secretion effector; Region: MFS_3; pfam05977
575540007783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
575540007784	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
575540007785	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
575540007786	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
575540007787	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
575540007788	Ligand Binding Site [chemical binding]; other site
575540007789	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
575540007790	PAS fold; Region: PAS_4; pfam08448
575540007791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540007792	putative active site [active]
575540007793	heme pocket [chemical binding]; other site
575540007794	PAS domain S-box; Region: sensory_box; TIGR00229
575540007795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540007796	putative active site [active]
575540007797	heme pocket [chemical binding]; other site
575540007798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540007799	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
575540007800	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540007801	dimer interface [polypeptide binding]; other site
575540007802	phosphorylation site [posttranslational modification]
575540007803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007804	ATP binding site [chemical binding]; other site
575540007805	Mg2+ binding site [ion binding]; other site
575540007806	G-X-G motif; other site
575540007807	Response regulator receiver domain; Region: Response_reg; pfam00072
575540007808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007809	active site
575540007810	phosphorylation site [posttranslational modification]
575540007811	intermolecular recognition site; other site
575540007812	dimerization interface [polypeptide binding]; other site
575540007813	Cytochrome c; Region: Cytochrom_C; cl11414
575540007814	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540007815	structural tetrad; other site
575540007816	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540007817	structural tetrad; other site
575540007818	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
575540007819	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
575540007820	inhibitor-cofactor binding pocket; inhibition site
575540007821	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540007822	catalytic residue [active]
575540007823	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540007824	structural tetrad; other site
575540007825	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540007826	structural tetrad; other site
575540007827	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540007828	structural tetrad; other site
575540007829	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
575540007830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007831	active site
575540007832	phosphorylation site [posttranslational modification]
575540007833	intermolecular recognition site; other site
575540007834	dimerization interface [polypeptide binding]; other site
575540007835	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540007836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007837	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540007838	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
575540007839	selenophosphate synthetase; Provisional; Region: PRK00943
575540007840	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
575540007841	dimerization interface [polypeptide binding]; other site
575540007842	putative ATP binding site [chemical binding]; other site
575540007843	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
575540007844	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
575540007845	Amidase; Region: Amidase; cl11426
575540007846	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
575540007847	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
575540007848	GatB domain; Region: GatB_Yqey; cl11497
575540007849	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
575540007850	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
575540007851	DNA binding site [nucleotide binding]
575540007852	Int/Topo IB signature motif; other site
575540007853	active site
575540007854	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
575540007855	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
575540007856	Transporter associated domain; Region: CorC_HlyC; cl08393
575540007857	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
575540007858	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
575540007859	active site residue [active]
575540007860	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
575540007861	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540007862	Beta-Casp domain; Region: Beta-Casp; cl12567
575540007863	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
575540007864	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
575540007865	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
575540007866	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
575540007867	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
575540007868	GAF domain; Region: GAF; cl15785
575540007869	Phytochrome region; Region: PHY; pfam00360
575540007870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540007871	dimer interface [polypeptide binding]; other site
575540007872	phosphorylation site [posttranslational modification]
575540007873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007874	ATP binding site [chemical binding]; other site
575540007875	Mg2+ binding site [ion binding]; other site
575540007876	G-X-G motif; other site
575540007877	Response regulator receiver domain; Region: Response_reg; pfam00072
575540007878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007879	active site
575540007880	phosphorylation site [posttranslational modification]
575540007881	intermolecular recognition site; other site
575540007882	dimerization interface [polypeptide binding]; other site
575540007883	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
575540007884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540007885	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540007886	Sulfatase; Region: Sulfatase; cl10460
575540007887	Sulfatase; Region: Sulfatase; cl10460
575540007888	Peptidase family M48; Region: Peptidase_M48; cl12018
575540007889	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
575540007890	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899
575540007891	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540007892	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007893	protein binding site [polypeptide binding]; other site
575540007894	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540007895	protein binding site [polypeptide binding]; other site
575540007896	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
575540007897	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540007898	FeS/SAM binding site; other site
575540007899	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540007900	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540007901	active site
575540007902	ATP binding site [chemical binding]; other site
575540007903	substrate binding site [chemical binding]; other site
575540007904	activation loop (A-loop); other site
575540007905	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540007906	TPR repeat; Region: TPR_11; pfam13414
575540007907	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540007908	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540007909	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540007910	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
575540007911	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
575540007912	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
575540007913	CAAX protease self-immunity; Region: Abi; cl00558
575540007914	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
575540007915	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540007916	Walker A/P-loop; other site
575540007917	ATP binding site [chemical binding]; other site
575540007918	Q-loop/lid; other site
575540007919	ABC transporter signature motif; other site
575540007920	Walker B; other site
575540007921	D-loop; other site
575540007922	H-loop/switch region; other site
575540007923	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
575540007924	anti sigma factor interaction site; other site
575540007925	regulatory phosphorylation site [posttranslational modification]; other site
575540007926	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
575540007927	active site
575540007928	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
575540007929	DNA binding residues [nucleotide binding]
575540007930	B12 binding domain; Region: B12-binding_2; cl03653
575540007931	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
575540007932	B12 binding site [chemical binding]; other site
575540007933	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
575540007934	Predicted esterase [General function prediction only]; Region: COG0400
575540007935	Fibronectin type III-like domain; Region: Fn3-like; cl15273
575540007936	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
575540007937	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
575540007938	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007939	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540007940	phosphopeptide binding site; other site
575540007941	GAF domain; Region: GAF_2; pfam13185
575540007942	GAF domain; Region: GAF; cl15785
575540007943	sensory histidine kinase AtoS; Provisional; Region: PRK11360
575540007944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007945	ATP binding site [chemical binding]; other site
575540007946	Mg2+ binding site [ion binding]; other site
575540007947	G-X-G motif; other site
575540007948	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540007949	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
575540007950	Protein of unknown function (DUF429); Region: DUF429; cl12046
575540007951	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
575540007952	active site
575540007953	ADP/pyrophosphate binding site [chemical binding]; other site
575540007954	allosteric effector site; other site
575540007955	dimerization interface [polypeptide binding]; other site
575540007956	fructose-1,6-bisphosphate binding site; other site
575540007957	TM2 domain; Region: TM2; cl00984
575540007958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
575540007959	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
575540007960	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
575540007961	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540007962	dimerization interface [polypeptide binding]; other site
575540007963	putative DNA binding site [nucleotide binding]; other site
575540007964	putative Zn2+ binding site [ion binding]; other site
575540007965	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
575540007966	Plant ATP synthase F0; Region: YMF19; cl07975
575540007967	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
575540007968	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
575540007969	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
575540007970	PAS domain S-box; Region: sensory_box; TIGR00229
575540007971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540007972	putative active site [active]
575540007973	heme pocket [chemical binding]; other site
575540007974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540007975	dimer interface [polypeptide binding]; other site
575540007976	phosphorylation site [posttranslational modification]
575540007977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540007978	ATP binding site [chemical binding]; other site
575540007979	Mg2+ binding site [ion binding]; other site
575540007980	G-X-G motif; other site
575540007981	Response regulator receiver domain; Region: Response_reg; pfam00072
575540007982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540007983	active site
575540007984	phosphorylation site [posttranslational modification]
575540007985	intermolecular recognition site; other site
575540007986	dimerization interface [polypeptide binding]; other site
575540007987	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
575540007988	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540007989	Metal-binding active site; metal-binding site
575540007990	hypothetical protein; Provisional; Region: PRK07208
575540007991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540007992	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
575540007993	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
575540007994	classical (c) SDRs; Region: SDR_c; cd05233
575540007995	NAD(P) binding site [chemical binding]; other site
575540007996	active site
575540007997	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
575540007998	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
575540007999	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
575540008000	Predicted GTPases [General function prediction only]; Region: COG1161
575540008001	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008002	G1 box; other site
575540008003	GTP/Mg2+ binding site [chemical binding]; other site
575540008004	G2 box; other site
575540008005	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008006	G1 box; other site
575540008007	GTP/Mg2+ binding site [chemical binding]; other site
575540008008	G2 box; other site
575540008009	Switch I region; other site
575540008010	G3 box; other site
575540008011	Switch II region; other site
575540008012	G4 box; other site
575540008013	G5 box; other site
575540008014	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
575540008015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540008016	Walker A motif; other site
575540008017	ATP binding site [chemical binding]; other site
575540008018	Walker B motif; other site
575540008019	arginine finger; other site
575540008020	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
575540008021	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
575540008022	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
575540008023	recombination protein RecR; Reviewed; Region: recR; PRK00076
575540008024	RecR protein; Region: RecR; pfam02132
575540008025	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
575540008026	putative active site [active]
575540008027	putative metal-binding site [ion binding]; other site
575540008028	tetramer interface [polypeptide binding]; other site
575540008029	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
575540008030	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
575540008031	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
575540008032	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
575540008033	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
575540008034	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
575540008035	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
575540008036	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
575540008037	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
575540008038	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
575540008039	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
575540008040	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
575540008041	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
575540008042	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
575540008043	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
575540008044	DNA binding site [nucleotide binding]
575540008045	Int/Topo IB signature motif; other site
575540008046	active site
575540008047	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540008048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540008049	active site
575540008050	phosphorylation site [posttranslational modification]
575540008051	intermolecular recognition site; other site
575540008052	dimerization interface [polypeptide binding]; other site
575540008053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540008054	Walker A motif; other site
575540008055	ATP binding site [chemical binding]; other site
575540008056	Walker B motif; other site
575540008057	arginine finger; other site
575540008058	Helix-turn-helix domains; Region: HTH; cl00088
575540008059	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540008060	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
575540008061	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540008062	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540008063	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540008064	Protein phosphatase 2C; Region: PP2C; pfam00481
575540008065	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
575540008066	active site
575540008067	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
575540008068	MoaE homodimer interface [polypeptide binding]; other site
575540008069	MoaD interaction [polypeptide binding]; other site
575540008070	active site residues [active]
575540008071	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
575540008072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540008073	FeS/SAM binding site; other site
575540008074	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
575540008075	Flagellin N-methylase; Region: FliB; cl00497
575540008076	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
575540008077	IHF dimer interface [polypeptide binding]; other site
575540008078	IHF - DNA interface [nucleotide binding]; other site
575540008079	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540008080	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
575540008081	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
575540008082	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
575540008083	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
575540008084	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
575540008085	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
575540008086	dimer interface [polypeptide binding]; other site
575540008087	substrate binding site [chemical binding]; other site
575540008088	metal binding sites [ion binding]; metal-binding site
575540008089	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
575540008090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008091	NAD(P) binding site [chemical binding]; other site
575540008092	active site
575540008093	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540008094	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008095	Plant ATP synthase F0; Region: YMF19; cl07975
575540008096	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008097	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540008098	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540008099	Walker A/P-loop; other site
575540008100	ATP binding site [chemical binding]; other site
575540008101	Q-loop/lid; other site
575540008102	ABC transporter signature motif; other site
575540008103	Walker B; other site
575540008104	D-loop; other site
575540008105	H-loop/switch region; other site
575540008106	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540008107	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
575540008108	FtsX-like permease family; Region: FtsX; cl15850
575540008109	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
575540008110	PQQ-like domain; Region: PQQ_2; pfam13360
575540008111	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008112	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
575540008113	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
575540008114	Oxygen tolerance; Region: BatD; pfam13584
575540008115	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
575540008116	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
575540008117	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
575540008118	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
575540008119	metal binding site [ion binding]; metal-binding site
575540008120	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
575540008121	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
575540008122	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
575540008123	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
575540008124	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
575540008125	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008126	Survival protein SurE; Region: SurE; cl00448
575540008127	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
575540008128	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
575540008129	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
575540008130	catalytic residues [active]
575540008131	Protein of unknown function (DUF502); Region: DUF502; cl01107
575540008132	DNA primase; Validated; Region: dnaG; PRK05667
575540008133	CHC2 zinc finger; Region: zf-CHC2; cl15369
575540008134	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
575540008135	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
575540008136	active site
575540008137	metal binding site [ion binding]; metal-binding site
575540008138	interdomain interaction site; other site
575540008139	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
575540008140	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
575540008141	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
575540008142	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540008143	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
575540008144	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540008145	DNA binding residues [nucleotide binding]
575540008146	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540008147	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
575540008148	Putative zinc ribbon domain; Region: DUF164; pfam02591
575540008149	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
575540008150	Mg++ binding site [ion binding]; other site
575540008151	putative catalytic motif [active]
575540008152	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
575540008153	Chain length determinant protein; Region: Wzz; cl15801
575540008154	Chain length determinant protein; Region: Wzz; cl15801
575540008155	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
575540008156	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008157	O-Antigen ligase; Region: Wzy_C; cl04850
575540008158	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
575540008159	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
575540008160	GDP-mannose 4,6-dehydratase; Region: PLN02653
575540008161	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
575540008162	NADP-binding site; other site
575540008163	homotetramer interface [polypeptide binding]; other site
575540008164	substrate binding site [chemical binding]; other site
575540008165	homodimer interface [polypeptide binding]; other site
575540008166	active site
575540008167	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
575540008168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540008169	D-galactonate transporter; Region: 2A0114; TIGR00893
575540008170	putative substrate translocation pore; other site
575540008171	malate dehydrogenase; Provisional; Region: PRK05442
575540008172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008173	NAD(P) binding site [chemical binding]; other site
575540008174	LDH/MDH dimer interface [polypeptide binding]; other site
575540008175	substrate binding site [chemical binding]; other site
575540008176	DHH family; Region: DHH; pfam01368
575540008177	TspO/MBR family; Region: TspO_MBR; cl01379
575540008178	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008179	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
575540008180	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
575540008181	AsmA-like C-terminal region; Region: AsmA_2; cl15864
575540008182	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
575540008183	active site
575540008184	catalytic residues [active]
575540008185	metal binding site [ion binding]; metal-binding site
575540008186	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540008187	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540008188	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
575540008189	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
575540008190	putative active site [active]
575540008191	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
575540008192	Family description; Region: VCBS; pfam13517
575540008193	Family description; Region: VCBS; pfam13517
575540008194	Family description; Region: VCBS; pfam13517
575540008195	Family description; Region: VCBS; pfam13517
575540008196	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
575540008197	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540008198	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540008199	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540008200	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
575540008201	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540008202	catalytic core [active]
575540008203	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
575540008204	Amidinotransferase; Region: Amidinotransf; cl12043
575540008205	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
575540008206	active site
575540008207	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
575540008208	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
575540008209	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
575540008210	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
575540008211	putative dimer interface [polypeptide binding]; other site
575540008212	putative anticodon binding site; other site
575540008213	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
575540008214	homodimer interface [polypeptide binding]; other site
575540008215	motif 1; other site
575540008216	motif 2; other site
575540008217	active site
575540008218	motif 3; other site
575540008219	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
575540008220	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540008221	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
575540008222	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540008223	DNA binding residues [nucleotide binding]
575540008224	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
575540008225	putative catalytic residue [active]
575540008226	CHAT domain; Region: CHAT; pfam12770
575540008227	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008228	FOG: WD40 repeat [General function prediction only]; Region: COG2319
575540008229	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
575540008230	structural tetrad; other site
575540008231	Cytochrome c; Region: Cytochrom_C; cl11414
575540008232	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540008233	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540008234	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540008235	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540008236	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008237	active site
575540008238	ATP binding site [chemical binding]; other site
575540008239	substrate binding site [chemical binding]; other site
575540008240	activation loop (A-loop); other site
575540008241	Predicted peptidase [General function prediction only]; Region: COG4099
575540008242	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540008243	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
575540008244	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
575540008245	heterodimer interface [polypeptide binding]; other site
575540008246	active site
575540008247	FMN binding site [chemical binding]; other site
575540008248	homodimer interface [polypeptide binding]; other site
575540008249	substrate binding site [chemical binding]; other site
575540008250	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
575540008251	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
575540008252	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
575540008253	O-Antigen ligase; Region: Wzy_C; cl04850
575540008254	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
575540008255	Mg++ binding site [ion binding]; other site
575540008256	putative catalytic motif [active]
575540008257	substrate binding site [chemical binding]; other site
575540008258	prolyl-tRNA synthetase; Provisional; Region: PRK09194
575540008259	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
575540008260	dimer interface [polypeptide binding]; other site
575540008261	motif 1; other site
575540008262	active site
575540008263	motif 2; other site
575540008264	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
575540008265	putative deacylase active site [active]
575540008266	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540008267	active site
575540008268	motif 3; other site
575540008269	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
575540008270	anticodon binding site; other site
575540008271	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
575540008272	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
575540008273	Substrate binding site; other site
575540008274	Mg++ binding site; other site
575540008275	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
575540008276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
575540008277	Coenzyme A binding pocket [chemical binding]; other site
575540008278	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
575540008279	[2Fe-2S] cluster binding site [ion binding]; other site
575540008280	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
575540008281	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
575540008282	active site
575540008283	catalytic tetrad [active]
575540008284	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
575540008285	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
575540008286	minor groove reading motif; other site
575540008287	helix-hairpin-helix signature motif; other site
575540008288	substrate binding pocket [chemical binding]; other site
575540008289	active site
575540008290	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
575540008291	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
575540008292	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
575540008293	homodecamer interface [polypeptide binding]; other site
575540008294	GTP cyclohydrolase I; Provisional; Region: PLN03044
575540008295	active site
575540008296	putative catalytic site residues [active]
575540008297	zinc binding site [ion binding]; other site
575540008298	GTP-CH-I/GFRP interaction surface; other site
575540008299	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
575540008300	FAD binding domain; Region: FAD_binding_4; pfam01565
575540008301	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
575540008302	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008303	ApbE family; Region: ApbE; cl00643
575540008304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008305	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540008306	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
575540008307	substrate binding site; other site
575540008308	dimer interface; other site
575540008309	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540008310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540008312	S-adenosylmethionine binding site [chemical binding]; other site
575540008313	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
575540008314	Ligand binding site; other site
575540008315	Putative Catalytic site; other site
575540008316	DXD motif; other site
575540008317	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
575540008318	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
575540008319	active site
575540008320	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540008321	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540008322	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
575540008323	active site
575540008324	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
575540008325	homodimer interface [polypeptide binding]; other site
575540008326	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
575540008327	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
575540008328	Walker A/P-loop; other site
575540008329	ATP binding site [chemical binding]; other site
575540008330	Q-loop/lid; other site
575540008331	ABC transporter signature motif; other site
575540008332	Walker B; other site
575540008333	D-loop; other site
575540008334	H-loop/switch region; other site
575540008335	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
575540008336	putative carbohydrate binding site [chemical binding]; other site
575540008337	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540008338	O-Antigen ligase; Region: Wzy_C; cl04850
575540008339	O-Antigen ligase; Region: Wzy_C; cl04850
575540008340	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
575540008341	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
575540008342	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
575540008343	Nucleotide binding site [chemical binding]; other site
575540008344	DTAP/Switch II; other site
575540008345	Switch I; other site
575540008346	Calx-beta domain; Region: Calx-beta; cl02522
575540008347	Calx-beta domain; Region: Calx-beta; cl02522
575540008348	Calx-beta domain; Region: Calx-beta; cl02522
575540008349	Calx-beta domain; Region: Calx-beta; cl02522
575540008350	Calx-beta domain; Region: Calx-beta; cl02522
575540008351	Calx-beta domain; Region: Calx-beta; cl02522
575540008352	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
575540008353	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
575540008354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540008355	nucleotide binding region [chemical binding]; other site
575540008356	ATP-binding site [chemical binding]; other site
575540008357	Uncharacterized conserved protein [Function unknown]; Region: COG3391
575540008358	Restriction endonuclease; Region: Mrr_cat; cl00516
575540008359	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
575540008360	HSP70 interaction site [polypeptide binding]; other site
575540008361	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
575540008362	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
575540008363	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
575540008364	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
575540008365	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
575540008366	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008367	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540008368	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540008369	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
575540008370	Response regulator receiver domain; Region: Response_reg; pfam00072
575540008371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540008372	active site
575540008373	phosphorylation site [posttranslational modification]
575540008374	intermolecular recognition site; other site
575540008375	dimerization interface [polypeptide binding]; other site
575540008376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
575540008377	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
575540008378	AIR carboxylase; Region: AIRC; cl00310
575540008379	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
575540008380	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540008381	Helix-turn-helix domains; Region: HTH; cl00088
575540008382	glycogen branching enzyme; Provisional; Region: PRK05402
575540008383	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
575540008384	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
575540008385	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
575540008386	active site
575540008387	catalytic site [active]
575540008388	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
575540008389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008390	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
575540008391	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
575540008392	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
575540008393	malonyl-CoA binding site [chemical binding]; other site
575540008394	dimer interface [polypeptide binding]; other site
575540008395	active site
575540008396	product binding site; other site
575540008397	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
575540008398	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
575540008399	putative dimer interface [polypeptide binding]; other site
575540008400	[2Fe-2S] cluster binding site [ion binding]; other site
575540008401	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
575540008402	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
575540008403	SLBB domain; Region: SLBB; pfam10531
575540008404	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
575540008405	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
575540008406	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
575540008407	catalytic loop [active]
575540008408	iron binding site [ion binding]; other site
575540008409	4Fe-4S binding domain; Region: Fer4; cl02805
575540008410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
575540008411	ligand binding site [chemical binding]; other site
575540008412	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
575540008413	ligand binding site [chemical binding]; other site
575540008414	flexible hinge region; other site
575540008415	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
575540008416	4Fe-4S binding domain; Region: Fer4; cl02805
575540008417	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
575540008418	tetramer (dimer of dimers) interface [polypeptide binding]; other site
575540008419	active site
575540008420	dimer interface [polypeptide binding]; other site
575540008421	Dehydratase family; Region: ILVD_EDD; cl00340
575540008422	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
575540008423	23S rRNA interface [nucleotide binding]; other site
575540008424	L3 interface [polypeptide binding]; other site
575540008425	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
575540008426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008427	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
575540008428	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
575540008429	transcription termination factor Rho; Provisional; Region: PRK12678
575540008430	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
575540008431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540008432	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
575540008433	putative catalytic site [active]
575540008434	putative metal binding site [ion binding]; other site
575540008435	putative phosphate binding site [ion binding]; other site
575540008436	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
575540008437	Cytochrome c; Region: Cytochrom_C; cl11414
575540008438	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
575540008439	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
575540008440	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
575540008441	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
575540008442	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
575540008443	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
575540008444	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
575540008445	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
575540008446	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
575540008447	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
575540008448	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
575540008449	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
575540008450	RNA binding site [nucleotide binding]; other site
575540008451	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540008452	FtsX-like permease family; Region: FtsX; cl15850
575540008453	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540008454	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540008455	Walker A/P-loop; other site
575540008456	ATP binding site [chemical binding]; other site
575540008457	Q-loop/lid; other site
575540008458	ABC transporter signature motif; other site
575540008459	Walker B; other site
575540008460	D-loop; other site
575540008461	H-loop/switch region; other site
575540008462	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
575540008463	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540008464	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
575540008465	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
575540008466	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
575540008467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540008468	active site
575540008469	phosphorylation site [posttranslational modification]
575540008470	intermolecular recognition site; other site
575540008471	dimerization interface [polypeptide binding]; other site
575540008472	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
575540008473	DNA binding residues [nucleotide binding]
575540008474	dimerization interface [polypeptide binding]; other site
575540008475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540008476	PAS domain; Region: PAS_9; pfam13426
575540008477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
575540008478	PAS fold; Region: PAS_4; pfam08448
575540008479	PAS fold; Region: PAS_4; pfam08448
575540008480	PAS domain S-box; Region: sensory_box; TIGR00229
575540008481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540008482	PAS domain; Region: PAS_9; pfam13426
575540008483	putative active site [active]
575540008484	heme pocket [chemical binding]; other site
575540008485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540008486	PAS fold; Region: PAS_3; pfam08447
575540008487	putative active site [active]
575540008488	heme pocket [chemical binding]; other site
575540008489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
575540008490	dimer interface [polypeptide binding]; other site
575540008491	phosphorylation site [posttranslational modification]
575540008492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540008493	ATP binding site [chemical binding]; other site
575540008494	Mg2+ binding site [ion binding]; other site
575540008495	G-X-G motif; other site
575540008496	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
575540008497	active site
575540008498	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
575540008499	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
575540008500	RIP metalloprotease RseP; Region: TIGR00054
575540008501	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
575540008502	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
575540008503	putative substrate binding region [chemical binding]; other site
575540008504	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
575540008505	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
575540008506	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
575540008507	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
575540008508	Bacterial sugar transferase; Region: Bac_transf; cl00939
575540008509	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
575540008510	DXD motif; other site
575540008511	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
575540008512	active site
575540008513	substrate binding site [chemical binding]; other site
575540008514	trimer interface [polypeptide binding]; other site
575540008515	CoA binding site [chemical binding]; other site
575540008516	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
575540008517	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540008518	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540008519	metal ion-dependent adhesion site (MIDAS); other site
575540008520	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540008521	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
575540008522	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
575540008523	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
575540008524	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540008525	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
575540008526	putative catalytic site [active]
575540008527	putative metal binding site [ion binding]; other site
575540008528	putative phosphate binding site [ion binding]; other site
575540008529	Sulfatase; Region: Sulfatase; cl10460
575540008530	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
575540008531	Sulfatase; Region: Sulfatase; cl10460
575540008532	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
575540008533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008534	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
575540008535	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
575540008536	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
575540008537	active site
575540008538	ADP/pyrophosphate binding site [chemical binding]; other site
575540008539	dimerization interface [polypeptide binding]; other site
575540008540	allosteric effector site; other site
575540008541	fructose-1,6-bisphosphate binding site; other site
575540008542	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
575540008543	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540008544	motif II; other site
575540008545	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
575540008546	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540008547	PhoD-like phosphatase; Region: PhoD; pfam09423
575540008548	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
575540008549	putative active site [active]
575540008550	putative metal binding site [ion binding]; other site
575540008551	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
575540008552	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
575540008553	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
575540008554	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
575540008555	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
575540008556	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
575540008557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
575540008558	Predicted transcriptional regulator [Transcription]; Region: COG2345
575540008559	putative DNA binding site [nucleotide binding]; other site
575540008560	putative Zn2+ binding site [ion binding]; other site
575540008561	FeS assembly ATPase SufC; Region: sufC; TIGR01978
575540008562	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
575540008563	Walker A/P-loop; other site
575540008564	ATP binding site [chemical binding]; other site
575540008565	Q-loop/lid; other site
575540008566	ABC transporter signature motif; other site
575540008567	Walker B; other site
575540008568	D-loop; other site
575540008569	H-loop/switch region; other site
575540008570	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
575540008571	FeS assembly protein SufB; Region: sufB; TIGR01980
575540008572	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
575540008573	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
575540008574	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
575540008575	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
575540008576	active site residue [active]
575540008577	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
575540008578	active site residue [active]
575540008579	Fe-S metabolism associated domain; Region: SufE; cl00951
575540008580	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
575540008581	[2Fe-2S] cluster binding site [ion binding]; other site
575540008582	Domain of unknown function DUF59; Region: DUF59; cl00941
575540008583	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
575540008584	active site
575540008585	ADP/pyrophosphate binding site [chemical binding]; other site
575540008586	dimerization interface [polypeptide binding]; other site
575540008587	allosteric effector site; other site
575540008588	fructose-1,6-bisphosphate binding site; other site
575540008589	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008590	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540008591	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
575540008592	DNA interaction; other site
575540008593	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
575540008594	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
575540008595	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008596	Walker A/P-loop; other site
575540008597	ATP binding site [chemical binding]; other site
575540008598	Q-loop/lid; other site
575540008599	ABC transporter signature motif; other site
575540008600	Walker B; other site
575540008601	D-loop; other site
575540008602	H-loop/switch region; other site
575540008603	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008604	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
575540008605	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008606	Totivirus coat protein; Region: Totivirus_coat; pfam05518
575540008607	Outer membrane efflux protein; Region: OEP; pfam02321
575540008608	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
575540008609	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008610	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
575540008611	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
575540008612	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540008613	Walker A/P-loop; other site
575540008614	ATP binding site [chemical binding]; other site
575540008615	Q-loop/lid; other site
575540008616	ABC transporter signature motif; other site
575540008617	Walker B; other site
575540008618	D-loop; other site
575540008619	H-loop/switch region; other site
575540008620	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540008621	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
575540008622	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540008623	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
575540008624	Tetratricopeptide repeat; Region: TPR_15; pfam13429
575540008625	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
575540008626	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008627	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540008628	active site
575540008629	ATP binding site [chemical binding]; other site
575540008630	substrate binding site [chemical binding]; other site
575540008631	activation loop (A-loop); other site
575540008632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540008633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540008634	CHAT domain; Region: CHAT; pfam12770
575540008635	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008636	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008637	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008638	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008639	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008640	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008641	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540008642	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
575540008643	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
575540008644	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
575540008645	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
575540008646	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
575540008647	glycyl-tRNA synthetase; Provisional; Region: PRK04173
575540008648	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
575540008649	motif 1; other site
575540008650	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
575540008651	dimer interface [polypeptide binding]; other site
575540008652	active site
575540008653	motif 2; other site
575540008654	motif 3; other site
575540008655	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
575540008656	anticodon binding site; other site
575540008657	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
575540008658	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008659	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540008660	active site
575540008661	ATP binding site [chemical binding]; other site
575540008662	substrate binding site [chemical binding]; other site
575540008663	activation loop (A-loop); other site
575540008664	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008665	Dynamin family; Region: Dynamin_N; pfam00350
575540008666	G1 box; other site
575540008667	GTP/Mg2+ binding site [chemical binding]; other site
575540008668	G2 box; other site
575540008669	Switch I region; other site
575540008670	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008671	G3 box; other site
575540008672	Switch II region; other site
575540008673	G4 box; other site
575540008674	CrcB-like protein; Region: CRCB; cl09114
575540008675	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
575540008676	Ligand binding site; other site
575540008677	Putative Catalytic site; other site
575540008678	DXD motif; other site
575540008679	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
575540008680	Maf-like protein; Region: Maf; pfam02545
575540008681	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
575540008682	active site
575540008683	dimer interface [polypeptide binding]; other site
575540008684	Sodium:solute symporter family; Region: SSF; cl00456
575540008685	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
575540008686	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
575540008687	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
575540008688	PAS domain S-box; Region: sensory_box; TIGR00229
575540008689	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540008690	putative active site [active]
575540008691	heme pocket [chemical binding]; other site
575540008692	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
575540008693	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
575540008694	putative active site [active]
575540008695	heme pocket [chemical binding]; other site
575540008696	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540008697	dimer interface [polypeptide binding]; other site
575540008698	phosphorylation site [posttranslational modification]
575540008699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540008700	ATP binding site [chemical binding]; other site
575540008701	Mg2+ binding site [ion binding]; other site
575540008702	G-X-G motif; other site
575540008703	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
575540008704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540008705	active site
575540008706	phosphorylation site [posttranslational modification]
575540008707	intermolecular recognition site; other site
575540008708	dimerization interface [polypeptide binding]; other site
575540008709	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
575540008710	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
575540008711	CAP-like domain; other site
575540008712	active site
575540008713	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
575540008714	primary dimer interface [polypeptide binding]; other site
575540008715	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
575540008716	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
575540008717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540008718	ATP binding site [chemical binding]; other site
575540008719	Mg2+ binding site [ion binding]; other site
575540008720	G-X-G motif; other site
575540008721	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
575540008722	anchoring element; other site
575540008723	dimer interface [polypeptide binding]; other site
575540008724	ATP binding site [chemical binding]; other site
575540008725	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
575540008726	active site
575540008727	metal binding site [ion binding]; metal-binding site
575540008728	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
575540008729	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
575540008730	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
575540008731	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
575540008732	Fatty acid desaturase; Region: FA_desaturase; pfam00487
575540008733	Di-iron ligands [ion binding]; other site
575540008734	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008735	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
575540008736	NAD(P) binding site [chemical binding]; other site
575540008737	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540008738	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008739	NIPSNAP; Region: NIPSNAP; pfam07978
575540008740	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
575540008741	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540008742	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
575540008743	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
575540008744	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
575540008745	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
575540008746	protein binding site [polypeptide binding]; other site
575540008747	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
575540008748	Domain interface; other site
575540008749	Peptide binding site; other site
575540008750	Active site tetrad [active]
575540008751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540008752	dimer interface [polypeptide binding]; other site
575540008753	phosphorylation site [posttranslational modification]
575540008754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540008755	ATP binding site [chemical binding]; other site
575540008756	Mg2+ binding site [ion binding]; other site
575540008757	G-X-G motif; other site
575540008758	Response regulator receiver domain; Region: Response_reg; pfam00072
575540008759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540008760	active site
575540008761	phosphorylation site [posttranslational modification]
575540008762	intermolecular recognition site; other site
575540008763	dimerization interface [polypeptide binding]; other site
575540008764	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
575540008765	Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446
575540008766	EamA-like transporter family; Region: EamA; cl01037
575540008767	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
575540008768	EamA-like transporter family; Region: EamA; cl01037
575540008769	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
575540008770	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540008771	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
575540008772	DEAD-like helicases superfamily; Region: DEXDc; smart00487
575540008773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540008774	ATP binding site [chemical binding]; other site
575540008775	putative Mg++ binding site [ion binding]; other site
575540008776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540008777	nucleotide binding region [chemical binding]; other site
575540008778	ATP-binding site [chemical binding]; other site
575540008779	Helix-turn-helix domains; Region: HTH; cl00088
575540008780	Duffy binding protein N terminal; Region: DuffyBP_N; pfam12377
575540008781	RQC domain; Region: RQC; cl09632
575540008782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008784	DNA photolyase; Region: DNA_photolyase; pfam00875
575540008785	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
575540008786	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
575540008787	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
575540008788	putative active site [active]
575540008789	Zn binding site [ion binding]; other site
575540008790	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
575540008791	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
575540008792	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
575540008793	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
575540008794	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
575540008795	active site
575540008796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
575540008797	active site
575540008798	motif I; other site
575540008799	motif II; other site
575540008800	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
575540008801	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
575540008802	TM-ABC transporter signature motif; other site
575540008803	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
575540008804	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
575540008805	Walker A/P-loop; other site
575540008806	ATP binding site [chemical binding]; other site
575540008807	Q-loop/lid; other site
575540008808	ABC transporter signature motif; other site
575540008809	Walker B; other site
575540008810	D-loop; other site
575540008811	H-loop/switch region; other site
575540008812	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
575540008813	Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314
575540008814	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
575540008815	ligand binding site [chemical binding]; other site
575540008816	dimerization interface [polypeptide binding]; other site
575540008817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540008818	S-adenosylmethionine binding site [chemical binding]; other site
575540008819	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
575540008820	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
575540008821	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
575540008822	active site
575540008823	catalytic nucleophile [active]
575540008824	dimer interface [polypeptide binding]; other site
575540008825	HEAT repeats; Region: HEAT_2; pfam13646
575540008826	HEAT repeat; Region: HEAT; pfam02985
575540008827	HEAT repeats; Region: HEAT_2; pfam13646
575540008828	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
575540008829	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008830	Walker A/P-loop; other site
575540008831	ATP binding site [chemical binding]; other site
575540008832	Q-loop/lid; other site
575540008833	ABC transporter signature motif; other site
575540008834	Walker B; other site
575540008835	D-loop; other site
575540008836	H-loop/switch region; other site
575540008837	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
575540008838	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
575540008839	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
575540008840	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
575540008841	FAD binding site [chemical binding]; other site
575540008842	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
575540008843	Helix-turn-helix domains; Region: HTH; cl00088
575540008844	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008845	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540008846	active site
575540008847	ATP binding site [chemical binding]; other site
575540008848	substrate binding site [chemical binding]; other site
575540008849	activation loop (A-loop); other site
575540008850	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540008851	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
575540008852	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540008853	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540008854	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
575540008855	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
575540008856	dimerization interface [polypeptide binding]; other site
575540008857	putative ATP binding site [chemical binding]; other site
575540008858	Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137
575540008859	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
575540008860	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
575540008861	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
575540008862	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
575540008863	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540008864	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540008865	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
575540008866	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
575540008867	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540008868	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
575540008869	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
575540008870	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540008871	metal ion-dependent adhesion site (MIDAS); other site
575540008872	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540008873	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
575540008874	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
575540008875	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540008876	FtsX-like permease family; Region: FtsX; cl15850
575540008877	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
575540008878	FtsX-like permease family; Region: FtsX; cl15850
575540008879	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
575540008880	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
575540008881	Walker A/P-loop; other site
575540008882	ATP binding site [chemical binding]; other site
575540008883	Q-loop/lid; other site
575540008884	ABC transporter signature motif; other site
575540008885	Walker B; other site
575540008886	D-loop; other site
575540008887	H-loop/switch region; other site
575540008888	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
575540008889	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008890	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008891	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
575540008892	putative active site [active]
575540008893	catalytic triad [active]
575540008894	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540008895	putative dehydratase; Provisional; Region: PRK08211
575540008896	Dehydratase family; Region: ILVD_EDD; cl00340
575540008897	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
575540008898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008899	NAD(P) binding site [chemical binding]; other site
575540008900	active site
575540008901	Peptidase family M48; Region: Peptidase_M48; cl12018
575540008902	LemA family; Region: LemA; cl00742
575540008903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
575540008904	ABC-ATPase subunit interface; other site
575540008905	NMT1-like family; Region: NMT1_2; cl15260
575540008906	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
575540008907	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
575540008908	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540008909	Walker A/P-loop; other site
575540008910	ATP binding site [chemical binding]; other site
575540008911	Q-loop/lid; other site
575540008912	ABC transporter signature motif; other site
575540008913	Walker B; other site
575540008914	D-loop; other site
575540008915	H-loop/switch region; other site
575540008916	HEAT repeats; Region: HEAT_2; pfam13646
575540008917	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
575540008918	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
575540008919	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008920	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540008921	Right handed beta helix region; Region: Beta_helix; pfam13229
575540008922	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
575540008923	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
575540008924	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540008925	conserved cys residue [active]
575540008926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540008928	active site
575540008929	ATP binding site [chemical binding]; other site
575540008930	substrate binding site [chemical binding]; other site
575540008931	activation loop (A-loop); other site
575540008932	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
575540008933	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
575540008934	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
575540008935	catalytic site [active]
575540008936	subunit interface [polypeptide binding]; other site
575540008937	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540008938	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008939	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540008940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540008941	TPR motif; other site
575540008942	binding surface
575540008943	Family description; Region: VCBS; pfam13517
575540008944	Family description; Region: VCBS; pfam13517
575540008945	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
575540008946	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
575540008947	active site
575540008948	catalytic triad [active]
575540008949	dimer interface [polypeptide binding]; other site
575540008950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540008951	TPR motif; other site
575540008952	binding surface
575540008953	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540008954	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540008955	active site
575540008956	ATP binding site [chemical binding]; other site
575540008957	substrate binding site [chemical binding]; other site
575540008958	activation loop (A-loop); other site
575540008959	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
575540008960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008961	NAD(P) binding site [chemical binding]; other site
575540008962	active site
575540008963	AAA-like domain; Region: AAA_10; pfam12846
575540008964	Domain of unknown function DUF87; Region: DUF87; pfam01935
575540008965	NurA domain; Region: NurA; cl09134
575540008966	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
575540008967	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
575540008968	Mrr N-terminal domain; Region: Mrr_N; pfam14338
575540008969	Restriction endonuclease; Region: Mrr_cat; cl00516
575540008970	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
575540008971	Protein of unknown function (DUF499); Region: DUF499; pfam04465
575540008972	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
575540008973	Protein of unknown function (DUF433); Region: DUF433; cl01030
575540008974	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
575540008975	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
575540008976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008977	Transposase IS200 like; Region: Y1_Tnp; cl00848
575540008978	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
575540008979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540008980	ATP binding site [chemical binding]; other site
575540008981	putative Mg++ binding site [ion binding]; other site
575540008982	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
575540008983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540008984	nucleotide binding region [chemical binding]; other site
575540008985	ATP-binding site [chemical binding]; other site
575540008986	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
575540008987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540008988	ATP binding site [chemical binding]; other site
575540008989	putative Mg++ binding site [ion binding]; other site
575540008990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540008992	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
575540008993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
575540008994	ATP binding site [chemical binding]; other site
575540008995	putative Mg++ binding site [ion binding]; other site
575540008996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
575540008997	nucleotide binding region [chemical binding]; other site
575540008998	ATP-binding site [chemical binding]; other site
575540008999	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
575540009000	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
575540009001	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540009002	Global regulator protein family; Region: CsrA; cl00670
575540009003	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
575540009004	intracellular protease, PfpI family; Region: PfpI; TIGR01382
575540009005	conserved cys residue [active]
575540009006	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
575540009007	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
575540009008	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009009	Walker A/P-loop; other site
575540009010	ATP binding site [chemical binding]; other site
575540009011	Q-loop/lid; other site
575540009012	ABC transporter signature motif; other site
575540009013	Walker B; other site
575540009014	D-loop; other site
575540009015	H-loop/switch region; other site
575540009016	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
575540009017	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540009018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540009019	active site
575540009020	ATP binding site [chemical binding]; other site
575540009021	substrate binding site [chemical binding]; other site
575540009022	activation loop (A-loop); other site
575540009023	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
575540009024	active site
575540009025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
575540009026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
575540009027	Coenzyme A binding pocket [chemical binding]; other site
575540009028	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540009029	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
575540009030	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540009031	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
575540009032	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
575540009033	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
575540009034	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540009035	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
575540009036	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009037	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009038	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
575540009039	FAD binding domain; Region: FAD_binding_4; pfam01565
575540009040	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
575540009041	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
575540009042	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
575540009043	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
575540009044	active site
575540009045	intersubunit interface [polypeptide binding]; other site
575540009046	catalytic residue [active]
575540009047	Uncharacterized conserved protein [Function unknown]; Region: COG2006
575540009048	Domain of unknown function (DUF362); Region: DUF362; pfam04015
575540009049	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540009050	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540009051	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
575540009052	active site
575540009053	catalytic residues [active]
575540009054	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
575540009055	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
575540009056	Cytochrome c; Region: Cytochrom_C; cl11414
575540009057	PA14 domain; Region: PA14; cl08459
575540009058	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
575540009059	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
575540009060	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
575540009061	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
575540009062	benzoate transport; Region: 2A0115; TIGR00895
575540009063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540009064	putative substrate translocation pore; other site
575540009065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
575540009066	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
575540009067	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
575540009068	active site
575540009069	catalytic tetrad [active]
575540009070	Global regulator protein family; Region: CsrA; cl00670
575540009071	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009073	active site
575540009074	phosphorylation site [posttranslational modification]
575540009075	intermolecular recognition site; other site
575540009076	dimerization interface [polypeptide binding]; other site
575540009077	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
575540009078	Low molecular weight phosphatase family; Region: LMWPc; cd00115
575540009079	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
575540009080	active site
575540009081	Protein of unknown function (DUF493); Region: DUF493; cl01102
575540009082	ribonuclease PH; Reviewed; Region: rph; PRK00173
575540009083	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
575540009084	oligomer interface [polypeptide binding]; other site
575540009085	RNA binding site [nucleotide binding]; other site
575540009086	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
575540009087	active site
575540009088	dimerization interface [polypeptide binding]; other site
575540009089	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540009090	active site
575540009091	catalytic residues [active]
575540009092	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
575540009093	NMT1-like family; Region: NMT1_2; cl15260
575540009094	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
575540009095	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009096	Walker A/P-loop; other site
575540009097	ATP binding site [chemical binding]; other site
575540009098	Q-loop/lid; other site
575540009099	ABC transporter signature motif; other site
575540009100	Walker B; other site
575540009101	D-loop; other site
575540009102	H-loop/switch region; other site
575540009103	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
575540009104	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
575540009105	glutamine binding [chemical binding]; other site
575540009106	catalytic triad [active]
575540009107	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
575540009108	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
575540009109	dimer interface [polypeptide binding]; other site
575540009110	putative functional site; other site
575540009111	putative MPT binding site; other site
575540009112	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
575540009113	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
575540009114	putative active site [active]
575540009115	catalytic triad [active]
575540009116	putative dimer interface [polypeptide binding]; other site
575540009117	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009118	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
575540009119	DnaA box-binding interface [nucleotide binding]; other site
575540009120	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
575540009121	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540009122	active site
575540009123	metal binding site [ion binding]; metal-binding site
575540009124	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
575540009125	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540009126	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540009127	ABC transporter; Region: ABC_tran_2; pfam12848
575540009128	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
575540009129	Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191
575540009130	L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
575540009131	N- and C-terminal domain interface [polypeptide binding]; other site
575540009132	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
575540009133	active site
575540009134	catalytic site [active]
575540009135	metal binding site [ion binding]; metal-binding site
575540009136	ATP binding site [chemical binding]; other site
575540009137	carbohydrate binding site [chemical binding]; other site
575540009138	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
575540009139	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540009140	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540009141	active site
575540009142	ATP binding site [chemical binding]; other site
575540009143	substrate binding site [chemical binding]; other site
575540009144	activation loop (A-loop); other site
575540009145	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540009146	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
575540009147	active site
575540009148	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540009149	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
575540009150	Ligand binding site; other site
575540009151	Putative Catalytic site; other site
575540009152	DXD motif; other site
575540009153	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
575540009154	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
575540009155	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540009156	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
575540009157	NeuB family; Region: NeuB; cl00496
575540009158	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009159	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
575540009160	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
575540009161	active site
575540009162	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
575540009163	Protein of unknown function, DUF393; Region: DUF393; cl01136
575540009164	serine racemase; Region: PLN02970
575540009165	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
575540009166	tetramer interface [polypeptide binding]; other site
575540009167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540009168	catalytic residue [active]
575540009169	TPR repeat; Region: TPR_11; pfam13414
575540009170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009171	binding surface
575540009172	TPR motif; other site
575540009173	Protein kinase domain; Region: Pkinase; pfam00069
575540009174	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540009175	active site
575540009176	ATP binding site [chemical binding]; other site
575540009177	substrate binding site [chemical binding]; other site
575540009178	activation loop (A-loop); other site
575540009179	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540009180	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
575540009181	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
575540009182	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
575540009183	active site
575540009184	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
575540009185	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
575540009186	ADP binding site [chemical binding]; other site
575540009187	phosphagen binding site; other site
575540009188	substrate specificity loop; other site
575540009189	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
575540009190	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
575540009191	UvrB/uvrC motif; Region: UVR; pfam02151
575540009192	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
575540009193	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
575540009194	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
575540009195	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
575540009196	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
575540009197	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
575540009198	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
575540009199	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
575540009200	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
575540009201	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
575540009202	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
575540009203	DNA binding site [nucleotide binding]
575540009204	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
575540009205	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
575540009206	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
575540009207	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
575540009208	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
575540009209	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
575540009210	G1 box; other site
575540009211	putative GEF interaction site [polypeptide binding]; other site
575540009212	GTP/Mg2+ binding site [chemical binding]; other site
575540009213	Switch I region; other site
575540009214	G2 box; other site
575540009215	G3 box; other site
575540009216	Switch II region; other site
575540009217	G4 box; other site
575540009218	G5 box; other site
575540009219	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
575540009220	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
575540009221	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
575540009222	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
575540009223	Protein of unknown function (DUF520); Region: DUF520; cl00723
575540009224	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
575540009225	16S/18S rRNA binding site [nucleotide binding]; other site
575540009226	S13e-L30e interaction site [polypeptide binding]; other site
575540009227	25S rRNA binding site [nucleotide binding]; other site
575540009228	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
575540009229	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
575540009230	RNase E interface [polypeptide binding]; other site
575540009231	trimer interface [polypeptide binding]; other site
575540009232	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
575540009233	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
575540009234	RNase E interface [polypeptide binding]; other site
575540009235	trimer interface [polypeptide binding]; other site
575540009236	active site
575540009237	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
575540009238	putative nucleic acid binding region [nucleotide binding]; other site
575540009239	G-X-X-G motif; other site
575540009240	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
575540009241	RNA binding site [nucleotide binding]; other site
575540009242	domain interface; other site
575540009243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
575540009244	dimer interface [polypeptide binding]; other site
575540009245	phosphorylation site [posttranslational modification]
575540009246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540009247	ATP binding site [chemical binding]; other site
575540009248	G-X-G motif; other site
575540009249	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
575540009250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009251	active site
575540009252	phosphorylation site [posttranslational modification]
575540009253	intermolecular recognition site; other site
575540009254	dimerization interface [polypeptide binding]; other site
575540009255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540009256	Walker A motif; other site
575540009257	ATP binding site [chemical binding]; other site
575540009258	Walker B motif; other site
575540009259	arginine finger; other site
575540009260	Helix-turn-helix domains; Region: HTH; cl00088
575540009261	DoxX; Region: DoxX; cl00976
575540009262	polyphosphate kinase; Provisional; Region: PRK05443
575540009263	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
575540009264	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
575540009265	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
575540009266	putative domain interface [polypeptide binding]; other site
575540009267	putative active site [active]
575540009268	catalytic site [active]
575540009269	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
575540009270	putative domain interface [polypeptide binding]; other site
575540009271	putative active site [active]
575540009272	catalytic site [active]
575540009273	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
575540009274	endonuclease IV; Provisional; Region: PRK01060
575540009275	AP (apurinic/apyrimidinic) site pocket; other site
575540009276	DNA interaction; other site
575540009277	Metal-binding active site; metal-binding site
575540009278	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
575540009279	heterotetramer interface [polypeptide binding]; other site
575540009280	active site pocket [active]
575540009281	cleavage site
575540009282	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
575540009283	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
575540009284	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
575540009285	putative substrate binding site [chemical binding]; other site
575540009286	putative ATP binding site [chemical binding]; other site
575540009287	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
575540009288	AIR carboxylase; Region: AIRC; cl00310
575540009289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
575540009290	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
575540009291	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
575540009292	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
575540009293	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
575540009294	active site lid residues [active]
575540009295	substrate binding pocket [chemical binding]; other site
575540009296	catalytic residues [active]
575540009297	substrate-Mg2+ binding site; other site
575540009298	aspartate-rich region 1; other site
575540009299	aspartate-rich region 2; other site
575540009300	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
575540009301	active site lid residues [active]
575540009302	substrate binding pocket [chemical binding]; other site
575540009303	catalytic residues [active]
575540009304	substrate-Mg2+ binding site; other site
575540009305	aspartate-rich region 1; other site
575540009306	aspartate-rich region 2; other site
575540009307	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
575540009308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009309	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
575540009310	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
575540009311	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
575540009312	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
575540009313	putative active site [active]
575540009314	catalytic site [active]
575540009315	putative metal binding site [ion binding]; other site
575540009316	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
575540009317	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540009318	FeS/SAM binding site; other site
575540009319	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
575540009320	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
575540009321	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
575540009322	Probable Catalytic site; other site
575540009323	mercuric reductase; Validated; Region: PRK06370
575540009324	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
575540009325	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
575540009326	Protein of unknown function DUF72; Region: DUF72; cl00777
575540009327	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009329	active site
575540009330	phosphorylation site [posttranslational modification]
575540009331	intermolecular recognition site; other site
575540009332	dimerization interface [polypeptide binding]; other site
575540009333	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
575540009334	HEAT repeats; Region: HEAT_2; pfam13646
575540009335	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
575540009336	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
575540009337	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
575540009338	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
575540009339	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
575540009340	substrate binding site [chemical binding]; other site
575540009341	hexamer interface [polypeptide binding]; other site
575540009342	metal binding site [ion binding]; metal-binding site
575540009343	Phosphoglycerate kinase; Region: PGK; pfam00162
575540009344	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
575540009345	substrate binding site [chemical binding]; other site
575540009346	hinge regions; other site
575540009347	ADP binding site [chemical binding]; other site
575540009348	catalytic site [active]
575540009349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009350	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
575540009351	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
575540009352	hypothetical protein; Provisional; Region: PRK07877
575540009353	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
575540009354	FMN binding site [chemical binding]; other site
575540009355	dimer interface [polypeptide binding]; other site
575540009356	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540009357	OsmC-like protein; Region: OsmC; cl00767
575540009358	Cytochrome c; Region: Cytochrom_C; cl11414
575540009359	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
575540009360	structural tetrad; other site
575540009361	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540009362	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540009363	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
575540009364	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
575540009365	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540009366	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
575540009367	RNA/DNA hybrid binding site [nucleotide binding]; other site
575540009368	active site
575540009369	flavoprotein, HI0933 family; Region: TIGR00275
575540009370	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009371	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
575540009372	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
575540009373	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
575540009374	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
575540009375	phosphate binding site [ion binding]; other site
575540009376	ATP-grasp domain; Region: ATP-grasp_4; cl03087
575540009377	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
575540009378	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
575540009379	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540009380	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540009381	metal ion-dependent adhesion site (MIDAS); other site
575540009382	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
575540009383	NPCBM/NEW2 domain; Region: NPCBM; cl07060
575540009384	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
575540009385	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
575540009386	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
575540009387	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
575540009388	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540009389	metal ion-dependent adhesion site (MIDAS); other site
575540009390	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
575540009391	Aerotolerance regulator N-terminal; Region: BatA; cl06567
575540009392	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540009393	metal ion-dependent adhesion site (MIDAS); other site
575540009394	Fibronectin type III-like domain; Region: Fn3-like; cl15273
575540009395	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540009396	metal ion-dependent adhesion site (MIDAS); other site
575540009397	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540009398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
575540009399	Walker A motif; other site
575540009400	ATP binding site [chemical binding]; other site
575540009401	Walker B motif; other site
575540009402	arginine finger; other site
575540009403	PQQ-like domain; Region: PQQ_2; pfam13360
575540009404	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
575540009405	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
575540009406	Tetratricopeptide repeat; Region: TPR_16; pfam13432
575540009407	PQQ-like domain; Region: PQQ_2; pfam13360
575540009408	PQQ-like domain; Region: PQQ_2; pfam13360
575540009409	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
575540009410	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
575540009411	tRNA; other site
575540009412	putative tRNA binding site [nucleotide binding]; other site
575540009413	putative NADP binding site [chemical binding]; other site
575540009414	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
575540009415	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
575540009416	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
575540009417	phosphopeptide binding site; other site
575540009418	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
575540009419	metal binding site [ion binding]; metal-binding site
575540009420	active site
575540009421	I-site; other site
575540009422	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540009423	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540009424	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
575540009425	catalytic triad [active]
575540009426	LexA repressor; Validated; Region: PRK00215
575540009427	Helix-turn-helix domains; Region: HTH; cl00088
575540009428	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
575540009429	Catalytic site [active]
575540009430	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
575540009431	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
575540009432	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
575540009433	tetrameric interface [polypeptide binding]; other site
575540009434	NAD binding site [chemical binding]; other site
575540009435	catalytic residues [active]
575540009436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009437	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
575540009438	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009439	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
575540009440	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
575540009441	putative catalytic cysteine [active]
575540009442	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
575540009443	dihydropteroate synthase; Region: DHPS; TIGR01496
575540009444	substrate binding pocket [chemical binding]; other site
575540009445	dimer interface [polypeptide binding]; other site
575540009446	inhibitor binding site; inhibition site
575540009447	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
575540009448	Tetratricopeptide repeat; Region: TPR_6; pfam13174
575540009449	Tetratricopeptide repeat; Region: TPR_6; pfam13174
575540009450	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
575540009451	Recombination protein O N terminal; Region: RecO_N; cl15812
575540009452	Recombination protein O C terminal; Region: RecO_C; pfam02565
575540009453	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
575540009454	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
575540009455	DNA binding residues [nucleotide binding]
575540009456	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
575540009457	B12 binding site [chemical binding]; other site
575540009458	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
575540009459	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
575540009460	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
575540009461	DNA binding residues [nucleotide binding]
575540009462	MoxR-like ATPases [General function prediction only]; Region: COG0714
575540009463	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009464	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540009465	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540009466	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
575540009467	metal ion-dependent adhesion site (MIDAS); other site
575540009468	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
575540009469	EamA-like transporter family; Region: EamA; cl01037
575540009470	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
575540009471	EamA-like transporter family; Region: EamA; cl01037
575540009472	amino acid transporter; Region: 2A0306; TIGR00909
575540009473	Spore germination protein; Region: Spore_permease; cl15802
575540009474	Spore germination protein; Region: Spore_permease; cl15802
575540009475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009476	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
575540009477	active site
575540009478	metal binding site [ion binding]; metal-binding site
575540009479	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
575540009480	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540009481	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
575540009482	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
575540009483	active site
575540009484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
575540009485	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
575540009486	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
575540009487	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
575540009488	Coenzyme A binding pocket [chemical binding]; other site
575540009489	Phosphotransferase enzyme family; Region: APH; pfam01636
575540009490	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540009491	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
575540009492	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
575540009493	ResB-like family; Region: ResB; pfam05140
575540009494	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
575540009495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009496	binding surface
575540009497	TPR motif; other site
575540009498	TPR repeat; Region: TPR_11; pfam13414
575540009499	Peptidase C26; Region: Peptidase_C26; pfam07722
575540009500	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
575540009501	catalytic triad [active]
575540009502	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
575540009503	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
575540009504	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
575540009505	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009506	Walker A/P-loop; other site
575540009507	ATP binding site [chemical binding]; other site
575540009508	Q-loop/lid; other site
575540009509	ABC transporter signature motif; other site
575540009510	Walker B; other site
575540009511	D-loop; other site
575540009512	H-loop/switch region; other site
575540009513	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
575540009514	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
575540009515	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
575540009516	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
575540009517	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
575540009518	active site
575540009519	catalytic triad [active]
575540009520	oxyanion hole [active]
575540009521	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540009523	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540009524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
575540009525	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540009526	binding surface
575540009527	TPR motif; other site
575540009528	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540009529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009530	binding surface
575540009531	TPR motif; other site
575540009532	TPR repeat; Region: TPR_11; pfam13414
575540009533	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540009534	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
575540009535	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
575540009536	tetramer interface [polypeptide binding]; other site
575540009537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540009538	catalytic residue [active]
575540009539	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
575540009540	histidinol dehydrogenase; Region: hisD; TIGR00069
575540009541	NAD binding site [chemical binding]; other site
575540009542	dimerization interface [polypeptide binding]; other site
575540009543	product binding site; other site
575540009544	substrate binding site [chemical binding]; other site
575540009545	zinc binding site [ion binding]; other site
575540009546	catalytic residues [active]
575540009547	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
575540009548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
575540009549	Coenzyme A binding pocket [chemical binding]; other site
575540009550	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
575540009551	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
575540009552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540009553	homodimer interface [polypeptide binding]; other site
575540009554	catalytic residue [active]
575540009555	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
575540009556	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
575540009557	putative active site pocket [active]
575540009558	4-fold oligomerization interface [polypeptide binding]; other site
575540009559	metal binding residues [ion binding]; metal-binding site
575540009560	3-fold/trimer interface [polypeptide binding]; other site
575540009561	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
575540009562	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
575540009563	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540009564	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
575540009565	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
575540009566	NAD binding site [chemical binding]; other site
575540009567	homodimer interface [polypeptide binding]; other site
575540009568	active site
575540009569	substrate binding site [chemical binding]; other site
575540009570	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
575540009571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009572	NAD(P) binding site [chemical binding]; other site
575540009573	active site
575540009574	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540009575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009576	GAF domain; Region: GAF; cl15785
575540009577	GAF domain; Region: GAF_2; pfam13185
575540009578	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009580	active site
575540009581	phosphorylation site [posttranslational modification]
575540009582	intermolecular recognition site; other site
575540009583	dimerization interface [polypeptide binding]; other site
575540009584	BNR repeat-like domain; Region: BNR_2; pfam13088
575540009585	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
575540009586	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
575540009587	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
575540009588	Cytochrome c; Region: Cytochrom_C; cl11414
575540009589	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
575540009590	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
575540009591	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
575540009592	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
575540009593	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
575540009594	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
575540009595	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
575540009596	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
575540009597	active site
575540009598	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
575540009599	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
575540009600	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
575540009601	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540009602	active site
575540009603	ATP binding site [chemical binding]; other site
575540009604	substrate binding site [chemical binding]; other site
575540009605	activation loop (A-loop); other site
575540009606	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
575540009607	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
575540009608	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
575540009609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540009611	S-adenosylmethionine binding site [chemical binding]; other site
575540009612	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
575540009613	guanine deaminase; Provisional; Region: PRK09228
575540009614	active site
575540009615	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
575540009616	active site
575540009617	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540009618	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540009619	active site
575540009620	ATP binding site [chemical binding]; other site
575540009621	substrate binding site [chemical binding]; other site
575540009622	activation loop (A-loop); other site
575540009623	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
575540009624	Catalytic domain of Protein Kinases; Region: PKc; cd00180
575540009625	active site
575540009626	ATP binding site [chemical binding]; other site
575540009627	substrate binding site [chemical binding]; other site
575540009628	activation loop (A-loop); other site
575540009629	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
575540009630	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
575540009631	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540009632	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
575540009633	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540009634	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
575540009635	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
575540009636	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
575540009637	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
575540009638	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
575540009639	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
575540009640	4Fe-4S binding domain; Region: Fer4; cl02805
575540009641	4Fe-4S binding domain; Region: Fer4; cl02805
575540009642	NADH dehydrogenase; Region: NADHdh; cl00469
575540009643	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
575540009644	catalytic loop [active]
575540009645	iron binding site [ion binding]; other site
575540009646	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
575540009647	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
575540009648	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
575540009649	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
575540009650	molybdopterin cofactor binding site; other site
575540009651	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
575540009652	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
575540009653	SLBB domain; Region: SLBB; pfam10531
575540009654	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
575540009655	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
575540009656	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
575540009657	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540009658	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
575540009659	catalytic Zn binding site [ion binding]; other site
575540009660	putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
575540009661	structural Zn binding site [ion binding]; other site
575540009662	tetramer interface [polypeptide binding]; other site
575540009663	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540009664	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
575540009665	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540009666	Fibronectin type III-like domain; Region: Fn3-like; cl15273
575540009667	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
575540009668	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
575540009669	active site
575540009670	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
575540009671	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
575540009672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009673	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540009674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009675	Helix-turn-helix domains; Region: HTH; cl00088
575540009676	ParB-like nuclease domain; Region: ParBc; cl02129
575540009677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009679	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
575540009680	active site
575540009681	ribulose/triose binding site [chemical binding]; other site
575540009682	phosphate binding site [ion binding]; other site
575540009683	substrate (anthranilate) binding pocket [chemical binding]; other site
575540009684	product (indole) binding pocket [chemical binding]; other site
575540009685	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
575540009686	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
575540009687	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
575540009688	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
575540009689	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
575540009690	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
575540009691	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
575540009692	protein binding site [polypeptide binding]; other site
575540009693	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
575540009694	TPR repeat; Region: TPR_11; pfam13414
575540009695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009696	binding surface
575540009697	TPR motif; other site
575540009698	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540009699	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009700	TPR motif; other site
575540009701	binding surface
575540009702	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009704	active site
575540009705	phosphorylation site [posttranslational modification]
575540009706	intermolecular recognition site; other site
575540009707	dimerization interface [polypeptide binding]; other site
575540009708	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
575540009709	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540009710	Sulfatase; Region: Sulfatase; cl10460
575540009711	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
575540009712	Sulfatase; Region: Sulfatase; cl10460
575540009713	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
575540009714	homotrimer interaction site [polypeptide binding]; other site
575540009715	zinc binding site [ion binding]; other site
575540009716	CDP-binding sites; other site
575540009717	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
575540009718	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
575540009719	active site
575540009720	HIGH motif; other site
575540009721	nucleotide binding site [chemical binding]; other site
575540009722	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
575540009723	KMSKS motif; other site
575540009724	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
575540009725	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
575540009726	active site
575540009727	putative DNA-binding cleft [nucleotide binding]; other site
575540009728	dimer interface [polypeptide binding]; other site
575540009729	bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840
575540009730	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
575540009731	thiS-thiF/thiG interaction site; other site
575540009732	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
575540009733	ThiS interaction site; other site
575540009734	putative active site [active]
575540009735	tetramer interface [polypeptide binding]; other site
575540009736	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009738	active site
575540009739	phosphorylation site [posttranslational modification]
575540009740	intermolecular recognition site; other site
575540009741	dimerization interface [polypeptide binding]; other site
575540009742	Tetratricopeptide repeat; Region: TPR_12; pfam13424
575540009743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
575540009744	binding surface
575540009745	TPR motif; other site
575540009746	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
575540009747	putative CheA interaction surface; other site
575540009748	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
575540009749	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
575540009750	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
575540009751	dimer interface [polypeptide binding]; other site
575540009752	putative CheW interface [polypeptide binding]; other site
575540009753	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
575540009754	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540009755	putative binding surface; other site
575540009756	active site
575540009757	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540009758	putative binding surface; other site
575540009759	active site
575540009760	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540009761	putative binding surface; other site
575540009762	active site
575540009763	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
575540009764	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
575540009765	putative binding surface; other site
575540009766	active site
575540009767	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
575540009768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
575540009769	ATP binding site [chemical binding]; other site
575540009770	Mg2+ binding site [ion binding]; other site
575540009771	G-X-G motif; other site
575540009772	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
575540009773	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009775	active site
575540009776	phosphorylation site [posttranslational modification]
575540009777	intermolecular recognition site; other site
575540009778	dimerization interface [polypeptide binding]; other site
575540009779	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
575540009780	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
575540009781	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
575540009782	putative ADP-binding pocket [chemical binding]; other site
575540009783	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
575540009784	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
575540009785	ABC-2 type transporter; Region: ABC2_membrane; cl11417
575540009786	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
575540009787	MAEBL; Provisional; Region: PTZ00121
575540009788	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
575540009789	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
575540009790	Walker A/P-loop; other site
575540009791	ATP binding site [chemical binding]; other site
575540009792	Q-loop/lid; other site
575540009793	ABC transporter signature motif; other site
575540009794	Walker B; other site
575540009795	D-loop; other site
575540009796	H-loop/switch region; other site
575540009797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009798	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
575540009799	Sulfate transporter family; Region: Sulfate_transp; cl15842
575540009800	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
575540009801	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
575540009802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
575540009803	Predicted esterase [General function prediction only]; Region: COG0400
575540009804	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
575540009805	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
575540009806	Ligand binding site; other site
575540009807	Putative Catalytic site; other site
575540009808	DXD motif; other site
575540009809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
575540009810	S-adenosylmethionine binding site [chemical binding]; other site
575540009811	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
575540009812	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
575540009813	DNA-binding site [nucleotide binding]; DNA binding site
575540009814	RNA-binding motif; other site
575540009815	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
575540009816	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
575540009817	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
575540009818	active site
575540009819	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
575540009820	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
575540009821	Kelch motif; Region: Kelch_1; cl02701
575540009822	Kelch motif; Region: Kelch_1; cl02701
575540009823	kelch-like protein; Provisional; Region: PHA03098
575540009824	Kelch motif; Region: Kelch_1; cl02701
575540009825	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
575540009826	active site
575540009827	putative substrate binding region [chemical binding]; other site
575540009828	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
575540009829	Response regulator receiver domain; Region: Response_reg; pfam00072
575540009830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
575540009831	active site
575540009832	phosphorylation site [posttranslational modification]
575540009833	intermolecular recognition site; other site
575540009834	dimerization interface [polypeptide binding]; other site
575540009835	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
575540009836	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
575540009837	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
575540009838	active site
575540009839	catalytic tetrad [active]
575540009840	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
575540009841	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
575540009842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
575540009843	FeS/SAM binding site; other site
575540009844	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
575540009845	Helix-turn-helix domains; Region: HTH; cl00088
575540009846	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
575540009847	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540009848	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
575540009849	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
575540009850	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
575540009851	Isochorismatase family; Region: Isochorismatase; pfam00857
575540009852	catalytic triad [active]
575540009853	dimer interface [polypeptide binding]; other site
575540009854	conserved cis-peptide bond; other site
575540009855	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
575540009856	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
575540009857	homodimer interface [polypeptide binding]; other site
575540009858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
575540009859	catalytic residue [active]
575540009860	TPR repeat; Region: TPR_11; pfam13414
575540009861	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
575540009862	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
575540009863	SpoVG; Region: SpoVG; cl00915
575540009864	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
575540009865	pyruvate kinase; Provisional; Region: PRK05826
575540009866	domain interfaces; other site
575540009867	active site