-- dump date 20140619_121056 -- class Genbank::misc_feature -- table misc_feature_note -- id note 507522000001 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 507522000002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522000004 short chain dehydrogenase; Provisional; Region: PRK06180 507522000005 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 507522000006 NADP binding site [chemical binding]; other site 507522000007 active site 507522000008 steroid binding site; other site 507522000009 Transposase; Region: DEDD_Tnp_IS110; pfam01548 507522000010 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 507522000011 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 507522000012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522000013 NAD(P) binding site [chemical binding]; other site 507522000014 active site 507522000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522000016 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 507522000017 NAD(P) binding site [chemical binding]; other site 507522000018 active site 507522000019 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522000020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000021 putative substrate translocation pore; other site 507522000022 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 507522000023 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 507522000024 conserved cys residue [active] 507522000025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522000027 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 507522000028 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 507522000029 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 507522000030 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 507522000031 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522000032 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522000033 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522000034 putative active site [active] 507522000035 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 507522000036 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 507522000037 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522000038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522000039 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 507522000040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522000041 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522000042 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 507522000043 Fusaric acid resistance protein family; Region: FUSC; pfam04632 507522000044 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522000045 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522000046 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522000047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000048 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 507522000049 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 507522000050 conserved cys residue [active] 507522000051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000052 DJ-1 family protein; Region: not_thiJ; TIGR01383 507522000053 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 507522000054 conserved cys residue [active] 507522000055 short chain dehydrogenase; Provisional; Region: PRK06500 507522000056 classical (c) SDRs; Region: SDR_c; cd05233 507522000057 NAD(P) binding site [chemical binding]; other site 507522000058 active site 507522000059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522000060 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522000061 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 507522000062 catalytic residues [active] 507522000063 catalytic nucleophile [active] 507522000064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522000065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522000066 Coenzyme A binding pocket [chemical binding]; other site 507522000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 507522000068 Integrase core domain; Region: rve; pfam00665 507522000069 transketolase; Reviewed; Region: PRK12753 507522000070 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522000071 TPP-binding site [chemical binding]; other site 507522000072 dimer interface [polypeptide binding]; other site 507522000073 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522000074 PYR/PP interface [polypeptide binding]; other site 507522000075 dimer interface [polypeptide binding]; other site 507522000076 TPP binding site [chemical binding]; other site 507522000077 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522000078 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522000079 active site 507522000080 phosphorylation site [posttranslational modification] 507522000081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522000082 DNA-binding site [nucleotide binding]; DNA binding site 507522000083 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522000084 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 507522000085 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 507522000086 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 507522000087 NAD(P) binding site [chemical binding]; other site 507522000088 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 507522000089 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 507522000090 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 507522000091 active site 507522000092 P-loop; other site 507522000093 phosphorylation site [posttranslational modification] 507522000094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 507522000095 HTH-like domain; Region: HTH_21; pfam13276 507522000096 Integrase core domain; Region: rve; pfam00665 507522000097 Integrase core domain; Region: rve_3; pfam13683 507522000098 Transposase; Region: HTH_Tnp_1; pfam01527 507522000099 Winged helix-turn helix; Region: HTH_29; pfam13551 507522000100 Helix-turn-helix domain; Region: HTH_28; pfam13518 507522000101 Homeodomain-like domain; Region: HTH_32; pfam13565 507522000102 Integrase core domain; Region: rve; pfam00665 507522000103 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 507522000104 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 507522000105 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 507522000106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522000107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522000108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522000109 non-specific DNA binding site [nucleotide binding]; other site 507522000110 salt bridge; other site 507522000111 sequence-specific DNA binding site [nucleotide binding]; other site 507522000112 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 507522000113 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 507522000114 Transposase; Region: DEDD_Tnp_IS110; pfam01548 507522000115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 507522000116 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 507522000117 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522000118 Helix-turn-helix domain; Region: HTH_18; pfam12833 507522000119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000120 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 507522000121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000122 putative substrate translocation pore; other site 507522000123 Flavin Reductases; Region: FlaRed; cl00801 507522000124 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 507522000125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522000126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522000127 active site 507522000128 catalytic tetrad [active] 507522000129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522000130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522000132 dimerization interface [polypeptide binding]; other site 507522000133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522000134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522000136 putative effector binding pocket; other site 507522000137 putative dimerization interface [polypeptide binding]; other site 507522000138 hypothetical protein; Provisional; Region: PRK08204 507522000139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522000140 active site 507522000141 Protein of unknown function, DUF606; Region: DUF606; pfam04657 507522000142 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 507522000143 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 507522000144 NmrA-like family; Region: NmrA; pfam05368 507522000145 NAD(P) binding site [chemical binding]; other site 507522000146 active site lysine 507522000147 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522000148 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522000149 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 507522000150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522000151 Transposase; Region: DEDD_Tnp_IS110; pfam01548 507522000152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 507522000153 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 507522000154 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 507522000155 active site 507522000156 AAA domain; Region: AAA_23; pfam13476 507522000157 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 507522000158 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 507522000159 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 507522000160 activation loop (A-loop); other site 507522000161 replication protein; Provisional; Region: PRK13742 507522000162 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 507522000163 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 507522000164 P-loop; other site 507522000165 Magnesium ion binding site [ion binding]; other site 507522000166 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 507522000167 Magnesium ion binding site [ion binding]; other site 507522000168 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 507522000169 ParB-like nuclease domain; Region: ParBc; pfam02195 507522000170 ParB family; Region: ParB; pfam08775 507522000171 TraU protein; Region: TraU; cl06067 507522000172 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 507522000173 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 507522000174 conjugal transfer protein TrbE; Provisional; Region: PRK13718 507522000175 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 507522000176 F plasmid transfer operon protein; Region: TraF; pfam13728 507522000177 TraX protein; Region: TraX; cl05434 507522000178 conjugal transfer protein TrbP; Provisional; Region: PRK13882 507522000179 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 507522000180 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 507522000181 ProQ/FINO family; Region: ProQ; pfam04352 507522000182 putative RNA binding sites [nucleotide binding]; other site 507522000183 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 507522000184 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 507522000185 PLD-like domain; Region: PLDc_2; pfam13091 507522000186 putative active site [active] 507522000187 catalytic site [active] 507522000188 replication protein; Provisional; Region: PRK13702 507522000189 Tap RepA1 leader peptide; Region: RepA1_leader; cl15387 507522000190 replication protein; Provisional; Region: PRK13750 507522000191 Haemolysin expression modulating protein; Region: HHA; cl11501 507522000192 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 507522000193 DNA binding site [nucleotide binding] 507522000194 dimer interface [polypeptide binding]; other site 507522000195 active site 507522000196 Int/Topo IB signature motif; other site 507522000197 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 507522000198 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 507522000199 DNA-binding interface [nucleotide binding]; DNA binding site 507522000200 Winged helix-turn helix; Region: HTH_29; pfam13551 507522000201 putative transposase OrfB; Reviewed; Region: PHA02517 507522000202 HTH-like domain; Region: HTH_21; pfam13276 507522000203 Integrase core domain; Region: rve; pfam00665 507522000204 Integrase core domain; Region: rve_3; pfam13683 507522000205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 507522000206 Transposase; Region: DDE_Tnp_ISL3; pfam01610 507522000207 plasmid-partitioning protein; Provisional; Region: PRK13698 507522000208 ParB-like nuclease domain; Region: ParB; smart00470 507522000209 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 507522000210 MerR family regulatory protein; Region: MerR; pfam00376 507522000211 DNA binding residues [nucleotide binding] 507522000212 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 507522000213 P-loop; other site 507522000214 Magnesium ion binding site [ion binding]; other site 507522000215 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 507522000216 Magnesium ion binding site [ion binding]; other site 507522000217 Initiator Replication protein; Region: Rep_3; pfam01051 507522000218 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 507522000219 active site 507522000220 catalytic residues [active] 507522000221 DNA binding site [nucleotide binding] 507522000222 Int/Topo IB signature motif; other site 507522000223 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 507522000224 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 507522000225 MASE2 domain; Region: MASE2; pfam05230 507522000226 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522000227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522000228 metal binding site [ion binding]; metal-binding site 507522000229 active site 507522000230 I-site; other site 507522000231 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 507522000232 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 507522000233 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 507522000234 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 507522000235 RES domain; Region: RES; pfam08808 507522000236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 507522000237 Helix-turn-helix domain; Region: HTH_28; pfam13518 507522000238 Helix-turn-helix domain; Region: HTH_28; pfam13518 507522000239 putative transposase OrfB; Reviewed; Region: PHA02517 507522000240 HTH-like domain; Region: HTH_21; pfam13276 507522000241 Integrase core domain; Region: rve; pfam00665 507522000242 Integrase core domain; Region: rve_2; pfam13333 507522000243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522000244 dimerization interface [polypeptide binding]; other site 507522000245 putative DNA binding site [nucleotide binding]; other site 507522000246 putative Zn2+ binding site [ion binding]; other site 507522000247 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 507522000248 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 507522000249 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 507522000250 P loop; other site 507522000251 Nucleotide binding site [chemical binding]; other site 507522000252 DTAP/Switch II; other site 507522000253 Switch I; other site 507522000254 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 507522000255 P loop; other site 507522000256 Nucleotide binding site [chemical binding]; other site 507522000257 DTAP/Switch II; other site 507522000258 Switch I; other site 507522000259 arsenical pump membrane protein; Provisional; Region: PRK15445 507522000260 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 507522000261 transmembrane helices; other site 507522000262 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 507522000263 ArsC family; Region: ArsC; pfam03960 507522000264 catalytic residues [active] 507522000265 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 507522000266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522000267 Coenzyme A binding pocket [chemical binding]; other site 507522000268 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 507522000269 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 507522000270 P loop; other site 507522000271 Nucleotide binding site [chemical binding]; other site 507522000272 DTAP/Switch II; other site 507522000273 Switch I; other site 507522000274 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 507522000275 DTAP/Switch II; other site 507522000276 Switch I; other site 507522000277 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 507522000278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 507522000279 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 507522000280 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 507522000281 DNA binding residues [nucleotide binding] 507522000282 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 507522000283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522000284 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 507522000285 dimerization interface [polypeptide binding]; other site 507522000286 putative DNA binding site [nucleotide binding]; other site 507522000287 putative Zn2+ binding site [ion binding]; other site 507522000288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 507522000289 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 507522000290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 507522000291 small toxic polypeptide; Provisional; Region: PRK09738 507522000292 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 507522000293 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 507522000294 virion protein; Provisional; Region: V; PHA02564 507522000295 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 507522000296 DNA-binding interface [nucleotide binding]; DNA binding site 507522000297 Winged helix-turn helix; Region: HTH_29; pfam13551 507522000298 putative transposase OrfB; Reviewed; Region: PHA02517 507522000299 HTH-like domain; Region: HTH_21; pfam13276 507522000300 Integrase core domain; Region: rve; pfam00665 507522000301 Integrase core domain; Region: rve_3; pfam13683 507522000302 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 507522000303 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 507522000304 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522000305 Protein export membrane protein; Region: SecD_SecF; cl14618 507522000306 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522000307 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522000308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522000309 Ligand Binding Site [chemical binding]; other site 507522000310 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 507522000311 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 507522000312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522000313 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 507522000314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522000315 motif II; other site 507522000316 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 507522000317 Protein of unknown function (DUF330); Region: DUF330; cl01135 507522000318 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 507522000319 mce related protein; Region: MCE; pfam02470 507522000320 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 507522000321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522000322 Walker A/P-loop; other site 507522000323 ATP binding site [chemical binding]; other site 507522000324 Q-loop/lid; other site 507522000325 ABC transporter signature motif; other site 507522000326 Walker B; other site 507522000327 D-loop; other site 507522000328 H-loop/switch region; other site 507522000329 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 507522000330 Permease; Region: Permease; pfam02405 507522000331 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 507522000332 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 507522000333 Ca binding site [ion binding]; other site 507522000334 active site 507522000335 catalytic site [active] 507522000336 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 507522000337 aromatic amino acid transport protein; Region: araaP; TIGR00837 507522000338 hypothetical protein; Provisional; Region: PRK07505 507522000339 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 507522000340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522000341 catalytic residue [active] 507522000342 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 507522000343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000344 putative substrate translocation pore; other site 507522000345 Polymyxin resistance protein PmrD; Region: PmrD; cl12732 507522000346 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 507522000347 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 507522000348 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 507522000349 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 507522000350 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 507522000351 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 507522000352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522000353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522000354 DNA binding site [nucleotide binding] 507522000355 domain linker motif; other site 507522000356 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 507522000357 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 507522000358 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 507522000359 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522000360 active site 507522000361 P-loop; other site 507522000362 phosphorylation site [posttranslational modification] 507522000363 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522000364 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522000365 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 507522000366 beta-galactosidase; Region: BGL; TIGR03356 507522000367 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 507522000368 methionine cluster; other site 507522000369 active site 507522000370 phosphorylation site [posttranslational modification] 507522000371 metal binding site [ion binding]; metal-binding site 507522000372 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 507522000373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 507522000374 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 507522000375 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 507522000376 Autotransporter beta-domain; Region: Autotransporter; pfam03797 507522000377 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 507522000378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 507522000379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 507522000380 gene expression modulator; Provisional; Region: PRK10945 507522000381 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522000382 Abi-like protein; Region: Abi_2; pfam07751 507522000383 CAAX protease self-immunity; Region: Abi; pfam02517 507522000384 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 507522000385 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 507522000386 putative active site [active] 507522000387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522000388 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 507522000389 Walker A/P-loop; other site 507522000390 ATP binding site [chemical binding]; other site 507522000391 Q-loop/lid; other site 507522000392 ABC transporter signature motif; other site 507522000393 Walker B; other site 507522000394 D-loop; other site 507522000395 H-loop/switch region; other site 507522000396 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 507522000397 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522000398 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 507522000399 Restriction endonuclease; Region: Mrr_cat; pfam04471 507522000400 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 507522000401 oligomeric interface; other site 507522000402 putative active site [active] 507522000403 homodimer interface [polypeptide binding]; other site 507522000404 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 507522000405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522000406 ABC transporter signature motif; other site 507522000407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522000408 AAA domain; Region: AAA_13; pfam13166 507522000409 Walker A/P-loop; other site 507522000410 ATP binding site [chemical binding]; other site 507522000411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 507522000412 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 507522000413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522000414 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522000415 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522000416 Staphylococcal nuclease homologues; Region: SNc; smart00318 507522000417 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 507522000418 Catalytic site; other site 507522000419 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 507522000420 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 507522000421 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 507522000422 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 507522000423 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000424 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000425 putative metal binding site [ion binding]; other site 507522000426 Bacterial stress protein; Region: TerD; pfam02342 507522000427 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000428 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000429 putative metal binding site [ion binding]; other site 507522000430 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000431 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000432 putative metal binding site [ion binding]; other site 507522000433 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 507522000434 tellurite resistance protein terB; Region: terB; cd07176 507522000435 putative metal binding site [ion binding]; other site 507522000436 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000437 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000438 putative metal binding site [ion binding]; other site 507522000439 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 507522000440 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000441 putative metal binding site [ion binding]; other site 507522000442 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000443 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000444 putative metal binding site [ion binding]; other site 507522000445 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 507522000446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522000447 active site 507522000448 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 507522000449 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 507522000450 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 507522000451 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 507522000452 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 507522000453 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 507522000454 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 507522000455 metal ion-dependent adhesion site (MIDAS); other site 507522000456 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 507522000457 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 507522000458 putative metal binding site [ion binding]; other site 507522000459 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 507522000460 metal ion-dependent adhesion site (MIDAS); other site 507522000461 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 507522000462 metal ion-dependent adhesion site (MIDAS); other site 507522000463 Protein phosphatase 2C; Region: PP2C_2; pfam13672 507522000464 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 507522000465 substrate binding site [chemical binding]; other site 507522000466 activation loop (A-loop); other site 507522000467 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522000468 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 507522000469 catalytic residues [active] 507522000470 catalytic nucleophile [active] 507522000471 Protein of unknown function, DUF596; Region: DUF596; pfam04591 507522000472 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 507522000473 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 507522000474 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 507522000475 GIY-YIG motif/motif A; other site 507522000476 putative active site [active] 507522000477 putative metal binding site [ion binding]; other site 507522000478 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 507522000479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522000480 Coenzyme A binding pocket [chemical binding]; other site 507522000481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 507522000482 outer membrane protease; Reviewed; Region: PRK10993 507522000483 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 507522000484 DnaA N-terminal domain; Region: DnaA_N; pfam11638 507522000485 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 507522000486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522000487 Walker A motif; other site 507522000488 ATP binding site [chemical binding]; other site 507522000489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 507522000490 Walker B motif; other site 507522000491 arginine finger; other site 507522000492 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 507522000493 DnaA box-binding interface [nucleotide binding]; other site 507522000494 DNA polymerase III subunit beta; Validated; Region: PRK05643 507522000495 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 507522000496 putative DNA binding surface [nucleotide binding]; other site 507522000497 dimer interface [polypeptide binding]; other site 507522000498 beta-clamp/clamp loader binding surface; other site 507522000499 beta-clamp/translesion DNA polymerase binding surface; other site 507522000500 recF protein; Region: recf; TIGR00611 507522000501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522000502 Walker A/P-loop; other site 507522000503 ATP binding site [chemical binding]; other site 507522000504 Q-loop/lid; other site 507522000505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522000506 ABC transporter signature motif; other site 507522000507 Walker B; other site 507522000508 D-loop; other site 507522000509 H-loop/switch region; other site 507522000510 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 507522000511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522000512 Mg2+ binding site [ion binding]; other site 507522000513 G-X-G motif; other site 507522000514 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 507522000515 anchoring element; other site 507522000516 dimer interface [polypeptide binding]; other site 507522000517 ATP binding site [chemical binding]; other site 507522000518 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 507522000519 active site 507522000520 putative metal-binding site [ion binding]; other site 507522000521 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 507522000522 sugar phosphate phosphatase; Provisional; Region: PRK10513 507522000523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522000524 active site 507522000525 motif I; other site 507522000526 motif II; other site 507522000527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522000528 Surface antigen; Region: Bac_surface_Ag; pfam01103 507522000529 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 507522000530 hypothetical protein; Provisional; Region: PRK11616 507522000531 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 507522000532 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 507522000533 putative dimer interface [polypeptide binding]; other site 507522000534 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 507522000535 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 507522000536 putative dimer interface [polypeptide binding]; other site 507522000537 putative transporter; Validated; Region: PRK03818 507522000538 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 507522000539 TrkA-C domain; Region: TrkA_C; pfam02080 507522000540 TrkA-C domain; Region: TrkA_C; pfam02080 507522000541 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 507522000542 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522000543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522000544 DNA-binding site [nucleotide binding]; DNA binding site 507522000545 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 507522000546 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 507522000547 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 507522000548 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522000549 active site turn [active] 507522000550 phosphorylation site [posttranslational modification] 507522000551 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 507522000552 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 507522000553 NAD binding site [chemical binding]; other site 507522000554 sugar binding site [chemical binding]; other site 507522000555 divalent metal binding site [ion binding]; other site 507522000556 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522000557 dimer interface [polypeptide binding]; other site 507522000558 Predicted membrane protein [Function unknown]; Region: COG2149 507522000559 Domain of unknown function (DUF202); Region: DUF202; pfam02656 507522000560 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 507522000561 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 507522000562 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 507522000563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522000564 catalytic residue [active] 507522000565 permease DsdX; Provisional; Region: PRK09921 507522000566 GntP family permease; Region: GntP_permease; pfam02447 507522000567 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 507522000568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000569 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522000570 dimerization interface [polypeptide binding]; other site 507522000571 substrate binding pocket [chemical binding]; other site 507522000572 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 507522000573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000574 putative substrate translocation pore; other site 507522000575 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 507522000576 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 507522000577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522000578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522000579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522000580 Coenzyme A binding pocket [chemical binding]; other site 507522000581 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 507522000582 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522000583 PYR/PP interface [polypeptide binding]; other site 507522000584 dimer interface [polypeptide binding]; other site 507522000585 TPP binding site [chemical binding]; other site 507522000586 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522000587 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 507522000588 TPP-binding site [chemical binding]; other site 507522000589 dimer interface [polypeptide binding]; other site 507522000590 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 507522000591 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 507522000592 putative valine binding site [chemical binding]; other site 507522000593 dimer interface [polypeptide binding]; other site 507522000594 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 507522000595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522000596 active site 507522000597 phosphorylation site [posttranslational modification] 507522000598 intermolecular recognition site; other site 507522000599 dimerization interface [polypeptide binding]; other site 507522000600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522000601 DNA binding residues [nucleotide binding] 507522000602 dimerization interface [polypeptide binding]; other site 507522000603 sensory histidine kinase UhpB; Provisional; Region: PRK11644 507522000604 MASE1; Region: MASE1; pfam05231 507522000605 Histidine kinase; Region: HisKA_3; pfam07730 507522000606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522000607 ATP binding site [chemical binding]; other site 507522000608 Mg2+ binding site [ion binding]; other site 507522000609 G-X-G motif; other site 507522000610 regulatory protein UhpC; Provisional; Region: PRK11663 507522000611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000612 putative substrate translocation pore; other site 507522000613 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 507522000614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000615 putative substrate translocation pore; other site 507522000616 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 507522000617 Predicted transcriptional regulator [Transcription]; Region: COG2944 507522000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522000619 non-specific DNA binding site [nucleotide binding]; other site 507522000620 salt bridge; other site 507522000621 sequence-specific DNA binding site [nucleotide binding]; other site 507522000622 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 507522000623 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 507522000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000625 putative substrate translocation pore; other site 507522000626 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 507522000627 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 507522000628 methionine cluster; other site 507522000629 active site 507522000630 phosphorylation site [posttranslational modification] 507522000631 metal binding site [ion binding]; metal-binding site 507522000632 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522000633 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522000634 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522000635 active site 507522000636 P-loop; other site 507522000637 phosphorylation site [posttranslational modification] 507522000638 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522000639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522000640 DNA binding site [nucleotide binding] 507522000641 domain linker motif; other site 507522000642 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 507522000643 ligand binding site [chemical binding]; other site 507522000644 benzoate transport; Region: 2A0115; TIGR00895 507522000645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000646 putative substrate translocation pore; other site 507522000647 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 507522000648 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 507522000649 putative active site [active] 507522000650 Fe(II) binding site [ion binding]; other site 507522000651 putative dimer interface [polypeptide binding]; other site 507522000652 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 507522000653 putative dimer interface [polypeptide binding]; other site 507522000654 putative N- and C-terminal domain interface [polypeptide binding]; other site 507522000655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522000656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000657 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 507522000658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000659 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 507522000660 putative dimerization interface [polypeptide binding]; other site 507522000661 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 507522000662 hypothetical protein; Provisional; Region: PRK09262 507522000663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 507522000664 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 507522000665 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 507522000666 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522000667 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 507522000668 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522000669 active site turn [active] 507522000670 phosphorylation site [posttranslational modification] 507522000671 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522000672 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 507522000673 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 507522000674 putative active site [active] 507522000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000676 putative substrate translocation pore; other site 507522000677 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 507522000678 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 507522000679 Protein export membrane protein; Region: SecD_SecF; cl14618 507522000680 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 507522000681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522000682 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522000683 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522000684 Coenzyme A binding pocket [chemical binding]; other site 507522000685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522000686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522000687 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 507522000688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522000689 putative substrate translocation pore; other site 507522000690 transcriptional regulator; Provisional; Region: PRK10632 507522000691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522000692 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 507522000693 putative effector binding pocket; other site 507522000694 putative dimerization interface [polypeptide binding]; other site 507522000695 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 507522000696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 507522000697 SnoaL-like domain; Region: SnoaL_2; pfam12680 507522000698 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 507522000699 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 507522000700 Cupin; Region: Cupin_6; pfam12852 507522000701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522000703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000704 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 507522000705 lipoprotein, YaeC family; Region: TIGR00363 507522000706 EamA-like transporter family; Region: EamA; pfam00892 507522000707 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 507522000708 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 507522000709 dimer interface [polypeptide binding]; other site 507522000710 ADP-ribose binding site [chemical binding]; other site 507522000711 active site 507522000712 nudix motif; other site 507522000713 metal binding site [ion binding]; metal-binding site 507522000714 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 507522000715 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 507522000716 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 507522000717 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 507522000718 conserved cys residue [active] 507522000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522000721 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 507522000722 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 507522000723 putative NAD(P) binding site [chemical binding]; other site 507522000724 putative substrate binding site [chemical binding]; other site 507522000725 catalytic Zn binding site [ion binding]; other site 507522000726 structural Zn binding site [ion binding]; other site 507522000727 dimer interface [polypeptide binding]; other site 507522000728 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 507522000729 Uncharacterized conserved protein [Function unknown]; Region: COG1359 507522000730 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 507522000731 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 507522000732 putative NAD(P) binding site [chemical binding]; other site 507522000733 dimer interface [polypeptide binding]; other site 507522000734 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 507522000735 putative transporter; Provisional; Region: PRK11462 507522000736 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522000737 putative alpha-glucosidase; Provisional; Region: PRK10658 507522000738 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 507522000739 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 507522000740 active site 507522000741 homotrimer interface [polypeptide binding]; other site 507522000742 catalytic site [active] 507522000743 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 507522000744 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522000745 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522000746 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522000747 putative active site [active] 507522000748 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 507522000749 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 507522000750 NAD(P) binding site [chemical binding]; other site 507522000751 LDH/MDH dimer interface [polypeptide binding]; other site 507522000752 substrate binding site [chemical binding]; other site 507522000753 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522000754 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 507522000755 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522000756 active site turn [active] 507522000757 phosphorylation site [posttranslational modification] 507522000758 AsmA family; Region: AsmA; pfam05170 507522000759 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 507522000760 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 507522000761 glycerol kinase; Provisional; Region: glpK; PRK00047 507522000762 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 507522000763 N- and C-terminal domain interface [polypeptide binding]; other site 507522000764 active site 507522000765 MgATP binding site [chemical binding]; other site 507522000766 catalytic site [active] 507522000767 metal binding site [ion binding]; metal-binding site 507522000768 glycerol binding site [chemical binding]; other site 507522000769 homotetramer interface [polypeptide binding]; other site 507522000770 homodimer interface [polypeptide binding]; other site 507522000771 FBP binding site [chemical binding]; other site 507522000772 protein IIAGlc interface [polypeptide binding]; other site 507522000773 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 507522000774 amphipathic channel; other site 507522000775 Asn-Pro-Ala signature motifs; other site 507522000776 septal ring assembly protein ZapB; Provisional; Region: PRK15422 507522000777 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 507522000778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522000779 substrate binding pocket [chemical binding]; other site 507522000780 membrane-bound complex binding site; other site 507522000781 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 507522000782 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 507522000783 transmembrane helices; other site 507522000784 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522000785 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 507522000786 triosephosphate isomerase; Provisional; Region: PRK14567 507522000787 substrate binding site [chemical binding]; other site 507522000788 dimer interface [polypeptide binding]; other site 507522000789 catalytic triad [active] 507522000790 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 507522000791 Predicted membrane protein [Function unknown]; Region: COG3152 507522000792 ferredoxin-NADP reductase; Provisional; Region: PRK10926 507522000793 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 507522000794 FAD binding pocket [chemical binding]; other site 507522000795 FAD binding motif [chemical binding]; other site 507522000796 phosphate binding motif [ion binding]; other site 507522000797 beta-alpha-beta structure motif; other site 507522000798 NAD binding pocket [chemical binding]; other site 507522000799 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 507522000800 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 507522000801 putative active site [active] 507522000802 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 507522000803 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 507522000804 generic binding surface II; other site 507522000805 ssDNA binding site; other site 507522000806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522000807 ATP binding site [chemical binding]; other site 507522000808 putative Mg++ binding site [ion binding]; other site 507522000809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522000810 nucleotide binding region [chemical binding]; other site 507522000811 ATP-binding site [chemical binding]; other site 507522000812 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 507522000813 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 507522000814 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 507522000815 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 507522000816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522000817 Zn2+ binding site [ion binding]; other site 507522000818 Mg2+ binding site [ion binding]; other site 507522000819 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 507522000820 synthetase active site [active] 507522000821 NTP binding site [chemical binding]; other site 507522000822 metal binding site [ion binding]; metal-binding site 507522000823 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 507522000824 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 507522000825 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 507522000826 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 507522000827 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 507522000828 catalytic site [active] 507522000829 G-X2-G-X-G-K; other site 507522000830 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 507522000831 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 507522000832 nucleotide binding pocket [chemical binding]; other site 507522000833 K-X-D-G motif; other site 507522000834 catalytic site [active] 507522000835 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 507522000836 Predicted membrane protein [Function unknown]; Region: COG2860 507522000837 UPF0126 domain; Region: UPF0126; pfam03458 507522000838 UPF0126 domain; Region: UPF0126; pfam03458 507522000839 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 507522000840 putative ion selectivity filter; other site 507522000841 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 507522000842 putative pore gating glutamate residue; other site 507522000843 hypothetical protein; Provisional; Region: PRK11820 507522000844 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 507522000845 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 507522000846 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 507522000847 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 507522000848 putative acyl-acceptor binding pocket; other site 507522000849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 507522000850 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 507522000851 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522000852 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 507522000853 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522000854 Walker A/P-loop; other site 507522000855 ATP binding site [chemical binding]; other site 507522000856 Q-loop/lid; other site 507522000857 ABC transporter signature motif; other site 507522000858 Walker B; other site 507522000859 D-loop; other site 507522000860 H-loop/switch region; other site 507522000861 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 507522000862 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522000863 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 507522000864 ribonuclease PH; Reviewed; Region: rph; PRK00173 507522000865 Ribonuclease PH; Region: RNase_PH_bact; cd11362 507522000866 hexamer interface [polypeptide binding]; other site 507522000867 active site 507522000868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522000869 active site 507522000870 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 507522000871 division inhibitor protein; Provisional; Region: slmA; PRK09480 507522000872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522000873 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 507522000874 trimer interface [polypeptide binding]; other site 507522000875 active site 507522000876 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 507522000877 Flavoprotein; Region: Flavoprotein; pfam02441 507522000878 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 507522000879 hypothetical protein; Reviewed; Region: PRK00024 507522000880 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 507522000881 MPN+ (JAMM) motif; other site 507522000882 Zinc-binding site [ion binding]; other site 507522000883 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 507522000884 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 507522000885 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 507522000886 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 507522000887 DNA binding site [nucleotide binding] 507522000888 catalytic residue [active] 507522000889 H2TH interface [polypeptide binding]; other site 507522000890 putative catalytic residues [active] 507522000891 turnover-facilitating residue; other site 507522000892 intercalation triad [nucleotide binding]; other site 507522000893 8OG recognition residue [nucleotide binding]; other site 507522000894 putative reading head residues; other site 507522000895 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 507522000896 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 507522000897 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 507522000898 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 507522000899 active site 507522000900 (T/H)XGH motif; other site 507522000901 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 507522000902 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 507522000903 putative metal binding site; other site 507522000904 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 507522000905 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 507522000906 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 507522000907 putative glycosyl transferase; Provisional; Region: PRK10073 507522000908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 507522000909 active site 507522000910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522000911 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 507522000912 putative ADP-binding pocket [chemical binding]; other site 507522000913 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 507522000914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522000915 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 507522000916 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 507522000917 putative active site [active] 507522000918 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 507522000919 putative active site [active] 507522000920 putative catalytic site [active] 507522000921 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 507522000922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 507522000923 O-Antigen ligase; Region: Wzy_C; pfam04932 507522000924 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 507522000925 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 507522000926 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 507522000927 putative active site [active] 507522000928 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 507522000929 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 507522000930 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 507522000931 putative active site [active] 507522000932 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 507522000933 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 507522000934 NADP binding site [chemical binding]; other site 507522000935 homopentamer interface [polypeptide binding]; other site 507522000936 substrate binding site [chemical binding]; other site 507522000937 active site 507522000938 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 507522000939 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 507522000940 substrate-cofactor binding pocket; other site 507522000941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522000942 catalytic residue [active] 507522000943 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 507522000944 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 507522000945 NAD(P) binding site [chemical binding]; other site 507522000946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 507522000947 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 507522000948 putative metal binding site; other site 507522000949 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 507522000950 NodB motif; other site 507522000951 putative active site [active] 507522000952 putative catalytic site [active] 507522000953 Zn binding site [ion binding]; other site 507522000954 AmiB activator; Provisional; Region: PRK11637 507522000955 Vps51/Vps67; Region: Vps51; pfam08700 507522000956 Peptidase family M23; Region: Peptidase_M23; pfam01551 507522000957 phosphoglyceromutase; Provisional; Region: PRK05434 507522000958 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 507522000959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 507522000960 active site residue [active] 507522000961 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 507522000962 GSH binding site [chemical binding]; other site 507522000963 catalytic residues [active] 507522000964 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 507522000965 SecA binding site; other site 507522000966 Preprotein binding site; other site 507522000967 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 507522000968 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 507522000969 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 507522000970 serine acetyltransferase; Provisional; Region: cysE; PRK11132 507522000971 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 507522000972 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 507522000973 trimer interface [polypeptide binding]; other site 507522000974 active site 507522000975 substrate binding site [chemical binding]; other site 507522000976 CoA binding site [chemical binding]; other site 507522000977 putative rRNA methylase; Provisional; Region: PRK10358 507522000978 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 507522000979 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 507522000980 active site 507522000981 substrate binding site [chemical binding]; other site 507522000982 FMN binding site [chemical binding]; other site 507522000983 putative catalytic residues [active] 507522000984 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 507522000985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522000986 DNA-binding site [nucleotide binding]; DNA binding site 507522000987 FCD domain; Region: FCD; pfam07729 507522000988 L-lactate permease; Provisional; Region: PRK10420 507522000989 glycolate transporter; Provisional; Region: PRK09695 507522000990 hypothetical protein; Provisional; Region: PRK11020 507522000991 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 507522000992 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 507522000993 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 507522000994 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522000995 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522000996 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 507522000997 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 507522000998 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 507522000999 active site 507522001000 P-loop; other site 507522001001 phosphorylation site [posttranslational modification] 507522001002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522001003 active site 507522001004 phosphorylation site [posttranslational modification] 507522001005 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 507522001006 Chorismate mutase type II; Region: CM_2; cl00693 507522001007 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 507522001008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522001009 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522001010 putative glutathione S-transferase; Provisional; Region: PRK10357 507522001011 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 507522001012 putative C-terminal domain interface [polypeptide binding]; other site 507522001013 putative GSH binding site (G-site) [chemical binding]; other site 507522001014 putative dimer interface [polypeptide binding]; other site 507522001015 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 507522001016 dimer interface [polypeptide binding]; other site 507522001017 N-terminal domain interface [polypeptide binding]; other site 507522001018 putative substrate binding pocket (H-site) [chemical binding]; other site 507522001019 selenocysteine synthase; Provisional; Region: PRK04311 507522001020 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 507522001021 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 507522001022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522001023 catalytic residue [active] 507522001024 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 507522001025 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 507522001026 G1 box; other site 507522001027 putative GEF interaction site [polypeptide binding]; other site 507522001028 GTP/Mg2+ binding site [chemical binding]; other site 507522001029 Switch I region; other site 507522001030 G2 box; other site 507522001031 G3 box; other site 507522001032 Switch II region; other site 507522001033 G4 box; other site 507522001034 G5 box; other site 507522001035 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 507522001036 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 507522001037 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 507522001038 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 507522001039 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 507522001040 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 507522001041 intersubunit interface [polypeptide binding]; other site 507522001042 active site 507522001043 Zn2+ binding site [ion binding]; other site 507522001044 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 507522001045 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 507522001046 AP (apurinic/apyrimidinic) site pocket; other site 507522001047 DNA interaction; other site 507522001048 Metal-binding active site; metal-binding site 507522001049 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 507522001050 active site 507522001051 dimer interface [polypeptide binding]; other site 507522001052 magnesium binding site [ion binding]; other site 507522001053 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 507522001054 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 507522001055 putative N- and C-terminal domain interface [polypeptide binding]; other site 507522001056 putative active site [active] 507522001057 MgATP binding site [chemical binding]; other site 507522001058 catalytic site [active] 507522001059 metal binding site [ion binding]; metal-binding site 507522001060 putative xylulose binding site [chemical binding]; other site 507522001061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001062 D-galactonate transporter; Region: 2A0114; TIGR00893 507522001063 putative substrate translocation pore; other site 507522001064 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 507522001065 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 507522001066 Transcriptional regulator [Transcription]; Region: IclR; COG1414 507522001067 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522001068 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522001069 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 507522001070 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 507522001071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522001072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522001073 homodimer interface [polypeptide binding]; other site 507522001074 catalytic residue [active] 507522001075 alpha-amylase; Reviewed; Region: malS; PRK09505 507522001076 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 507522001077 active site 507522001078 catalytic site [active] 507522001079 hypothetical protein; Provisional; Region: PRK10356 507522001080 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 507522001081 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 507522001082 putative dimerization interface [polypeptide binding]; other site 507522001083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522001084 putative ligand binding site [chemical binding]; other site 507522001085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522001086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522001087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522001088 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522001089 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522001090 TM-ABC transporter signature motif; other site 507522001091 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 507522001092 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522001093 Walker A/P-loop; other site 507522001094 ATP binding site [chemical binding]; other site 507522001095 Q-loop/lid; other site 507522001096 ABC transporter signature motif; other site 507522001097 Walker B; other site 507522001098 D-loop; other site 507522001099 H-loop/switch region; other site 507522001100 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522001101 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 507522001102 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 507522001103 putative ligand binding site [chemical binding]; other site 507522001104 xylose isomerase; Provisional; Region: PRK05474 507522001105 xylose isomerase; Region: xylose_isom_A; TIGR02630 507522001106 xylulokinase; Provisional; Region: PRK15027 507522001107 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 507522001108 N- and C-terminal domain interface [polypeptide binding]; other site 507522001109 active site 507522001110 MgATP binding site [chemical binding]; other site 507522001111 catalytic site [active] 507522001112 metal binding site [ion binding]; metal-binding site 507522001113 xylulose binding site [chemical binding]; other site 507522001114 homodimer interface [polypeptide binding]; other site 507522001115 hypothetical protein; Provisional; Region: PRK11403 507522001116 yiaA/B two helix domain; Region: YiaAB; cl01759 507522001117 hypothetical protein; Provisional; Region: PRK11383 507522001118 yiaA/B two helix domain; Region: YiaAB; pfam05360 507522001119 yiaA/B two helix domain; Region: YiaAB; pfam05360 507522001120 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 507522001121 Acyltransferase family; Region: Acyl_transf_3; pfam01757 507522001122 YsaB-like lipoprotein; Region: YsaB; pfam13983 507522001123 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 507522001124 dimer interface [polypeptide binding]; other site 507522001125 motif 1; other site 507522001126 active site 507522001127 motif 2; other site 507522001128 motif 3; other site 507522001129 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 507522001130 DALR anticodon binding domain; Region: DALR_1; pfam05746 507522001131 Hok/gef family; Region: HOK_GEF; cl11494 507522001132 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 507522001133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522001134 Walker A/P-loop; other site 507522001135 ATP binding site [chemical binding]; other site 507522001136 Q-loop/lid; other site 507522001137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522001138 ABC transporter signature motif; other site 507522001139 Walker B; other site 507522001140 D-loop; other site 507522001141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522001142 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522001143 DNA-binding site [nucleotide binding]; DNA binding site 507522001144 RNA-binding motif; other site 507522001145 Predicted transcriptional regulator [Transcription]; Region: COG2944 507522001146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522001147 salt bridge; other site 507522001148 non-specific DNA binding site [nucleotide binding]; other site 507522001149 sequence-specific DNA binding site [nucleotide binding]; other site 507522001150 benzoate transport; Region: 2A0115; TIGR00895 507522001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001152 putative substrate translocation pore; other site 507522001153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001154 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 507522001155 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 507522001156 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 507522001157 dimerization interface [polypeptide binding]; other site 507522001158 ligand binding site [chemical binding]; other site 507522001159 NADP binding site [chemical binding]; other site 507522001160 catalytic site [active] 507522001161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001162 D-galactonate transporter; Region: 2A0114; TIGR00893 507522001163 putative substrate translocation pore; other site 507522001164 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522001165 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 507522001166 substrate binding site [chemical binding]; other site 507522001167 ATP binding site [chemical binding]; other site 507522001168 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 507522001169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522001170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522001171 DNA binding site [nucleotide binding] 507522001172 domain linker motif; other site 507522001173 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 507522001174 putative dimerization interface [polypeptide binding]; other site 507522001175 putative ligand binding site [chemical binding]; other site 507522001176 putative outer membrane lipoprotein; Provisional; Region: PRK10510 507522001177 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522001178 ligand binding site [chemical binding]; other site 507522001179 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 507522001180 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 507522001181 molybdopterin cofactor binding site [chemical binding]; other site 507522001182 substrate binding site [chemical binding]; other site 507522001183 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 507522001184 molybdopterin cofactor binding site; other site 507522001185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522001186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522001187 Coenzyme A binding pocket [chemical binding]; other site 507522001188 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 507522001189 Autotransporter beta-domain; Region: Autotransporter; cl17461 507522001190 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 507522001191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001192 putative substrate translocation pore; other site 507522001193 phosphoethanolamine transferase; Provisional; Region: PRK11560 507522001194 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 507522001195 Sulfatase; Region: Sulfatase; pfam00884 507522001196 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 507522001197 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 507522001198 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 507522001199 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 507522001200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 507522001201 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522001202 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 507522001203 peptide binding site [polypeptide binding]; other site 507522001204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001206 dimer interface [polypeptide binding]; other site 507522001207 conserved gate region; other site 507522001208 putative PBP binding loops; other site 507522001209 ABC-ATPase subunit interface; other site 507522001210 dipeptide transporter; Provisional; Region: PRK10913 507522001211 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001213 putative PBP binding loops; other site 507522001214 dimer interface [polypeptide binding]; other site 507522001215 ABC-ATPase subunit interface; other site 507522001216 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 507522001217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522001218 Walker A/P-loop; other site 507522001219 ATP binding site [chemical binding]; other site 507522001220 Q-loop/lid; other site 507522001221 ABC transporter signature motif; other site 507522001222 Walker B; other site 507522001223 D-loop; other site 507522001224 H-loop/switch region; other site 507522001225 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522001226 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 507522001227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522001228 Walker A/P-loop; other site 507522001229 ATP binding site [chemical binding]; other site 507522001230 Q-loop/lid; other site 507522001231 ABC transporter signature motif; other site 507522001232 Walker B; other site 507522001233 D-loop; other site 507522001234 H-loop/switch region; other site 507522001235 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522001236 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 507522001237 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 507522001238 P-loop; other site 507522001239 Magnesium ion binding site [ion binding]; other site 507522001240 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 507522001241 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 507522001242 DXD motif; other site 507522001243 PilZ domain; Region: PilZ; pfam07238 507522001244 cellulose synthase regulator protein; Provisional; Region: PRK11114 507522001245 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 507522001246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522001247 TPR motif; other site 507522001248 binding surface 507522001249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 507522001250 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 507522001251 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 507522001252 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 507522001253 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 507522001254 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 507522001255 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 507522001256 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 507522001257 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 507522001258 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 507522001259 cell division protein; Provisional; Region: PRK10037 507522001260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522001261 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 507522001262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 507522001263 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 507522001264 DXD motif; other site 507522001265 PilZ domain; Region: PilZ; pfam07238 507522001266 cellulose synthase regulator protein; Provisional; Region: PRK11114 507522001267 endo-1,4-D-glucanase; Provisional; Region: PRK11097 507522001268 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 507522001269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522001270 TPR motif; other site 507522001271 binding surface 507522001272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522001273 binding surface 507522001274 TPR motif; other site 507522001275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522001276 binding surface 507522001277 TPR motif; other site 507522001278 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 507522001279 putative diguanylate cyclase; Provisional; Region: PRK13561 507522001280 HAMP domain; Region: HAMP; pfam00672 507522001281 dimerization interface [polypeptide binding]; other site 507522001282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522001283 metal binding site [ion binding]; metal-binding site 507522001284 active site 507522001285 I-site; other site 507522001286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522001287 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 507522001288 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 507522001289 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 507522001290 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 507522001291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522001292 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 507522001293 substrate binding site [chemical binding]; other site 507522001294 ATP binding site [chemical binding]; other site 507522001295 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 507522001296 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 507522001297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001298 metabolite-proton symporter; Region: 2A0106; TIGR00883 507522001299 putative substrate translocation pore; other site 507522001300 inner membrane protein YhjD; Region: TIGR00766 507522001301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522001302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522001303 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522001304 putative effector binding pocket; other site 507522001305 putative dimerization interface [polypeptide binding]; other site 507522001306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 507522001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522001308 NAD(P) binding site [chemical binding]; other site 507522001309 active site 507522001310 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 507522001311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522001312 trehalase; Provisional; Region: treF; PRK13270 507522001313 Trehalase; Region: Trehalase; pfam01204 507522001314 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 507522001315 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 507522001316 putative active site [active] 507522001317 metal binding site [ion binding]; metal-binding site 507522001318 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522001319 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 507522001320 putative C-terminal domain interface [polypeptide binding]; other site 507522001321 putative GSH binding site (G-site) [chemical binding]; other site 507522001322 putative dimer interface [polypeptide binding]; other site 507522001323 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 507522001324 putative N-terminal domain interface [polypeptide binding]; other site 507522001325 putative dimer interface [polypeptide binding]; other site 507522001326 putative substrate binding pocket (H-site) [chemical binding]; other site 507522001327 glutathione reductase; Validated; Region: PRK06116 507522001328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522001329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522001330 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 507522001331 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 507522001332 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 507522001333 active site 507522001334 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 507522001335 oligopeptidase A; Provisional; Region: PRK10911 507522001336 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 507522001337 active site 507522001338 Zn binding site [ion binding]; other site 507522001339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522001340 S-adenosylmethionine binding site [chemical binding]; other site 507522001341 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 507522001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001343 putative substrate translocation pore; other site 507522001344 POT family; Region: PTR2; pfam00854 507522001345 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522001346 Ligand Binding Site [chemical binding]; other site 507522001347 universal stress protein UspB; Provisional; Region: PRK04960 507522001348 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 507522001349 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 507522001350 Predicted flavoproteins [General function prediction only]; Region: COG2081 507522001351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522001352 Propionate catabolism activator; Region: PrpR_N; pfam06506 507522001353 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 507522001354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522001355 Walker A motif; other site 507522001356 ATP binding site [chemical binding]; other site 507522001357 Walker B motif; other site 507522001358 arginine finger; other site 507522001359 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522001360 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 507522001361 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522001362 active site 507522001363 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 507522001364 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522001365 transmembrane helices; other site 507522001366 hypothetical protein; Validated; Region: PRK06201 507522001367 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 507522001368 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 507522001369 ligand binding site [chemical binding]; other site 507522001370 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 507522001371 NAD binding site [chemical binding]; other site 507522001372 dimerization interface [polypeptide binding]; other site 507522001373 catalytic site [active] 507522001374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522001375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522001376 FOG: CBS domain [General function prediction only]; Region: COG0517 507522001377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 507522001378 Divalent cation transporter; Region: MgtE; pfam01769 507522001379 nickel responsive regulator; Provisional; Region: PRK02967 507522001380 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 507522001381 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 507522001382 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522001383 Walker A/P-loop; other site 507522001384 ATP binding site [chemical binding]; other site 507522001385 Q-loop/lid; other site 507522001386 ABC transporter signature motif; other site 507522001387 Walker B; other site 507522001388 D-loop; other site 507522001389 H-loop/switch region; other site 507522001390 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 507522001391 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522001392 Walker A/P-loop; other site 507522001393 ATP binding site [chemical binding]; other site 507522001394 Q-loop/lid; other site 507522001395 ABC transporter signature motif; other site 507522001396 Walker B; other site 507522001397 D-loop; other site 507522001398 H-loop/switch region; other site 507522001399 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 507522001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001401 dimer interface [polypeptide binding]; other site 507522001402 conserved gate region; other site 507522001403 putative PBP binding loops; other site 507522001404 ABC-ATPase subunit interface; other site 507522001405 nickel transporter permease NikB; Provisional; Region: PRK10352 507522001406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001407 dimer interface [polypeptide binding]; other site 507522001408 conserved gate region; other site 507522001409 putative PBP binding loops; other site 507522001410 ABC-ATPase subunit interface; other site 507522001411 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 507522001412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522001413 substrate binding site [chemical binding]; other site 507522001414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522001415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522001416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522001417 dimerization interface [polypeptide binding]; other site 507522001418 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 507522001419 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 507522001420 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 507522001421 inhibitor-cofactor binding pocket; inhibition site 507522001422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522001423 catalytic residue [active] 507522001424 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 507522001425 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 507522001426 Ligand binding site; other site 507522001427 Putative Catalytic site; other site 507522001428 DXD motif; other site 507522001429 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 507522001430 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 507522001431 substrate binding site [chemical binding]; other site 507522001432 cosubstrate binding site; other site 507522001433 catalytic site [active] 507522001434 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 507522001435 active site 507522001436 hexamer interface [polypeptide binding]; other site 507522001437 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 507522001438 NAD binding site [chemical binding]; other site 507522001439 substrate binding site [chemical binding]; other site 507522001440 active site 507522001441 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 507522001442 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 507522001443 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 507522001444 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 507522001445 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 507522001446 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 507522001447 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 507522001448 Domain of unknown function DUF20; Region: UPF0118; pfam01594 507522001449 major facilitator superfamily transporter; Provisional; Region: PRK05122 507522001450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001451 putative substrate translocation pore; other site 507522001452 hypothetical protein; Provisional; Region: PRK11615 507522001453 hypothetical protein; Provisional; Region: PRK11212 507522001454 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 507522001455 CPxP motif; other site 507522001456 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 507522001457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 507522001458 metal-binding site [ion binding] 507522001459 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522001460 Soluble P-type ATPase [General function prediction only]; Region: COG4087 507522001461 Predicted membrane protein [Function unknown]; Region: COG3714 507522001462 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 507522001463 hypothetical protein; Provisional; Region: PRK10910 507522001464 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 507522001465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522001466 S-adenosylmethionine binding site [chemical binding]; other site 507522001467 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 507522001468 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 507522001469 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 507522001470 P loop; other site 507522001471 GTP binding site [chemical binding]; other site 507522001472 cell division protein FtsE; Provisional; Region: PRK10908 507522001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522001474 Walker A/P-loop; other site 507522001475 ATP binding site [chemical binding]; other site 507522001476 Q-loop/lid; other site 507522001477 ABC transporter signature motif; other site 507522001478 Walker B; other site 507522001479 D-loop; other site 507522001480 H-loop/switch region; other site 507522001481 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 507522001482 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 507522001483 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 507522001484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 507522001485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 507522001486 DNA binding residues [nucleotide binding] 507522001487 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522001488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522001489 DNA-binding site [nucleotide binding]; DNA binding site 507522001490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522001491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522001492 homodimer interface [polypeptide binding]; other site 507522001493 catalytic residue [active] 507522001494 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 507522001495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522001496 inhibitor-cofactor binding pocket; inhibition site 507522001497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522001498 catalytic residue [active] 507522001499 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 507522001500 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 507522001501 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 507522001502 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 507522001503 dimerization interface [polypeptide binding]; other site 507522001504 ligand binding site [chemical binding]; other site 507522001505 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 507522001506 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 507522001507 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 507522001508 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 507522001509 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 507522001510 dimerization interface [polypeptide binding]; other site 507522001511 ligand binding site [chemical binding]; other site 507522001512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522001513 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 507522001514 TM-ABC transporter signature motif; other site 507522001515 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 507522001516 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 507522001517 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 507522001518 TM-ABC transporter signature motif; other site 507522001519 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 507522001520 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 507522001521 Walker A/P-loop; other site 507522001522 ATP binding site [chemical binding]; other site 507522001523 Q-loop/lid; other site 507522001524 ABC transporter signature motif; other site 507522001525 Walker B; other site 507522001526 D-loop; other site 507522001527 H-loop/switch region; other site 507522001528 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 507522001529 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 507522001530 Walker A/P-loop; other site 507522001531 ATP binding site [chemical binding]; other site 507522001532 Q-loop/lid; other site 507522001533 ABC transporter signature motif; other site 507522001534 Walker B; other site 507522001535 D-loop; other site 507522001536 H-loop/switch region; other site 507522001537 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 507522001538 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 507522001539 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 507522001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001541 putative PBP binding loops; other site 507522001542 dimer interface [polypeptide binding]; other site 507522001543 ABC-ATPase subunit interface; other site 507522001544 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522001545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522001546 dimer interface [polypeptide binding]; other site 507522001547 conserved gate region; other site 507522001548 putative PBP binding loops; other site 507522001549 ABC-ATPase subunit interface; other site 507522001550 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 507522001551 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 507522001552 Walker A/P-loop; other site 507522001553 ATP binding site [chemical binding]; other site 507522001554 Q-loop/lid; other site 507522001555 ABC transporter signature motif; other site 507522001556 Walker B; other site 507522001557 D-loop; other site 507522001558 H-loop/switch region; other site 507522001559 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 507522001560 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 507522001561 putative active site [active] 507522001562 catalytic site [active] 507522001563 putative metal binding site [ion binding]; other site 507522001564 Protein of unknown function (DUF2756); Region: DUF2756; cl08110 507522001565 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 507522001566 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 507522001567 putative acetyltransferase YhhY; Provisional; Region: PRK10140 507522001568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522001569 Coenzyme A binding pocket [chemical binding]; other site 507522001570 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 507522001571 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 507522001572 putative oxidoreductase; Provisional; Region: PRK10206 507522001573 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522001574 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522001575 Pirin-related protein [General function prediction only]; Region: COG1741 507522001576 Pirin; Region: Pirin; pfam02678 507522001577 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 507522001578 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522001579 DNA binding site [nucleotide binding] 507522001580 domain linker motif; other site 507522001581 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 507522001582 putative ligand binding site [chemical binding]; other site 507522001583 putative dimerization interface [polypeptide binding]; other site 507522001584 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 507522001585 ATP-binding site [chemical binding]; other site 507522001586 Gluconate-6-phosphate binding site [chemical binding]; other site 507522001587 low affinity gluconate transporter; Provisional; Region: PRK10472 507522001588 gluconate transporter; Region: gntP; TIGR00791 507522001589 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 507522001590 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 507522001591 glycogen branching enzyme; Provisional; Region: PRK05402 507522001592 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 507522001593 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 507522001594 active site 507522001595 catalytic site [active] 507522001596 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 507522001597 glycogen debranching enzyme; Provisional; Region: PRK03705 507522001598 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 507522001599 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 507522001600 active site 507522001601 catalytic site [active] 507522001602 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 507522001603 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 507522001604 ligand binding site; other site 507522001605 oligomer interface; other site 507522001606 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 507522001607 dimer interface [polypeptide binding]; other site 507522001608 N-terminal domain interface [polypeptide binding]; other site 507522001609 sulfate 1 binding site; other site 507522001610 glycogen synthase; Provisional; Region: glgA; PRK00654 507522001611 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 507522001612 ADP-binding pocket [chemical binding]; other site 507522001613 homodimer interface [polypeptide binding]; other site 507522001614 glycogen phosphorylase; Provisional; Region: PRK14986 507522001615 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 507522001616 homodimer interface [polypeptide binding]; other site 507522001617 active site pocket [active] 507522001618 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 507522001619 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 507522001620 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 507522001621 active site residue [active] 507522001622 intramembrane serine protease GlpG; Provisional; Region: PRK10907 507522001623 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 507522001624 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 507522001625 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 507522001626 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 507522001627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522001628 transcriptional regulator MalT; Provisional; Region: PRK04841 507522001629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522001630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522001631 DNA binding residues [nucleotide binding] 507522001632 dimerization interface [polypeptide binding]; other site 507522001633 maltodextrin phosphorylase; Provisional; Region: PRK14985 507522001634 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 507522001635 homodimer interface [polypeptide binding]; other site 507522001636 active site pocket [active] 507522001637 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 507522001638 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 507522001639 high-affinity gluconate transporter; Provisional; Region: PRK14984 507522001640 gluconate transporter; Region: gntP; TIGR00791 507522001641 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 507522001642 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 507522001643 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 507522001644 DNA utilization protein GntX; Provisional; Region: PRK11595 507522001645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522001646 active site 507522001647 carboxylesterase BioH; Provisional; Region: PRK10349 507522001648 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 507522001649 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522001650 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 507522001651 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 507522001652 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 507522001653 G1 box; other site 507522001654 GTP/Mg2+ binding site [chemical binding]; other site 507522001655 Switch I region; other site 507522001656 G2 box; other site 507522001657 G3 box; other site 507522001658 Switch II region; other site 507522001659 G4 box; other site 507522001660 G5 box; other site 507522001661 Nucleoside recognition; Region: Gate; pfam07670 507522001662 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 507522001663 Nucleoside recognition; Region: Gate; pfam07670 507522001664 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 507522001665 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 507522001666 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 507522001667 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 507522001668 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 507522001669 RNA binding site [nucleotide binding]; other site 507522001670 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 507522001671 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 507522001672 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 507522001673 osmolarity response regulator; Provisional; Region: ompR; PRK09468 507522001674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522001675 active site 507522001676 phosphorylation site [posttranslational modification] 507522001677 intermolecular recognition site; other site 507522001678 dimerization interface [polypeptide binding]; other site 507522001679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522001680 DNA binding site [nucleotide binding] 507522001681 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 507522001682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522001683 dimerization interface [polypeptide binding]; other site 507522001684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522001685 dimer interface [polypeptide binding]; other site 507522001686 phosphorylation site [posttranslational modification] 507522001687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522001688 ATP binding site [chemical binding]; other site 507522001689 Mg2+ binding site [ion binding]; other site 507522001690 G-X-G motif; other site 507522001691 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 507522001692 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 507522001693 active site 507522001694 substrate-binding site [chemical binding]; other site 507522001695 metal-binding site [ion binding] 507522001696 ATP binding site [chemical binding]; other site 507522001697 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 507522001698 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 507522001699 dimerization interface [polypeptide binding]; other site 507522001700 domain crossover interface; other site 507522001701 redox-dependent activation switch; other site 507522001702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522001703 RNA binding surface [nucleotide binding]; other site 507522001704 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 507522001705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522001706 motif II; other site 507522001707 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 507522001708 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 507522001709 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 507522001710 ADP-ribose binding site [chemical binding]; other site 507522001711 dimer interface [polypeptide binding]; other site 507522001712 active site 507522001713 nudix motif; other site 507522001714 metal binding site [ion binding]; metal-binding site 507522001715 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 507522001716 Transglycosylase; Region: Transgly; pfam00912 507522001717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 507522001718 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 507522001719 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 507522001720 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 507522001721 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 507522001722 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 507522001723 shikimate kinase; Reviewed; Region: aroK; PRK00131 507522001724 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 507522001725 ADP binding site [chemical binding]; other site 507522001726 magnesium binding site [ion binding]; other site 507522001727 putative shikimate binding site; other site 507522001728 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 507522001729 active site 507522001730 dimer interface [polypeptide binding]; other site 507522001731 metal binding site [ion binding]; metal-binding site 507522001732 cell division protein DamX; Validated; Region: PRK10905 507522001733 hypothetical protein; Reviewed; Region: PRK11901 507522001734 DNA adenine methylase; Provisional; Region: PRK10904 507522001735 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 507522001736 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 507522001737 substrate binding site [chemical binding]; other site 507522001738 hexamer interface [polypeptide binding]; other site 507522001739 metal binding site [ion binding]; metal-binding site 507522001740 phosphoglycolate phosphatase; Provisional; Region: PRK13222 507522001741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522001742 motif II; other site 507522001743 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 507522001744 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 507522001745 active site 507522001746 HIGH motif; other site 507522001747 dimer interface [polypeptide binding]; other site 507522001748 KMSKS motif; other site 507522001749 siroheme synthase; Provisional; Region: cysG; PRK10637 507522001750 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 507522001751 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 507522001752 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 507522001753 active site 507522001754 SAM binding site [chemical binding]; other site 507522001755 homodimer interface [polypeptide binding]; other site 507522001756 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 507522001757 nitrite reductase subunit NirD; Provisional; Region: PRK14989 507522001758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522001759 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 507522001760 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522001761 cytosine deaminase; Provisional; Region: PRK09230 507522001762 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 507522001763 active site 507522001764 putative transporter; Provisional; Region: PRK03699 507522001765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522001766 putative substrate translocation pore; other site 507522001767 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 507522001768 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 507522001769 substrate binding site [chemical binding]; other site 507522001770 hypothetical protein; Provisional; Region: PRK10204 507522001771 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 507522001772 cell filamentation protein Fic; Provisional; Region: PRK10347 507522001773 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 507522001774 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 507522001775 glutamine binding [chemical binding]; other site 507522001776 catalytic triad [active] 507522001777 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 507522001778 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522001779 inhibitor-cofactor binding pocket; inhibition site 507522001780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522001781 catalytic residue [active] 507522001782 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 507522001783 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 507522001784 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522001785 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 507522001786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 507522001787 ligand binding site [chemical binding]; other site 507522001788 flexible hinge region; other site 507522001789 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 507522001790 putative switch regulator; other site 507522001791 non-specific DNA interactions [nucleotide binding]; other site 507522001792 DNA binding site [nucleotide binding] 507522001793 sequence specific DNA binding site [nucleotide binding]; other site 507522001794 putative cAMP binding site [chemical binding]; other site 507522001795 hypothetical protein; Provisional; Region: PRK10738 507522001796 phosphoribulokinase; Provisional; Region: PRK15453 507522001797 active site 507522001798 hypothetical protein; Provisional; Region: PRK04966 507522001799 putative hydrolase; Provisional; Region: PRK10985 507522001800 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 507522001801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522001802 Walker A/P-loop; other site 507522001803 ATP binding site [chemical binding]; other site 507522001804 Q-loop/lid; other site 507522001805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522001806 ABC transporter signature motif; other site 507522001807 Walker B; other site 507522001808 D-loop; other site 507522001809 ABC transporter; Region: ABC_tran_2; pfam12848 507522001810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522001811 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 507522001812 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 507522001813 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 507522001814 TrkA-N domain; Region: TrkA_N; pfam02254 507522001815 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 507522001816 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 507522001817 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522001818 phi X174 lysis protein; Provisional; Region: PRK02793 507522001819 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 507522001820 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 507522001821 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522001822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 507522001823 YheO-like PAS domain; Region: PAS_6; pfam08348 507522001824 HTH domain; Region: HTH_22; pfam13309 507522001825 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 507522001826 sulfur relay protein TusC; Validated; Region: PRK00211 507522001827 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 507522001828 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 507522001829 S17 interaction site [polypeptide binding]; other site 507522001830 S8 interaction site; other site 507522001831 16S rRNA interaction site [nucleotide binding]; other site 507522001832 streptomycin interaction site [chemical binding]; other site 507522001833 23S rRNA interaction site [nucleotide binding]; other site 507522001834 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 507522001835 30S ribosomal protein S7; Validated; Region: PRK05302 507522001836 elongation factor G; Reviewed; Region: PRK00007 507522001837 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 507522001838 G1 box; other site 507522001839 putative GEF interaction site [polypeptide binding]; other site 507522001840 GTP/Mg2+ binding site [chemical binding]; other site 507522001841 Switch I region; other site 507522001842 G2 box; other site 507522001843 G3 box; other site 507522001844 Switch II region; other site 507522001845 G4 box; other site 507522001846 G5 box; other site 507522001847 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 507522001848 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 507522001849 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 507522001850 elongation factor Tu; Reviewed; Region: PRK00049 507522001851 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 507522001852 G1 box; other site 507522001853 GEF interaction site [polypeptide binding]; other site 507522001854 GTP/Mg2+ binding site [chemical binding]; other site 507522001855 Switch I region; other site 507522001856 G2 box; other site 507522001857 G3 box; other site 507522001858 Switch II region; other site 507522001859 G4 box; other site 507522001860 G5 box; other site 507522001861 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 507522001862 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 507522001863 Antibiotic Binding Site [chemical binding]; other site 507522001864 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 507522001865 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 507522001866 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 507522001867 heme binding site [chemical binding]; other site 507522001868 ferroxidase pore; other site 507522001869 ferroxidase diiron center [ion binding]; other site 507522001870 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 507522001871 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 507522001872 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 507522001873 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 507522001874 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 507522001875 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 507522001876 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 507522001877 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 507522001878 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 507522001879 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 507522001880 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 507522001881 protein-rRNA interface [nucleotide binding]; other site 507522001882 putative translocon binding site; other site 507522001883 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 507522001884 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 507522001885 G-X-X-G motif; other site 507522001886 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 507522001887 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 507522001888 23S rRNA interface [nucleotide binding]; other site 507522001889 5S rRNA interface [nucleotide binding]; other site 507522001890 putative antibiotic binding site [chemical binding]; other site 507522001891 L25 interface [polypeptide binding]; other site 507522001892 L27 interface [polypeptide binding]; other site 507522001893 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 507522001894 23S rRNA interface [nucleotide binding]; other site 507522001895 putative translocon interaction site; other site 507522001896 signal recognition particle (SRP54) interaction site; other site 507522001897 L23 interface [polypeptide binding]; other site 507522001898 trigger factor interaction site; other site 507522001899 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 507522001900 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 507522001901 RNA binding site [nucleotide binding]; other site 507522001902 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 507522001903 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 507522001904 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 507522001905 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 507522001906 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 507522001907 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 507522001908 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 507522001909 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 507522001910 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 507522001911 23S rRNA interface [nucleotide binding]; other site 507522001912 5S rRNA interface [nucleotide binding]; other site 507522001913 L27 interface [polypeptide binding]; other site 507522001914 L5 interface [polypeptide binding]; other site 507522001915 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 507522001916 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 507522001917 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 507522001918 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 507522001919 23S rRNA binding site [nucleotide binding]; other site 507522001920 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 507522001921 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 507522001922 SecY translocase; Region: SecY; pfam00344 507522001923 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 507522001924 30S ribosomal protein S13; Region: bact_S13; TIGR03631 507522001925 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 507522001926 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 507522001927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522001928 RNA binding surface [nucleotide binding]; other site 507522001929 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 507522001930 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 507522001931 alphaNTD homodimer interface [polypeptide binding]; other site 507522001932 alphaNTD - beta interaction site [polypeptide binding]; other site 507522001933 alphaNTD - beta' interaction site [polypeptide binding]; other site 507522001934 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 507522001935 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 507522001936 hypothetical protein; Provisional; Region: PRK10203 507522001937 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 507522001938 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 507522001939 DNA binding residues [nucleotide binding] 507522001940 dimer interface [polypeptide binding]; other site 507522001941 metal binding site [ion binding]; metal-binding site 507522001942 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 507522001943 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 507522001944 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 507522001945 TrkA-N domain; Region: TrkA_N; pfam02254 507522001946 TrkA-C domain; Region: TrkA_C; pfam02080 507522001947 TrkA-N domain; Region: TrkA_N; pfam02254 507522001948 TrkA-C domain; Region: TrkA_C; pfam02080 507522001949 16S rRNA methyltransferase B; Provisional; Region: PRK10901 507522001950 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 507522001951 putative RNA binding site [nucleotide binding]; other site 507522001952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522001953 S-adenosylmethionine binding site [chemical binding]; other site 507522001954 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 507522001955 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 507522001956 putative active site [active] 507522001957 substrate binding site [chemical binding]; other site 507522001958 putative cosubstrate binding site; other site 507522001959 catalytic site [active] 507522001960 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 507522001961 substrate binding site [chemical binding]; other site 507522001962 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 507522001963 active site 507522001964 catalytic residues [active] 507522001965 metal binding site [ion binding]; metal-binding site 507522001966 hypothetical protein; Provisional; Region: PRK10736 507522001967 DNA protecting protein DprA; Region: dprA; TIGR00732 507522001968 hypothetical protein; Validated; Region: PRK03430 507522001969 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 507522001970 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 507522001971 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 507522001972 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 507522001973 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 507522001974 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 507522001975 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 507522001976 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 507522001977 shikimate binding site; other site 507522001978 NAD(P) binding site [chemical binding]; other site 507522001979 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 507522001980 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 507522001981 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 507522001982 trimer interface [polypeptide binding]; other site 507522001983 putative metal binding site [ion binding]; other site 507522001984 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 507522001985 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 507522001986 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 507522001987 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 507522001988 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522001989 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522001990 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 507522001991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522001992 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 507522001993 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 507522001994 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 507522001995 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 507522001996 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 507522001997 FMN binding site [chemical binding]; other site 507522001998 active site 507522001999 catalytic residues [active] 507522002000 substrate binding site [chemical binding]; other site 507522002001 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 507522002002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 507522002003 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 507522002004 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 507522002005 Na binding site [ion binding]; other site 507522002006 hypothetical protein; Provisional; Region: PRK10633 507522002007 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 507522002008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 507522002009 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 507522002010 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 507522002011 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 507522002012 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 507522002013 carboxyltransferase (CT) interaction site; other site 507522002014 biotinylation site [posttranslational modification]; other site 507522002015 Dehydroquinase class II; Region: DHquinase_II; pfam01220 507522002016 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 507522002017 trimer interface [polypeptide binding]; other site 507522002018 active site 507522002019 dimer interface [polypeptide binding]; other site 507522002020 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 507522002021 TMAO/DMSO reductase; Reviewed; Region: PRK05363 507522002022 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 507522002023 Moco binding site; other site 507522002024 metal coordination site [ion binding]; other site 507522002025 sensor protein PhoQ; Provisional; Region: PRK10815 507522002026 regulatory protein CsrD; Provisional; Region: PRK11059 507522002027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522002028 metal binding site [ion binding]; metal-binding site 507522002029 active site 507522002030 I-site; other site 507522002031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522002032 rod shape-determining protein MreB; Provisional; Region: PRK13927 507522002033 MreB and similar proteins; Region: MreB_like; cd10225 507522002034 nucleotide binding site [chemical binding]; other site 507522002035 Mg binding site [ion binding]; other site 507522002036 putative protofilament interaction site [polypeptide binding]; other site 507522002037 RodZ interaction site [polypeptide binding]; other site 507522002038 rod shape-determining protein MreC; Region: mreC; TIGR00219 507522002039 rod shape-determining protein MreC; Region: MreC; pfam04085 507522002040 rod shape-determining protein MreD; Provisional; Region: PRK11060 507522002041 Maf-like protein; Region: Maf; pfam02545 507522002042 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 507522002043 active site 507522002044 dimer interface [polypeptide binding]; other site 507522002045 ribonuclease G; Provisional; Region: PRK11712 507522002046 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 507522002047 homodimer interface [polypeptide binding]; other site 507522002048 oligonucleotide binding site [chemical binding]; other site 507522002049 hypothetical protein; Provisional; Region: PRK10899 507522002050 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 507522002051 protease TldD; Provisional; Region: tldD; PRK10735 507522002052 transcriptional regulator; Provisional; Region: PRK10632 507522002053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522002054 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522002055 putative effector binding pocket; other site 507522002056 dimerization interface [polypeptide binding]; other site 507522002057 efflux system membrane protein; Provisional; Region: PRK11594 507522002058 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 507522002059 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522002060 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522002061 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 507522002062 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522002063 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 507522002064 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 507522002065 RNAase interaction site [polypeptide binding]; other site 507522002066 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 507522002067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522002068 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522002069 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522002070 arginine repressor; Provisional; Region: PRK05066 507522002071 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 507522002072 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 507522002073 malate dehydrogenase; Provisional; Region: PRK05086 507522002074 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 507522002075 NAD binding site [chemical binding]; other site 507522002076 dimerization interface [polypeptide binding]; other site 507522002077 Substrate binding site [chemical binding]; other site 507522002078 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522002079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522002080 DNA-binding site [nucleotide binding]; DNA binding site 507522002081 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522002082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522002083 DNA-binding site [nucleotide binding]; DNA binding site 507522002084 FCD domain; Region: FCD; pfam07729 507522002085 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522002086 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 507522002087 transmembrane helices; other site 507522002088 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 507522002089 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 507522002090 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 507522002091 oxaloacetate decarboxylase; Provisional; Region: PRK14040 507522002092 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 507522002093 active site 507522002094 catalytic residues [active] 507522002095 metal binding site [ion binding]; metal-binding site 507522002096 homodimer binding site [polypeptide binding]; other site 507522002097 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 507522002098 carboxyltransferase (CT) interaction site; other site 507522002099 biotinylation site [posttranslational modification]; other site 507522002100 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 507522002101 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 507522002102 serine endoprotease; Provisional; Region: PRK10898 507522002103 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 507522002104 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 507522002105 protein binding site [polypeptide binding]; other site 507522002106 serine endoprotease; Provisional; Region: PRK10139 507522002107 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 507522002108 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 507522002109 protein binding site [polypeptide binding]; other site 507522002110 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 507522002111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 507522002112 hypothetical protein; Provisional; Region: PRK11677 507522002113 Predicted ATPase [General function prediction only]; Region: COG1485 507522002114 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 507522002115 23S rRNA interface [nucleotide binding]; other site 507522002116 L3 interface [polypeptide binding]; other site 507522002117 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 507522002118 stringent starvation protein A; Provisional; Region: sspA; PRK09481 507522002119 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 507522002120 C-terminal domain interface [polypeptide binding]; other site 507522002121 putative GSH binding site (G-site) [chemical binding]; other site 507522002122 dimer interface [polypeptide binding]; other site 507522002123 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 507522002124 dimer interface [polypeptide binding]; other site 507522002125 N-terminal domain interface [polypeptide binding]; other site 507522002126 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 507522002127 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 507522002128 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 507522002129 putative active site cavity [active] 507522002130 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 507522002131 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 507522002132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522002133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522002134 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 507522002135 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 507522002136 active site 507522002137 dimer interface [polypeptide binding]; other site 507522002138 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 507522002139 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 507522002140 active site 507522002141 FMN binding site [chemical binding]; other site 507522002142 substrate binding site [chemical binding]; other site 507522002143 3Fe-4S cluster binding site [ion binding]; other site 507522002144 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 507522002145 domain interface; other site 507522002146 radical SAM protein, TIGR01212 family; Region: TIGR01212 507522002147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522002148 FeS/SAM binding site; other site 507522002149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522002150 D-galactonate transporter; Region: 2A0114; TIGR00893 507522002151 putative substrate translocation pore; other site 507522002152 putative oxidoreductase; Provisional; Region: PRK10083 507522002153 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 507522002154 putative NAD(P) binding site [chemical binding]; other site 507522002155 catalytic Zn binding site [ion binding]; other site 507522002156 structural Zn binding site [ion binding]; other site 507522002157 mannonate dehydratase; Provisional; Region: PRK03906 507522002158 mannonate dehydratase; Region: uxuA; TIGR00695 507522002159 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 507522002160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522002161 putative active site [active] 507522002162 heme pocket [chemical binding]; other site 507522002163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522002164 dimer interface [polypeptide binding]; other site 507522002165 phosphorylation site [posttranslational modification] 507522002166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522002167 ATP binding site [chemical binding]; other site 507522002168 Mg2+ binding site [ion binding]; other site 507522002169 G-X-G motif; other site 507522002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522002171 active site 507522002172 phosphorylation site [posttranslational modification] 507522002173 intermolecular recognition site; other site 507522002174 dimerization interface [polypeptide binding]; other site 507522002175 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 507522002176 putative binding surface; other site 507522002177 active site 507522002178 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 507522002179 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 507522002180 conserved cys residue [active] 507522002181 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 507522002182 Transglycosylase; Region: Transgly; cl17702 507522002183 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 507522002184 dimerization domain swap beta strand [polypeptide binding]; other site 507522002185 regulatory protein interface [polypeptide binding]; other site 507522002186 active site 507522002187 regulatory phosphorylation site [posttranslational modification]; other site 507522002188 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 507522002189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522002190 active site 507522002191 phosphorylation site [posttranslational modification] 507522002192 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 507522002193 30S subunit binding site; other site 507522002194 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 507522002195 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 507522002196 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 507522002197 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 507522002198 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 507522002199 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 507522002200 Walker A/P-loop; other site 507522002201 ATP binding site [chemical binding]; other site 507522002202 Q-loop/lid; other site 507522002203 ABC transporter signature motif; other site 507522002204 Walker B; other site 507522002205 D-loop; other site 507522002206 H-loop/switch region; other site 507522002207 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 507522002208 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 507522002209 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 507522002210 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 507522002211 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 507522002212 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 507522002213 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 507522002214 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 507522002215 putative active site [active] 507522002216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 507522002217 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 507522002218 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 507522002219 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 507522002220 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 507522002221 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 507522002222 Walker A/P-loop; other site 507522002223 ATP binding site [chemical binding]; other site 507522002224 Q-loop/lid; other site 507522002225 ABC transporter signature motif; other site 507522002226 Walker B; other site 507522002227 D-loop; other site 507522002228 H-loop/switch region; other site 507522002229 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 507522002230 conserved hypothetical integral membrane protein; Region: TIGR00056 507522002231 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 507522002232 mce related protein; Region: MCE; pfam02470 507522002233 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 507522002234 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 507522002235 anti sigma factor interaction site; other site 507522002236 regulatory phosphorylation site [posttranslational modification]; other site 507522002237 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 507522002238 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 507522002239 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 507522002240 hinge; other site 507522002241 active site 507522002242 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 507522002243 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 507522002244 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 507522002245 substrate binding pocket [chemical binding]; other site 507522002246 chain length determination region; other site 507522002247 substrate-Mg2+ binding site; other site 507522002248 catalytic residues [active] 507522002249 aspartate-rich region 1; other site 507522002250 active site lid residues [active] 507522002251 aspartate-rich region 2; other site 507522002252 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 507522002253 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 507522002254 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 507522002255 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 507522002256 EamA-like transporter family; Region: EamA; pfam00892 507522002257 GTPase CgtA; Reviewed; Region: obgE; PRK12298 507522002258 GTP1/OBG; Region: GTP1_OBG; pfam01018 507522002259 Obg GTPase; Region: Obg; cd01898 507522002260 G1 box; other site 507522002261 GTP/Mg2+ binding site [chemical binding]; other site 507522002262 Switch I region; other site 507522002263 G2 box; other site 507522002264 G3 box; other site 507522002265 Switch II region; other site 507522002266 G4 box; other site 507522002267 G5 box; other site 507522002268 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 507522002269 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 507522002270 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 507522002271 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 507522002272 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 507522002273 RNA-binding protein YhbY; Provisional; Region: PRK10343 507522002274 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 507522002275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522002276 S-adenosylmethionine binding site [chemical binding]; other site 507522002277 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 507522002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522002279 Walker A motif; other site 507522002280 ATP binding site [chemical binding]; other site 507522002281 Walker B motif; other site 507522002282 arginine finger; other site 507522002283 Peptidase family M41; Region: Peptidase_M41; pfam01434 507522002284 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 507522002285 dihydropteroate synthase; Region: DHPS; TIGR01496 507522002286 substrate binding pocket [chemical binding]; other site 507522002287 dimer interface [polypeptide binding]; other site 507522002288 inhibitor binding site; inhibition site 507522002289 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 507522002290 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 507522002291 active site 507522002292 substrate binding site [chemical binding]; other site 507522002293 metal binding site [ion binding]; metal-binding site 507522002294 Preprotein translocase SecG subunit; Region: SecG; pfam03840 507522002295 YfaZ precursor; Region: YfaZ; pfam07437 507522002296 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 507522002297 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 507522002298 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 507522002299 argininosuccinate synthase; Validated; Region: PRK05370 507522002300 argininosuccinate synthase; Provisional; Region: PRK13820 507522002301 ribosome maturation protein RimP; Reviewed; Region: PRK00092 507522002302 Sm and related proteins; Region: Sm_like; cl00259 507522002303 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 507522002304 putative oligomer interface [polypeptide binding]; other site 507522002305 putative RNA binding site [nucleotide binding]; other site 507522002306 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 507522002307 NusA N-terminal domain; Region: NusA_N; pfam08529 507522002308 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 507522002309 RNA binding site [nucleotide binding]; other site 507522002310 homodimer interface [polypeptide binding]; other site 507522002311 NusA-like KH domain; Region: KH_5; pfam13184 507522002312 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 507522002313 G-X-X-G motif; other site 507522002314 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 507522002315 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 507522002316 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 507522002317 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 507522002318 translation initiation factor IF-2; Region: IF-2; TIGR00487 507522002319 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 507522002320 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 507522002321 G1 box; other site 507522002322 putative GEF interaction site [polypeptide binding]; other site 507522002323 GTP/Mg2+ binding site [chemical binding]; other site 507522002324 Switch I region; other site 507522002325 G2 box; other site 507522002326 G3 box; other site 507522002327 Switch II region; other site 507522002328 G4 box; other site 507522002329 G5 box; other site 507522002330 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 507522002331 Translation-initiation factor 2; Region: IF-2; pfam11987 507522002332 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 507522002333 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 507522002334 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 507522002335 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 507522002336 RNA binding site [nucleotide binding]; other site 507522002337 active site 507522002338 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 507522002339 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 507522002340 16S/18S rRNA binding site [nucleotide binding]; other site 507522002341 S13e-L30e interaction site [polypeptide binding]; other site 507522002342 25S rRNA binding site [nucleotide binding]; other site 507522002343 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 507522002344 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 507522002345 RNase E interface [polypeptide binding]; other site 507522002346 trimer interface [polypeptide binding]; other site 507522002347 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 507522002348 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 507522002349 RNase E interface [polypeptide binding]; other site 507522002350 trimer interface [polypeptide binding]; other site 507522002351 active site 507522002352 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 507522002353 putative nucleic acid binding region [nucleotide binding]; other site 507522002354 G-X-X-G motif; other site 507522002355 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 507522002356 RNA binding site [nucleotide binding]; other site 507522002357 domain interface; other site 507522002358 lipoprotein NlpI; Provisional; Region: PRK11189 507522002359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522002360 binding surface 507522002361 TPR motif; other site 507522002362 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 507522002363 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 507522002364 ATP binding site [chemical binding]; other site 507522002365 Mg++ binding site [ion binding]; other site 507522002366 motif III; other site 507522002367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522002368 nucleotide binding region [chemical binding]; other site 507522002369 ATP-binding site [chemical binding]; other site 507522002370 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 507522002371 putative RNA binding site [nucleotide binding]; other site 507522002372 tryptophan permease; Provisional; Region: PRK10483 507522002373 aromatic amino acid transport protein; Region: araaP; TIGR00837 507522002374 hypothetical protein; Provisional; Region: PRK10508 507522002375 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 507522002376 putative protease; Provisional; Region: PRK15447 507522002377 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 507522002378 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 507522002379 Peptidase family U32; Region: Peptidase_U32; pfam01136 507522002380 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 507522002381 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 507522002382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522002383 Coenzyme A binding pocket [chemical binding]; other site 507522002384 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 507522002385 GIY-YIG motif/motif A; other site 507522002386 putative active site [active] 507522002387 putative metal binding site [ion binding]; other site 507522002388 hypothetical protein; Provisional; Region: PRK03467 507522002389 intracellular protease, PfpI family; Region: PfpI; TIGR01382 507522002390 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 507522002391 proposed catalytic triad [active] 507522002392 conserved cys residue [active] 507522002393 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 507522002394 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 507522002395 NAD binding site [chemical binding]; other site 507522002396 active site 507522002397 Predicted permease; Region: DUF318; pfam03773 507522002398 outer membrane lipoprotein; Provisional; Region: PRK11023 507522002399 BON domain; Region: BON; pfam04972 507522002400 BON domain; Region: BON; pfam04972 507522002401 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 507522002402 dimer interface [polypeptide binding]; other site 507522002403 active site 507522002404 hypothetical protein; Reviewed; Region: PRK12497 507522002405 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 507522002406 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 507522002407 putative ligand binding site [chemical binding]; other site 507522002408 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 507522002409 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 507522002410 putative SAM binding site [chemical binding]; other site 507522002411 putative homodimer interface [polypeptide binding]; other site 507522002412 galactarate dehydratase; Region: galactar-dH20; TIGR03248 507522002413 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 507522002414 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 507522002415 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 507522002416 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 507522002417 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 507522002418 glycerate kinase I; Provisional; Region: PRK10342 507522002419 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 507522002420 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 507522002421 dimer interface [polypeptide binding]; other site 507522002422 Pirin-related protein [General function prediction only]; Region: COG1741 507522002423 Pirin; Region: Pirin; pfam02678 507522002424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522002425 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 507522002426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522002427 dimerization interface [polypeptide binding]; other site 507522002428 Predicted membrane protein [Function unknown]; Region: COG3152 507522002429 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 507522002430 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 507522002431 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 507522002432 putative dimer interface [polypeptide binding]; other site 507522002433 N-terminal domain interface [polypeptide binding]; other site 507522002434 putative substrate binding pocket (H-site) [chemical binding]; other site 507522002435 Predicted membrane protein [Function unknown]; Region: COG2259 507522002436 YqjK-like protein; Region: YqjK; pfam13997 507522002437 Predicted membrane protein [Function unknown]; Region: COG5393 507522002438 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 507522002439 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 507522002440 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 507522002441 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522002442 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 507522002443 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 507522002444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522002445 DNA-binding site [nucleotide binding]; DNA binding site 507522002446 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522002447 D-galactonate transporter; Region: 2A0114; TIGR00893 507522002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522002449 putative substrate translocation pore; other site 507522002450 Glucuronate isomerase; Region: UxaC; pfam02614 507522002451 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 507522002452 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 507522002453 galactarate dehydratase; Region: galactar-dH20; TIGR03248 507522002454 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 507522002455 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 507522002456 serine/threonine transporter SstT; Provisional; Region: PRK13628 507522002457 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 507522002458 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 507522002459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522002460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522002461 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 507522002462 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 507522002463 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 507522002464 inhibitor binding site; inhibition site 507522002465 active site 507522002466 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522002467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522002468 putative symporter YagG; Provisional; Region: PRK09669 507522002469 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 507522002470 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 507522002471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522002472 S-adenosylmethionine binding site [chemical binding]; other site 507522002473 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522002474 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 507522002475 active site 507522002476 FMN binding site [chemical binding]; other site 507522002477 2,4-decadienoyl-CoA binding site; other site 507522002478 catalytic residue [active] 507522002479 4Fe-4S cluster binding site [ion binding]; other site 507522002480 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 507522002481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522002482 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 507522002483 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 507522002484 putative N- and C-terminal domain interface [polypeptide binding]; other site 507522002485 putative active site [active] 507522002486 putative MgATP binding site [chemical binding]; other site 507522002487 catalytic site [active] 507522002488 metal binding site [ion binding]; metal-binding site 507522002489 putative carbohydrate binding site [chemical binding]; other site 507522002490 transcriptional regulator LsrR; Provisional; Region: PRK15418 507522002491 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 507522002492 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 507522002493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522002494 Walker A/P-loop; other site 507522002495 ATP binding site [chemical binding]; other site 507522002496 Q-loop/lid; other site 507522002497 ABC transporter signature motif; other site 507522002498 Walker B; other site 507522002499 D-loop; other site 507522002500 H-loop/switch region; other site 507522002501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522002502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522002503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522002504 TM-ABC transporter signature motif; other site 507522002505 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522002506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522002507 TM-ABC transporter signature motif; other site 507522002508 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 507522002509 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 507522002510 ligand binding site [chemical binding]; other site 507522002511 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 507522002512 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 507522002513 putative active site; other site 507522002514 catalytic residue [active] 507522002515 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 507522002516 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 507522002517 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522002518 inhibitor-cofactor binding pocket; inhibition site 507522002519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002520 catalytic residue [active] 507522002521 Predicted transcriptional regulators [Transcription]; Region: COG1695 507522002522 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 507522002523 GLE1-like protein; Region: GLE1; pfam07817 507522002524 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 507522002525 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 507522002526 FAD binding pocket [chemical binding]; other site 507522002527 FAD binding motif [chemical binding]; other site 507522002528 phosphate binding motif [ion binding]; other site 507522002529 NAD binding pocket [chemical binding]; other site 507522002530 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 507522002531 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 507522002532 DAK2 domain; Region: Dak2; pfam02734 507522002533 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 507522002534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 507522002535 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 507522002536 dimerization domain swap beta strand [polypeptide binding]; other site 507522002537 regulatory protein interface [polypeptide binding]; other site 507522002538 active site 507522002539 regulatory phosphorylation site [posttranslational modification]; other site 507522002540 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 507522002541 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 507522002542 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 507522002543 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 507522002544 Dak1 domain; Region: Dak1; pfam02733 507522002545 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 507522002546 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 507522002547 dimer interface [polypeptide binding]; other site 507522002548 active site 507522002549 metal binding site [ion binding]; metal-binding site 507522002550 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 507522002551 PAS domain; Region: PAS; smart00091 507522002552 putative active site [active] 507522002553 heme pocket [chemical binding]; other site 507522002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522002555 Walker A motif; other site 507522002556 ATP binding site [chemical binding]; other site 507522002557 Walker B motif; other site 507522002558 arginine finger; other site 507522002559 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522002560 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 507522002561 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 507522002562 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 507522002563 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 507522002564 dimer interface [polypeptide binding]; other site 507522002565 active site 507522002566 metal binding site [ion binding]; metal-binding site 507522002567 Domain of unknown function (DUF336); Region: DUF336; pfam03928 507522002568 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 507522002569 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 507522002570 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 507522002571 alpha-beta subunit interface [polypeptide binding]; other site 507522002572 alpha-gamma subunit interface [polypeptide binding]; other site 507522002573 active site 507522002574 substrate and K+ binding site; other site 507522002575 K+ binding site [ion binding]; other site 507522002576 cobalamin binding site [chemical binding]; other site 507522002577 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 507522002578 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 507522002579 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 507522002580 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 507522002581 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 507522002582 amphipathic channel; other site 507522002583 Asn-Pro-Ala signature motifs; other site 507522002584 acid-resistance protein; Provisional; Region: hdeB; PRK11566 507522002585 acid-resistance membrane protein; Provisional; Region: PRK10209 507522002586 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 507522002587 hypothetical protein; Provisional; Region: PRK10316 507522002588 YfdX protein; Region: YfdX; pfam10938 507522002589 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 507522002590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522002591 substrate binding pocket [chemical binding]; other site 507522002592 membrane-bound complex binding site; other site 507522002593 hinge residues; other site 507522002594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522002595 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522002596 substrate binding pocket [chemical binding]; other site 507522002597 membrane-bound complex binding site; other site 507522002598 hinge residues; other site 507522002599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 507522002600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522002601 dimer interface [polypeptide binding]; other site 507522002602 phosphorylation site [posttranslational modification] 507522002603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522002604 ATP binding site [chemical binding]; other site 507522002605 Mg2+ binding site [ion binding]; other site 507522002606 G-X-G motif; other site 507522002607 Response regulator receiver domain; Region: Response_reg; pfam00072 507522002608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522002609 active site 507522002610 phosphorylation site [posttranslational modification] 507522002611 intermolecular recognition site; other site 507522002612 dimerization interface [polypeptide binding]; other site 507522002613 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 507522002614 putative binding surface; other site 507522002615 active site 507522002616 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 507522002617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522002618 active site 507522002619 phosphorylation site [posttranslational modification] 507522002620 intermolecular recognition site; other site 507522002621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522002622 DNA binding residues [nucleotide binding] 507522002623 dimerization interface [polypeptide binding]; other site 507522002624 HdeA/HdeB family; Region: HdeA; pfam06411 507522002625 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 507522002626 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522002627 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 507522002628 active site 507522002629 SUMO-1 interface [polypeptide binding]; other site 507522002630 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 507522002631 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 507522002632 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 507522002633 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 507522002634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 507522002635 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 507522002636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 507522002637 DNA binding residues [nucleotide binding] 507522002638 DNA primase; Validated; Region: dnaG; PRK05667 507522002639 CHC2 zinc finger; Region: zf-CHC2; pfam01807 507522002640 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 507522002641 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 507522002642 active site 507522002643 metal binding site [ion binding]; metal-binding site 507522002644 interdomain interaction site; other site 507522002645 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 507522002646 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 507522002647 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 507522002648 UGMP family protein; Validated; Region: PRK09604 507522002649 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 507522002650 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 507522002651 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 507522002652 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522002653 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 507522002654 UreF; Region: UreF; pfam01730 507522002655 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 507522002656 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 507522002657 dimer interface [polypeptide binding]; other site 507522002658 catalytic residues [active] 507522002659 urease subunit alpha; Reviewed; Region: ureC; PRK13207 507522002660 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 507522002661 subunit interactions [polypeptide binding]; other site 507522002662 active site 507522002663 flap region; other site 507522002664 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 507522002665 gamma-beta subunit interface [polypeptide binding]; other site 507522002666 alpha-beta subunit interface [polypeptide binding]; other site 507522002667 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 507522002668 alpha-gamma subunit interface [polypeptide binding]; other site 507522002669 beta-gamma subunit interface [polypeptide binding]; other site 507522002670 UreD urease accessory protein; Region: UreD; cl00530 507522002671 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 507522002672 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 507522002673 homooctamer interface [polypeptide binding]; other site 507522002674 active site 507522002675 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 507522002676 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 507522002677 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 507522002678 active site 507522002679 NTP binding site [chemical binding]; other site 507522002680 metal binding triad [ion binding]; metal-binding site 507522002681 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 507522002682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522002683 Zn2+ binding site [ion binding]; other site 507522002684 Mg2+ binding site [ion binding]; other site 507522002685 SH3 domain-containing protein; Provisional; Region: PRK10884 507522002686 Bacterial SH3 domain homologues; Region: SH3b; smart00287 507522002687 Uncharacterized conserved protein [Function unknown]; Region: COG3025 507522002688 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 507522002689 putative active site [active] 507522002690 putative metal binding residues [ion binding]; other site 507522002691 signature motif; other site 507522002692 putative triphosphate binding site [ion binding]; other site 507522002693 CHAD domain; Region: CHAD; pfam05235 507522002694 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 507522002695 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 507522002696 metal binding triad; other site 507522002697 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 507522002698 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 507522002699 metal binding triad; other site 507522002700 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 507522002701 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 507522002702 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 507522002703 putative ribose interaction site [chemical binding]; other site 507522002704 putative ADP binding site [chemical binding]; other site 507522002705 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 507522002706 active site 507522002707 nucleotide binding site [chemical binding]; other site 507522002708 HIGH motif; other site 507522002709 KMSKS motif; other site 507522002710 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 507522002711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 507522002712 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 507522002713 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 507522002714 zinc transporter ZupT; Provisional; Region: PRK04201 507522002715 ZIP Zinc transporter; Region: Zip; pfam02535 507522002716 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 507522002717 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 507522002718 putative active site [active] 507522002719 metal binding site [ion binding]; metal-binding site 507522002720 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 507522002721 hypothetical protein; Provisional; Region: PRK11653 507522002722 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 507522002723 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 507522002724 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 507522002725 dimer interface [polypeptide binding]; other site 507522002726 ADP-ribose binding site [chemical binding]; other site 507522002727 active site 507522002728 nudix motif; other site 507522002729 metal binding site [ion binding]; metal-binding site 507522002730 putative dehydrogenase; Provisional; Region: PRK11039 507522002731 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 507522002732 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522002733 active site 507522002734 metal binding site [ion binding]; metal-binding site 507522002735 hexamer interface [polypeptide binding]; other site 507522002736 esterase YqiA; Provisional; Region: PRK11071 507522002737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 507522002738 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 507522002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522002740 ATP binding site [chemical binding]; other site 507522002741 Mg2+ binding site [ion binding]; other site 507522002742 G-X-G motif; other site 507522002743 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 507522002744 anchoring element; other site 507522002745 dimer interface [polypeptide binding]; other site 507522002746 ATP binding site [chemical binding]; other site 507522002747 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 507522002748 active site 507522002749 metal binding site [ion binding]; metal-binding site 507522002750 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 507522002751 Uncharacterized conserved protein [Function unknown]; Region: COG1359 507522002752 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 507522002753 sensor protein QseC; Provisional; Region: PRK10337 507522002754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522002755 dimer interface [polypeptide binding]; other site 507522002756 phosphorylation site [posttranslational modification] 507522002757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522002758 ATP binding site [chemical binding]; other site 507522002759 Mg2+ binding site [ion binding]; other site 507522002760 G-X-G motif; other site 507522002761 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 507522002762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522002763 active site 507522002764 phosphorylation site [posttranslational modification] 507522002765 intermolecular recognition site; other site 507522002766 dimerization interface [polypeptide binding]; other site 507522002767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522002768 DNA binding site [nucleotide binding] 507522002769 TIGR00156 family protein; Region: TIGR00156 507522002770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522002771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522002772 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 507522002773 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 507522002774 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 507522002775 CAP-like domain; other site 507522002776 active site 507522002777 primary dimer interface [polypeptide binding]; other site 507522002778 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 507522002779 putative acyl-acceptor binding pocket; other site 507522002780 FtsI repressor; Provisional; Region: PRK10883 507522002781 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 507522002782 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 507522002783 hypothetical protein; Provisional; Region: PRK01254 507522002784 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 507522002785 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 507522002786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522002787 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522002788 active site 507522002789 catalytic tetrad [active] 507522002790 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 507522002791 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 507522002792 dimer interface [polypeptide binding]; other site 507522002793 active site 507522002794 metal binding site [ion binding]; metal-binding site 507522002795 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 507522002796 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522002797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522002798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522002799 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522002800 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522002801 cystathionine beta-lyase; Provisional; Region: PRK08114 507522002802 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 507522002803 homodimer interface [polypeptide binding]; other site 507522002804 substrate-cofactor binding pocket; other site 507522002805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002806 catalytic residue [active] 507522002807 biopolymer transport protein ExbB; Provisional; Region: PRK10414 507522002808 biopolymer transport protein ExbD; Provisional; Region: PRK11267 507522002809 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 507522002810 hypothetical protein; Provisional; Region: PRK05208 507522002811 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 507522002812 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522002813 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 507522002814 putative S-transferase; Provisional; Region: PRK11752 507522002815 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 507522002816 C-terminal domain interface [polypeptide binding]; other site 507522002817 GSH binding site (G-site) [chemical binding]; other site 507522002818 dimer interface [polypeptide binding]; other site 507522002819 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 507522002820 dimer interface [polypeptide binding]; other site 507522002821 N-terminal domain interface [polypeptide binding]; other site 507522002822 active site 507522002823 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 507522002824 Thioredoxin; Region: Thioredoxin_4; cl17273 507522002825 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 507522002826 CHAP domain; Region: CHAP; pfam05257 507522002827 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 507522002828 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 507522002829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522002830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002831 homodimer interface [polypeptide binding]; other site 507522002832 catalytic residue [active] 507522002833 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 507522002834 putative NAD(P) binding site [chemical binding]; other site 507522002835 homodimer interface [polypeptide binding]; other site 507522002836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522002837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522002838 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 507522002839 putative effector binding pocket; other site 507522002840 putative dimerization interface [polypeptide binding]; other site 507522002841 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 507522002842 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 507522002843 homodimer interface [polypeptide binding]; other site 507522002844 substrate-cofactor binding pocket; other site 507522002845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002846 catalytic residue [active] 507522002847 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 507522002848 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 507522002849 dimer interface [polypeptide binding]; other site 507522002850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002851 catalytic residue [active] 507522002852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 507522002853 FOG: CBS domain [General function prediction only]; Region: COG0517 507522002854 Protein of unknown function (DUF554); Region: DUF554; pfam04474 507522002855 ornithine decarboxylase; Provisional; Region: PRK13578 507522002856 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 507522002857 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 507522002858 homodimer interface [polypeptide binding]; other site 507522002859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522002860 catalytic residue [active] 507522002861 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 507522002862 nucleoside transporter; Region: 2A0110; TIGR00889 507522002863 murein transglycosylase C; Provisional; Region: mltC; PRK11671 507522002864 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 507522002865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522002866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522002867 catalytic residue [active] 507522002868 oxidative damage protection protein; Provisional; Region: PRK05408 507522002869 adenine DNA glycosylase; Provisional; Region: PRK10880 507522002870 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 507522002871 minor groove reading motif; other site 507522002872 helix-hairpin-helix signature motif; other site 507522002873 substrate binding pocket [chemical binding]; other site 507522002874 active site 507522002875 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 507522002876 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 507522002877 DNA binding and oxoG recognition site [nucleotide binding] 507522002878 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 507522002879 hypothetical protein; Provisional; Region: PRK11702 507522002880 hypothetical protein; Provisional; Region: PRK10626 507522002881 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 507522002882 HemN family oxidoreductase; Provisional; Region: PRK05660 507522002883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522002884 FeS/SAM binding site; other site 507522002885 HemN C-terminal domain; Region: HemN_C; pfam06969 507522002886 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 507522002887 active site 507522002888 dimerization interface [polypeptide binding]; other site 507522002889 hypothetical protein; Validated; Region: PRK05090 507522002890 YGGT family; Region: YGGT; pfam02325 507522002891 YGGT family; Region: YGGT; pfam02325 507522002892 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 507522002893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 507522002894 catalytic residue [active] 507522002895 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 507522002896 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 507522002897 Walker A motif; other site 507522002898 ATP binding site [chemical binding]; other site 507522002899 Walker B motif; other site 507522002900 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 507522002901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522002902 DNA binding residues [nucleotide binding] 507522002903 dimerization interface [polypeptide binding]; other site 507522002904 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 507522002905 hypothetical protein; Validated; Region: PRK00228 507522002906 glutathione synthetase; Provisional; Region: PRK05246 507522002907 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 507522002908 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 507522002909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 507522002910 RNA methyltransferase, RsmE family; Region: TIGR00046 507522002911 DNA-specific endonuclease I; Provisional; Region: PRK15137 507522002912 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 507522002913 hypothetical protein; Provisional; Region: PRK04860 507522002914 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 507522002915 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 507522002916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522002917 putative substrate translocation pore; other site 507522002918 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 507522002919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522002920 S-adenosylmethionine synthetase; Validated; Region: PRK05250 507522002921 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 507522002922 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 507522002923 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 507522002924 Virulence promoting factor; Region: YqgB; pfam11036 507522002925 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 507522002926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 507522002927 dimer interface [polypeptide binding]; other site 507522002928 active site 507522002929 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 507522002930 catalytic residues [active] 507522002931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 507522002932 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 507522002933 agmatinase; Region: agmatinase; TIGR01230 507522002934 oligomer interface [polypeptide binding]; other site 507522002935 putative active site [active] 507522002936 Mn binding site [ion binding]; other site 507522002937 outer membrane porin, OprD family; Region: OprD; pfam03573 507522002938 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 507522002939 transketolase; Reviewed; Region: PRK12753 507522002940 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522002941 TPP-binding site [chemical binding]; other site 507522002942 dimer interface [polypeptide binding]; other site 507522002943 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522002944 PYR/PP interface [polypeptide binding]; other site 507522002945 dimer interface [polypeptide binding]; other site 507522002946 TPP binding site [chemical binding]; other site 507522002947 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522002948 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 507522002949 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 507522002950 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 507522002951 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 507522002952 Phosphoglycerate kinase; Region: PGK; pfam00162 507522002953 substrate binding site [chemical binding]; other site 507522002954 hinge regions; other site 507522002955 ADP binding site [chemical binding]; other site 507522002956 catalytic site [active] 507522002957 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 507522002958 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 507522002959 active site 507522002960 intersubunit interface [polypeptide binding]; other site 507522002961 zinc binding site [ion binding]; other site 507522002962 Na+ binding site [ion binding]; other site 507522002963 mechanosensitive channel MscS; Provisional; Region: PRK10334 507522002964 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522002965 arginine exporter protein; Provisional; Region: PRK09304 507522002966 Uncharacterized conserved protein [Function unknown]; Region: COG2968 507522002967 oxidative stress defense protein; Provisional; Region: PRK11087 507522002968 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 507522002969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522002970 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 507522002971 putative dimerization interface [polypeptide binding]; other site 507522002972 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 507522002973 tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522002974 active site 507522002975 dimer interface [polypeptide binding]; other site 507522002976 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 507522002977 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 507522002978 ligand binding site [chemical binding]; other site 507522002979 NAD binding site [chemical binding]; other site 507522002980 tetramer interface [polypeptide binding]; other site 507522002981 catalytic site [active] 507522002982 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 507522002983 L-serine binding site [chemical binding]; other site 507522002984 ACT domain interface; other site 507522002985 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 507522002986 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 507522002987 Z-ring-associated protein; Provisional; Region: PRK10972 507522002988 hypothetical protein; Reviewed; Region: PRK01736 507522002989 proline aminopeptidase P II; Provisional; Region: PRK10879 507522002990 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 507522002991 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 507522002992 active site 507522002993 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 507522002994 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 507522002995 oxidoreductase; Provisional; Region: PRK08013 507522002996 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 507522002997 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 507522002998 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 507522002999 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 507522003000 lipoyl attachment site [posttranslational modification]; other site 507522003001 glycine dehydrogenase; Provisional; Region: PRK05367 507522003002 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 507522003003 tetramer interface [polypeptide binding]; other site 507522003004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522003005 catalytic residue [active] 507522003006 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 507522003007 tetramer interface [polypeptide binding]; other site 507522003008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522003009 catalytic residue [active] 507522003010 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 507522003011 classical (c) SDRs; Region: SDR_c; cd05233 507522003012 NAD(P) binding site [chemical binding]; other site 507522003013 active site 507522003014 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 507522003015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 507522003016 catalytic residues [active] 507522003017 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 507522003018 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 507522003019 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 507522003020 catalytic residues [active] 507522003021 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 507522003022 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 507522003023 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 507522003024 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 507522003025 DsbD alpha interface [polypeptide binding]; other site 507522003026 catalytic residues [active] 507522003027 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 507522003028 beta-galactosidase; Region: BGL; TIGR03356 507522003029 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522003030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522003031 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522003032 putative active site [active] 507522003033 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 507522003034 hemolysin; Provisional; Region: PRK15087 507522003035 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 507522003036 putative global regulator; Reviewed; Region: PRK09559 507522003037 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 507522003038 hypothetical protein; Provisional; Region: PRK10878 507522003039 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 507522003040 flavodoxin FldB; Provisional; Region: PRK12359 507522003041 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 507522003042 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 507522003043 active site 507522003044 Int/Topo IB signature motif; other site 507522003045 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 507522003046 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 507522003047 dimerization domain [polypeptide binding]; other site 507522003048 dimer interface [polypeptide binding]; other site 507522003049 catalytic residues [active] 507522003050 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 507522003051 DHH family; Region: DHH; pfam01368 507522003052 DHHA1 domain; Region: DHHA1; pfam02272 507522003053 peptide chain release factor 2; Validated; Region: prfB; PRK00578 507522003054 This domain is found in peptide chain release factors; Region: PCRF; smart00937 507522003055 RF-1 domain; Region: RF-1; pfam00472 507522003056 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 507522003057 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 507522003058 dimer interface [polypeptide binding]; other site 507522003059 putative anticodon binding site; other site 507522003060 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 507522003061 motif 1; other site 507522003062 active site 507522003063 motif 2; other site 507522003064 motif 3; other site 507522003065 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 507522003066 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 507522003067 active site 507522003068 metal binding site [ion binding]; metal-binding site 507522003069 nudix motif; other site 507522003070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522003071 Peptidase family M23; Region: Peptidase_M23; pfam01551 507522003072 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 507522003073 Int/Topo IB signature motif; other site 507522003074 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 507522003075 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 507522003076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522003078 putative substrate translocation pore; other site 507522003079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522003080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003081 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 507522003082 putative substrate binding pocket [chemical binding]; other site 507522003083 putative dimerization interface [polypeptide binding]; other site 507522003084 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 507522003085 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 507522003086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522003087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522003088 active site 507522003089 catalytic tetrad [active] 507522003090 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 507522003091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522003092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522003094 dimerization interface [polypeptide binding]; other site 507522003095 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 507522003096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 507522003097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522003098 dimerization interface [polypeptide binding]; other site 507522003099 putative DNA binding site [nucleotide binding]; other site 507522003100 putative Zn2+ binding site [ion binding]; other site 507522003101 arsenical pump membrane protein; Provisional; Region: PRK15445 507522003102 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 507522003103 transmembrane helices; other site 507522003104 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 507522003105 ArsC family; Region: ArsC; pfam03960 507522003106 catalytic residues [active] 507522003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003108 putative substrate translocation pore; other site 507522003109 POT family; Region: PTR2; cl17359 507522003110 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 507522003111 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 507522003112 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 507522003113 multidrug resistance protein MdtN; Provisional; Region: PRK10476 507522003114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522003115 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522003116 Uncharacterized conserved protein [Function unknown]; Region: COG3592 507522003117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522003118 Coenzyme A binding pocket [chemical binding]; other site 507522003119 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522003120 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 507522003121 mannosyl binding site [chemical binding]; other site 507522003122 Fimbrial protein; Region: Fimbrial; cl01416 507522003123 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003124 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003125 outer membrane usher protein; Provisional; Region: PRK15193 507522003126 PapC N-terminal domain; Region: PapC_N; pfam13954 507522003127 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522003128 PapC C-terminal domain; Region: PapC_C; pfam13953 507522003129 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 507522003130 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522003131 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522003132 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003133 Fimbrial protein; Region: Fimbrial; cl01416 507522003134 tyrosine recombinase; Provisional; Region: PRK09871 507522003135 active site 507522003136 DNA binding site [nucleotide binding] 507522003137 Int/Topo IB signature motif; other site 507522003138 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 507522003139 Int/Topo IB signature motif; other site 507522003140 fimbrial chaperone protein; Provisional; Region: PRK15220 507522003141 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 507522003142 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522003143 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522003144 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 507522003145 PapC N-terminal domain; Region: PapC_N; pfam13954 507522003146 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522003147 PapC C-terminal domain; Region: PapC_C; pfam13953 507522003148 Fimbrial protein; Region: Fimbrial; pfam00419 507522003149 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 507522003150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522003151 MarR family; Region: MarR; pfam01047 507522003152 MarR family; Region: MarR_2; cl17246 507522003153 EamA-like transporter family; Region: EamA; pfam00892 507522003154 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522003155 EamA-like transporter family; Region: EamA; pfam00892 507522003156 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522003157 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003158 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522003159 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522003160 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522003161 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522003162 PapC N-terminal domain; Region: PapC_N; pfam13954 507522003163 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522003164 PapC C-terminal domain; Region: PapC_C; pfam13953 507522003165 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003166 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522003167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522003168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522003169 DNA binding residues [nucleotide binding] 507522003170 PilZ domain; Region: PilZ; pfam07238 507522003171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522003172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522003173 active site 507522003174 catalytic tetrad [active] 507522003175 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 507522003176 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 507522003177 Predicted membrane protein [Function unknown]; Region: COG4125 507522003178 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 507522003179 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 507522003180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522003181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522003183 dimerization interface [polypeptide binding]; other site 507522003184 putative acyltransferase; Provisional; Region: PRK05790 507522003185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522003186 dimer interface [polypeptide binding]; other site 507522003187 active site 507522003188 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 507522003189 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 507522003190 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 507522003191 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 507522003192 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 507522003193 NADP binding site [chemical binding]; other site 507522003194 homodimer interface [polypeptide binding]; other site 507522003195 active site 507522003196 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 507522003197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003198 putative substrate translocation pore; other site 507522003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522003201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522003202 DNA binding site [nucleotide binding] 507522003203 domain linker motif; other site 507522003204 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 507522003205 putative dimerization interface [polypeptide binding]; other site 507522003206 putative ligand binding site [chemical binding]; other site 507522003207 galactoside permease; Reviewed; Region: lacY; PRK09528 507522003208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003209 putative substrate translocation pore; other site 507522003210 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 507522003211 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 507522003212 substrate binding [chemical binding]; other site 507522003213 active site 507522003214 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 507522003215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 507522003216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 507522003217 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 507522003218 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 507522003219 Walker A/P-loop; other site 507522003220 ATP binding site [chemical binding]; other site 507522003221 Q-loop/lid; other site 507522003222 ABC transporter signature motif; other site 507522003223 Walker B; other site 507522003224 D-loop; other site 507522003225 H-loop/switch region; other site 507522003226 TOBE domain; Region: TOBE; pfam03459 507522003227 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522003228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522003229 dimer interface [polypeptide binding]; other site 507522003230 conserved gate region; other site 507522003231 putative PBP binding loops; other site 507522003232 ABC-ATPase subunit interface; other site 507522003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522003234 dimer interface [polypeptide binding]; other site 507522003235 conserved gate region; other site 507522003236 putative PBP binding loops; other site 507522003237 ABC-ATPase subunit interface; other site 507522003238 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 507522003239 putative racemase; Provisional; Region: PRK10200 507522003240 aspartate racemase; Region: asp_race; TIGR00035 507522003241 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 507522003242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522003244 dimerization interface [polypeptide binding]; other site 507522003245 diaminopimelate decarboxylase; Provisional; Region: PRK11165 507522003246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 507522003247 active site 507522003248 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 507522003249 substrate binding site [chemical binding]; other site 507522003250 catalytic residues [active] 507522003251 dimer interface [polypeptide binding]; other site 507522003252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522003253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522003254 DNA binding site [nucleotide binding] 507522003255 domain linker motif; other site 507522003256 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 507522003257 dimerization interface (closed form) [polypeptide binding]; other site 507522003258 ligand binding site [chemical binding]; other site 507522003259 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522003260 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522003261 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 507522003262 beta-galactosidase; Region: BGL; TIGR03356 507522003263 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 507522003264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522003265 DNA-binding site [nucleotide binding]; DNA binding site 507522003266 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522003267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522003268 Coenzyme A binding pocket [chemical binding]; other site 507522003269 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 507522003270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522003271 DNA binding site [nucleotide binding] 507522003272 domain linker motif; other site 507522003273 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 507522003274 dimerization interface (closed form) [polypeptide binding]; other site 507522003275 ligand binding site [chemical binding]; other site 507522003276 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 507522003277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 507522003278 putative acyl-acceptor binding pocket; other site 507522003279 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 507522003280 acyl-activating enzyme (AAE) consensus motif; other site 507522003281 putative AMP binding site [chemical binding]; other site 507522003282 lysophospholipid transporter LplT; Provisional; Region: PRK11195 507522003283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003284 putative substrate translocation pore; other site 507522003285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522003286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522003287 active site 507522003288 catalytic tetrad [active] 507522003289 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 507522003290 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 507522003291 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 507522003292 putative DNA-binding cleft [nucleotide binding]; other site 507522003293 putative DNA clevage site; other site 507522003294 molecular lever; other site 507522003295 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 507522003296 putative active site [active] 507522003297 Ap4A binding site [chemical binding]; other site 507522003298 nudix motif; other site 507522003299 putative metal binding site [ion binding]; other site 507522003300 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 507522003301 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 507522003302 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 507522003303 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 507522003304 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 507522003305 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 507522003306 thymidylate synthase; Reviewed; Region: thyA; PRK01827 507522003307 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 507522003308 dimerization interface [polypeptide binding]; other site 507522003309 active site 507522003310 hypothetical protein; Provisional; Region: PRK10506 507522003311 hypothetical protein; Provisional; Region: PRK10557 507522003312 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 507522003313 hypothetical protein; Provisional; Region: PRK11521 507522003314 hypothetical protein; Provisional; Region: PRK10332 507522003315 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 507522003316 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 507522003317 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 507522003318 protease3; Provisional; Region: PRK15101 507522003319 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 507522003320 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 507522003321 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 507522003322 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 507522003323 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 507522003324 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 507522003325 Family description; Region: UvrD_C_2; pfam13538 507522003326 N-acetylglutamate synthase; Validated; Region: PRK05279 507522003327 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 507522003328 putative feedback inhibition sensing region; other site 507522003329 putative nucleotide binding site [chemical binding]; other site 507522003330 putative substrate binding site [chemical binding]; other site 507522003331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522003332 Coenzyme A binding pocket [chemical binding]; other site 507522003333 AMIN domain; Region: AMIN; pfam11741 507522003334 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 507522003335 active site 507522003336 metal binding site [ion binding]; metal-binding site 507522003337 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 507522003338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522003339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522003340 homodimer interface [polypeptide binding]; other site 507522003341 catalytic residue [active] 507522003342 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 507522003343 propionate kinase; Reviewed; Region: PRK12397 507522003344 propionate/acetate kinase; Provisional; Region: PRK12379 507522003345 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 507522003346 G3 box; other site 507522003347 Switch II region; other site 507522003348 GTP/Mg2+ binding site [chemical binding]; other site 507522003349 G4 box; other site 507522003350 G5 box; other site 507522003351 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 507522003352 putative hexamer interface [polypeptide binding]; other site 507522003353 putative hexagonal pore; other site 507522003354 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 507522003355 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 507522003356 putative hexamer interface [polypeptide binding]; other site 507522003357 putative hexagonal pore; other site 507522003358 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 507522003359 catalytic site [active] 507522003360 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 507522003361 putative hexamer interface [polypeptide binding]; other site 507522003362 putative hexagonal pore; other site 507522003363 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 507522003364 SLBB domain; Region: SLBB; pfam10531 507522003365 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 507522003366 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 507522003367 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 507522003368 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 507522003369 active site 507522003370 NAD binding site [chemical binding]; other site 507522003371 metal binding site [ion binding]; metal-binding site 507522003372 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 507522003373 putative catalytic cysteine [active] 507522003374 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 507522003375 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 507522003376 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 507522003377 Hexamer/Pentamer interface [polypeptide binding]; other site 507522003378 central pore; other site 507522003379 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 507522003380 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 507522003381 Propanediol utilisation protein PduL; Region: PduL; pfam06130 507522003382 Propanediol utilisation protein PduL; Region: PduL; pfam06130 507522003383 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522003384 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 507522003385 Hexamer interface [polypeptide binding]; other site 507522003386 Hexagonal pore residue; other site 507522003387 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522003388 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 507522003389 Hexamer interface [polypeptide binding]; other site 507522003390 Putative hexagonal pore residue; other site 507522003391 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 507522003392 Cell division protein FtsA; Region: FtsA; cl17206 507522003393 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 507522003394 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 507522003395 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 507522003396 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 507522003397 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 507522003398 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 507522003399 alpha-beta subunit interface [polypeptide binding]; other site 507522003400 alpha-gamma subunit interface [polypeptide binding]; other site 507522003401 active site 507522003402 substrate and K+ binding site; other site 507522003403 K+ binding site [ion binding]; other site 507522003404 cobalamin binding site [chemical binding]; other site 507522003405 propanediol utilization protein PduB; Provisional; Region: PRK15415 507522003406 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 507522003407 putative hexamer interface [polypeptide binding]; other site 507522003408 putative hexagonal pore; other site 507522003409 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 507522003410 putative hexamer interface [polypeptide binding]; other site 507522003411 putative hexagonal pore; other site 507522003412 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522003413 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 507522003414 Hexamer interface [polypeptide binding]; other site 507522003415 Putative hexagonal pore residue; other site 507522003416 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 507522003417 amphipathic channel; other site 507522003418 Asn-Pro-Ala signature motifs; other site 507522003419 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 507522003420 Sensory domain found in PocR; Region: PocR; pfam10114 507522003421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522003422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522003423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522003424 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 507522003425 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 507522003426 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 507522003427 catalytic triad [active] 507522003428 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 507522003429 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 507522003430 Precorrin-8X methylmutase; Region: CbiC; pfam02570 507522003431 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 507522003432 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 507522003433 active site 507522003434 putative homodimer interface [polypeptide binding]; other site 507522003435 SAM binding site [chemical binding]; other site 507522003436 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 507522003437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522003438 S-adenosylmethionine binding site [chemical binding]; other site 507522003439 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 507522003440 active site 507522003441 SAM binding site [chemical binding]; other site 507522003442 homodimer interface [polypeptide binding]; other site 507522003443 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 507522003444 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 507522003445 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 507522003446 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 507522003447 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 507522003448 active site 507522003449 SAM binding site [chemical binding]; other site 507522003450 homodimer interface [polypeptide binding]; other site 507522003451 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 507522003452 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 507522003453 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 507522003454 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 507522003455 active site 507522003456 C-terminal domain interface [polypeptide binding]; other site 507522003457 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 507522003458 active site 507522003459 N-terminal domain interface [polypeptide binding]; other site 507522003460 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 507522003461 active site 507522003462 SAM binding site [chemical binding]; other site 507522003463 homodimer interface [polypeptide binding]; other site 507522003464 cobalt transport protein CbiM; Validated; Region: PRK08319 507522003465 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 507522003466 cobalt transport protein CbiN; Provisional; Region: PRK02898 507522003467 cobalt transport protein CbiQ; Provisional; Region: PRK15485 507522003468 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 507522003469 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 507522003470 Walker A/P-loop; other site 507522003471 ATP binding site [chemical binding]; other site 507522003472 Q-loop/lid; other site 507522003473 ABC transporter signature motif; other site 507522003474 Walker B; other site 507522003475 D-loop; other site 507522003476 H-loop/switch region; other site 507522003477 cobyric acid synthase; Provisional; Region: PRK00784 507522003478 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522003479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522003480 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 507522003481 catalytic triad [active] 507522003482 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 507522003483 homotrimer interface [polypeptide binding]; other site 507522003484 Walker A motif; other site 507522003485 GTP binding site [chemical binding]; other site 507522003486 Walker B motif; other site 507522003487 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 507522003488 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 507522003489 putative dimer interface [polypeptide binding]; other site 507522003490 active site pocket [active] 507522003491 putative cataytic base [active] 507522003492 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 507522003493 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 507522003494 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 507522003495 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 507522003496 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 507522003497 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 507522003498 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 507522003499 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 507522003500 PGAP1-like protein; Region: PGAP1; pfam07819 507522003501 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 507522003502 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 507522003503 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 507522003504 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 507522003505 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 507522003506 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 507522003507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522003508 ligand binding site [chemical binding]; other site 507522003509 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 507522003510 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 507522003511 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 507522003512 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 507522003513 murein transglycosylase A; Provisional; Region: mltA; PRK11162 507522003514 MltA specific insert domain; Region: MltA; pfam03562 507522003515 3D domain; Region: 3D; pfam06725 507522003516 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 507522003517 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 507522003518 putative ATP binding site [chemical binding]; other site 507522003519 putative substrate interface [chemical binding]; other site 507522003520 Fe-S metabolism associated domain; Region: SufE; cl00951 507522003521 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 507522003522 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 507522003523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522003524 catalytic residue [active] 507522003525 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 507522003526 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 507522003527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003528 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522003529 dimerization interface [polypeptide binding]; other site 507522003530 substrate binding pocket [chemical binding]; other site 507522003531 hypothetical protein; Provisional; Region: PRK10873 507522003532 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 507522003533 FtsJ-like methyltransferase; Region: FtsJ; cl17430 507522003534 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 507522003535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522003536 DNA-binding site [nucleotide binding]; DNA binding site 507522003537 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522003538 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 507522003539 L-fuculokinase; Provisional; Region: PRK10331 507522003540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 507522003541 nucleotide binding site [chemical binding]; other site 507522003542 L-fucose isomerase; Provisional; Region: fucI; PRK10991 507522003543 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 507522003544 hexamer (dimer of trimers) interface [polypeptide binding]; other site 507522003545 trimer interface [polypeptide binding]; other site 507522003546 substrate binding site [chemical binding]; other site 507522003547 Mn binding site [ion binding]; other site 507522003548 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 507522003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003550 putative substrate translocation pore; other site 507522003551 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 507522003552 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 507522003553 intersubunit interface [polypeptide binding]; other site 507522003554 active site 507522003555 Zn2+ binding site [ion binding]; other site 507522003556 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 507522003557 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 507522003558 dimer interface [polypeptide binding]; other site 507522003559 active site 507522003560 metal binding site [ion binding]; metal-binding site 507522003561 flap endonuclease-like protein; Provisional; Region: PRK09482 507522003562 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 507522003563 active site 507522003564 metal binding site 1 [ion binding]; metal-binding site 507522003565 putative 5' ssDNA interaction site; other site 507522003566 metal binding site 3; metal-binding site 507522003567 metal binding site 2 [ion binding]; metal-binding site 507522003568 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 507522003569 putative DNA binding site [nucleotide binding]; other site 507522003570 putative metal binding site [ion binding]; other site 507522003571 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 507522003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522003573 Walker A motif; other site 507522003574 ATP binding site [chemical binding]; other site 507522003575 Walker B motif; other site 507522003576 arginine finger; other site 507522003577 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522003578 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 507522003579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522003580 substrate binding pocket [chemical binding]; other site 507522003581 membrane-bound complex binding site; other site 507522003582 hinge residues; other site 507522003583 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 507522003584 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 507522003585 active site 507522003586 dimer interface [polypeptide binding]; other site 507522003587 non-prolyl cis peptide bond; other site 507522003588 insertion regions; other site 507522003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 507522003590 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 507522003591 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 507522003592 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 507522003593 active site 507522003594 non-prolyl cis peptide bond; other site 507522003595 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 507522003596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522003597 Walker A/P-loop; other site 507522003598 ATP binding site [chemical binding]; other site 507522003599 Q-loop/lid; other site 507522003600 ABC transporter signature motif; other site 507522003601 Walker B; other site 507522003602 D-loop; other site 507522003603 H-loop/switch region; other site 507522003604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522003605 dimer interface [polypeptide binding]; other site 507522003606 conserved gate region; other site 507522003607 ABC-ATPase subunit interface; other site 507522003608 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 507522003609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003610 putative substrate translocation pore; other site 507522003611 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 507522003612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003613 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 507522003614 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 507522003615 Flavin binding site [chemical binding]; other site 507522003616 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 507522003617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522003618 substrate binding pocket [chemical binding]; other site 507522003619 membrane-bound complex binding site; other site 507522003620 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 507522003621 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 507522003622 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 507522003623 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 507522003624 serine transporter; Region: stp; TIGR00814 507522003625 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 507522003626 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 507522003627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 507522003628 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 507522003629 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 507522003630 SecY interacting protein Syd; Provisional; Region: PRK04968 507522003631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 507522003632 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 507522003633 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 507522003634 probable active site [active] 507522003635 flavodoxin; Provisional; Region: PRK08105 507522003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003637 D-galactonate transporter; Region: 2A0114; TIGR00893 507522003638 putative substrate translocation pore; other site 507522003639 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 507522003640 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 507522003641 active site 507522003642 tetramer interface [polypeptide binding]; other site 507522003643 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 507522003644 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 507522003645 active site 507522003646 tetramer interface [polypeptide binding]; other site 507522003647 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 507522003648 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 507522003649 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 507522003650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522003651 dimerization interface [polypeptide binding]; other site 507522003652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522003653 dimer interface [polypeptide binding]; other site 507522003654 phosphorylation site [posttranslational modification] 507522003655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522003656 ATP binding site [chemical binding]; other site 507522003657 Mg2+ binding site [ion binding]; other site 507522003658 G-X-G motif; other site 507522003659 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 507522003660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522003661 active site 507522003662 phosphorylation site [posttranslational modification] 507522003663 intermolecular recognition site; other site 507522003664 dimerization interface [polypeptide binding]; other site 507522003665 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 507522003666 putative binding surface; other site 507522003667 active site 507522003668 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 507522003669 TRAM domain; Region: TRAM; pfam01938 507522003670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522003671 S-adenosylmethionine binding site [chemical binding]; other site 507522003672 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 507522003673 HD domain; Region: HD_4; pfam13328 507522003674 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 507522003675 synthetase active site [active] 507522003676 NTP binding site [chemical binding]; other site 507522003677 metal binding site [ion binding]; metal-binding site 507522003678 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 507522003679 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 507522003680 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 507522003681 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 507522003682 homodimer interface [polypeptide binding]; other site 507522003683 metal binding site [ion binding]; metal-binding site 507522003684 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 507522003685 homodimer interface [polypeptide binding]; other site 507522003686 active site 507522003687 putative chemical substrate binding site [chemical binding]; other site 507522003688 metal binding site [ion binding]; metal-binding site 507522003689 CTP synthetase; Validated; Region: pyrG; PRK05380 507522003690 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 507522003691 Catalytic site [active] 507522003692 active site 507522003693 UTP binding site [chemical binding]; other site 507522003694 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 507522003695 active site 507522003696 putative oxyanion hole; other site 507522003697 catalytic triad [active] 507522003698 enolase; Provisional; Region: eno; PRK00077 507522003699 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 507522003700 dimer interface [polypeptide binding]; other site 507522003701 metal binding site [ion binding]; metal-binding site 507522003702 substrate binding pocket [chemical binding]; other site 507522003703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522003704 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 507522003705 NAD(P) binding site [chemical binding]; other site 507522003706 active site 507522003707 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 507522003708 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 507522003709 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 507522003710 active site 507522003711 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 507522003712 Flavodoxin; Region: Flavodoxin_1; pfam00258 507522003713 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 507522003714 FAD binding pocket [chemical binding]; other site 507522003715 FAD binding motif [chemical binding]; other site 507522003716 catalytic residues [active] 507522003717 NAD binding pocket [chemical binding]; other site 507522003718 phosphate binding motif [ion binding]; other site 507522003719 beta-alpha-beta structure motif; other site 507522003720 sulfite reductase subunit beta; Provisional; Region: PRK13504 507522003721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522003722 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522003723 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 507522003724 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 507522003725 Active Sites [active] 507522003726 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 507522003727 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 507522003728 metal binding site [ion binding]; metal-binding site 507522003729 siroheme synthase; Provisional; Region: cysG; PRK10637 507522003730 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 507522003731 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 507522003732 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 507522003733 active site 507522003734 SAM binding site [chemical binding]; other site 507522003735 homodimer interface [polypeptide binding]; other site 507522003736 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 507522003737 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 507522003738 Active Sites [active] 507522003739 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 507522003740 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 507522003741 CysD dimerization site [polypeptide binding]; other site 507522003742 G1 box; other site 507522003743 putative GEF interaction site [polypeptide binding]; other site 507522003744 GTP/Mg2+ binding site [chemical binding]; other site 507522003745 Switch I region; other site 507522003746 G2 box; other site 507522003747 G3 box; other site 507522003748 Switch II region; other site 507522003749 G4 box; other site 507522003750 G5 box; other site 507522003751 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 507522003752 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 507522003753 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 507522003754 ligand-binding site [chemical binding]; other site 507522003755 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 507522003756 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 507522003757 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 507522003758 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 507522003759 substrate binding site; other site 507522003760 dimer interface; other site 507522003761 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 507522003762 homotrimer interaction site [polypeptide binding]; other site 507522003763 zinc binding site [ion binding]; other site 507522003764 CDP-binding sites; other site 507522003765 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 507522003766 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 507522003767 Permutation of conserved domain; other site 507522003768 active site 507522003769 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 507522003770 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 507522003771 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 507522003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522003773 S-adenosylmethionine binding site [chemical binding]; other site 507522003774 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 507522003775 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522003776 Peptidase family M23; Region: Peptidase_M23; pfam01551 507522003777 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 507522003778 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 507522003779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 507522003780 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 507522003781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 507522003782 DNA binding residues [nucleotide binding] 507522003783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 507522003784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522003785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003786 putative substrate translocation pore; other site 507522003787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522003788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522003790 putative effector binding pocket; other site 507522003791 dimerization interface [polypeptide binding]; other site 507522003792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522003793 MarR family; Region: MarR_2; cl17246 507522003794 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 507522003795 Flavoprotein; Region: Flavoprotein; pfam02441 507522003796 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 507522003797 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 507522003798 Hok/gef family; Region: HOK_GEF; pfam01848 507522003799 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 507522003800 MutS domain I; Region: MutS_I; pfam01624 507522003801 MutS domain II; Region: MutS_II; pfam05188 507522003802 MutS domain III; Region: MutS_III; pfam05192 507522003803 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 507522003804 Walker A/P-loop; other site 507522003805 ATP binding site [chemical binding]; other site 507522003806 Q-loop/lid; other site 507522003807 ABC transporter signature motif; other site 507522003808 Walker B; other site 507522003809 D-loop; other site 507522003810 H-loop/switch region; other site 507522003811 Fic/DOC family; Region: Fic; pfam02661 507522003812 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 507522003813 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522003814 Walker A/P-loop; other site 507522003815 ATP binding site [chemical binding]; other site 507522003816 Q-loop/lid; other site 507522003817 ABC transporter signature motif; other site 507522003818 Walker B; other site 507522003819 D-loop; other site 507522003820 H-loop/switch region; other site 507522003821 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522003822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522003823 ABC-ATPase subunit interface; other site 507522003824 dimer interface [polypeptide binding]; other site 507522003825 putative PBP binding regions; other site 507522003826 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 507522003827 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 507522003828 putative hemin binding site; other site 507522003829 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 507522003830 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 507522003831 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 507522003832 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 507522003833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522003834 N-terminal plug; other site 507522003835 ligand-binding site [chemical binding]; other site 507522003836 Rdx family; Region: Rdx; cl01407 507522003837 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 507522003838 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522003839 PYR/PP interface [polypeptide binding]; other site 507522003840 dimer interface [polypeptide binding]; other site 507522003841 TPP binding site [chemical binding]; other site 507522003842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522003843 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 507522003844 TPP-binding site [chemical binding]; other site 507522003845 Membrane transport protein; Region: Mem_trans; cl09117 507522003846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522003847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522003848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522003849 dimerization interface [polypeptide binding]; other site 507522003850 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 507522003851 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 507522003852 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522003853 ABC-ATPase subunit interface; other site 507522003854 dimer interface [polypeptide binding]; other site 507522003855 putative PBP binding regions; other site 507522003856 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 507522003857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522003858 ABC-ATPase subunit interface; other site 507522003859 dimer interface [polypeptide binding]; other site 507522003860 putative PBP binding regions; other site 507522003861 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 507522003862 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 507522003863 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 507522003864 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 507522003865 metal binding site [ion binding]; metal-binding site 507522003866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522003867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522003868 DNA binding site [nucleotide binding] 507522003869 domain linker motif; other site 507522003870 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 507522003871 ligand binding site [chemical binding]; other site 507522003872 dimerization interface [polypeptide binding]; other site 507522003873 fructokinase; Reviewed; Region: PRK09557 507522003874 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522003875 nucleotide binding site [chemical binding]; other site 507522003876 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 507522003877 methionine cluster; other site 507522003878 active site 507522003879 phosphorylation site [posttranslational modification] 507522003880 metal binding site [ion binding]; metal-binding site 507522003881 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522003882 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522003883 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522003884 active site 507522003885 P-loop; other site 507522003886 phosphorylation site [posttranslational modification] 507522003887 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522003888 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522003889 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 507522003890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 507522003891 Interdomain contacts; other site 507522003892 Cytokine receptor motif; other site 507522003893 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 507522003894 putative metal binding site [ion binding]; other site 507522003895 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 507522003896 beta-galactosidase; Region: BGL; TIGR03356 507522003897 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 507522003898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 507522003899 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 507522003900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522003901 Walker A motif; other site 507522003902 ATP binding site [chemical binding]; other site 507522003903 Walker B motif; other site 507522003904 arginine finger; other site 507522003905 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 507522003906 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 507522003907 dimerization interface [polypeptide binding]; other site 507522003908 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 507522003909 ATP binding site [chemical binding]; other site 507522003910 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 507522003911 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 507522003912 hydrogenase assembly chaperone; Provisional; Region: PRK10409 507522003913 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 507522003914 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 507522003915 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 507522003916 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 507522003917 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 507522003918 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 507522003919 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 507522003920 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 507522003921 NADH dehydrogenase; Region: NADHdh; cl00469 507522003922 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 507522003923 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 507522003924 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 507522003925 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 507522003926 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522003927 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 507522003928 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 507522003929 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 507522003930 nickel binding site [ion binding]; other site 507522003931 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 507522003932 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 507522003933 beta-galactosidase; Region: BGL; TIGR03356 507522003934 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 507522003935 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522003936 active site turn [active] 507522003937 phosphorylation site [posttranslational modification] 507522003938 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 507522003939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522003940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522003941 DNA binding site [nucleotide binding] 507522003942 domain linker motif; other site 507522003943 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 507522003944 dimerization interface (closed form) [polypeptide binding]; other site 507522003945 ligand binding site [chemical binding]; other site 507522003946 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 507522003947 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 507522003948 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 507522003949 Acylphosphatase; Region: Acylphosphatase; pfam00708 507522003950 HypF finger; Region: zf-HYPF; pfam07503 507522003951 HypF finger; Region: zf-HYPF; pfam07503 507522003952 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 507522003953 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 507522003954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522003955 putative substrate translocation pore; other site 507522003956 Transcriptional regulator [Transcription]; Region: IclR; COG1414 507522003957 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522003958 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522003959 hypothetical protein; Validated; Region: PRK06201 507522003960 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 507522003961 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 507522003962 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 507522003963 ligand binding site [chemical binding]; other site 507522003964 NAD binding site [chemical binding]; other site 507522003965 dimerization interface [polypeptide binding]; other site 507522003966 catalytic site [active] 507522003967 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 507522003968 UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234 507522003969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522003970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522003971 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 507522003972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 507522003973 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 507522003974 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 507522003975 iron binding site [ion binding]; other site 507522003976 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 507522003977 GAF domain; Region: GAF; pfam01590 507522003978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522003979 Walker A motif; other site 507522003980 ATP binding site [chemical binding]; other site 507522003981 Walker B motif; other site 507522003982 arginine finger; other site 507522003983 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 507522003984 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 507522003985 putative active site [active] 507522003986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 507522003987 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 507522003988 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 507522003989 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522003990 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 507522003991 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 507522003992 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 507522003993 putative NAD(P) binding site [chemical binding]; other site 507522003994 active site 507522003995 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 507522003996 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 507522003997 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 507522003998 Nucleoside recognition; Region: Gate; pfam07670 507522003999 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 507522004000 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 507522004001 Transglycosylase SLT domain; Region: SLT_2; pfam13406 507522004002 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522004003 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522004004 catalytic residue [active] 507522004005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 507522004006 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 507522004007 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 507522004008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522004009 ABC-ATPase subunit interface; other site 507522004010 dimer interface [polypeptide binding]; other site 507522004011 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 507522004012 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 507522004013 metal binding site [ion binding]; metal-binding site 507522004014 hypothetical protein; Validated; Region: PRK03661 507522004015 recombinase A; Provisional; Region: recA; PRK09354 507522004016 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 507522004017 hexamer interface [polypeptide binding]; other site 507522004018 Walker A motif; other site 507522004019 ATP binding site [chemical binding]; other site 507522004020 Walker B motif; other site 507522004021 recombination regulator RecX; Reviewed; Region: recX; PRK00117 507522004022 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 507522004023 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 507522004024 motif 1; other site 507522004025 active site 507522004026 motif 2; other site 507522004027 motif 3; other site 507522004028 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 507522004029 DHHA1 domain; Region: DHHA1; pfam02272 507522004030 carbon storage regulator; Provisional; Region: PRK01712 507522004031 BON domain; Region: BON; pfam04972 507522004032 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 507522004033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522004034 motif II; other site 507522004035 Predicted membrane protein [Function unknown]; Region: COG1238 507522004036 glutamate--cysteine ligase; Provisional; Region: PRK02107 507522004037 S-ribosylhomocysteinase; Provisional; Region: PRK02260 507522004038 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522004039 Helix-turn-helix domain; Region: HTH_18; pfam12833 507522004040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522004041 2-isopropylmalate synthase; Validated; Region: PRK03739 507522004042 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 507522004043 active site 507522004044 catalytic residues [active] 507522004045 metal binding site [ion binding]; metal-binding site 507522004046 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 507522004047 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 507522004048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004049 putative substrate translocation pore; other site 507522004050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004051 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 507522004052 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522004053 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522004054 transcriptional repressor MprA; Provisional; Region: PRK10870 507522004055 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522004056 putative L-valine exporter; Provisional; Region: PRK10408 507522004057 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 507522004058 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 507522004059 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 507522004060 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 507522004061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522004062 dimer interface [polypeptide binding]; other site 507522004063 conserved gate region; other site 507522004064 putative PBP binding loops; other site 507522004065 ABC-ATPase subunit interface; other site 507522004066 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 507522004067 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 507522004068 Walker A/P-loop; other site 507522004069 ATP binding site [chemical binding]; other site 507522004070 Q-loop/lid; other site 507522004071 ABC transporter signature motif; other site 507522004072 Walker B; other site 507522004073 D-loop; other site 507522004074 H-loop/switch region; other site 507522004075 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 507522004076 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 507522004077 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 507522004078 dimer interface [polypeptide binding]; other site 507522004079 putative radical transfer pathway; other site 507522004080 diiron center [ion binding]; other site 507522004081 tyrosyl radical; other site 507522004082 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 507522004083 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 507522004084 Class I ribonucleotide reductase; Region: RNR_I; cd01679 507522004085 active site 507522004086 dimer interface [polypeptide binding]; other site 507522004087 catalytic residues [active] 507522004088 effector binding site; other site 507522004089 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 507522004090 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 507522004091 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 507522004092 catalytic residues [active] 507522004093 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 507522004094 Uncharacterized conserved protein [Function unknown]; Region: COG2128 507522004095 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522004096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522004097 DNA-binding site [nucleotide binding]; DNA binding site 507522004098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522004099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522004100 homodimer interface [polypeptide binding]; other site 507522004101 catalytic residue [active] 507522004102 hypothetical protein; Provisional; Region: PRK10132 507522004103 hypothetical protein; Provisional; Region: PRK10556 507522004104 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 507522004105 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 507522004106 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 507522004107 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 507522004108 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 507522004109 active site residue [active] 507522004110 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 507522004111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522004112 dimerization interface [polypeptide binding]; other site 507522004113 putative DNA binding site [nucleotide binding]; other site 507522004114 Transcriptional regulators [Transcription]; Region: MarR; COG1846 507522004115 putative Zn2+ binding site [ion binding]; other site 507522004116 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 507522004117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522004118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004119 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 507522004120 putative effector binding pocket; other site 507522004121 putative dimerization interface [polypeptide binding]; other site 507522004122 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 507522004123 active site 507522004124 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 507522004125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522004126 Walker A motif; other site 507522004127 ATP binding site [chemical binding]; other site 507522004128 Walker B motif; other site 507522004129 arginine finger; other site 507522004130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522004131 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 507522004132 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 507522004133 NAD(P) binding site [chemical binding]; other site 507522004134 catalytic residues [active] 507522004135 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522004136 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522004137 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522004138 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522004139 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522004140 PapC N-terminal domain; Region: PapC_N; pfam13954 507522004141 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522004142 PapC C-terminal domain; Region: PapC_C; pfam13953 507522004143 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522004144 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522004145 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522004146 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522004147 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522004148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522004149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522004150 substrate binding pocket [chemical binding]; other site 507522004151 membrane-bound complex binding site; other site 507522004152 hinge residues; other site 507522004153 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522004154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522004155 NAD(P) binding site [chemical binding]; other site 507522004156 active site 507522004157 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 507522004158 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 507522004159 putative ligand binding site [chemical binding]; other site 507522004160 NAD binding site [chemical binding]; other site 507522004161 dimerization interface [polypeptide binding]; other site 507522004162 catalytic site [active] 507522004163 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 507522004164 intersubunit interface [polypeptide binding]; other site 507522004165 active site 507522004166 Zn2+ binding site [ion binding]; other site 507522004167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522004168 dimer interface [polypeptide binding]; other site 507522004169 conserved gate region; other site 507522004170 ABC-ATPase subunit interface; other site 507522004171 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522004172 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522004173 Walker A/P-loop; other site 507522004174 ATP binding site [chemical binding]; other site 507522004175 Q-loop/lid; other site 507522004176 ABC transporter signature motif; other site 507522004177 Walker B; other site 507522004178 D-loop; other site 507522004179 H-loop/switch region; other site 507522004180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522004181 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522004182 substrate binding pocket [chemical binding]; other site 507522004183 membrane-bound complex binding site; other site 507522004184 hinge residues; other site 507522004185 oxidase reductase; Provisional; Region: PTZ00273 507522004186 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 507522004187 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 507522004188 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 507522004189 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 507522004190 agmatinase; Region: agmatinase; TIGR01230 507522004191 oligomer interface [polypeptide binding]; other site 507522004192 putative active site [active] 507522004193 Mn binding site [ion binding]; other site 507522004194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522004195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522004197 dimerization interface [polypeptide binding]; other site 507522004198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 507522004199 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 507522004200 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 507522004201 active site 507522004202 Predicted transcriptional regulator [Transcription]; Region: COG1959 507522004203 Transcriptional regulator; Region: Rrf2; pfam02082 507522004204 Transcriptional regulator; Region: Rrf2; cl17282 507522004205 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522004206 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522004207 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522004208 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522004209 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 507522004210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522004211 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 507522004212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522004213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004214 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522004215 putative effector binding pocket; other site 507522004216 putative dimerization interface [polypeptide binding]; other site 507522004217 Cupin domain; Region: Cupin_2; cl17218 507522004218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522004219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522004220 non-specific DNA binding site [nucleotide binding]; other site 507522004221 salt bridge; other site 507522004222 sequence-specific DNA binding site [nucleotide binding]; other site 507522004223 Cupin domain; Region: Cupin_2; cl17218 507522004224 short chain dehydrogenase; Provisional; Region: PRK06500 507522004225 classical (c) SDRs; Region: SDR_c; cd05233 507522004226 NAD(P) binding site [chemical binding]; other site 507522004227 active site 507522004228 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 507522004229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522004230 Walker A/P-loop; other site 507522004231 ATP binding site [chemical binding]; other site 507522004232 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 507522004233 active site 507522004234 metal binding site [ion binding]; metal-binding site 507522004235 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 507522004236 Family description; Region: UvrD_C_2; pfam13538 507522004237 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 507522004238 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 507522004239 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 507522004240 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 507522004241 SmpB-tmRNA interface; other site 507522004242 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 507522004243 putative coenzyme Q binding site [chemical binding]; other site 507522004244 hypothetical protein; Validated; Region: PRK01777 507522004245 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 507522004246 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 507522004247 recombination and repair protein; Provisional; Region: PRK10869 507522004248 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 507522004249 Walker A/P-loop; other site 507522004250 ATP binding site [chemical binding]; other site 507522004251 Q-loop/lid; other site 507522004252 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 507522004253 ABC transporter signature motif; other site 507522004254 Walker B; other site 507522004255 D-loop; other site 507522004256 H-loop/switch region; other site 507522004257 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 507522004258 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 507522004259 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 507522004260 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 507522004261 dimer interface [polypeptide binding]; other site 507522004262 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 507522004263 hypothetical protein; Provisional; Region: PRK11573 507522004264 Domain of unknown function DUF21; Region: DUF21; pfam01595 507522004265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 507522004266 Transporter associated domain; Region: CorC_HlyC; smart01091 507522004267 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 507522004268 signal recognition particle protein; Provisional; Region: PRK10867 507522004269 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 507522004270 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 507522004271 P loop; other site 507522004272 GTP binding site [chemical binding]; other site 507522004273 Signal peptide binding domain; Region: SRP_SPB; pfam02978 507522004274 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 507522004275 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 507522004276 RimM N-terminal domain; Region: RimM; pfam01782 507522004277 PRC-barrel domain; Region: PRC; pfam05239 507522004278 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 507522004279 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 507522004280 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 507522004281 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 507522004282 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 507522004283 putative outer membrane lipoprotein; Provisional; Region: PRK09967 507522004284 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522004285 ligand binding site [chemical binding]; other site 507522004286 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 507522004287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522004288 metal binding site [ion binding]; metal-binding site 507522004289 active site 507522004290 I-site; other site 507522004291 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 507522004292 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 507522004293 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 507522004294 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 507522004295 Chorismate mutase type II; Region: CM_2; cl00693 507522004296 prephenate dehydrogenase; Validated; Region: PRK08507 507522004297 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 507522004298 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 507522004299 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 507522004300 Prephenate dehydratase; Region: PDT; pfam00800 507522004301 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 507522004302 putative L-Phe binding site [chemical binding]; other site 507522004303 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 507522004304 30S subunit binding site; other site 507522004305 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 507522004306 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 507522004307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522004308 RNA binding surface [nucleotide binding]; other site 507522004309 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 507522004310 active site 507522004311 hypothetical protein; Provisional; Region: PRK10723 507522004312 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 507522004313 protein disaggregation chaperone; Provisional; Region: PRK10865 507522004314 Clp amino terminal domain; Region: Clp_N; pfam02861 507522004315 Clp amino terminal domain; Region: Clp_N; pfam02861 507522004316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522004317 Walker A motif; other site 507522004318 ATP binding site [chemical binding]; other site 507522004319 Walker B motif; other site 507522004320 arginine finger; other site 507522004321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522004322 Walker A motif; other site 507522004323 ATP binding site [chemical binding]; other site 507522004324 Walker B motif; other site 507522004325 arginine finger; other site 507522004326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 507522004327 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 507522004328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004329 putative substrate translocation pore; other site 507522004330 lipoprotein; Provisional; Region: PRK10759 507522004331 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 507522004332 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 507522004333 domain interface [polypeptide binding]; other site 507522004334 putative active site [active] 507522004335 catalytic site [active] 507522004336 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 507522004337 domain interface [polypeptide binding]; other site 507522004338 putative active site [active] 507522004339 catalytic site [active] 507522004340 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 507522004341 CoA binding domain; Region: CoA_binding_2; pfam13380 507522004342 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 507522004343 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 507522004344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522004345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522004346 Uncharacterized conserved protein [Function unknown]; Region: COG3148 507522004347 thioredoxin 2; Provisional; Region: PRK10996 507522004348 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 507522004349 catalytic residues [active] 507522004350 putative methyltransferase; Provisional; Region: PRK10864 507522004351 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 507522004352 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 507522004353 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 507522004354 ligand binding site [chemical binding]; other site 507522004355 active site 507522004356 UGI interface [polypeptide binding]; other site 507522004357 catalytic site [active] 507522004358 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 507522004359 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 507522004360 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 507522004361 ATP binding site [chemical binding]; other site 507522004362 Mg++ binding site [ion binding]; other site 507522004363 motif III; other site 507522004364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522004365 nucleotide binding region [chemical binding]; other site 507522004366 ATP-binding site [chemical binding]; other site 507522004367 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 507522004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 507522004369 L-aspartate oxidase; Provisional; Region: PRK09077 507522004370 L-aspartate oxidase; Provisional; Region: PRK06175 507522004371 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 507522004372 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 507522004373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 507522004374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 507522004375 DNA binding residues [nucleotide binding] 507522004376 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 507522004377 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 507522004378 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 507522004379 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 507522004380 anti-sigma E factor; Provisional; Region: rseB; PRK09455 507522004381 SoxR reducing system protein RseC; Provisional; Region: PRK10862 507522004382 GTP-binding protein LepA; Provisional; Region: PRK05433 507522004383 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 507522004384 G1 box; other site 507522004385 putative GEF interaction site [polypeptide binding]; other site 507522004386 GTP/Mg2+ binding site [chemical binding]; other site 507522004387 Switch I region; other site 507522004388 G2 box; other site 507522004389 G3 box; other site 507522004390 Switch II region; other site 507522004391 G4 box; other site 507522004392 G5 box; other site 507522004393 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 507522004394 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 507522004395 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 507522004396 signal peptidase I; Provisional; Region: PRK10861 507522004397 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 507522004398 Catalytic site [active] 507522004399 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 507522004400 ribonuclease III; Reviewed; Region: rnc; PRK00102 507522004401 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 507522004402 dimerization interface [polypeptide binding]; other site 507522004403 active site 507522004404 metal binding site [ion binding]; metal-binding site 507522004405 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 507522004406 dsRNA binding site [nucleotide binding]; other site 507522004407 GTPase Era; Reviewed; Region: era; PRK00089 507522004408 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 507522004409 G1 box; other site 507522004410 GTP/Mg2+ binding site [chemical binding]; other site 507522004411 Switch I region; other site 507522004412 G2 box; other site 507522004413 Switch II region; other site 507522004414 G3 box; other site 507522004415 G4 box; other site 507522004416 G5 box; other site 507522004417 KH domain; Region: KH_2; pfam07650 507522004418 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 507522004419 Recombination protein O N terminal; Region: RecO_N; pfam11967 507522004420 Recombination protein O C terminal; Region: RecO_C; pfam02565 507522004421 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 507522004422 active site 507522004423 hydrophilic channel; other site 507522004424 dimerization interface [polypeptide binding]; other site 507522004425 catalytic residues [active] 507522004426 active site lid [active] 507522004427 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 507522004428 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 507522004429 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522004430 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 507522004431 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522004432 putative active site [active] 507522004433 hypothetical protein; Provisional; Region: PRK11590 507522004434 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 507522004435 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 507522004436 nucleoside/Zn binding site; other site 507522004437 dimer interface [polypeptide binding]; other site 507522004438 catalytic motif [active] 507522004439 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 507522004440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522004441 substrate binding pocket [chemical binding]; other site 507522004442 membrane-bound complex binding site; other site 507522004443 hinge residues; other site 507522004444 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522004445 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522004446 catalytic residue [active] 507522004447 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 507522004448 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 507522004449 dimerization interface [polypeptide binding]; other site 507522004450 ATP binding site [chemical binding]; other site 507522004451 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 507522004452 dimerization interface [polypeptide binding]; other site 507522004453 ATP binding site [chemical binding]; other site 507522004454 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 507522004455 putative active site [active] 507522004456 catalytic triad [active] 507522004457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 507522004458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522004459 dimer interface [polypeptide binding]; other site 507522004460 phosphorylation site [posttranslational modification] 507522004461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522004462 ATP binding site [chemical binding]; other site 507522004463 Mg2+ binding site [ion binding]; other site 507522004464 G-X-G motif; other site 507522004465 hypothetical protein; Provisional; Region: PRK10722 507522004466 response regulator GlrR; Provisional; Region: PRK15115 507522004467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522004468 active site 507522004469 phosphorylation site [posttranslational modification] 507522004470 intermolecular recognition site; other site 507522004471 dimerization interface [polypeptide binding]; other site 507522004472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522004473 Walker A motif; other site 507522004474 ATP binding site [chemical binding]; other site 507522004475 Walker B motif; other site 507522004476 arginine finger; other site 507522004477 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 507522004478 Nitrogen regulatory protein P-II; Region: P-II; smart00938 507522004479 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 507522004480 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 507522004481 heme-binding site [chemical binding]; other site 507522004482 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 507522004483 FAD binding pocket [chemical binding]; other site 507522004484 FAD binding motif [chemical binding]; other site 507522004485 phosphate binding motif [ion binding]; other site 507522004486 beta-alpha-beta structure motif; other site 507522004487 NAD binding pocket [chemical binding]; other site 507522004488 Heme binding pocket [chemical binding]; other site 507522004489 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 507522004490 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 507522004491 dimer interface [polypeptide binding]; other site 507522004492 active site 507522004493 glycine-pyridoxal phosphate binding site [chemical binding]; other site 507522004494 folate binding site [chemical binding]; other site 507522004495 Predicted membrane protein [Function unknown]; Region: COG2259 507522004496 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 507522004497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004498 putative substrate translocation pore; other site 507522004499 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 507522004500 PRD domain; Region: PRD; pfam00874 507522004501 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 507522004502 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 507522004503 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 507522004504 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 507522004505 active site 507522004506 dimerization interface [polypeptide binding]; other site 507522004507 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 507522004508 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 507522004509 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 507522004510 Rrf2 family protein; Region: rrf2_super; TIGR00738 507522004511 cysteine desulfurase; Provisional; Region: PRK14012 507522004512 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 507522004513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522004514 catalytic residue [active] 507522004515 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 507522004516 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 507522004517 trimerization site [polypeptide binding]; other site 507522004518 active site 507522004519 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 507522004520 co-chaperone HscB; Provisional; Region: hscB; PRK05014 507522004521 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 507522004522 HSP70 interaction site [polypeptide binding]; other site 507522004523 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 507522004524 chaperone protein HscA; Provisional; Region: hscA; PRK05183 507522004525 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 507522004526 nucleotide binding site [chemical binding]; other site 507522004527 putative NEF/HSP70 interaction site [polypeptide binding]; other site 507522004528 SBD interface [polypeptide binding]; other site 507522004529 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 507522004530 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522004531 catalytic loop [active] 507522004532 iron binding site [ion binding]; other site 507522004533 hypothetical protein; Provisional; Region: PRK10721 507522004534 aminopeptidase B; Provisional; Region: PRK05015 507522004535 Peptidase; Region: DUF3663; pfam12404 507522004536 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 507522004537 interface (dimer of trimers) [polypeptide binding]; other site 507522004538 Substrate-binding/catalytic site; other site 507522004539 Zn-binding sites [ion binding]; other site 507522004540 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 507522004541 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 507522004542 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 507522004543 active site residue [active] 507522004544 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 507522004545 active site residue [active] 507522004546 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 507522004547 MG2 domain; Region: A2M_N; pfam01835 507522004548 Alpha-2-macroglobulin family; Region: A2M; pfam00207 507522004549 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 507522004550 surface patch; other site 507522004551 thioester region; other site 507522004552 specificity defining residues; other site 507522004553 penicillin-binding protein 1C; Provisional; Region: PRK11240 507522004554 Transglycosylase; Region: Transgly; pfam00912 507522004555 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 507522004556 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 507522004557 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 507522004558 active site 507522004559 multimer interface [polypeptide binding]; other site 507522004560 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 507522004561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522004562 FeS/SAM binding site; other site 507522004563 cytoskeletal protein RodZ; Provisional; Region: PRK10856 507522004564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522004565 non-specific DNA binding site [nucleotide binding]; other site 507522004566 salt bridge; other site 507522004567 sequence-specific DNA binding site [nucleotide binding]; other site 507522004568 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 507522004569 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 507522004570 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 507522004571 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 507522004572 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 507522004573 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 507522004574 dimer interface [polypeptide binding]; other site 507522004575 motif 1; other site 507522004576 active site 507522004577 motif 2; other site 507522004578 motif 3; other site 507522004579 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 507522004580 anticodon binding site; other site 507522004581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 507522004582 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 507522004583 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 507522004584 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 507522004585 Trp docking motif [polypeptide binding]; other site 507522004586 GTP-binding protein Der; Reviewed; Region: PRK00093 507522004587 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 507522004588 G1 box; other site 507522004589 GTP/Mg2+ binding site [chemical binding]; other site 507522004590 Switch I region; other site 507522004591 G2 box; other site 507522004592 Switch II region; other site 507522004593 G3 box; other site 507522004594 G4 box; other site 507522004595 G5 box; other site 507522004596 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 507522004597 G1 box; other site 507522004598 GTP/Mg2+ binding site [chemical binding]; other site 507522004599 Switch I region; other site 507522004600 G2 box; other site 507522004601 G3 box; other site 507522004602 Switch II region; other site 507522004603 G4 box; other site 507522004604 G5 box; other site 507522004605 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522004606 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522004607 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 507522004608 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 507522004609 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 507522004610 generic binding surface II; other site 507522004611 generic binding surface I; other site 507522004612 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 507522004613 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 507522004614 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 507522004615 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 507522004616 active site 507522004617 GMP synthase; Reviewed; Region: guaA; PRK00074 507522004618 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 507522004619 AMP/PPi binding site [chemical binding]; other site 507522004620 candidate oxyanion hole; other site 507522004621 catalytic triad [active] 507522004622 potential glutamine specificity residues [chemical binding]; other site 507522004623 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 507522004624 ATP Binding subdomain [chemical binding]; other site 507522004625 Ligand Binding sites [chemical binding]; other site 507522004626 Dimerization subdomain; other site 507522004627 integrase; Provisional; Region: PRK09692 507522004628 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522004629 active site 507522004630 Int/Topo IB signature motif; other site 507522004631 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 507522004632 AAA domain; Region: AAA_25; pfam13481 507522004633 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 507522004634 Walker A motif; other site 507522004635 NTP binding site [chemical binding]; other site 507522004636 hexamer interface [polypeptide binding]; other site 507522004637 Walker B motif; other site 507522004638 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 507522004639 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 507522004640 TraC-like protein; Region: TraC; cl06725 507522004641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522004642 non-specific DNA binding site [nucleotide binding]; other site 507522004643 salt bridge; other site 507522004644 sequence-specific DNA binding site [nucleotide binding]; other site 507522004645 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 507522004646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522004647 active site 507522004648 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 507522004649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522004650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004651 putative substrate translocation pore; other site 507522004652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522004653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522004655 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 507522004656 MASE1; Region: MASE1; cl17823 507522004657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522004658 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 507522004659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522004660 exopolyphosphatase; Provisional; Region: PRK10854 507522004661 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 507522004662 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 507522004663 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 507522004664 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 507522004665 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 507522004666 domain interface [polypeptide binding]; other site 507522004667 active site 507522004668 catalytic site [active] 507522004669 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 507522004670 domain interface [polypeptide binding]; other site 507522004671 active site 507522004672 catalytic site [active] 507522004673 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 507522004674 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522004675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004676 putative substrate translocation pore; other site 507522004677 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 507522004678 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 507522004679 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 507522004680 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 507522004681 active site 507522004682 substrate binding site [chemical binding]; other site 507522004683 cosubstrate binding site; other site 507522004684 catalytic site [active] 507522004685 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 507522004686 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 507522004687 dimerization interface [polypeptide binding]; other site 507522004688 putative ATP binding site [chemical binding]; other site 507522004689 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 507522004690 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522004691 nucleotide binding site [chemical binding]; other site 507522004692 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 507522004693 beta-galactosidase; Region: BGL; TIGR03356 507522004694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522004695 active site 507522004696 uracil transporter; Provisional; Region: PRK10720 507522004697 DNA replication initiation factor; Provisional; Region: PRK08084 507522004698 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 507522004699 hypothetical protein; Provisional; Region: PRK09956 507522004700 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 507522004701 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 507522004702 ArsC family; Region: ArsC; pfam03960 507522004703 catalytic residues [active] 507522004704 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 507522004705 Peptidase family M48; Region: Peptidase_M48; cl12018 507522004706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 507522004707 Domain of unknown function DUF20; Region: UPF0118; pfam01594 507522004708 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 507522004709 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 507522004710 catalytic triad [active] 507522004711 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 507522004712 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 507522004713 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 507522004714 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 507522004715 dihydrodipicolinate synthase; Region: dapA; TIGR00674 507522004716 dimer interface [polypeptide binding]; other site 507522004717 active site 507522004718 catalytic residue [active] 507522004719 lipoprotein; Provisional; Region: PRK11679 507522004720 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 507522004721 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 507522004722 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 507522004723 ATP binding site [chemical binding]; other site 507522004724 active site 507522004725 substrate binding site [chemical binding]; other site 507522004726 Predicted metalloprotease [General function prediction only]; Region: COG2321 507522004727 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 507522004728 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 507522004729 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 507522004730 Helicase; Region: Helicase_RecD; pfam05127 507522004731 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 507522004732 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 507522004733 putative hydrolase; Provisional; Region: PRK11460 507522004734 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 507522004735 hypothetical protein; Provisional; Region: PRK13664 507522004736 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 507522004737 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 507522004738 metal binding site [ion binding]; metal-binding site 507522004739 dimer interface [polypeptide binding]; other site 507522004740 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 507522004741 ArsC family; Region: ArsC; pfam03960 507522004742 putative catalytic residues [active] 507522004743 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 507522004744 Protein export membrane protein; Region: SecD_SecF; cl14618 507522004745 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 507522004746 4Fe-4S binding domain; Region: Fer4; pfam00037 507522004747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522004748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522004749 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 507522004750 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 507522004751 dimer interface [polypeptide binding]; other site 507522004752 ADP-ribose binding site [chemical binding]; other site 507522004753 active site 507522004754 nudix motif; other site 507522004755 metal binding site [ion binding]; metal-binding site 507522004756 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 507522004757 transketolase; Reviewed; Region: PRK12753 507522004758 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522004759 TPP-binding site [chemical binding]; other site 507522004760 dimer interface [polypeptide binding]; other site 507522004761 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522004762 PYR/PP interface [polypeptide binding]; other site 507522004763 dimer interface [polypeptide binding]; other site 507522004764 TPP binding site [chemical binding]; other site 507522004765 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522004766 transaldolase-like protein; Provisional; Region: PTZ00411 507522004767 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 507522004768 active site 507522004769 dimer interface [polypeptide binding]; other site 507522004770 catalytic residue [active] 507522004771 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 507522004772 Malic enzyme, N-terminal domain; Region: malic; pfam00390 507522004773 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 507522004774 putative NAD(P) binding site [chemical binding]; other site 507522004775 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 507522004776 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 507522004777 putative hexamer interface [polypeptide binding]; other site 507522004778 putative hexagonal pore; other site 507522004779 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 507522004780 G1 box; other site 507522004781 GTP/Mg2+ binding site [chemical binding]; other site 507522004782 G2 box; other site 507522004783 Switch I region; other site 507522004784 G3 box; other site 507522004785 Switch II region; other site 507522004786 G4 box; other site 507522004787 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 507522004788 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 507522004789 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 507522004790 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 507522004791 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522004792 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522004793 Hexamer interface [polypeptide binding]; other site 507522004794 Hexagonal pore residue; other site 507522004795 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 507522004796 Hexamer/Pentamer interface [polypeptide binding]; other site 507522004797 central pore; other site 507522004798 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 507522004799 NAD(P) binding site [chemical binding]; other site 507522004800 catalytic residues [active] 507522004801 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 507522004802 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522004803 nucleotide binding site [chemical binding]; other site 507522004804 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 507522004805 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 507522004806 active site 507522004807 metal binding site [ion binding]; metal-binding site 507522004808 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 507522004809 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 507522004810 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 507522004811 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 507522004812 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 507522004813 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 507522004814 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 507522004815 putative hexamer interface [polypeptide binding]; other site 507522004816 putative hexagonal pore; other site 507522004817 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 507522004818 putative hexamer interface [polypeptide binding]; other site 507522004819 putative hexagonal pore; other site 507522004820 carboxysome structural protein EutK; Provisional; Region: PRK15466 507522004821 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522004822 Hexamer interface [polypeptide binding]; other site 507522004823 Hexagonal pore residue; other site 507522004824 transcriptional regulator EutR; Provisional; Region: PRK10130 507522004825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522004826 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 507522004827 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 507522004828 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 507522004829 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 507522004830 active site 507522004831 metal binding site [ion binding]; metal-binding site 507522004832 putative acetyltransferase; Provisional; Region: PRK03624 507522004833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522004834 Coenzyme A binding pocket [chemical binding]; other site 507522004835 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 507522004836 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 507522004837 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 507522004838 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 507522004839 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 507522004840 putative active site [active] 507522004841 thiosulfate transporter subunit; Provisional; Region: PRK10852 507522004842 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 507522004843 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 507522004844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522004845 dimer interface [polypeptide binding]; other site 507522004846 conserved gate region; other site 507522004847 putative PBP binding loops; other site 507522004848 ABC-ATPase subunit interface; other site 507522004849 sulfate transport protein; Provisional; Region: cysT; CHL00187 507522004850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522004851 dimer interface [polypeptide binding]; other site 507522004852 conserved gate region; other site 507522004853 putative PBP binding loops; other site 507522004854 ABC-ATPase subunit interface; other site 507522004855 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 507522004856 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 507522004857 Walker A/P-loop; other site 507522004858 ATP binding site [chemical binding]; other site 507522004859 Q-loop/lid; other site 507522004860 ABC transporter signature motif; other site 507522004861 Walker B; other site 507522004862 D-loop; other site 507522004863 H-loop/switch region; other site 507522004864 TOBE-like domain; Region: TOBE_3; pfam12857 507522004865 cysteine synthase B; Region: cysM; TIGR01138 507522004866 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 507522004867 dimer interface [polypeptide binding]; other site 507522004868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522004869 catalytic residue [active] 507522004870 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 507522004871 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 507522004872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522004873 DNA-binding site [nucleotide binding]; DNA binding site 507522004874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522004875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522004876 homodimer interface [polypeptide binding]; other site 507522004877 catalytic residue [active] 507522004878 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 507522004879 dimer interface [polypeptide binding]; other site 507522004880 pyridoxamine kinase; Validated; Region: PRK05756 507522004881 pyridoxal binding site [chemical binding]; other site 507522004882 ATP binding site [chemical binding]; other site 507522004883 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 507522004884 HPr interaction site; other site 507522004885 glycerol kinase (GK) interaction site [polypeptide binding]; other site 507522004886 active site 507522004887 phosphorylation site [posttranslational modification] 507522004888 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 507522004889 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 507522004890 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 507522004891 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 507522004892 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 507522004893 dimerization domain swap beta strand [polypeptide binding]; other site 507522004894 regulatory protein interface [polypeptide binding]; other site 507522004895 active site 507522004896 regulatory phosphorylation site [posttranslational modification]; other site 507522004897 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 507522004898 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 507522004899 dimer interface [polypeptide binding]; other site 507522004900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522004901 catalytic residue [active] 507522004902 putative sulfate transport protein CysZ; Validated; Region: PRK04949 507522004903 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 507522004904 cell division protein ZipA; Provisional; Region: PRK03427 507522004905 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 507522004906 FtsZ protein binding site [polypeptide binding]; other site 507522004907 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 507522004908 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 507522004909 nucleotide binding pocket [chemical binding]; other site 507522004910 K-X-D-G motif; other site 507522004911 catalytic site [active] 507522004912 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 507522004913 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 507522004914 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 507522004915 Dimer interface [polypeptide binding]; other site 507522004916 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 507522004917 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 507522004918 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 507522004919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522004920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004921 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 507522004922 putative dimerization interface [polypeptide binding]; other site 507522004923 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 507522004924 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 507522004925 active site 507522004926 HIGH motif; other site 507522004927 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 507522004928 active site 507522004929 KMSKS motif; other site 507522004930 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 507522004931 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 507522004932 MASE1; Region: MASE1; pfam05231 507522004933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522004934 metal binding site [ion binding]; metal-binding site 507522004935 active site 507522004936 I-site; other site 507522004937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522004938 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 507522004939 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 507522004940 Nucleoside recognition; Region: Gate; pfam07670 507522004941 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 507522004942 manganese transport protein MntH; Reviewed; Region: PRK00701 507522004943 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 507522004944 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522004945 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522004946 active site 507522004947 catalytic tetrad [active] 507522004948 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 507522004949 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 507522004950 dimer interface [polypeptide binding]; other site 507522004951 PYR/PP interface [polypeptide binding]; other site 507522004952 TPP binding site [chemical binding]; other site 507522004953 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522004954 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 507522004955 TPP-binding site [chemical binding]; other site 507522004956 dimer interface [polypeptide binding]; other site 507522004957 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 507522004958 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 507522004959 Cl- selectivity filter; other site 507522004960 Cl- binding residues [ion binding]; other site 507522004961 pore gating glutamate residue; other site 507522004962 dimer interface [polypeptide binding]; other site 507522004963 glucokinase; Provisional; Region: glk; PRK00292 507522004964 glucokinase, proteobacterial type; Region: glk; TIGR00749 507522004965 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 507522004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522004967 active site 507522004968 phosphorylation site [posttranslational modification] 507522004969 intermolecular recognition site; other site 507522004970 dimerization interface [polypeptide binding]; other site 507522004971 LytTr DNA-binding domain; Region: LytTR; pfam04397 507522004972 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 507522004973 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 507522004974 Histidine kinase; Region: His_kinase; pfam06580 507522004975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522004976 ATP binding site [chemical binding]; other site 507522004977 Mg2+ binding site [ion binding]; other site 507522004978 G-X-G motif; other site 507522004979 aminotransferase; Validated; Region: PRK08175 507522004980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522004981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522004982 homodimer interface [polypeptide binding]; other site 507522004983 catalytic residue [active] 507522004984 putative cyanate transporter; Provisional; Region: cynX; PRK09705 507522004985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522004986 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 507522004987 nucleoside/Zn binding site; other site 507522004988 dimer interface [polypeptide binding]; other site 507522004989 catalytic motif [active] 507522004990 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 507522004991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522004992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522004993 dimerization interface [polypeptide binding]; other site 507522004994 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 507522004995 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 507522004996 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 507522004997 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 507522004998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 507522004999 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 507522005000 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522005001 dimer interface [polypeptide binding]; other site 507522005002 active site 507522005003 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 507522005004 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 507522005005 substrate binding site [chemical binding]; other site 507522005006 oxyanion hole (OAH) forming residues; other site 507522005007 trimer interface [polypeptide binding]; other site 507522005008 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522005009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522005010 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522005011 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 507522005012 catalytic core [active] 507522005013 hypothetical protein; Provisional; Region: PRK04946 507522005014 Smr domain; Region: Smr; pfam01713 507522005015 HemK family putative methylases; Region: hemK_fam; TIGR00536 507522005016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522005017 S-adenosylmethionine binding site [chemical binding]; other site 507522005018 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 507522005019 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 507522005020 Tetramer interface [polypeptide binding]; other site 507522005021 active site 507522005022 FMN-binding site [chemical binding]; other site 507522005023 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 507522005024 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 507522005025 hypothetical protein; Provisional; Region: PRK10621 507522005026 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 507522005027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 507522005028 YfcL protein; Region: YfcL; pfam08891 507522005029 Uncharacterized conserved protein [Function unknown]; Region: COG4121 507522005030 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 507522005031 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 507522005032 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 507522005033 dimer interface [polypeptide binding]; other site 507522005034 active site 507522005035 putative transporter; Provisional; Region: PRK12382 507522005036 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522005037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522005038 DNA-binding site [nucleotide binding]; DNA binding site 507522005039 UTRA domain; Region: UTRA; pfam07702 507522005040 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522005041 active site 507522005042 P-loop; other site 507522005043 phosphorylation site [posttranslational modification] 507522005044 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522005045 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 507522005046 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 507522005047 active site 507522005048 methionine cluster; other site 507522005049 phosphorylation site [posttranslational modification] 507522005050 metal binding site [ion binding]; metal-binding site 507522005051 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 507522005052 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522005053 trimer interface; other site 507522005054 sugar binding site [chemical binding]; other site 507522005055 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 507522005056 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 507522005057 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 507522005058 ligand binding site [chemical binding]; other site 507522005059 NAD binding site [chemical binding]; other site 507522005060 catalytic site [active] 507522005061 homodimer interface [polypeptide binding]; other site 507522005062 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 507522005063 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 507522005064 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 507522005065 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 507522005066 dimerization interface 3.5A [polypeptide binding]; other site 507522005067 active site 507522005068 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522005069 hypothetical protein; Provisional; Region: PRK10847 507522005070 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 507522005071 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 507522005072 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 507522005073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522005074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522005075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 507522005076 Sporulation related domain; Region: SPOR; pfam05036 507522005077 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 507522005078 colicin V production protein; Provisional; Region: PRK10845 507522005079 amidophosphoribosyltransferase; Provisional; Region: PRK09246 507522005080 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 507522005081 active site 507522005082 tetramer interface [polypeptide binding]; other site 507522005083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522005084 active site 507522005085 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 507522005086 Flavoprotein; Region: Flavoprotein; pfam02441 507522005087 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 507522005088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522005089 substrate binding pocket [chemical binding]; other site 507522005090 membrane-bound complex binding site; other site 507522005091 hinge residues; other site 507522005092 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 507522005093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522005094 substrate binding pocket [chemical binding]; other site 507522005095 membrane-bound complex binding site; other site 507522005096 hinge residues; other site 507522005097 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522005098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005099 dimer interface [polypeptide binding]; other site 507522005100 conserved gate region; other site 507522005101 putative PBP binding loops; other site 507522005102 ABC-ATPase subunit interface; other site 507522005103 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522005104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005105 dimer interface [polypeptide binding]; other site 507522005106 conserved gate region; other site 507522005107 putative PBP binding loops; other site 507522005108 ABC-ATPase subunit interface; other site 507522005109 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 507522005110 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522005111 Walker A/P-loop; other site 507522005112 ATP binding site [chemical binding]; other site 507522005113 Q-loop/lid; other site 507522005114 ABC transporter signature motif; other site 507522005115 Walker B; other site 507522005116 D-loop; other site 507522005117 H-loop/switch region; other site 507522005118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522005119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522005120 Coenzyme A binding pocket [chemical binding]; other site 507522005121 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 507522005122 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 507522005123 putative NAD(P) binding site [chemical binding]; other site 507522005124 putative active site [active] 507522005125 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 507522005126 homooctamer interface [polypeptide binding]; other site 507522005127 active site 507522005128 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 507522005129 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 507522005130 C-terminal domain interface [polypeptide binding]; other site 507522005131 GSH binding site (G-site) [chemical binding]; other site 507522005132 dimer interface [polypeptide binding]; other site 507522005133 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 507522005134 N-terminal domain interface [polypeptide binding]; other site 507522005135 putative dimer interface [polypeptide binding]; other site 507522005136 active site 507522005137 glutathione S-transferase; Provisional; Region: PRK15113 507522005138 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 507522005139 C-terminal domain interface [polypeptide binding]; other site 507522005140 GSH binding site (G-site) [chemical binding]; other site 507522005141 dimer interface [polypeptide binding]; other site 507522005142 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 507522005143 N-terminal domain interface [polypeptide binding]; other site 507522005144 putative dimer interface [polypeptide binding]; other site 507522005145 putative substrate binding pocket (H-site) [chemical binding]; other site 507522005146 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 507522005147 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522005148 active site 507522005149 metal binding site [ion binding]; metal-binding site 507522005150 homotetramer interface [polypeptide binding]; other site 507522005151 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 507522005152 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 507522005153 nudix motif; other site 507522005154 phosphate acetyltransferase; Reviewed; Region: PRK05632 507522005155 DRTGG domain; Region: DRTGG; pfam07085 507522005156 phosphate acetyltransferase; Region: pta; TIGR00651 507522005157 propionate/acetate kinase; Provisional; Region: PRK12379 507522005158 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 507522005159 hypothetical protein; Provisional; Region: PRK01816 507522005160 hypothetical protein; Validated; Region: PRK05445 507522005161 putative phosphatase; Provisional; Region: PRK11587 507522005162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522005163 motif II; other site 507522005164 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 507522005165 transmembrane helices; other site 507522005166 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522005167 TrkA-C domain; Region: TrkA_C; pfam02080 507522005168 TrkA-C domain; Region: TrkA_C; pfam02080 507522005169 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 507522005170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522005171 Zn2+ binding site [ion binding]; other site 507522005172 Mg2+ binding site [ion binding]; other site 507522005173 aminotransferase AlaT; Validated; Region: PRK09265 507522005174 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522005175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522005176 homodimer interface [polypeptide binding]; other site 507522005177 catalytic residue [active] 507522005178 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 507522005179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005180 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 507522005181 putative dimerization interface [polypeptide binding]; other site 507522005182 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 507522005183 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 507522005184 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 507522005185 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 507522005186 NADH dehydrogenase subunit D; Validated; Region: PRK06075 507522005187 NADH dehydrogenase subunit E; Validated; Region: PRK07539 507522005188 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 507522005189 putative dimer interface [polypeptide binding]; other site 507522005190 [2Fe-2S] cluster binding site [ion binding]; other site 507522005191 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 507522005192 SLBB domain; Region: SLBB; pfam10531 507522005193 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 507522005194 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 507522005195 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522005196 catalytic loop [active] 507522005197 iron binding site [ion binding]; other site 507522005198 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 507522005199 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 507522005200 [4Fe-4S] binding site [ion binding]; other site 507522005201 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 507522005202 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 507522005203 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 507522005204 4Fe-4S binding domain; Region: Fer4; pfam00037 507522005205 4Fe-4S binding domain; Region: Fer4; pfam00037 507522005206 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 507522005207 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 507522005208 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 507522005209 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 507522005210 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 507522005211 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 507522005212 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 507522005213 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 507522005214 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 507522005215 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 507522005216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 507522005217 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 507522005218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522005219 Coenzyme A binding pocket [chemical binding]; other site 507522005220 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 507522005221 chorismate binding enzyme; Region: Chorismate_bind; cl10555 507522005222 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 507522005223 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 507522005224 dimer interface [polypeptide binding]; other site 507522005225 tetramer interface [polypeptide binding]; other site 507522005226 PYR/PP interface [polypeptide binding]; other site 507522005227 TPP binding site [chemical binding]; other site 507522005228 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 507522005229 TPP-binding site; other site 507522005230 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 507522005231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 507522005232 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 507522005233 substrate binding site [chemical binding]; other site 507522005234 oxyanion hole (OAH) forming residues; other site 507522005235 trimer interface [polypeptide binding]; other site 507522005236 O-succinylbenzoate synthase; Provisional; Region: PRK05105 507522005237 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 507522005238 active site 507522005239 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 507522005240 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 507522005241 acyl-activating enzyme (AAE) consensus motif; other site 507522005242 putative AMP binding site [chemical binding]; other site 507522005243 putative active site [active] 507522005244 putative CoA binding site [chemical binding]; other site 507522005245 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 507522005246 putative transposase; Provisional; Region: PRK09857 507522005247 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 507522005248 YfaZ precursor; Region: YfaZ; pfam07437 507522005249 Organic solvent tolerance protein; Region: OstA_C; pfam04453 507522005250 hypothetical protein; Provisional; Region: PRK03673 507522005251 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 507522005252 putative MPT binding site; other site 507522005253 Competence-damaged protein; Region: CinA; cl00666 507522005254 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522005255 Transcriptional regulator [Transcription]; Region: IclR; COG1414 507522005256 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522005257 L-rhamnonate dehydratase; Provisional; Region: PRK15440 507522005258 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 507522005259 putative active site pocket [active] 507522005260 putative metal binding site [ion binding]; other site 507522005261 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 507522005262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005263 putative substrate translocation pore; other site 507522005264 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 507522005265 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 507522005266 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522005267 Cysteine-rich domain; Region: CCG; pfam02754 507522005268 Cysteine-rich domain; Region: CCG; pfam02754 507522005269 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 507522005270 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 507522005271 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 507522005272 hydroxyglutarate oxidase; Provisional; Region: PRK11728 507522005273 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 507522005274 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 507522005275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005276 putative substrate translocation pore; other site 507522005277 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 507522005278 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 507522005279 active site 507522005280 catalytic site [active] 507522005281 metal binding site [ion binding]; metal-binding site 507522005282 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 507522005283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522005284 catalytic loop [active] 507522005285 iron binding site [ion binding]; other site 507522005286 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 507522005287 dimer interface [polypeptide binding]; other site 507522005288 putative radical transfer pathway; other site 507522005289 diiron center [ion binding]; other site 507522005290 tyrosyl radical; other site 507522005291 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 507522005292 ATP cone domain; Region: ATP-cone; pfam03477 507522005293 Class I ribonucleotide reductase; Region: RNR_I; cd01679 507522005294 active site 507522005295 dimer interface [polypeptide binding]; other site 507522005296 catalytic residues [active] 507522005297 effector binding site; other site 507522005298 R2 peptide binding site; other site 507522005299 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 507522005300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522005301 S-adenosylmethionine binding site [chemical binding]; other site 507522005302 DNA gyrase subunit A; Validated; Region: PRK05560 507522005303 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 507522005304 CAP-like domain; other site 507522005305 active site 507522005306 primary dimer interface [polypeptide binding]; other site 507522005307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005311 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 507522005313 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 507522005314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522005315 dimer interface [polypeptide binding]; other site 507522005316 phosphorylation site [posttranslational modification] 507522005317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522005318 ATP binding site [chemical binding]; other site 507522005319 Mg2+ binding site [ion binding]; other site 507522005320 G-X-G motif; other site 507522005321 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 507522005322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522005323 active site 507522005324 phosphorylation site [posttranslational modification] 507522005325 intermolecular recognition site; other site 507522005326 dimerization interface [polypeptide binding]; other site 507522005327 transcriptional regulator RcsB; Provisional; Region: PRK10840 507522005328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522005329 active site 507522005330 phosphorylation site [posttranslational modification] 507522005331 intermolecular recognition site; other site 507522005332 dimerization interface [polypeptide binding]; other site 507522005333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522005334 DNA binding residues [nucleotide binding] 507522005335 dimerization interface [polypeptide binding]; other site 507522005336 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 507522005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522005338 ATP binding site [chemical binding]; other site 507522005339 Mg2+ binding site [ion binding]; other site 507522005340 G-X-G motif; other site 507522005341 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 507522005342 putative binding surface; other site 507522005343 active site 507522005344 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522005345 outer membrane porin protein C; Provisional; Region: PRK10554 507522005346 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 507522005347 ApbE family; Region: ApbE; pfam02424 507522005348 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 507522005349 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 507522005350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522005351 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 507522005352 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 507522005353 DNA binding site [nucleotide binding] 507522005354 active site 507522005355 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 507522005356 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 507522005357 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 507522005358 Walker A/P-loop; other site 507522005359 ATP binding site [chemical binding]; other site 507522005360 Q-loop/lid; other site 507522005361 ABC transporter signature motif; other site 507522005362 Walker B; other site 507522005363 D-loop; other site 507522005364 H-loop/switch region; other site 507522005365 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 507522005366 MgtE intracellular N domain; Region: MgtE_N; smart00924 507522005367 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 507522005368 Divalent cation transporter; Region: MgtE; cl00786 507522005369 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 507522005370 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 507522005371 Sulfate transporter family; Region: Sulfate_transp; pfam00916 507522005372 malate:quinone oxidoreductase; Validated; Region: PRK05257 507522005373 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 507522005374 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 507522005375 secondary substrate binding site; other site 507522005376 primary substrate binding site; other site 507522005377 inhibition loop; other site 507522005378 dimerization interface [polypeptide binding]; other site 507522005379 Domain of unknown function DUF20; Region: UPF0118; pfam01594 507522005380 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 507522005381 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 507522005382 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522005383 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522005384 Walker A/P-loop; other site 507522005385 ATP binding site [chemical binding]; other site 507522005386 Q-loop/lid; other site 507522005387 ABC transporter signature motif; other site 507522005388 Walker B; other site 507522005389 D-loop; other site 507522005390 H-loop/switch region; other site 507522005391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005392 putative PBP binding loops; other site 507522005393 dimer interface [polypeptide binding]; other site 507522005394 ABC-ATPase subunit interface; other site 507522005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005396 dimer interface [polypeptide binding]; other site 507522005397 conserved gate region; other site 507522005398 putative PBP binding loops; other site 507522005399 ABC-ATPase subunit interface; other site 507522005400 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522005401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522005402 substrate binding pocket [chemical binding]; other site 507522005403 membrane-bound complex binding site; other site 507522005404 hinge residues; other site 507522005405 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 507522005406 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 507522005407 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 507522005408 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 507522005409 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 507522005410 Sulfatase; Region: Sulfatase; cl17466 507522005411 hypothetical protein; Provisional; Region: PRK13689 507522005412 Nucleoid-associated protein [General function prediction only]; Region: COG3081 507522005413 nucleoid-associated protein NdpA; Validated; Region: PRK00378 507522005414 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522005415 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522005416 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522005417 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 507522005418 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 507522005419 dimer interface [polypeptide binding]; other site 507522005420 ADP-ribose binding site [chemical binding]; other site 507522005421 active site 507522005422 nudix motif; other site 507522005423 metal binding site [ion binding]; metal-binding site 507522005424 Beta-lactamase; Region: Beta-lactamase; pfam00144 507522005425 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 507522005426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522005427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522005429 dimerization interface [polypeptide binding]; other site 507522005430 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 507522005431 5S rRNA interface [nucleotide binding]; other site 507522005432 CTC domain interface [polypeptide binding]; other site 507522005433 L16 interface [polypeptide binding]; other site 507522005434 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 507522005435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522005436 ATP binding site [chemical binding]; other site 507522005437 putative Mg++ binding site [ion binding]; other site 507522005438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522005439 nucleotide binding region [chemical binding]; other site 507522005440 ATP-binding site [chemical binding]; other site 507522005441 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 507522005442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522005443 RNA binding surface [nucleotide binding]; other site 507522005444 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 507522005445 active site 507522005446 uracil binding [chemical binding]; other site 507522005447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005448 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 507522005449 putative substrate translocation pore; other site 507522005450 hypothetical protein; Provisional; Region: PRK11835 507522005451 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 507522005452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522005453 Walker A/P-loop; other site 507522005454 ATP binding site [chemical binding]; other site 507522005455 Q-loop/lid; other site 507522005456 ABC transporter signature motif; other site 507522005457 Walker B; other site 507522005458 D-loop; other site 507522005459 H-loop/switch region; other site 507522005460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522005461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522005462 Walker A/P-loop; other site 507522005463 ATP binding site [chemical binding]; other site 507522005464 Q-loop/lid; other site 507522005465 ABC transporter signature motif; other site 507522005466 Walker B; other site 507522005467 D-loop; other site 507522005468 H-loop/switch region; other site 507522005469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522005470 microcin C ABC transporter permease; Provisional; Region: PRK15021 507522005471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005472 dimer interface [polypeptide binding]; other site 507522005473 conserved gate region; other site 507522005474 ABC-ATPase subunit interface; other site 507522005475 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 507522005476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005477 dimer interface [polypeptide binding]; other site 507522005478 conserved gate region; other site 507522005479 putative PBP binding loops; other site 507522005480 ABC-ATPase subunit interface; other site 507522005481 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 507522005482 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 507522005483 phage resistance protein; Provisional; Region: PRK10551 507522005484 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 507522005485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522005486 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 507522005487 NlpC/P60 family; Region: NLPC_P60; pfam00877 507522005488 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 507522005489 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 507522005490 active site 507522005491 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 507522005492 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 507522005493 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 507522005494 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 507522005495 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522005496 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522005497 mannonate dehydratase; Provisional; Region: PRK03906 507522005498 mannonate dehydratase; Region: uxuA; TIGR00695 507522005499 elongation factor P; Provisional; Region: PRK04542 507522005500 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 507522005501 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 507522005502 RNA binding site [nucleotide binding]; other site 507522005503 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 507522005504 RNA binding site [nucleotide binding]; other site 507522005505 Flagellin N-methylase; Region: FliB; cl00497 507522005506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522005507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005508 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522005509 putative effector binding pocket; other site 507522005510 dimerization interface [polypeptide binding]; other site 507522005511 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 507522005512 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 507522005513 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522005514 Occludin homology domain; Region: Occludin_ELL; pfam07303 507522005515 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522005516 sugar efflux transporter B; Provisional; Region: PRK15011 507522005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005518 putative substrate translocation pore; other site 507522005519 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 507522005520 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522005521 active site 507522005522 phosphorylation site [posttranslational modification] 507522005523 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 507522005524 dimerization domain swap beta strand [polypeptide binding]; other site 507522005525 regulatory protein interface [polypeptide binding]; other site 507522005526 active site 507522005527 regulatory phosphorylation site [posttranslational modification]; other site 507522005528 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 507522005529 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 507522005530 putative substrate binding site [chemical binding]; other site 507522005531 putative ATP binding site [chemical binding]; other site 507522005532 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 507522005533 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 507522005534 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 507522005535 active site 507522005536 P-loop; other site 507522005537 phosphorylation site [posttranslational modification] 507522005538 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 507522005539 endonuclease IV; Provisional; Region: PRK01060 507522005540 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 507522005541 DNA interaction; other site 507522005542 Metal-binding active site; metal-binding site 507522005543 AP (apurinic/apyrimidinic) site pocket; other site 507522005544 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 507522005545 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 507522005546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005547 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 507522005548 putative dimerization interface [polypeptide binding]; other site 507522005549 lysine transporter; Provisional; Region: PRK10836 507522005550 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 507522005551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522005552 N-terminal plug; other site 507522005553 ligand-binding site [chemical binding]; other site 507522005554 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 507522005555 S-formylglutathione hydrolase; Region: PLN02442 507522005556 GTP cyclohydrolase I; Provisional; Region: PLN03044 507522005557 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 507522005558 active site 507522005559 Predicted membrane protein [Function unknown]; Region: COG2311 507522005560 hypothetical protein; Provisional; Region: PRK10835 507522005561 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 507522005562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522005563 DNA binding site [nucleotide binding] 507522005564 domain linker motif; other site 507522005565 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 507522005566 dimerization interface (closed form) [polypeptide binding]; other site 507522005567 ligand binding site [chemical binding]; other site 507522005568 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 507522005569 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 507522005570 ligand binding site [chemical binding]; other site 507522005571 calcium binding site [ion binding]; other site 507522005572 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522005573 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 507522005574 Walker A/P-loop; other site 507522005575 ATP binding site [chemical binding]; other site 507522005576 Q-loop/lid; other site 507522005577 ABC transporter signature motif; other site 507522005578 Walker B; other site 507522005579 D-loop; other site 507522005580 H-loop/switch region; other site 507522005581 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522005582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522005583 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522005584 TM-ABC transporter signature motif; other site 507522005585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522005586 non-specific DNA binding site [nucleotide binding]; other site 507522005587 salt bridge; other site 507522005588 sequence-specific DNA binding site [nucleotide binding]; other site 507522005589 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 507522005590 putative active site [active] 507522005591 cytidine deaminase; Provisional; Region: PRK09027 507522005592 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 507522005593 active site 507522005594 catalytic motif [active] 507522005595 Zn binding site [ion binding]; other site 507522005596 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 507522005597 active site 507522005598 catalytic motif [active] 507522005599 Zn binding site [ion binding]; other site 507522005600 hypothetical protein; Provisional; Region: PRK10711 507522005601 hypothetical protein; Provisional; Region: PRK01821 507522005602 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 507522005603 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 507522005604 FMN binding site [chemical binding]; other site 507522005605 active site 507522005606 catalytic residues [active] 507522005607 substrate binding site [chemical binding]; other site 507522005608 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 507522005609 transcriptional antiterminator BglG; Provisional; Region: PRK09772 507522005610 CAT RNA binding domain; Region: CAT_RBD; smart01061 507522005611 PRD domain; Region: PRD; pfam00874 507522005612 PRD domain; Region: PRD; pfam00874 507522005613 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 507522005614 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522005615 active site turn [active] 507522005616 phosphorylation site [posttranslational modification] 507522005617 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522005618 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 507522005619 HPr interaction site; other site 507522005620 glycerol kinase (GK) interaction site [polypeptide binding]; other site 507522005621 active site 507522005622 phosphorylation site [posttranslational modification] 507522005623 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 507522005624 beta-galactosidase; Region: BGL; TIGR03356 507522005625 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522005626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522005627 S-adenosylmethionine binding site [chemical binding]; other site 507522005628 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 507522005629 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522005630 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522005631 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 507522005632 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 507522005633 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 507522005634 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 507522005635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522005636 Coenzyme A binding pocket [chemical binding]; other site 507522005637 D-lactate dehydrogenase; Provisional; Region: PRK11183 507522005638 FAD binding domain; Region: FAD_binding_4; pfam01565 507522005639 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 507522005640 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 507522005641 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 507522005642 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 507522005643 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 507522005644 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 507522005645 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 507522005646 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 507522005647 Walker A/P-loop; other site 507522005648 ATP binding site [chemical binding]; other site 507522005649 Q-loop/lid; other site 507522005650 ABC transporter signature motif; other site 507522005651 Walker B; other site 507522005652 D-loop; other site 507522005653 H-loop/switch region; other site 507522005654 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 507522005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005656 putative PBP binding loops; other site 507522005657 ABC-ATPase subunit interface; other site 507522005658 hypothetical protein; Provisional; Region: PRK13681 507522005659 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 507522005660 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 507522005661 GAF domain; Region: GAF; pfam01590 507522005662 Histidine kinase; Region: His_kinase; pfam06580 507522005663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522005664 ATP binding site [chemical binding]; other site 507522005665 Mg2+ binding site [ion binding]; other site 507522005666 G-X-G motif; other site 507522005667 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 507522005668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522005669 active site 507522005670 phosphorylation site [posttranslational modification] 507522005671 intermolecular recognition site; other site 507522005672 dimerization interface [polypeptide binding]; other site 507522005673 LytTr DNA-binding domain; Region: LytTR; pfam04397 507522005674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 507522005675 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 507522005676 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 507522005677 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 507522005678 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 507522005679 active site 507522005680 HIGH motif; other site 507522005681 KMSKS motif; other site 507522005682 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 507522005683 tRNA binding surface [nucleotide binding]; other site 507522005684 anticodon binding site; other site 507522005685 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 507522005686 dimer interface [polypeptide binding]; other site 507522005687 putative tRNA-binding site [nucleotide binding]; other site 507522005688 antiporter inner membrane protein; Provisional; Region: PRK11670 507522005689 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 507522005690 Walker A motif; other site 507522005691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522005692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522005693 Coenzyme A binding pocket [chemical binding]; other site 507522005694 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 507522005695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522005696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005697 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522005698 putative effector binding pocket; other site 507522005699 dimerization interface [polypeptide binding]; other site 507522005700 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 507522005701 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 507522005702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522005703 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 507522005704 active site 507522005705 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 507522005706 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 507522005707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522005709 dimerization interface [polypeptide binding]; other site 507522005710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522005711 Ligand Binding Site [chemical binding]; other site 507522005712 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 507522005713 substrate binding site [chemical binding]; other site 507522005714 multimerization interface [polypeptide binding]; other site 507522005715 ATP binding site [chemical binding]; other site 507522005716 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 507522005717 dimer interface [polypeptide binding]; other site 507522005718 substrate binding site [chemical binding]; other site 507522005719 ATP binding site [chemical binding]; other site 507522005720 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 507522005721 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 507522005722 putative active site; other site 507522005723 catalytic residue [active] 507522005724 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 507522005725 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 507522005726 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 507522005727 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522005728 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 507522005729 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522005730 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 507522005731 N- and C-terminal domain interface [polypeptide binding]; other site 507522005732 D-xylulose kinase; Region: XylB; TIGR01312 507522005733 active site 507522005734 MgATP binding site [chemical binding]; other site 507522005735 catalytic site [active] 507522005736 metal binding site [ion binding]; metal-binding site 507522005737 xylulose binding site [chemical binding]; other site 507522005738 homodimer interface [polypeptide binding]; other site 507522005739 polyol permease family; Region: 2A0118; TIGR00897 507522005740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005741 putative substrate translocation pore; other site 507522005742 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 507522005743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522005744 motif II; other site 507522005745 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 507522005746 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 507522005747 putative active site pocket [active] 507522005748 metal binding site [ion binding]; metal-binding site 507522005749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522005750 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 507522005751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522005752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005753 dimer interface [polypeptide binding]; other site 507522005754 conserved gate region; other site 507522005755 putative PBP binding loops; other site 507522005756 ABC-ATPase subunit interface; other site 507522005757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 507522005758 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522005759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522005760 dimer interface [polypeptide binding]; other site 507522005761 conserved gate region; other site 507522005762 ABC-ATPase subunit interface; other site 507522005763 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 507522005764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522005765 Walker A/P-loop; other site 507522005766 ATP binding site [chemical binding]; other site 507522005767 Q-loop/lid; other site 507522005768 ABC transporter signature motif; other site 507522005769 Walker B; other site 507522005770 D-loop; other site 507522005771 H-loop/switch region; other site 507522005772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522005773 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 507522005774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522005775 Walker A/P-loop; other site 507522005776 ATP binding site [chemical binding]; other site 507522005777 Q-loop/lid; other site 507522005778 ABC transporter signature motif; other site 507522005779 Walker B; other site 507522005780 D-loop; other site 507522005781 H-loop/switch region; other site 507522005782 lipid kinase; Reviewed; Region: PRK13054 507522005783 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 507522005784 putative protease; Provisional; Region: PRK15452 507522005785 Peptidase family U32; Region: Peptidase_U32; pfam01136 507522005786 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 507522005787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522005788 active site 507522005789 phosphorylation site [posttranslational modification] 507522005790 intermolecular recognition site; other site 507522005791 dimerization interface [polypeptide binding]; other site 507522005792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522005793 DNA binding site [nucleotide binding] 507522005794 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 507522005795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522005796 dimerization interface [polypeptide binding]; other site 507522005797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522005798 dimer interface [polypeptide binding]; other site 507522005799 phosphorylation site [posttranslational modification] 507522005800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522005801 ATP binding site [chemical binding]; other site 507522005802 Mg2+ binding site [ion binding]; other site 507522005803 G-X-G motif; other site 507522005804 putative transporter; Provisional; Region: PRK10504 507522005805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005806 putative substrate translocation pore; other site 507522005807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522005808 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 507522005809 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 507522005810 Protein export membrane protein; Region: SecD_SecF; cl14618 507522005811 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 507522005812 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522005813 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522005814 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 507522005815 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 507522005816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522005817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 507522005818 DNA binding residues [nucleotide binding] 507522005819 transcriptional regulator PhoB; Provisional; Region: PRK10161 507522005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522005821 active site 507522005822 phosphorylation site [posttranslational modification] 507522005823 intermolecular recognition site; other site 507522005824 dimerization interface [polypeptide binding]; other site 507522005825 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 507522005826 DNA binding site [nucleotide binding] 507522005827 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 507522005828 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 507522005829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 507522005830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522005831 dimer interface [polypeptide binding]; other site 507522005832 phosphorylation site [posttranslational modification] 507522005833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522005834 ATP binding site [chemical binding]; other site 507522005835 Mg2+ binding site [ion binding]; other site 507522005836 G-X-G motif; other site 507522005837 putative chaperone; Provisional; Region: PRK11678 507522005838 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 507522005839 nucleotide binding site [chemical binding]; other site 507522005840 putative NEF/HSP70 interaction site [polypeptide binding]; other site 507522005841 SBD interface [polypeptide binding]; other site 507522005842 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 507522005843 AlkA N-terminal domain; Region: AlkA_N; pfam06029 507522005844 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 507522005845 minor groove reading motif; other site 507522005846 helix-hairpin-helix signature motif; other site 507522005847 substrate binding pocket [chemical binding]; other site 507522005848 active site 507522005849 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 507522005850 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 507522005851 ATP-binding site [chemical binding]; other site 507522005852 Sugar specificity; other site 507522005853 Pyrimidine base specificity; other site 507522005854 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 507522005855 trimer interface [polypeptide binding]; other site 507522005856 active site 507522005857 putative assembly protein; Provisional; Region: PRK10833 507522005858 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 507522005859 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 507522005860 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 507522005861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 507522005862 Transporter associated domain; Region: CorC_HlyC; smart01091 507522005863 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 507522005864 active site 507522005865 tetramer interface; other site 507522005866 Acid phosphatase homologues; Region: acidPPc; smart00014 507522005867 active site 507522005868 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 507522005869 polysaccharide export protein Wza; Provisional; Region: PRK15078 507522005870 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 507522005871 SLBB domain; Region: SLBB; pfam10531 507522005872 SLBB domain; Region: SLBB; pfam10531 507522005873 tyrosine kinase; Provisional; Region: PRK11519 507522005874 Chain length determinant protein; Region: Wzz; pfam02706 507522005875 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 507522005876 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522005877 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 507522005878 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 507522005879 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 507522005880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005881 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 507522005882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 507522005884 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 507522005885 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 507522005886 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 507522005887 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 507522005888 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 507522005889 Acyltransferase family; Region: Acyl_transf_3; pfam01757 507522005890 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 507522005891 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 507522005892 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 507522005893 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 507522005894 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 507522005895 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 507522005896 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 507522005897 Substrate binding site; other site 507522005898 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 507522005899 phosphomannomutase CpsG; Provisional; Region: PRK15414 507522005900 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 507522005901 active site 507522005902 substrate binding site [chemical binding]; other site 507522005903 metal binding site [ion binding]; metal-binding site 507522005904 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 507522005905 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 507522005906 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 507522005907 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 507522005908 Acyltransferase family; Region: Acyl_transf_3; pfam01757 507522005909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 507522005910 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 507522005911 putative NAD(P) binding site [chemical binding]; other site 507522005912 active site 507522005913 putative substrate binding site [chemical binding]; other site 507522005914 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 507522005915 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 507522005916 Substrate binding site; other site 507522005917 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 507522005918 phosphomannomutase CpsG; Provisional; Region: PRK15414 507522005919 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 507522005920 active site 507522005921 substrate binding site [chemical binding]; other site 507522005922 metal binding site [ion binding]; metal-binding site 507522005923 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 507522005924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 507522005925 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 507522005926 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 507522005927 Walker A/P-loop; other site 507522005928 ATP binding site [chemical binding]; other site 507522005929 Q-loop/lid; other site 507522005930 ABC transporter signature motif; other site 507522005931 Walker B; other site 507522005932 D-loop; other site 507522005933 H-loop/switch region; other site 507522005934 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 507522005935 putative carbohydrate binding site [chemical binding]; other site 507522005936 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522005937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522005938 S-adenosylmethionine binding site [chemical binding]; other site 507522005939 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 507522005940 ATP binding site [chemical binding]; other site 507522005941 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 507522005942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005943 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 507522005944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005946 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 507522005947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 507522005948 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 507522005949 putative ADP-binding pocket [chemical binding]; other site 507522005950 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 507522005951 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 507522005952 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 507522005953 metal binding site [ion binding]; metal-binding site 507522005954 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 507522005955 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 507522005956 substrate binding site [chemical binding]; other site 507522005957 glutamase interaction surface [polypeptide binding]; other site 507522005958 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 507522005959 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 507522005960 catalytic residues [active] 507522005961 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 507522005962 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 507522005963 putative active site [active] 507522005964 oxyanion strand; other site 507522005965 catalytic triad [active] 507522005966 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 507522005967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522005968 active site 507522005969 motif I; other site 507522005970 motif II; other site 507522005971 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 507522005972 putative active site pocket [active] 507522005973 4-fold oligomerization interface [polypeptide binding]; other site 507522005974 metal binding residues [ion binding]; metal-binding site 507522005975 3-fold/trimer interface [polypeptide binding]; other site 507522005976 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 507522005977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522005978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522005979 homodimer interface [polypeptide binding]; other site 507522005980 catalytic residue [active] 507522005981 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 507522005982 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 507522005983 NAD binding site [chemical binding]; other site 507522005984 dimerization interface [polypeptide binding]; other site 507522005985 product binding site; other site 507522005986 substrate binding site [chemical binding]; other site 507522005987 zinc binding site [ion binding]; other site 507522005988 catalytic residues [active] 507522005989 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 507522005990 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 507522005991 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 507522005992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 507522005993 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 507522005994 putative NAD(P) binding site [chemical binding]; other site 507522005995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522005996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522005997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522005998 dimerization interface [polypeptide binding]; other site 507522005999 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 507522006000 NifQ; Region: NifQ; pfam04891 507522006001 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 507522006002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522006003 FeS/SAM binding site; other site 507522006004 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 507522006005 Nif-specific regulatory protein; Region: nifA; TIGR01817 507522006006 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 507522006007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522006008 Walker A motif; other site 507522006009 ATP binding site [chemical binding]; other site 507522006010 Walker B motif; other site 507522006011 arginine finger; other site 507522006012 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522006013 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 507522006014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522006015 putative active site [active] 507522006016 heme pocket [chemical binding]; other site 507522006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522006018 ATP binding site [chemical binding]; other site 507522006019 G-X-G motif; other site 507522006020 flavodoxin FldA; Validated; Region: PRK09267 507522006021 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 507522006022 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 507522006023 NifZ domain; Region: NifZ; pfam04319 507522006024 Nitrogen fixation protein NifW; Region: NifW; cl03935 507522006025 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 507522006026 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 507522006027 active site 507522006028 catalytic residues [active] 507522006029 metal binding site [ion binding]; metal-binding site 507522006030 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 507522006031 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 507522006032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522006033 catalytic residue [active] 507522006034 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 507522006035 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 507522006036 trimerization site [polypeptide binding]; other site 507522006037 active site 507522006038 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 507522006039 NifU-like domain; Region: NifU; pfam01106 507522006040 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 507522006041 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 507522006042 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 507522006043 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 507522006044 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 507522006045 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 507522006046 NifT/FixU protein; Region: NifT; pfam06988 507522006047 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 507522006048 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 507522006049 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 507522006050 MoFe protein beta/alpha subunit interactions; other site 507522006051 Beta subunit P cluster binding residues; other site 507522006052 MoFe protein beta subunit/Fe protein contacts; other site 507522006053 MoFe protein dimer/ dimer interactions; other site 507522006054 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 507522006055 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 507522006056 MoFe protein alpha/beta subunit interactions; other site 507522006057 Alpha subunit P cluster binding residues; other site 507522006058 FeMoco binding residues [chemical binding]; other site 507522006059 MoFe protein alpha subunit/Fe protein contacts; other site 507522006060 MoFe protein dimer/ dimer interactions; other site 507522006061 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 507522006062 nitrogenase iron protein; Region: nifH; TIGR01287 507522006063 Nucleotide-binding sites [chemical binding]; other site 507522006064 Walker A motif; other site 507522006065 Switch I region of nucleotide binding site; other site 507522006066 Fe4S4 binding sites [ion binding]; other site 507522006067 Switch II region of nucleotide binding site; other site 507522006068 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 507522006069 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 507522006070 dimer interface [polypeptide binding]; other site 507522006071 PYR/PP interface [polypeptide binding]; other site 507522006072 TPP binding site [chemical binding]; other site 507522006073 substrate binding site [chemical binding]; other site 507522006074 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 507522006075 Domain of unknown function; Region: EKR; pfam10371 507522006076 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522006077 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 507522006078 TPP-binding site [chemical binding]; other site 507522006079 dimer interface [polypeptide binding]; other site 507522006080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522006081 dimerization interface [polypeptide binding]; other site 507522006082 putative DNA binding site [nucleotide binding]; other site 507522006083 putative Zn2+ binding site [ion binding]; other site 507522006084 elongation factor G; Reviewed; Region: PRK00007 507522006085 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 507522006086 G1 box; other site 507522006087 putative GEF interaction site [polypeptide binding]; other site 507522006088 GTP/Mg2+ binding site [chemical binding]; other site 507522006089 Switch I region; other site 507522006090 G2 box; other site 507522006091 G3 box; other site 507522006092 Switch II region; other site 507522006093 G4 box; other site 507522006094 G5 box; other site 507522006095 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 507522006096 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 507522006097 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 507522006098 exonuclease I; Provisional; Region: sbcB; PRK11779 507522006099 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 507522006100 active site 507522006101 catalytic site [active] 507522006102 substrate binding site [chemical binding]; other site 507522006103 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 507522006104 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 507522006105 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 507522006106 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 507522006107 DNA gyrase inhibitor; Provisional; Region: PRK10016 507522006108 Predicted membrane protein [Function unknown]; Region: COG1289 507522006109 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522006110 hypothetical protein; Provisional; Region: PRK05423 507522006111 cobalamin synthase; Reviewed; Region: cobS; PRK00235 507522006112 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 507522006113 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 507522006114 putative dimer interface [polypeptide binding]; other site 507522006115 active site pocket [active] 507522006116 putative cataytic base [active] 507522006117 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 507522006118 NAD binding site [chemical binding]; other site 507522006119 HPP family; Region: HPP; pfam04982 507522006120 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 507522006121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006123 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522006124 putative effector binding pocket; other site 507522006125 dimerization interface [polypeptide binding]; other site 507522006126 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 507522006127 shikimate transporter; Provisional; Region: PRK09952 507522006128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006129 putative substrate translocation pore; other site 507522006130 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 507522006131 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522006132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522006133 metal binding site [ion binding]; metal-binding site 507522006134 active site 507522006135 I-site; other site 507522006136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522006137 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 507522006138 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 507522006139 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 507522006140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006141 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522006142 dimerization interface [polypeptide binding]; other site 507522006143 substrate binding pocket [chemical binding]; other site 507522006144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 507522006145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 507522006146 TAP-like protein; Region: Abhydrolase_4; pfam08386 507522006147 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 507522006148 GAF domain; Region: GAF; pfam01590 507522006149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522006150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522006151 metal binding site [ion binding]; metal-binding site 507522006152 active site 507522006153 I-site; other site 507522006154 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 507522006155 active site 507522006156 substrate binding site [chemical binding]; other site 507522006157 ATP binding site [chemical binding]; other site 507522006158 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 507522006159 PemK-like protein; Region: PemK; cl00995 507522006160 AMP nucleosidase; Provisional; Region: PRK08292 507522006161 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 507522006162 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 507522006163 signal transduction protein PmrD; Provisional; Region: PRK15450 507522006164 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 507522006165 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 507522006166 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 507522006167 NADP binding site [chemical binding]; other site 507522006168 dimer interface [polypeptide binding]; other site 507522006169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522006170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522006171 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 507522006172 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 507522006173 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 507522006174 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 507522006175 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 507522006176 dimer interface [polypeptide binding]; other site 507522006177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522006178 catalytic residue [active] 507522006179 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 507522006180 MPN+ (JAMM) motif; other site 507522006181 Zinc-binding site [ion binding]; other site 507522006182 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 507522006183 MoaE interaction surface [polypeptide binding]; other site 507522006184 MoeB interaction surface [polypeptide binding]; other site 507522006185 thiocarboxylated glycine; other site 507522006186 hypothetical protein; Validated; Region: PRK07411 507522006187 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 507522006188 ATP binding site [chemical binding]; other site 507522006189 substrate interface [chemical binding]; other site 507522006190 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 507522006191 active site residue [active] 507522006192 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 507522006193 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 507522006194 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 507522006195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522006196 catalytic residue [active] 507522006197 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 507522006198 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 507522006199 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 507522006200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522006201 ABC transporter signature motif; other site 507522006202 Walker B; other site 507522006203 D-loop; other site 507522006204 H-loop/switch region; other site 507522006205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522006206 ATP binding site [chemical binding]; other site 507522006207 putative Mg++ binding site [ion binding]; other site 507522006208 helicase superfamily c-terminal domain; Region: HELICc; smart00490 507522006209 nucleotide binding region [chemical binding]; other site 507522006210 ATP-binding site [chemical binding]; other site 507522006211 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 507522006212 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 507522006213 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 507522006214 GIY-YIG motif/motif A; other site 507522006215 active site 507522006216 catalytic site [active] 507522006217 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 507522006218 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 507522006219 NADP binding site [chemical binding]; other site 507522006220 dimer interface [polypeptide binding]; other site 507522006221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522006224 dimerization interface [polypeptide binding]; other site 507522006225 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 507522006226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522006227 active site 507522006228 DNA binding site [nucleotide binding] 507522006229 Int/Topo IB signature motif; other site 507522006230 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 507522006231 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522006232 active site 507522006233 DNA binding site [nucleotide binding] 507522006234 Int/Topo IB signature motif; other site 507522006235 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 507522006236 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 507522006237 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522006238 active site 507522006239 DNA binding site [nucleotide binding] 507522006240 Int/Topo IB signature motif; other site 507522006241 DNA methylase; Region: N6_N4_Mtase; cl17433 507522006242 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 507522006243 DNA methylase; Region: N6_N4_Mtase; cl17433 507522006244 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 507522006245 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 507522006246 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 507522006247 conjugal transfer protein TrbM; Provisional; Region: PRK13893 507522006248 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 507522006249 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 507522006250 Walker A motif; other site 507522006251 hexamer interface [polypeptide binding]; other site 507522006252 ATP binding site [chemical binding]; other site 507522006253 Walker B motif; other site 507522006254 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 507522006255 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 507522006256 VirB7 interaction site; other site 507522006257 VirB8 protein; Region: VirB8; pfam04335 507522006258 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 507522006259 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 507522006260 Type IV secretion system proteins; Region: T4SS; pfam07996 507522006261 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 507522006262 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 507522006263 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 507522006264 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 507522006265 TrbC/VIRB2 family; Region: TrbC; pfam04956 507522006266 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522006267 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522006268 catalytic residue [active] 507522006269 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 507522006270 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 507522006271 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 507522006272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006274 putative substrate translocation pore; other site 507522006275 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 507522006276 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 507522006277 FAD binding domain; Region: FAD_binding_4; pfam01565 507522006278 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 507522006279 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 507522006280 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 507522006281 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522006282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522006283 homodimer interface [polypeptide binding]; other site 507522006284 catalytic residue [active] 507522006285 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 507522006286 active sites [active] 507522006287 tetramer interface [polypeptide binding]; other site 507522006288 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 507522006289 active site 507522006290 iron coordination sites [ion binding]; other site 507522006291 integrase; Provisional; Region: PRK09692 507522006292 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522006293 active site 507522006294 Int/Topo IB signature motif; other site 507522006295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006297 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 507522006298 putative substrate binding pocket [chemical binding]; other site 507522006299 dimerization interface [polypeptide binding]; other site 507522006300 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 507522006301 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 507522006302 NAD(P) binding site [chemical binding]; other site 507522006303 catalytic residues [active] 507522006304 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 507522006305 choline dehydrogenase; Validated; Region: PRK02106 507522006306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 507522006307 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 507522006308 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 507522006309 Na binding site [ion binding]; other site 507522006310 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 507522006311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522006312 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 507522006313 homotrimer interaction site [polypeptide binding]; other site 507522006314 putative active site [active] 507522006315 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 507522006316 acetylornithine deacetylase; Provisional; Region: PRK07522 507522006317 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 507522006318 metal binding site [ion binding]; metal-binding site 507522006319 putative dimer interface [polypeptide binding]; other site 507522006320 Borna disease virus P40 protein; Region: BDV_P40; pfam06407 507522006321 integrase; Provisional; Region: PRK09692 507522006322 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522006323 active site 507522006324 Int/Topo IB signature motif; other site 507522006325 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 507522006326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006327 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 507522006328 putative dimerization interface [polypeptide binding]; other site 507522006329 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 507522006330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522006331 dimerization interface [polypeptide binding]; other site 507522006332 L,D-transpeptidase; Provisional; Region: PRK10190 507522006333 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522006334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006336 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522006337 putative effector binding pocket; other site 507522006338 putative dimerization interface [polypeptide binding]; other site 507522006339 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 507522006340 homotrimer interaction site [polypeptide binding]; other site 507522006341 putative active site [active] 507522006342 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522006343 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 507522006344 NAD(P) binding site [chemical binding]; other site 507522006345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522006346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522006347 substrate binding pocket [chemical binding]; other site 507522006348 membrane-bound complex binding site; other site 507522006349 hinge residues; other site 507522006350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522006351 dimer interface [polypeptide binding]; other site 507522006352 conserved gate region; other site 507522006353 putative PBP binding loops; other site 507522006354 ABC-ATPase subunit interface; other site 507522006355 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522006356 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522006357 Walker A/P-loop; other site 507522006358 ATP binding site [chemical binding]; other site 507522006359 Q-loop/lid; other site 507522006360 ABC transporter signature motif; other site 507522006361 Walker B; other site 507522006362 D-loop; other site 507522006363 H-loop/switch region; other site 507522006364 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 507522006365 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 507522006366 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522006367 metal binding site [ion binding]; metal-binding site 507522006368 dimer interface [polypeptide binding]; other site 507522006369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 507522006370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522006371 Coenzyme A binding pocket [chemical binding]; other site 507522006372 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 507522006373 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 507522006374 tetramer interface [polypeptide binding]; other site 507522006375 active site 507522006376 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 507522006377 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 507522006378 putative active site [active] 507522006379 metal binding site [ion binding]; metal-binding site 507522006380 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 507522006381 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 507522006382 active site 507522006383 non-prolyl cis peptide bond; other site 507522006384 aspartate aminotransferase; Provisional; Region: PRK06107 507522006385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522006386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522006387 homodimer interface [polypeptide binding]; other site 507522006388 catalytic residue [active] 507522006389 NIPSNAP; Region: NIPSNAP; pfam07978 507522006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522006392 putative substrate translocation pore; other site 507522006393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522006397 dimerization interface [polypeptide binding]; other site 507522006398 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 507522006399 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 507522006400 thioester reductase domain; Region: Thioester-redct; TIGR01746 507522006401 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 507522006402 putative NAD(P) binding site [chemical binding]; other site 507522006403 active site 507522006404 putative substrate binding site [chemical binding]; other site 507522006405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006406 putative substrate translocation pore; other site 507522006407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522006408 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 507522006409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522006410 dimer interface [polypeptide binding]; other site 507522006411 active site 507522006412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006414 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522006415 putative effector binding pocket; other site 507522006416 dimerization interface [polypeptide binding]; other site 507522006417 integrase; Provisional; Region: PRK09692 507522006418 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522006419 active site 507522006420 Int/Topo IB signature motif; other site 507522006421 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 507522006422 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522006423 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 507522006424 trimer interface [polypeptide binding]; other site 507522006425 eyelet of channel; other site 507522006426 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 507522006427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522006428 Zn2+ binding site [ion binding]; other site 507522006429 Mg2+ binding site [ion binding]; other site 507522006430 DNA cytosine methylase; Provisional; Region: PRK10458 507522006431 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 507522006432 cofactor binding site; other site 507522006433 DNA binding site [nucleotide binding] 507522006434 substrate interaction site [chemical binding]; other site 507522006435 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 507522006436 additional DNA contacts [nucleotide binding]; other site 507522006437 mismatch recognition site; other site 507522006438 active site 507522006439 zinc binding site [ion binding]; other site 507522006440 DNA intercalation site [nucleotide binding]; other site 507522006441 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 507522006442 EamA-like transporter family; Region: EamA; pfam00892 507522006443 hypothetical protein; Provisional; Region: PRK10062 507522006444 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 507522006445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522006446 metal binding site [ion binding]; metal-binding site 507522006447 active site 507522006448 I-site; other site 507522006449 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 507522006450 hypothetical protein; Provisional; Region: PRK10708 507522006451 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 507522006452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522006453 DNA binding residues [nucleotide binding] 507522006454 dimerization interface [polypeptide binding]; other site 507522006455 lipoprotein; Provisional; Region: PRK10397 507522006456 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 507522006457 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 507522006458 active site 507522006459 Na/Ca binding site [ion binding]; other site 507522006460 catalytic site [active] 507522006461 cystine transporter subunit; Provisional; Region: PRK11260 507522006462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522006463 substrate binding pocket [chemical binding]; other site 507522006464 membrane-bound complex binding site; other site 507522006465 hinge residues; other site 507522006466 D-cysteine desulfhydrase; Validated; Region: PRK03910 507522006467 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 507522006468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522006469 catalytic residue [active] 507522006470 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522006471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522006472 dimer interface [polypeptide binding]; other site 507522006473 conserved gate region; other site 507522006474 putative PBP binding loops; other site 507522006475 ABC-ATPase subunit interface; other site 507522006476 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 507522006477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522006478 Walker A/P-loop; other site 507522006479 ATP binding site [chemical binding]; other site 507522006480 Q-loop/lid; other site 507522006481 ABC transporter signature motif; other site 507522006482 Walker B; other site 507522006483 D-loop; other site 507522006484 H-loop/switch region; other site 507522006485 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 507522006486 Autoinducer binding domain; Region: Autoind_bind; pfam03472 507522006487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522006488 DNA binding residues [nucleotide binding] 507522006489 dimerization interface [polypeptide binding]; other site 507522006490 hypothetical protein; Provisional; Region: PRK10613 507522006491 response regulator; Provisional; Region: PRK09483 507522006492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522006493 active site 507522006494 phosphorylation site [posttranslational modification] 507522006495 intermolecular recognition site; other site 507522006496 dimerization interface [polypeptide binding]; other site 507522006497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522006498 DNA binding residues [nucleotide binding] 507522006499 dimerization interface [polypeptide binding]; other site 507522006500 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 507522006501 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 507522006502 GIY-YIG motif/motif A; other site 507522006503 active site 507522006504 catalytic site [active] 507522006505 putative DNA binding site [nucleotide binding]; other site 507522006506 metal binding site [ion binding]; metal-binding site 507522006507 UvrB/uvrC motif; Region: UVR; pfam02151 507522006508 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 507522006509 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 507522006510 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 507522006511 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 507522006512 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 507522006513 inhibitor site; inhibition site 507522006514 active site 507522006515 dimer interface [polypeptide binding]; other site 507522006516 catalytic residue [active] 507522006517 hypothetical protein; Provisional; Region: PRK10396 507522006518 yecA family protein; Region: ygfB_yecA; TIGR02292 507522006519 SEC-C motif; Region: SEC-C; pfam02810 507522006520 tyrosine transporter TyrP; Provisional; Region: PRK15132 507522006521 aromatic amino acid transport protein; Region: araaP; TIGR00837 507522006522 probable metal-binding protein; Region: matur_matur; TIGR03853 507522006523 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 507522006524 Ferritin-like domain; Region: Ferritin; pfam00210 507522006525 ferroxidase diiron center [ion binding]; other site 507522006526 hypothetical protein; Provisional; Region: PRK09273 507522006527 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 507522006528 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 507522006529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522006531 putative substrate translocation pore; other site 507522006532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006533 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 507522006534 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522006535 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 507522006536 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 507522006537 Ferritin-like domain; Region: Ferritin; pfam00210 507522006538 ferroxidase diiron center [ion binding]; other site 507522006539 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 507522006540 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 507522006541 ligand binding site [chemical binding]; other site 507522006542 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 507522006543 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522006544 Walker A/P-loop; other site 507522006545 ATP binding site [chemical binding]; other site 507522006546 Q-loop/lid; other site 507522006547 ABC transporter signature motif; other site 507522006548 Walker B; other site 507522006549 D-loop; other site 507522006550 H-loop/switch region; other site 507522006551 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522006552 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522006553 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522006554 TM-ABC transporter signature motif; other site 507522006555 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 507522006556 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 507522006557 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 507522006558 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 507522006559 active site 507522006560 homotetramer interface [polypeptide binding]; other site 507522006561 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522006562 Ligand Binding Site [chemical binding]; other site 507522006563 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522006564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006565 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 507522006566 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 507522006567 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 507522006568 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 507522006569 active site 507522006570 HIGH motif; other site 507522006571 KMSK motif region; other site 507522006572 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 507522006573 tRNA binding surface [nucleotide binding]; other site 507522006574 anticodon binding site; other site 507522006575 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 507522006576 putative metal binding site [ion binding]; other site 507522006577 copper homeostasis protein CutC; Provisional; Region: PRK11572 507522006578 Methyltransferase domain; Region: Methyltransf_23; pfam13489 507522006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522006580 S-adenosylmethionine binding site [chemical binding]; other site 507522006581 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522006582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522006583 S-adenosylmethionine binding site [chemical binding]; other site 507522006584 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 507522006585 hypothetical protein; Provisional; Region: PRK10302 507522006586 Isochorismatase family; Region: Isochorismatase; pfam00857 507522006587 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 507522006588 catalytic triad [active] 507522006589 conserved cis-peptide bond; other site 507522006590 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 507522006591 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 507522006592 dimer interface [polypeptide binding]; other site 507522006593 anticodon binding site; other site 507522006594 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 507522006595 homodimer interface [polypeptide binding]; other site 507522006596 motif 1; other site 507522006597 active site 507522006598 motif 2; other site 507522006599 GAD domain; Region: GAD; pfam02938 507522006600 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 507522006601 active site 507522006602 motif 3; other site 507522006603 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 507522006604 nudix motif; other site 507522006605 hypothetical protein; Validated; Region: PRK00110 507522006606 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 507522006607 active site 507522006608 putative DNA-binding cleft [nucleotide binding]; other site 507522006609 dimer interface [polypeptide binding]; other site 507522006610 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 507522006611 RuvA N terminal domain; Region: RuvA_N; pfam01330 507522006612 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 507522006613 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 507522006614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522006615 Walker A motif; other site 507522006616 ATP binding site [chemical binding]; other site 507522006617 Walker B motif; other site 507522006618 arginine finger; other site 507522006619 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 507522006620 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 507522006621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522006622 ABC-ATPase subunit interface; other site 507522006623 dimer interface [polypeptide binding]; other site 507522006624 putative PBP binding regions; other site 507522006625 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 507522006626 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 507522006627 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 507522006628 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 507522006629 metal binding site [ion binding]; metal-binding site 507522006630 putative peptidase; Provisional; Region: PRK11649 507522006631 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 507522006632 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522006633 Peptidase family M23; Region: Peptidase_M23; pfam01551 507522006634 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 507522006635 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 507522006636 putative acyl-acceptor binding pocket; other site 507522006637 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 507522006638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522006639 active site 507522006640 phosphorylation site [posttranslational modification] 507522006641 intermolecular recognition site; other site 507522006642 dimerization interface [polypeptide binding]; other site 507522006643 malate dehydrogenase; Provisional; Region: PRK13529 507522006644 Malic enzyme, N-terminal domain; Region: malic; pfam00390 507522006645 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 507522006646 NAD(P) binding site [chemical binding]; other site 507522006647 Predicted permeases [General function prediction only]; Region: COG0679 507522006648 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 507522006649 pyruvate kinase; Provisional; Region: PRK05826 507522006650 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 507522006651 domain interfaces; other site 507522006652 active site 507522006653 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 507522006654 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522006655 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522006656 putative active site [active] 507522006657 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 507522006658 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 507522006659 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 507522006660 phosphogluconate dehydratase; Validated; Region: PRK09054 507522006661 6-phosphogluconate dehydratase; Region: edd; TIGR01196 507522006662 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 507522006663 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 507522006664 active site 507522006665 intersubunit interface [polypeptide binding]; other site 507522006666 catalytic residue [active] 507522006667 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 507522006668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 507522006669 ATP-grasp domain; Region: ATP-grasp; pfam02222 507522006670 YebG protein; Region: YebG; pfam07130 507522006671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 507522006672 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 507522006673 putative metal binding site [ion binding]; other site 507522006674 protease 2; Provisional; Region: PRK10115 507522006675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522006676 exodeoxyribonuclease X; Provisional; Region: PRK07983 507522006677 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 507522006678 active site 507522006679 catalytic site [active] 507522006680 substrate binding site [chemical binding]; other site 507522006681 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 507522006682 CopC domain; Region: CopC; cl01012 507522006683 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 507522006684 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 507522006685 Protein of unknown function (DUF535); Region: DUF535; pfam04393 507522006686 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 507522006687 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522006688 active site 507522006689 metal binding site [ion binding]; metal-binding site 507522006690 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 507522006691 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 507522006692 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 507522006693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522006694 S-adenosylmethionine binding site [chemical binding]; other site 507522006695 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 507522006696 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 507522006697 mce related protein; Region: MCE; pfam02470 507522006698 mce related protein; Region: MCE; pfam02470 507522006699 mce related protein; Region: MCE; pfam02470 507522006700 mce related protein; Region: MCE; pfam02470 507522006701 mce related protein; Region: MCE; pfam02470 507522006702 mce related protein; Region: MCE; pfam02470 507522006703 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 507522006704 Paraquat-inducible protein A; Region: PqiA; pfam04403 507522006705 Paraquat-inducible protein A; Region: PqiA; pfam04403 507522006706 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 507522006707 GAF domain; Region: GAF_2; pfam13185 507522006708 ProP expression regulator; Provisional; Region: PRK04950 507522006709 ProQ/FINO family; Region: ProQ; pfam04352 507522006710 carboxy-terminal protease; Provisional; Region: PRK11186 507522006711 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 507522006712 protein binding site [polypeptide binding]; other site 507522006713 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 507522006714 Catalytic dyad [active] 507522006715 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 507522006716 heat shock protein HtpX; Provisional; Region: PRK05457 507522006717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522006719 putative substrate translocation pore; other site 507522006720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006721 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 507522006722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522006723 dimerization interface [polypeptide binding]; other site 507522006724 putative Zn2+ binding site [ion binding]; other site 507522006725 putative DNA binding site [nucleotide binding]; other site 507522006726 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522006727 YobH-like protein; Region: YobH; pfam13996 507522006728 PhoPQ regulatory protein; Provisional; Region: PRK10299 507522006729 YebO-like protein; Region: YebO; pfam13974 507522006730 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522006731 DNA-binding site [nucleotide binding]; DNA binding site 507522006732 RNA-binding motif; other site 507522006733 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 507522006734 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 507522006735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 507522006736 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 507522006737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522006738 S-adenosylmethionine binding site [chemical binding]; other site 507522006739 hypothetical protein; Provisional; Region: PRK11469 507522006740 Domain of unknown function DUF; Region: DUF204; pfam02659 507522006741 Domain of unknown function DUF; Region: DUF204; pfam02659 507522006742 hypothetical protein; Provisional; Region: PRK02913 507522006743 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 507522006744 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 507522006745 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 507522006746 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 507522006747 active pocket/dimerization site; other site 507522006748 active site 507522006749 phosphorylation site [posttranslational modification] 507522006750 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 507522006751 active site 507522006752 phosphorylation site [posttranslational modification] 507522006753 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 507522006754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 507522006755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 507522006756 Transporter associated domain; Region: CorC_HlyC; smart01091 507522006757 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 507522006758 phage resistance protein; Provisional; Region: PRK10551 507522006759 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522006760 L-serine deaminase; Provisional; Region: PRK15023 507522006761 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 507522006762 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 507522006763 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 507522006764 putative active site [active] 507522006765 putative CoA binding site [chemical binding]; other site 507522006766 nudix motif; other site 507522006767 metal binding site [ion binding]; metal-binding site 507522006768 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 507522006769 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 507522006770 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 507522006771 hypothetical protein; Provisional; Region: PRK05114 507522006772 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 507522006773 homotrimer interaction site [polypeptide binding]; other site 507522006774 putative active site [active] 507522006775 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 507522006776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 507522006777 DEAD_2; Region: DEAD_2; pfam06733 507522006778 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 507522006779 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 507522006780 Glycoprotease family; Region: Peptidase_M22; pfam00814 507522006781 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 507522006782 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 507522006783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 507522006784 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 507522006785 acyl-activating enzyme (AAE) consensus motif; other site 507522006786 putative AMP binding site [chemical binding]; other site 507522006787 putative active site [active] 507522006788 putative CoA binding site [chemical binding]; other site 507522006789 ribonuclease D; Provisional; Region: PRK10829 507522006790 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 507522006791 catalytic site [active] 507522006792 putative active site [active] 507522006793 putative substrate binding site [chemical binding]; other site 507522006794 Helicase and RNase D C-terminal; Region: HRDC; smart00341 507522006795 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 507522006796 cell division inhibitor MinD; Provisional; Region: PRK10818 507522006797 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 507522006798 Switch I; other site 507522006799 Switch II; other site 507522006800 septum formation inhibitor; Reviewed; Region: minC; PRK03511 507522006801 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 507522006802 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 507522006803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 507522006804 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 507522006805 hypothetical protein; Provisional; Region: PRK10691 507522006806 hypothetical protein; Provisional; Region: PRK05170 507522006807 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 507522006808 disulfide bond formation protein B; Provisional; Region: PRK01749 507522006809 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 507522006810 transmembrane helices; other site 507522006811 fatty acid metabolism regulator; Provisional; Region: PRK04984 507522006812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522006813 DNA-binding site [nucleotide binding]; DNA binding site 507522006814 FadR C-terminal domain; Region: FadR_C; pfam07840 507522006815 SpoVR family protein; Provisional; Region: PRK11767 507522006816 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 507522006817 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 507522006818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 507522006819 hydroxyglutarate oxidase; Provisional; Region: PRK11728 507522006820 alanine racemase; Reviewed; Region: dadX; PRK03646 507522006821 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 507522006822 active site 507522006823 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 507522006824 substrate binding site [chemical binding]; other site 507522006825 catalytic residues [active] 507522006826 dimer interface [polypeptide binding]; other site 507522006827 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 507522006828 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 507522006829 TrkA-C domain; Region: TrkA_C; pfam02080 507522006830 Transporter associated domain; Region: CorC_HlyC; smart01091 507522006831 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 507522006832 dimer interface [polypeptide binding]; other site 507522006833 catalytic triad [active] 507522006834 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 507522006835 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522006836 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522006837 catalytic residue [active] 507522006838 TIGR04222 domain; Region: near_uncomplex 507522006839 TIGR04222 domain; Region: near_uncomplex 507522006840 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 507522006841 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522006842 N-terminal plug; other site 507522006843 ligand-binding site [chemical binding]; other site 507522006844 trehalase; Provisional; Region: treA; PRK13271 507522006845 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 507522006846 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 507522006847 Uncharacterized conserved protein [Function unknown]; Region: COG2308 507522006848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 507522006849 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 507522006850 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 507522006851 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 507522006852 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 507522006853 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 507522006854 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 507522006855 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 507522006856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522006857 Walker A/P-loop; other site 507522006858 ATP binding site [chemical binding]; other site 507522006859 Q-loop/lid; other site 507522006860 ABC transporter signature motif; other site 507522006861 Walker B; other site 507522006862 D-loop; other site 507522006863 H-loop/switch region; other site 507522006864 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522006865 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 507522006866 ATP binding site [chemical binding]; other site 507522006867 substrate binding site [chemical binding]; other site 507522006868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522006869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522006870 dimer interface [polypeptide binding]; other site 507522006871 conserved gate region; other site 507522006872 putative PBP binding loops; other site 507522006873 ABC-ATPase subunit interface; other site 507522006874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522006875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522006876 dimer interface [polypeptide binding]; other site 507522006877 conserved gate region; other site 507522006878 putative PBP binding loops; other site 507522006879 ABC-ATPase subunit interface; other site 507522006880 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 507522006881 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 507522006882 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 507522006883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522006884 nucleotide binding site [chemical binding]; other site 507522006885 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 507522006886 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 507522006887 putative di-iron ligands [ion binding]; other site 507522006888 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 507522006889 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 507522006890 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 507522006891 active site 507522006892 non-prolyl cis peptide bond; other site 507522006893 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 507522006894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522006895 dimer interface [polypeptide binding]; other site 507522006896 conserved gate region; other site 507522006897 ABC-ATPase subunit interface; other site 507522006898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522006899 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 507522006900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522006901 Walker A/P-loop; other site 507522006902 ATP binding site [chemical binding]; other site 507522006903 Q-loop/lid; other site 507522006904 ABC transporter signature motif; other site 507522006905 Walker B; other site 507522006906 D-loop; other site 507522006907 H-loop/switch region; other site 507522006908 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 507522006909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522006911 dimerization interface [polypeptide binding]; other site 507522006912 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 507522006913 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 507522006914 tetramer interface [polypeptide binding]; other site 507522006915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522006916 catalytic residue [active] 507522006917 threonine/serine transporter TdcC; Provisional; Region: PRK13629 507522006918 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 507522006919 propionate/acetate kinase; Provisional; Region: PRK12379 507522006920 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 507522006921 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 507522006922 Pyruvate formate lyase 1; Region: PFL1; cd01678 507522006923 coenzyme A binding site [chemical binding]; other site 507522006924 active site 507522006925 catalytic residues [active] 507522006926 glycine loop; other site 507522006927 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 507522006928 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 507522006929 dimerization interface [polypeptide binding]; other site 507522006930 ligand binding site [chemical binding]; other site 507522006931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522006932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 507522006933 TM-ABC transporter signature motif; other site 507522006934 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 507522006935 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 507522006936 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 507522006937 TM-ABC transporter signature motif; other site 507522006938 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 507522006939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 507522006940 Walker A/P-loop; other site 507522006941 ATP binding site [chemical binding]; other site 507522006942 Q-loop/lid; other site 507522006943 ABC transporter signature motif; other site 507522006944 Walker B; other site 507522006945 D-loop; other site 507522006946 H-loop/switch region; other site 507522006947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 507522006948 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 507522006949 Walker A/P-loop; other site 507522006950 ATP binding site [chemical binding]; other site 507522006951 Q-loop/lid; other site 507522006952 ABC transporter signature motif; other site 507522006953 Walker B; other site 507522006954 D-loop; other site 507522006955 H-loop/switch region; other site 507522006956 cell density-dependent motility repressor; Provisional; Region: PRK10082 507522006957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522006959 dimerization interface [polypeptide binding]; other site 507522006960 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 507522006961 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 507522006962 active site 507522006963 substrate-binding site [chemical binding]; other site 507522006964 metal-binding site [ion binding] 507522006965 ATP binding site [chemical binding]; other site 507522006966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522006967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522006968 Coenzyme A binding pocket [chemical binding]; other site 507522006969 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 507522006970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522006972 dimerization interface [polypeptide binding]; other site 507522006973 citrate-proton symporter; Provisional; Region: PRK15075 507522006974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522006975 putative substrate translocation pore; other site 507522006976 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 507522006977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 507522006978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522006979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522006980 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 507522006981 putative dimerization interface [polypeptide binding]; other site 507522006982 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522006983 DNA-binding site [nucleotide binding]; DNA binding site 507522006984 RNA-binding motif; other site 507522006985 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 507522006986 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 507522006987 active site 507522006988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 507522006989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522006990 DNA-binding site [nucleotide binding]; DNA binding site 507522006991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 507522006992 FCD domain; Region: FCD; pfam07729 507522006993 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 507522006994 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 507522006995 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 507522006996 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 507522006997 active site 507522006998 intersubunit interface [polypeptide binding]; other site 507522006999 catalytic residue [active] 507522007000 galactonate dehydratase; Provisional; Region: PRK14017 507522007001 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 507522007002 putative active site pocket [active] 507522007003 putative metal binding site [ion binding]; other site 507522007004 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 507522007005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007006 putative substrate translocation pore; other site 507522007007 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 507522007008 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 507522007009 putative ligand binding site [chemical binding]; other site 507522007010 NAD binding site [chemical binding]; other site 507522007011 catalytic site [active] 507522007012 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 507522007013 putative active site pocket [active] 507522007014 dimerization interface [polypeptide binding]; other site 507522007015 putative catalytic residue [active] 507522007016 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 507522007017 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 507522007018 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 507522007019 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 507522007020 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522007021 ligand binding site [chemical binding]; other site 507522007022 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 507522007023 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 507522007024 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 507522007025 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 507522007026 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 507522007027 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 507522007028 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522007029 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522007030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522007031 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 507522007032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522007033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522007034 catalytic residue [active] 507522007035 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 507522007036 Peptidase family M23; Region: Peptidase_M23; pfam01551 507522007037 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 507522007038 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 507522007039 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 507522007040 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 507522007041 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 507522007042 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 507522007043 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 507522007044 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 507522007045 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 507522007046 ImpA domain protein; Region: DUF3702; pfam12486 507522007047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522007048 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 507522007049 putative ligand binding site [chemical binding]; other site 507522007050 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 507522007051 GTP-binding protein YchF; Reviewed; Region: PRK09601 507522007052 YchF GTPase; Region: YchF; cd01900 507522007053 G1 box; other site 507522007054 GTP/Mg2+ binding site [chemical binding]; other site 507522007055 Switch I region; other site 507522007056 G2 box; other site 507522007057 Switch II region; other site 507522007058 G3 box; other site 507522007059 G4 box; other site 507522007060 G5 box; other site 507522007061 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 507522007062 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 507522007063 putative active site [active] 507522007064 catalytic residue [active] 507522007065 hypothetical protein; Provisional; Region: PRK10692 507522007066 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 507522007067 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 507522007068 DNA binding residues [nucleotide binding] 507522007069 putative dimer interface [polypeptide binding]; other site 507522007070 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 507522007071 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 507522007072 putative transporter; Provisional; Region: PRK11660 507522007073 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 507522007074 Sulfate transporter family; Region: Sulfate_transp; pfam00916 507522007075 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 507522007076 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 507522007077 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 507522007078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522007079 active site 507522007080 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 507522007081 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 507522007082 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 507522007083 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 507522007084 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 507522007085 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 507522007086 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 507522007087 tRNA; other site 507522007088 putative tRNA binding site [nucleotide binding]; other site 507522007089 putative NADP binding site [chemical binding]; other site 507522007090 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 507522007091 peptide chain release factor 1; Validated; Region: prfA; PRK00591 507522007092 This domain is found in peptide chain release factors; Region: PCRF; smart00937 507522007093 RF-1 domain; Region: RF-1; pfam00472 507522007094 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 507522007095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522007096 hypothetical protein; Provisional; Region: PRK10278 507522007097 hypothetical protein; Provisional; Region: PRK10941 507522007098 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 507522007099 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 507522007100 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 507522007101 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 507522007102 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 507522007103 cation transport regulator; Reviewed; Region: chaB; PRK09582 507522007104 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 507522007105 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 507522007106 putative active site pocket [active] 507522007107 dimerization interface [polypeptide binding]; other site 507522007108 putative catalytic residue [active] 507522007109 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 507522007110 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 507522007111 Nitrate and nitrite sensing; Region: NIT; pfam08376 507522007112 ANTAR domain; Region: ANTAR; pfam03861 507522007113 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 507522007114 NMT1-like family; Region: NMT1_2; pfam13379 507522007115 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522007116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007117 dimer interface [polypeptide binding]; other site 507522007118 conserved gate region; other site 507522007119 putative PBP binding loops; other site 507522007120 ABC-ATPase subunit interface; other site 507522007121 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522007122 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522007123 Walker A/P-loop; other site 507522007124 ATP binding site [chemical binding]; other site 507522007125 Q-loop/lid; other site 507522007126 ABC transporter signature motif; other site 507522007127 Walker B; other site 507522007128 D-loop; other site 507522007129 H-loop/switch region; other site 507522007130 nitrite reductase subunit NirD; Provisional; Region: PRK14989 507522007131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522007132 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 507522007133 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522007134 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 507522007135 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 507522007136 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 507522007137 [4Fe-4S] binding site [ion binding]; other site 507522007138 molybdopterin cofactor binding site; other site 507522007139 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 507522007140 molybdopterin cofactor binding site; other site 507522007141 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 507522007142 putative invasin; Provisional; Region: PRK10177 507522007143 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 507522007144 transcriptional regulator NarL; Provisional; Region: PRK10651 507522007145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522007146 active site 507522007147 phosphorylation site [posttranslational modification] 507522007148 intermolecular recognition site; other site 507522007149 dimerization interface [polypeptide binding]; other site 507522007150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522007151 DNA binding residues [nucleotide binding] 507522007152 dimerization interface [polypeptide binding]; other site 507522007153 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 507522007154 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 507522007155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522007156 dimerization interface [polypeptide binding]; other site 507522007157 Histidine kinase; Region: HisKA_3; pfam07730 507522007158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522007159 ATP binding site [chemical binding]; other site 507522007160 Mg2+ binding site [ion binding]; other site 507522007161 G-X-G motif; other site 507522007162 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 507522007163 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 507522007164 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 507522007165 [4Fe-4S] binding site [ion binding]; other site 507522007166 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522007167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522007168 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522007169 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 507522007170 molybdopterin cofactor binding site; other site 507522007171 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 507522007172 4Fe-4S binding domain; Region: Fer4; cl02805 507522007173 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 507522007174 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 507522007175 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522007176 EamA-like transporter family; Region: EamA; pfam00892 507522007177 EamA-like transporter family; Region: EamA; pfam00892 507522007178 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 507522007179 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 507522007180 AsnC family; Region: AsnC_trans_reg; pfam01037 507522007181 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 507522007182 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 507522007183 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 507522007184 putative active site [active] 507522007185 putative substrate binding site [chemical binding]; other site 507522007186 putative cosubstrate binding site; other site 507522007187 catalytic site [active] 507522007188 SEC-C motif; Region: SEC-C; pfam02810 507522007189 hypothetical protein; Provisional; Region: PRK04233 507522007190 hypothetical protein; Provisional; Region: PRK10279 507522007191 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 507522007192 nucleophile elbow; other site 507522007193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522007194 active site 507522007195 response regulator of RpoS; Provisional; Region: PRK10693 507522007196 phosphorylation site [posttranslational modification] 507522007197 intermolecular recognition site; other site 507522007198 dimerization interface [polypeptide binding]; other site 507522007199 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 507522007200 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 507522007201 active site 507522007202 tetramer interface; other site 507522007203 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 507522007204 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 507522007205 thymidine kinase; Provisional; Region: PRK04296 507522007206 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 507522007207 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 507522007208 putative catalytic cysteine [active] 507522007209 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 507522007210 putative active site [active] 507522007211 metal binding site [ion binding]; metal-binding site 507522007212 hypothetical protein; Provisional; Region: PRK11111 507522007213 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 507522007214 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 507522007215 peptide binding site [polypeptide binding]; other site 507522007216 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 507522007217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007218 dimer interface [polypeptide binding]; other site 507522007219 conserved gate region; other site 507522007220 putative PBP binding loops; other site 507522007221 ABC-ATPase subunit interface; other site 507522007222 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 507522007223 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007225 dimer interface [polypeptide binding]; other site 507522007226 conserved gate region; other site 507522007227 ABC-ATPase subunit interface; other site 507522007228 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 507522007229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522007230 Walker A/P-loop; other site 507522007231 ATP binding site [chemical binding]; other site 507522007232 Q-loop/lid; other site 507522007233 ABC transporter signature motif; other site 507522007234 Walker B; other site 507522007235 D-loop; other site 507522007236 H-loop/switch region; other site 507522007237 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522007238 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 507522007239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522007240 Walker A/P-loop; other site 507522007241 ATP binding site [chemical binding]; other site 507522007242 Q-loop/lid; other site 507522007243 ABC transporter signature motif; other site 507522007244 Walker B; other site 507522007245 D-loop; other site 507522007246 H-loop/switch region; other site 507522007247 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522007248 Ion transport protein; Region: Ion_trans; pfam00520 507522007249 Ion channel; Region: Ion_trans_2; pfam07885 507522007250 dsDNA-mimic protein; Reviewed; Region: PRK05094 507522007251 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 507522007252 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 507522007253 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 507522007254 putative active site [active] 507522007255 catalytic site [active] 507522007256 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 507522007257 putative active site [active] 507522007258 catalytic site [active] 507522007259 Uncharacterized conserved protein [Function unknown]; Region: COG2353 507522007260 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 507522007261 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 507522007262 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 507522007263 Trp docking motif [polypeptide binding]; other site 507522007264 putative active site [active] 507522007265 YciI-like protein; Reviewed; Region: PRK11370 507522007266 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 507522007267 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522007268 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 507522007269 catalytic residues [active] 507522007270 catalytic nucleophile [active] 507522007271 Bacterial PH domain; Region: DUF304; pfam03703 507522007272 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522007273 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 507522007274 catalytic residues [active] 507522007275 catalytic nucleophile [active] 507522007276 Recombinase; Region: Recombinase; pfam07508 507522007277 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 507522007278 transport protein TonB; Provisional; Region: PRK10819 507522007279 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 507522007280 Phosphotransferase enzyme family; Region: APH; pfam01636 507522007281 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 507522007282 active site 507522007283 ATP binding site [chemical binding]; other site 507522007284 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 507522007285 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 507522007286 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 507522007287 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 507522007288 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 507522007289 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 507522007290 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 507522007291 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 507522007292 active site 507522007293 dimer interface [polypeptide binding]; other site 507522007294 motif 1; other site 507522007295 motif 2; other site 507522007296 motif 3; other site 507522007297 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 507522007298 anticodon binding site; other site 507522007299 translation initiation factor IF-3; Region: infC; TIGR00168 507522007300 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 507522007301 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 507522007302 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 507522007303 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 507522007304 23S rRNA binding site [nucleotide binding]; other site 507522007305 L21 binding site [polypeptide binding]; other site 507522007306 L13 binding site [polypeptide binding]; other site 507522007307 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 507522007308 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 507522007309 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 507522007310 dimer interface [polypeptide binding]; other site 507522007311 motif 1; other site 507522007312 active site 507522007313 motif 2; other site 507522007314 motif 3; other site 507522007315 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 507522007316 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 507522007317 putative tRNA-binding site [nucleotide binding]; other site 507522007318 B3/4 domain; Region: B3_4; pfam03483 507522007319 tRNA synthetase B5 domain; Region: B5; smart00874 507522007320 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 507522007321 dimer interface [polypeptide binding]; other site 507522007322 motif 1; other site 507522007323 motif 3; other site 507522007324 motif 2; other site 507522007325 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 507522007326 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 507522007327 IHF dimer interface [polypeptide binding]; other site 507522007328 IHF - DNA interface [nucleotide binding]; other site 507522007329 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 507522007330 homotrimer interaction site [polypeptide binding]; other site 507522007331 putative active site [active] 507522007332 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 507522007333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522007334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522007337 dimerization interface [polypeptide binding]; other site 507522007338 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522007339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522007340 ABC-ATPase subunit interface; other site 507522007341 dimer interface [polypeptide binding]; other site 507522007342 putative PBP binding regions; other site 507522007343 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 507522007344 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 507522007345 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 507522007346 catalytic residues [active] 507522007347 dimer interface [polypeptide binding]; other site 507522007348 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 507522007349 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522007350 Walker A/P-loop; other site 507522007351 ATP binding site [chemical binding]; other site 507522007352 Q-loop/lid; other site 507522007353 ABC transporter signature motif; other site 507522007354 Walker B; other site 507522007355 D-loop; other site 507522007356 H-loop/switch region; other site 507522007357 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 507522007358 NlpC/P60 family; Region: NLPC_P60; pfam00877 507522007359 Uncharacterized conserved protein [Function unknown]; Region: COG0397 507522007360 hypothetical protein; Validated; Region: PRK00029 507522007361 hypothetical protein; Provisional; Region: PRK10183 507522007362 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 507522007363 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 507522007364 PEP synthetase regulatory protein; Provisional; Region: PRK05339 507522007365 phosphoenolpyruvate synthase; Validated; Region: PRK06464 507522007366 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 507522007367 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 507522007368 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 507522007369 putative inner membrane protein; Provisional; Region: PRK10983 507522007370 Domain of unknown function DUF20; Region: UPF0118; pfam01594 507522007371 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 507522007372 FAD binding domain; Region: FAD_binding_4; pfam01565 507522007373 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 507522007374 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 507522007375 CoenzymeA binding site [chemical binding]; other site 507522007376 subunit interaction site [polypeptide binding]; other site 507522007377 PHB binding site; other site 507522007378 hypothetical protein; Provisional; Region: PRK10457 507522007379 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 507522007380 methionine synthase; Provisional; Region: PRK01207 507522007381 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 507522007382 substrate binding site [chemical binding]; other site 507522007383 THF binding site; other site 507522007384 zinc-binding site [ion binding]; other site 507522007385 multidrug resistance protein MdtH; Provisional; Region: PRK11646 507522007386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 507522007388 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522007389 Walker A/P-loop; other site 507522007390 ATP binding site [chemical binding]; other site 507522007391 Q-loop/lid; other site 507522007392 ABC transporter signature motif; other site 507522007393 Walker B; other site 507522007394 D-loop; other site 507522007395 H-loop/switch region; other site 507522007396 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522007397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522007398 ABC-ATPase subunit interface; other site 507522007399 dimer interface [polypeptide binding]; other site 507522007400 putative PBP binding regions; other site 507522007401 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 507522007402 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 507522007403 intersubunit interface [polypeptide binding]; other site 507522007404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522007407 dimerization interface [polypeptide binding]; other site 507522007408 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 507522007409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522007410 NAD(P) binding site [chemical binding]; other site 507522007411 active site 507522007412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522007413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522007414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522007415 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522007416 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522007417 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 507522007418 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 507522007419 phosphate binding site [ion binding]; other site 507522007420 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 507522007421 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 507522007422 putative ABC transporter; Region: ycf24; CHL00085 507522007423 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 507522007424 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 507522007425 Walker A/P-loop; other site 507522007426 ATP binding site [chemical binding]; other site 507522007427 Q-loop/lid; other site 507522007428 ABC transporter signature motif; other site 507522007429 Walker B; other site 507522007430 D-loop; other site 507522007431 H-loop/switch region; other site 507522007432 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 507522007433 FeS assembly protein SufD; Region: sufD; TIGR01981 507522007434 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 507522007435 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 507522007436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522007437 catalytic residue [active] 507522007438 cysteine desufuration protein SufE; Provisional; Region: PRK09296 507522007439 L,D-transpeptidase; Provisional; Region: PRK10190 507522007440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522007441 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522007442 murein lipoprotein; Provisional; Region: PRK15396 507522007443 pyruvate kinase; Provisional; Region: PRK09206 507522007444 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 507522007445 domain interfaces; other site 507522007446 active site 507522007447 hypothetical protein; Provisional; Region: PRK10292 507522007448 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 507522007449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522007450 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 507522007451 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 507522007452 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 507522007453 active site 507522007454 Fe binding site [ion binding]; other site 507522007455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007456 D-galactonate transporter; Region: 2A0114; TIGR00893 507522007457 putative substrate translocation pore; other site 507522007458 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 507522007459 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 507522007460 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 507522007461 shikimate binding site; other site 507522007462 NAD(P) binding site [chemical binding]; other site 507522007463 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 507522007464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 507522007465 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 507522007466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522007467 Walker A/P-loop; other site 507522007468 ATP binding site [chemical binding]; other site 507522007469 Q-loop/lid; other site 507522007470 ABC transporter signature motif; other site 507522007471 Walker B; other site 507522007472 D-loop; other site 507522007473 H-loop/switch region; other site 507522007474 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 507522007475 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522007476 ABC-ATPase subunit interface; other site 507522007477 dimer interface [polypeptide binding]; other site 507522007478 putative PBP binding regions; other site 507522007479 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 507522007480 putative ligand binding residues [chemical binding]; other site 507522007481 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 507522007482 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 507522007483 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522007484 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522007485 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 507522007486 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 507522007487 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 507522007488 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 507522007489 putative active site [active] 507522007490 Fe(II) binding site [ion binding]; other site 507522007491 putative dimer interface [polypeptide binding]; other site 507522007492 putative tetramer interface [polypeptide binding]; other site 507522007493 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 507522007494 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 507522007495 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 507522007496 acetaldehyde dehydrogenase; Validated; Region: PRK08300 507522007497 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 507522007498 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 507522007499 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 507522007500 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 507522007501 active site 507522007502 catalytic residues [active] 507522007503 metal binding site [ion binding]; metal-binding site 507522007504 DmpG-like communication domain; Region: DmpG_comm; pfam07836 507522007505 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 507522007506 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 507522007507 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 507522007508 active site residue [active] 507522007509 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 507522007510 active site residue [active] 507522007511 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 507522007512 active site residue [active] 507522007513 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 507522007514 active site residue [active] 507522007515 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 507522007516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522007519 dimerization interface [polypeptide binding]; other site 507522007520 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 507522007521 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 507522007522 dimer interface [polypeptide binding]; other site 507522007523 active site 507522007524 non-prolyl cis peptide bond; other site 507522007525 insertion regions; other site 507522007526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 507522007527 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 507522007528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522007529 membrane-bound complex binding site; other site 507522007530 hinge residues; other site 507522007531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 507522007532 NMT1/THI5 like; Region: NMT1; pfam09084 507522007533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522007534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007535 dimer interface [polypeptide binding]; other site 507522007536 conserved gate region; other site 507522007537 putative PBP binding loops; other site 507522007538 ABC-ATPase subunit interface; other site 507522007539 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522007540 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522007541 Walker A/P-loop; other site 507522007542 ATP binding site [chemical binding]; other site 507522007543 Q-loop/lid; other site 507522007544 ABC transporter signature motif; other site 507522007545 Walker B; other site 507522007546 D-loop; other site 507522007547 H-loop/switch region; other site 507522007548 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 507522007549 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522007550 N-terminal plug; other site 507522007551 ligand-binding site [chemical binding]; other site 507522007552 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 507522007553 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522007554 Walker A/P-loop; other site 507522007555 ATP binding site [chemical binding]; other site 507522007556 Q-loop/lid; other site 507522007557 ABC transporter signature motif; other site 507522007558 Walker B; other site 507522007559 D-loop; other site 507522007560 H-loop/switch region; other site 507522007561 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522007562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522007563 ABC-ATPase subunit interface; other site 507522007564 dimer interface [polypeptide binding]; other site 507522007565 putative PBP binding regions; other site 507522007566 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522007567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522007568 ABC-ATPase subunit interface; other site 507522007569 dimer interface [polypeptide binding]; other site 507522007570 putative PBP binding regions; other site 507522007571 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 507522007572 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 507522007573 siderophore binding site; other site 507522007574 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522007575 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522007576 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 507522007577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522007578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522007579 substrate binding pocket [chemical binding]; other site 507522007580 membrane-bound complex binding site; other site 507522007581 hinge residues; other site 507522007582 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522007583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007584 dimer interface [polypeptide binding]; other site 507522007585 conserved gate region; other site 507522007586 putative PBP binding loops; other site 507522007587 ABC-ATPase subunit interface; other site 507522007588 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522007589 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522007590 Walker A/P-loop; other site 507522007591 ATP binding site [chemical binding]; other site 507522007592 Q-loop/lid; other site 507522007593 ABC transporter signature motif; other site 507522007594 Walker B; other site 507522007595 D-loop; other site 507522007596 H-loop/switch region; other site 507522007597 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 507522007598 homotrimer interaction site [polypeptide binding]; other site 507522007599 putative active site [active] 507522007600 H+ Antiporter protein; Region: 2A0121; TIGR00900 507522007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007602 putative substrate translocation pore; other site 507522007603 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 507522007604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522007605 NAD(P) binding site [chemical binding]; other site 507522007606 active site 507522007607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522007610 dimerization interface [polypeptide binding]; other site 507522007611 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 507522007612 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 507522007613 putative heme binding pocket [chemical binding]; other site 507522007614 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 507522007615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522007616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522007617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 507522007618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522007619 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 507522007620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522007621 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522007622 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 507522007623 metal binding site [ion binding]; metal-binding site 507522007624 putative dimer interface [polypeptide binding]; other site 507522007625 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 507522007626 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 507522007627 [4Fe-4S] binding site [ion binding]; other site 507522007628 molybdopterin cofactor binding site; other site 507522007629 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 507522007630 molybdopterin cofactor binding site; other site 507522007631 putative dehydrogenase; Provisional; Region: PRK10098 507522007632 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 507522007633 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 507522007634 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 507522007635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007636 dimer interface [polypeptide binding]; other site 507522007637 conserved gate region; other site 507522007638 ABC-ATPase subunit interface; other site 507522007639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007640 dimer interface [polypeptide binding]; other site 507522007641 conserved gate region; other site 507522007642 putative PBP binding loops; other site 507522007643 ABC-ATPase subunit interface; other site 507522007644 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 507522007645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522007646 Walker A/P-loop; other site 507522007647 ATP binding site [chemical binding]; other site 507522007648 Q-loop/lid; other site 507522007649 ABC transporter signature motif; other site 507522007650 Walker B; other site 507522007651 D-loop; other site 507522007652 H-loop/switch region; other site 507522007653 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 507522007654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522007655 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 507522007656 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 507522007657 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 507522007658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 507522007659 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 507522007660 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 507522007661 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 507522007662 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 507522007663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522007664 Walker A/P-loop; other site 507522007665 ATP binding site [chemical binding]; other site 507522007666 Q-loop/lid; other site 507522007667 ABC transporter signature motif; other site 507522007668 Walker B; other site 507522007669 D-loop; other site 507522007670 H-loop/switch region; other site 507522007671 heme exporter protein CcmB; Region: ccmB; TIGR01190 507522007672 heme exporter protein CcmC; Region: ccmC; TIGR01191 507522007673 Heme exporter protein D (CcmD); Region: CcmD; cl11475 507522007674 CcmE; Region: CcmE; cl00994 507522007675 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 507522007676 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 507522007677 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 507522007678 catalytic residues [active] 507522007679 central insert; other site 507522007680 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 507522007681 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 507522007682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522007683 Coenzyme A binding pocket [chemical binding]; other site 507522007684 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 507522007685 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522007686 NADP binding site [chemical binding]; other site 507522007687 dimer interface [polypeptide binding]; other site 507522007688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522007691 dimerization interface [polypeptide binding]; other site 507522007692 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 507522007693 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 507522007694 active site 507522007695 dimer interface [polypeptide binding]; other site 507522007696 non-prolyl cis peptide bond; other site 507522007697 insertion regions; other site 507522007698 acetoin reductase; Validated; Region: PRK08643 507522007699 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 507522007700 NAD binding site [chemical binding]; other site 507522007701 homotetramer interface [polypeptide binding]; other site 507522007702 homodimer interface [polypeptide binding]; other site 507522007703 active site 507522007704 substrate binding site [chemical binding]; other site 507522007705 acetolactate synthase; Reviewed; Region: PRK08617 507522007706 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522007707 PYR/PP interface [polypeptide binding]; other site 507522007708 dimer interface [polypeptide binding]; other site 507522007709 TPP binding site [chemical binding]; other site 507522007710 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522007711 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 507522007712 TPP-binding site [chemical binding]; other site 507522007713 dimer interface [polypeptide binding]; other site 507522007714 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 507522007715 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 507522007716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007717 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 507522007718 putative dimerization interface [polypeptide binding]; other site 507522007719 putative substrate binding pocket [chemical binding]; other site 507522007720 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 507522007721 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 507522007722 NAD binding site [chemical binding]; other site 507522007723 homotetramer interface [polypeptide binding]; other site 507522007724 homodimer interface [polypeptide binding]; other site 507522007725 substrate binding site [chemical binding]; other site 507522007726 active site 507522007727 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 507522007728 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 507522007729 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522007730 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522007731 putative acyltransferase; Provisional; Region: PRK05790 507522007732 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522007733 dimer interface [polypeptide binding]; other site 507522007734 active site 507522007735 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 507522007736 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 507522007737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007739 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 507522007740 putative dimerization interface [polypeptide binding]; other site 507522007741 Protein of unknown function (DUF535); Region: DUF535; cl01128 507522007742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007743 putative substrate translocation pore; other site 507522007744 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522007745 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522007746 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 507522007747 active site 1 [active] 507522007748 dimer interface [polypeptide binding]; other site 507522007749 hexamer interface [polypeptide binding]; other site 507522007750 active site 2 [active] 507522007751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522007753 putative substrate translocation pore; other site 507522007754 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 507522007755 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 507522007756 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 507522007757 Chromate transporter; Region: Chromate_transp; pfam02417 507522007758 TIGR02594 family protein; Region: TIGR02594 507522007759 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 507522007760 FAD binding domain; Region: FAD_binding_4; pfam01565 507522007761 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522007762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007763 dimer interface [polypeptide binding]; other site 507522007764 conserved gate region; other site 507522007765 putative PBP binding loops; other site 507522007766 ABC-ATPase subunit interface; other site 507522007767 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522007768 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522007769 Walker A/P-loop; other site 507522007770 ATP binding site [chemical binding]; other site 507522007771 Q-loop/lid; other site 507522007772 ABC transporter signature motif; other site 507522007773 Walker B; other site 507522007774 D-loop; other site 507522007775 H-loop/switch region; other site 507522007776 NMT1/THI5 like; Region: NMT1; pfam09084 507522007777 Creatinine amidohydrolase; Region: Creatininase; pfam02633 507522007778 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 507522007779 homotrimer interaction site [polypeptide binding]; other site 507522007780 putative active site [active] 507522007781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522007782 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 507522007783 active site 507522007784 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 507522007785 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 507522007786 FMN-binding pocket [chemical binding]; other site 507522007787 flavin binding motif; other site 507522007788 phosphate binding motif [ion binding]; other site 507522007789 beta-alpha-beta structure motif; other site 507522007790 NAD binding pocket [chemical binding]; other site 507522007791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522007792 catalytic loop [active] 507522007793 iron binding site [ion binding]; other site 507522007794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522007797 dimerization interface [polypeptide binding]; other site 507522007798 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 507522007799 amidohydrolase; Provisional; Region: PRK12393 507522007800 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 507522007801 active site 507522007802 putative substrate binding pocket [chemical binding]; other site 507522007803 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 507522007804 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 507522007805 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 507522007806 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522007807 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522007808 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522007809 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 507522007810 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522007811 inhibitor-cofactor binding pocket; inhibition site 507522007812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522007813 catalytic residue [active] 507522007814 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 507522007815 active site 507522007816 substrate binding site [chemical binding]; other site 507522007817 Phosphotransferase enzyme family; Region: APH; pfam01636 507522007818 ATP binding site [chemical binding]; other site 507522007819 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 507522007820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522007821 NAD(P) binding site [chemical binding]; other site 507522007822 active site 507522007823 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 507522007824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007826 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 507522007827 putative effector binding pocket; other site 507522007828 putative dimerization interface [polypeptide binding]; other site 507522007829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522007831 putative substrate translocation pore; other site 507522007832 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 507522007833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522007834 dimerization interface [polypeptide binding]; other site 507522007835 DNA binding residues [nucleotide binding] 507522007836 DinB family; Region: DinB; cl17821 507522007837 DinB superfamily; Region: DinB_2; pfam12867 507522007838 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 507522007839 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 507522007840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522007841 Walker A/P-loop; other site 507522007842 ATP binding site [chemical binding]; other site 507522007843 Q-loop/lid; other site 507522007844 ABC transporter signature motif; other site 507522007845 Walker B; other site 507522007846 D-loop; other site 507522007847 H-loop/switch region; other site 507522007848 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522007849 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 507522007850 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522007851 Walker A/P-loop; other site 507522007852 ATP binding site [chemical binding]; other site 507522007853 Q-loop/lid; other site 507522007854 ABC transporter signature motif; other site 507522007855 Walker B; other site 507522007856 D-loop; other site 507522007857 H-loop/switch region; other site 507522007858 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522007859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 507522007860 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522007861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007862 dimer interface [polypeptide binding]; other site 507522007863 conserved gate region; other site 507522007864 putative PBP binding loops; other site 507522007865 ABC-ATPase subunit interface; other site 507522007866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522007867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007868 dimer interface [polypeptide binding]; other site 507522007869 conserved gate region; other site 507522007870 putative PBP binding loops; other site 507522007871 ABC-ATPase subunit interface; other site 507522007872 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522007873 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 507522007874 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 507522007875 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 507522007876 Walker A/P-loop; other site 507522007877 ATP binding site [chemical binding]; other site 507522007878 Q-loop/lid; other site 507522007879 ABC transporter signature motif; other site 507522007880 Walker B; other site 507522007881 D-loop; other site 507522007882 H-loop/switch region; other site 507522007883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522007884 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 507522007885 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 507522007886 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 507522007887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522007888 dimer interface [polypeptide binding]; other site 507522007889 conserved gate region; other site 507522007890 putative PBP binding loops; other site 507522007891 ABC-ATPase subunit interface; other site 507522007892 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 507522007893 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 507522007894 active site 507522007895 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 507522007896 Chloramphenicol acetyltransferase; Region: CAT; cl02008 507522007897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 507522007898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522007899 putative metal binding site [ion binding]; other site 507522007900 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522007901 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522007902 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522007903 LysE type translocator; Region: LysE; cl00565 507522007904 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 507522007905 active site clefts [active] 507522007906 zinc binding site [ion binding]; other site 507522007907 dimer interface [polypeptide binding]; other site 507522007908 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 507522007909 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522007910 putative NAD(P) binding site [chemical binding]; other site 507522007911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 507522007912 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 507522007913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522007914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522007916 dimerization interface [polypeptide binding]; other site 507522007917 Cupin; Region: Cupin_6; pfam12852 507522007918 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522007919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522007920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522007921 short chain dehydrogenase; Provisional; Region: PRK06180 507522007922 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 507522007923 NADP binding site [chemical binding]; other site 507522007924 active site 507522007925 steroid binding site; other site 507522007926 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 507522007927 multidrug efflux protein; Reviewed; Region: PRK01766 507522007928 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 507522007929 cation binding site [ion binding]; other site 507522007930 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 507522007931 Lumazine binding domain; Region: Lum_binding; pfam00677 507522007932 Lumazine binding domain; Region: Lum_binding; pfam00677 507522007933 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 507522007934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522007935 S-adenosylmethionine binding site [chemical binding]; other site 507522007936 putative transporter; Provisional; Region: PRK11043 507522007937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007938 putative substrate translocation pore; other site 507522007939 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 507522007940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522007941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522007942 dimerization interface [polypeptide binding]; other site 507522007943 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 507522007944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522007945 DNA binding site [nucleotide binding] 507522007946 domain linker motif; other site 507522007947 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 507522007948 dimerization interface [polypeptide binding]; other site 507522007949 ligand binding site [chemical binding]; other site 507522007950 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522007951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522007952 putative substrate translocation pore; other site 507522007953 superoxide dismutase; Provisional; Region: PRK10543 507522007954 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 507522007955 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 507522007956 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 507522007957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522007958 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 507522007959 NlpC/P60 family; Region: NLPC_P60; pfam00877 507522007960 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 507522007961 putative GSH binding site [chemical binding]; other site 507522007962 catalytic residues [active] 507522007963 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 507522007964 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 507522007965 dimer interface [polypeptide binding]; other site 507522007966 catalytic site [active] 507522007967 putative active site [active] 507522007968 putative substrate binding site [chemical binding]; other site 507522007969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522007970 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 507522007971 dimer interface [polypeptide binding]; other site 507522007972 active site 507522007973 metal binding site [ion binding]; metal-binding site 507522007974 glutathione binding site [chemical binding]; other site 507522007975 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522007976 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 507522007977 FMN binding site [chemical binding]; other site 507522007978 active site 507522007979 substrate binding site [chemical binding]; other site 507522007980 catalytic residue [active] 507522007981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522007982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522007983 Predicted Fe-S protein [General function prediction only]; Region: COG3313 507522007984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522007985 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522007986 active site 507522007987 catalytic tetrad [active] 507522007988 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 507522007989 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 507522007990 E-class dimer interface [polypeptide binding]; other site 507522007991 P-class dimer interface [polypeptide binding]; other site 507522007992 active site 507522007993 Cu2+ binding site [ion binding]; other site 507522007994 Zn2+ binding site [ion binding]; other site 507522007995 Fusaric acid resistance protein family; Region: FUSC; pfam04632 507522007996 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522007997 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 507522007998 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522007999 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522008000 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 507522008001 transcriptional regulator SlyA; Provisional; Region: PRK03573 507522008002 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 507522008003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522008004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522008005 metal binding site [ion binding]; metal-binding site 507522008006 active site 507522008007 I-site; other site 507522008008 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 507522008009 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 507522008010 lysozyme inhibitor; Provisional; Region: PRK11372 507522008011 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 507522008012 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 507522008013 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 507522008014 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 507522008015 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 507522008016 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 507522008017 active site 507522008018 HIGH motif; other site 507522008019 dimer interface [polypeptide binding]; other site 507522008020 KMSKS motif; other site 507522008021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522008022 RNA binding surface [nucleotide binding]; other site 507522008023 pyridoxamine kinase; Validated; Region: PRK05756 507522008024 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 507522008025 dimer interface [polypeptide binding]; other site 507522008026 pyridoxal binding site [chemical binding]; other site 507522008027 ATP binding site [chemical binding]; other site 507522008028 glutathionine S-transferase; Provisional; Region: PRK10542 507522008029 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 507522008030 C-terminal domain interface [polypeptide binding]; other site 507522008031 GSH binding site (G-site) [chemical binding]; other site 507522008032 dimer interface [polypeptide binding]; other site 507522008033 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 507522008034 N-terminal domain interface [polypeptide binding]; other site 507522008035 dimer interface [polypeptide binding]; other site 507522008036 substrate binding pocket (H-site) [chemical binding]; other site 507522008037 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 507522008038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008039 putative substrate translocation pore; other site 507522008040 POT family; Region: PTR2; pfam00854 507522008041 endonuclease III; Provisional; Region: PRK10702 507522008042 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 507522008043 minor groove reading motif; other site 507522008044 helix-hairpin-helix signature motif; other site 507522008045 substrate binding pocket [chemical binding]; other site 507522008046 active site 507522008047 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 507522008048 electron transport complex RsxE subunit; Provisional; Region: PRK12405 507522008049 electron transport complex protein RnfG; Validated; Region: PRK01908 507522008050 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 507522008051 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 507522008052 SLBB domain; Region: SLBB; pfam10531 507522008053 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522008054 electron transport complex protein RnfB; Provisional; Region: PRK05113 507522008055 Putative Fe-S cluster; Region: FeS; pfam04060 507522008056 4Fe-4S binding domain; Region: Fer4; cl02805 507522008057 electron transport complex protein RsxA; Provisional; Region: PRK05151 507522008058 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 507522008059 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 507522008060 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 507522008061 beta-galactosidase; Region: BGL; TIGR03356 507522008062 putative oxidoreductase; Provisional; Region: PRK11579 507522008063 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522008064 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522008065 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 507522008066 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 507522008067 active site 507522008068 purine riboside binding site [chemical binding]; other site 507522008069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008070 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522008071 putative substrate translocation pore; other site 507522008072 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522008073 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522008074 cytochrome b561; Provisional; Region: PRK11513 507522008075 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 507522008076 putative metal binding site [ion binding]; other site 507522008077 putative homodimer interface [polypeptide binding]; other site 507522008078 putative homotetramer interface [polypeptide binding]; other site 507522008079 putative homodimer-homodimer interface [polypeptide binding]; other site 507522008080 putative allosteric switch controlling residues; other site 507522008081 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 507522008082 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 507522008083 substrate binding site [chemical binding]; other site 507522008084 catalytic Zn binding site [ion binding]; other site 507522008085 NAD binding site [chemical binding]; other site 507522008086 structural Zn binding site [ion binding]; other site 507522008087 dimer interface [polypeptide binding]; other site 507522008088 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 507522008089 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 507522008090 Trp docking motif [polypeptide binding]; other site 507522008091 putative active site [active] 507522008092 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 507522008093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522008095 dimerization interface [polypeptide binding]; other site 507522008096 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 507522008097 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 507522008098 heterodimer interface [polypeptide binding]; other site 507522008099 active site 507522008100 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 507522008101 heterodimer interface [polypeptide binding]; other site 507522008102 multimer interface [polypeptide binding]; other site 507522008103 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 507522008104 active site 507522008105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 507522008106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 507522008107 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 507522008108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 507522008109 substrate binding pocket [chemical binding]; other site 507522008110 catalytic triad [active] 507522008111 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 507522008112 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 507522008113 catalytic Zn binding site [ion binding]; other site 507522008114 NAD binding site [chemical binding]; other site 507522008115 structural Zn binding site [ion binding]; other site 507522008116 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 507522008117 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 507522008118 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 507522008119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522008120 Coenzyme A binding pocket [chemical binding]; other site 507522008121 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 507522008122 putative trimer interface [polypeptide binding]; other site 507522008123 putative CoA binding site [chemical binding]; other site 507522008124 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 507522008125 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 507522008126 gating phenylalanine in ion channel; other site 507522008127 tellurite resistance protein TehB; Provisional; Region: PRK11207 507522008128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522008129 S-adenosylmethionine binding site [chemical binding]; other site 507522008130 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 507522008131 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522008132 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 507522008133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522008135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008136 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 507522008137 benzoate transporter; Region: benE; TIGR00843 507522008138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522008139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522008140 non-specific DNA binding site [nucleotide binding]; other site 507522008141 salt bridge; other site 507522008142 sequence-specific DNA binding site [nucleotide binding]; other site 507522008143 Cupin domain; Region: Cupin_2; pfam07883 507522008144 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 507522008145 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 507522008146 Peptidase family U32; Region: Peptidase_U32; pfam01136 507522008147 Collagenase; Region: DUF3656; pfam12392 507522008148 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 507522008149 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 507522008150 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 507522008151 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 507522008152 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 507522008153 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 507522008154 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 507522008155 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522008156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522008157 DNA-binding site [nucleotide binding]; DNA binding site 507522008158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522008159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522008160 homodimer interface [polypeptide binding]; other site 507522008161 catalytic residue [active] 507522008162 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 507522008163 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 507522008164 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 507522008165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522008166 Walker A/P-loop; other site 507522008167 ATP binding site [chemical binding]; other site 507522008168 Q-loop/lid; other site 507522008169 ABC transporter signature motif; other site 507522008170 Walker B; other site 507522008171 D-loop; other site 507522008172 H-loop/switch region; other site 507522008173 TOBE domain; Region: TOBE_2; pfam08402 507522008174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008175 dimer interface [polypeptide binding]; other site 507522008176 conserved gate region; other site 507522008177 putative PBP binding loops; other site 507522008178 ABC-ATPase subunit interface; other site 507522008179 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522008180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522008181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008182 putative PBP binding loops; other site 507522008183 dimer interface [polypeptide binding]; other site 507522008184 ABC-ATPase subunit interface; other site 507522008185 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 507522008186 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 507522008187 tetrameric interface [polypeptide binding]; other site 507522008188 NAD binding site [chemical binding]; other site 507522008189 catalytic residues [active] 507522008190 substrate binding site [chemical binding]; other site 507522008191 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 507522008192 PGAP1-like protein; Region: PGAP1; pfam07819 507522008193 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 507522008194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 507522008195 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 507522008196 NAD(P) binding site [chemical binding]; other site 507522008197 catalytic residues [active] 507522008198 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522008199 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 507522008200 peptide binding site [polypeptide binding]; other site 507522008201 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 507522008202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 507522008203 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 507522008204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522008205 Coenzyme A binding pocket [chemical binding]; other site 507522008206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522008207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522008208 sequence-specific DNA binding site [nucleotide binding]; other site 507522008209 salt bridge; other site 507522008210 Cupin domain; Region: Cupin_2; pfam07883 507522008211 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 507522008212 Prostaglandin dehydrogenases; Region: PGDH; cd05288 507522008213 NAD(P) binding site [chemical binding]; other site 507522008214 substrate binding site [chemical binding]; other site 507522008215 dimer interface [polypeptide binding]; other site 507522008216 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 507522008217 active site 507522008218 tetramer interface [polypeptide binding]; other site 507522008219 hypothetical protein; Provisional; Region: PRK09981 507522008220 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 507522008221 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522008222 N-terminal plug; other site 507522008223 ligand-binding site [chemical binding]; other site 507522008224 Uncharacterized conserved protein [Function unknown]; Region: COG3391 507522008225 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 507522008226 L-asparagine permease; Provisional; Region: PRK15049 507522008227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008229 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 507522008230 putative effector binding pocket; other site 507522008231 putative dimerization interface [polypeptide binding]; other site 507522008232 diaminopimelate epimerase; Provisional; Region: PRK13577 507522008233 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 507522008234 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 507522008235 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522008236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522008237 S-adenosylmethionine binding site [chemical binding]; other site 507522008238 AAA domain; Region: AAA_17; pfam13207 507522008239 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 507522008240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 507522008241 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522008242 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 507522008243 metal binding site [ion binding]; metal-binding site 507522008244 dimer interface [polypeptide binding]; other site 507522008245 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 507522008246 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 507522008247 active site 507522008248 non-prolyl cis peptide bond; other site 507522008249 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522008250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522008251 substrate binding pocket [chemical binding]; other site 507522008252 membrane-bound complex binding site; other site 507522008253 hinge residues; other site 507522008254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522008255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522008256 Coenzyme A binding pocket [chemical binding]; other site 507522008257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008258 dimer interface [polypeptide binding]; other site 507522008259 conserved gate region; other site 507522008260 putative PBP binding loops; other site 507522008261 ABC-ATPase subunit interface; other site 507522008262 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522008263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522008264 Walker A/P-loop; other site 507522008265 ATP binding site [chemical binding]; other site 507522008266 Q-loop/lid; other site 507522008267 ABC transporter signature motif; other site 507522008268 Walker B; other site 507522008269 D-loop; other site 507522008270 H-loop/switch region; other site 507522008271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522008272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522008273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522008274 substrate binding pocket [chemical binding]; other site 507522008275 membrane-bound complex binding site; other site 507522008276 hinge residues; other site 507522008277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008278 D-galactonate transporter; Region: 2A0114; TIGR00893 507522008279 putative substrate translocation pore; other site 507522008280 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 507522008281 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 507522008282 active site pocket [active] 507522008283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522008284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522008285 DNA binding site [nucleotide binding] 507522008286 domain linker motif; other site 507522008287 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 507522008288 putative dimerization interface [polypeptide binding]; other site 507522008289 putative ligand binding site [chemical binding]; other site 507522008290 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 507522008291 C-terminal domain interface [polypeptide binding]; other site 507522008292 GSH binding site (G-site) [chemical binding]; other site 507522008293 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522008294 dimer interface [polypeptide binding]; other site 507522008295 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 507522008296 dimer interface [polypeptide binding]; other site 507522008297 N-terminal domain interface [polypeptide binding]; other site 507522008298 substrate binding pocket (H-site) [chemical binding]; other site 507522008299 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 507522008300 active site 1 [active] 507522008301 dimer interface [polypeptide binding]; other site 507522008302 hexamer interface [polypeptide binding]; other site 507522008303 active site 2 [active] 507522008304 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 507522008305 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522008306 trimer interface; other site 507522008307 sugar binding site [chemical binding]; other site 507522008308 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522008309 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 507522008310 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 507522008311 transcriptional activator RhaR; Provisional; Region: PRK13501 507522008312 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522008313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008314 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 507522008315 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 507522008316 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 507522008317 Walker A/P-loop; other site 507522008318 ATP binding site [chemical binding]; other site 507522008319 Q-loop/lid; other site 507522008320 ABC transporter signature motif; other site 507522008321 Walker B; other site 507522008322 D-loop; other site 507522008323 H-loop/switch region; other site 507522008324 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 507522008325 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 507522008326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008327 dimer interface [polypeptide binding]; other site 507522008328 conserved gate region; other site 507522008329 putative PBP binding loops; other site 507522008330 ABC-ATPase subunit interface; other site 507522008331 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 507522008332 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 507522008333 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 507522008334 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 507522008335 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 507522008336 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 507522008337 [4Fe-4S] binding site [ion binding]; other site 507522008338 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008339 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008340 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008341 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008342 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 507522008343 molybdopterin cofactor binding site; other site 507522008344 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 507522008345 TetR family transcriptional regulator; Provisional; Region: PRK14996 507522008346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522008347 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 507522008348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008349 putative substrate translocation pore; other site 507522008350 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 507522008351 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522008352 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522008353 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 507522008354 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 507522008355 octamer interface [polypeptide binding]; other site 507522008356 active site 507522008357 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 507522008358 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 507522008359 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 507522008360 dimer interface [polypeptide binding]; other site 507522008361 active site 507522008362 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 507522008363 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 507522008364 iron-sulfur cluster [ion binding]; other site 507522008365 [2Fe-2S] cluster binding site [ion binding]; other site 507522008366 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 507522008367 putative alpha subunit interface [polypeptide binding]; other site 507522008368 putative active site [active] 507522008369 putative substrate binding site [chemical binding]; other site 507522008370 Fe binding site [ion binding]; other site 507522008371 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 507522008372 inter-subunit interface; other site 507522008373 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 507522008374 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522008375 catalytic loop [active] 507522008376 iron binding site [ion binding]; other site 507522008377 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 507522008378 FAD binding pocket [chemical binding]; other site 507522008379 FAD binding motif [chemical binding]; other site 507522008380 phosphate binding motif [ion binding]; other site 507522008381 beta-alpha-beta structure motif; other site 507522008382 NAD binding pocket [chemical binding]; other site 507522008383 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 507522008384 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 507522008385 putative NAD(P) binding site [chemical binding]; other site 507522008386 active site 507522008387 aromatic amino acid exporter; Provisional; Region: PRK11689 507522008388 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 507522008389 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 507522008390 [4Fe-4S] binding site [ion binding]; other site 507522008391 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008392 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522008393 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 507522008394 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 507522008395 molybdopterin cofactor binding site; other site 507522008396 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 507522008397 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 507522008398 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 507522008399 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 507522008400 CcdB protein; Region: CcdB; cl03380 507522008401 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 507522008402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522008403 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 507522008404 active site 507522008405 metal binding site [ion binding]; metal-binding site 507522008406 MFS transport protein AraJ; Provisional; Region: PRK10091 507522008407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008408 putative substrate translocation pore; other site 507522008409 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 507522008410 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 507522008411 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 507522008412 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 507522008413 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 507522008414 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 507522008415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522008416 Walker A/P-loop; other site 507522008417 ATP binding site [chemical binding]; other site 507522008418 Q-loop/lid; other site 507522008419 ABC transporter signature motif; other site 507522008420 Walker B; other site 507522008421 D-loop; other site 507522008422 H-loop/switch region; other site 507522008423 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522008424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522008425 Walker A/P-loop; other site 507522008426 ATP binding site [chemical binding]; other site 507522008427 Q-loop/lid; other site 507522008428 ABC transporter signature motif; other site 507522008429 Walker B; other site 507522008430 D-loop; other site 507522008431 H-loop/switch region; other site 507522008432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522008433 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 507522008434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008435 ABC-ATPase subunit interface; other site 507522008436 putative PBP binding loops; other site 507522008437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522008438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008439 dimer interface [polypeptide binding]; other site 507522008440 conserved gate region; other site 507522008441 ABC-ATPase subunit interface; other site 507522008442 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522008443 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 507522008444 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 507522008445 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 507522008446 NAD binding site [chemical binding]; other site 507522008447 substrate binding site [chemical binding]; other site 507522008448 catalytic Zn binding site [ion binding]; other site 507522008449 tetramer interface [polypeptide binding]; other site 507522008450 structural Zn binding site [ion binding]; other site 507522008451 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 507522008452 dimer interface [polypeptide binding]; other site 507522008453 substrate binding site [chemical binding]; other site 507522008454 metal binding sites [ion binding]; metal-binding site 507522008455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522008456 MarR family; Region: MarR_2; pfam12802 507522008457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522008458 Coenzyme A binding pocket [chemical binding]; other site 507522008459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522008460 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 507522008461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522008462 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 507522008463 malate dehydrogenase; Provisional; Region: PRK13529 507522008464 Malic enzyme, N-terminal domain; Region: malic; pfam00390 507522008465 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 507522008466 NAD(P) binding site [chemical binding]; other site 507522008467 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 507522008468 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 507522008469 transcriptional regulator; Provisional; Region: PRK10632 507522008470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008471 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522008472 putative effector binding pocket; other site 507522008473 dimerization interface [polypeptide binding]; other site 507522008474 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 507522008475 oxidoreductase; Provisional; Region: PRK06128 507522008476 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 507522008477 NAD binding site [chemical binding]; other site 507522008478 metal binding site [ion binding]; metal-binding site 507522008479 active site 507522008480 General stress protein [General function prediction only]; Region: GsiB; COG3729 507522008481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 507522008482 trehalose synthase; Region: treS_nterm; TIGR02456 507522008483 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 507522008484 active site 507522008485 catalytic site [active] 507522008486 short chain dehydrogenase; Provisional; Region: PRK07109 507522008487 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 507522008488 putative NAD(P) binding site [chemical binding]; other site 507522008489 active site 507522008490 Predicted membrane protein [Function unknown]; Region: COG2323 507522008491 hypothetical protein; Provisional; Region: PRK10053 507522008492 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 507522008493 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 507522008494 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522008495 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522008496 substrate binding pocket [chemical binding]; other site 507522008497 membrane-bound complex binding site; other site 507522008498 hinge residues; other site 507522008499 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 507522008500 Cation efflux family; Region: Cation_efflux; pfam01545 507522008501 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 507522008502 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 507522008503 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 507522008504 putative molybdopterin cofactor binding site [chemical binding]; other site 507522008505 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 507522008506 putative molybdopterin cofactor binding site; other site 507522008507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522008510 dimerization interface [polypeptide binding]; other site 507522008511 benzoate transport; Region: 2A0115; TIGR00895 507522008512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008513 putative substrate translocation pore; other site 507522008514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008515 putative substrate translocation pore; other site 507522008516 Predicted ATPase [General function prediction only]; Region: COG1485 507522008517 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 507522008518 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 507522008519 heme binding site [chemical binding]; other site 507522008520 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 507522008521 heme binding site [chemical binding]; other site 507522008522 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 507522008523 penicillin-binding protein 2; Provisional; Region: PRK10795 507522008524 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 507522008525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 507522008526 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 507522008527 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 507522008528 catalytic triad [active] 507522008529 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 507522008530 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 507522008531 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 507522008532 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 507522008533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522008534 FeS/SAM binding site; other site 507522008535 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 507522008536 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 507522008537 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 507522008538 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 507522008539 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 507522008540 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 507522008541 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 507522008542 active site 507522008543 dimer interface [polypeptide binding]; other site 507522008544 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 507522008545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 507522008546 osmolarity response regulator; Provisional; Region: ompR; PRK09468 507522008547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522008548 active site 507522008549 phosphorylation site [posttranslational modification] 507522008550 intermolecular recognition site; other site 507522008551 dimerization interface [polypeptide binding]; other site 507522008552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522008553 DNA binding site [nucleotide binding] 507522008554 HAMP domain; Region: HAMP; pfam00672 507522008555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522008556 dimer interface [polypeptide binding]; other site 507522008557 phosphorylation site [posttranslational modification] 507522008558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522008559 ATP binding site [chemical binding]; other site 507522008560 Mg2+ binding site [ion binding]; other site 507522008561 G-X-G motif; other site 507522008562 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 507522008563 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 507522008564 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 507522008565 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 507522008566 catalytic residues [active] 507522008567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522008570 dimerization interface [polypeptide binding]; other site 507522008571 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 507522008572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522008573 catalytic residue [active] 507522008574 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 507522008575 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522008576 inhibitor-cofactor binding pocket; inhibition site 507522008577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522008578 catalytic residue [active] 507522008579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 507522008580 NMT1/THI5 like; Region: NMT1; pfam09084 507522008581 membrane-bound complex binding site; other site 507522008582 hinge residues; other site 507522008583 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522008584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008585 dimer interface [polypeptide binding]; other site 507522008586 conserved gate region; other site 507522008587 ABC-ATPase subunit interface; other site 507522008588 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522008589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522008590 Walker A/P-loop; other site 507522008591 ATP binding site [chemical binding]; other site 507522008592 Q-loop/lid; other site 507522008593 ABC transporter signature motif; other site 507522008594 Walker B; other site 507522008595 D-loop; other site 507522008596 H-loop/switch region; other site 507522008597 Putative transcription activator [Transcription]; Region: TenA; COG0819 507522008598 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 507522008599 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522008600 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522008601 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522008602 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 507522008603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522008604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522008605 DNA binding site [nucleotide binding] 507522008606 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 507522008607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522008608 PAS domain; Region: PAS_9; pfam13426 507522008609 putative active site [active] 507522008610 heme pocket [chemical binding]; other site 507522008611 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522008612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522008613 metal binding site [ion binding]; metal-binding site 507522008614 active site 507522008615 I-site; other site 507522008616 guanine deaminase; Provisional; Region: PRK09228 507522008617 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 507522008618 active site 507522008619 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 507522008620 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 507522008621 Na binding site [ion binding]; other site 507522008622 putative substrate binding site [chemical binding]; other site 507522008623 Transcriptional regulators [Transcription]; Region: FadR; COG2186 507522008624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522008625 DNA-binding site [nucleotide binding]; DNA binding site 507522008626 FCD domain; Region: FCD; pfam07729 507522008627 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 507522008628 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 507522008629 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 507522008630 active site 507522008631 catalytic site [active] 507522008632 tetramer interface [polypeptide binding]; other site 507522008633 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 507522008634 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522008635 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522008636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008638 HNH endonuclease; Region: HNH_2; pfam13391 507522008639 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 507522008640 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 507522008641 catalytic triad [active] 507522008642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522008643 Helix-turn-helix domain; Region: HTH_18; pfam12833 507522008644 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 507522008645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008647 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522008648 putative effector binding pocket; other site 507522008649 dimerization interface [polypeptide binding]; other site 507522008650 Protein of unknown function, DUF606; Region: DUF606; pfam04657 507522008651 Protein of unknown function, DUF606; Region: DUF606; pfam04657 507522008652 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 507522008653 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522008654 trimer interface; other site 507522008655 sugar binding site [chemical binding]; other site 507522008656 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522008657 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 507522008658 active site turn [active] 507522008659 phosphorylation site [posttranslational modification] 507522008660 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522008661 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 507522008662 HPr interaction site; other site 507522008663 glycerol kinase (GK) interaction site [polypeptide binding]; other site 507522008664 active site 507522008665 phosphorylation site [posttranslational modification] 507522008666 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 507522008667 beta-galactosidase; Region: BGL; TIGR03356 507522008668 transcriptional antiterminator BglG; Provisional; Region: PRK09772 507522008669 CAT RNA binding domain; Region: CAT_RBD; smart01061 507522008670 PRD domain; Region: PRD; pfam00874 507522008671 PRD domain; Region: PRD; pfam00874 507522008672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522008675 dimerization interface [polypeptide binding]; other site 507522008676 glutathionine S-transferase; Provisional; Region: PRK10542 507522008677 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 507522008678 C-terminal domain interface [polypeptide binding]; other site 507522008679 GSH binding site (G-site) [chemical binding]; other site 507522008680 dimer interface [polypeptide binding]; other site 507522008681 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 507522008682 dimer interface [polypeptide binding]; other site 507522008683 N-terminal domain interface [polypeptide binding]; other site 507522008684 substrate binding pocket (H-site) [chemical binding]; other site 507522008685 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 507522008686 active site 507522008687 P-loop; other site 507522008688 phosphorylation site [posttranslational modification] 507522008689 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 507522008690 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 507522008691 dimer interface [polypeptide binding]; other site 507522008692 active site 507522008693 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 507522008694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008695 putative substrate translocation pore; other site 507522008696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008697 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 507522008698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522008699 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522008700 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522008701 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522008702 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 507522008703 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 507522008704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522008705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522008706 Coenzyme A binding pocket [chemical binding]; other site 507522008707 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 507522008708 amidase; Provisional; Region: PRK09201 507522008709 Amidase; Region: Amidase; pfam01425 507522008710 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 507522008711 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 507522008712 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 507522008713 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522008714 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522008715 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 507522008716 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522008717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522008718 substrate binding pocket [chemical binding]; other site 507522008719 membrane-bound complex binding site; other site 507522008720 hinge residues; other site 507522008721 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522008722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008723 dimer interface [polypeptide binding]; other site 507522008724 conserved gate region; other site 507522008725 putative PBP binding loops; other site 507522008726 ABC-ATPase subunit interface; other site 507522008727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008728 dimer interface [polypeptide binding]; other site 507522008729 conserved gate region; other site 507522008730 putative PBP binding loops; other site 507522008731 ABC-ATPase subunit interface; other site 507522008732 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522008733 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522008734 Walker A/P-loop; other site 507522008735 ATP binding site [chemical binding]; other site 507522008736 Q-loop/lid; other site 507522008737 ABC transporter signature motif; other site 507522008738 Walker B; other site 507522008739 D-loop; other site 507522008740 H-loop/switch region; other site 507522008741 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 507522008742 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 507522008743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522008744 catalytic residue [active] 507522008745 allantoate amidohydrolase; Reviewed; Region: PRK09290 507522008746 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 507522008747 active site 507522008748 metal binding site [ion binding]; metal-binding site 507522008749 dimer interface [polypeptide binding]; other site 507522008750 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 507522008751 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 507522008752 FMN binding site [chemical binding]; other site 507522008753 substrate binding site [chemical binding]; other site 507522008754 putative catalytic residue [active] 507522008755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008757 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522008758 putative effector binding pocket; other site 507522008759 putative dimerization interface [polypeptide binding]; other site 507522008760 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522008761 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 507522008762 active site 507522008763 FMN binding site [chemical binding]; other site 507522008764 substrate binding site [chemical binding]; other site 507522008765 homotetramer interface [polypeptide binding]; other site 507522008766 catalytic residue [active] 507522008767 hypothetical protein; Provisional; Region: PRK09897 507522008768 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 507522008769 putative sialic acid transporter; Region: 2A0112; TIGR00891 507522008770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008771 putative substrate translocation pore; other site 507522008772 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 507522008773 EamA-like transporter family; Region: EamA; pfam00892 507522008774 EamA-like transporter family; Region: EamA; pfam00892 507522008775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522008776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522008777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522008778 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522008779 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 507522008780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008781 putative substrate translocation pore; other site 507522008782 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 507522008783 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 507522008784 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522008785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522008786 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522008787 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 507522008788 Walker A/P-loop; other site 507522008789 ATP binding site [chemical binding]; other site 507522008790 Q-loop/lid; other site 507522008791 ABC transporter signature motif; other site 507522008792 Walker B; other site 507522008793 D-loop; other site 507522008794 H-loop/switch region; other site 507522008795 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 507522008796 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 507522008797 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 507522008798 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 507522008799 urea carboxylase; Region: urea_carbox; TIGR02712 507522008800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 507522008801 ATP-grasp domain; Region: ATP-grasp_4; cl17255 507522008802 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 507522008803 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 507522008804 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 507522008805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 507522008806 carboxyltransferase (CT) interaction site; other site 507522008807 biotinylation site [posttranslational modification]; other site 507522008808 allophanate hydrolase; Provisional; Region: PRK08186 507522008809 Amidase; Region: Amidase; cl11426 507522008810 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 507522008811 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 507522008812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522008813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522008814 DNA binding residues [nucleotide binding] 507522008815 dimerization interface [polypeptide binding]; other site 507522008816 Fimbrial protein; Region: Fimbrial; cl01416 507522008817 Fimbrial protein; Region: Fimbrial; pfam00419 507522008818 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522008819 PapC N-terminal domain; Region: PapC_N; pfam13954 507522008820 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522008821 PapC C-terminal domain; Region: PapC_C; pfam13953 507522008822 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 507522008823 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522008824 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522008825 Fimbrial protein; Region: Fimbrial; cl01416 507522008826 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 507522008827 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 507522008828 ligand binding site [chemical binding]; other site 507522008829 flexible hinge region; other site 507522008830 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 507522008831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 507522008832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008833 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522008834 putative substrate translocation pore; other site 507522008835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008837 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522008838 putative effector binding pocket; other site 507522008839 dimerization interface [polypeptide binding]; other site 507522008840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008842 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522008843 putative effector binding pocket; other site 507522008844 dimerization interface [polypeptide binding]; other site 507522008845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 507522008846 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 507522008847 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 507522008848 metal binding site [ion binding]; metal-binding site 507522008849 dimer interface [polypeptide binding]; other site 507522008850 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 507522008851 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 507522008852 active site 507522008853 substrate binding pocket [chemical binding]; other site 507522008854 homodimer interaction site [polypeptide binding]; other site 507522008855 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522008856 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522008857 TM-ABC transporter signature motif; other site 507522008858 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 507522008859 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522008860 Walker A/P-loop; other site 507522008861 ATP binding site [chemical binding]; other site 507522008862 Q-loop/lid; other site 507522008863 ABC transporter signature motif; other site 507522008864 Walker B; other site 507522008865 D-loop; other site 507522008866 H-loop/switch region; other site 507522008867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522008868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522008869 DNA binding site [nucleotide binding] 507522008870 domain linker motif; other site 507522008871 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 507522008872 putative dimerization interface [polypeptide binding]; other site 507522008873 putative ligand binding site [chemical binding]; other site 507522008874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522008875 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 507522008876 ligand binding site [chemical binding]; other site 507522008877 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522008878 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 507522008879 substrate binding site [chemical binding]; other site 507522008880 dimer interface [polypeptide binding]; other site 507522008881 ATP binding site [chemical binding]; other site 507522008882 BtpA family; Region: BtpA; cl00440 507522008883 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 507522008884 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522008885 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 507522008886 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522008887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522008888 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 507522008889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522008890 dimer interface [polypeptide binding]; other site 507522008891 conserved gate region; other site 507522008892 ABC-ATPase subunit interface; other site 507522008893 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 507522008894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522008895 Walker A/P-loop; other site 507522008896 ATP binding site [chemical binding]; other site 507522008897 Q-loop/lid; other site 507522008898 ABC transporter signature motif; other site 507522008899 Walker B; other site 507522008900 D-loop; other site 507522008901 H-loop/switch region; other site 507522008902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 507522008903 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522008904 Walker A/P-loop; other site 507522008905 ATP binding site [chemical binding]; other site 507522008906 Q-loop/lid; other site 507522008907 ABC transporter signature motif; other site 507522008908 Walker B; other site 507522008909 D-loop; other site 507522008910 H-loop/switch region; other site 507522008911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522008912 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 507522008913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008914 putative substrate translocation pore; other site 507522008915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008916 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 507522008917 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522008918 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522008919 MarR family; Region: MarR_2; cl17246 507522008920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522008921 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 507522008922 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 507522008923 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 507522008924 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 507522008925 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 507522008926 conserved cys residue [active] 507522008927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522008929 MltA-interacting protein MipA; Region: MipA; cl01504 507522008930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 507522008931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522008932 active site 507522008933 phosphorylation site [posttranslational modification] 507522008934 intermolecular recognition site; other site 507522008935 dimerization interface [polypeptide binding]; other site 507522008936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522008937 DNA binding site [nucleotide binding] 507522008938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 507522008939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 507522008940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522008941 dimer interface [polypeptide binding]; other site 507522008942 phosphorylation site [posttranslational modification] 507522008943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522008944 ATP binding site [chemical binding]; other site 507522008945 Mg2+ binding site [ion binding]; other site 507522008946 G-X-G motif; other site 507522008947 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522008948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522008949 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522008950 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522008951 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 507522008952 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 507522008953 heme-binding site [chemical binding]; other site 507522008954 amidase; Provisional; Region: PRK07235 507522008955 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 507522008956 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 507522008957 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 507522008958 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 507522008959 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 507522008960 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 507522008961 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 507522008962 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 507522008963 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 507522008964 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 507522008965 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 507522008966 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 507522008967 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 507522008968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522008969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522008970 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 507522008971 putative dimerization interface [polypeptide binding]; other site 507522008972 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522008973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522008974 DNA-binding site [nucleotide binding]; DNA binding site 507522008975 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 507522008976 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 507522008977 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522008978 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522008979 active site turn [active] 507522008980 phosphorylation site [posttranslational modification] 507522008981 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 507522008982 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 507522008983 NAD binding site [chemical binding]; other site 507522008984 sugar binding site [chemical binding]; other site 507522008985 divalent metal binding site [ion binding]; other site 507522008986 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522008987 dimer interface [polypeptide binding]; other site 507522008988 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 507522008989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008990 putative substrate translocation pore; other site 507522008991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522008992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522008993 active site 507522008994 phosphorylation site [posttranslational modification] 507522008995 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 507522008996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522008997 PAS domain; Region: PAS_9; pfam13426 507522008998 putative active site [active] 507522008999 heme pocket [chemical binding]; other site 507522009000 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522009001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522009002 metal binding site [ion binding]; metal-binding site 507522009003 active site 507522009004 I-site; other site 507522009005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522009006 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 507522009007 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 507522009008 active site 507522009009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 507522009010 Beta-lactamase; Region: Beta-lactamase; pfam00144 507522009011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522009012 non-specific DNA binding site [nucleotide binding]; other site 507522009013 salt bridge; other site 507522009014 sequence-specific DNA binding site [nucleotide binding]; other site 507522009015 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522009016 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522009017 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522009018 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522009019 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522009020 PapC N-terminal domain; Region: PapC_N; pfam13954 507522009021 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522009022 PapC C-terminal domain; Region: PapC_C; pfam13953 507522009023 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522009024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 507522009025 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 507522009026 HipA N-terminal domain; Region: Couple_hipA; pfam13657 507522009027 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 507522009028 HipA-like N-terminal domain; Region: HipA_N; pfam07805 507522009029 HipA-like C-terminal domain; Region: HipA_C; pfam07804 507522009030 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522009031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522009032 non-specific DNA binding site [nucleotide binding]; other site 507522009033 salt bridge; other site 507522009034 sequence-specific DNA binding site [nucleotide binding]; other site 507522009035 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 507522009036 active site 507522009037 homotetramer interface [polypeptide binding]; other site 507522009038 OHCU decarboxylase; Region: UraD_2; TIGR03180 507522009039 xanthine permease; Region: pbuX; TIGR03173 507522009040 hypothetical protein; Provisional; Region: PRK07236 507522009041 FAD binding domain; Region: FAD_binding_3; pfam01494 507522009042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009043 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 507522009044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522009045 dimerization interface [polypeptide binding]; other site 507522009046 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 507522009047 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 507522009048 [2Fe-2S] cluster binding site [ion binding]; other site 507522009049 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 507522009050 hydrophobic ligand binding site; other site 507522009051 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 507522009052 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 507522009053 FMN-binding pocket [chemical binding]; other site 507522009054 flavin binding motif; other site 507522009055 phosphate binding motif [ion binding]; other site 507522009056 beta-alpha-beta structure motif; other site 507522009057 NAD binding pocket [chemical binding]; other site 507522009058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522009059 catalytic loop [active] 507522009060 iron binding site [ion binding]; other site 507522009061 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 507522009062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009063 putative substrate translocation pore; other site 507522009064 Cupin; Region: Cupin_6; pfam12852 507522009065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522009066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009068 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 507522009069 Cupin domain; Region: Cupin_2; cl17218 507522009070 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 507522009071 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 507522009072 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 507522009073 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 507522009074 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 507522009075 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 507522009076 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522009077 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 507522009078 Walker A/P-loop; other site 507522009079 ATP binding site [chemical binding]; other site 507522009080 Q-loop/lid; other site 507522009081 ABC transporter signature motif; other site 507522009082 Walker B; other site 507522009083 D-loop; other site 507522009084 H-loop/switch region; other site 507522009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522009086 dimer interface [polypeptide binding]; other site 507522009087 conserved gate region; other site 507522009088 ABC-ATPase subunit interface; other site 507522009089 Nitronate monooxygenase; Region: NMO; pfam03060 507522009090 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 507522009091 FMN binding site [chemical binding]; other site 507522009092 substrate binding site [chemical binding]; other site 507522009093 putative catalytic residue [active] 507522009094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522009097 dimerization interface [polypeptide binding]; other site 507522009098 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 507522009099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 507522009100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522009101 active site 507522009102 major facilitator superfamily transporter; Provisional; Region: PRK05122 507522009103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009104 putative substrate translocation pore; other site 507522009105 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 507522009106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522009107 S-adenosylmethionine binding site [chemical binding]; other site 507522009108 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 507522009109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 507522009110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522009111 Coenzyme A binding pocket [chemical binding]; other site 507522009112 altronate oxidoreductase; Provisional; Region: PRK03643 507522009113 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522009114 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522009115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522009116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522009117 Coenzyme A binding pocket [chemical binding]; other site 507522009118 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522009119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522009120 metal binding site [ion binding]; metal-binding site 507522009121 active site 507522009122 I-site; other site 507522009123 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 507522009124 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 507522009125 glutaminase; Provisional; Region: PRK00971 507522009126 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 507522009127 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 507522009128 NAD(P) binding site [chemical binding]; other site 507522009129 catalytic residues [active] 507522009130 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 507522009131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009132 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 507522009133 putative dimerization interface [polypeptide binding]; other site 507522009134 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522009135 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 507522009136 tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522009137 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 507522009138 NAD binding site [chemical binding]; other site 507522009139 dimer interface [polypeptide binding]; other site 507522009140 substrate binding site [chemical binding]; other site 507522009141 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522009142 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522009143 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522009144 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 507522009145 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 507522009146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 507522009147 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 507522009148 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 507522009149 active site 507522009150 NAD binding site [chemical binding]; other site 507522009151 metal binding site [ion binding]; metal-binding site 507522009152 dihydrodipicolinate synthase; Region: dapA; TIGR00674 507522009153 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 507522009154 inhibitor site; inhibition site 507522009155 active site 507522009156 dimer interface [polypeptide binding]; other site 507522009157 catalytic residue [active] 507522009158 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 507522009159 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 507522009160 putative ligand binding site [chemical binding]; other site 507522009161 putative NAD binding site [chemical binding]; other site 507522009162 catalytic site [active] 507522009163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009164 D-galactonate transporter; Region: 2A0114; TIGR00893 507522009165 putative substrate translocation pore; other site 507522009166 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 507522009167 putative arabinose transporter; Provisional; Region: PRK03545 507522009168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009169 putative substrate translocation pore; other site 507522009170 inner membrane protein; Provisional; Region: PRK10995 507522009171 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 507522009172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522009173 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 507522009174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009176 MarB protein; Region: MarB; pfam13999 507522009177 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 507522009178 putative transporter; Provisional; Region: PRK10054 507522009179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009180 putative substrate translocation pore; other site 507522009181 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522009182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522009183 non-specific DNA binding site [nucleotide binding]; other site 507522009184 salt bridge; other site 507522009185 sequence-specific DNA binding site [nucleotide binding]; other site 507522009186 2TM domain; Region: 2TM; pfam13239 507522009187 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 507522009188 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 507522009189 Walker A/P-loop; other site 507522009190 ATP binding site [chemical binding]; other site 507522009191 Q-loop/lid; other site 507522009192 ABC transporter signature motif; other site 507522009193 Walker B; other site 507522009194 D-loop; other site 507522009195 H-loop/switch region; other site 507522009196 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 507522009197 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 507522009198 Walker A/P-loop; other site 507522009199 ATP binding site [chemical binding]; other site 507522009200 Q-loop/lid; other site 507522009201 ABC transporter signature motif; other site 507522009202 Walker B; other site 507522009203 D-loop; other site 507522009204 H-loop/switch region; other site 507522009205 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 507522009206 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 507522009207 TM-ABC transporter signature motif; other site 507522009208 HEAT repeats; Region: HEAT_2; pfam13646 507522009209 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 507522009210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522009211 TM-ABC transporter signature motif; other site 507522009212 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 507522009213 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 507522009214 putative ligand binding site [chemical binding]; other site 507522009215 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 507522009216 substrate binding site [chemical binding]; other site 507522009217 THF binding site; other site 507522009218 zinc-binding site [ion binding]; other site 507522009219 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 507522009220 active site residue [active] 507522009221 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 507522009222 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 507522009223 conserved cys residue [active] 507522009224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522009227 Coenzyme A binding pocket [chemical binding]; other site 507522009228 lac repressor; Reviewed; Region: lacI; PRK09526 507522009229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522009230 DNA binding site [nucleotide binding] 507522009231 domain linker motif; other site 507522009232 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 507522009233 ligand binding site [chemical binding]; other site 507522009234 dimerization interface (open form) [polypeptide binding]; other site 507522009235 dimerization interface (closed form) [polypeptide binding]; other site 507522009236 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 507522009237 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 507522009238 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 507522009239 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 507522009240 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 507522009241 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 507522009242 Predicted ATPase [General function prediction only]; Region: COG4637 507522009243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522009244 Walker A/P-loop; other site 507522009245 ATP binding site [chemical binding]; other site 507522009246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522009247 ABC transporter signature motif; other site 507522009248 Walker B; other site 507522009249 D-loop; other site 507522009250 H-loop/switch region; other site 507522009251 beta-lactamase TEM; Provisional; Region: PRK15442 507522009252 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 507522009253 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522009254 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522009255 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522009256 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 507522009257 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522009258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 507522009259 putative aldolase; Validated; Region: PRK08130 507522009260 active site 507522009261 intersubunit interface [polypeptide binding]; other site 507522009262 Zn2+ binding site [ion binding]; other site 507522009263 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 507522009264 putative transporter; Provisional; Region: PRK09821 507522009265 GntP family permease; Region: GntP_permease; pfam02447 507522009266 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 507522009267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009268 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 507522009269 Sensors of blue-light using FAD; Region: BLUF; smart01034 507522009270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522009271 hypothetical protein; Validated; Region: PRK03657 507522009272 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 507522009273 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 507522009274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522009275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522009276 DNA binding residues [nucleotide binding] 507522009277 dimerization interface [polypeptide binding]; other site 507522009278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522009279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522009280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009281 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522009282 putative effector binding pocket; other site 507522009283 dimerization interface [polypeptide binding]; other site 507522009284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522009285 Walker A/P-loop; other site 507522009286 ATP binding site [chemical binding]; other site 507522009287 beta-lactamase TEM; Provisional; Region: PRK15442 507522009288 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 507522009289 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522009290 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522009291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522009292 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 507522009293 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522009294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 507522009295 putative aldolase; Validated; Region: PRK08130 507522009296 active site 507522009297 intersubunit interface [polypeptide binding]; other site 507522009298 Zn2+ binding site [ion binding]; other site 507522009299 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 507522009300 putative transporter; Provisional; Region: PRK09821 507522009301 GntP family permease; Region: GntP_permease; pfam02447 507522009302 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 507522009303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009304 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 507522009305 Sensors of blue-light using FAD; Region: BLUF; smart01034 507522009306 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522009307 hypothetical protein; Validated; Region: PRK03657 507522009308 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 507522009309 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 507522009310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522009311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522009312 DNA binding residues [nucleotide binding] 507522009313 dimerization interface [polypeptide binding]; other site 507522009314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 507522009315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522009316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009317 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522009318 putative effector binding pocket; other site 507522009319 dimerization interface [polypeptide binding]; other site 507522009320 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 507522009321 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 507522009322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522009323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522009324 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 507522009325 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 507522009326 putative NAD(P) binding site [chemical binding]; other site 507522009327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009329 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 507522009330 putative effector binding pocket; other site 507522009331 putative dimerization interface [polypeptide binding]; other site 507522009332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009333 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 507522009334 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 507522009335 dimerization interface [polypeptide binding]; other site 507522009336 substrate binding pocket [chemical binding]; other site 507522009337 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 507522009338 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522009339 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522009340 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 507522009341 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 507522009342 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 507522009343 active site 507522009344 catalytic residues [active] 507522009345 DNA binding site [nucleotide binding] 507522009346 Int/Topo IB signature motif; other site 507522009347 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 507522009348 active site 507522009349 catalytic residues [active] 507522009350 DNA binding site [nucleotide binding] 507522009351 Int/Topo IB signature motif; other site 507522009352 WYL domain; Region: WYL; pfam13280 507522009353 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 507522009354 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 507522009355 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 507522009356 ATP binding site [chemical binding]; other site 507522009357 substrate interface [chemical binding]; other site 507522009358 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 507522009359 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 507522009360 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 507522009361 Catalytic site [active] 507522009362 DinI-like family; Region: DinI; pfam06183 507522009363 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 507522009364 multiple promoter invertase; Provisional; Region: mpi; PRK13413 507522009365 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 507522009366 catalytic residues [active] 507522009367 catalytic nucleophile [active] 507522009368 Presynaptic Site I dimer interface [polypeptide binding]; other site 507522009369 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 507522009370 Synaptic Flat tetramer interface [polypeptide binding]; other site 507522009371 Synaptic Site I dimer interface [polypeptide binding]; other site 507522009372 DNA binding site [nucleotide binding] 507522009373 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 507522009374 DNA-binding interface [nucleotide binding]; DNA binding site 507522009375 TolA protein; Region: tolA_full; TIGR02794 507522009376 TolA C-terminal; Region: TolA; pfam06519 507522009377 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 507522009378 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 507522009379 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522009380 catalytic residue [active] 507522009381 phage holin, lambda family; Region: holin_lambda; TIGR01594 507522009382 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 507522009383 Antitermination protein; Region: Antiterm; pfam03589 507522009384 Antitermination protein; Region: Antiterm; pfam03589 507522009385 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 507522009386 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 507522009387 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 507522009388 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 507522009389 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 507522009390 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 507522009391 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 507522009392 active site 507522009393 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 507522009394 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 507522009395 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 507522009396 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 507522009397 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522009398 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 507522009399 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 507522009400 dimer interface [polypeptide binding]; other site 507522009401 active site 507522009402 Int/Topo IB signature motif; other site 507522009403 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 507522009404 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 507522009405 active site 507522009406 Zn binding site [ion binding]; other site 507522009407 malonic semialdehyde reductase; Provisional; Region: PRK10538 507522009408 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 507522009409 putative NAD(P) binding site [chemical binding]; other site 507522009410 homodimer interface [polypeptide binding]; other site 507522009411 homotetramer interface [polypeptide binding]; other site 507522009412 active site 507522009413 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522009414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522009415 DNA-binding site [nucleotide binding]; DNA binding site 507522009416 FCD domain; Region: FCD; pfam07729 507522009417 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522009418 Ligand Binding Site [chemical binding]; other site 507522009419 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 507522009420 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522009421 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522009422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009423 D-galactonate transporter; Region: 2A0114; TIGR00893 507522009424 putative substrate translocation pore; other site 507522009425 hypothetical protein; Provisional; Region: PRK02237 507522009426 hypothetical protein; Provisional; Region: PRK13659 507522009427 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 507522009428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522009429 Coenzyme A binding pocket [chemical binding]; other site 507522009430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522009431 lipoprotein; Reviewed; Region: PRK02939 507522009432 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 507522009433 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 507522009434 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 507522009435 putative [Fe4-S4] binding site [ion binding]; other site 507522009436 putative molybdopterin cofactor binding site [chemical binding]; other site 507522009437 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 507522009438 putative molybdopterin cofactor binding site; other site 507522009439 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 507522009440 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 507522009441 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 507522009442 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 507522009443 Cl- selectivity filter; other site 507522009444 Cl- binding residues [ion binding]; other site 507522009445 pore gating glutamate residue; other site 507522009446 dimer interface [polypeptide binding]; other site 507522009447 putative dithiobiotin synthetase; Provisional; Region: PRK12374 507522009448 AAA domain; Region: AAA_26; pfam13500 507522009449 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 507522009450 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 507522009451 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522009452 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 507522009453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009454 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 507522009455 dimerization interface [polypeptide binding]; other site 507522009456 substrate binding pocket [chemical binding]; other site 507522009457 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522009458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009459 putative substrate translocation pore; other site 507522009460 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 507522009461 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 507522009462 active site 507522009463 Zn binding site [ion binding]; other site 507522009464 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 507522009465 CHASE4 domain; Region: CHASE4; pfam05228 507522009466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522009467 metal binding site [ion binding]; metal-binding site 507522009468 active site 507522009469 I-site; other site 507522009470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522009471 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 507522009472 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 507522009473 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 507522009474 Domain of unknown function DUF20; Region: UPF0118; pfam01594 507522009475 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 507522009476 Coenzyme A transferase; Region: CoA_trans; cl17247 507522009477 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 507522009478 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 507522009479 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 507522009480 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 507522009481 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 507522009482 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 507522009483 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 507522009484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522009487 dimerization interface [polypeptide binding]; other site 507522009488 malate:quinone oxidoreductase; Validated; Region: PRK05257 507522009489 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 507522009490 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 507522009491 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 507522009492 putative active site [active] 507522009493 sensory histidine kinase DcuS; Provisional; Region: PRK11086 507522009494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522009495 ATP binding site [chemical binding]; other site 507522009496 Mg2+ binding site [ion binding]; other site 507522009497 G-X-G motif; other site 507522009498 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 507522009499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522009500 active site 507522009501 phosphorylation site [posttranslational modification] 507522009502 intermolecular recognition site; other site 507522009503 dimerization interface [polypeptide binding]; other site 507522009504 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 507522009505 ApbE family; Region: ApbE; pfam02424 507522009506 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522009507 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 507522009508 putative active site [active] 507522009509 putative FMN binding site [chemical binding]; other site 507522009510 putative substrate binding site [chemical binding]; other site 507522009511 putative catalytic residue [active] 507522009512 FMN-binding domain; Region: FMN_bind; cl01081 507522009513 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 507522009514 L-aspartate oxidase; Provisional; Region: PRK06175 507522009515 Predicted oxidoreductase [General function prediction only]; Region: COG3573 507522009516 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522009517 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 507522009518 transmembrane helices; other site 507522009519 fumarate hydratase; Provisional; Region: PRK15389 507522009520 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 507522009521 Fumarase C-terminus; Region: Fumerase_C; pfam05683 507522009522 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 507522009523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522009524 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 507522009525 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 507522009526 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 507522009527 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 507522009528 tetramer interface [polypeptide binding]; other site 507522009529 active site 507522009530 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 507522009531 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522009532 dimer interface [polypeptide binding]; other site 507522009533 active site 507522009534 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 507522009535 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 507522009536 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 507522009537 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522009538 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522009539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 507522009540 Smr domain; Region: Smr; pfam01713 507522009541 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 507522009542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522009544 dimerization interface [polypeptide binding]; other site 507522009545 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 507522009546 amidohydrolase; Region: amidohydrolases; TIGR01891 507522009547 putative metal binding site [ion binding]; other site 507522009548 dimer interface [polypeptide binding]; other site 507522009549 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 507522009550 amidohydrolase; Region: amidohydrolases; TIGR01891 507522009551 putative metal binding site [ion binding]; other site 507522009552 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 507522009553 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 507522009554 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 507522009555 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 507522009556 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 507522009557 DNA binding site [nucleotide binding] 507522009558 active site 507522009559 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 507522009560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 507522009561 ligand binding site [chemical binding]; other site 507522009562 flexible hinge region; other site 507522009563 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 507522009564 putative switch regulator; other site 507522009565 non-specific DNA interactions [nucleotide binding]; other site 507522009566 DNA binding site [nucleotide binding] 507522009567 sequence specific DNA binding site [nucleotide binding]; other site 507522009568 putative cAMP binding site [chemical binding]; other site 507522009569 universal stress protein UspE; Provisional; Region: PRK11175 507522009570 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522009571 Ligand Binding Site [chemical binding]; other site 507522009572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522009573 Ligand Binding Site [chemical binding]; other site 507522009574 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 507522009575 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 507522009576 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 507522009577 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 507522009578 ligand binding site [chemical binding]; other site 507522009579 homodimer interface [polypeptide binding]; other site 507522009580 NAD(P) binding site [chemical binding]; other site 507522009581 trimer interface B [polypeptide binding]; other site 507522009582 trimer interface A [polypeptide binding]; other site 507522009583 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 507522009584 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522009585 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522009586 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522009587 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 507522009588 Spore germination protein; Region: Spore_permease; cl17796 507522009589 dihydromonapterin reductase; Provisional; Region: PRK06483 507522009590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522009591 NAD(P) binding site [chemical binding]; other site 507522009592 active site 507522009593 GlpM protein; Region: GlpM; pfam06942 507522009594 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 507522009595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522009596 active site 507522009597 phosphorylation site [posttranslational modification] 507522009598 intermolecular recognition site; other site 507522009599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522009600 DNA binding site [nucleotide binding] 507522009601 sensor protein RstB; Provisional; Region: PRK10604 507522009602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522009603 dimerization interface [polypeptide binding]; other site 507522009604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522009605 dimer interface [polypeptide binding]; other site 507522009606 phosphorylation site [posttranslational modification] 507522009607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522009608 ATP binding site [chemical binding]; other site 507522009609 Mg2+ binding site [ion binding]; other site 507522009610 G-X-G motif; other site 507522009611 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 507522009612 fumarate hydratase; Reviewed; Region: fumC; PRK00485 507522009613 Class II fumarases; Region: Fumarase_classII; cd01362 507522009614 active site 507522009615 tetramer interface [polypeptide binding]; other site 507522009616 fumarate hydratase; Provisional; Region: PRK15389 507522009617 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 507522009618 Fumarase C-terminus; Region: Fumerase_C; pfam05683 507522009619 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 507522009620 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 507522009621 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 507522009622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 507522009623 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 507522009624 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 507522009625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522009626 DNA binding site [nucleotide binding] 507522009627 domain linker motif; other site 507522009628 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 507522009629 putative dimerization interface [polypeptide binding]; other site 507522009630 putative ligand binding site [chemical binding]; other site 507522009631 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 507522009632 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 507522009633 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522009634 active site turn [active] 507522009635 phosphorylation site [posttranslational modification] 507522009636 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 507522009637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522009638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522009639 homodimer interface [polypeptide binding]; other site 507522009640 catalytic residue [active] 507522009641 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 507522009642 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 507522009643 Cl binding site [ion binding]; other site 507522009644 oligomer interface [polypeptide binding]; other site 507522009645 YdfZ protein; Region: YdfZ; pfam14001 507522009646 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 507522009647 putative inner membrane protein; Provisional; Region: PRK11099 507522009648 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 507522009649 CPxP motif; other site 507522009650 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 507522009651 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 507522009652 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 507522009653 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 507522009654 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 507522009655 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 507522009656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 507522009657 NAD binding site [chemical binding]; other site 507522009658 catalytic residues [active] 507522009659 substrate binding site [chemical binding]; other site 507522009660 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 507522009661 putative active site [active] 507522009662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009663 metabolite-proton symporter; Region: 2A0106; TIGR00883 507522009664 putative substrate translocation pore; other site 507522009665 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 507522009666 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 507522009667 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 507522009668 putative active site [active] 507522009669 Zn binding site [ion binding]; other site 507522009670 succinylarginine dihydrolase; Provisional; Region: PRK13281 507522009671 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 507522009672 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 507522009673 NAD(P) binding site [chemical binding]; other site 507522009674 catalytic residues [active] 507522009675 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 507522009676 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 507522009677 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 507522009678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522009679 inhibitor-cofactor binding pocket; inhibition site 507522009680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522009681 catalytic residue [active] 507522009682 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 507522009683 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 507522009684 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 507522009685 NAD(P) binding site [chemical binding]; other site 507522009686 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 507522009687 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 507522009688 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 507522009689 putative acyltransferase; Provisional; Region: PRK05790 507522009690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522009691 dimer interface [polypeptide binding]; other site 507522009692 active site 507522009693 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 507522009694 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 507522009695 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 507522009696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522009697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522009698 active site 507522009699 catalytic tetrad [active] 507522009700 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522009701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009702 putative substrate translocation pore; other site 507522009703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522009704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522009705 active site 507522009706 catalytic tetrad [active] 507522009707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009709 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 507522009710 putative effector binding pocket; other site 507522009711 putative dimerization interface [polypeptide binding]; other site 507522009712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522009713 MarR family; Region: MarR_2; pfam12802 507522009714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522009715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522009716 putative substrate translocation pore; other site 507522009717 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 507522009718 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522009719 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522009720 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 507522009721 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 507522009722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 507522009723 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 507522009724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522009725 ATP binding site [chemical binding]; other site 507522009726 putative Mg++ binding site [ion binding]; other site 507522009727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522009728 nucleotide binding region [chemical binding]; other site 507522009729 ATP-binding site [chemical binding]; other site 507522009730 Helicase associated domain (HA2); Region: HA2; pfam04408 507522009731 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 507522009732 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 507522009733 azoreductase; Reviewed; Region: PRK00170 507522009734 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522009735 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 507522009736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522009737 non-specific DNA binding site [nucleotide binding]; other site 507522009738 salt bridge; other site 507522009739 sequence-specific DNA binding site [nucleotide binding]; other site 507522009740 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 507522009741 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 507522009742 putative trimer interface [polypeptide binding]; other site 507522009743 putative metal binding site [ion binding]; other site 507522009744 PaaX-like protein; Region: PaaX; pfam07848 507522009745 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 507522009746 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 507522009747 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 507522009748 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 507522009749 active site 507522009750 AMP binding site [chemical binding]; other site 507522009751 homodimer interface [polypeptide binding]; other site 507522009752 acyl-activating enzyme (AAE) consensus motif; other site 507522009753 CoA binding site [chemical binding]; other site 507522009754 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 507522009755 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522009756 dimer interface [polypeptide binding]; other site 507522009757 active site 507522009758 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 507522009759 CoenzymeA binding site [chemical binding]; other site 507522009760 subunit interaction site [polypeptide binding]; other site 507522009761 PHB binding site; other site 507522009762 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 507522009763 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522009764 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522009765 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522009766 enoyl-CoA hydratase; Provisional; Region: PRK08140 507522009767 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 507522009768 substrate binding site [chemical binding]; other site 507522009769 oxyanion hole (OAH) forming residues; other site 507522009770 trimer interface [polypeptide binding]; other site 507522009771 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 507522009772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 507522009773 substrate binding site [chemical binding]; other site 507522009774 oxyanion hole (OAH) forming residues; other site 507522009775 trimer interface [polypeptide binding]; other site 507522009776 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 507522009777 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 507522009778 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 507522009779 FAD binding pocket [chemical binding]; other site 507522009780 FAD binding motif [chemical binding]; other site 507522009781 phosphate binding motif [ion binding]; other site 507522009782 beta-alpha-beta structure motif; other site 507522009783 NAD(p) ribose binding residues [chemical binding]; other site 507522009784 NAD binding pocket [chemical binding]; other site 507522009785 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 507522009786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522009787 catalytic loop [active] 507522009788 iron binding site [ion binding]; other site 507522009789 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 507522009790 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 507522009791 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 507522009792 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 507522009793 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 507522009794 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 507522009795 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 507522009796 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 507522009797 substrate binding site [chemical binding]; other site 507522009798 dimer interface [polypeptide binding]; other site 507522009799 NADP binding site [chemical binding]; other site 507522009800 catalytic residues [active] 507522009801 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 507522009802 substrate binding site [chemical binding]; other site 507522009803 tyramine oxidase; Provisional; Region: tynA; PRK14696 507522009804 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 507522009805 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 507522009806 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 507522009807 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 507522009808 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522009809 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 507522009810 NADP binding site [chemical binding]; other site 507522009811 dimer interface [polypeptide binding]; other site 507522009812 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 507522009813 acetylornithine deacetylase; Provisional; Region: PRK07522 507522009814 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 507522009815 metal binding site [ion binding]; metal-binding site 507522009816 putative dimer interface [polypeptide binding]; other site 507522009817 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 507522009818 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 507522009819 homotrimer interaction site [polypeptide binding]; other site 507522009820 putative active site [active] 507522009821 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 507522009822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522009823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009825 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 507522009826 putative substrate binding pocket [chemical binding]; other site 507522009827 dimerization interface [polypeptide binding]; other site 507522009828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522009829 dimer interface [polypeptide binding]; other site 507522009830 conserved gate region; other site 507522009831 putative PBP binding loops; other site 507522009832 ABC-ATPase subunit interface; other site 507522009833 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522009834 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522009835 Walker A/P-loop; other site 507522009836 ATP binding site [chemical binding]; other site 507522009837 Q-loop/lid; other site 507522009838 ABC transporter signature motif; other site 507522009839 Walker B; other site 507522009840 D-loop; other site 507522009841 H-loop/switch region; other site 507522009842 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 507522009843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522009844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522009845 substrate binding pocket [chemical binding]; other site 507522009846 membrane-bound complex binding site; other site 507522009847 hinge residues; other site 507522009848 hypothetical protein; Provisional; Region: PRK07490 507522009849 intersubunit interface [polypeptide binding]; other site 507522009850 active site 507522009851 Zn2+ binding site [ion binding]; other site 507522009852 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 507522009853 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 507522009854 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 507522009855 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 507522009856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 507522009857 NAD(P) binding site [chemical binding]; other site 507522009858 catalytic residues [active] 507522009859 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 507522009860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 507522009862 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 507522009863 hypothetical protein; Provisional; Region: PRK10695 507522009864 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522009865 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522009866 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 507522009867 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 507522009868 putative ligand binding site [chemical binding]; other site 507522009869 putative NAD binding site [chemical binding]; other site 507522009870 catalytic site [active] 507522009871 META domain; Region: META; cl01245 507522009872 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 507522009873 Domain of unknown function (DUF333); Region: DUF333; pfam03891 507522009874 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 507522009875 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 507522009876 dimer interface [polypeptide binding]; other site 507522009877 PYR/PP interface [polypeptide binding]; other site 507522009878 TPP binding site [chemical binding]; other site 507522009879 substrate binding site [chemical binding]; other site 507522009880 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 507522009881 Domain of unknown function; Region: EKR; pfam10371 507522009882 4Fe-4S binding domain; Region: Fer4_6; pfam12837 507522009883 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522009884 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 507522009885 TPP-binding site [chemical binding]; other site 507522009886 dimer interface [polypeptide binding]; other site 507522009887 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522009888 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 507522009889 trimer interface [polypeptide binding]; other site 507522009890 eyelet of channel; other site 507522009891 KTSC domain; Region: KTSC; pfam13619 507522009892 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522009893 Ligand Binding Site [chemical binding]; other site 507522009894 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 507522009895 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 507522009896 Ligand Binding Site [chemical binding]; other site 507522009897 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 507522009898 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 507522009899 ATP binding site [chemical binding]; other site 507522009900 Mg++ binding site [ion binding]; other site 507522009901 motif III; other site 507522009902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522009903 nucleotide binding region [chemical binding]; other site 507522009904 ATP-binding site [chemical binding]; other site 507522009905 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 507522009906 putative RNA binding site [nucleotide binding]; other site 507522009907 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 507522009908 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 507522009909 Cl binding site [ion binding]; other site 507522009910 oligomer interface [polypeptide binding]; other site 507522009911 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522009912 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522009913 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522009914 putative oxidoreductase; Provisional; Region: PRK11579 507522009915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522009916 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522009917 aromatic amino acid transporter; Provisional; Region: PRK10238 507522009918 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 507522009919 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 507522009920 putative DNA binding site [nucleotide binding]; other site 507522009921 putative Zn2+ binding site [ion binding]; other site 507522009922 AsnC family; Region: AsnC_trans_reg; pfam01037 507522009923 Uncharacterized conserved protein [Function unknown]; Region: COG1284 507522009924 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 507522009925 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 507522009926 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 507522009927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522009928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522009929 homodimer interface [polypeptide binding]; other site 507522009930 catalytic residue [active] 507522009931 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 507522009932 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 507522009933 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 507522009934 Walker A/P-loop; other site 507522009935 ATP binding site [chemical binding]; other site 507522009936 Q-loop/lid; other site 507522009937 ABC transporter signature motif; other site 507522009938 Walker B; other site 507522009939 D-loop; other site 507522009940 H-loop/switch region; other site 507522009941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522009942 NIL domain; Region: NIL; pfam09383 507522009943 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 507522009944 transaminase; Reviewed; Region: PRK08068 507522009945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522009946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522009947 homodimer interface [polypeptide binding]; other site 507522009948 catalytic residue [active] 507522009949 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522009950 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 507522009951 putative NAD(P) binding site [chemical binding]; other site 507522009952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522009953 NmrA-like family; Region: NmrA; pfam05368 507522009954 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 507522009955 NADP binding site [chemical binding]; other site 507522009956 active site 507522009957 regulatory binding site [polypeptide binding]; other site 507522009958 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 507522009959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009961 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 507522009962 putative substrate binding pocket [chemical binding]; other site 507522009963 putative dimerization interface [polypeptide binding]; other site 507522009964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522009965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522009966 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522009967 putative effector binding pocket; other site 507522009968 putative dimerization interface [polypeptide binding]; other site 507522009969 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 507522009970 NmrA-like family; Region: NmrA; pfam05368 507522009971 NAD(P) binding site [chemical binding]; other site 507522009972 active site lysine 507522009973 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522009974 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 507522009975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522009976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522009977 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 507522009978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522009979 NAD(P) binding site [chemical binding]; other site 507522009980 active site 507522009981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522009982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522009983 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 507522009984 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 507522009985 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 507522009986 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 507522009987 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 507522009988 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 507522009989 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 507522009990 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 507522009991 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 507522009992 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 507522009993 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 507522009994 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 507522009995 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 507522009996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522009997 Walker A motif; other site 507522009998 ATP binding site [chemical binding]; other site 507522009999 Walker B motif; other site 507522010000 arginine finger; other site 507522010001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522010002 Walker A motif; other site 507522010003 ATP binding site [chemical binding]; other site 507522010004 Walker B motif; other site 507522010005 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 507522010006 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 507522010007 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 507522010008 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522010009 ligand binding site [chemical binding]; other site 507522010010 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 507522010011 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 507522010012 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 507522010013 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 507522010014 Protein of unknown function (DUF877); Region: DUF877; pfam05943 507522010015 Protein of unknown function (DUF770); Region: DUF770; pfam05591 507522010016 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 507522010017 intracellular protease, PfpI family; Region: PfpI; TIGR01382 507522010018 conserved cys residue [active] 507522010019 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 507522010020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522010021 NAD(P) binding site [chemical binding]; other site 507522010022 active site 507522010023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010025 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522010026 putative effector binding pocket; other site 507522010027 putative dimerization interface [polypeptide binding]; other site 507522010028 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 507522010029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 507522010030 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 507522010031 anti sigma factor interaction site; other site 507522010032 regulatory phosphorylation site [posttranslational modification]; other site 507522010033 Response regulator receiver domain; Region: Response_reg; pfam00072 507522010034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522010035 active site 507522010036 phosphorylation site [posttranslational modification] 507522010037 intermolecular recognition site; other site 507522010038 dimerization interface [polypeptide binding]; other site 507522010039 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 507522010040 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 507522010041 OpgC protein; Region: OpgC_C; cl17858 507522010042 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 507522010043 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 507522010044 DXD motif; other site 507522010045 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 507522010046 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 507522010047 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 507522010048 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 507522010049 heme-binding site [chemical binding]; other site 507522010050 PAS fold; Region: PAS_7; pfam12860 507522010051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522010052 PAS fold; Region: PAS_3; pfam08447 507522010053 putative active site [active] 507522010054 heme pocket [chemical binding]; other site 507522010055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 507522010056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522010057 dimer interface [polypeptide binding]; other site 507522010058 phosphorylation site [posttranslational modification] 507522010059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522010060 ATP binding site [chemical binding]; other site 507522010061 Mg2+ binding site [ion binding]; other site 507522010062 G-X-G motif; other site 507522010063 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 507522010064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522010065 active site 507522010066 phosphorylation site [posttranslational modification] 507522010067 intermolecular recognition site; other site 507522010068 dimerization interface [polypeptide binding]; other site 507522010069 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 507522010070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522010071 active site 507522010072 phosphorylation site [posttranslational modification] 507522010073 intermolecular recognition site; other site 507522010074 dimerization interface [polypeptide binding]; other site 507522010075 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 507522010076 putative binding surface; other site 507522010077 active site 507522010078 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 507522010079 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 507522010080 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 507522010081 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522010082 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522010083 active site 507522010084 catalytic tetrad [active] 507522010085 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522010086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010087 putative substrate translocation pore; other site 507522010088 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 507522010089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010091 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 507522010092 putative effector binding pocket; other site 507522010093 putative dimerization interface [polypeptide binding]; other site 507522010094 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 507522010095 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 507522010096 catalytic residues [active] 507522010097 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522010098 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522010099 Walker A/P-loop; other site 507522010100 ATP binding site [chemical binding]; other site 507522010101 Q-loop/lid; other site 507522010102 ABC transporter signature motif; other site 507522010103 Walker B; other site 507522010104 D-loop; other site 507522010105 H-loop/switch region; other site 507522010106 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522010107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010108 dimer interface [polypeptide binding]; other site 507522010109 conserved gate region; other site 507522010110 putative PBP binding loops; other site 507522010111 ABC-ATPase subunit interface; other site 507522010112 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522010113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010114 dimer interface [polypeptide binding]; other site 507522010115 conserved gate region; other site 507522010116 putative PBP binding loops; other site 507522010117 ABC-ATPase subunit interface; other site 507522010118 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 507522010119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522010120 membrane-bound complex binding site; other site 507522010121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522010124 dimerization interface [polypeptide binding]; other site 507522010125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522010128 dimerization interface [polypeptide binding]; other site 507522010129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522010130 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522010131 substrate binding pocket [chemical binding]; other site 507522010132 membrane-bound complex binding site; other site 507522010133 hinge residues; other site 507522010134 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522010135 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522010136 Walker A/P-loop; other site 507522010137 ATP binding site [chemical binding]; other site 507522010138 Q-loop/lid; other site 507522010139 ABC transporter signature motif; other site 507522010140 Walker B; other site 507522010141 D-loop; other site 507522010142 H-loop/switch region; other site 507522010143 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522010144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010145 dimer interface [polypeptide binding]; other site 507522010146 conserved gate region; other site 507522010147 putative PBP binding loops; other site 507522010148 ABC-ATPase subunit interface; other site 507522010149 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 507522010150 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 507522010151 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 507522010152 peptide binding site [polypeptide binding]; other site 507522010153 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 507522010154 putative active site [active] 507522010155 Zn binding site [ion binding]; other site 507522010156 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 507522010157 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 507522010158 active site 507522010159 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 507522010160 dimer interface [polypeptide binding]; other site 507522010161 catalytic triad [active] 507522010162 peroxidatic and resolving cysteines [active] 507522010163 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 507522010164 Putative ammonia monooxygenase; Region: AmoA; pfam05145 507522010165 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 507522010166 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 507522010167 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 507522010168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522010169 putative active site [active] 507522010170 heme pocket [chemical binding]; other site 507522010171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522010172 Walker A motif; other site 507522010173 ATP binding site [chemical binding]; other site 507522010174 Walker B motif; other site 507522010175 arginine finger; other site 507522010176 hypothetical protein; Provisional; Region: PRK05415 507522010177 Domain of unknown function (DUF697); Region: DUF697; cl12064 507522010178 Predicted ATPase [General function prediction only]; Region: COG3106 507522010179 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 507522010180 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 507522010181 phage shock protein C; Region: phageshock_pspC; TIGR02978 507522010182 phage shock protein B; Provisional; Region: pspB; PRK09458 507522010183 phage shock protein PspA; Provisional; Region: PRK10698 507522010184 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 507522010185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522010186 Walker A motif; other site 507522010187 ATP binding site [chemical binding]; other site 507522010188 Walker B motif; other site 507522010189 arginine finger; other site 507522010190 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522010191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522010192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010193 putative substrate translocation pore; other site 507522010194 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522010195 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 507522010196 metal binding site [ion binding]; metal-binding site 507522010197 putative dimer interface [polypeptide binding]; other site 507522010198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522010199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522010200 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 507522010201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522010202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522010203 salt bridge; other site 507522010204 non-specific DNA binding site [nucleotide binding]; other site 507522010205 sequence-specific DNA binding site [nucleotide binding]; other site 507522010206 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 507522010207 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 507522010208 putative NAD(P) binding site [chemical binding]; other site 507522010209 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 507522010210 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 507522010211 peptide binding site [polypeptide binding]; other site 507522010212 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 507522010213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010214 dimer interface [polypeptide binding]; other site 507522010215 conserved gate region; other site 507522010216 putative PBP binding loops; other site 507522010217 ABC-ATPase subunit interface; other site 507522010218 hypothetical protein; Provisional; Region: PRK09951 507522010219 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 507522010220 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 507522010221 active site 507522010222 DNA binding site [nucleotide binding] 507522010223 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 507522010224 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 507522010225 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 507522010226 Catalytic site [active] 507522010227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522010228 active site 507522010229 Int/Topo IB signature motif; other site 507522010230 DNA binding site [nucleotide binding] 507522010231 SurA N-terminal domain; Region: SurA_N_3; cl07813 507522010232 RecT family; Region: RecT; pfam03837 507522010233 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 507522010234 integrase; Provisional; Region: PRK09692 507522010235 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522010236 active site 507522010237 Int/Topo IB signature motif; other site 507522010238 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 507522010239 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522010240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010241 dimer interface [polypeptide binding]; other site 507522010242 conserved gate region; other site 507522010243 putative PBP binding loops; other site 507522010244 ABC-ATPase subunit interface; other site 507522010245 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 507522010246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522010247 Walker A/P-loop; other site 507522010248 ATP binding site [chemical binding]; other site 507522010249 Q-loop/lid; other site 507522010250 ABC transporter signature motif; other site 507522010251 Walker B; other site 507522010252 D-loop; other site 507522010253 H-loop/switch region; other site 507522010254 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522010255 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 507522010256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522010257 Walker A/P-loop; other site 507522010258 ATP binding site [chemical binding]; other site 507522010259 Q-loop/lid; other site 507522010260 ABC transporter signature motif; other site 507522010261 Walker B; other site 507522010262 D-loop; other site 507522010263 H-loop/switch region; other site 507522010264 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 507522010265 active sites [active] 507522010266 tetramer interface [polypeptide binding]; other site 507522010267 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 507522010268 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522010269 Walker A/P-loop; other site 507522010270 ATP binding site [chemical binding]; other site 507522010271 Q-loop/lid; other site 507522010272 ABC transporter signature motif; other site 507522010273 Walker B; other site 507522010274 D-loop; other site 507522010275 H-loop/switch region; other site 507522010276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522010278 dimer interface [polypeptide binding]; other site 507522010279 conserved gate region; other site 507522010280 putative PBP binding loops; other site 507522010281 ABC-ATPase subunit interface; other site 507522010282 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522010283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010284 dimer interface [polypeptide binding]; other site 507522010285 conserved gate region; other site 507522010286 putative PBP binding loops; other site 507522010287 ABC-ATPase subunit interface; other site 507522010288 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 507522010289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522010290 substrate binding pocket [chemical binding]; other site 507522010291 membrane-bound complex binding site; other site 507522010292 hinge residues; other site 507522010293 HutD; Region: HutD; pfam05962 507522010294 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 507522010295 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 507522010296 NAD binding site [chemical binding]; other site 507522010297 homotetramer interface [polypeptide binding]; other site 507522010298 homodimer interface [polypeptide binding]; other site 507522010299 substrate binding site [chemical binding]; other site 507522010300 active site 507522010301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 507522010302 Uncharacterized conserved protein [Function unknown]; Region: COG2128 507522010303 exoribonuclease II; Provisional; Region: PRK05054 507522010304 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 507522010305 RNB domain; Region: RNB; pfam00773 507522010306 S1 RNA binding domain; Region: S1; pfam00575 507522010307 hypothetical protein; Provisional; Region: PRK13658 507522010308 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 507522010309 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 507522010310 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522010311 lipoprotein; Provisional; Region: PRK10540 507522010312 translation initiation factor Sui1; Validated; Region: PRK06824 507522010313 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 507522010314 putative rRNA binding site [nucleotide binding]; other site 507522010315 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 507522010316 active site 507522010317 dimer interface [polypeptide binding]; other site 507522010318 tetratricopeptide repeat protein; Provisional; Region: PRK11788 507522010319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 507522010320 TPR motif; other site 507522010321 binding surface 507522010322 Predicted membrane protein [Function unknown]; Region: COG3771 507522010323 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 507522010324 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 507522010325 active site 507522010326 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 507522010327 dimerization interface [polypeptide binding]; other site 507522010328 active site 507522010329 aconitate hydratase; Validated; Region: PRK09277 507522010330 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 507522010331 substrate binding site [chemical binding]; other site 507522010332 ligand binding site [chemical binding]; other site 507522010333 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 507522010334 substrate binding site [chemical binding]; other site 507522010335 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 507522010336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010337 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 507522010338 substrate binding site [chemical binding]; other site 507522010339 putative dimerization interface [polypeptide binding]; other site 507522010340 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 507522010341 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 507522010342 active site 507522010343 interdomain interaction site; other site 507522010344 putative metal-binding site [ion binding]; other site 507522010345 nucleotide binding site [chemical binding]; other site 507522010346 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 507522010347 domain I; other site 507522010348 DNA binding groove [nucleotide binding] 507522010349 phosphate binding site [ion binding]; other site 507522010350 domain II; other site 507522010351 domain III; other site 507522010352 nucleotide binding site [chemical binding]; other site 507522010353 catalytic site [active] 507522010354 domain IV; other site 507522010355 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 507522010356 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 507522010357 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 507522010358 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 507522010359 hypothetical protein; Provisional; Region: PRK11037 507522010360 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 507522010361 putative inner membrane peptidase; Provisional; Region: PRK11778 507522010362 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 507522010363 tandem repeat interface [polypeptide binding]; other site 507522010364 oligomer interface [polypeptide binding]; other site 507522010365 active site residues [active] 507522010366 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 507522010367 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 507522010368 NADP binding site [chemical binding]; other site 507522010369 homodimer interface [polypeptide binding]; other site 507522010370 active site 507522010371 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 507522010372 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 507522010373 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 507522010374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522010375 RNA binding surface [nucleotide binding]; other site 507522010376 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 507522010377 probable active site [active] 507522010378 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 507522010379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010380 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522010381 dimerization interface [polypeptide binding]; other site 507522010382 substrate binding pocket [chemical binding]; other site 507522010383 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522010384 EamA-like transporter family; Region: EamA; pfam00892 507522010385 hypothetical protein; Provisional; Region: PRK11630 507522010386 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 507522010387 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 507522010388 active site 507522010389 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 507522010390 anthranilate synthase component I; Provisional; Region: PRK13564 507522010391 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 507522010392 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 507522010393 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 507522010394 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 507522010395 glutamine binding [chemical binding]; other site 507522010396 catalytic triad [active] 507522010397 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 507522010398 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 507522010399 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 507522010400 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 507522010401 active site 507522010402 ribulose/triose binding site [chemical binding]; other site 507522010403 phosphate binding site [ion binding]; other site 507522010404 substrate (anthranilate) binding pocket [chemical binding]; other site 507522010405 product (indole) binding pocket [chemical binding]; other site 507522010406 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 507522010407 active site 507522010408 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 507522010409 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 507522010410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522010411 catalytic residue [active] 507522010412 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 507522010413 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 507522010414 substrate binding site [chemical binding]; other site 507522010415 active site 507522010416 catalytic residues [active] 507522010417 heterodimer interface [polypeptide binding]; other site 507522010418 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 507522010419 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 507522010420 MOFRL family; Region: MOFRL; pfam05161 507522010421 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 507522010422 tartrate dehydrogenase; Region: TTC; TIGR02089 507522010423 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 507522010424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010425 putative substrate translocation pore; other site 507522010426 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 507522010427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010428 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 507522010429 dimerization interface [polypeptide binding]; other site 507522010430 substrate binding pocket [chemical binding]; other site 507522010431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522010432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522010433 putative DNA binding site [nucleotide binding]; other site 507522010434 putative Zn2+ binding site [ion binding]; other site 507522010435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 507522010436 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 507522010437 putative NAD(P) binding site [chemical binding]; other site 507522010438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522010439 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 507522010440 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522010441 N-terminal plug; other site 507522010442 ligand-binding site [chemical binding]; other site 507522010443 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 507522010444 outer membrane protein W; Provisional; Region: PRK10959 507522010445 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 507522010446 hypothetical protein; Provisional; Region: PRK02868 507522010447 intracellular septation protein A; Reviewed; Region: PRK00259 507522010448 outer membrane receptor FepA; Provisional; Region: PRK13528 507522010449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522010450 N-terminal plug; other site 507522010451 ligand-binding site [chemical binding]; other site 507522010452 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 507522010453 YniB-like protein; Region: YniB; pfam14002 507522010454 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 507522010455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522010456 motif II; other site 507522010457 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 507522010458 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 507522010459 NADP binding site [chemical binding]; other site 507522010460 homodimer interface [polypeptide binding]; other site 507522010461 active site 507522010462 inner membrane protein; Provisional; Region: PRK11648 507522010463 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 507522010464 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 507522010465 cell division modulator; Provisional; Region: PRK10113 507522010466 hydroperoxidase II; Provisional; Region: katE; PRK11249 507522010467 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 507522010468 tetramer interface [polypeptide binding]; other site 507522010469 heme binding pocket [chemical binding]; other site 507522010470 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 507522010471 domain interactions; other site 507522010472 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 507522010473 putative active site [active] 507522010474 YdjC motif; other site 507522010475 Mg binding site [ion binding]; other site 507522010476 putative homodimer interface [polypeptide binding]; other site 507522010477 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 507522010478 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 507522010479 NAD binding site [chemical binding]; other site 507522010480 sugar binding site [chemical binding]; other site 507522010481 divalent metal binding site [ion binding]; other site 507522010482 tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522010483 dimer interface [polypeptide binding]; other site 507522010484 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 507522010485 Cupin domain; Region: Cupin_2; pfam07883 507522010486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522010487 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 507522010488 methionine cluster; other site 507522010489 active site 507522010490 phosphorylation site [posttranslational modification] 507522010491 metal binding site [ion binding]; metal-binding site 507522010492 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 507522010493 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522010494 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522010495 active site 507522010496 P-loop; other site 507522010497 phosphorylation site [posttranslational modification] 507522010498 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 507522010499 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 507522010500 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 507522010501 homodimer interface [polypeptide binding]; other site 507522010502 NAD binding pocket [chemical binding]; other site 507522010503 ATP binding pocket [chemical binding]; other site 507522010504 Mg binding site [ion binding]; other site 507522010505 active-site loop [active] 507522010506 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 507522010507 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 507522010508 GIY-YIG motif/motif A; other site 507522010509 active site 507522010510 catalytic site [active] 507522010511 putative DNA binding site [nucleotide binding]; other site 507522010512 metal binding site [ion binding]; metal-binding site 507522010513 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 507522010514 dimer interface [polypeptide binding]; other site 507522010515 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 507522010516 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 507522010517 putative active site [active] 507522010518 Zn binding site [ion binding]; other site 507522010519 succinylarginine dihydrolase; Provisional; Region: PRK13281 507522010520 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 507522010521 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 507522010522 NAD(P) binding site [chemical binding]; other site 507522010523 catalytic residues [active] 507522010524 arginine succinyltransferase; Provisional; Region: PRK10456 507522010525 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 507522010526 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 507522010527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522010528 inhibitor-cofactor binding pocket; inhibition site 507522010529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522010530 catalytic residue [active] 507522010531 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 507522010532 putative catalytic site [active] 507522010533 putative phosphate binding site [ion binding]; other site 507522010534 active site 507522010535 metal binding site A [ion binding]; metal-binding site 507522010536 DNA binding site [nucleotide binding] 507522010537 putative AP binding site [nucleotide binding]; other site 507522010538 putative metal binding site B [ion binding]; other site 507522010539 Uncharacterized conserved protein [Function unknown]; Region: COG0398 507522010540 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522010541 Uncharacterized conserved protein [Function unknown]; Region: COG0398 507522010542 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522010543 Uncharacterized conserved protein [Function unknown]; Region: COG2128 507522010544 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 507522010545 hypothetical protein; Provisional; Region: PRK11622 507522010546 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 507522010547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010548 ABC-ATPase subunit interface; other site 507522010549 putative PBP binding loops; other site 507522010550 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 507522010551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522010552 Walker A/P-loop; other site 507522010553 ATP binding site [chemical binding]; other site 507522010554 Q-loop/lid; other site 507522010555 ABC transporter signature motif; other site 507522010556 Walker B; other site 507522010557 D-loop; other site 507522010558 H-loop/switch region; other site 507522010559 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 507522010560 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 507522010561 active site residue [active] 507522010562 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 507522010563 active site residue [active] 507522010564 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 507522010565 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 507522010566 active site 507522010567 8-oxo-dGMP binding site [chemical binding]; other site 507522010568 nudix motif; other site 507522010569 metal binding site [ion binding]; metal-binding site 507522010570 glutamate dehydrogenase; Provisional; Region: PRK09414 507522010571 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 507522010572 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 507522010573 NAD(P) binding site [chemical binding]; other site 507522010574 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 507522010575 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 507522010576 NAD(P) binding site [chemical binding]; other site 507522010577 DNA topoisomerase III; Provisional; Region: PRK07726 507522010578 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 507522010579 active site 507522010580 putative interdomain interaction site [polypeptide binding]; other site 507522010581 putative metal-binding site [ion binding]; other site 507522010582 putative nucleotide binding site [chemical binding]; other site 507522010583 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 507522010584 domain I; other site 507522010585 DNA binding groove [nucleotide binding] 507522010586 phosphate binding site [ion binding]; other site 507522010587 domain II; other site 507522010588 domain III; other site 507522010589 nucleotide binding site [chemical binding]; other site 507522010590 catalytic site [active] 507522010591 domain IV; other site 507522010592 selenophosphate synthetase; Provisional; Region: PRK00943 507522010593 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 507522010594 dimerization interface [polypeptide binding]; other site 507522010595 putative ATP binding site [chemical binding]; other site 507522010596 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 507522010597 active site 507522010598 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 507522010599 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 507522010600 putative FMN binding site [chemical binding]; other site 507522010601 protease 4; Provisional; Region: PRK10949 507522010602 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 507522010603 tandem repeat interface [polypeptide binding]; other site 507522010604 oligomer interface [polypeptide binding]; other site 507522010605 active site residues [active] 507522010606 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 507522010607 tandem repeat interface [polypeptide binding]; other site 507522010608 oligomer interface [polypeptide binding]; other site 507522010609 active site residues [active] 507522010610 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 507522010611 active site 507522010612 homodimer interface [polypeptide binding]; other site 507522010613 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 507522010614 Isochorismatase family; Region: Isochorismatase; pfam00857 507522010615 catalytic triad [active] 507522010616 metal binding site [ion binding]; metal-binding site 507522010617 conserved cis-peptide bond; other site 507522010618 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 507522010619 active site 507522010620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 507522010621 methionine sulfoxide reductase B; Provisional; Region: PRK00222 507522010622 SelR domain; Region: SelR; pfam01641 507522010623 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 507522010624 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 507522010625 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 507522010626 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 507522010627 active site 507522010628 phosphate binding residues; other site 507522010629 catalytic residues [active] 507522010630 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522010631 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522010632 active site 507522010633 catalytic tetrad [active] 507522010634 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 507522010635 PrkA family serine protein kinase; Provisional; Region: PRK15455 507522010636 AAA ATPase domain; Region: AAA_16; pfam13191 507522010637 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 507522010638 Walker A motif; other site 507522010639 ATP binding site [chemical binding]; other site 507522010640 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 507522010641 hypothetical protein; Provisional; Region: PRK05325 507522010642 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 507522010643 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 507522010644 catalytic residues [active] 507522010645 dimer interface [polypeptide binding]; other site 507522010646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010648 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522010649 dimerization interface [polypeptide binding]; other site 507522010650 putative effector binding pocket; other site 507522010651 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 507522010652 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 507522010653 NAD(P) binding site [chemical binding]; other site 507522010654 active site 507522010655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522010658 dimerization interface [polypeptide binding]; other site 507522010659 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522010660 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 507522010661 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 507522010662 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 507522010663 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522010664 Walker A/P-loop; other site 507522010665 ATP binding site [chemical binding]; other site 507522010666 Q-loop/lid; other site 507522010667 ABC transporter signature motif; other site 507522010668 Walker B; other site 507522010669 D-loop; other site 507522010670 H-loop/switch region; other site 507522010671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010672 dimer interface [polypeptide binding]; other site 507522010673 conserved gate region; other site 507522010674 putative PBP binding loops; other site 507522010675 ABC-ATPase subunit interface; other site 507522010676 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 507522010677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522010678 substrate binding pocket [chemical binding]; other site 507522010679 membrane-bound complex binding site; other site 507522010680 hinge residues; other site 507522010681 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 507522010682 hypothetical protein; Provisional; Region: PRK07483 507522010683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522010684 inhibitor-cofactor binding pocket; inhibition site 507522010685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522010686 catalytic residue [active] 507522010687 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522010688 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522010689 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522010690 putative active site [active] 507522010691 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 507522010692 Helix-turn-helix domain; Region: HTH_18; pfam12833 507522010693 short chain dehydrogenase; Validated; Region: PRK06182 507522010694 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 507522010695 NADP binding site [chemical binding]; other site 507522010696 active site 507522010697 steroid binding site; other site 507522010698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010700 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522010701 putative effector binding pocket; other site 507522010702 dimerization interface [polypeptide binding]; other site 507522010703 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522010704 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 507522010705 FMN binding site [chemical binding]; other site 507522010706 active site 507522010707 substrate binding site [chemical binding]; other site 507522010708 catalytic residue [active] 507522010709 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 507522010710 short chain dehydrogenase; Provisional; Region: PRK06500 507522010711 classical (c) SDRs; Region: SDR_c; cd05233 507522010712 NAD(P) binding site [chemical binding]; other site 507522010713 active site 507522010714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522010715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010716 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 507522010717 putative effector binding pocket; other site 507522010718 putative dimerization interface [polypeptide binding]; other site 507522010719 magnesium-transporting ATPase; Provisional; Region: PRK15122 507522010720 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 507522010721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522010722 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 507522010723 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 507522010724 Soluble P-type ATPase [General function prediction only]; Region: COG4087 507522010725 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 507522010726 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 507522010727 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 507522010728 PhoU domain; Region: PhoU; pfam01895 507522010729 PhoU domain; Region: PhoU; pfam01895 507522010730 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 507522010731 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 507522010732 hypothetical protein; Provisional; Region: PRK07236 507522010733 tetracycline repressor protein TetR; Provisional; Region: PRK13756 507522010734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522010735 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 507522010736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522010738 putative substrate translocation pore; other site 507522010739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522010741 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 507522010742 putative NAD(P) binding site [chemical binding]; other site 507522010743 putative active site [active] 507522010744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522010745 DNA-binding site [nucleotide binding]; DNA binding site 507522010746 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522010747 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522010748 FCD domain; Region: FCD; pfam07729 507522010749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522010750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522010751 substrate binding pocket [chemical binding]; other site 507522010752 membrane-bound complex binding site; other site 507522010753 hinge residues; other site 507522010754 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522010755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522010756 dimer interface [polypeptide binding]; other site 507522010757 conserved gate region; other site 507522010758 putative PBP binding loops; other site 507522010759 ABC-ATPase subunit interface; other site 507522010760 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522010761 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522010762 Walker A/P-loop; other site 507522010763 ATP binding site [chemical binding]; other site 507522010764 Q-loop/lid; other site 507522010765 ABC transporter signature motif; other site 507522010766 Walker B; other site 507522010767 D-loop; other site 507522010768 H-loop/switch region; other site 507522010769 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 507522010770 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 507522010771 metal binding site [ion binding]; metal-binding site 507522010772 dimer interface [polypeptide binding]; other site 507522010773 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 507522010774 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 507522010775 metal binding site [ion binding]; metal-binding site 507522010776 substrate binding pocket [chemical binding]; other site 507522010777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 507522010778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 507522010779 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 507522010780 active site 507522010781 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 507522010782 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 507522010783 inhibitor site; inhibition site 507522010784 active site 507522010785 dimer interface [polypeptide binding]; other site 507522010786 catalytic residue [active] 507522010787 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 507522010788 Glutamine amidotransferase class-I; Region: GATase; pfam00117 507522010789 conserved cys residue [active] 507522010790 aspartate aminotransferase; Provisional; Region: PRK05764 507522010791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522010792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522010793 homodimer interface [polypeptide binding]; other site 507522010794 catalytic residue [active] 507522010795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522010796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522010797 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 507522010798 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 507522010799 conserved cys residue [active] 507522010800 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 507522010801 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 507522010802 Catalytic site [active] 507522010803 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 507522010804 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 507522010805 active site 507522010806 DNA binding site [nucleotide binding] 507522010807 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 507522010808 DinI-like family; Region: DinI; cl11630 507522010809 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 507522010810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 507522010811 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 507522010812 putative deacylase active site [active] 507522010813 Predicted membrane protein [Function unknown]; Region: COG2707 507522010814 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522010815 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 507522010816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522010817 hypothetical protein; Validated; Region: PRK06186 507522010818 conserved cys residue [active] 507522010819 Uncharacterized conserved protein [Function unknown]; Region: COG1683 507522010820 Uncharacterized conserved protein [Function unknown]; Region: COG3189 507522010821 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 507522010822 Domain of unknown function (DUF333); Region: DUF333; pfam03891 507522010823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 507522010824 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 507522010825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522010826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522010827 metal binding site [ion binding]; metal-binding site 507522010828 active site 507522010829 I-site; other site 507522010830 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 507522010831 leucine export protein LeuE; Provisional; Region: PRK10958 507522010832 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 507522010833 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 507522010834 putative acyl-acceptor binding pocket; other site 507522010835 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 507522010836 active site 507522010837 homotetramer interface [polypeptide binding]; other site 507522010838 homodimer interface [polypeptide binding]; other site 507522010839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522010840 Zn2+ binding site [ion binding]; other site 507522010841 Mg2+ binding site [ion binding]; other site 507522010842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522010843 Zn2+ binding site [ion binding]; other site 507522010844 Mg2+ binding site [ion binding]; other site 507522010845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522010846 dimerization interface [polypeptide binding]; other site 507522010847 GAF domain; Region: GAF; cl17456 507522010848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522010849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522010850 metal binding site [ion binding]; metal-binding site 507522010851 active site 507522010852 I-site; other site 507522010853 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 507522010854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522010855 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 507522010856 dimerization interface [polypeptide binding]; other site 507522010857 substrate binding pocket [chemical binding]; other site 507522010858 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 507522010859 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 507522010860 dimer interface [polypeptide binding]; other site 507522010861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522010862 Helix-turn-helix domain; Region: HTH_39; pfam14090 507522010863 Cupin domain; Region: Cupin_2; cl17218 507522010864 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522010865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522010866 Fusaric acid resistance protein family; Region: FUSC; pfam04632 507522010867 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522010868 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 507522010869 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522010870 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522010871 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 507522010872 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 507522010873 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 507522010874 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 507522010875 dimanganese center [ion binding]; other site 507522010876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 507522010877 dinuclear metal binding motif [ion binding]; other site 507522010878 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 507522010879 dimerization interface [polypeptide binding]; other site 507522010880 metal binding site [ion binding]; metal-binding site 507522010881 General stress protein [General function prediction only]; Region: GsiB; COG3729 507522010882 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 507522010883 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 507522010884 NAD binding site [chemical binding]; other site 507522010885 catalytic Zn binding site [ion binding]; other site 507522010886 structural Zn binding site [ion binding]; other site 507522010887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 507522010888 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 507522010889 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 507522010890 Isochorismatase family; Region: Isochorismatase; pfam00857 507522010891 catalytic triad [active] 507522010892 conserved cis-peptide bond; other site 507522010893 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 507522010894 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 507522010895 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 507522010896 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 507522010897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522010898 dimerization interface [polypeptide binding]; other site 507522010899 putative DNA binding site [nucleotide binding]; other site 507522010900 putative Zn2+ binding site [ion binding]; other site 507522010901 PHAGE01; KPK_5612 507522010902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 507522010903 MASE2 domain; Region: MASE2; pfam05230 507522010904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522010905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522010906 metal binding site [ion binding]; metal-binding site 507522010907 active site 507522010908 I-site; other site 507522010909 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 507522010910 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 507522010911 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 507522010912 MPN+ (JAMM) motif; other site 507522010913 Zinc-binding site [ion binding]; other site 507522010914 NlpC/P60 family; Region: NLPC_P60; pfam00877 507522010915 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 507522010916 Phage-related protein [Function unknown]; Region: gp18; COG4672 507522010917 Phage minor tail protein; Region: Phage_min_tail; pfam05939 507522010918 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 507522010919 Phage capsid family; Region: Phage_capsid; pfam05065 507522010920 Phage portal protein; Region: Phage_portal; pfam04860 507522010921 Phage-related protein [Function unknown]; Region: COG4695 507522010922 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 507522010923 Phage terminase, small subunit; Region: Terminase_4; pfam05119 507522010924 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 507522010925 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 507522010926 active site 507522010927 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 507522010928 catalytic residues [active] 507522010929 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 507522010930 Fumble; Region: Fumble; cl17357 507522010931 YcfA-like protein; Region: YcfA; pfam07927 507522010932 Uncharacterized conserved protein [Function unknown]; Region: COG1479 507522010933 Protein of unknown function DUF262; Region: DUF262; pfam03235 507522010934 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 507522010935 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 507522010936 cofactor binding site; other site 507522010937 DNA binding site [nucleotide binding] 507522010938 substrate interaction site [chemical binding]; other site 507522010939 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 507522010940 Protein of unknown function (DUF968); Region: DUF968; pfam06147 507522010941 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 507522010942 DinI-like family; Region: DinI; cl11630 507522010943 Predicted transcriptional regulator [Transcription]; Region: COG2378 507522010944 HTH domain; Region: HTH_11; pfam08279 507522010945 WYL domain; Region: WYL; pfam13280 507522010946 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522010947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522010948 NAD(P) binding site [chemical binding]; other site 507522010949 active site 507522010950 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 507522010951 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 507522010952 GAF domain; Region: GAF; pfam01590 507522010953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522010954 PerC transcriptional activator; Region: PerC; pfam06069 507522010955 Replication protein P; Region: Phage_lambda_P; pfam06992 507522010956 primosomal protein DnaI; Provisional; Region: PRK02854 507522010957 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 507522010958 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 507522010959 transcriptional repressor DicA; Reviewed; Region: PRK09706 507522010960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522010961 salt bridge; other site 507522010962 non-specific DNA binding site [nucleotide binding]; other site 507522010963 sequence-specific DNA binding site [nucleotide binding]; other site 507522010964 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 507522010965 Predicted transcriptional regulator [Transcription]; Region: COG1959 507522010966 Transcriptional regulator; Region: Rrf2; cl17282 507522010967 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 507522010968 Excisionase-like protein; Region: Exc; pfam07825 507522010969 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 507522010970 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 507522010971 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522010972 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 507522010973 dimer interface [polypeptide binding]; other site 507522010974 active site 507522010975 Int/Topo IB signature motif; other site 507522010976 isocitrate dehydrogenase; Validated; Region: PRK07362 507522010977 isocitrate dehydrogenase; Reviewed; Region: PRK07006 507522010978 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 507522010979 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 507522010980 probable active site [active] 507522010981 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 507522010982 nudix motif; other site 507522010983 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 507522010984 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 507522010985 putative lysogenization regulator; Reviewed; Region: PRK00218 507522010986 adenylosuccinate lyase; Provisional; Region: PRK09285 507522010987 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 507522010988 tetramer interface [polypeptide binding]; other site 507522010989 active site 507522010990 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 507522010991 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522010992 Helix-turn-helix domain; Region: HTH_18; pfam12833 507522010993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522010994 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 507522010995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522010996 active site 507522010997 phosphorylation site [posttranslational modification] 507522010998 intermolecular recognition site; other site 507522010999 dimerization interface [polypeptide binding]; other site 507522011000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522011001 DNA binding site [nucleotide binding] 507522011002 sensor protein PhoQ; Provisional; Region: PRK10815 507522011003 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 507522011004 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 507522011005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522011006 ATP binding site [chemical binding]; other site 507522011007 Mg2+ binding site [ion binding]; other site 507522011008 G-X-G motif; other site 507522011009 Uncharacterized conserved protein [Function unknown]; Region: COG2850 507522011010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 507522011011 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 507522011012 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 507522011013 metal binding site [ion binding]; metal-binding site 507522011014 dimer interface [polypeptide binding]; other site 507522011015 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 507522011016 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 507522011017 Walker A/P-loop; other site 507522011018 ATP binding site [chemical binding]; other site 507522011019 Q-loop/lid; other site 507522011020 ABC transporter signature motif; other site 507522011021 Walker B; other site 507522011022 D-loop; other site 507522011023 H-loop/switch region; other site 507522011024 TOBE domain; Region: TOBE_2; pfam08402 507522011025 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522011026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011027 dimer interface [polypeptide binding]; other site 507522011028 conserved gate region; other site 507522011029 putative PBP binding loops; other site 507522011030 ABC-ATPase subunit interface; other site 507522011031 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522011032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011033 dimer interface [polypeptide binding]; other site 507522011034 conserved gate region; other site 507522011035 putative PBP binding loops; other site 507522011036 ABC-ATPase subunit interface; other site 507522011037 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 507522011038 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 507522011039 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 507522011040 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 507522011041 NAD(P) binding site [chemical binding]; other site 507522011042 catalytic residues [active] 507522011043 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 507522011044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 507522011045 acyl-activating enzyme (AAE) consensus motif; other site 507522011046 AMP binding site [chemical binding]; other site 507522011047 active site 507522011048 CoA binding site [chemical binding]; other site 507522011049 transketolase; Reviewed; Region: PRK12753 507522011050 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522011051 TPP-binding site [chemical binding]; other site 507522011052 dimer interface [polypeptide binding]; other site 507522011053 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522011054 PYR/PP interface [polypeptide binding]; other site 507522011055 dimer interface [polypeptide binding]; other site 507522011056 TPP binding site [chemical binding]; other site 507522011057 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522011058 transaldolase-like protein; Provisional; Region: PTZ00411 507522011059 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 507522011060 active site 507522011061 dimer interface [polypeptide binding]; other site 507522011062 catalytic residue [active] 507522011063 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 507522011064 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 507522011065 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 507522011066 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 507522011067 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 507522011068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 507522011069 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 507522011070 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 507522011071 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 507522011072 substrate binding site [chemical binding]; other site 507522011073 dimer interface [polypeptide binding]; other site 507522011074 triosephosphate isomerase; Provisional; Region: PRK14565 507522011075 catalytic triad [active] 507522011076 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 507522011077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 507522011078 DNA binding residues [nucleotide binding] 507522011079 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 507522011080 NAD-dependent deacetylase; Provisional; Region: PRK00481 507522011081 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 507522011082 NAD+ binding site [chemical binding]; other site 507522011083 substrate binding site [chemical binding]; other site 507522011084 Zn binding site [ion binding]; other site 507522011085 fructokinase; Reviewed; Region: PRK09557 507522011086 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522011087 nucleotide binding site [chemical binding]; other site 507522011088 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 507522011089 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 507522011090 FtsX-like permease family; Region: FtsX; pfam02687 507522011091 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 507522011092 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 507522011093 Walker A/P-loop; other site 507522011094 ATP binding site [chemical binding]; other site 507522011095 Q-loop/lid; other site 507522011096 ABC transporter signature motif; other site 507522011097 Walker B; other site 507522011098 D-loop; other site 507522011099 H-loop/switch region; other site 507522011100 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 507522011101 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 507522011102 FtsX-like permease family; Region: FtsX; pfam02687 507522011103 transcription-repair coupling factor; Provisional; Region: PRK10689 507522011104 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 507522011105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522011106 ATP binding site [chemical binding]; other site 507522011107 putative Mg++ binding site [ion binding]; other site 507522011108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522011109 nucleotide binding region [chemical binding]; other site 507522011110 ATP-binding site [chemical binding]; other site 507522011111 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 507522011112 L,D-transpeptidase; Provisional; Region: PRK10190 507522011113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522011114 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522011115 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522011116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522011117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522011118 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 507522011119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522011120 N-terminal plug; other site 507522011121 ligand-binding site [chemical binding]; other site 507522011122 hypothetical protein; Provisional; Region: PRK11280 507522011123 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 507522011124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522011125 hypothetical protein; Provisional; Region: PRK04940 507522011126 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 507522011127 beta-hexosaminidase; Provisional; Region: PRK05337 507522011128 thiamine kinase; Region: ycfN_thiK; TIGR02721 507522011129 thiamine kinase; Provisional; Region: thiK; PRK10271 507522011130 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 507522011131 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 507522011132 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 507522011133 putative dimer interface [polypeptide binding]; other site 507522011134 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 507522011135 nucleotide binding site/active site [active] 507522011136 HIT family signature motif; other site 507522011137 catalytic residue [active] 507522011138 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 507522011139 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522011140 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522011141 active site turn [active] 507522011142 phosphorylation site [posttranslational modification] 507522011143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 507522011144 active site 507522011145 DNA polymerase III subunit delta'; Validated; Region: PRK07993 507522011146 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 507522011147 thymidylate kinase; Validated; Region: tmk; PRK00698 507522011148 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 507522011149 TMP-binding site; other site 507522011150 ATP-binding site [chemical binding]; other site 507522011151 conserved hypothetical protein, YceG family; Region: TIGR00247 507522011152 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 507522011153 dimerization interface [polypeptide binding]; other site 507522011154 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 507522011155 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 507522011156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522011157 catalytic residue [active] 507522011158 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 507522011159 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 507522011160 dimer interface [polypeptide binding]; other site 507522011161 active site 507522011162 acyl carrier protein; Provisional; Region: acpP; PRK00982 507522011163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 507522011164 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 507522011165 NAD(P) binding site [chemical binding]; other site 507522011166 homotetramer interface [polypeptide binding]; other site 507522011167 homodimer interface [polypeptide binding]; other site 507522011168 active site 507522011169 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 507522011170 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 507522011171 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 507522011172 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 507522011173 dimer interface [polypeptide binding]; other site 507522011174 active site 507522011175 CoA binding pocket [chemical binding]; other site 507522011176 putative phosphate acyltransferase; Provisional; Region: PRK05331 507522011177 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 507522011178 hypothetical protein; Provisional; Region: PRK11193 507522011179 Maf-like protein; Region: Maf; pfam02545 507522011180 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 507522011181 active site 507522011182 dimer interface [polypeptide binding]; other site 507522011183 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 507522011184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522011185 RNA binding surface [nucleotide binding]; other site 507522011186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 507522011187 active site 507522011188 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 507522011189 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 507522011190 homodimer interface [polypeptide binding]; other site 507522011191 oligonucleotide binding site [chemical binding]; other site 507522011192 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 507522011193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522011194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522011195 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522011196 putative effector binding pocket; other site 507522011197 dimerization interface [polypeptide binding]; other site 507522011198 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522011199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011200 putative substrate translocation pore; other site 507522011201 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 507522011202 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 507522011203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522011204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522011205 hypothetical protein; Provisional; Region: PRK11239 507522011206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 507522011207 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 507522011208 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 507522011209 multidrug resistance protein MdtH; Provisional; Region: PRK11646 507522011210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011211 putative substrate translocation pore; other site 507522011212 lipoprotein; Provisional; Region: PRK10598 507522011213 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 507522011214 active site 507522011215 substrate binding pocket [chemical binding]; other site 507522011216 dimer interface [polypeptide binding]; other site 507522011217 DNA damage-inducible protein I; Provisional; Region: PRK10597 507522011218 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 507522011219 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 507522011220 hydroxyglutarate oxidase; Provisional; Region: PRK11728 507522011221 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 507522011222 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 507522011223 active site residue [active] 507522011224 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 507522011225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 507522011226 putative acyl-acceptor binding pocket; other site 507522011227 drug efflux system protein MdtG; Provisional; Region: PRK09874 507522011228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011229 putative substrate translocation pore; other site 507522011230 secY/secA suppressor protein; Provisional; Region: PRK11467 507522011231 lipoprotein; Provisional; Region: PRK10175 507522011232 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 507522011233 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 507522011234 Ligand binding site; other site 507522011235 DXD motif; other site 507522011236 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 507522011237 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 507522011238 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 507522011239 Acyltransferase family; Region: Acyl_transf_3; pfam01757 507522011240 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 507522011241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522011242 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 507522011243 putative ADP-ribose binding site [chemical binding]; other site 507522011244 putative active site [active] 507522011245 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 507522011246 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 507522011247 putative hydrolase; Validated; Region: PRK09248 507522011248 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 507522011249 active site 507522011250 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 507522011251 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 507522011252 putative ligand binding site [chemical binding]; other site 507522011253 NAD binding site [chemical binding]; other site 507522011254 dimerization interface [polypeptide binding]; other site 507522011255 catalytic site [active] 507522011256 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 507522011257 active site 507522011258 Mn binding site [ion binding]; other site 507522011259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522011260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522011261 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 507522011262 LysR family transcriptional regulator; Provisional; Region: PRK14997 507522011263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522011264 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 507522011265 putative effector binding pocket; other site 507522011266 putative dimerization interface [polypeptide binding]; other site 507522011267 Pirin-related protein [General function prediction only]; Region: COG1741 507522011268 Pirin; Region: Pirin; pfam02678 507522011269 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 507522011270 Isochorismatase family; Region: Isochorismatase; pfam00857 507522011271 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 507522011272 catalytic triad [active] 507522011273 dimer interface [polypeptide binding]; other site 507522011274 conserved cis-peptide bond; other site 507522011275 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 507522011276 hypothetical protein; Provisional; Region: PRK10536 507522011277 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 507522011278 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 507522011279 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 507522011280 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 507522011281 Imelysin; Region: Peptidase_M75; pfam09375 507522011282 FTR1 family protein; Region: TIGR00145 507522011283 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 507522011284 Nucleoside recognition; Region: Gate; pfam07670 507522011285 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 507522011286 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 507522011287 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 507522011288 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 507522011289 Na binding site [ion binding]; other site 507522011290 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 507522011291 Predicted transcriptional regulator [Transcription]; Region: COG3905 507522011292 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 507522011293 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 507522011294 Glutamate binding site [chemical binding]; other site 507522011295 NAD binding site [chemical binding]; other site 507522011296 catalytic residues [active] 507522011297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 507522011298 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 507522011299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522011300 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 507522011301 pyrimidine utilization protein A; Region: RutA; TIGR03612 507522011302 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 507522011303 active site 507522011304 dimer interface [polypeptide binding]; other site 507522011305 non-prolyl cis peptide bond; other site 507522011306 insertion regions; other site 507522011307 Isochorismatase family; Region: Isochorismatase; pfam00857 507522011308 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 507522011309 catalytic triad [active] 507522011310 conserved cis-peptide bond; other site 507522011311 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 507522011312 homotrimer interaction site [polypeptide binding]; other site 507522011313 putative active site [active] 507522011314 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 507522011315 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 507522011316 putative FMN binding site [chemical binding]; other site 507522011317 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 507522011318 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 507522011319 EamA-like transporter family; Region: EamA; pfam00892 507522011320 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 507522011321 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522011322 hypothetical protein; Provisional; Region: PRK10174 507522011323 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 507522011324 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 507522011325 catalytic core [active] 507522011326 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 507522011327 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522011328 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522011329 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 507522011330 classical (c) SDRs; Region: SDR_c; cd05233 507522011331 NAD(P) binding site [chemical binding]; other site 507522011332 active site 507522011333 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 507522011334 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 507522011335 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 507522011336 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 507522011337 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 507522011338 catalytic triad [active] 507522011339 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 507522011340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522011341 non-specific DNA binding site [nucleotide binding]; other site 507522011342 salt bridge; other site 507522011343 sequence-specific DNA binding site [nucleotide binding]; other site 507522011344 Cupin domain; Region: Cupin_2; pfam07883 507522011345 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 507522011346 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 507522011347 NAD(P) binding site [chemical binding]; other site 507522011348 catalytic residues [active] 507522011349 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 507522011350 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 507522011351 transcriptional activator TtdR; Provisional; Region: PRK09801 507522011352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522011353 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 507522011354 putative effector binding pocket; other site 507522011355 putative dimerization interface [polypeptide binding]; other site 507522011356 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 507522011357 tartrate dehydrogenase; Region: TTC; TIGR02089 507522011358 putative transporter; Provisional; Region: PRK09950 507522011359 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 507522011360 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 507522011361 [2Fe-2S] cluster binding site [ion binding]; other site 507522011362 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 507522011363 putative alpha subunit interface [polypeptide binding]; other site 507522011364 putative active site [active] 507522011365 putative substrate binding site [chemical binding]; other site 507522011366 Fe binding site [ion binding]; other site 507522011367 succinic semialdehyde dehydrogenase; Region: PLN02278 507522011368 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 507522011369 tetramerization interface [polypeptide binding]; other site 507522011370 NAD(P) binding site [chemical binding]; other site 507522011371 catalytic residues [active] 507522011372 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 507522011373 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 507522011374 FMN-binding pocket [chemical binding]; other site 507522011375 flavin binding motif; other site 507522011376 phosphate binding motif [ion binding]; other site 507522011377 beta-alpha-beta structure motif; other site 507522011378 NAD binding pocket [chemical binding]; other site 507522011379 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522011380 catalytic loop [active] 507522011381 iron binding site [ion binding]; other site 507522011382 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 507522011383 dimerization domain swap beta strand [polypeptide binding]; other site 507522011384 regulatory protein interface [polypeptide binding]; other site 507522011385 active site 507522011386 regulatory phosphorylation site [posttranslational modification]; other site 507522011387 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 507522011388 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 507522011389 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 507522011390 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 507522011391 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522011392 active site 507522011393 phosphorylation site [posttranslational modification] 507522011394 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 507522011395 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 507522011396 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 507522011397 active site 507522011398 P-loop; other site 507522011399 phosphorylation site [posttranslational modification] 507522011400 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 507522011401 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 507522011402 dimer interface [polypeptide binding]; other site 507522011403 active site 507522011404 glycine loop; other site 507522011405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522011406 FeS/SAM binding site; other site 507522011407 pyruvate formate lyase II activase; Provisional; Region: PRK10076 507522011408 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 507522011409 active site 507522011410 P-loop; other site 507522011411 phosphorylation site [posttranslational modification] 507522011412 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 507522011413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522011414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522011415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522011416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522011417 metal binding site [ion binding]; metal-binding site 507522011418 active site 507522011419 I-site; other site 507522011420 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 507522011421 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 507522011422 Walker A/P-loop; other site 507522011423 ATP binding site [chemical binding]; other site 507522011424 Q-loop/lid; other site 507522011425 ABC transporter signature motif; other site 507522011426 Walker B; other site 507522011427 D-loop; other site 507522011428 H-loop/switch region; other site 507522011429 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 507522011430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011431 dimer interface [polypeptide binding]; other site 507522011432 conserved gate region; other site 507522011433 ABC-ATPase subunit interface; other site 507522011434 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 507522011435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011436 dimer interface [polypeptide binding]; other site 507522011437 conserved gate region; other site 507522011438 putative PBP binding loops; other site 507522011439 ABC-ATPase subunit interface; other site 507522011440 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 507522011441 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 507522011442 phage resistance protein; Provisional; Region: PRK10551 507522011443 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 507522011444 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522011445 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 507522011446 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 507522011447 anti sigma factor interaction site; other site 507522011448 regulatory phosphorylation site [posttranslational modification]; other site 507522011449 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 507522011450 homodimer interface [polypeptide binding]; other site 507522011451 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 507522011452 active site pocket [active] 507522011453 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 507522011454 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 507522011455 peptide binding site [polypeptide binding]; other site 507522011456 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 507522011457 YccA-like proteins; Region: YccA_like; cd10433 507522011458 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 507522011459 sulfur transfer protein TusE; Provisional; Region: PRK11508 507522011460 acylphosphatase; Provisional; Region: PRK14426 507522011461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522011462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522011463 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 507522011464 substrate binding site [chemical binding]; other site 507522011465 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 507522011466 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 507522011467 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 507522011468 putative RNA binding site [nucleotide binding]; other site 507522011469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522011470 S-adenosylmethionine binding site [chemical binding]; other site 507522011471 heat shock protein HspQ; Provisional; Region: PRK14129 507522011472 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 507522011473 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 507522011474 active site 507522011475 dimer interfaces [polypeptide binding]; other site 507522011476 catalytic residues [active] 507522011477 DNA helicase IV; Provisional; Region: helD; PRK11054 507522011478 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 507522011479 Part of AAA domain; Region: AAA_19; pfam13245 507522011480 Family description; Region: UvrD_C_2; pfam13538 507522011481 Predicted membrane protein [Function unknown]; Region: COG3304 507522011482 Domain of unknown function (DUF307); Region: DUF307; pfam03733 507522011483 Domain of unknown function (DUF307); Region: DUF307; pfam03733 507522011484 TIGR01666 family membrane protein; Region: YCCS 507522011485 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 507522011486 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 507522011487 TfoX N-terminal domain; Region: TfoX_N; pfam04993 507522011488 TfoX C-terminal domain; Region: TfoX_C; pfam04994 507522011489 SOS cell division inhibitor; Provisional; Region: PRK10595 507522011490 outer membrane protein A; Reviewed; Region: PRK10808 507522011491 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 507522011492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522011493 ligand binding site [chemical binding]; other site 507522011494 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 507522011495 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 507522011496 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 507522011497 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 507522011498 active site 1 [active] 507522011499 dimer interface [polypeptide binding]; other site 507522011500 active site 2 [active] 507522011501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 507522011502 Protein of unknown function (DUF330); Region: DUF330; pfam03886 507522011503 paraquat-inducible protein B; Provisional; Region: PRK10807 507522011504 mce related protein; Region: MCE; pfam02470 507522011505 mce related protein; Region: MCE; pfam02470 507522011506 mce related protein; Region: MCE; pfam02470 507522011507 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 507522011508 Paraquat-inducible protein A; Region: PqiA; pfam04403 507522011509 Paraquat-inducible protein A; Region: PqiA; pfam04403 507522011510 ABC transporter ATPase component; Reviewed; Region: PRK11147 507522011511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522011512 Walker A/P-loop; other site 507522011513 ATP binding site [chemical binding]; other site 507522011514 Q-loop/lid; other site 507522011515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522011516 ABC transporter; Region: ABC_tran_2; pfam12848 507522011517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522011518 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 507522011519 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 507522011520 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 507522011521 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 507522011522 putative RNA binding site [nucleotide binding]; other site 507522011523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522011524 S-adenosylmethionine binding site [chemical binding]; other site 507522011525 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 507522011526 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 507522011527 MOSC domain; Region: MOSC; pfam03473 507522011528 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 507522011529 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522011530 catalytic loop [active] 507522011531 iron binding site [ion binding]; other site 507522011532 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 507522011533 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 507522011534 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 507522011535 quinone interaction residues [chemical binding]; other site 507522011536 active site 507522011537 catalytic residues [active] 507522011538 FMN binding site [chemical binding]; other site 507522011539 substrate binding site [chemical binding]; other site 507522011540 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 507522011541 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522011542 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 507522011543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522011544 substrate binding pocket [chemical binding]; other site 507522011545 membrane-bound complex binding site; other site 507522011546 hinge residues; other site 507522011547 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 507522011548 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 507522011549 active site 507522011550 dimer interface [polypeptide binding]; other site 507522011551 non-prolyl cis peptide bond; other site 507522011552 insertion regions; other site 507522011553 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522011554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011555 dimer interface [polypeptide binding]; other site 507522011556 conserved gate region; other site 507522011557 putative PBP binding loops; other site 507522011558 ABC-ATPase subunit interface; other site 507522011559 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 507522011560 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522011561 Walker A/P-loop; other site 507522011562 ATP binding site [chemical binding]; other site 507522011563 Q-loop/lid; other site 507522011564 ABC transporter signature motif; other site 507522011565 Walker B; other site 507522011566 D-loop; other site 507522011567 H-loop/switch region; other site 507522011568 aminopeptidase N; Provisional; Region: pepN; PRK14015 507522011569 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 507522011570 active site 507522011571 Zn binding site [ion binding]; other site 507522011572 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 507522011573 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 507522011574 active site 507522011575 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 507522011576 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 507522011577 putative dimer interface [polypeptide binding]; other site 507522011578 putative anticodon binding site; other site 507522011579 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 507522011580 homodimer interface [polypeptide binding]; other site 507522011581 motif 1; other site 507522011582 motif 2; other site 507522011583 active site 507522011584 motif 3; other site 507522011585 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522011586 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 507522011587 eyelet of channel; other site 507522011588 trimer interface [polypeptide binding]; other site 507522011589 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 507522011590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522011591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522011592 homodimer interface [polypeptide binding]; other site 507522011593 catalytic residue [active] 507522011594 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 507522011595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 507522011596 Peptidase M15; Region: Peptidase_M15_3; cl01194 507522011597 murein L,D-transpeptidase; Provisional; Region: PRK10594 507522011598 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 507522011599 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522011600 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522011601 cell division protein MukB; Provisional; Region: mukB; PRK04863 507522011602 P-loop containing region of AAA domain; Region: AAA_29; cl17516 507522011603 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 507522011604 condesin subunit E; Provisional; Region: PRK05256 507522011605 condesin subunit F; Provisional; Region: PRK05260 507522011606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522011607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522011608 S-adenosylmethionine binding site [chemical binding]; other site 507522011609 Uncharacterized conserved protein [Function unknown]; Region: COG1434 507522011610 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 507522011611 putative active site [active] 507522011612 hypothetical protein; Provisional; Region: PRK10593 507522011613 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 507522011614 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 507522011615 Ligand binding site; other site 507522011616 oligomer interface; other site 507522011617 Trm112p-like protein; Region: Trm112p; cl01066 507522011618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 507522011619 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 507522011620 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 507522011621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522011622 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 507522011623 Walker A/P-loop; other site 507522011624 ATP binding site [chemical binding]; other site 507522011625 Q-loop/lid; other site 507522011626 ABC transporter signature motif; other site 507522011627 Walker B; other site 507522011628 D-loop; other site 507522011629 H-loop/switch region; other site 507522011630 ComEC family competence protein; Provisional; Region: PRK11539 507522011631 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 507522011632 Competence protein; Region: Competence; pfam03772 507522011633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 507522011634 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 507522011635 IHF dimer interface [polypeptide binding]; other site 507522011636 IHF - DNA interface [nucleotide binding]; other site 507522011637 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 507522011638 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 507522011639 RNA binding site [nucleotide binding]; other site 507522011640 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 507522011641 RNA binding site [nucleotide binding]; other site 507522011642 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 507522011643 RNA binding site [nucleotide binding]; other site 507522011644 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 507522011645 RNA binding site [nucleotide binding]; other site 507522011646 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 507522011647 RNA binding site [nucleotide binding]; other site 507522011648 cytidylate kinase; Provisional; Region: cmk; PRK00023 507522011649 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 507522011650 CMP-binding site; other site 507522011651 The sites determining sugar specificity; other site 507522011652 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 507522011653 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 507522011654 hinge; other site 507522011655 active site 507522011656 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 507522011657 homodimer interface [polypeptide binding]; other site 507522011658 substrate-cofactor binding pocket; other site 507522011659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522011660 catalytic residue [active] 507522011661 Predicted membrane protein [Function unknown]; Region: COG2323 507522011662 uncharacterized domain; Region: TIGR00702 507522011663 YcaO-like family; Region: YcaO; pfam02624 507522011664 formate transporter; Provisional; Region: PRK10805 507522011665 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 507522011666 Pyruvate formate lyase 1; Region: PFL1; cd01678 507522011667 coenzyme A binding site [chemical binding]; other site 507522011668 active site 507522011669 catalytic residues [active] 507522011670 glycine loop; other site 507522011671 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 507522011672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522011673 FeS/SAM binding site; other site 507522011674 putative MFS family transporter protein; Provisional; Region: PRK03633 507522011675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011676 putative substrate translocation pore; other site 507522011677 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 507522011678 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 507522011679 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 507522011680 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 507522011681 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 507522011682 putative [Fe4-S4] binding site [ion binding]; other site 507522011683 putative molybdopterin cofactor binding site [chemical binding]; other site 507522011684 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 507522011685 putative molybdopterin cofactor binding site; other site 507522011686 seryl-tRNA synthetase; Provisional; Region: PRK05431 507522011687 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 507522011688 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 507522011689 dimer interface [polypeptide binding]; other site 507522011690 active site 507522011691 motif 1; other site 507522011692 motif 2; other site 507522011693 motif 3; other site 507522011694 recombination factor protein RarA; Reviewed; Region: PRK13342 507522011695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522011696 Walker A motif; other site 507522011697 ATP binding site [chemical binding]; other site 507522011698 Walker B motif; other site 507522011699 arginine finger; other site 507522011700 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 507522011701 periplasmic chaperone LolA; Region: lolA; TIGR00547 507522011702 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 507522011703 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 507522011704 DNA translocase FtsK; Provisional; Region: PRK10263 507522011705 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 507522011706 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 507522011707 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 507522011708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522011709 putative DNA binding site [nucleotide binding]; other site 507522011710 putative Zn2+ binding site [ion binding]; other site 507522011711 AsnC family; Region: AsnC_trans_reg; pfam01037 507522011712 thioredoxin reductase; Provisional; Region: PRK10262 507522011713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522011714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522011715 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 507522011716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522011717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522011718 Walker A/P-loop; other site 507522011719 ATP binding site [chemical binding]; other site 507522011720 Q-loop/lid; other site 507522011721 ABC transporter signature motif; other site 507522011722 Walker B; other site 507522011723 D-loop; other site 507522011724 H-loop/switch region; other site 507522011725 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 507522011726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522011727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522011728 Walker A/P-loop; other site 507522011729 ATP binding site [chemical binding]; other site 507522011730 Q-loop/lid; other site 507522011731 ABC transporter signature motif; other site 507522011732 Walker B; other site 507522011733 D-loop; other site 507522011734 H-loop/switch region; other site 507522011735 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 507522011736 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 507522011737 rRNA binding site [nucleotide binding]; other site 507522011738 predicted 30S ribosome binding site; other site 507522011739 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 507522011740 Clp amino terminal domain; Region: Clp_N; pfam02861 507522011741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522011742 Walker A motif; other site 507522011743 ATP binding site [chemical binding]; other site 507522011744 Walker B motif; other site 507522011745 arginine finger; other site 507522011746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522011747 Walker A motif; other site 507522011748 ATP binding site [chemical binding]; other site 507522011749 Walker B motif; other site 507522011750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 507522011751 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 507522011752 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522011753 DNA-binding site [nucleotide binding]; DNA binding site 507522011754 RNA-binding motif; other site 507522011755 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 507522011756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 507522011757 Walker A/P-loop; other site 507522011758 ATP binding site [chemical binding]; other site 507522011759 Q-loop/lid; other site 507522011760 ABC transporter signature motif; other site 507522011761 Walker B; other site 507522011762 D-loop; other site 507522011763 H-loop/switch region; other site 507522011764 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 507522011765 FtsX-like permease family; Region: FtsX; pfam02687 507522011766 macrolide transporter subunit MacA; Provisional; Region: PRK11578 507522011767 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522011768 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522011769 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 507522011770 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 507522011771 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 507522011772 putative active site [active] 507522011773 putative metal-binding site [ion binding]; other site 507522011774 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 507522011775 amphipathic channel; other site 507522011776 Asn-Pro-Ala signature motifs; other site 507522011777 Predicted membrane protein [Function unknown]; Region: COG2431 507522011778 hybrid cluster protein; Provisional; Region: PRK05290 507522011779 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522011780 ACS interaction site; other site 507522011781 CODH interaction site; other site 507522011782 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 507522011783 hybrid metal cluster; other site 507522011784 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 507522011785 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 507522011786 FAD binding pocket [chemical binding]; other site 507522011787 FAD binding motif [chemical binding]; other site 507522011788 phosphate binding motif [ion binding]; other site 507522011789 beta-alpha-beta structure motif; other site 507522011790 NAD binding pocket [chemical binding]; other site 507522011791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522011792 catalytic loop [active] 507522011793 iron binding site [ion binding]; other site 507522011794 DoxX; Region: DoxX; pfam07681 507522011795 pyruvate dehydrogenase; Provisional; Region: PRK09124 507522011796 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 507522011797 PYR/PP interface [polypeptide binding]; other site 507522011798 dimer interface [polypeptide binding]; other site 507522011799 tetramer interface [polypeptide binding]; other site 507522011800 TPP binding site [chemical binding]; other site 507522011801 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522011802 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 507522011803 TPP-binding site [chemical binding]; other site 507522011804 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 507522011805 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 507522011806 tetramer interface [polypeptide binding]; other site 507522011807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522011808 catalytic residue [active] 507522011809 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 507522011810 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 507522011811 putative NAD(P) binding site [chemical binding]; other site 507522011812 putative active site [active] 507522011813 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 507522011814 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 507522011815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522011816 NAD(P) binding site [chemical binding]; other site 507522011817 active site 507522011818 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 507522011819 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 507522011820 amidase catalytic site [active] 507522011821 Zn binding residues [ion binding]; other site 507522011822 substrate binding site [chemical binding]; other site 507522011823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522011824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522011825 metal binding site [ion binding]; metal-binding site 507522011826 active site 507522011827 I-site; other site 507522011828 hypothetical protein; Provisional; Region: PRK09929 507522011829 putative lipoprotein; Provisional; Region: PRK10533 507522011830 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 507522011831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522011832 Walker A/P-loop; other site 507522011833 ATP binding site [chemical binding]; other site 507522011834 Q-loop/lid; other site 507522011835 ABC transporter signature motif; other site 507522011836 Walker B; other site 507522011837 D-loop; other site 507522011838 H-loop/switch region; other site 507522011839 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 507522011840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522011841 substrate binding pocket [chemical binding]; other site 507522011842 membrane-bound complex binding site; other site 507522011843 hinge residues; other site 507522011844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522011845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011846 dimer interface [polypeptide binding]; other site 507522011847 conserved gate region; other site 507522011848 putative PBP binding loops; other site 507522011849 ABC-ATPase subunit interface; other site 507522011850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011851 dimer interface [polypeptide binding]; other site 507522011852 conserved gate region; other site 507522011853 putative PBP binding loops; other site 507522011854 ABC-ATPase subunit interface; other site 507522011855 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 507522011856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522011857 substrate binding pocket [chemical binding]; other site 507522011858 membrane-bound complex binding site; other site 507522011859 hinge residues; other site 507522011860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522011861 dimer interface [polypeptide binding]; other site 507522011862 phosphorylation site [posttranslational modification] 507522011863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522011864 ATP binding site [chemical binding]; other site 507522011865 Mg2+ binding site [ion binding]; other site 507522011866 G-X-G motif; other site 507522011867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 507522011868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522011869 active site 507522011870 phosphorylation site [posttranslational modification] 507522011871 intermolecular recognition site; other site 507522011872 dimerization interface [polypeptide binding]; other site 507522011873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522011874 DNA binding site [nucleotide binding] 507522011875 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 507522011876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522011877 S-adenosylmethionine binding site [chemical binding]; other site 507522011878 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 507522011879 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522011880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011881 dimer interface [polypeptide binding]; other site 507522011882 conserved gate region; other site 507522011883 putative PBP binding loops; other site 507522011884 ABC-ATPase subunit interface; other site 507522011885 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 507522011886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011887 dimer interface [polypeptide binding]; other site 507522011888 conserved gate region; other site 507522011889 putative PBP binding loops; other site 507522011890 ABC-ATPase subunit interface; other site 507522011891 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 507522011892 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 507522011893 Walker A/P-loop; other site 507522011894 ATP binding site [chemical binding]; other site 507522011895 Q-loop/lid; other site 507522011896 ABC transporter signature motif; other site 507522011897 Walker B; other site 507522011898 D-loop; other site 507522011899 H-loop/switch region; other site 507522011900 TOBE domain; Region: TOBE_2; pfam08402 507522011901 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 507522011902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 507522011903 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 507522011904 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 507522011905 RimK-like ATP-grasp domain; Region: RimK; pfam08443 507522011906 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 507522011907 dimer interface [polypeptide binding]; other site 507522011908 FMN binding site [chemical binding]; other site 507522011909 NADPH bind site [chemical binding]; other site 507522011910 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 507522011911 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 507522011912 GSH binding site [chemical binding]; other site 507522011913 catalytic residues [active] 507522011914 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 507522011915 putative transporter; Provisional; Region: PRK04972 507522011916 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 507522011917 TrkA-C domain; Region: TrkA_C; pfam02080 507522011918 TrkA-C domain; Region: TrkA_C; pfam02080 507522011919 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 507522011920 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 507522011921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522011922 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 507522011923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522011925 putative substrate translocation pore; other site 507522011926 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 507522011927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522011928 active site 507522011929 motif I; other site 507522011930 motif II; other site 507522011931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522011932 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 507522011933 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 507522011934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011935 putative substrate translocation pore; other site 507522011936 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 507522011937 active site 507522011938 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 507522011939 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 507522011940 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522011941 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 507522011942 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 507522011943 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 507522011944 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522011945 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 507522011946 putative C-terminal domain interface [polypeptide binding]; other site 507522011947 putative GSH binding site (G-site) [chemical binding]; other site 507522011948 putative dimer interface [polypeptide binding]; other site 507522011949 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 507522011950 putative N-terminal domain interface [polypeptide binding]; other site 507522011951 putative dimer interface [polypeptide binding]; other site 507522011952 putative substrate binding pocket (H-site) [chemical binding]; other site 507522011953 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 507522011954 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 507522011955 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 507522011956 galactoside permease; Reviewed; Region: lacY; PRK09528 507522011957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522011958 putative substrate translocation pore; other site 507522011959 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 507522011960 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 507522011961 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 507522011962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522011963 FeS/SAM binding site; other site 507522011964 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 507522011965 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522011966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011967 dimer interface [polypeptide binding]; other site 507522011968 conserved gate region; other site 507522011969 putative PBP binding loops; other site 507522011970 ABC-ATPase subunit interface; other site 507522011971 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 507522011972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522011973 dimer interface [polypeptide binding]; other site 507522011974 conserved gate region; other site 507522011975 putative PBP binding loops; other site 507522011976 ABC-ATPase subunit interface; other site 507522011977 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 507522011978 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 507522011979 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 507522011980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522011981 Walker A/P-loop; other site 507522011982 ATP binding site [chemical binding]; other site 507522011983 Q-loop/lid; other site 507522011984 ABC transporter signature motif; other site 507522011985 Walker B; other site 507522011986 D-loop; other site 507522011987 H-loop/switch region; other site 507522011988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522011989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522011990 Walker A/P-loop; other site 507522011991 ATP binding site [chemical binding]; other site 507522011992 Q-loop/lid; other site 507522011993 ABC transporter signature motif; other site 507522011994 Walker B; other site 507522011995 D-loop; other site 507522011996 H-loop/switch region; other site 507522011997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 507522011998 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 507522011999 catalytic nucleophile [active] 507522012000 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 507522012001 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 507522012002 dimer interface [polypeptide binding]; other site 507522012003 putative functional site; other site 507522012004 putative MPT binding site; other site 507522012005 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 507522012006 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 507522012007 ATP binding site [chemical binding]; other site 507522012008 substrate interface [chemical binding]; other site 507522012009 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 507522012010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522012011 FeS/SAM binding site; other site 507522012012 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 507522012013 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 507522012014 dimer interface [polypeptide binding]; other site 507522012015 active site 507522012016 glycine loop; other site 507522012017 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 507522012018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012019 active site 507522012020 motif I; other site 507522012021 motif II; other site 507522012022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012023 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 507522012024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522012025 DNA binding site [nucleotide binding] 507522012026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522012027 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 507522012028 ligand binding site [chemical binding]; other site 507522012029 dimerization interface [polypeptide binding]; other site 507522012030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012031 D-galactonate transporter; Region: 2A0114; TIGR00893 507522012032 putative substrate translocation pore; other site 507522012033 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 507522012034 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 507522012035 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 507522012036 putative active site [active] 507522012037 putative catalytic site [active] 507522012038 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 507522012039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522012040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522012041 Walker A/P-loop; other site 507522012042 ATP binding site [chemical binding]; other site 507522012043 Q-loop/lid; other site 507522012044 ABC transporter signature motif; other site 507522012045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522012046 Walker B; other site 507522012047 D-loop; other site 507522012048 ABC transporter; Region: ABC_tran_2; pfam12848 507522012049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522012050 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 507522012051 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 507522012052 L,D-transpeptidase; Provisional; Region: PRK10260 507522012053 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 507522012054 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522012055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522012056 DNA-binding site [nucleotide binding]; DNA binding site 507522012057 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 507522012058 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 507522012059 beta-galactosidase; Region: BGL; TIGR03356 507522012060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522012061 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522012062 active site 507522012063 catalytic tetrad [active] 507522012064 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522012065 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 507522012066 transmembrane helices; other site 507522012067 manganese transport regulator MntR; Provisional; Region: PRK11050 507522012068 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 507522012069 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 507522012070 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 507522012071 Sulfatase; Region: Sulfatase; pfam00884 507522012072 outer membrane protein X; Provisional; Region: ompX; PRK09408 507522012073 threonine and homoserine efflux system; Provisional; Region: PRK10532 507522012074 EamA-like transporter family; Region: EamA; pfam00892 507522012075 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 507522012076 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 507522012077 dimerization interface [polypeptide binding]; other site 507522012078 DPS ferroxidase diiron center [ion binding]; other site 507522012079 ion pore; other site 507522012080 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 507522012081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522012082 substrate binding pocket [chemical binding]; other site 507522012083 membrane-bound complex binding site; other site 507522012084 hinge residues; other site 507522012085 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522012086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012087 dimer interface [polypeptide binding]; other site 507522012088 conserved gate region; other site 507522012089 putative PBP binding loops; other site 507522012090 ABC-ATPase subunit interface; other site 507522012091 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 507522012092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522012093 Walker A/P-loop; other site 507522012094 ATP binding site [chemical binding]; other site 507522012095 Q-loop/lid; other site 507522012096 ABC transporter signature motif; other site 507522012097 Walker B; other site 507522012098 D-loop; other site 507522012099 H-loop/switch region; other site 507522012100 putative mechanosensitive channel protein; Provisional; Region: PRK11465 507522012101 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522012102 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 507522012103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522012104 S-adenosylmethionine binding site [chemical binding]; other site 507522012105 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 507522012106 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522012107 hypothetical protein; Provisional; Region: PRK11019 507522012108 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 507522012109 glycosyl transferase family protein; Provisional; Region: PRK08136 507522012110 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 507522012111 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 507522012112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 507522012113 DEAD_2; Region: DEAD_2; pfam06733 507522012114 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 507522012115 helicase 45; Provisional; Region: PTZ00424 507522012116 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 507522012117 ATP binding site [chemical binding]; other site 507522012118 Mg++ binding site [ion binding]; other site 507522012119 motif III; other site 507522012120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522012121 nucleotide binding region [chemical binding]; other site 507522012122 ATP-binding site [chemical binding]; other site 507522012123 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 507522012124 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522012125 PYR/PP interface [polypeptide binding]; other site 507522012126 dimer interface [polypeptide binding]; other site 507522012127 TPP binding site [chemical binding]; other site 507522012128 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522012129 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522012130 TPP-binding site [chemical binding]; other site 507522012131 dimer interface [polypeptide binding]; other site 507522012132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522012133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522012134 NAD(P) binding site [chemical binding]; other site 507522012135 active site 507522012136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012137 D-galactonate transporter; Region: 2A0114; TIGR00893 507522012138 putative substrate translocation pore; other site 507522012139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012140 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 507522012141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522012142 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522012143 dimerization interface [polypeptide binding]; other site 507522012144 substrate binding pocket [chemical binding]; other site 507522012145 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 507522012146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522012147 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 507522012148 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 507522012149 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522012150 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522012151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 507522012152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522012153 Walker A/P-loop; other site 507522012154 ATP binding site [chemical binding]; other site 507522012155 Q-loop/lid; other site 507522012156 ABC transporter signature motif; other site 507522012157 Walker B; other site 507522012158 D-loop; other site 507522012159 H-loop/switch region; other site 507522012160 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 507522012161 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522012162 Walker A/P-loop; other site 507522012163 ATP binding site [chemical binding]; other site 507522012164 Q-loop/lid; other site 507522012165 ABC transporter signature motif; other site 507522012166 Walker B; other site 507522012167 D-loop; other site 507522012168 H-loop/switch region; other site 507522012169 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522012170 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 507522012171 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522012172 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 507522012173 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 507522012174 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 507522012175 putative catalytic site [active] 507522012176 putative metal binding site [ion binding]; other site 507522012177 putative phosphate binding site [ion binding]; other site 507522012178 cardiolipin synthase 2; Provisional; Region: PRK11263 507522012179 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 507522012180 putative active site [active] 507522012181 catalytic site [active] 507522012182 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 507522012183 putative active site [active] 507522012184 catalytic site [active] 507522012185 Predicted integral membrane protein [Function unknown]; Region: COG0392 507522012186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 507522012187 Transposase; Region: DEDD_Tnp_IS110; pfam01548 507522012188 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 507522012189 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 507522012190 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 507522012191 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 507522012192 MoaE homodimer interface [polypeptide binding]; other site 507522012193 MoaD interaction [polypeptide binding]; other site 507522012194 active site residues [active] 507522012195 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 507522012196 MoaE interaction surface [polypeptide binding]; other site 507522012197 MoeB interaction surface [polypeptide binding]; other site 507522012198 thiocarboxylated glycine; other site 507522012199 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 507522012200 trimer interface [polypeptide binding]; other site 507522012201 dimer interface [polypeptide binding]; other site 507522012202 putative active site [active] 507522012203 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 507522012204 MPT binding site; other site 507522012205 trimer interface [polypeptide binding]; other site 507522012206 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 507522012207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522012208 FeS/SAM binding site; other site 507522012209 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 507522012210 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 507522012211 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 507522012212 phosphate binding site [ion binding]; other site 507522012213 putative substrate binding pocket [chemical binding]; other site 507522012214 dimer interface [polypeptide binding]; other site 507522012215 putative metal dependent hydrolase; Provisional; Region: PRK11598 507522012216 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 507522012217 Sulfatase; Region: Sulfatase; pfam00884 507522012218 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 507522012219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522012220 active site 507522012221 phosphorylation site [posttranslational modification] 507522012222 intermolecular recognition site; other site 507522012223 dimerization interface [polypeptide binding]; other site 507522012224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522012225 DNA binding site [nucleotide binding] 507522012226 sensor protein BasS/PmrB; Provisional; Region: PRK10755 507522012227 HAMP domain; Region: HAMP; pfam00672 507522012228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522012229 dimer interface [polypeptide binding]; other site 507522012230 phosphorylation site [posttranslational modification] 507522012231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522012232 ATP binding site [chemical binding]; other site 507522012233 Mg2+ binding site [ion binding]; other site 507522012234 G-X-G motif; other site 507522012235 excinuclease ABC subunit B; Provisional; Region: PRK05298 507522012236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522012237 ATP binding site [chemical binding]; other site 507522012238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522012239 nucleotide binding region [chemical binding]; other site 507522012240 ATP-binding site [chemical binding]; other site 507522012241 Ultra-violet resistance protein B; Region: UvrB; pfam12344 507522012242 UvrB/uvrC motif; Region: UVR; pfam02151 507522012243 AAA domain; Region: AAA_26; pfam13500 507522012244 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 507522012245 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 507522012246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522012247 S-adenosylmethionine binding site [chemical binding]; other site 507522012248 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 507522012249 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 507522012250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522012251 catalytic residue [active] 507522012252 biotin synthase; Provisional; Region: PRK15108 507522012253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522012254 FeS/SAM binding site; other site 507522012255 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 507522012256 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 507522012257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522012258 inhibitor-cofactor binding pocket; inhibition site 507522012259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522012260 catalytic residue [active] 507522012261 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 507522012262 substrate binding site [chemical binding]; other site 507522012263 putative proline-specific permease; Provisional; Region: proY; PRK10580 507522012264 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 507522012265 active sites [active] 507522012266 tetramer interface [polypeptide binding]; other site 507522012267 urocanate hydratase; Provisional; Region: PRK05414 507522012268 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 507522012269 histidine utilization repressor; Provisional; Region: PRK14999 507522012270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522012271 DNA-binding site [nucleotide binding]; DNA binding site 507522012272 UTRA domain; Region: UTRA; pfam07702 507522012273 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 507522012274 putative active site [active] 507522012275 putative metal binding site [ion binding]; other site 507522012276 imidazolonepropionase; Validated; Region: PRK09356 507522012277 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 507522012278 active site 507522012279 acyl-CoA thioesterase; Provisional; Region: PRK10531 507522012280 putative pectinesterase; Region: PLN02432; cl01911 507522012281 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 507522012282 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 507522012283 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522012284 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 507522012285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012286 motif I; other site 507522012287 motif II; other site 507522012288 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 507522012289 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522012290 Ligand Binding Site [chemical binding]; other site 507522012291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522012292 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522012293 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522012294 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 507522012295 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 507522012296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522012297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522012298 DNA binding residues [nucleotide binding] 507522012299 dimerization interface [polypeptide binding]; other site 507522012300 transcriptional regulator MirA; Provisional; Region: PRK15043 507522012301 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 507522012302 DNA binding residues [nucleotide binding] 507522012303 Sensors of blue-light using FAD; Region: BLUF; pfam04940 507522012304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522012305 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 507522012306 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 507522012307 6-phosphogluconolactonase; Provisional; Region: PRK11028 507522012308 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 507522012309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012310 active site 507522012311 motif I; other site 507522012312 motif II; other site 507522012313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012314 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 507522012315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522012316 Walker A/P-loop; other site 507522012317 ATP binding site [chemical binding]; other site 507522012318 Q-loop/lid; other site 507522012319 ABC transporter signature motif; other site 507522012320 Walker B; other site 507522012321 D-loop; other site 507522012322 H-loop/switch region; other site 507522012323 TOBE domain; Region: TOBE; cl01440 507522012324 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 507522012325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012326 dimer interface [polypeptide binding]; other site 507522012327 conserved gate region; other site 507522012328 putative PBP binding loops; other site 507522012329 ABC-ATPase subunit interface; other site 507522012330 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 507522012331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522012332 substrate binding pocket [chemical binding]; other site 507522012333 membrane-bound complex binding site; other site 507522012334 hinge residues; other site 507522012335 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 507522012336 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 507522012337 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 507522012338 molybdenum-pterin binding domain; Region: Mop; TIGR00638 507522012339 TOBE domain; Region: TOBE; pfam03459 507522012340 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 507522012341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522012342 Walker A/P-loop; other site 507522012343 ATP binding site [chemical binding]; other site 507522012344 Q-loop/lid; other site 507522012345 ABC transporter signature motif; other site 507522012346 Walker B; other site 507522012347 D-loop; other site 507522012348 H-loop/switch region; other site 507522012349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522012350 Walker A/P-loop; other site 507522012351 ATP binding site [chemical binding]; other site 507522012352 Q-loop/lid; other site 507522012353 ABC transporter signature motif; other site 507522012354 Walker B; other site 507522012355 D-loop; other site 507522012356 H-loop/switch region; other site 507522012357 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 507522012358 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 507522012359 NAD binding site [chemical binding]; other site 507522012360 homodimer interface [polypeptide binding]; other site 507522012361 active site 507522012362 substrate binding site [chemical binding]; other site 507522012363 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 507522012364 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 507522012365 dimer interface [polypeptide binding]; other site 507522012366 active site 507522012367 galactokinase; Provisional; Region: PRK05101 507522012368 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 507522012369 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 507522012370 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 507522012371 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 507522012372 active site 507522012373 catalytic residues [active] 507522012374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 507522012375 catalytic core [active] 507522012376 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 507522012377 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 507522012378 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 507522012379 YbgS-like protein; Region: YbgS; pfam13985 507522012380 zinc transporter ZitB; Provisional; Region: PRK03557 507522012381 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 507522012382 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 507522012383 quinolinate synthetase; Provisional; Region: PRK09375 507522012384 tol-pal system protein YbgF; Provisional; Region: PRK10803 507522012385 Tetratricopeptide repeat; Region: TPR_6; pfam13174 507522012386 Tetratricopeptide repeat; Region: TPR_6; pfam13174 507522012387 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 507522012388 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 507522012389 ligand binding site [chemical binding]; other site 507522012390 translocation protein TolB; Provisional; Region: tolB; PRK03629 507522012391 TolB amino-terminal domain; Region: TolB_N; pfam04052 507522012392 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 507522012393 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 507522012394 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 507522012395 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 507522012396 TolA C-terminal; Region: TolA; pfam06519 507522012397 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 507522012398 colicin uptake protein TolR; Provisional; Region: PRK11024 507522012399 colicin uptake protein TolQ; Provisional; Region: PRK10801 507522012400 hypothetical protein; Provisional; Region: PRK10588 507522012401 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 507522012402 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 507522012403 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 507522012404 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 507522012405 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 507522012406 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 507522012407 CoA binding domain; Region: CoA_binding; smart00881 507522012408 CoA-ligase; Region: Ligase_CoA; pfam00549 507522012409 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 507522012410 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 507522012411 CoA-ligase; Region: Ligase_CoA; pfam00549 507522012412 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 507522012413 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522012414 E3 interaction surface; other site 507522012415 lipoyl attachment site [posttranslational modification]; other site 507522012416 e3 binding domain; Region: E3_binding; pfam02817 507522012417 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 507522012418 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 507522012419 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 507522012420 TPP-binding site [chemical binding]; other site 507522012421 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 507522012422 dimer interface [polypeptide binding]; other site 507522012423 PYR/PP interface [polypeptide binding]; other site 507522012424 TPP binding site [chemical binding]; other site 507522012425 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 507522012426 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 507522012427 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 507522012428 L-aspartate oxidase; Provisional; Region: PRK06175 507522012429 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 507522012430 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 507522012431 SdhC subunit interface [polypeptide binding]; other site 507522012432 proximal heme binding site [chemical binding]; other site 507522012433 cardiolipin binding site; other site 507522012434 Iron-sulfur protein interface; other site 507522012435 proximal quinone binding site [chemical binding]; other site 507522012436 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 507522012437 Iron-sulfur protein interface; other site 507522012438 proximal quinone binding site [chemical binding]; other site 507522012439 SdhD (CybS) interface [polypeptide binding]; other site 507522012440 proximal heme binding site [chemical binding]; other site 507522012441 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 507522012442 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 507522012443 dimer interface [polypeptide binding]; other site 507522012444 active site 507522012445 citrylCoA binding site [chemical binding]; other site 507522012446 NADH binding [chemical binding]; other site 507522012447 cationic pore residues; other site 507522012448 oxalacetate/citrate binding site [chemical binding]; other site 507522012449 coenzyme A binding site [chemical binding]; other site 507522012450 catalytic triad [active] 507522012451 endonuclease VIII; Provisional; Region: PRK10445 507522012452 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 507522012453 DNA binding site [nucleotide binding] 507522012454 catalytic residue [active] 507522012455 putative catalytic residues [active] 507522012456 H2TH interface [polypeptide binding]; other site 507522012457 intercalation triad [nucleotide binding]; other site 507522012458 substrate specificity determining residue; other site 507522012459 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 507522012460 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 507522012461 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 507522012462 putative substrate binding pocket [chemical binding]; other site 507522012463 AC domain interface; other site 507522012464 catalytic triad [active] 507522012465 AB domain interface; other site 507522012466 interchain disulfide; other site 507522012467 LamB/YcsF family protein; Provisional; Region: PRK05406 507522012468 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 507522012469 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 507522012470 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 507522012471 Uncharacterized conserved protein [Function unknown]; Region: COG0327 507522012472 metal-binding protein; Provisional; Region: PRK10799 507522012473 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 507522012474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012475 putative substrate translocation pore; other site 507522012476 POT family; Region: PTR2; pfam00854 507522012477 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 507522012478 DNA photolyase; Region: DNA_photolyase; pfam00875 507522012479 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 507522012480 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 507522012481 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 507522012482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522012483 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 507522012484 sensor protein KdpD; Provisional; Region: PRK10490 507522012485 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 507522012486 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 507522012487 Ligand Binding Site [chemical binding]; other site 507522012488 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 507522012489 GAF domain; Region: GAF_3; pfam13492 507522012490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522012491 dimer interface [polypeptide binding]; other site 507522012492 phosphorylation site [posttranslational modification] 507522012493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522012494 ATP binding site [chemical binding]; other site 507522012495 Mg2+ binding site [ion binding]; other site 507522012496 G-X-G motif; other site 507522012497 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 507522012498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522012499 active site 507522012500 phosphorylation site [posttranslational modification] 507522012501 intermolecular recognition site; other site 507522012502 dimerization interface [polypeptide binding]; other site 507522012503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522012504 DNA binding site [nucleotide binding] 507522012505 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 507522012506 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 507522012507 active site 507522012508 substrate binding site [chemical binding]; other site 507522012509 metal binding site [ion binding]; metal-binding site 507522012510 replication initiation regulator SeqA; Provisional; Region: PRK11187 507522012511 acyl-CoA esterase; Provisional; Region: PRK10673 507522012512 PGAP1-like protein; Region: PGAP1; pfam07819 507522012513 LexA regulated protein; Provisional; Region: PRK11675 507522012514 flavodoxin FldA; Validated; Region: PRK09267 507522012515 ferric uptake regulator; Provisional; Region: fur; PRK09462 507522012516 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 507522012517 metal binding site 2 [ion binding]; metal-binding site 507522012518 putative DNA binding helix; other site 507522012519 metal binding site 1 [ion binding]; metal-binding site 507522012520 dimer interface [polypeptide binding]; other site 507522012521 structural Zn2+ binding site [ion binding]; other site 507522012522 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 507522012523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522012524 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 507522012525 putative dimerization interface [polypeptide binding]; other site 507522012526 tricarballylate dehydrogenase; Validated; Region: PRK08274 507522012527 tricarballylate utilization protein B; Provisional; Region: PRK15033 507522012528 citrate-proton symporter; Provisional; Region: PRK15075 507522012529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012530 putative substrate translocation pore; other site 507522012531 YbfN-like lipoprotein; Region: YbfN; pfam13982 507522012532 outer membrane porin, OprD family; Region: OprD; pfam03573 507522012533 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 507522012534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 507522012535 active site 507522012536 HIGH motif; other site 507522012537 nucleotide binding site [chemical binding]; other site 507522012538 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 507522012539 KMSKS motif; other site 507522012540 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 507522012541 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 507522012542 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522012543 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522012544 active site turn [active] 507522012545 phosphorylation site [posttranslational modification] 507522012546 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 507522012547 HPr interaction site; other site 507522012548 glycerol kinase (GK) interaction site [polypeptide binding]; other site 507522012549 active site 507522012550 phosphorylation site [posttranslational modification] 507522012551 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 507522012552 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 507522012553 active site 507522012554 trimer interface [polypeptide binding]; other site 507522012555 allosteric site; other site 507522012556 active site lid [active] 507522012557 hexamer (dimer of trimers) interface [polypeptide binding]; other site 507522012558 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 507522012559 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 507522012560 active site 507522012561 dimer interface [polypeptide binding]; other site 507522012562 MarR family; Region: MarR; pfam01047 507522012563 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 507522012564 ROK family; Region: ROK; pfam00480 507522012565 UMP phosphatase; Provisional; Region: PRK10444 507522012566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012567 active site 507522012568 motif I; other site 507522012569 motif II; other site 507522012570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012571 asparagine synthetase B; Provisional; Region: asnB; PRK09431 507522012572 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 507522012573 active site 507522012574 dimer interface [polypeptide binding]; other site 507522012575 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 507522012576 Ligand Binding Site [chemical binding]; other site 507522012577 Molecular Tunnel; other site 507522012578 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 507522012579 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 507522012580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522012581 FeS/SAM binding site; other site 507522012582 TRAM domain; Region: TRAM; pfam01938 507522012583 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 507522012584 PhoH-like protein; Region: PhoH; pfam02562 507522012585 metal-binding heat shock protein; Provisional; Region: PRK00016 507522012586 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 507522012587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 507522012588 Transporter associated domain; Region: CorC_HlyC; smart01091 507522012589 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 507522012590 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 507522012591 putative active site [active] 507522012592 catalytic triad [active] 507522012593 putative dimer interface [polypeptide binding]; other site 507522012594 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 507522012595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522012596 substrate binding pocket [chemical binding]; other site 507522012597 membrane-bound complex binding site; other site 507522012598 hinge residues; other site 507522012599 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522012600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012601 dimer interface [polypeptide binding]; other site 507522012602 conserved gate region; other site 507522012603 putative PBP binding loops; other site 507522012604 ABC-ATPase subunit interface; other site 507522012605 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522012606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012607 dimer interface [polypeptide binding]; other site 507522012608 conserved gate region; other site 507522012609 putative PBP binding loops; other site 507522012610 ABC-ATPase subunit interface; other site 507522012611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522012612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522012613 Walker A/P-loop; other site 507522012614 ATP binding site [chemical binding]; other site 507522012615 Q-loop/lid; other site 507522012616 ABC transporter signature motif; other site 507522012617 Walker B; other site 507522012618 D-loop; other site 507522012619 H-loop/switch region; other site 507522012620 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 507522012621 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 507522012622 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 507522012623 haemagglutination activity domain; Region: Haemagg_act; pfam05860 507522012624 hypothetical protein; Provisional; Region: PRK11032 507522012625 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 507522012626 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 507522012627 HIGH motif; other site 507522012628 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 507522012629 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 507522012630 active site 507522012631 KMSKS motif; other site 507522012632 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 507522012633 tRNA binding surface [nucleotide binding]; other site 507522012634 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 507522012635 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 507522012636 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 507522012637 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 507522012638 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 507522012639 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 507522012640 active site 507522012641 (T/H)XGH motif; other site 507522012642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 507522012643 catalytic core [active] 507522012644 ribosome-associated protein; Provisional; Region: PRK11538 507522012645 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 507522012646 penicillin-binding protein 2; Provisional; Region: PRK10795 507522012647 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 507522012648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 507522012649 cell wall shape-determining protein; Provisional; Region: PRK10794 507522012650 rare lipoprotein A; Provisional; Region: PRK10672 507522012651 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 507522012652 Sporulation related domain; Region: SPOR; pfam05036 507522012653 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 507522012654 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 507522012655 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 507522012656 hypothetical protein; Provisional; Region: PRK04998 507522012657 lipoate-protein ligase B; Provisional; Region: PRK14342 507522012658 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 507522012659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522012660 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 507522012661 substrate binding pocket [chemical binding]; other site 507522012662 dimerization interface [polypeptide binding]; other site 507522012663 lipoyl synthase; Provisional; Region: PRK05481 507522012664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522012665 FeS/SAM binding site; other site 507522012666 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 507522012667 Predicted amidohydrolase [General function prediction only]; Region: COG0388 507522012668 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 507522012669 putative active site [active] 507522012670 catalytic triad [active] 507522012671 putative dimer interface [polypeptide binding]; other site 507522012672 chromosome condensation membrane protein; Provisional; Region: PRK14196 507522012673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522012674 DNA-binding site [nucleotide binding]; DNA binding site 507522012675 RNA-binding motif; other site 507522012676 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 507522012677 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 507522012678 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 507522012679 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 507522012680 B1 nucleotide binding pocket [chemical binding]; other site 507522012681 B2 nucleotide binding pocket [chemical binding]; other site 507522012682 CAS motifs; other site 507522012683 active site 507522012684 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 507522012685 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 507522012686 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 507522012687 Ligand Binding Site [chemical binding]; other site 507522012688 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 507522012689 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 507522012690 catalytic residue [active] 507522012691 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 507522012692 catalytic residues [active] 507522012693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522012694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522012695 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 507522012696 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 507522012697 dimer interface [polypeptide binding]; other site 507522012698 decamer (pentamer of dimers) interface [polypeptide binding]; other site 507522012699 catalytic triad [active] 507522012700 peroxidatic and resolving cysteines [active] 507522012701 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 507522012702 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 507522012703 dimerization domain [polypeptide binding]; other site 507522012704 dimer interface [polypeptide binding]; other site 507522012705 catalytic residues [active] 507522012706 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 507522012707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522012708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522012709 dimerization interface [polypeptide binding]; other site 507522012710 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 507522012711 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 507522012712 Active Sites [active] 507522012713 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 507522012714 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 507522012715 ParB-like nuclease domain; Region: ParBc; pfam02195 507522012716 methionine aminotransferase; Validated; Region: PRK09082 507522012717 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522012718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522012719 homodimer interface [polypeptide binding]; other site 507522012720 catalytic residue [active] 507522012721 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 507522012722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522012723 motif II; other site 507522012724 ARD/ARD' family; Region: ARD; pfam03079 507522012725 Cupin domain; Region: Cupin_2; cl17218 507522012726 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 507522012727 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 507522012728 molybdopterin cofactor binding site [chemical binding]; other site 507522012729 substrate binding site [chemical binding]; other site 507522012730 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 507522012731 molybdopterin cofactor binding site; other site 507522012732 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 507522012733 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 507522012734 putative ligand binding site [chemical binding]; other site 507522012735 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522012736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522012737 Walker A/P-loop; other site 507522012738 ATP binding site [chemical binding]; other site 507522012739 Q-loop/lid; other site 507522012740 ABC transporter signature motif; other site 507522012741 Walker B; other site 507522012742 D-loop; other site 507522012743 H-loop/switch region; other site 507522012744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522012745 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522012746 TM-ABC transporter signature motif; other site 507522012747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522012748 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522012749 TM-ABC transporter signature motif; other site 507522012750 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522012751 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 507522012752 substrate binding site [chemical binding]; other site 507522012753 ATP binding site [chemical binding]; other site 507522012754 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 507522012755 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 507522012756 putative ligand binding site [chemical binding]; other site 507522012757 putative NAD binding site [chemical binding]; other site 507522012758 catalytic site [active] 507522012759 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 507522012760 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 507522012761 putative N- and C-terminal domain interface [polypeptide binding]; other site 507522012762 putative active site [active] 507522012763 MgATP binding site [chemical binding]; other site 507522012764 catalytic site [active] 507522012765 metal binding site [ion binding]; metal-binding site 507522012766 putative xylulose binding site [chemical binding]; other site 507522012767 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 507522012768 intersubunit interface [polypeptide binding]; other site 507522012769 active site 507522012770 Zn2+ binding site [ion binding]; other site 507522012771 cytosine permease; Provisional; Region: codB; PRK11017 507522012772 Na binding site [ion binding]; other site 507522012773 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 507522012774 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 507522012775 cytosine deaminase; Provisional; Region: PRK09230 507522012776 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 507522012777 active site 507522012778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522012779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522012780 DNA binding site [nucleotide binding] 507522012781 domain linker motif; other site 507522012782 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 507522012783 putative dimerization interface [polypeptide binding]; other site 507522012784 putative ligand binding site [chemical binding]; other site 507522012785 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 507522012786 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 507522012787 active site 507522012788 dimerization interface [polypeptide binding]; other site 507522012789 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 507522012790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012791 putative substrate translocation pore; other site 507522012792 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 507522012793 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 507522012794 catalytic core [active] 507522012795 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 507522012796 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 507522012797 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 507522012798 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 507522012799 Uncharacterized conserved protein [Function unknown]; Region: COG5276 507522012800 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 507522012801 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 507522012802 putative ligand binding site [chemical binding]; other site 507522012803 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522012804 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522012805 TM-ABC transporter signature motif; other site 507522012806 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522012807 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522012808 Walker A/P-loop; other site 507522012809 ATP binding site [chemical binding]; other site 507522012810 Q-loop/lid; other site 507522012811 ABC transporter signature motif; other site 507522012812 Walker B; other site 507522012813 D-loop; other site 507522012814 H-loop/switch region; other site 507522012815 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522012816 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 507522012817 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 507522012818 putative active site [active] 507522012819 metal binding site [ion binding]; metal-binding site 507522012820 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 507522012821 classical (c) SDRs; Region: SDR_c; cd05233 507522012822 NAD(P) binding site [chemical binding]; other site 507522012823 active site 507522012824 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 507522012825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522012826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522012827 salt bridge; other site 507522012828 non-specific DNA binding site [nucleotide binding]; other site 507522012829 sequence-specific DNA binding site [nucleotide binding]; other site 507522012830 Uncharacterized small protein [Function unknown]; Region: COG2879 507522012831 carbon starvation protein A; Provisional; Region: PRK15015 507522012832 Carbon starvation protein CstA; Region: CstA; pfam02554 507522012833 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 507522012834 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 507522012835 CoenzymeA binding site [chemical binding]; other site 507522012836 subunit interaction site [polypeptide binding]; other site 507522012837 PHB binding site; other site 507522012838 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 507522012839 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 507522012840 putative NAD(P) binding site [chemical binding]; other site 507522012841 active site 507522012842 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 507522012843 hydrophobic substrate binding pocket; other site 507522012844 Isochorismatase family; Region: Isochorismatase; pfam00857 507522012845 active site 507522012846 conserved cis-peptide bond; other site 507522012847 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 507522012848 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 507522012849 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 507522012850 acyl-activating enzyme (AAE) consensus motif; other site 507522012851 active site 507522012852 AMP binding site [chemical binding]; other site 507522012853 substrate binding site [chemical binding]; other site 507522012854 isochorismate synthase EntC; Provisional; Region: PRK15016 507522012855 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 507522012856 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 507522012857 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 507522012858 siderophore binding site; other site 507522012859 enterobactin exporter EntS; Provisional; Region: PRK10489 507522012860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522012861 putative substrate translocation pore; other site 507522012862 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522012863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522012864 ABC-ATPase subunit interface; other site 507522012865 dimer interface [polypeptide binding]; other site 507522012866 putative PBP binding regions; other site 507522012867 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 507522012868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522012869 ABC-ATPase subunit interface; other site 507522012870 dimer interface [polypeptide binding]; other site 507522012871 putative PBP binding regions; other site 507522012872 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 507522012873 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522012874 Walker A/P-loop; other site 507522012875 ATP binding site [chemical binding]; other site 507522012876 Q-loop/lid; other site 507522012877 ABC transporter signature motif; other site 507522012878 Walker B; other site 507522012879 D-loop; other site 507522012880 H-loop/switch region; other site 507522012881 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 507522012882 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 507522012883 acyl-activating enzyme (AAE) consensus motif; other site 507522012884 AMP binding site [chemical binding]; other site 507522012885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 507522012886 MbtH-like protein; Region: MbtH; cl01279 507522012887 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 507522012888 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 507522012889 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 507522012890 outer membrane receptor FepA; Provisional; Region: PRK13524 507522012891 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522012892 N-terminal plug; other site 507522012893 ligand-binding site [chemical binding]; other site 507522012894 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 507522012895 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 507522012896 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 507522012897 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522012898 PYR/PP interface [polypeptide binding]; other site 507522012899 dimer interface [polypeptide binding]; other site 507522012900 TPP binding site [chemical binding]; other site 507522012901 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522012902 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 507522012903 TPP-binding site [chemical binding]; other site 507522012904 dimer interface [polypeptide binding]; other site 507522012905 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 507522012906 MarR family; Region: MarR_2; cl17246 507522012907 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 507522012908 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 507522012909 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 507522012910 N- and C-terminal domain interface [polypeptide binding]; other site 507522012911 active site 507522012912 MgATP binding site [chemical binding]; other site 507522012913 catalytic site [active] 507522012914 metal binding site [ion binding]; metal-binding site 507522012915 putative homotetramer interface [polypeptide binding]; other site 507522012916 putative homodimer interface [polypeptide binding]; other site 507522012917 glycerol binding site [chemical binding]; other site 507522012918 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 507522012919 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 507522012920 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 507522012921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522012922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522012923 Walker A/P-loop; other site 507522012924 ATP binding site [chemical binding]; other site 507522012925 Q-loop/lid; other site 507522012926 ABC transporter signature motif; other site 507522012927 Walker B; other site 507522012928 D-loop; other site 507522012929 H-loop/switch region; other site 507522012930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522012931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522012932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522012933 TM-ABC transporter signature motif; other site 507522012934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522012935 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 507522012936 NAD binding site [chemical binding]; other site 507522012937 homotetramer interface [polypeptide binding]; other site 507522012938 homodimer interface [polypeptide binding]; other site 507522012939 active site 507522012940 substrate binding site [chemical binding]; other site 507522012941 short chain dehydrogenase; Provisional; Region: PRK06114 507522012942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522012943 NAD(P) binding site [chemical binding]; other site 507522012944 active site 507522012945 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522012946 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 507522012947 C-terminal domain interface [polypeptide binding]; other site 507522012948 GSH binding site (G-site) [chemical binding]; other site 507522012949 dimer interface [polypeptide binding]; other site 507522012950 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 507522012951 N-terminal domain interface [polypeptide binding]; other site 507522012952 dimer interface [polypeptide binding]; other site 507522012953 substrate binding pocket (H-site) [chemical binding]; other site 507522012954 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 507522012955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522012956 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 507522012957 dimerization interface [polypeptide binding]; other site 507522012958 substrate binding pocket [chemical binding]; other site 507522012959 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 507522012960 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522012961 C-lysozyme inhibitor; Provisional; Region: PRK09993 507522012962 choline transport protein BetT; Provisional; Region: PRK09928 507522012963 transcriptional regulator BetI; Validated; Region: PRK00767 507522012964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522012965 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 507522012966 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 507522012967 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 507522012968 tetrameric interface [polypeptide binding]; other site 507522012969 NAD binding site [chemical binding]; other site 507522012970 catalytic residues [active] 507522012971 choline dehydrogenase; Validated; Region: PRK02106 507522012972 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 507522012973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 507522012974 YheO-like PAS domain; Region: PAS_6; pfam08348 507522012975 HTH domain; Region: HTH_22; pfam13309 507522012976 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 507522012977 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 507522012978 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 507522012979 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 507522012980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522012981 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 507522012982 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 507522012983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522012984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012985 dimer interface [polypeptide binding]; other site 507522012986 conserved gate region; other site 507522012987 putative PBP binding loops; other site 507522012988 ABC-ATPase subunit interface; other site 507522012989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 507522012990 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 507522012991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522012992 dimer interface [polypeptide binding]; other site 507522012993 conserved gate region; other site 507522012994 ABC-ATPase subunit interface; other site 507522012995 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 507522012996 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522012997 Walker A/P-loop; other site 507522012998 ATP binding site [chemical binding]; other site 507522012999 Q-loop/lid; other site 507522013000 ABC transporter signature motif; other site 507522013001 Walker B; other site 507522013002 D-loop; other site 507522013003 H-loop/switch region; other site 507522013004 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 507522013005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522013006 Walker A/P-loop; other site 507522013007 ATP binding site [chemical binding]; other site 507522013008 Q-loop/lid; other site 507522013009 ABC transporter signature motif; other site 507522013010 Walker B; other site 507522013011 D-loop; other site 507522013012 H-loop/switch region; other site 507522013013 hypothetical protein; Provisional; Region: PRK06062 507522013014 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522013015 inhibitor-cofactor binding pocket; inhibition site 507522013016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013017 catalytic residue [active] 507522013018 malonic semialdehyde reductase; Provisional; Region: PRK10538 507522013019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522013020 NAD(P) binding site [chemical binding]; other site 507522013021 active site 507522013022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522013023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522013024 Walker A/P-loop; other site 507522013025 ATP binding site [chemical binding]; other site 507522013026 Q-loop/lid; other site 507522013027 ABC transporter signature motif; other site 507522013028 Walker B; other site 507522013029 D-loop; other site 507522013030 H-loop/switch region; other site 507522013031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013032 dimer interface [polypeptide binding]; other site 507522013033 conserved gate region; other site 507522013034 putative PBP binding loops; other site 507522013035 ABC-ATPase subunit interface; other site 507522013036 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 507522013037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013038 dimer interface [polypeptide binding]; other site 507522013039 conserved gate region; other site 507522013040 putative PBP binding loops; other site 507522013041 ABC-ATPase subunit interface; other site 507522013042 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522013043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522013044 substrate binding pocket [chemical binding]; other site 507522013045 membrane-bound complex binding site; other site 507522013046 hinge residues; other site 507522013047 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522013048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522013049 DNA-binding site [nucleotide binding]; DNA binding site 507522013050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522013051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013052 homodimer interface [polypeptide binding]; other site 507522013053 catalytic residue [active] 507522013054 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522013055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522013056 DNA-binding site [nucleotide binding]; DNA binding site 507522013057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522013058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013059 homodimer interface [polypeptide binding]; other site 507522013060 catalytic residue [active] 507522013061 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 507522013062 EamA-like transporter family; Region: EamA; pfam00892 507522013063 allantoate amidohydrolase; Reviewed; Region: PRK12893 507522013064 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 507522013065 active site 507522013066 metal binding site [ion binding]; metal-binding site 507522013067 dimer interface [polypeptide binding]; other site 507522013068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 507522013069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522013070 Walker A/P-loop; other site 507522013071 ATP binding site [chemical binding]; other site 507522013072 Q-loop/lid; other site 507522013073 ABC transporter signature motif; other site 507522013074 Walker B; other site 507522013075 D-loop; other site 507522013076 H-loop/switch region; other site 507522013077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522013078 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 507522013079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522013080 Walker A/P-loop; other site 507522013081 ATP binding site [chemical binding]; other site 507522013082 Q-loop/lid; other site 507522013083 ABC transporter signature motif; other site 507522013084 Walker B; other site 507522013085 D-loop; other site 507522013086 H-loop/switch region; other site 507522013087 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 507522013088 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 507522013089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522013090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 507522013091 Protein of unknown function (DUF419); Region: DUF419; cl15265 507522013092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013093 dimer interface [polypeptide binding]; other site 507522013094 conserved gate region; other site 507522013095 putative PBP binding loops; other site 507522013096 ABC-ATPase subunit interface; other site 507522013097 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 507522013098 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 507522013099 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 507522013100 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 507522013101 Predicted periplasmic protein [Function unknown]; Region: COG3698 507522013102 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 507522013103 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 507522013104 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 507522013105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522013106 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522013107 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 507522013108 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 507522013109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522013110 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 507522013111 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 507522013112 Soluble P-type ATPase [General function prediction only]; Region: COG4087 507522013113 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 507522013114 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 507522013115 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 507522013116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522013117 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 507522013118 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 507522013119 hypothetical protein; Provisional; Region: PRK10250 507522013120 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 507522013121 dimer interface [polypeptide binding]; other site 507522013122 FMN binding site [chemical binding]; other site 507522013123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522013124 non-specific DNA binding site [nucleotide binding]; other site 507522013125 salt bridge; other site 507522013126 sequence-specific DNA binding site [nucleotide binding]; other site 507522013127 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 507522013128 Helix-turn-helix domain; Region: HTH_31; pfam13560 507522013129 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 507522013130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013131 putative substrate translocation pore; other site 507522013132 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 507522013133 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522013134 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522013135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522013136 DNA binding site [nucleotide binding] 507522013137 domain linker motif; other site 507522013138 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 507522013139 dimerization interface [polypeptide binding]; other site 507522013140 ligand binding site [chemical binding]; other site 507522013141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522013142 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522013143 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522013144 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 507522013145 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 507522013146 Metal-binding active site; metal-binding site 507522013147 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 507522013148 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 507522013149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013150 putative substrate translocation pore; other site 507522013151 phenylalanine transporter; Provisional; Region: PRK10249 507522013152 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 507522013153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522013154 N-terminal plug; other site 507522013155 ligand-binding site [chemical binding]; other site 507522013156 PQQ-like domain; Region: PQQ_2; pfam13360 507522013157 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 507522013158 active site 507522013159 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 507522013160 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 507522013161 NAD(P) binding site [chemical binding]; other site 507522013162 catalytic residues [active] 507522013163 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 507522013164 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 507522013165 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 507522013166 Amino acid permease; Region: AA_permease_2; pfam13520 507522013167 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 507522013168 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 507522013169 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 507522013170 active site 507522013171 Zn binding site [ion binding]; other site 507522013172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013173 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522013174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522013175 DNA binding residues [nucleotide binding] 507522013176 dimerization interface [polypeptide binding]; other site 507522013177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 507522013178 classical (c) SDRs; Region: SDR_c; cd05233 507522013179 NAD(P) binding site [chemical binding]; other site 507522013180 active site 507522013181 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 507522013182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522013183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522013184 active site 507522013185 catalytic tetrad [active] 507522013186 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 507522013187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522013188 substrate binding pocket [chemical binding]; other site 507522013189 membrane-bound complex binding site; other site 507522013190 hinge residues; other site 507522013191 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522013192 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 507522013193 metal binding site [ion binding]; metal-binding site 507522013194 putative dimer interface [polypeptide binding]; other site 507522013195 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 507522013196 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 507522013197 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 507522013198 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 507522013199 intersubunit interface [polypeptide binding]; other site 507522013200 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522013201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522013202 ABC-ATPase subunit interface; other site 507522013203 dimer interface [polypeptide binding]; other site 507522013204 putative PBP binding regions; other site 507522013205 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 507522013206 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522013207 Walker A/P-loop; other site 507522013208 ATP binding site [chemical binding]; other site 507522013209 Q-loop/lid; other site 507522013210 ABC transporter signature motif; other site 507522013211 Walker B; other site 507522013212 D-loop; other site 507522013213 H-loop/switch region; other site 507522013214 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 507522013215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522013216 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522013217 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 507522013218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 507522013219 Transcriptional regulator; Region: Rrf2; cl17282 507522013220 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522013221 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 507522013222 putative substrate binding site [chemical binding]; other site 507522013223 putative ATP binding site [chemical binding]; other site 507522013224 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522013225 trimer interface; other site 507522013226 sugar binding site [chemical binding]; other site 507522013227 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 507522013228 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522013229 active site turn [active] 507522013230 phosphorylation site [posttranslational modification] 507522013231 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522013232 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 507522013233 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 507522013234 substrate binding [chemical binding]; other site 507522013235 active site 507522013236 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 507522013237 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 507522013238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522013239 DNA binding site [nucleotide binding] 507522013240 domain linker motif; other site 507522013241 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 507522013242 dimerization interface [polypeptide binding]; other site 507522013243 ligand binding site [chemical binding]; other site 507522013244 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522013245 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522013246 TM-ABC transporter signature motif; other site 507522013247 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522013248 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522013249 Walker A/P-loop; other site 507522013250 ATP binding site [chemical binding]; other site 507522013251 Q-loop/lid; other site 507522013252 ABC transporter signature motif; other site 507522013253 Walker B; other site 507522013254 D-loop; other site 507522013255 H-loop/switch region; other site 507522013256 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522013257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522013258 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 507522013259 putative ligand binding site [chemical binding]; other site 507522013260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522013261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522013262 DNA binding site [nucleotide binding] 507522013263 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 507522013264 putative ligand binding site [chemical binding]; other site 507522013265 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522013266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522013267 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522013268 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522013269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522013270 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522013271 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522013272 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 507522013273 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 507522013274 Metal-binding active site; metal-binding site 507522013275 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 507522013276 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 507522013277 dimer interface [polypeptide binding]; other site 507522013278 putative anticodon binding site; other site 507522013279 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 507522013280 motif 1; other site 507522013281 active site 507522013282 motif 2; other site 507522013283 motif 3; other site 507522013284 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 507522013285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013286 putative substrate translocation pore; other site 507522013287 POT family; Region: PTR2; pfam00854 507522013288 lysine decarboxylase CadA; Provisional; Region: PRK15400 507522013289 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 507522013290 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 507522013291 homodimer interface [polypeptide binding]; other site 507522013292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013293 catalytic residue [active] 507522013294 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 507522013295 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 507522013296 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 507522013297 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 507522013298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522013299 DNA binding site [nucleotide binding] 507522013300 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522013301 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 507522013302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 507522013303 putative acyl-acceptor binding pocket; other site 507522013304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522013305 Coenzyme A binding pocket [chemical binding]; other site 507522013306 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522013307 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522013308 PapC N-terminal domain; Region: PapC_N; pfam13954 507522013309 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522013310 PapC C-terminal domain; Region: PapC_C; pfam13953 507522013311 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522013312 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522013313 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522013314 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 507522013315 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 507522013316 DNA binding residues [nucleotide binding] 507522013317 dimerization interface [polypeptide binding]; other site 507522013318 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 507522013319 dimer interface [polypeptide binding]; other site 507522013320 Citrate synthase; Region: Citrate_synt; pfam00285 507522013321 active site 507522013322 citrylCoA binding site [chemical binding]; other site 507522013323 NADH binding [chemical binding]; other site 507522013324 cationic pore residues; other site 507522013325 oxalacetate/citrate binding site [chemical binding]; other site 507522013326 coenzyme A binding site [chemical binding]; other site 507522013327 catalytic triad [active] 507522013328 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 507522013329 active site 507522013330 homotetramer interface [polypeptide binding]; other site 507522013331 haemagglutination activity domain; Region: Haemagg_act; pfam05860 507522013332 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 507522013333 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 507522013334 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 507522013335 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 507522013336 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 507522013337 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 507522013338 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 507522013339 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 507522013340 PHAGE02; KPK_5615 507522013341 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 507522013342 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 507522013343 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 507522013344 Mnt; Region: mnt; PHA01513 507522013345 Arc-like DNA binding domain; Region: Arc; pfam03869 507522013346 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 507522013347 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 507522013348 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522013349 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522013350 catalytic residue [active] 507522013351 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 507522013352 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 507522013353 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 507522013354 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 507522013355 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 507522013356 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 507522013357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 507522013358 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 507522013359 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 507522013360 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 507522013361 catalytic residues [active] 507522013362 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 507522013363 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 507522013364 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 507522013365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522013366 active site 507522013367 metal binding site [ion binding]; metal-binding site 507522013368 prophage protein NinE; Provisional; Region: PRK09689 507522013369 NinB protein; Region: NinB; pfam05772 507522013370 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 507522013371 Protein of unknown function (DUF551); Region: DUF551; pfam04448 507522013372 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 507522013373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 507522013374 putative Zn2+ binding site [ion binding]; other site 507522013375 putative DNA binding site [nucleotide binding]; other site 507522013376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522013377 Walker A motif; other site 507522013378 ATP binding site [chemical binding]; other site 507522013379 Walker B motif; other site 507522013380 arginine finger; other site 507522013381 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 507522013382 Bacteriophage CII protein; Region: Phage_CII; pfam05269 507522013383 Cro; Region: Cro; pfam09048 507522013384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 507522013385 non-specific DNA binding site [nucleotide binding]; other site 507522013386 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 507522013387 salt bridge; other site 507522013388 sequence-specific DNA binding site [nucleotide binding]; other site 507522013389 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 507522013390 Catalytic site [active] 507522013391 ERF superfamily; Region: ERF; pfam04404 507522013392 Helix-turn-helix domain; Region: HTH_38; pfam13936 507522013393 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 507522013394 MT-A70; Region: MT-A70; cl01947 507522013395 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 507522013396 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 507522013397 cofactor binding site; other site 507522013398 DNA binding site [nucleotide binding] 507522013399 substrate interaction site [chemical binding]; other site 507522013400 DksA-like zinc finger domain containing protein; Region: PHA00080 507522013401 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 507522013402 Helix-turn-helix domain; Region: HTH_17; pfam12728 507522013403 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 507522013404 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 507522013405 Int/Topo IB signature motif; other site 507522013406 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 507522013407 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 507522013408 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 507522013409 homodimer interface [polypeptide binding]; other site 507522013410 NADP binding site [chemical binding]; other site 507522013411 substrate binding site [chemical binding]; other site 507522013412 ribosome-associated protein; Provisional; Region: PRK11507 507522013413 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 507522013414 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 507522013415 active site 507522013416 HIGH motif; other site 507522013417 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 507522013418 KMSKS motif; other site 507522013419 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 507522013420 tRNA binding surface [nucleotide binding]; other site 507522013421 anticodon binding site; other site 507522013422 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 507522013423 substrate binding site [chemical binding]; other site 507522013424 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 507522013425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522013426 putative active site [active] 507522013427 putative metal binding site [ion binding]; other site 507522013428 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 507522013429 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 507522013430 ATP-grasp domain; Region: ATP-grasp; pfam02222 507522013431 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 507522013432 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 507522013433 active site residue [active] 507522013434 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522013435 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 507522013436 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 507522013437 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 507522013438 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 507522013439 Walker A/P-loop; other site 507522013440 ATP binding site [chemical binding]; other site 507522013441 Q-loop/lid; other site 507522013442 ABC transporter signature motif; other site 507522013443 Walker B; other site 507522013444 D-loop; other site 507522013445 H-loop/switch region; other site 507522013446 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 507522013447 active site 507522013448 catalytic triad [active] 507522013449 oxyanion hole [active] 507522013450 switch loop; other site 507522013451 oxidoreductase; Provisional; Region: PRK08017 507522013452 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 507522013453 NADP binding site [chemical binding]; other site 507522013454 active site 507522013455 steroid binding site; other site 507522013456 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 507522013457 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 507522013458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 507522013459 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 507522013460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522013461 Walker A/P-loop; other site 507522013462 ATP binding site [chemical binding]; other site 507522013463 Q-loop/lid; other site 507522013464 ABC transporter signature motif; other site 507522013465 Walker B; other site 507522013466 D-loop; other site 507522013467 H-loop/switch region; other site 507522013468 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 507522013469 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 507522013470 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 507522013471 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 507522013472 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 507522013473 DNA binding residues [nucleotide binding] 507522013474 dimer interface [polypeptide binding]; other site 507522013475 copper binding site [ion binding]; other site 507522013476 copper exporting ATPase; Provisional; Region: copA; PRK10671 507522013477 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 507522013478 metal-binding site [ion binding] 507522013479 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 507522013480 metal-binding site [ion binding] 507522013481 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522013482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522013483 motif II; other site 507522013484 TraB family; Region: TraB; cl12050 507522013485 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 507522013486 putative deacylase active site [active] 507522013487 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 507522013488 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 507522013489 active site 507522013490 metal binding site [ion binding]; metal-binding site 507522013491 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 507522013492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522013494 putative substrate translocation pore; other site 507522013495 putative cation:proton antiport protein; Provisional; Region: PRK10669 507522013496 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 507522013497 TrkA-N domain; Region: TrkA_N; pfam02254 507522013498 inosine/guanosine kinase; Provisional; Region: PRK15074 507522013499 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522013500 ferrochelatase; Reviewed; Region: hemH; PRK00035 507522013501 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 507522013502 C-terminal domain interface [polypeptide binding]; other site 507522013503 active site 507522013504 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 507522013505 active site 507522013506 N-terminal domain interface [polypeptide binding]; other site 507522013507 adenylate kinase; Reviewed; Region: adk; PRK00279 507522013508 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 507522013509 AMP-binding site [chemical binding]; other site 507522013510 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 507522013511 heat shock protein 90; Provisional; Region: PRK05218 507522013512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522013513 ATP binding site [chemical binding]; other site 507522013514 Mg2+ binding site [ion binding]; other site 507522013515 G-X-G motif; other site 507522013516 recombination protein RecR; Reviewed; Region: recR; PRK00076 507522013517 RecR protein; Region: RecR; pfam02132 507522013518 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 507522013519 putative active site [active] 507522013520 putative metal-binding site [ion binding]; other site 507522013521 tetramer interface [polypeptide binding]; other site 507522013522 hypothetical protein; Validated; Region: PRK00153 507522013523 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 507522013524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522013525 Walker A motif; other site 507522013526 ATP binding site [chemical binding]; other site 507522013527 Walker B motif; other site 507522013528 arginine finger; other site 507522013529 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 507522013530 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 507522013531 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 507522013532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522013533 active site 507522013534 hypothetical protein; Provisional; Region: PRK10527 507522013535 primosomal replication protein N''; Provisional; Region: PRK10093 507522013536 hypothetical protein; Provisional; Region: PRK11038 507522013537 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 507522013538 hypothetical protein; Provisional; Region: PRK11281 507522013539 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 507522013540 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 507522013541 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 507522013542 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522013543 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 507522013544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522013545 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 507522013546 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 507522013547 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522013548 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 507522013549 Protein export membrane protein; Region: SecD_SecF; cl14618 507522013550 Hha toxicity attenuator; Provisional; Region: PRK10667 507522013551 gene expression modulator; Provisional; Region: PRK10945 507522013552 maltose O-acetyltransferase; Provisional; Region: PRK10092 507522013553 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 507522013554 active site 507522013555 substrate binding site [chemical binding]; other site 507522013556 trimer interface [polypeptide binding]; other site 507522013557 CoA binding site [chemical binding]; other site 507522013558 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 507522013559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522013560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522013561 DNA-binding site [nucleotide binding]; DNA binding site 507522013562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522013563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013564 homodimer interface [polypeptide binding]; other site 507522013565 catalytic residue [active] 507522013566 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 507522013567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522013568 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 507522013569 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 507522013570 lac repressor; Reviewed; Region: lacI; PRK09526 507522013571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522013572 DNA binding site [nucleotide binding] 507522013573 domain linker motif; other site 507522013574 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 507522013575 ligand binding site [chemical binding]; other site 507522013576 dimerization interface (open form) [polypeptide binding]; other site 507522013577 dimerization interface (closed form) [polypeptide binding]; other site 507522013578 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522013579 trimer interface; other site 507522013580 sugar binding site [chemical binding]; other site 507522013581 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522013582 active site turn [active] 507522013583 phosphorylation site [posttranslational modification] 507522013584 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 507522013585 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 507522013586 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 507522013587 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 507522013588 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 507522013589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522013590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013591 dimer interface [polypeptide binding]; other site 507522013592 conserved gate region; other site 507522013593 putative PBP binding loops; other site 507522013594 ABC-ATPase subunit interface; other site 507522013595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013596 dimer interface [polypeptide binding]; other site 507522013597 conserved gate region; other site 507522013598 ABC-ATPase subunit interface; other site 507522013599 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 507522013600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 507522013601 DAK2 domain; Region: Dak2; cl03685 507522013602 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 507522013603 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 507522013604 Walker A/P-loop; other site 507522013605 ATP binding site [chemical binding]; other site 507522013606 Q-loop/lid; other site 507522013607 ABC transporter signature motif; other site 507522013608 Walker B; other site 507522013609 D-loop; other site 507522013610 H-loop/switch region; other site 507522013611 TOBE domain; Region: TOBE_2; pfam08402 507522013612 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 507522013613 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 507522013614 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522013615 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 507522013616 putative metal binding site [ion binding]; other site 507522013617 putative homodimer interface [polypeptide binding]; other site 507522013618 putative homotetramer interface [polypeptide binding]; other site 507522013619 putative homodimer-homodimer interface [polypeptide binding]; other site 507522013620 putative allosteric switch controlling residues; other site 507522013621 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 507522013622 Predicted membrane protein [Function unknown]; Region: COG2364 507522013623 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 507522013624 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 507522013625 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522013626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522013627 DNA-binding site [nucleotide binding]; DNA binding site 507522013628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522013629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522013630 homodimer interface [polypeptide binding]; other site 507522013631 catalytic residue [active] 507522013632 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 507522013633 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 507522013634 DNA binding site [nucleotide binding] 507522013635 active site 507522013636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 507522013637 acyl-CoA thioesterase II; Provisional; Region: PRK10526 507522013638 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 507522013639 active site 507522013640 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 507522013641 catalytic triad [active] 507522013642 dimer interface [polypeptide binding]; other site 507522013643 ammonium transporter; Provisional; Region: PRK10666 507522013644 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 507522013645 Nitrogen regulatory protein P-II; Region: P-II; smart00938 507522013646 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 507522013647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522013648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522013649 Walker A/P-loop; other site 507522013650 ATP binding site [chemical binding]; other site 507522013651 Q-loop/lid; other site 507522013652 ABC transporter signature motif; other site 507522013653 Walker B; other site 507522013654 D-loop; other site 507522013655 H-loop/switch region; other site 507522013656 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 507522013657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522013658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522013659 Walker A/P-loop; other site 507522013660 ATP binding site [chemical binding]; other site 507522013661 Q-loop/lid; other site 507522013662 ABC transporter signature motif; other site 507522013663 Walker B; other site 507522013664 D-loop; other site 507522013665 H-loop/switch region; other site 507522013666 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 507522013667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522013668 putative DNA binding site [nucleotide binding]; other site 507522013669 putative Zn2+ binding site [ion binding]; other site 507522013670 AsnC family; Region: AsnC_trans_reg; pfam01037 507522013671 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 507522013672 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 507522013673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522013674 catalytic residue [active] 507522013675 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 507522013676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522013677 active site 507522013678 motif I; other site 507522013679 motif II; other site 507522013680 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 507522013681 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 507522013682 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 507522013683 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 507522013684 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 507522013685 Ligand Binding Site [chemical binding]; other site 507522013686 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 507522013687 active site 507522013688 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 507522013689 periplasmic folding chaperone; Provisional; Region: PRK10788 507522013690 SurA N-terminal domain; Region: SurA_N_3; cl07813 507522013691 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 507522013692 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 507522013693 IHF dimer interface [polypeptide binding]; other site 507522013694 IHF - DNA interface [nucleotide binding]; other site 507522013695 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 507522013696 Found in ATP-dependent protease La (LON); Region: LON; smart00464 507522013697 Found in ATP-dependent protease La (LON); Region: LON; smart00464 507522013698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522013699 Walker A motif; other site 507522013700 ATP binding site [chemical binding]; other site 507522013701 Walker B motif; other site 507522013702 arginine finger; other site 507522013703 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 507522013704 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 507522013705 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 507522013706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522013707 Walker A motif; other site 507522013708 ATP binding site [chemical binding]; other site 507522013709 Walker B motif; other site 507522013710 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 507522013711 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 507522013712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 507522013713 oligomer interface [polypeptide binding]; other site 507522013714 active site residues [active] 507522013715 trigger factor; Provisional; Region: tig; PRK01490 507522013716 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522013717 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 507522013718 transcriptional regulator BolA; Provisional; Region: PRK11628 507522013719 hypothetical protein; Provisional; Region: PRK11627 507522013720 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 507522013721 muropeptide transporter; Reviewed; Region: ampG; PRK11902 507522013722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013723 putative substrate translocation pore; other site 507522013724 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 507522013725 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 507522013726 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 507522013727 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 507522013728 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 507522013729 D-pathway; other site 507522013730 Putative ubiquinol binding site [chemical binding]; other site 507522013731 Low-spin heme (heme b) binding site [chemical binding]; other site 507522013732 Putative water exit pathway; other site 507522013733 Binuclear center (heme o3/CuB) [ion binding]; other site 507522013734 K-pathway; other site 507522013735 Putative proton exit pathway; other site 507522013736 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 507522013737 Subunit I/III interface [polypeptide binding]; other site 507522013738 Subunit III/IV interface [polypeptide binding]; other site 507522013739 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 507522013740 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 507522013741 UbiA prenyltransferase family; Region: UbiA; pfam01040 507522013742 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 507522013743 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522013744 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522013745 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 507522013746 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 507522013747 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 507522013748 shikimate binding site; other site 507522013749 NAD(P) binding site [chemical binding]; other site 507522013750 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 507522013751 NIPSNAP; Region: NIPSNAP; pfam07978 507522013752 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 507522013753 Predicted oxidoreductase [General function prediction only]; Region: COG3573 507522013754 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 507522013755 benzoate transport; Region: 2A0115; TIGR00895 507522013756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013757 putative substrate translocation pore; other site 507522013758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522013760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522013761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522013762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522013764 putative substrate translocation pore; other site 507522013765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 507522013766 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 507522013767 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 507522013768 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 507522013769 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 507522013770 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 507522013771 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 507522013772 conserved cys residue [active] 507522013773 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 507522013774 putative hydrophobic ligand binding site [chemical binding]; other site 507522013775 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 507522013776 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 507522013777 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 507522013778 Ligand Binding Site [chemical binding]; other site 507522013779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 507522013780 active site residue [active] 507522013781 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 507522013782 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 507522013783 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 507522013784 substrate binding pocket [chemical binding]; other site 507522013785 chain length determination region; other site 507522013786 substrate-Mg2+ binding site; other site 507522013787 catalytic residues [active] 507522013788 aspartate-rich region 1; other site 507522013789 active site lid residues [active] 507522013790 aspartate-rich region 2; other site 507522013791 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 507522013792 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 507522013793 TPP-binding site; other site 507522013794 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 507522013795 PYR/PP interface [polypeptide binding]; other site 507522013796 dimer interface [polypeptide binding]; other site 507522013797 TPP binding site [chemical binding]; other site 507522013798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522013799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522013800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522013801 active site 507522013802 catalytic tetrad [active] 507522013803 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 507522013804 tetramer interfaces [polypeptide binding]; other site 507522013805 binuclear metal-binding site [ion binding]; other site 507522013806 thiamine monophosphate kinase; Provisional; Region: PRK05731 507522013807 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 507522013808 ATP binding site [chemical binding]; other site 507522013809 dimerization interface [polypeptide binding]; other site 507522013810 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 507522013811 putative RNA binding site [nucleotide binding]; other site 507522013812 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 507522013813 homopentamer interface [polypeptide binding]; other site 507522013814 active site 507522013815 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 507522013816 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 507522013817 catalytic motif [active] 507522013818 Zn binding site [ion binding]; other site 507522013819 RibD C-terminal domain; Region: RibD_C; cl17279 507522013820 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 507522013821 ATP cone domain; Region: ATP-cone; pfam03477 507522013822 hypothetical protein; Provisional; Region: PRK11530 507522013823 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 507522013824 Predicted transcriptional regulator [Transcription]; Region: COG2378 507522013825 HTH domain; Region: HTH_11; pfam08279 507522013826 WYL domain; Region: WYL; pfam13280 507522013827 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 507522013828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522013829 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 507522013830 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 507522013831 Protein export membrane protein; Region: SecD_SecF; pfam02355 507522013832 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 507522013833 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 507522013834 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 507522013835 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 507522013836 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 507522013837 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 507522013838 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 507522013839 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 507522013840 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 507522013841 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 507522013842 peroxidase; Provisional; Region: PRK15000 507522013843 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 507522013844 dimer interface [polypeptide binding]; other site 507522013845 decamer (pentamer of dimers) interface [polypeptide binding]; other site 507522013846 catalytic triad [active] 507522013847 peroxidatic and resolving cysteines [active] 507522013848 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522013849 active site 507522013850 phosphorylation site [posttranslational modification] 507522013851 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 507522013852 active site 507522013853 P-loop; other site 507522013854 phosphorylation site [posttranslational modification] 507522013855 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 507522013856 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522013857 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 507522013858 substrate binding site [chemical binding]; other site 507522013859 ATP binding site [chemical binding]; other site 507522013860 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 507522013861 intersubunit interface [polypeptide binding]; other site 507522013862 active site 507522013863 zinc binding site [ion binding]; other site 507522013864 Na+ binding site [ion binding]; other site 507522013865 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 507522013866 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 507522013867 active site 507522013868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 507522013869 Isochorismatase family; Region: Isochorismatase; pfam00857 507522013870 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 507522013871 catalytic triad [active] 507522013872 dimer interface [polypeptide binding]; other site 507522013873 conserved cis-peptide bond; other site 507522013874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522013875 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 507522013876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 507522013877 dimerization interface [polypeptide binding]; other site 507522013878 maltodextrin glucosidase; Provisional; Region: PRK10785 507522013879 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 507522013880 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 507522013881 active site 507522013882 homodimer interface [polypeptide binding]; other site 507522013883 catalytic site [active] 507522013884 putative proline-specific permease; Provisional; Region: proY; PRK10580 507522013885 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 507522013886 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 507522013887 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 507522013888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522013889 putative active site [active] 507522013890 heme pocket [chemical binding]; other site 507522013891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522013892 dimer interface [polypeptide binding]; other site 507522013893 phosphorylation site [posttranslational modification] 507522013894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522013895 ATP binding site [chemical binding]; other site 507522013896 Mg2+ binding site [ion binding]; other site 507522013897 G-X-G motif; other site 507522013898 transcriptional regulator PhoB; Provisional; Region: PRK10161 507522013899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522013900 active site 507522013901 phosphorylation site [posttranslational modification] 507522013902 intermolecular recognition site; other site 507522013903 dimerization interface [polypeptide binding]; other site 507522013904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522013905 DNA binding site [nucleotide binding] 507522013906 exonuclease subunit SbcD; Provisional; Region: PRK10966 507522013907 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 507522013908 active site 507522013909 metal binding site [ion binding]; metal-binding site 507522013910 DNA binding site [nucleotide binding] 507522013911 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 507522013912 exonuclease subunit SbcC; Provisional; Region: PRK10246 507522013913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522013914 Walker A/P-loop; other site 507522013915 ATP binding site [chemical binding]; other site 507522013916 Q-loop/lid; other site 507522013917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522013918 ABC transporter signature motif; other site 507522013919 Walker B; other site 507522013920 D-loop; other site 507522013921 H-loop/switch region; other site 507522013922 fructokinase; Reviewed; Region: PRK09557 507522013923 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522013924 nucleotide binding site [chemical binding]; other site 507522013925 Acetokinase family; Region: Acetate_kinase; cl17229 507522013926 recombination associated protein; Reviewed; Region: rdgC; PRK00321 507522013927 hypothetical protein; Provisional; Region: PRK10579 507522013928 hypothetical protein; Provisional; Region: PRK10481 507522013929 hypothetical protein; Provisional; Region: PRK10380 507522013930 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 507522013931 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 507522013932 ADP binding site [chemical binding]; other site 507522013933 magnesium binding site [ion binding]; other site 507522013934 putative shikimate binding site; other site 507522013935 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 507522013936 hypothetical protein; Validated; Region: PRK00124 507522013937 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 507522013938 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 507522013939 hypothetical protein; Provisional; Region: PRK11505 507522013940 psiF repeat; Region: PsiF_repeat; pfam07769 507522013941 psiF repeat; Region: PsiF_repeat; pfam07769 507522013942 alkaline phosphatase; Provisional; Region: PRK10518 507522013943 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 507522013944 active site 507522013945 dimer interface [polypeptide binding]; other site 507522013946 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 507522013947 drug efflux system protein MdtG; Provisional; Region: PRK09874 507522013948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522013949 putative substrate translocation pore; other site 507522013950 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 507522013951 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 507522013952 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 507522013953 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 507522013954 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 507522013955 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 507522013956 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 507522013957 microcin B17 transporter; Reviewed; Region: PRK11098 507522013958 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 507522013959 Isochorismatase family; Region: Isochorismatase; pfam00857 507522013960 catalytic triad [active] 507522013961 conserved cis-peptide bond; other site 507522013962 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 507522013963 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 507522013964 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 507522013965 dimer interface [polypeptide binding]; other site 507522013966 active site 507522013967 Schiff base residues; other site 507522013968 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 507522013969 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 507522013970 putative acyl-acceptor binding pocket; other site 507522013971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 507522013972 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 507522013973 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 507522013974 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522013975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522013976 dimer interface [polypeptide binding]; other site 507522013977 conserved gate region; other site 507522013978 putative PBP binding loops; other site 507522013979 ABC-ATPase subunit interface; other site 507522013980 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 507522013981 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522013982 Walker A/P-loop; other site 507522013983 ATP binding site [chemical binding]; other site 507522013984 Q-loop/lid; other site 507522013985 ABC transporter signature motif; other site 507522013986 Walker B; other site 507522013987 D-loop; other site 507522013988 H-loop/switch region; other site 507522013989 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 507522013990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522013991 substrate binding pocket [chemical binding]; other site 507522013992 membrane-bound complex binding site; other site 507522013993 hinge residues; other site 507522013994 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 507522013995 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 507522013996 S-methylmethionine transporter; Provisional; Region: PRK11387 507522013997 ethanolamine permease; Region: 2A0305; TIGR00908 507522013998 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 507522013999 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 507522014000 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 507522014001 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 507522014002 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 507522014003 putative ligand binding site [chemical binding]; other site 507522014004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522014005 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 507522014006 TM-ABC transporter signature motif; other site 507522014007 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 507522014008 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 507522014009 TM-ABC transporter signature motif; other site 507522014010 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 507522014011 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 507522014012 Walker A/P-loop; other site 507522014013 ATP binding site [chemical binding]; other site 507522014014 Q-loop/lid; other site 507522014015 ABC transporter signature motif; other site 507522014016 Walker B; other site 507522014017 D-loop; other site 507522014018 H-loop/switch region; other site 507522014019 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 507522014020 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 507522014021 Walker A/P-loop; other site 507522014022 ATP binding site [chemical binding]; other site 507522014023 Q-loop/lid; other site 507522014024 ABC transporter signature motif; other site 507522014025 Walker B; other site 507522014026 D-loop; other site 507522014027 H-loop/switch region; other site 507522014028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522014029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522014030 substrate binding pocket [chemical binding]; other site 507522014031 membrane-bound complex binding site; other site 507522014032 hinge residues; other site 507522014033 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 507522014034 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 507522014035 Walker A/P-loop; other site 507522014036 ATP binding site [chemical binding]; other site 507522014037 Q-loop/lid; other site 507522014038 ABC transporter signature motif; other site 507522014039 Walker B; other site 507522014040 D-loop; other site 507522014041 H-loop/switch region; other site 507522014042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014043 dimer interface [polypeptide binding]; other site 507522014044 conserved gate region; other site 507522014045 putative PBP binding loops; other site 507522014046 ABC-ATPase subunit interface; other site 507522014047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014048 dimer interface [polypeptide binding]; other site 507522014049 conserved gate region; other site 507522014050 putative PBP binding loops; other site 507522014051 ABC-ATPase subunit interface; other site 507522014052 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522014053 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522014054 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 507522014055 putative fimbrial protein TcfA; Provisional; Region: PRK15308 507522014056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522014057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522014058 DNA binding residues [nucleotide binding] 507522014059 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 507522014060 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 507522014061 Walker A/P-loop; other site 507522014062 ATP binding site [chemical binding]; other site 507522014063 Q-loop/lid; other site 507522014064 ABC transporter signature motif; other site 507522014065 Walker B; other site 507522014066 D-loop; other site 507522014067 H-loop/switch region; other site 507522014068 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 507522014069 Transferrin; Region: Transferrin; cl02460 507522014070 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 507522014071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014072 dimer interface [polypeptide binding]; other site 507522014073 conserved gate region; other site 507522014074 putative PBP binding loops; other site 507522014075 ABC-ATPase subunit interface; other site 507522014076 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 507522014077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 507522014078 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 507522014079 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 507522014080 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 507522014081 EamA-like transporter family; Region: EamA; pfam00892 507522014082 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 507522014083 NlpC/P60 family; Region: NLPC_P60; pfam00877 507522014084 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 507522014085 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 507522014086 trimer interface [polypeptide binding]; other site 507522014087 eyelet of channel; other site 507522014088 gamma-glutamyl kinase; Provisional; Region: PRK05429 507522014089 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 507522014090 nucleotide binding site [chemical binding]; other site 507522014091 homotetrameric interface [polypeptide binding]; other site 507522014092 putative phosphate binding site [ion binding]; other site 507522014093 putative allosteric binding site; other site 507522014094 PUA domain; Region: PUA; pfam01472 507522014095 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 507522014096 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 507522014097 putative catalytic cysteine [active] 507522014098 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 507522014099 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522014100 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 507522014101 catalytic residues [active] 507522014102 catalytic nucleophile [active] 507522014103 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 507522014104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 507522014105 active site 507522014106 DNA binding site [nucleotide binding] 507522014107 Int/Topo IB signature motif; other site 507522014108 integrase; Provisional; Region: PRK09692 507522014109 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522014110 active site 507522014111 Int/Topo IB signature motif; other site 507522014112 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 507522014113 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 507522014114 Hyccin; Region: Hyccin; pfam09790 507522014115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 507522014116 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 507522014117 active site 507522014118 catalytic residues [active] 507522014119 DNA binding site [nucleotide binding] 507522014120 Int/Topo IB signature motif; other site 507522014121 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 507522014122 active site 507522014123 catalytic residues [active] 507522014124 DNA binding site [nucleotide binding] 507522014125 Int/Topo IB signature motif; other site 507522014126 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 507522014127 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 507522014128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522014129 FeS/SAM binding site; other site 507522014130 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 507522014131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522014132 FeS/SAM binding site; other site 507522014133 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 507522014134 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 507522014135 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522014136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522014137 ParB-like nuclease domain; Region: ParBc; cl02129 507522014138 RepB plasmid partitioning protein; Region: RepB; pfam07506 507522014139 ParB-like nuclease domain; Region: ParB; smart00470 507522014140 Rio2, N-terminal; Region: Rio2_N; pfam09202 507522014141 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 507522014142 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 507522014143 catalytic residues [active] 507522014144 catalytic nucleophile [active] 507522014145 Recombinase; Region: Recombinase; pfam07508 507522014146 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 507522014147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014148 dimer interface [polypeptide binding]; other site 507522014149 conserved gate region; other site 507522014150 putative PBP binding loops; other site 507522014151 ABC-ATPase subunit interface; other site 507522014152 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 507522014153 NMT1-like family; Region: NMT1_2; pfam13379 507522014154 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 507522014155 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 507522014156 Walker A/P-loop; other site 507522014157 ATP binding site [chemical binding]; other site 507522014158 Q-loop/lid; other site 507522014159 ABC transporter signature motif; other site 507522014160 Walker B; other site 507522014161 D-loop; other site 507522014162 H-loop/switch region; other site 507522014163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 507522014164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 507522014165 active site 507522014166 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 507522014167 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 507522014168 Cupin; Region: Cupin_6; pfam12852 507522014169 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522014170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522014171 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522014172 sulfite reductase subunit beta; Provisional; Region: PRK13504 507522014173 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522014174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 507522014175 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 507522014176 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 507522014177 catalytic triad [active] 507522014178 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 507522014179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522014180 DNA binding residues [nucleotide binding] 507522014181 dimerization interface [polypeptide binding]; other site 507522014182 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 507522014183 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 507522014184 tetramer interface [polypeptide binding]; other site 507522014185 TPP-binding site [chemical binding]; other site 507522014186 heterodimer interface [polypeptide binding]; other site 507522014187 phosphorylation loop region [posttranslational modification] 507522014188 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 507522014189 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 507522014190 alpha subunit interface [polypeptide binding]; other site 507522014191 TPP binding site [chemical binding]; other site 507522014192 heterodimer interface [polypeptide binding]; other site 507522014193 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 507522014194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522014195 E3 interaction surface; other site 507522014196 lipoyl attachment site [posttranslational modification]; other site 507522014197 e3 binding domain; Region: E3_binding; pfam02817 507522014198 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 507522014199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 507522014200 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 507522014201 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 507522014202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522014203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 507522014204 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 507522014205 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 507522014206 Class I aldolases; Region: Aldolase_Class_I; cl17187 507522014207 catalytic residue [active] 507522014208 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 507522014209 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 507522014210 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 507522014211 putative N- and C-terminal domain interface [polypeptide binding]; other site 507522014212 putative active site [active] 507522014213 MgATP binding site [chemical binding]; other site 507522014214 catalytic site [active] 507522014215 metal binding site [ion binding]; metal-binding site 507522014216 putative xylulose binding site [chemical binding]; other site 507522014217 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 507522014218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522014219 NAD(P) binding site [chemical binding]; other site 507522014220 active site 507522014221 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 507522014222 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 507522014223 putative ligand binding site [chemical binding]; other site 507522014224 putative NAD binding site [chemical binding]; other site 507522014225 catalytic site [active] 507522014226 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 507522014227 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 507522014228 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522014229 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 507522014230 putative C-terminal domain interface [polypeptide binding]; other site 507522014231 putative GSH binding site (G-site) [chemical binding]; other site 507522014232 putative dimer interface [polypeptide binding]; other site 507522014233 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 507522014234 putative N-terminal domain interface [polypeptide binding]; other site 507522014235 putative dimer interface [polypeptide binding]; other site 507522014236 putative substrate binding pocket (H-site) [chemical binding]; other site 507522014237 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522014238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522014239 S-adenosylmethionine binding site [chemical binding]; other site 507522014240 hypothetical protein; Provisional; Region: PRK13687 507522014241 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 507522014242 substrate binding pocket [chemical binding]; other site 507522014243 active site 507522014244 iron coordination sites [ion binding]; other site 507522014245 Predicted dehydrogenase [General function prediction only]; Region: COG0579 507522014246 hydroxyglutarate oxidase; Provisional; Region: PRK11728 507522014247 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 507522014248 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 507522014249 tetramerization interface [polypeptide binding]; other site 507522014250 NAD(P) binding site [chemical binding]; other site 507522014251 catalytic residues [active] 507522014252 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 507522014253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522014254 inhibitor-cofactor binding pocket; inhibition site 507522014255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522014256 catalytic residue [active] 507522014257 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 507522014258 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 507522014259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522014260 DNA-binding site [nucleotide binding]; DNA binding site 507522014261 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522014262 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 507522014263 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 507522014264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522014265 active site 507522014266 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 507522014267 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 507522014268 metal binding site [ion binding]; metal-binding site 507522014269 dimer interface [polypeptide binding]; other site 507522014270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522014271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522014272 Coenzyme A binding pocket [chemical binding]; other site 507522014273 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 507522014274 active site 507522014275 DNA polymerase IV; Validated; Region: PRK02406 507522014276 DNA binding site [nucleotide binding] 507522014277 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 507522014278 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 507522014279 active site 507522014280 catalytic site [active] 507522014281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 507522014282 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 507522014283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 507522014284 catalytic loop [active] 507522014285 iron binding site [ion binding]; other site 507522014286 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 507522014287 FAD binding pocket [chemical binding]; other site 507522014288 FAD binding motif [chemical binding]; other site 507522014289 phosphate binding motif [ion binding]; other site 507522014290 beta-alpha-beta structure motif; other site 507522014291 NAD binding pocket [chemical binding]; other site 507522014292 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 507522014293 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 507522014294 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 507522014295 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 507522014296 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 507522014297 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 507522014298 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522014299 E3 interaction surface; other site 507522014300 lipoyl attachment site [posttranslational modification]; other site 507522014301 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 507522014302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 507522014303 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 507522014304 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 507522014305 putative active site [active] 507522014306 putative dimer interface [polypeptide binding]; other site 507522014307 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 507522014308 dimer interface [polypeptide binding]; other site 507522014309 active site 507522014310 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 507522014311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 507522014312 active site 507522014313 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 507522014314 C-N hydrolase family amidase; Provisional; Region: PRK10438 507522014315 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 507522014316 putative active site [active] 507522014317 catalytic triad [active] 507522014318 dimer interface [polypeptide binding]; other site 507522014319 multimer interface [polypeptide binding]; other site 507522014320 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 507522014321 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 507522014322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522014323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522014324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 507522014325 dimerization interface [polypeptide binding]; other site 507522014326 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 507522014327 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 507522014328 active site 507522014329 catalytic site [active] 507522014330 substrate binding site [chemical binding]; other site 507522014331 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 507522014332 RNA/DNA hybrid binding site [nucleotide binding]; other site 507522014333 active site 507522014334 Methyltransferase domain; Region: Methyltransf_11; pfam08241 507522014335 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 507522014336 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 507522014337 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522014338 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522014339 catalytic residue [active] 507522014340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522014341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 507522014342 hypothetical protein; Provisional; Region: PRK08317 507522014343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522014344 S-adenosylmethionine binding site [chemical binding]; other site 507522014345 hypothetical protein; Provisional; Region: PRK05421 507522014346 putative catalytic site [active] 507522014347 putative metal binding site [ion binding]; other site 507522014348 putative phosphate binding site [ion binding]; other site 507522014349 putative catalytic site [active] 507522014350 putative phosphate binding site [ion binding]; other site 507522014351 putative metal binding site [ion binding]; other site 507522014352 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 507522014353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522014354 putative substrate translocation pore; other site 507522014355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522014356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522014357 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 507522014358 putative effector binding pocket; other site 507522014359 dimerization interface [polypeptide binding]; other site 507522014360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 507522014361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 507522014362 active site 507522014363 catalytic tetrad [active] 507522014364 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 507522014365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522014366 active site 507522014367 motif I; other site 507522014368 motif II; other site 507522014369 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 507522014370 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 507522014371 Walker A/P-loop; other site 507522014372 ATP binding site [chemical binding]; other site 507522014373 Q-loop/lid; other site 507522014374 ABC transporter signature motif; other site 507522014375 Walker B; other site 507522014376 D-loop; other site 507522014377 H-loop/switch region; other site 507522014378 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 507522014379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014380 dimer interface [polypeptide binding]; other site 507522014381 conserved gate region; other site 507522014382 ABC-ATPase subunit interface; other site 507522014383 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 507522014384 lipoprotein, YaeC family; Region: TIGR00363 507522014385 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 507522014386 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 507522014387 homodimer interaction site [polypeptide binding]; other site 507522014388 cofactor binding site; other site 507522014389 prolyl-tRNA synthetase; Provisional; Region: PRK09194 507522014390 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 507522014391 dimer interface [polypeptide binding]; other site 507522014392 motif 1; other site 507522014393 active site 507522014394 motif 2; other site 507522014395 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 507522014396 putative deacylase active site [active] 507522014397 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 507522014398 active site 507522014399 motif 3; other site 507522014400 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 507522014401 anticodon binding site; other site 507522014402 hypothetical protein; Provisional; Region: PRK11479 507522014403 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 507522014404 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 507522014405 NlpE N-terminal domain; Region: NlpE; pfam04170 507522014406 hypothetical protein; Provisional; Region: PRK09256 507522014407 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 507522014408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 507522014409 Rho-binding antiterminator; Provisional; Region: PRK11625 507522014410 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 507522014411 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 507522014412 Ligand Binding Site [chemical binding]; other site 507522014413 TilS substrate binding domain; Region: TilS; pfam09179 507522014414 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 507522014415 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 507522014416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522014417 putative metal binding site [ion binding]; other site 507522014418 lysine decarboxylase LdcC; Provisional; Region: PRK15399 507522014419 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 507522014420 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 507522014421 homodimer interface [polypeptide binding]; other site 507522014422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522014423 catalytic residue [active] 507522014424 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 507522014425 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 507522014426 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 507522014427 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 507522014428 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 507522014429 putative active site [active] 507522014430 putative PHP Thumb interface [polypeptide binding]; other site 507522014431 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 507522014432 generic binding surface II; other site 507522014433 generic binding surface I; other site 507522014434 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 507522014435 RNA/DNA hybrid binding site [nucleotide binding]; other site 507522014436 active site 507522014437 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 507522014438 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 507522014439 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 507522014440 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 507522014441 active site 507522014442 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 507522014443 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 507522014444 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 507522014445 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 507522014446 trimer interface [polypeptide binding]; other site 507522014447 active site 507522014448 UDP-GlcNAc binding site [chemical binding]; other site 507522014449 lipid binding site [chemical binding]; lipid-binding site 507522014450 periplasmic chaperone; Provisional; Region: PRK10780 507522014451 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 507522014452 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 507522014453 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522014454 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522014455 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522014456 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522014457 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522014458 Surface antigen; Region: Bac_surface_Ag; pfam01103 507522014459 zinc metallopeptidase RseP; Provisional; Region: PRK10779 507522014460 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 507522014461 active site 507522014462 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 507522014463 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 507522014464 protein binding site [polypeptide binding]; other site 507522014465 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 507522014466 putative substrate binding region [chemical binding]; other site 507522014467 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 507522014468 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 507522014469 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 507522014470 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 507522014471 catalytic residue [active] 507522014472 putative FPP diphosphate binding site; other site 507522014473 putative FPP binding hydrophobic cleft; other site 507522014474 dimer interface [polypeptide binding]; other site 507522014475 putative IPP diphosphate binding site; other site 507522014476 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 507522014477 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 507522014478 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 507522014479 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 507522014480 ribosome recycling factor; Reviewed; Region: frr; PRK00083 507522014481 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 507522014482 hinge region; other site 507522014483 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 507522014484 putative nucleotide binding site [chemical binding]; other site 507522014485 uridine monophosphate binding site [chemical binding]; other site 507522014486 homohexameric interface [polypeptide binding]; other site 507522014487 elongation factor Ts; Provisional; Region: tsf; PRK09377 507522014488 UBA/TS-N domain; Region: UBA; pfam00627 507522014489 Elongation factor TS; Region: EF_TS; pfam00889 507522014490 Elongation factor TS; Region: EF_TS; pfam00889 507522014491 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 507522014492 rRNA interaction site [nucleotide binding]; other site 507522014493 S8 interaction site; other site 507522014494 putative laminin-1 binding site; other site 507522014495 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 507522014496 active site 507522014497 PII uridylyl-transferase; Provisional; Region: PRK05007 507522014498 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 507522014499 metal binding triad; other site 507522014500 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 507522014501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522014502 Zn2+ binding site [ion binding]; other site 507522014503 Mg2+ binding site [ion binding]; other site 507522014504 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 507522014505 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 507522014506 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 507522014507 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 507522014508 trimer interface [polypeptide binding]; other site 507522014509 active site 507522014510 substrate binding site [chemical binding]; other site 507522014511 CoA binding site [chemical binding]; other site 507522014512 hypothetical protein; Provisional; Region: PRK13677 507522014513 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 507522014514 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 507522014515 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 507522014516 serine endoprotease; Provisional; Region: PRK10942 507522014517 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 507522014518 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 507522014519 protein binding site [polypeptide binding]; other site 507522014520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 507522014521 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 507522014522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 507522014523 Zn2+ binding site [ion binding]; other site 507522014524 Mg2+ binding site [ion binding]; other site 507522014525 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 507522014526 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 507522014527 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 507522014528 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 507522014529 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 507522014530 cobalamin binding residues [chemical binding]; other site 507522014531 putative BtuC binding residues; other site 507522014532 dimer interface [polypeptide binding]; other site 507522014533 hypothetical protein; Provisional; Region: PRK10578 507522014534 UPF0126 domain; Region: UPF0126; pfam03458 507522014535 UPF0126 domain; Region: UPF0126; pfam03458 507522014536 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 507522014537 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 507522014538 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 507522014539 Cl- selectivity filter; other site 507522014540 Cl- binding residues [ion binding]; other site 507522014541 pore gating glutamate residue; other site 507522014542 dimer interface [polypeptide binding]; other site 507522014543 H+/Cl- coupling transport residue; other site 507522014544 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 507522014545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 507522014546 inhibitor-cofactor binding pocket; inhibition site 507522014547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522014548 catalytic residue [active] 507522014549 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 507522014550 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522014551 ABC-ATPase subunit interface; other site 507522014552 dimer interface [polypeptide binding]; other site 507522014553 putative PBP binding regions; other site 507522014554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 507522014555 ABC-ATPase subunit interface; other site 507522014556 dimer interface [polypeptide binding]; other site 507522014557 putative PBP binding regions; other site 507522014558 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 507522014559 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 507522014560 Walker A/P-loop; other site 507522014561 ATP binding site [chemical binding]; other site 507522014562 Q-loop/lid; other site 507522014563 ABC transporter signature motif; other site 507522014564 Walker B; other site 507522014565 D-loop; other site 507522014566 H-loop/switch region; other site 507522014567 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 507522014568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522014569 N-terminal plug; other site 507522014570 ligand-binding site [chemical binding]; other site 507522014571 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 507522014572 Transglycosylase; Region: Transgly; pfam00912 507522014573 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 507522014574 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 507522014575 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 507522014576 carbohydrate binding site [chemical binding]; other site 507522014577 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 507522014578 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 507522014579 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 507522014580 Ca binding site [ion binding]; other site 507522014581 active site 507522014582 catalytic site [active] 507522014583 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 507522014584 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 507522014585 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 507522014586 type II secretion system protein D; Region: type_II_gspD; TIGR02517 507522014587 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 507522014588 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 507522014589 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 507522014590 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 507522014591 type II secretion system protein E; Region: type_II_gspE; TIGR02533 507522014592 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 507522014593 Walker A motif; other site 507522014594 ATP binding site [chemical binding]; other site 507522014595 Walker B motif; other site 507522014596 type II secretion system protein F; Region: GspF; TIGR02120 507522014597 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 507522014598 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 507522014599 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 507522014600 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 507522014601 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 507522014602 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 507522014603 type II secretion system protein I; Region: gspI; TIGR01707 507522014604 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 507522014605 type II secretion system protein J; Region: gspJ; TIGR01711 507522014606 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 507522014607 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 507522014608 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 507522014609 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 507522014610 GspL periplasmic domain; Region: GspL_C; pfam12693 507522014611 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 507522014612 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 507522014613 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 507522014614 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 507522014615 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 507522014616 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 507522014617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522014618 ATP binding site [chemical binding]; other site 507522014619 putative Mg++ binding site [ion binding]; other site 507522014620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522014621 nucleotide binding region [chemical binding]; other site 507522014622 ATP-binding site [chemical binding]; other site 507522014623 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 507522014624 2'-5' RNA ligase; Provisional; Region: PRK15124 507522014625 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 507522014626 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 507522014627 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 507522014628 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 507522014629 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 507522014630 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 507522014631 active site 507522014632 nucleotide binding site [chemical binding]; other site 507522014633 HIGH motif; other site 507522014634 KMSKS motif; other site 507522014635 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 507522014636 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 507522014637 active site 507522014638 NTP binding site [chemical binding]; other site 507522014639 metal binding triad [ion binding]; metal-binding site 507522014640 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 507522014641 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 507522014642 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 507522014643 catalytic center binding site [active] 507522014644 ATP binding site [chemical binding]; other site 507522014645 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 507522014646 oligomerization interface [polypeptide binding]; other site 507522014647 active site 507522014648 metal binding site [ion binding]; metal-binding site 507522014649 pantoate--beta-alanine ligase; Region: panC; TIGR00018 507522014650 Pantoate-beta-alanine ligase; Region: PanC; cd00560 507522014651 active site 507522014652 ATP-binding site [chemical binding]; other site 507522014653 pantoate-binding site; other site 507522014654 HXXH motif; other site 507522014655 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 507522014656 tetramerization interface [polypeptide binding]; other site 507522014657 active site 507522014658 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 507522014659 putative active site [active] 507522014660 putative metal binding site [ion binding]; other site 507522014661 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 507522014662 active pocket/dimerization site; other site 507522014663 active site 507522014664 phosphorylation site [posttranslational modification] 507522014665 inner membrane transport permease; Provisional; Region: PRK15066 507522014666 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522014667 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 507522014668 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522014669 Walker A/P-loop; other site 507522014670 ATP binding site [chemical binding]; other site 507522014671 Q-loop/lid; other site 507522014672 ABC transporter signature motif; other site 507522014673 Walker B; other site 507522014674 D-loop; other site 507522014675 H-loop/switch region; other site 507522014676 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 507522014677 active site clefts [active] 507522014678 zinc binding site [ion binding]; other site 507522014679 dimer interface [polypeptide binding]; other site 507522014680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 507522014681 active site 507522014682 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 507522014683 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 507522014684 Trp docking motif [polypeptide binding]; other site 507522014685 putative active site [active] 507522014686 multicopper oxidase; Provisional; Region: PRK10965 507522014687 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 507522014688 Multicopper oxidase; Region: Cu-oxidase; pfam00394 507522014689 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 507522014690 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 507522014691 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 507522014692 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 507522014693 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522014694 spermidine synthase; Provisional; Region: PRK00811 507522014695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522014696 S-adenosylmethionine binding site [chemical binding]; other site 507522014697 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 507522014698 hypothetical protein; Provisional; Region: PRK05248 507522014699 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 507522014700 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 507522014701 substrate binding site [chemical binding]; other site 507522014702 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 507522014703 substrate binding site [chemical binding]; other site 507522014704 ligand binding site [chemical binding]; other site 507522014705 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 507522014706 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 507522014707 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 507522014708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 507522014709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522014710 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 507522014711 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 507522014712 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522014713 E3 interaction surface; other site 507522014714 lipoyl attachment site [posttranslational modification]; other site 507522014715 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522014716 E3 interaction surface; other site 507522014717 lipoyl attachment site [posttranslational modification]; other site 507522014718 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 507522014719 E3 interaction surface; other site 507522014720 lipoyl attachment site [posttranslational modification]; other site 507522014721 e3 binding domain; Region: E3_binding; pfam02817 507522014722 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 507522014723 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 507522014724 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 507522014725 dimer interface [polypeptide binding]; other site 507522014726 TPP-binding site [chemical binding]; other site 507522014727 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 507522014728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522014729 DNA-binding site [nucleotide binding]; DNA binding site 507522014730 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522014731 aromatic amino acid transporter; Provisional; Region: PRK10238 507522014732 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522014733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522014734 putative substrate translocation pore; other site 507522014735 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 507522014736 active site 507522014737 regulatory protein AmpE; Provisional; Region: PRK10987 507522014738 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 507522014739 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 507522014740 amidase catalytic site [active] 507522014741 Zn binding residues [ion binding]; other site 507522014742 substrate binding site [chemical binding]; other site 507522014743 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 507522014744 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 507522014745 dimerization interface [polypeptide binding]; other site 507522014746 active site 507522014747 putative major pilin subunit; Provisional; Region: PRK10574 507522014748 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 507522014749 Pilin (bacterial filament); Region: Pilin; pfam00114 507522014750 hypothetical protein; Provisional; Region: PRK10436 507522014751 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 507522014752 Walker A motif; other site 507522014753 ATP binding site [chemical binding]; other site 507522014754 Walker B motif; other site 507522014755 type IV pilin biogenesis protein; Provisional; Region: PRK10573 507522014756 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 507522014757 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 507522014758 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 507522014759 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 507522014760 active site 507522014761 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 507522014762 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 507522014763 CoA-binding site [chemical binding]; other site 507522014764 ATP-binding [chemical binding]; other site 507522014765 hypothetical protein; Provisional; Region: PRK05287 507522014766 DNA gyrase inhibitor; Reviewed; Region: PRK00418 507522014767 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 507522014768 active site 507522014769 8-oxo-dGMP binding site [chemical binding]; other site 507522014770 nudix motif; other site 507522014771 metal binding site [ion binding]; metal-binding site 507522014772 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 507522014773 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 507522014774 SEC-C motif; Region: SEC-C; pfam02810 507522014775 SecA regulator SecM; Provisional; Region: PRK02943 507522014776 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 507522014777 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 507522014778 cell division protein FtsZ; Validated; Region: PRK09330 507522014779 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 507522014780 nucleotide binding site [chemical binding]; other site 507522014781 SulA interaction site; other site 507522014782 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 507522014783 Cell division protein FtsA; Region: FtsA; pfam14450 507522014784 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 507522014785 Cell division protein FtsA; Region: FtsA; pfam14450 507522014786 cell division protein FtsQ; Provisional; Region: PRK10775 507522014787 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 507522014788 Cell division protein FtsQ; Region: FtsQ; pfam03799 507522014789 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 507522014790 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 507522014791 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 507522014792 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 507522014793 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 507522014794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522014795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522014796 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 507522014797 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 507522014798 active site 507522014799 homodimer interface [polypeptide binding]; other site 507522014800 cell division protein FtsW; Provisional; Region: PRK10774 507522014801 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 507522014802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522014803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522014804 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 507522014805 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 507522014806 Mg++ binding site [ion binding]; other site 507522014807 putative catalytic motif [active] 507522014808 putative substrate binding site [chemical binding]; other site 507522014809 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 507522014810 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 507522014811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522014812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522014813 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 507522014814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522014815 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522014816 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 507522014817 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 507522014818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 507522014819 cell division protein FtsL; Provisional; Region: PRK10772 507522014820 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 507522014821 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 507522014822 mraZ protein; Region: TIGR00242 507522014823 MraZ protein; Region: MraZ; pfam02381 507522014824 MraZ protein; Region: MraZ; pfam02381 507522014825 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 507522014826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522014827 DNA binding site [nucleotide binding] 507522014828 domain linker motif; other site 507522014829 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 507522014830 dimerization interface [polypeptide binding]; other site 507522014831 ligand binding site [chemical binding]; other site 507522014832 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 507522014833 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 507522014834 putative valine binding site [chemical binding]; other site 507522014835 dimer interface [polypeptide binding]; other site 507522014836 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 507522014837 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 507522014838 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522014839 PYR/PP interface [polypeptide binding]; other site 507522014840 dimer interface [polypeptide binding]; other site 507522014841 TPP binding site [chemical binding]; other site 507522014842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522014843 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 507522014844 TPP-binding site [chemical binding]; other site 507522014845 dimer interface [polypeptide binding]; other site 507522014846 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 507522014847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522014848 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 507522014849 putative substrate binding pocket [chemical binding]; other site 507522014850 putative dimerization interface [polypeptide binding]; other site 507522014851 2-isopropylmalate synthase; Validated; Region: PRK00915 507522014852 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 507522014853 active site 507522014854 catalytic residues [active] 507522014855 metal binding site [ion binding]; metal-binding site 507522014856 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 507522014857 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 507522014858 tartrate dehydrogenase; Region: TTC; TIGR02089 507522014859 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 507522014860 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 507522014861 substrate binding site [chemical binding]; other site 507522014862 ligand binding site [chemical binding]; other site 507522014863 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 507522014864 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 507522014865 substrate binding site [chemical binding]; other site 507522014866 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 507522014867 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 507522014868 active site 507522014869 FMN binding site [chemical binding]; other site 507522014870 substrate binding site [chemical binding]; other site 507522014871 putative catalytic residue [active] 507522014872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 507522014873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522014874 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 507522014875 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 507522014876 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 507522014877 shikimate binding site; other site 507522014878 NAD(P) binding site [chemical binding]; other site 507522014879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522014880 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 507522014881 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 507522014882 active site 507522014883 catalytic residue [active] 507522014884 dimer interface [polypeptide binding]; other site 507522014885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522014886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522014887 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 507522014888 putative dimerization interface [polypeptide binding]; other site 507522014889 D-galactonate transporter; Region: 2A0114; TIGR00893 507522014890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522014891 putative substrate translocation pore; other site 507522014892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522014893 sugar efflux transporter; Region: 2A0120; TIGR00899 507522014894 putative substrate translocation pore; other site 507522014895 transcriptional regulator SgrR; Provisional; Region: PRK13626 507522014896 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 507522014897 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 507522014898 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 507522014899 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 507522014900 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 507522014901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014902 dimer interface [polypeptide binding]; other site 507522014903 conserved gate region; other site 507522014904 putative PBP binding loops; other site 507522014905 ABC-ATPase subunit interface; other site 507522014906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522014907 dimer interface [polypeptide binding]; other site 507522014908 conserved gate region; other site 507522014909 putative PBP binding loops; other site 507522014910 ABC-ATPase subunit interface; other site 507522014911 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 507522014912 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 507522014913 Walker A/P-loop; other site 507522014914 ATP binding site [chemical binding]; other site 507522014915 Q-loop/lid; other site 507522014916 ABC transporter signature motif; other site 507522014917 Walker B; other site 507522014918 D-loop; other site 507522014919 H-loop/switch region; other site 507522014920 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 507522014921 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 507522014922 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 507522014923 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522014924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522014925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522014926 ribulokinase; Provisional; Region: PRK04123 507522014927 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 507522014928 N- and C-terminal domain interface [polypeptide binding]; other site 507522014929 active site 507522014930 MgATP binding site [chemical binding]; other site 507522014931 catalytic site [active] 507522014932 metal binding site [ion binding]; metal-binding site 507522014933 carbohydrate binding site [chemical binding]; other site 507522014934 homodimer interface [polypeptide binding]; other site 507522014935 L-arabinose isomerase; Provisional; Region: PRK02929 507522014936 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 507522014937 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 507522014938 trimer interface [polypeptide binding]; other site 507522014939 putative substrate binding site [chemical binding]; other site 507522014940 putative metal binding site [ion binding]; other site 507522014941 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 507522014942 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 507522014943 intersubunit interface [polypeptide binding]; other site 507522014944 active site 507522014945 Zn2+ binding site [ion binding]; other site 507522014946 DNA polymerase II; Reviewed; Region: PRK05762 507522014947 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 507522014948 active site 507522014949 catalytic site [active] 507522014950 substrate binding site [chemical binding]; other site 507522014951 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 507522014952 active site 507522014953 metal-binding site 507522014954 ATP-dependent helicase HepA; Validated; Region: PRK04914 507522014955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522014956 ATP binding site [chemical binding]; other site 507522014957 putative Mg++ binding site [ion binding]; other site 507522014958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522014959 nucleotide binding region [chemical binding]; other site 507522014960 ATP-binding site [chemical binding]; other site 507522014961 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 507522014962 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 507522014963 active site 507522014964 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 507522014965 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 507522014966 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 507522014967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 507522014968 putative active site [active] 507522014969 heme pocket [chemical binding]; other site 507522014970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522014971 ATP binding site [chemical binding]; other site 507522014972 Mg2+ binding site [ion binding]; other site 507522014973 G-X-G motif; other site 507522014974 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 507522014975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522014976 active site 507522014977 phosphorylation site [posttranslational modification] 507522014978 intermolecular recognition site; other site 507522014979 dimerization interface [polypeptide binding]; other site 507522014980 Transcriptional regulator; Region: CitT; pfam12431 507522014981 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 507522014982 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 507522014983 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 507522014984 putative metal binding site [ion binding]; other site 507522014985 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 507522014986 HSP70 interaction site [polypeptide binding]; other site 507522014987 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 507522014988 OstA-like protein; Region: OstA; pfam03968 507522014989 Organic solvent tolerance protein; Region: OstA_C; pfam04453 507522014990 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 507522014991 SurA N-terminal domain; Region: SurA_N; pfam09312 507522014992 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 507522014993 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 507522014994 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 507522014995 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 507522014996 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 507522014997 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 507522014998 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 507522014999 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 507522015000 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 507522015001 active site 507522015002 metal binding site [ion binding]; metal-binding site 507522015003 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 507522015004 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 507522015005 folate binding site [chemical binding]; other site 507522015006 NADP+ binding site [chemical binding]; other site 507522015007 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 507522015008 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 507522015009 TrkA-N domain; Region: TrkA_N; pfam02254 507522015010 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 507522015011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015012 D-galactonate transporter; Region: 2A0114; TIGR00893 507522015013 putative substrate translocation pore; other site 507522015014 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 507522015015 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 507522015016 putative ligand binding site [chemical binding]; other site 507522015017 NAD binding site [chemical binding]; other site 507522015018 catalytic site [active] 507522015019 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 507522015020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522015021 DNA binding site [nucleotide binding] 507522015022 domain linker motif; other site 507522015023 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 507522015024 putative ligand binding site [chemical binding]; other site 507522015025 putative dimerization interface [polypeptide binding]; other site 507522015026 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 507522015027 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 507522015028 NADP binding site [chemical binding]; other site 507522015029 homodimer interface [polypeptide binding]; other site 507522015030 active site 507522015031 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 507522015032 AAA domain; Region: AAA_33; pfam13671 507522015033 ATP-binding site [chemical binding]; other site 507522015034 Gluconate-6-phosphate binding site [chemical binding]; other site 507522015035 Domain of unknown function (DUF386); Region: DUF386; cl01047 507522015036 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 507522015037 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 507522015038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 507522015039 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 507522015040 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 507522015041 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 507522015042 ATP-grasp domain; Region: ATP-grasp_4; cl17255 507522015043 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 507522015044 IMP binding site; other site 507522015045 dimer interface [polypeptide binding]; other site 507522015046 interdomain contacts; other site 507522015047 partial ornithine binding site; other site 507522015048 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 507522015049 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 507522015050 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 507522015051 catalytic site [active] 507522015052 subunit interface [polypeptide binding]; other site 507522015053 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 507522015054 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 507522015055 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 507522015056 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 507522015057 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 507522015058 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 507522015059 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 507522015060 citrate lyase subunit gamma; Provisional; Region: PRK13253 507522015061 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 507522015062 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 507522015063 putative active site [active] 507522015064 (T/H)XGH motif; other site 507522015065 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 507522015066 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 507522015067 oxaloacetate decarboxylase; Provisional; Region: PRK14040 507522015068 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 507522015069 active site 507522015070 catalytic residues [active] 507522015071 metal binding site [ion binding]; metal-binding site 507522015072 homodimer binding site [polypeptide binding]; other site 507522015073 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 507522015074 carboxyltransferase (CT) interaction site; other site 507522015075 biotinylation site [posttranslational modification]; other site 507522015076 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 507522015077 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 507522015078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 507522015079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522015080 ATP binding site [chemical binding]; other site 507522015081 Mg2+ binding site [ion binding]; other site 507522015082 G-X-G motif; other site 507522015083 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 507522015084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522015085 active site 507522015086 phosphorylation site [posttranslational modification] 507522015087 intermolecular recognition site; other site 507522015088 dimerization interface [polypeptide binding]; other site 507522015089 Transcriptional regulator; Region: CitT; pfam12431 507522015090 alanine-tRNA ligase; Region: PLN02961 507522015091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 507522015092 transcriptional regulator, ArgP family; Region: argP; TIGR03298 507522015093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522015094 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522015095 putative effector binding pocket; other site 507522015096 dimerization interface [polypeptide binding]; other site 507522015097 Protein of unknown function (DUF805); Region: DUF805; pfam05656 507522015098 putative hydratase; Provisional; Region: PRK11413 507522015099 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 507522015100 substrate binding site [chemical binding]; other site 507522015101 ligand binding site [chemical binding]; other site 507522015102 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 507522015103 substrate binding site [chemical binding]; other site 507522015104 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 507522015105 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 507522015106 transmembrane helices; other site 507522015107 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 507522015108 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 507522015109 transmembrane helices; other site 507522015110 PrpF protein; Region: PrpF; pfam04303 507522015111 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 507522015112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522015113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522015114 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 507522015115 putative dimerization interface [polypeptide binding]; other site 507522015116 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 507522015117 active site 507522015118 tetramer interface [polypeptide binding]; other site 507522015119 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 507522015120 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 507522015121 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 507522015122 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522015123 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 507522015124 lipoprotein signal peptidase; Provisional; Region: PRK14787 507522015125 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 507522015126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 507522015127 active site 507522015128 HIGH motif; other site 507522015129 nucleotide binding site [chemical binding]; other site 507522015130 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 507522015131 active site 507522015132 KMSKS motif; other site 507522015133 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 507522015134 tRNA binding surface [nucleotide binding]; other site 507522015135 anticodon binding site; other site 507522015136 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 507522015137 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 507522015138 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 507522015139 active site 507522015140 Riboflavin kinase; Region: Flavokinase; smart00904 507522015141 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 507522015142 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 507522015143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522015144 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 507522015145 putative dimerization interface [polypeptide binding]; other site 507522015146 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 507522015147 chaperone protein DnaJ; Provisional; Region: PRK10767 507522015148 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 507522015149 HSP70 interaction site [polypeptide binding]; other site 507522015150 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 507522015151 substrate binding site [polypeptide binding]; other site 507522015152 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 507522015153 Zn binding sites [ion binding]; other site 507522015154 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 507522015155 dimer interface [polypeptide binding]; other site 507522015156 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 507522015157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 507522015158 nucleotide binding site [chemical binding]; other site 507522015159 hypothetical protein; Provisional; Region: PRK10154 507522015160 hypothetical protein; Provisional; Region: PRK10236 507522015161 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 507522015162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 507522015163 hypothetical protein; Provisional; Region: PRK10659 507522015164 metabolite-proton symporter; Region: 2A0106; TIGR00883 507522015165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015166 putative substrate translocation pore; other site 507522015167 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 507522015168 MPT binding site; other site 507522015169 trimer interface [polypeptide binding]; other site 507522015170 transaldolase-like protein; Provisional; Region: PTZ00411 507522015171 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 507522015172 active site 507522015173 dimer interface [polypeptide binding]; other site 507522015174 catalytic residue [active] 507522015175 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 507522015176 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 507522015177 hypothetical protein; Validated; Region: PRK02101 507522015178 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 507522015179 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 507522015180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522015181 catalytic residue [active] 507522015182 homoserine kinase; Provisional; Region: PRK01212 507522015183 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 507522015184 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 507522015185 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 507522015186 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 507522015187 putative catalytic residues [active] 507522015188 putative nucleotide binding site [chemical binding]; other site 507522015189 putative aspartate binding site [chemical binding]; other site 507522015190 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 507522015191 dimer interface [polypeptide binding]; other site 507522015192 putative threonine allosteric regulatory site; other site 507522015193 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 507522015194 putative threonine allosteric regulatory site; other site 507522015195 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 507522015196 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 507522015197 putative RNA methyltransferase; Provisional; Region: PRK10433 507522015198 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 507522015199 two-component response regulator; Provisional; Region: PRK11173 507522015200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522015201 active site 507522015202 phosphorylation site [posttranslational modification] 507522015203 intermolecular recognition site; other site 507522015204 dimerization interface [polypeptide binding]; other site 507522015205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522015206 DNA binding site [nucleotide binding] 507522015207 Inner membrane protein CreD; Region: CreD; pfam06123 507522015208 sensory histidine kinase CreC; Provisional; Region: PRK11100 507522015209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522015210 dimer interface [polypeptide binding]; other site 507522015211 phosphorylation site [posttranslational modification] 507522015212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522015213 ATP binding site [chemical binding]; other site 507522015214 Mg2+ binding site [ion binding]; other site 507522015215 G-X-G motif; other site 507522015216 DNA-binding response regulator CreB; Provisional; Region: PRK11083 507522015217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522015218 active site 507522015219 phosphorylation site [posttranslational modification] 507522015220 intermolecular recognition site; other site 507522015221 dimerization interface [polypeptide binding]; other site 507522015222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522015223 DNA binding site [nucleotide binding] 507522015224 hypothetical protein; Provisional; Region: PRK10756 507522015225 CreA protein; Region: CreA; pfam05981 507522015226 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 507522015227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015228 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 507522015229 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 507522015230 catalytic core [active] 507522015231 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 507522015232 Trp operon repressor; Provisional; Region: PRK01381 507522015233 lytic murein transglycosylase; Provisional; Region: PRK11619 507522015234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522015235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522015236 catalytic residue [active] 507522015237 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 507522015238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522015239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522015240 ABC transporter; Region: ABC_tran_2; pfam12848 507522015241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 507522015242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522015243 non-specific DNA binding site [nucleotide binding]; other site 507522015244 salt bridge; other site 507522015245 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 507522015246 sequence-specific DNA binding site [nucleotide binding]; other site 507522015247 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 507522015248 active site 507522015249 (T/H)XGH motif; other site 507522015250 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 507522015251 DNA repair protein RadA; Region: sms; TIGR00416 507522015252 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 507522015253 Walker A motif/ATP binding site; other site 507522015254 ATP binding site [chemical binding]; other site 507522015255 Walker B motif; other site 507522015256 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 507522015257 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 507522015258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522015259 active site 507522015260 motif I; other site 507522015261 motif II; other site 507522015262 hypothetical protein; Provisional; Region: PRK11246 507522015263 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 507522015264 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 507522015265 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 507522015266 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 507522015267 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 507522015268 phosphopentomutase; Provisional; Region: PRK05362 507522015269 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 507522015270 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 507522015271 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 507522015272 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 507522015273 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 507522015274 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 507522015275 intersubunit interface [polypeptide binding]; other site 507522015276 active site 507522015277 catalytic residue [active] 507522015278 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 507522015279 active site 507522015280 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 507522015281 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 507522015282 active site 507522015283 nucleophile elbow; other site 507522015284 periplasmic protein; Provisional; Region: PRK10568 507522015285 BON domain; Region: BON; pfam04972 507522015286 BON domain; Region: BON; pfam04972 507522015287 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 507522015288 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 507522015289 G1 box; other site 507522015290 putative GEF interaction site [polypeptide binding]; other site 507522015291 GTP/Mg2+ binding site [chemical binding]; other site 507522015292 Switch I region; other site 507522015293 G2 box; other site 507522015294 G3 box; other site 507522015295 Switch II region; other site 507522015296 G4 box; other site 507522015297 G5 box; other site 507522015298 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 507522015299 dUMP phosphatase; Provisional; Region: PRK09449 507522015300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522015301 motif II; other site 507522015302 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 507522015303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522015304 Coenzyme A binding pocket [chemical binding]; other site 507522015305 DNA polymerase III subunit psi; Validated; Region: PRK06856 507522015306 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 507522015307 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 507522015308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522015309 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 507522015310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522015311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522015312 metal binding site [ion binding]; metal-binding site 507522015313 active site 507522015314 I-site; other site 507522015315 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 507522015316 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 507522015317 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 507522015318 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 507522015319 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 507522015320 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 507522015321 putative deacylase active site [active] 507522015322 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 507522015323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522015324 DNA binding residues [nucleotide binding] 507522015325 dimerization interface [polypeptide binding]; other site 507522015326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 507522015327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 507522015328 DNA binding residues [nucleotide binding] 507522015329 dimerization interface [polypeptide binding]; other site 507522015330 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 507522015331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015332 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 507522015333 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 507522015334 Uncharacterized conserved protein [Function unknown]; Region: COG2966 507522015335 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 507522015336 hypothetical protein; Provisional; Region: PRK09917 507522015337 primosomal protein DnaI; Provisional; Region: PRK02854 507522015338 DNA replication protein DnaC; Validated; Region: PRK07952 507522015339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522015340 Walker A motif; other site 507522015341 ATP binding site [chemical binding]; other site 507522015342 Walker B motif; other site 507522015343 hypothetical protein; Provisional; Region: PRK11667 507522015344 phosphoglycerol transferase I; Provisional; Region: PRK03776 507522015345 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 507522015346 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 507522015347 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 507522015348 dimer interface [polypeptide binding]; other site 507522015349 active site 507522015350 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 507522015351 dimer interface [polypeptide binding]; other site 507522015352 active site 507522015353 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 507522015354 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 507522015355 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 507522015356 active site 507522015357 phosphorylation site [posttranslational modification] 507522015358 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 507522015359 active pocket/dimerization site; other site 507522015360 active site 507522015361 phosphorylation site [posttranslational modification] 507522015362 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 507522015363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522015364 Walker A motif; other site 507522015365 ATP binding site [chemical binding]; other site 507522015366 Walker B motif; other site 507522015367 arginine finger; other site 507522015368 Transcriptional antiterminator [Transcription]; Region: COG3933 507522015369 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 507522015370 active pocket/dimerization site; other site 507522015371 active site 507522015372 phosphorylation site [posttranslational modification] 507522015373 PRD domain; Region: PRD; pfam00874 507522015374 altronate oxidoreductase; Provisional; Region: PRK03643 507522015375 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 507522015376 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 507522015377 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 507522015378 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 507522015379 putative NAD(P) binding site [chemical binding]; other site 507522015380 catalytic Zn binding site [ion binding]; other site 507522015381 structural Zn binding site [ion binding]; other site 507522015382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522015383 DNA-binding site [nucleotide binding]; DNA binding site 507522015384 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522015385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 507522015386 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522015387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015388 D-galactonate transporter; Region: 2A0114; TIGR00893 507522015389 putative substrate translocation pore; other site 507522015390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522015391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522015392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522015393 Coenzyme A binding pocket [chemical binding]; other site 507522015394 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 507522015395 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 507522015396 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 507522015397 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 507522015398 dimer interface [polypeptide binding]; other site 507522015399 NADP binding site [chemical binding]; other site 507522015400 catalytic residues [active] 507522015401 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 507522015402 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 507522015403 inhibitor site; inhibition site 507522015404 active site 507522015405 dimer interface [polypeptide binding]; other site 507522015406 catalytic residue [active] 507522015407 PAS fold; Region: PAS_4; pfam08448 507522015408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522015409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015410 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 507522015411 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 507522015412 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 507522015413 hydroxyglutarate oxidase; Provisional; Region: PRK11728 507522015414 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 507522015415 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 507522015416 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 507522015417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 507522015418 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 507522015419 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 507522015420 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 507522015421 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 507522015422 NAD binding site [chemical binding]; other site 507522015423 catalytic residues [active] 507522015424 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 507522015425 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 507522015426 putative active site [active] 507522015427 putative metal binding site [ion binding]; other site 507522015428 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 507522015429 putative substrate binding pocket [chemical binding]; other site 507522015430 trimer interface [polypeptide binding]; other site 507522015431 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 507522015432 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 507522015433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015434 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 507522015435 putative substrate translocation pore; other site 507522015436 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 507522015437 Cupin domain; Region: Cupin_2; pfam07883 507522015438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015439 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 507522015440 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522015441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522015442 carbon starvation protein A; Provisional; Region: PRK15015 507522015443 Carbon starvation protein CstA; Region: CstA; pfam02554 507522015444 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 507522015445 Uncharacterized small protein [Function unknown]; Region: COG2879 507522015446 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 507522015447 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 507522015448 P-loop, Walker A motif; other site 507522015449 Base recognition motif; other site 507522015450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 507522015451 YfaZ precursor; Region: YfaZ; pfam07437 507522015452 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 507522015453 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 507522015454 NAD(P) binding site [chemical binding]; other site 507522015455 catalytic residues [active] 507522015456 putative transposase; Provisional; Region: PRK09857 507522015457 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 507522015458 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522015459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522015460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015461 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 507522015462 Predicted membrane protein [Function unknown]; Region: COG2733 507522015463 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 507522015464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015465 putative substrate translocation pore; other site 507522015466 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 507522015467 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 507522015468 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 507522015469 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 507522015470 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 507522015471 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 507522015472 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 507522015473 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 507522015474 metal binding site [ion binding]; metal-binding site 507522015475 putative dimer interface [polypeptide binding]; other site 507522015476 hypothetical protein; Provisional; Region: PRK10519 507522015477 Nucleoside recognition; Region: Gate; pfam07670 507522015478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522015479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522015480 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 507522015481 putative dimerization interface [polypeptide binding]; other site 507522015482 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 507522015483 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 507522015484 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522015485 transcriptional regulator SlyA; Provisional; Region: PRK03573 507522015486 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 507522015487 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 507522015488 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 507522015489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522015490 DNA-binding site [nucleotide binding]; DNA binding site 507522015491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522015492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522015493 homodimer interface [polypeptide binding]; other site 507522015494 catalytic residue [active] 507522015495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 507522015496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 507522015497 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 507522015498 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 507522015499 dimer interface [polypeptide binding]; other site 507522015500 Mn binding site [ion binding]; other site 507522015501 K binding site [ion binding]; other site 507522015502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522015503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522015504 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 507522015505 putative substrate binding pocket [chemical binding]; other site 507522015506 putative dimerization interface [polypeptide binding]; other site 507522015507 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 507522015508 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522015509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 507522015510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522015511 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 507522015512 DNA binding site [nucleotide binding] 507522015513 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522015514 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522015515 Hexamer interface [polypeptide binding]; other site 507522015516 Hexagonal pore residue; other site 507522015517 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522015518 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522015519 Hexamer interface [polypeptide binding]; other site 507522015520 Hexagonal pore residue; other site 507522015521 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522015522 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522015523 Hexamer interface [polypeptide binding]; other site 507522015524 Hexagonal pore residue; other site 507522015525 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 507522015526 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 507522015527 putative catalytic cysteine [active] 507522015528 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 507522015529 Hexamer/Pentamer interface [polypeptide binding]; other site 507522015530 central pore; other site 507522015531 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 507522015532 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 507522015533 putative active site [active] 507522015534 metal binding site [ion binding]; metal-binding site 507522015535 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 507522015536 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 507522015537 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 507522015538 dimer interface [polypeptide binding]; other site 507522015539 active site 507522015540 glycine loop; other site 507522015541 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 507522015542 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 507522015543 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 507522015544 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 507522015545 Hexamer interface [polypeptide binding]; other site 507522015546 Hexagonal pore residue; other site 507522015547 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 507522015548 Propanediol utilisation protein PduL; Region: PduL; pfam06130 507522015549 Propanediol utilisation protein PduL; Region: PduL; pfam06130 507522015550 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 507522015551 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 507522015552 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 507522015553 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 507522015554 active site 507522015555 HIGH motif; other site 507522015556 dimer interface [polypeptide binding]; other site 507522015557 KMSKS motif; other site 507522015558 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 507522015559 heme-binding site [chemical binding]; other site 507522015560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522015561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522015562 metal binding site [ion binding]; metal-binding site 507522015563 active site 507522015564 I-site; other site 507522015565 HlyD family secretion protein; Region: HlyD; pfam00529 507522015566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522015567 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522015568 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522015569 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 507522015570 Walker A/P-loop; other site 507522015571 ATP binding site [chemical binding]; other site 507522015572 Q-loop/lid; other site 507522015573 ABC transporter signature motif; other site 507522015574 Walker B; other site 507522015575 D-loop; other site 507522015576 H-loop/switch region; other site 507522015577 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 507522015578 Walker A/P-loop; other site 507522015579 ATP binding site [chemical binding]; other site 507522015580 Q-loop/lid; other site 507522015581 ABC transporter signature motif; other site 507522015582 Walker B; other site 507522015583 D-loop; other site 507522015584 H-loop/switch region; other site 507522015585 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522015586 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 507522015587 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 507522015588 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 507522015589 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 507522015590 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 507522015591 Uncharacterized conserved protein [Function unknown]; Region: COG2850 507522015592 sensor kinase CusS; Provisional; Region: PRK09835 507522015593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522015594 dimerization interface [polypeptide binding]; other site 507522015595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522015596 dimer interface [polypeptide binding]; other site 507522015597 phosphorylation site [posttranslational modification] 507522015598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522015599 ATP binding site [chemical binding]; other site 507522015600 Mg2+ binding site [ion binding]; other site 507522015601 G-X-G motif; other site 507522015602 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 507522015603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522015604 active site 507522015605 phosphorylation site [posttranslational modification] 507522015606 intermolecular recognition site; other site 507522015607 dimerization interface [polypeptide binding]; other site 507522015608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522015609 DNA binding site [nucleotide binding] 507522015610 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 507522015611 periplasmic copper-binding protein; Provisional; Region: PRK09838 507522015612 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 507522015613 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522015614 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 507522015615 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 507522015616 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 507522015617 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 507522015618 transcriptional regulator MirA; Provisional; Region: PRK15043 507522015619 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 507522015620 DNA binding residues [nucleotide binding] 507522015621 SnoaL-like domain; Region: SnoaL_2; pfam12680 507522015622 short chain dehydrogenase; Provisional; Region: PRK06101 507522015623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 507522015624 NAD(P) binding site [chemical binding]; other site 507522015625 active site 507522015626 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 507522015627 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 507522015628 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 507522015629 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 507522015630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522015631 S-adenosylmethionine binding site [chemical binding]; other site 507522015632 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 507522015633 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 507522015634 Protein of unknown function (DUF523); Region: DUF523; pfam04463 507522015635 Uncharacterized conserved protein [Function unknown]; Region: COG3272 507522015636 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 507522015637 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 507522015638 xylose isomerase; Provisional; Region: PRK05474 507522015639 xylose isomerase; Region: xylose_isom_A; TIGR02630 507522015640 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 507522015641 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 507522015642 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 507522015643 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 507522015644 inhibitor binding site; inhibition site 507522015645 active site 507522015646 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 507522015647 active site 507522015648 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 507522015649 HNH endonuclease; Region: HNH_2; pfam13391 507522015650 Protein of unknown function (DUF796); Region: DUF796; cl01226 507522015651 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 507522015652 putative active site [active] 507522015653 catalytic site [active] 507522015654 putative transposase OrfB; Reviewed; Region: PHA02517 507522015655 HTH-like domain; Region: HTH_21; pfam13276 507522015656 Integrase core domain; Region: rve; pfam00665 507522015657 Integrase core domain; Region: rve_3; pfam13683 507522015658 Transposase; Region: HTH_Tnp_1; pfam01527 507522015659 PAAR motif; Region: PAAR_motif; pfam05488 507522015660 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 507522015661 Protein of unknown function (DUF987); Region: DUF987; pfam06174 507522015662 hypothetical protein; Reviewed; Region: PRK00024 507522015663 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 507522015664 MPN+ (JAMM) motif; other site 507522015665 Zinc-binding site [ion binding]; other site 507522015666 Antirestriction protein; Region: Antirestrict; pfam03230 507522015667 Domain of unknown function (DUF932); Region: DUF932; pfam06067 507522015668 Predicted transcriptional regulator [Transcription]; Region: COG2378 507522015669 WYL domain; Region: WYL; pfam13280 507522015670 Predicted GTPase [General function prediction only]; Region: COG3596 507522015671 YfjP GTPase; Region: YfjP; cd11383 507522015672 G1 box; other site 507522015673 GTP/Mg2+ binding site [chemical binding]; other site 507522015674 Switch I region; other site 507522015675 G2 box; other site 507522015676 Switch II region; other site 507522015677 G3 box; other site 507522015678 G4 box; other site 507522015679 G5 box; other site 507522015680 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 507522015681 DNA-binding site [nucleotide binding]; DNA binding site 507522015682 RNA-binding motif; other site 507522015683 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 507522015684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 507522015685 Putative glucoamylase; Region: Glycoamylase; pfam10091 507522015686 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 507522015687 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 507522015688 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 507522015689 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 507522015690 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 507522015691 putative acyl-acceptor binding pocket; other site 507522015692 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 507522015693 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 507522015694 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 507522015695 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 507522015696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522015697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522015698 Coenzyme A binding pocket [chemical binding]; other site 507522015699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 507522015700 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 507522015701 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 507522015702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522015703 putative substrate translocation pore; other site 507522015704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 507522015705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522015706 hypothetical protein; Provisional; Region: PRK13687 507522015707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 507522015708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522015709 S-adenosylmethionine binding site [chemical binding]; other site 507522015710 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 507522015711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522015712 S-adenosylmethionine binding site [chemical binding]; other site 507522015713 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 507522015714 Protein of unknown function DUF45; Region: DUF45; pfam01863 507522015715 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 507522015716 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 507522015717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522015718 ATP binding site [chemical binding]; other site 507522015719 putative Mg++ binding site [ion binding]; other site 507522015720 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 507522015721 ADP-ribose binding site [chemical binding]; other site 507522015722 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 507522015723 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 507522015724 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 507522015725 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 507522015726 HsdM N-terminal domain; Region: HsdM_N; pfam12161 507522015727 Methyltransferase domain; Region: Methyltransf_26; pfam13659 507522015728 integrase; Provisional; Region: PRK09692 507522015729 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 507522015730 active site 507522015731 Int/Topo IB signature motif; other site 507522015732 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 507522015733 active site clefts [active] 507522015734 zinc binding site [ion binding]; other site 507522015735 dimer interface [polypeptide binding]; other site 507522015736 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 507522015737 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 507522015738 Sulfate transporter family; Region: Sulfate_transp; pfam00916 507522015739 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 507522015740 Sulfate transporter family; Region: Sulfate_transp; pfam00916 507522015741 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 507522015742 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 507522015743 putative NAD(P) binding site [chemical binding]; other site 507522015744 putative substrate binding site [chemical binding]; other site 507522015745 catalytic Zn binding site [ion binding]; other site 507522015746 structural Zn binding site [ion binding]; other site 507522015747 dimer interface [polypeptide binding]; other site 507522015748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522015749 dimer interface [polypeptide binding]; other site 507522015750 conserved gate region; other site 507522015751 putative PBP binding loops; other site 507522015752 ABC-ATPase subunit interface; other site 507522015753 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522015754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522015755 dimer interface [polypeptide binding]; other site 507522015756 conserved gate region; other site 507522015757 putative PBP binding loops; other site 507522015758 ABC-ATPase subunit interface; other site 507522015759 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 507522015760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 507522015761 active site 507522015762 metal binding site [ion binding]; metal-binding site 507522015763 hexamer interface [polypeptide binding]; other site 507522015764 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 507522015765 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 507522015766 Walker A/P-loop; other site 507522015767 ATP binding site [chemical binding]; other site 507522015768 Q-loop/lid; other site 507522015769 ABC transporter signature motif; other site 507522015770 Walker B; other site 507522015771 D-loop; other site 507522015772 H-loop/switch region; other site 507522015773 TOBE domain; Region: TOBE_2; pfam08402 507522015774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 507522015775 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 507522015776 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 507522015777 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 507522015778 Metal-binding active site; metal-binding site 507522015779 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 507522015780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 507522015781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 507522015782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 507522015783 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 507522015784 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522015785 PYR/PP interface [polypeptide binding]; other site 507522015786 dimer interface [polypeptide binding]; other site 507522015787 TPP binding site [chemical binding]; other site 507522015788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522015789 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 507522015790 TPP-binding site; other site 507522015791 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522015792 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 507522015793 substrate binding site [chemical binding]; other site 507522015794 ATP binding site [chemical binding]; other site 507522015795 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 507522015796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 507522015797 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 507522015798 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 507522015799 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 507522015800 putative active site [active] 507522015801 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 507522015802 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 507522015803 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 507522015804 tetrameric interface [polypeptide binding]; other site 507522015805 NAD binding site [chemical binding]; other site 507522015806 catalytic residues [active] 507522015807 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 507522015808 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 507522015809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 507522015810 Walker A motif; other site 507522015811 ATP binding site [chemical binding]; other site 507522015812 Walker B motif; other site 507522015813 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 507522015814 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 507522015815 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 507522015816 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 507522015817 multifunctional aminopeptidase A; Provisional; Region: PRK00913 507522015818 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 507522015819 interface (dimer of trimers) [polypeptide binding]; other site 507522015820 Substrate-binding/catalytic site; other site 507522015821 Zn-binding sites [ion binding]; other site 507522015822 DNA polymerase III subunit chi; Validated; Region: PRK05728 507522015823 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 507522015824 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 507522015825 HIGH motif; other site 507522015826 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 507522015827 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 507522015828 active site 507522015829 KMSKS motif; other site 507522015830 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 507522015831 tRNA binding surface [nucleotide binding]; other site 507522015832 anticodon binding site; other site 507522015833 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 507522015834 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 507522015835 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 507522015836 active site 507522015837 dinuclear metal binding site [ion binding]; other site 507522015838 dimerization interface [polypeptide binding]; other site 507522015839 RNase E inhibitor protein; Provisional; Region: PRK11191 507522015840 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 507522015841 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 507522015842 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 507522015843 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 507522015844 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 507522015845 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 507522015846 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 507522015847 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 507522015848 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 507522015849 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 507522015850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 507522015851 homotrimer interaction site [polypeptide binding]; other site 507522015852 putative active site [active] 507522015853 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 507522015854 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 507522015855 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 507522015856 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 507522015857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522015858 motif II; other site 507522015859 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 507522015860 trehalose repressor; Provisional; Region: treR; PRK09492 507522015861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522015862 DNA binding site [nucleotide binding] 507522015863 domain linker motif; other site 507522015864 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 507522015865 dimerization interface [polypeptide binding]; other site 507522015866 ligand binding site [chemical binding]; other site 507522015867 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 507522015868 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522015869 active site turn [active] 507522015870 phosphorylation site [posttranslational modification] 507522015871 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522015872 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 507522015873 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 507522015874 Ca binding site [ion binding]; other site 507522015875 active site 507522015876 catalytic site [active] 507522015877 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 507522015878 ATP cone domain; Region: ATP-cone; pfam03477 507522015879 Class III ribonucleotide reductase; Region: RNR_III; cd01675 507522015880 effector binding site; other site 507522015881 active site 507522015882 Zn binding site [ion binding]; other site 507522015883 glycine loop; other site 507522015884 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 507522015885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522015886 FeS/SAM binding site; other site 507522015887 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 507522015888 HTH domain; Region: HTH_11; pfam08279 507522015889 Mga helix-turn-helix domain; Region: Mga; pfam05043 507522015890 PRD domain; Region: PRD; pfam00874 507522015891 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 507522015892 active site 507522015893 P-loop; other site 507522015894 phosphorylation site [posttranslational modification] 507522015895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522015896 active site 507522015897 phosphorylation site [posttranslational modification] 507522015898 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 507522015899 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 507522015900 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 507522015901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 507522015902 catalytic residue [active] 507522015903 dihydroorotase; Provisional; Region: PRK09237 507522015904 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 507522015905 active site 507522015906 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 507522015907 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 507522015908 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 507522015909 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 507522015910 Cytochrome b562; Region: Cytochrom_B562; cl01546 507522015911 peptidase PmbA; Provisional; Region: PRK11040 507522015912 hypothetical protein; Provisional; Region: PRK05255 507522015913 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 507522015914 active site 507522015915 catalytic residues [active] 507522015916 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 507522015917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522015918 Coenzyme A binding pocket [chemical binding]; other site 507522015919 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 507522015920 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 507522015921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 507522015922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 507522015923 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 507522015924 AMP binding site [chemical binding]; other site 507522015925 metal binding site [ion binding]; metal-binding site 507522015926 active site 507522015927 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522015928 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522015929 TM-ABC transporter signature motif; other site 507522015930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522015931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522015932 TM-ABC transporter signature motif; other site 507522015933 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522015934 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522015935 Walker A/P-loop; other site 507522015936 ATP binding site [chemical binding]; other site 507522015937 Q-loop/lid; other site 507522015938 ABC transporter signature motif; other site 507522015939 Walker B; other site 507522015940 D-loop; other site 507522015941 H-loop/switch region; other site 507522015942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522015943 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 507522015944 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 507522015945 putative ligand binding site [chemical binding]; other site 507522015946 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 507522015947 dimer interface [polypeptide binding]; other site 507522015948 substrate binding site [chemical binding]; other site 507522015949 metal binding sites [ion binding]; metal-binding site 507522015950 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 507522015951 putative active site pocket [active] 507522015952 dimerization interface [polypeptide binding]; other site 507522015953 putative catalytic residue [active] 507522015954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 507522015955 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 507522015956 Family of unknown function (DUF490); Region: DUF490; pfam04357 507522015957 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 507522015958 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522015959 Surface antigen; Region: Bac_surface_Ag; pfam01103 507522015960 methionine sulfoxide reductase A; Provisional; Region: PRK00058 507522015961 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 507522015962 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 507522015963 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 507522015964 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 507522015965 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 507522015966 inhibitor site; inhibition site 507522015967 active site 507522015968 dimer interface [polypeptide binding]; other site 507522015969 catalytic residue [active] 507522015970 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522015971 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522015972 DNA binding site [nucleotide binding] 507522015973 domain linker motif; other site 507522015974 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 507522015975 putative dimerization interface [polypeptide binding]; other site 507522015976 putative ligand binding site [chemical binding]; other site 507522015977 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 507522015978 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 507522015979 Domain of unknown function DUF21; Region: DUF21; pfam01595 507522015980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 507522015981 Transporter associated domain; Region: CorC_HlyC; smart01091 507522015982 galactoside permease; Reviewed; Region: lacY; PRK09528 507522015983 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 507522015984 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 507522015985 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 507522015986 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 507522015987 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522015988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522015990 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 507522015991 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 507522015992 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 507522015993 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 507522015994 active site 507522015995 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 507522015996 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 507522015997 active site 507522015998 metal binding site [ion binding]; metal-binding site 507522015999 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 507522016000 Predicted transcriptional regulators [Transcription]; Region: COG1733 507522016001 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 507522016002 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 507522016003 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 507522016004 NADP binding site [chemical binding]; other site 507522016005 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522016006 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 507522016007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522016008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522016009 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 507522016010 EamA-like transporter family; Region: EamA; pfam00892 507522016011 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 507522016012 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 507522016013 Hemerythrin-like domain; Region: Hr-like; cd12108 507522016014 Fe binding site [ion binding]; other site 507522016015 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 507522016016 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 507522016017 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 507522016018 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 507522016019 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 507522016020 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 507522016021 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 507522016022 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 507522016023 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 507522016024 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 507522016025 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 507522016026 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522016027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522016028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 507522016029 putative substrate translocation pore; other site 507522016030 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 507522016031 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 507522016032 intersubunit interface [polypeptide binding]; other site 507522016033 active site 507522016034 Zn2+ binding site [ion binding]; other site 507522016035 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 507522016036 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 507522016037 AP (apurinic/apyrimidinic) site pocket; other site 507522016038 DNA interaction; other site 507522016039 Metal-binding active site; metal-binding site 507522016040 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 507522016041 active site 507522016042 dimer interface [polypeptide binding]; other site 507522016043 magnesium binding site [ion binding]; other site 507522016044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522016045 active site 507522016046 phosphorylation site [posttranslational modification] 507522016047 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 507522016048 active site 507522016049 P-loop; other site 507522016050 phosphorylation site [posttranslational modification] 507522016051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 507522016052 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 507522016053 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 507522016054 transcriptional repressor UlaR; Provisional; Region: PRK13509 507522016055 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 507522016056 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 507522016057 esterase; Provisional; Region: PRK10566 507522016058 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522016059 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 507522016060 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 507522016061 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 507522016062 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 507522016063 FAD binding site [chemical binding]; other site 507522016064 substrate binding site [chemical binding]; other site 507522016065 catalytic residues [active] 507522016066 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 507522016067 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 507522016068 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 507522016069 exoribonuclease R; Provisional; Region: PRK11642 507522016070 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 507522016071 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 507522016072 RNB domain; Region: RNB; pfam00773 507522016073 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 507522016074 RNA binding site [nucleotide binding]; other site 507522016075 Predicted transcriptional regulator [Transcription]; Region: COG1959 507522016076 transcriptional repressor NsrR; Provisional; Region: PRK11014 507522016077 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 507522016078 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 507522016079 GDP-binding site [chemical binding]; other site 507522016080 ACT binding site; other site 507522016081 IMP binding site; other site 507522016082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 507522016083 FtsH protease regulator HflC; Provisional; Region: PRK11029 507522016084 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 507522016085 FtsH protease regulator HflK; Provisional; Region: PRK10930 507522016086 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 507522016087 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 507522016088 GTPase HflX; Provisional; Region: PRK11058 507522016089 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 507522016090 HflX GTPase family; Region: HflX; cd01878 507522016091 G1 box; other site 507522016092 GTP/Mg2+ binding site [chemical binding]; other site 507522016093 Switch I region; other site 507522016094 G2 box; other site 507522016095 G3 box; other site 507522016096 Switch II region; other site 507522016097 G4 box; other site 507522016098 G5 box; other site 507522016099 bacterial Hfq-like; Region: Hfq; cd01716 507522016100 hexamer interface [polypeptide binding]; other site 507522016101 Sm1 motif; other site 507522016102 RNA binding site [nucleotide binding]; other site 507522016103 Sm2 motif; other site 507522016104 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 507522016105 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 507522016106 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 507522016107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522016108 ATP binding site [chemical binding]; other site 507522016109 Mg2+ binding site [ion binding]; other site 507522016110 G-X-G motif; other site 507522016111 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 507522016112 ATP binding site [chemical binding]; other site 507522016113 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 507522016114 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 507522016115 AMIN domain; Region: AMIN; pfam11741 507522016116 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 507522016117 active site 507522016118 metal binding site [ion binding]; metal-binding site 507522016119 ADP-binding protein; Provisional; Region: PRK10646 507522016120 putative carbohydrate kinase; Provisional; Region: PRK10565 507522016121 Uncharacterized conserved protein [Function unknown]; Region: COG0062 507522016122 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 507522016123 putative substrate binding site [chemical binding]; other site 507522016124 putative ATP binding site [chemical binding]; other site 507522016125 epoxyqueuosine reductase; Region: TIGR00276 507522016126 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 507522016127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 507522016128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522016129 substrate binding pocket [chemical binding]; other site 507522016130 membrane-bound complex binding site; other site 507522016131 hinge residues; other site 507522016132 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 507522016133 catalytic site [active] 507522016134 putative active site [active] 507522016135 putative substrate binding site [chemical binding]; other site 507522016136 dimer interface [polypeptide binding]; other site 507522016137 GTPase RsgA; Reviewed; Region: PRK12288 507522016138 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 507522016139 RNA binding site [nucleotide binding]; other site 507522016140 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 507522016141 GTPase/Zn-binding domain interface [polypeptide binding]; other site 507522016142 GTP/Mg2+ binding site [chemical binding]; other site 507522016143 G4 box; other site 507522016144 G5 box; other site 507522016145 G1 box; other site 507522016146 Switch I region; other site 507522016147 G2 box; other site 507522016148 G3 box; other site 507522016149 Switch II region; other site 507522016150 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 507522016151 putative mechanosensitive channel protein; Provisional; Region: PRK10929 507522016152 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 507522016153 putative YPXnL-motif binding site; other site 507522016154 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 507522016155 Mechanosensitive ion channel; Region: MS_channel; pfam00924 507522016156 inner membrane transporter YjeM; Provisional; Region: PRK15238 507522016157 poxB regulator PoxA; Provisional; Region: PRK09350 507522016158 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 507522016159 motif 1; other site 507522016160 dimer interface [polypeptide binding]; other site 507522016161 active site 507522016162 motif 2; other site 507522016163 motif 3; other site 507522016164 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 507522016165 L-aspartate oxidase; Provisional; Region: PRK06175 507522016166 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 507522016167 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 507522016168 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 507522016169 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 507522016170 D-subunit interface [polypeptide binding]; other site 507522016171 Iron-sulfur protein interface; other site 507522016172 proximal quinone binding site [chemical binding]; other site 507522016173 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 507522016174 Iron-sulfur protein interface; other site 507522016175 proximal quinone binding site [chemical binding]; other site 507522016176 C-subunit interface; other site 507522016177 distal quinone binding site; other site 507522016178 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 507522016179 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 507522016180 multidrug efflux system protein; Provisional; Region: PRK11431 507522016181 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 507522016182 Predicted small secreted protein [Function unknown]; Region: COG5510 507522016183 elongation factor P; Validated; Region: PRK00529 507522016184 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 507522016185 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 507522016186 RNA binding site [nucleotide binding]; other site 507522016187 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 507522016188 RNA binding site [nucleotide binding]; other site 507522016189 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 507522016190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522016191 FeS/SAM binding site; other site 507522016192 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 507522016193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 507522016194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 507522016195 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 507522016196 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522016197 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522016198 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522016199 PapC N-terminal domain; Region: PapC_N; pfam13954 507522016200 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522016201 PapC C-terminal domain; Region: PapC_C; pfam13953 507522016202 Fimbrial protein; Region: Fimbrial; pfam00419 507522016203 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 507522016204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 507522016205 HlyD family secretion protein; Region: HlyD_3; pfam13437 507522016206 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 507522016207 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 507522016208 putative active site [active] 507522016209 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 507522016210 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 507522016211 Walker A/P-loop; other site 507522016212 ATP binding site [chemical binding]; other site 507522016213 Q-loop/lid; other site 507522016214 ABC transporter signature motif; other site 507522016215 Walker B; other site 507522016216 D-loop; other site 507522016217 H-loop/switch region; other site 507522016218 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 507522016219 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 507522016220 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 507522016221 ring oligomerisation interface [polypeptide binding]; other site 507522016222 ATP/Mg binding site [chemical binding]; other site 507522016223 stacking interactions; other site 507522016224 hinge regions; other site 507522016225 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 507522016226 oligomerisation interface [polypeptide binding]; other site 507522016227 mobile loop; other site 507522016228 roof hairpin; other site 507522016229 putative transporter; Provisional; Region: PRK11021 507522016230 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 507522016231 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 507522016232 Aspartase; Region: Aspartase; cd01357 507522016233 active sites [active] 507522016234 tetramer interface [polypeptide binding]; other site 507522016235 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 507522016236 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 507522016237 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 507522016238 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 507522016239 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 507522016240 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 507522016241 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 507522016242 DsbD alpha interface [polypeptide binding]; other site 507522016243 catalytic residues [active] 507522016244 putative transcriptional regulator; Provisional; Region: PRK11640 507522016245 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 507522016246 PerC transcriptional activator; Region: PerC; pfam06069 507522016247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 507522016248 dimerization interface [polypeptide binding]; other site 507522016249 DNA binding residues [nucleotide binding] 507522016250 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 507522016251 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 507522016252 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 507522016253 putative active site [active] 507522016254 putative metal binding site [ion binding]; other site 507522016255 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 507522016256 N-glycosyltransferase; Provisional; Region: PRK11204 507522016257 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 507522016258 DXD motif; other site 507522016259 hemin storage system protein; Provisional; Region: hmsS; PRK14584 507522016260 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 507522016261 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 507522016262 catalytic residues [active] 507522016263 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 507522016264 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 507522016265 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 507522016266 HSP70 interaction site [polypeptide binding]; other site 507522016267 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 507522016268 substrate binding site [polypeptide binding]; other site 507522016269 dimer interface [polypeptide binding]; other site 507522016270 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 507522016271 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 507522016272 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 507522016273 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 507522016274 PRTRC system protein D; Region: PRTRC_D; TIGR03739 507522016275 Mg binding site [ion binding]; other site 507522016276 nucleotide binding site [chemical binding]; other site 507522016277 putative protofilament interface [polypeptide binding]; other site 507522016278 melibiose:sodium symporter; Provisional; Region: PRK10429 507522016279 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 507522016280 alpha-galactosidase; Provisional; Region: PRK15076 507522016281 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 507522016282 NAD binding site [chemical binding]; other site 507522016283 sugar binding site [chemical binding]; other site 507522016284 divalent metal binding site [ion binding]; other site 507522016285 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522016286 dimer interface [polypeptide binding]; other site 507522016287 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 507522016288 Cupin domain; Region: Cupin_2; cl17218 507522016289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522016290 proline/glycine betaine transporter; Provisional; Region: PRK10642 507522016291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522016292 putative substrate translocation pore; other site 507522016293 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 507522016294 hypothetical protein; Provisional; Region: PRK10220 507522016295 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 507522016296 PhnA protein; Region: PhnA; pfam03831 507522016297 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 507522016298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 507522016299 dimer interface [polypeptide binding]; other site 507522016300 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 507522016301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522016302 DNA-binding site [nucleotide binding]; DNA binding site 507522016303 UTRA domain; Region: UTRA; pfam07702 507522016304 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 507522016305 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 507522016306 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 507522016307 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 507522016308 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 507522016309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 507522016310 Walker A/P-loop; other site 507522016311 ATP binding site [chemical binding]; other site 507522016312 Q-loop/lid; other site 507522016313 ABC transporter signature motif; other site 507522016314 Walker B; other site 507522016315 D-loop; other site 507522016316 H-loop/switch region; other site 507522016317 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 507522016318 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 507522016319 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 507522016320 Walker A/P-loop; other site 507522016321 ATP binding site [chemical binding]; other site 507522016322 Q-loop/lid; other site 507522016323 ABC transporter signature motif; other site 507522016324 Walker B; other site 507522016325 D-loop; other site 507522016326 H-loop/switch region; other site 507522016327 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 507522016328 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522016329 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 507522016330 active site 507522016331 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 507522016332 active site 507522016333 putative hydrolase; Provisional; Region: PRK02113 507522016334 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 507522016335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522016336 dimerization interface [polypeptide binding]; other site 507522016337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522016338 dimer interface [polypeptide binding]; other site 507522016339 phosphorylation site [posttranslational modification] 507522016340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522016341 ATP binding site [chemical binding]; other site 507522016342 Mg2+ binding site [ion binding]; other site 507522016343 G-X-G motif; other site 507522016344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522016345 active site 507522016346 phosphorylation site [posttranslational modification] 507522016347 intermolecular recognition site; other site 507522016348 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522016349 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522016350 Walker A/P-loop; other site 507522016351 ATP binding site [chemical binding]; other site 507522016352 Q-loop/lid; other site 507522016353 ABC transporter signature motif; other site 507522016354 Walker B; other site 507522016355 D-loop; other site 507522016356 H-loop/switch region; other site 507522016357 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522016358 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522016359 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522016360 TM-ABC transporter signature motif; other site 507522016361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 507522016362 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 507522016363 putative ligand binding site [chemical binding]; other site 507522016364 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 507522016365 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522016366 substrate binding site [chemical binding]; other site 507522016367 ATP binding site [chemical binding]; other site 507522016368 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 507522016369 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 507522016370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 507522016371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522016372 active site 507522016373 phosphorylation site [posttranslational modification] 507522016374 intermolecular recognition site; other site 507522016375 dimerization interface [polypeptide binding]; other site 507522016376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522016377 DNA binding site [nucleotide binding] 507522016378 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 507522016379 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 507522016380 [4Fe-4S] binding site [ion binding]; other site 507522016381 molybdopterin cofactor binding site; other site 507522016382 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 507522016383 molybdopterin cofactor binding site; other site 507522016384 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 507522016385 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 507522016386 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 507522016387 acetyl-CoA synthetase; Provisional; Region: PRK00174 507522016388 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 507522016389 active site 507522016390 CoA binding site [chemical binding]; other site 507522016391 acyl-activating enzyme (AAE) consensus motif; other site 507522016392 AMP binding site [chemical binding]; other site 507522016393 acetate binding site [chemical binding]; other site 507522016394 Predicted membrane protein [Function unknown]; Region: COG3162 507522016395 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 507522016396 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 507522016397 Na binding site [ion binding]; other site 507522016398 putative major fimbrial protein SthE; Provisional; Region: PRK15292 507522016399 Fimbrial protein; Region: Fimbrial; cl01416 507522016400 Fimbrial protein; Region: Fimbrial; cl01416 507522016401 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 507522016402 PapC N-terminal domain; Region: PapC_N; pfam13954 507522016403 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 507522016404 PapC C-terminal domain; Region: PapC_C; pfam13953 507522016405 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 507522016406 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 507522016407 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 507522016408 Fimbrial protein; Region: Fimbrial; cl01416 507522016409 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 507522016410 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 507522016411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522016412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522016413 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 507522016414 putative dimerization interface [polypeptide binding]; other site 507522016415 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 507522016416 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 507522016417 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 507522016418 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 507522016419 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 507522016420 putative C-terminal domain interface [polypeptide binding]; other site 507522016421 putative GSH binding site (G-site) [chemical binding]; other site 507522016422 putative dimer interface [polypeptide binding]; other site 507522016423 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 507522016424 putative N-terminal domain interface [polypeptide binding]; other site 507522016425 putative dimer interface [polypeptide binding]; other site 507522016426 putative substrate binding pocket (H-site) [chemical binding]; other site 507522016427 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 507522016428 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 507522016429 DNA binding residues [nucleotide binding] 507522016430 dimer interface [polypeptide binding]; other site 507522016431 [2Fe-2S] cluster binding site [ion binding]; other site 507522016432 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 507522016433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522016434 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 507522016435 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 507522016436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 507522016437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 507522016438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522016439 dimer interface [polypeptide binding]; other site 507522016440 conserved gate region; other site 507522016441 putative PBP binding loops; other site 507522016442 ABC-ATPase subunit interface; other site 507522016443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522016444 dimer interface [polypeptide binding]; other site 507522016445 conserved gate region; other site 507522016446 putative PBP binding loops; other site 507522016447 ABC-ATPase subunit interface; other site 507522016448 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 507522016449 hypothetical protein; Provisional; Region: PRK11622 507522016450 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 507522016451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 507522016452 Walker A/P-loop; other site 507522016453 ATP binding site [chemical binding]; other site 507522016454 Q-loop/lid; other site 507522016455 ABC transporter signature motif; other site 507522016456 Walker B; other site 507522016457 D-loop; other site 507522016458 H-loop/switch region; other site 507522016459 TOBE domain; Region: TOBE_2; pfam08402 507522016460 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 507522016461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522016462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 507522016463 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 507522016464 putative dimerization interface [polypeptide binding]; other site 507522016465 putative ligand binding site [chemical binding]; other site 507522016466 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 507522016467 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 507522016468 active site 507522016469 anti-adapter protein IraM; Provisional; Region: PRK09919 507522016470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522016471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522016472 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 507522016473 putative effector binding pocket; other site 507522016474 dimerization interface [polypeptide binding]; other site 507522016475 Major royal jelly protein; Region: MRJP; pfam03022 507522016476 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 507522016477 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522016478 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522016479 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522016480 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522016481 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 507522016482 Surface antigen; Region: Bac_surface_Ag; pfam01103 507522016483 Tannase and feruloyl esterase; Region: Tannase; pfam07519 507522016484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522016485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522016486 outer membrane receptor FepA; Provisional; Region: PRK13524 507522016487 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522016488 N-terminal plug; other site 507522016489 ligand-binding site [chemical binding]; other site 507522016490 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 507522016491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522016492 substrate binding pocket [chemical binding]; other site 507522016493 membrane-bound complex binding site; other site 507522016494 hinge residues; other site 507522016495 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 507522016496 N-acetyl-D-glucosamine binding site [chemical binding]; other site 507522016497 catalytic residue [active] 507522016498 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 507522016499 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 507522016500 dimer interface [polypeptide binding]; other site 507522016501 ssDNA binding site [nucleotide binding]; other site 507522016502 tetramer (dimer of dimers) interface [polypeptide binding]; other site 507522016503 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 507522016504 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 507522016505 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 507522016506 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 507522016507 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 507522016508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 507522016509 Uncharacterized conserved protein [Function unknown]; Region: COG0432 507522016510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522016511 active site 507522016512 motif I; other site 507522016513 motif II; other site 507522016514 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 507522016515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 507522016516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522016517 homodimer interface [polypeptide binding]; other site 507522016518 catalytic residue [active] 507522016519 alanine racemase; Reviewed; Region: alr; PRK00053 507522016520 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 507522016521 active site 507522016522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 507522016523 substrate binding site [chemical binding]; other site 507522016524 catalytic residues [active] 507522016525 dimer interface [polypeptide binding]; other site 507522016526 replicative DNA helicase; Provisional; Region: PRK08006 507522016527 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 507522016528 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 507522016529 Walker A motif; other site 507522016530 ATP binding site [chemical binding]; other site 507522016531 Walker B motif; other site 507522016532 DNA binding loops [nucleotide binding] 507522016533 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 507522016534 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 507522016535 NADP binding site [chemical binding]; other site 507522016536 dimer interface [polypeptide binding]; other site 507522016537 phage shock protein G; Reviewed; Region: pspG; PRK09459 507522016538 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 507522016539 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 507522016540 FMN binding site [chemical binding]; other site 507522016541 active site 507522016542 catalytic residues [active] 507522016543 substrate binding site [chemical binding]; other site 507522016544 Cupin domain; Region: Cupin_2; cl17218 507522016545 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 507522016546 metal binding site 2 [ion binding]; metal-binding site 507522016547 putative DNA binding helix; other site 507522016548 metal binding site 1 [ion binding]; metal-binding site 507522016549 dimer interface [polypeptide binding]; other site 507522016550 structural Zn2+ binding site [ion binding]; other site 507522016551 hypothetical protein; Provisional; Region: PRK10428 507522016552 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 507522016553 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 507522016554 LexA repressor; Validated; Region: PRK00215 507522016555 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 507522016556 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 507522016557 Catalytic site [active] 507522016558 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 507522016559 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 507522016560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 507522016561 putative acyl-acceptor binding pocket; other site 507522016562 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 507522016563 UbiA prenyltransferase family; Region: UbiA; pfam01040 507522016564 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 507522016565 maltose regulon periplasmic protein; Provisional; Region: PRK10564 507522016566 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522016567 trimer interface; other site 507522016568 sugar binding site [chemical binding]; other site 507522016569 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 507522016570 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 507522016571 Walker A/P-loop; other site 507522016572 ATP binding site [chemical binding]; other site 507522016573 Q-loop/lid; other site 507522016574 ABC transporter signature motif; other site 507522016575 Walker B; other site 507522016576 D-loop; other site 507522016577 H-loop/switch region; other site 507522016578 TOBE domain; Region: TOBE_2; pfam08402 507522016579 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 507522016580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 507522016581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522016582 dimer interface [polypeptide binding]; other site 507522016583 conserved gate region; other site 507522016584 putative PBP binding loops; other site 507522016585 ABC-ATPase subunit interface; other site 507522016586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 507522016587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522016588 dimer interface [polypeptide binding]; other site 507522016589 conserved gate region; other site 507522016590 putative PBP binding loops; other site 507522016591 ABC-ATPase subunit interface; other site 507522016592 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 507522016593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522016594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522016595 Coenzyme A binding pocket [chemical binding]; other site 507522016596 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 507522016597 putative trimer interface [polypeptide binding]; other site 507522016598 putative active site [active] 507522016599 putative substrate binding site [chemical binding]; other site 507522016600 putative CoA binding site [chemical binding]; other site 507522016601 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 507522016602 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 507522016603 active site 507522016604 dimer interface [polypeptide binding]; other site 507522016605 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 507522016606 dimer interface [polypeptide binding]; other site 507522016607 active site 507522016608 aspartate kinase III; Validated; Region: PRK09084 507522016609 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 507522016610 nucleotide binding site [chemical binding]; other site 507522016611 substrate binding site [chemical binding]; other site 507522016612 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 507522016613 lysine allosteric regulatory site; other site 507522016614 dimer interface [polypeptide binding]; other site 507522016615 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 507522016616 dimer interface [polypeptide binding]; other site 507522016617 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 507522016618 Sodium Bile acid symporter family; Region: SBF; pfam01758 507522016619 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 507522016620 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 507522016621 hypothetical protein; Provisional; Region: PRK10515 507522016622 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 507522016623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 507522016624 RNA binding surface [nucleotide binding]; other site 507522016625 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 507522016626 probable active site [active] 507522016627 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 507522016628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522016629 putative DNA binding site [nucleotide binding]; other site 507522016630 putative Zn2+ binding site [ion binding]; other site 507522016631 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 507522016632 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 507522016633 classical (c) SDRs; Region: SDR_c; cd05233 507522016634 NAD(P) binding site [chemical binding]; other site 507522016635 active site 507522016636 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 507522016637 active pocket/dimerization site; other site 507522016638 active site 507522016639 phosphorylation site [posttranslational modification] 507522016640 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 507522016641 active site 507522016642 phosphorylation site [posttranslational modification] 507522016643 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 507522016644 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 507522016645 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 507522016646 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 507522016647 putative NAD(P) binding site [chemical binding]; other site 507522016648 catalytic Zn binding site [ion binding]; other site 507522016649 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 507522016650 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 507522016651 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 507522016652 shikimate binding site; other site 507522016653 NAD(P) binding site [chemical binding]; other site 507522016654 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 507522016655 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 507522016656 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 507522016657 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 507522016658 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 507522016659 substrate binding pocket [chemical binding]; other site 507522016660 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 507522016661 B12 binding site [chemical binding]; other site 507522016662 cobalt ligand [ion binding]; other site 507522016663 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 507522016664 transcriptional repressor IclR; Provisional; Region: PRK11569 507522016665 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 507522016666 Bacterial transcriptional regulator; Region: IclR; pfam01614 507522016667 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 507522016668 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 507522016669 isocitrate lyase; Provisional; Region: PRK15063 507522016670 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 507522016671 tetramer interface [polypeptide binding]; other site 507522016672 active site 507522016673 Mg2+/Mn2+ binding site [ion binding]; other site 507522016674 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 507522016675 malate synthase A; Region: malate_syn_A; TIGR01344 507522016676 active site 507522016677 homoserine O-succinyltransferase; Provisional; Region: PRK05368 507522016678 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 507522016679 proposed active site lysine [active] 507522016680 conserved cys residue [active] 507522016681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 507522016682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522016683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 507522016684 Coenzyme A binding pocket [chemical binding]; other site 507522016685 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 507522016686 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 507522016687 purine monophosphate binding site [chemical binding]; other site 507522016688 dimer interface [polypeptide binding]; other site 507522016689 putative catalytic residues [active] 507522016690 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 507522016691 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 507522016692 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 507522016693 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 507522016694 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 507522016695 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 507522016696 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 507522016697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522016698 active site 507522016699 phosphorylation site [posttranslational modification] 507522016700 intermolecular recognition site; other site 507522016701 dimerization interface [polypeptide binding]; other site 507522016702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522016703 Walker A motif; other site 507522016704 ATP binding site [chemical binding]; other site 507522016705 Walker B motif; other site 507522016706 arginine finger; other site 507522016707 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522016708 sensor protein ZraS; Provisional; Region: PRK10364 507522016709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522016710 dimer interface [polypeptide binding]; other site 507522016711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522016712 ATP binding site [chemical binding]; other site 507522016713 Mg2+ binding site [ion binding]; other site 507522016714 G-X-G motif; other site 507522016715 zinc resistance protein; Provisional; Region: zraP; PRK11546 507522016716 dimer interface [polypeptide binding]; other site 507522016717 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 507522016718 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 507522016719 IHF dimer interface [polypeptide binding]; other site 507522016720 IHF - DNA interface [nucleotide binding]; other site 507522016721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 507522016722 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 507522016723 Active_site [active] 507522016724 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 507522016725 substrate binding site [chemical binding]; other site 507522016726 active site 507522016727 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 507522016728 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 507522016729 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 507522016730 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 507522016731 putative NADH binding site [chemical binding]; other site 507522016732 putative active site [active] 507522016733 nudix motif; other site 507522016734 putative metal binding site [ion binding]; other site 507522016735 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 507522016736 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 507522016737 ThiC-associated domain; Region: ThiC-associated; pfam13667 507522016738 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 507522016739 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 507522016740 thiamine phosphate binding site [chemical binding]; other site 507522016741 active site 507522016742 pyrophosphate binding site [ion binding]; other site 507522016743 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 507522016744 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 507522016745 ATP binding site [chemical binding]; other site 507522016746 substrate interface [chemical binding]; other site 507522016747 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 507522016748 thiS-thiF/thiG interaction site; other site 507522016749 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 507522016750 ThiS interaction site; other site 507522016751 putative active site [active] 507522016752 tetramer interface [polypeptide binding]; other site 507522016753 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 507522016754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522016755 FeS/SAM binding site; other site 507522016756 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 507522016757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 507522016758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 507522016759 metal binding site [ion binding]; metal-binding site 507522016760 active site 507522016761 I-site; other site 507522016762 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 507522016763 active site 507522016764 P-loop; other site 507522016765 phosphorylation site [posttranslational modification] 507522016766 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 507522016767 methionine cluster; other site 507522016768 active site 507522016769 phosphorylation site [posttranslational modification] 507522016770 metal binding site [ion binding]; metal-binding site 507522016771 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 507522016772 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 507522016773 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 507522016774 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 507522016775 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 507522016776 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 507522016777 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 507522016778 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 507522016779 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 507522016780 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 507522016781 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 507522016782 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 507522016783 DNA binding site [nucleotide binding] 507522016784 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 507522016785 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 507522016786 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 507522016787 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 507522016788 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 507522016789 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 507522016790 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 507522016791 RPB3 interaction site [polypeptide binding]; other site 507522016792 RPB1 interaction site [polypeptide binding]; other site 507522016793 RPB11 interaction site [polypeptide binding]; other site 507522016794 RPB10 interaction site [polypeptide binding]; other site 507522016795 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 507522016796 core dimer interface [polypeptide binding]; other site 507522016797 peripheral dimer interface [polypeptide binding]; other site 507522016798 L10 interface [polypeptide binding]; other site 507522016799 L11 interface [polypeptide binding]; other site 507522016800 putative EF-Tu interaction site [polypeptide binding]; other site 507522016801 putative EF-G interaction site [polypeptide binding]; other site 507522016802 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 507522016803 23S rRNA interface [nucleotide binding]; other site 507522016804 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 507522016805 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 507522016806 mRNA/rRNA interface [nucleotide binding]; other site 507522016807 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 507522016808 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 507522016809 23S rRNA interface [nucleotide binding]; other site 507522016810 L7/L12 interface [polypeptide binding]; other site 507522016811 putative thiostrepton binding site; other site 507522016812 L25 interface [polypeptide binding]; other site 507522016813 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 507522016814 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 507522016815 putative homodimer interface [polypeptide binding]; other site 507522016816 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 507522016817 heterodimer interface [polypeptide binding]; other site 507522016818 homodimer interface [polypeptide binding]; other site 507522016819 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 507522016820 elongation factor Tu; Reviewed; Region: PRK00049 507522016821 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 507522016822 G1 box; other site 507522016823 GEF interaction site [polypeptide binding]; other site 507522016824 GTP/Mg2+ binding site [chemical binding]; other site 507522016825 Switch I region; other site 507522016826 G2 box; other site 507522016827 G3 box; other site 507522016828 Switch II region; other site 507522016829 G4 box; other site 507522016830 G5 box; other site 507522016831 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 507522016832 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 507522016833 Antibiotic Binding Site [chemical binding]; other site 507522016834 pantothenate kinase; Provisional; Region: PRK05439 507522016835 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 507522016836 ATP-binding site [chemical binding]; other site 507522016837 CoA-binding site [chemical binding]; other site 507522016838 Mg2+-binding site [ion binding]; other site 507522016839 Biotin operon repressor [Transcription]; Region: BirA; COG1654 507522016840 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 507522016841 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 507522016842 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 507522016843 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 507522016844 FAD binding domain; Region: FAD_binding_4; pfam01565 507522016845 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 507522016846 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 507522016847 potassium transporter; Provisional; Region: PRK10750 507522016848 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 507522016849 hypothetical protein; Provisional; Region: PRK11568 507522016850 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 507522016851 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 507522016852 proline dipeptidase; Provisional; Region: PRK13607 507522016853 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 507522016854 active site 507522016855 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 507522016856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 507522016857 substrate binding site [chemical binding]; other site 507522016858 oxyanion hole (OAH) forming residues; other site 507522016859 trimer interface [polypeptide binding]; other site 507522016860 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 507522016861 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522016862 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 507522016863 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 507522016864 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 507522016865 dimer interface [polypeptide binding]; other site 507522016866 active site 507522016867 FMN reductase; Validated; Region: fre; PRK08051 507522016868 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 507522016869 FAD binding pocket [chemical binding]; other site 507522016870 FAD binding motif [chemical binding]; other site 507522016871 phosphate binding motif [ion binding]; other site 507522016872 beta-alpha-beta structure motif; other site 507522016873 NAD binding pocket [chemical binding]; other site 507522016874 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 507522016875 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 507522016876 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 507522016877 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 507522016878 active site 507522016879 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 507522016880 sec-independent translocase; Provisional; Region: PRK01770 507522016881 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 507522016882 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 507522016883 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 507522016884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 507522016885 SCP-2 sterol transfer family; Region: SCP2; pfam02036 507522016886 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 507522016887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522016888 S-adenosylmethionine binding site [chemical binding]; other site 507522016889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 507522016890 DNA recombination protein RmuC; Provisional; Region: PRK10361 507522016891 RmuC family; Region: RmuC; pfam02646 507522016892 uridine phosphorylase; Provisional; Region: PRK11178 507522016893 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 507522016894 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 507522016895 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 507522016896 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 507522016897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522016898 FeS/SAM binding site; other site 507522016899 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 507522016900 Domain of unknown function (DUF202); Region: DUF202; cl09954 507522016901 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 507522016902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522016903 DNA-binding site [nucleotide binding]; DNA binding site 507522016904 UTRA domain; Region: UTRA; pfam07702 507522016905 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 507522016906 Sulfatase; Region: Sulfatase; cl17466 507522016907 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 507522016908 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 507522016909 active site turn [active] 507522016910 phosphorylation site [posttranslational modification] 507522016911 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 507522016912 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 507522016913 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 507522016914 THF binding site; other site 507522016915 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 507522016916 substrate binding site [chemical binding]; other site 507522016917 THF binding site; other site 507522016918 zinc-binding site [ion binding]; other site 507522016919 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 507522016920 EamA-like transporter family; Region: EamA; pfam00892 507522016921 putative hydrolase; Provisional; Region: PRK10976 507522016922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522016923 active site 507522016924 motif I; other site 507522016925 motif II; other site 507522016926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522016927 lysophospholipase L2; Provisional; Region: PRK10749 507522016928 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 507522016929 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 507522016930 putative transposase; Provisional; Region: PRK09857 507522016931 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 507522016932 threonine efflux system; Provisional; Region: PRK10229 507522016933 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 507522016934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522016935 ATP binding site [chemical binding]; other site 507522016936 putative Mg++ binding site [ion binding]; other site 507522016937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522016938 nucleotide binding region [chemical binding]; other site 507522016939 ATP-binding site [chemical binding]; other site 507522016940 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 507522016941 HRDC domain; Region: HRDC; pfam00570 507522016942 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 507522016943 dimerization interface [polypeptide binding]; other site 507522016944 substrate binding site [chemical binding]; other site 507522016945 active site 507522016946 calcium binding site [ion binding]; other site 507522016947 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 507522016948 CoenzymeA binding site [chemical binding]; other site 507522016949 subunit interaction site [polypeptide binding]; other site 507522016950 PHB binding site; other site 507522016951 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 507522016952 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 507522016953 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 507522016954 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 507522016955 Cl binding site [ion binding]; other site 507522016956 oligomer interface [polypeptide binding]; other site 507522016957 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 507522016958 Part of AAA domain; Region: AAA_19; pfam13245 507522016959 Family description; Region: UvrD_C_2; pfam13538 507522016960 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 507522016961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522016962 motif II; other site 507522016963 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 507522016964 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 507522016965 active site 507522016966 Int/Topo IB signature motif; other site 507522016967 hypothetical protein; Provisional; Region: PRK10963 507522016968 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 507522016969 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 507522016970 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 507522016971 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 507522016972 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 507522016973 putative iron binding site [ion binding]; other site 507522016974 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 507522016975 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 507522016976 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 507522016977 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 507522016978 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 507522016979 domain interfaces; other site 507522016980 active site 507522016981 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 507522016982 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 507522016983 active site 507522016984 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 507522016985 HemX; Region: HemX; pfam04375 507522016986 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 507522016987 HemY protein N-terminus; Region: HemY_N; pfam07219 507522016988 putative transport protein YifK; Provisional; Region: PRK10746 507522016989 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 507522016990 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 507522016991 putative common antigen polymerase; Provisional; Region: PRK02975 507522016992 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 507522016993 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 507522016994 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 507522016995 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 507522016996 inhibitor-cofactor binding pocket; inhibition site 507522016997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522016998 catalytic residue [active] 507522016999 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 507522017000 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 507522017001 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 507522017002 substrate binding site; other site 507522017003 tetramer interface; other site 507522017004 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 507522017005 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 507522017006 NAD binding site [chemical binding]; other site 507522017007 substrate binding site [chemical binding]; other site 507522017008 homodimer interface [polypeptide binding]; other site 507522017009 active site 507522017010 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 507522017011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 507522017012 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 507522017013 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 507522017014 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 507522017015 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 507522017016 active site 507522017017 homodimer interface [polypeptide binding]; other site 507522017018 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 507522017019 Chain length determinant protein; Region: Wzz; pfam02706 507522017020 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 507522017021 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 507522017022 Mg++ binding site [ion binding]; other site 507522017023 putative catalytic motif [active] 507522017024 substrate binding site [chemical binding]; other site 507522017025 transcription termination factor Rho; Provisional; Region: rho; PRK09376 507522017026 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 507522017027 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 507522017028 RNA binding site [nucleotide binding]; other site 507522017029 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 507522017030 multimer interface [polypeptide binding]; other site 507522017031 Walker A motif; other site 507522017032 ATP binding site [chemical binding]; other site 507522017033 Walker B motif; other site 507522017034 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 507522017035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 507522017036 catalytic residues [active] 507522017037 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 507522017038 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 507522017039 ATP binding site [chemical binding]; other site 507522017040 Mg++ binding site [ion binding]; other site 507522017041 motif III; other site 507522017042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 507522017043 nucleotide binding region [chemical binding]; other site 507522017044 ATP-binding site [chemical binding]; other site 507522017045 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 507522017046 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 507522017047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 507522017048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017049 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 507522017050 substrate binding pocket [chemical binding]; other site 507522017051 dimerization interface [polypeptide binding]; other site 507522017052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 507522017053 Protein of unknown function (DUF554); Region: DUF554; pfam04474 507522017054 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 507522017055 Part of AAA domain; Region: AAA_19; pfam13245 507522017056 Family description; Region: UvrD_C_2; pfam13538 507522017057 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 507522017058 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 507522017059 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 507522017060 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 507522017061 ketol-acid reductoisomerase; Validated; Region: PRK05225 507522017062 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 507522017063 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 507522017064 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 507522017065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017066 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 507522017067 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 507522017068 putative dimerization interface [polypeptide binding]; other site 507522017069 threonine dehydratase; Reviewed; Region: PRK09224 507522017070 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 507522017071 tetramer interface [polypeptide binding]; other site 507522017072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522017073 catalytic residue [active] 507522017074 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 507522017075 putative Ile/Val binding site [chemical binding]; other site 507522017076 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 507522017077 putative Ile/Val binding site [chemical binding]; other site 507522017078 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 507522017079 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 507522017080 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 507522017081 homodimer interface [polypeptide binding]; other site 507522017082 substrate-cofactor binding pocket; other site 507522017083 catalytic residue [active] 507522017084 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 507522017085 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 507522017086 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 507522017087 PYR/PP interface [polypeptide binding]; other site 507522017088 dimer interface [polypeptide binding]; other site 507522017089 TPP binding site [chemical binding]; other site 507522017090 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 507522017091 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 507522017092 TPP-binding site [chemical binding]; other site 507522017093 dimer interface [polypeptide binding]; other site 507522017094 ilvG operon leader peptide; Provisional; Region: PRK10424 507522017095 putative ATP-dependent protease; Provisional; Region: PRK09862 507522017096 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 507522017097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522017098 Walker A motif; other site 507522017099 ATP binding site [chemical binding]; other site 507522017100 Walker B motif; other site 507522017101 arginine finger; other site 507522017102 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 507522017103 hypothetical protein; Provisional; Region: PRK11027 507522017104 transcriptional regulator HdfR; Provisional; Region: PRK03601 507522017105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017106 LysR substrate binding domain; Region: LysR_substrate; pfam03466 507522017107 glutamate racemase; Provisional; Region: PRK00865 507522017108 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 507522017109 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 507522017110 N-terminal plug; other site 507522017111 ligand-binding site [chemical binding]; other site 507522017112 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 507522017113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522017114 S-adenosylmethionine binding site [chemical binding]; other site 507522017115 hypothetical protein; Provisional; Region: PRK11056 507522017116 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 507522017117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 507522017118 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 507522017119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 507522017120 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 507522017121 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 507522017122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017123 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 507522017124 dimerization interface [polypeptide binding]; other site 507522017125 argininosuccinate lyase; Provisional; Region: PRK04833 507522017126 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 507522017127 active sites [active] 507522017128 tetramer interface [polypeptide binding]; other site 507522017129 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 507522017130 nucleotide binding site [chemical binding]; other site 507522017131 N-acetyl-L-glutamate binding site [chemical binding]; other site 507522017132 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 507522017133 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 507522017134 acetylornithine deacetylase; Provisional; Region: PRK05111 507522017135 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 507522017136 metal binding site [ion binding]; metal-binding site 507522017137 putative dimer interface [polypeptide binding]; other site 507522017138 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 507522017139 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 507522017140 zinc/cadmium-binding protein; Provisional; Region: PRK10306 507522017141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 507522017142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522017143 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 507522017144 active site 507522017145 intersubunit interactions; other site 507522017146 catalytic residue [active] 507522017147 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 507522017148 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 507522017149 dimer interface [polypeptide binding]; other site 507522017150 active site 507522017151 metal binding site [ion binding]; metal-binding site 507522017152 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 507522017153 FAD binding site [chemical binding]; other site 507522017154 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 507522017155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017156 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 507522017157 dimerization interface [polypeptide binding]; other site 507522017158 substrate binding pocket [chemical binding]; other site 507522017159 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 507522017160 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 507522017161 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 507522017162 putative catalytic residues [active] 507522017163 putative nucleotide binding site [chemical binding]; other site 507522017164 putative aspartate binding site [chemical binding]; other site 507522017165 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 507522017166 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 507522017167 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 507522017168 cystathionine gamma-synthase; Provisional; Region: PRK08045 507522017169 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 507522017170 homodimer interface [polypeptide binding]; other site 507522017171 substrate-cofactor binding pocket; other site 507522017172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 507522017173 catalytic residue [active] 507522017174 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 507522017175 dimerization interface [polypeptide binding]; other site 507522017176 DNA binding site [nucleotide binding] 507522017177 corepressor binding sites; other site 507522017178 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 507522017179 primosome assembly protein PriA; Validated; Region: PRK05580 507522017180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 507522017181 ATP binding site [chemical binding]; other site 507522017182 putative Mg++ binding site [ion binding]; other site 507522017183 helicase superfamily c-terminal domain; Region: HELICc; smart00490 507522017184 ATP-binding site [chemical binding]; other site 507522017185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522017186 DNA binding site [nucleotide binding] 507522017187 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 507522017188 domain linker motif; other site 507522017189 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 507522017190 dimerization interface [polypeptide binding]; other site 507522017191 ligand binding site [chemical binding]; other site 507522017192 Sporulation related domain; Region: SPOR; cl10051 507522017193 cell division protein FtsN; Provisional; Region: PRK12757 507522017194 Sporulation related domain; Region: SPOR; cl10051 507522017195 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 507522017196 active site 507522017197 HslU subunit interaction site [polypeptide binding]; other site 507522017198 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 507522017199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522017200 Walker A motif; other site 507522017201 ATP binding site [chemical binding]; other site 507522017202 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 507522017203 Walker B motif; other site 507522017204 arginine finger; other site 507522017205 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 507522017206 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 507522017207 UbiA prenyltransferase family; Region: UbiA; pfam01040 507522017208 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 507522017209 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 507522017210 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 507522017211 active site 507522017212 ADP/pyrophosphate binding site [chemical binding]; other site 507522017213 dimerization interface [polypeptide binding]; other site 507522017214 allosteric effector site; other site 507522017215 fructose-1,6-bisphosphate binding site; other site 507522017216 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 507522017217 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 507522017218 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 507522017219 dimer interface [polypeptide binding]; other site 507522017220 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 507522017221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522017222 active site 507522017223 phosphorylation site [posttranslational modification] 507522017224 intermolecular recognition site; other site 507522017225 dimerization interface [polypeptide binding]; other site 507522017226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 507522017227 DNA binding site [nucleotide binding] 507522017228 two-component sensor protein; Provisional; Region: cpxA; PRK09470 507522017229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 507522017230 dimerization interface [polypeptide binding]; other site 507522017231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522017232 dimer interface [polypeptide binding]; other site 507522017233 phosphorylation site [posttranslational modification] 507522017234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522017235 ATP binding site [chemical binding]; other site 507522017236 Mg2+ binding site [ion binding]; other site 507522017237 G-X-G motif; other site 507522017238 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 507522017239 MOSC domain; Region: MOSC; pfam03473 507522017240 3-alpha domain; Region: 3-alpha; pfam03475 507522017241 superoxide dismutase; Provisional; Region: PRK10925 507522017242 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 507522017243 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 507522017244 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 507522017245 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 507522017246 transcriptional activator RhaR; Provisional; Region: PRK13502 507522017247 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522017248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522017249 transcriptional activator RhaS; Provisional; Region: PRK13503 507522017250 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 507522017251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522017252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 507522017253 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 507522017254 N- and C-terminal domain interface [polypeptide binding]; other site 507522017255 active site 507522017256 putative catalytic site [active] 507522017257 metal binding site [ion binding]; metal-binding site 507522017258 ATP binding site [chemical binding]; other site 507522017259 rhamnulokinase; Provisional; Region: rhaB; PRK10640 507522017260 carbohydrate binding site [chemical binding]; other site 507522017261 L-rhamnose isomerase; Provisional; Region: PRK01076 507522017262 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 507522017263 intersubunit interface [polypeptide binding]; other site 507522017264 active site 507522017265 Zn2+ binding site [ion binding]; other site 507522017266 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 507522017267 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 507522017268 ligand binding site [chemical binding]; other site 507522017269 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 507522017270 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522017271 Walker A/P-loop; other site 507522017272 ATP binding site [chemical binding]; other site 507522017273 Q-loop/lid; other site 507522017274 ABC transporter signature motif; other site 507522017275 Walker B; other site 507522017276 D-loop; other site 507522017277 H-loop/switch region; other site 507522017278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522017279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522017280 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522017281 TM-ABC transporter signature motif; other site 507522017282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522017283 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522017284 TM-ABC transporter signature motif; other site 507522017285 lactaldehyde reductase; Region: lactal_redase; TIGR02638 507522017286 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 507522017287 dimer interface [polypeptide binding]; other site 507522017288 active site 507522017289 metal binding site [ion binding]; metal-binding site 507522017290 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 507522017291 galactoside permease; Reviewed; Region: lacY; PRK09528 507522017292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522017293 putative substrate translocation pore; other site 507522017294 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 507522017295 Melibiase; Region: Melibiase; pfam02065 507522017296 Transcriptional regulators [Transcription]; Region: PurR; COG1609 507522017297 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522017298 DNA binding site [nucleotide binding] 507522017299 domain linker motif; other site 507522017300 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 507522017301 ligand binding site [chemical binding]; other site 507522017302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 507522017303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 507522017304 non-specific DNA binding site [nucleotide binding]; other site 507522017305 salt bridge; other site 507522017306 sequence-specific DNA binding site [nucleotide binding]; other site 507522017307 Cupin domain; Region: Cupin_2; cl17218 507522017308 AzlC protein; Region: AzlC; cl00570 507522017309 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 507522017310 AAA domain; Region: AAA_17; pfam13207 507522017311 AAA domain; Region: AAA_18; pfam13238 507522017312 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 507522017313 active site 507522017314 phosphorylation site [posttranslational modification] 507522017315 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 507522017316 intersubunit interface [polypeptide binding]; other site 507522017317 active site 507522017318 zinc binding site [ion binding]; other site 507522017319 Na+ binding site [ion binding]; other site 507522017320 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 507522017321 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 507522017322 active site 507522017323 P-loop; other site 507522017324 phosphorylation site [posttranslational modification] 507522017325 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 507522017326 dimerization interface [polypeptide binding]; other site 507522017327 allosteric effector site; other site 507522017328 active site 507522017329 ADP/pyrophosphate binding site [chemical binding]; other site 507522017330 fructose-1,6-bisphosphate binding site; other site 507522017331 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 507522017332 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 507522017333 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 507522017334 [4Fe-4S] binding site [ion binding]; other site 507522017335 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 507522017336 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 507522017337 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 507522017338 molybdopterin cofactor binding site; other site 507522017339 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 507522017340 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 507522017341 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 507522017342 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 507522017343 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 507522017344 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 507522017345 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 507522017346 oligomeric interface; other site 507522017347 putative active site [active] 507522017348 homodimer interface [polypeptide binding]; other site 507522017349 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 507522017350 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 507522017351 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 507522017352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522017353 Coenzyme A binding pocket [chemical binding]; other site 507522017354 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 507522017355 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 507522017356 putative active site [active] 507522017357 dimerization interface [polypeptide binding]; other site 507522017358 putative tRNAtyr binding site [nucleotide binding]; other site 507522017359 hypothetical protein; Reviewed; Region: PRK01637 507522017360 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 507522017361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522017362 motif II; other site 507522017363 GTP-binding protein; Provisional; Region: PRK10218 507522017364 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 507522017365 G1 box; other site 507522017366 putative GEF interaction site [polypeptide binding]; other site 507522017367 GTP/Mg2+ binding site [chemical binding]; other site 507522017368 Switch I region; other site 507522017369 G2 box; other site 507522017370 G3 box; other site 507522017371 Switch II region; other site 507522017372 G4 box; other site 507522017373 G5 box; other site 507522017374 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 507522017375 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 507522017376 glutamine synthetase; Provisional; Region: glnA; PRK09469 507522017377 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 507522017378 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 507522017379 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 507522017380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 507522017381 putative active site [active] 507522017382 heme pocket [chemical binding]; other site 507522017383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 507522017384 dimer interface [polypeptide binding]; other site 507522017385 phosphorylation site [posttranslational modification] 507522017386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 507522017387 ATP binding site [chemical binding]; other site 507522017388 Mg2+ binding site [ion binding]; other site 507522017389 G-X-G motif; other site 507522017390 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 507522017391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 507522017392 active site 507522017393 phosphorylation site [posttranslational modification] 507522017394 intermolecular recognition site; other site 507522017395 dimerization interface [polypeptide binding]; other site 507522017396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522017397 Walker A motif; other site 507522017398 ATP binding site [chemical binding]; other site 507522017399 Walker B motif; other site 507522017400 arginine finger; other site 507522017401 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 507522017402 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 507522017403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 507522017404 FeS/SAM binding site; other site 507522017405 HemN C-terminal domain; Region: HemN_C; pfam06969 507522017406 Der GTPase activator; Provisional; Region: PRK05244 507522017407 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 507522017408 G1 box; other site 507522017409 GTP/Mg2+ binding site [chemical binding]; other site 507522017410 Switch I region; other site 507522017411 G2 box; other site 507522017412 G3 box; other site 507522017413 Switch II region; other site 507522017414 G4 box; other site 507522017415 G5 box; other site 507522017416 DNA polymerase I; Provisional; Region: PRK05755 507522017417 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 507522017418 active site 507522017419 metal binding site 1 [ion binding]; metal-binding site 507522017420 putative 5' ssDNA interaction site; other site 507522017421 metal binding site 3; metal-binding site 507522017422 metal binding site 2 [ion binding]; metal-binding site 507522017423 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 507522017424 putative DNA binding site [nucleotide binding]; other site 507522017425 putative metal binding site [ion binding]; other site 507522017426 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 507522017427 active site 507522017428 catalytic site [active] 507522017429 substrate binding site [chemical binding]; other site 507522017430 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 507522017431 active site 507522017432 DNA binding site [nucleotide binding] 507522017433 catalytic site [active] 507522017434 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 507522017435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 507522017436 putative acyl-acceptor binding pocket; other site 507522017437 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 507522017438 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 507522017439 catalytic residues [active] 507522017440 hinge region; other site 507522017441 alpha helical domain; other site 507522017442 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 507522017443 serine/threonine protein kinase; Provisional; Region: PRK11768 507522017444 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 507522017445 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 507522017446 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 507522017447 GTP binding site; other site 507522017448 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 507522017449 Walker A motif; other site 507522017450 Transcriptional regulators [Transcription]; Region: GntR; COG1802 507522017451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 507522017452 DNA-binding site [nucleotide binding]; DNA binding site 507522017453 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 507522017454 putative transporter; Provisional; Region: PRK10504 507522017455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522017456 putative substrate translocation pore; other site 507522017457 transcriptional repressor RbsR; Provisional; Region: PRK10423 507522017458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 507522017459 DNA binding site [nucleotide binding] 507522017460 domain linker motif; other site 507522017461 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 507522017462 dimerization interface [polypeptide binding]; other site 507522017463 ligand binding site [chemical binding]; other site 507522017464 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 507522017465 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 507522017466 substrate binding site [chemical binding]; other site 507522017467 dimer interface [polypeptide binding]; other site 507522017468 ATP binding site [chemical binding]; other site 507522017469 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 507522017470 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 507522017471 ligand binding site [chemical binding]; other site 507522017472 dimerization interface [polypeptide binding]; other site 507522017473 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 507522017474 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 507522017475 TM-ABC transporter signature motif; other site 507522017476 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 507522017477 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 507522017478 Walker A/P-loop; other site 507522017479 ATP binding site [chemical binding]; other site 507522017480 Q-loop/lid; other site 507522017481 ABC transporter signature motif; other site 507522017482 Walker B; other site 507522017483 D-loop; other site 507522017484 H-loop/switch region; other site 507522017485 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 507522017486 D-ribose pyranase; Provisional; Region: PRK11797 507522017487 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 507522017488 potassium uptake protein; Region: kup; TIGR00794 507522017489 regulatory ATPase RavA; Provisional; Region: PRK13531 507522017490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 507522017491 Walker A motif; other site 507522017492 ATP binding site [chemical binding]; other site 507522017493 Walker B motif; other site 507522017494 arginine finger; other site 507522017495 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 507522017496 hypothetical protein; Provisional; Region: yieM; PRK10997 507522017497 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 507522017498 metal ion-dependent adhesion site (MIDAS); other site 507522017499 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 507522017500 dimer interface [polypeptide binding]; other site 507522017501 active site 507522017502 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 507522017503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 507522017504 putative DNA binding site [nucleotide binding]; other site 507522017505 putative Zn2+ binding site [ion binding]; other site 507522017506 AsnC family; Region: AsnC_trans_reg; pfam01037 507522017507 FMN-binding protein MioC; Provisional; Region: PRK09004 507522017508 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 507522017509 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 507522017510 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 507522017511 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 507522017512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 507522017513 S-adenosylmethionine binding site [chemical binding]; other site 507522017514 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 507522017515 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 507522017516 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 507522017517 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 507522017518 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 507522017519 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 507522017520 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 507522017521 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 507522017522 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 507522017523 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 507522017524 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 507522017525 beta subunit interaction interface [polypeptide binding]; other site 507522017526 Walker A motif; other site 507522017527 ATP binding site [chemical binding]; other site 507522017528 Walker B motif; other site 507522017529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 507522017530 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 507522017531 core domain interface [polypeptide binding]; other site 507522017532 delta subunit interface [polypeptide binding]; other site 507522017533 epsilon subunit interface [polypeptide binding]; other site 507522017534 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 507522017535 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 507522017536 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 507522017537 alpha subunit interaction interface [polypeptide binding]; other site 507522017538 Walker A motif; other site 507522017539 ATP binding site [chemical binding]; other site 507522017540 Walker B motif; other site 507522017541 inhibitor binding site; inhibition site 507522017542 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 507522017543 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 507522017544 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 507522017545 gamma subunit interface [polypeptide binding]; other site 507522017546 epsilon subunit interface [polypeptide binding]; other site 507522017547 LBP interface [polypeptide binding]; other site 507522017548 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 507522017549 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 507522017550 Substrate binding site; other site 507522017551 Mg++ binding site; other site 507522017552 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 507522017553 active site 507522017554 substrate binding site [chemical binding]; other site 507522017555 CoA binding site [chemical binding]; other site 507522017556 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 507522017557 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 507522017558 glutaminase active site [active] 507522017559 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 507522017560 dimer interface [polypeptide binding]; other site 507522017561 active site 507522017562 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 507522017563 dimer interface [polypeptide binding]; other site 507522017564 active site 507522017565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 507522017566 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 507522017567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522017568 dimer interface [polypeptide binding]; other site 507522017569 conserved gate region; other site 507522017570 putative PBP binding loops; other site 507522017571 ABC-ATPase subunit interface; other site 507522017572 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 507522017573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 507522017574 dimer interface [polypeptide binding]; other site 507522017575 conserved gate region; other site 507522017576 putative PBP binding loops; other site 507522017577 ABC-ATPase subunit interface; other site 507522017578 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 507522017579 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 507522017580 Walker A/P-loop; other site 507522017581 ATP binding site [chemical binding]; other site 507522017582 Q-loop/lid; other site 507522017583 ABC transporter signature motif; other site 507522017584 Walker B; other site 507522017585 D-loop; other site 507522017586 H-loop/switch region; other site 507522017587 transcriptional regulator PhoU; Provisional; Region: PRK11115 507522017588 PhoU domain; Region: PhoU; pfam01895 507522017589 PhoU domain; Region: PhoU; pfam01895 507522017590 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 507522017591 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 507522017592 trimer interface; other site 507522017593 sugar binding site [chemical binding]; other site 507522017594 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 507522017595 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 507522017596 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 507522017597 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 507522017598 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 507522017599 active site 507522017600 trimer interface [polypeptide binding]; other site 507522017601 allosteric site; other site 507522017602 active site lid [active] 507522017603 hexamer (dimer of trimers) interface [polypeptide binding]; other site 507522017604 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 507522017605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 507522017606 active site 507522017607 motif I; other site 507522017608 motif II; other site 507522017609 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 507522017610 Predicted flavoprotein [General function prediction only]; Region: COG0431 507522017611 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 507522017612 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 507522017613 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 507522017614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 507522017615 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 507522017616 substrate binding pocket [chemical binding]; other site 507522017617 dimerization interface [polypeptide binding]; other site 507522017618 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 507522017619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 507522017620 putative substrate translocation pore; other site 507522017621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 507522017622 Coenzyme A binding pocket [chemical binding]; other site 507522017623 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 507522017624 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 507522017625 trmE is a tRNA modification GTPase; Region: trmE; cd04164 507522017626 G1 box; other site 507522017627 GTP/Mg2+ binding site [chemical binding]; other site 507522017628 Switch I region; other site 507522017629 G2 box; other site 507522017630 Switch II region; other site 507522017631 G3 box; other site 507522017632 G4 box; other site 507522017633 G5 box; other site 507522017634 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 507522017635 membrane protein insertase; Provisional; Region: PRK01318 507522017636 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 507522017637 ribonuclease P; Reviewed; Region: rnpA; PRK01732 507522017638 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399