-- dump date 20111121_012711 -- class Genbank::misc_feature -- table misc_feature_note -- id note 479435000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 479435000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 479435000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435000004 Walker A motif; other site 479435000005 ATP binding site [chemical binding]; other site 479435000006 Walker B motif; other site 479435000007 arginine finger; other site 479435000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 479435000009 DnaA box-binding interface [nucleotide binding]; other site 479435000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 479435000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 479435000012 putative DNA binding surface [nucleotide binding]; other site 479435000013 dimer interface [polypeptide binding]; other site 479435000014 beta-clamp/clamp loader binding surface; other site 479435000015 beta-clamp/translesion DNA polymerase binding surface; other site 479435000016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 479435000018 recombination protein F; Reviewed; Region: recF; PRK00064 479435000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 479435000020 Walker A/P-loop; other site 479435000021 ATP binding site [chemical binding]; other site 479435000022 Q-loop/lid; other site 479435000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000024 ABC transporter signature motif; other site 479435000025 Walker B; other site 479435000026 D-loop; other site 479435000027 H-loop/switch region; other site 479435000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 479435000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 479435000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 479435000031 anchoring element; other site 479435000032 dimer interface [polypeptide binding]; other site 479435000033 ATP binding site [chemical binding]; other site 479435000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 479435000035 active site 479435000036 putative metal-binding site [ion binding]; other site 479435000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 479435000038 DNA gyrase subunit A; Validated; Region: PRK05560 479435000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 479435000040 CAP-like domain; other site 479435000041 Active site [active] 479435000042 primary dimer interface [polypeptide binding]; other site 479435000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 479435000048 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435000049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000052 short chain dehydrogenase; Provisional; Region: PRK06197 479435000053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000054 NAD(P) binding site [chemical binding]; other site 479435000055 active site 479435000056 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479435000057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435000058 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479435000059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000060 NAD(P) binding site [chemical binding]; other site 479435000061 active site 479435000062 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479435000063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000065 FAD binding domain; Region: FAD_binding_4; pfam01565 479435000066 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435000067 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435000068 putative metal binding site [ion binding]; other site 479435000069 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435000070 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435000071 sugar binding site [chemical binding]; other site 479435000072 classical (c) SDRs; Region: SDR_c; cd05233 479435000073 NAD(P) binding site [chemical binding]; other site 479435000074 active site 479435000075 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 479435000076 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 479435000077 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435000078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000079 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435000080 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435000081 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 479435000082 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 479435000083 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435000084 DNA binding site [nucleotide binding] 479435000085 active site 479435000086 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435000087 active site 479435000088 Rhomboid family; Region: Rhomboid; cl11446 479435000089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000090 FAD binding domain; Region: FAD_binding_3; pfam01494 479435000091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000094 DNA binding site [nucleotide binding] 479435000095 domain linker motif; other site 479435000096 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000097 ligand binding site [chemical binding]; other site 479435000098 dimerization interface [polypeptide binding]; other site 479435000099 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 479435000100 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 479435000101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000102 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435000103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000104 dimer interface [polypeptide binding]; other site 479435000105 ABC-ATPase subunit interface; other site 479435000106 putative PBP binding loops; other site 479435000107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000108 dimer interface [polypeptide binding]; other site 479435000109 conserved gate region; other site 479435000110 putative PBP binding loops; other site 479435000111 ABC-ATPase subunit interface; other site 479435000112 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435000113 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 479435000114 active site 479435000115 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 479435000116 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 479435000117 putative substrate binding site [chemical binding]; other site 479435000118 active site 479435000119 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435000120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000121 DNA-binding site [nucleotide binding]; DNA binding site 479435000122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000124 homodimer interface [polypeptide binding]; other site 479435000125 catalytic residue [active] 479435000126 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435000127 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435000128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000129 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435000130 Walker A/P-loop; other site 479435000131 ATP binding site [chemical binding]; other site 479435000132 Q-loop/lid; other site 479435000133 ABC transporter signature motif; other site 479435000134 Walker B; other site 479435000135 D-loop; other site 479435000136 H-loop/switch region; other site 479435000137 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 479435000138 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 479435000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 479435000140 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435000141 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 479435000142 Glutamine amidotransferase class-I; Region: GATase; pfam00117 479435000143 glutamine binding [chemical binding]; other site 479435000144 catalytic triad [active] 479435000145 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435000146 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435000147 active site 479435000148 ATP binding site [chemical binding]; other site 479435000149 substrate binding site [chemical binding]; other site 479435000150 activation loop (A-loop); other site 479435000151 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435000152 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435000153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435000155 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 479435000156 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479435000157 Active site [active] 479435000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435000159 phosphopeptide binding site; other site 479435000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 479435000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435000162 phosphopeptide binding site; other site 479435000163 Predicted transcriptional regulators [Transcription]; Region: COG1378 479435000164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000166 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435000167 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435000168 active site 479435000169 catalytic residues [active] 479435000170 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 479435000171 putative hydrophobic ligand binding site [chemical binding]; other site 479435000172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000174 homodimer interface [polypeptide binding]; other site 479435000175 catalytic residue [active] 479435000176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435000177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000179 dimer interface [polypeptide binding]; other site 479435000180 conserved gate region; other site 479435000181 putative PBP binding loops; other site 479435000182 ABC-ATPase subunit interface; other site 479435000183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000185 dimer interface [polypeptide binding]; other site 479435000186 conserved gate region; other site 479435000187 putative PBP binding loops; other site 479435000188 ABC-ATPase subunit interface; other site 479435000189 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435000190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000191 DNA-binding site [nucleotide binding]; DNA binding site 479435000192 UTRA domain; Region: UTRA; cl01230 479435000193 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 479435000194 active site 479435000195 catalytic residues [active] 479435000196 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435000198 DNA binding residues [nucleotide binding] 479435000199 Endonuclease I; Region: Endonuclease_1; cl01003 479435000200 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 479435000201 putative metal binding site [ion binding]; other site 479435000202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000203 dimerization interface [polypeptide binding]; other site 479435000204 putative DNA binding site [nucleotide binding]; other site 479435000205 putative Zn2+ binding site [ion binding]; other site 479435000206 Cation efflux family; Region: Cation_efflux; cl00316 479435000207 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 479435000208 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435000209 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435000210 FAD binding pocket [chemical binding]; other site 479435000211 FAD binding motif [chemical binding]; other site 479435000212 phosphate binding motif [ion binding]; other site 479435000213 NAD binding pocket [chemical binding]; other site 479435000214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000216 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435000217 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 479435000218 apolar tunnel; other site 479435000219 heme binding site [chemical binding]; other site 479435000220 dimerization interface [polypeptide binding]; other site 479435000221 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 479435000222 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 479435000223 Walker A/P-loop; other site 479435000224 ATP binding site [chemical binding]; other site 479435000225 Q-loop/lid; other site 479435000226 ABC transporter signature motif; other site 479435000227 Walker B; other site 479435000228 D-loop; other site 479435000229 H-loop/switch region; other site 479435000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000231 dimer interface [polypeptide binding]; other site 479435000232 conserved gate region; other site 479435000233 putative PBP binding loops; other site 479435000234 ABC-ATPase subunit interface; other site 479435000235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435000236 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435000237 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 479435000238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435000239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435000240 P-loop; other site 479435000241 Magnesium ion binding site [ion binding]; other site 479435000242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000243 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435000244 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435000245 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 479435000246 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435000247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000250 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435000251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000252 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435000253 nudix motif; other site 479435000254 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435000255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000257 NAD(P) binding site [chemical binding]; other site 479435000258 active site 479435000259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000261 Proline dehydrogenase; Region: Pro_dh; cl03282 479435000262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000263 putative substrate translocation pore; other site 479435000264 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 479435000265 4-coumarate--CoA ligase; Region: PLN02246 479435000266 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435000267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435000268 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479435000269 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 479435000270 active site 479435000271 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 479435000272 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435000273 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435000274 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 479435000275 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 479435000276 carboxyltransferase (CT) interaction site; other site 479435000277 biotinylation site [posttranslational modification]; other site 479435000278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 479435000279 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 479435000280 Probable transposase; Region: OrfB_IS605; pfam01385 479435000281 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 479435000282 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 479435000283 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435000284 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435000285 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435000286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435000287 active site 479435000288 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 479435000289 TIGR03084 family protein; Region: TIGR03084 479435000290 DinB superfamily; Region: DinB_2; cl00986 479435000291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435000292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000293 dimerization interface [polypeptide binding]; other site 479435000294 putative DNA binding site [nucleotide binding]; other site 479435000295 putative Zn2+ binding site [ion binding]; other site 479435000296 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 479435000297 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435000298 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435000299 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435000300 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435000301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000302 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435000303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000304 ABC-ATPase subunit interface; other site 479435000305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000307 dimer interface [polypeptide binding]; other site 479435000308 conserved gate region; other site 479435000309 putative PBP binding loops; other site 479435000310 ABC-ATPase subunit interface; other site 479435000311 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435000312 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435000313 inhibitor site; inhibition site 479435000314 active site 479435000315 dimer interface [polypeptide binding]; other site 479435000316 catalytic residue [active] 479435000317 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435000318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000319 DNA-binding site [nucleotide binding]; DNA binding site 479435000320 FCD domain; Region: FCD; cl11656 479435000321 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435000322 catalytic site [active] 479435000323 Asp-box motif; other site 479435000324 cyclically-permuted mutatrotase family protein; Region: mutarot_permut; TIGR03548 479435000325 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 479435000326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435000327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435000328 hydrophobic ligand binding site; other site 479435000329 Predicted membrane protein [Function unknown]; Region: COG1511 479435000330 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 479435000331 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435000332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000333 Walker A/P-loop; other site 479435000334 ATP binding site [chemical binding]; other site 479435000335 Q-loop/lid; other site 479435000336 ABC transporter signature motif; other site 479435000337 Walker B; other site 479435000338 D-loop; other site 479435000339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000341 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 479435000342 Moco binding site; other site 479435000343 metal coordination site [ion binding]; other site 479435000344 dimerization interface [polypeptide binding]; other site 479435000345 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435000346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435000348 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435000349 active site 479435000350 metal binding site [ion binding]; metal-binding site 479435000351 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 479435000352 active site 479435000353 catalytic residues [active] 479435000354 metal binding site [ion binding]; metal-binding site 479435000355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435000356 active site 479435000357 metal binding site [ion binding]; metal-binding site 479435000358 EcsC protein family; Region: EcsC; pfam12787 479435000359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435000360 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 479435000361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000362 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435000363 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435000364 active site 479435000365 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435000367 DNA binding residues [nucleotide binding] 479435000368 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435000369 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435000370 conserved cys residue [active] 479435000371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435000372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000373 S-adenosylmethionine binding site [chemical binding]; other site 479435000374 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435000375 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 479435000376 putative DNA binding site [nucleotide binding]; other site 479435000377 catalytic residue [active] 479435000378 putative H2TH interface [polypeptide binding]; other site 479435000379 putative catalytic residues [active] 479435000380 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435000381 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435000382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479435000383 active site residue [active] 479435000384 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 479435000385 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435000386 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435000387 active site 479435000388 metal binding site [ion binding]; metal-binding site 479435000389 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 479435000390 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 479435000391 dimer interface [polypeptide binding]; other site 479435000392 catalytic triad [active] 479435000393 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435000394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000395 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435000396 homotrimer interaction site [polypeptide binding]; other site 479435000397 putative active site [active] 479435000398 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435000399 putative hydrophobic ligand binding site [chemical binding]; other site 479435000400 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479435000401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435000402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435000403 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435000404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000405 Walker A/P-loop; other site 479435000406 ATP binding site [chemical binding]; other site 479435000407 Q-loop/lid; other site 479435000408 ABC transporter signature motif; other site 479435000409 Walker B; other site 479435000410 D-loop; other site 479435000411 H-loop/switch region; other site 479435000412 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435000413 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 479435000414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000415 Walker A/P-loop; other site 479435000416 ATP binding site [chemical binding]; other site 479435000417 Q-loop/lid; other site 479435000418 ABC transporter signature motif; other site 479435000419 Walker B; other site 479435000420 D-loop; other site 479435000421 H-loop/switch region; other site 479435000422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000423 putative substrate translocation pore; other site 479435000424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000425 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 479435000426 synthetase active site [active] 479435000427 NTP binding site [chemical binding]; other site 479435000428 metal binding site [ion binding]; metal-binding site 479435000429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435000430 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435000431 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435000432 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 479435000433 ADP-ribose binding site [chemical binding]; other site 479435000434 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 479435000435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435000436 Sodium:solute symporter family; Region: SSF; cl00456 479435000437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000438 S-adenosylmethionine binding site [chemical binding]; other site 479435000439 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 479435000440 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435000441 DNA binding site [nucleotide binding] 479435000442 active site 479435000443 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435000444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000446 Flavin Reductases; Region: FlaRed; cl00801 479435000447 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 479435000448 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435000449 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435000450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435000451 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479435000452 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 479435000453 Walker A/P-loop; other site 479435000454 ATP binding site [chemical binding]; other site 479435000455 Q-loop/lid; other site 479435000456 ABC transporter signature motif; other site 479435000457 Walker B; other site 479435000458 D-loop; other site 479435000459 H-loop/switch region; other site 479435000460 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 479435000461 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 479435000462 active site 479435000463 non-prolyl cis peptide bond; other site 479435000464 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435000465 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435000466 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 479435000467 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435000468 putative active site [active] 479435000469 catalytic site [active] 479435000470 putative metal binding site [ion binding]; other site 479435000471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435000472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 479435000473 SEC-C motif; Region: SEC-C; cl12132 479435000474 Amidinotransferase; Region: Amidinotransf; cl12043 479435000475 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 479435000476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435000477 active site 479435000478 Cupin domain; Region: Cupin_2; cl09118 479435000479 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 479435000480 Protein of unknown function DUF111; Region: DUF111; pfam01969 479435000481 AIR carboxylase; Region: AIRC; cl00310 479435000482 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 479435000483 active site 479435000484 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479435000485 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435000486 seryl-tRNA synthetase; Provisional; Region: PRK05431 479435000487 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 479435000488 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 479435000489 dimer interface [polypeptide binding]; other site 479435000490 active site 479435000491 motif 1; other site 479435000492 motif 2; other site 479435000493 motif 3; other site 479435000494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435000495 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435000496 active site 479435000497 motif I; other site 479435000498 motif II; other site 479435000499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435000500 Transcription factor WhiB; Region: Whib; pfam02467 479435000501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435000502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435000503 active site 479435000504 motif I; other site 479435000505 motif II; other site 479435000506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435000507 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 479435000508 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435000509 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435000510 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435000511 Walker A/P-loop; other site 479435000512 ATP binding site [chemical binding]; other site 479435000513 Q-loop/lid; other site 479435000514 ABC transporter signature motif; other site 479435000515 Walker B; other site 479435000516 D-loop; other site 479435000517 H-loop/switch region; other site 479435000518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000520 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 479435000521 putative dimer interface [polypeptide binding]; other site 479435000522 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 479435000523 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 479435000524 NAD(P) binding site [chemical binding]; other site 479435000525 Phosphotransferase enzyme family; Region: APH; pfam01636 479435000526 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435000527 active site 479435000528 substrate binding site [chemical binding]; other site 479435000529 ATP binding site [chemical binding]; other site 479435000530 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 479435000531 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 479435000532 GTP binding site [chemical binding]; other site 479435000533 Predicted amidohydrolase [General function prediction only]; Region: COG0388 479435000534 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 479435000535 putative active site [active] 479435000536 catalytic triad [active] 479435000537 putative dimer interface [polypeptide binding]; other site 479435000538 hypothetical protein; Provisional; Region: PRK07908 479435000539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000541 homodimer interface [polypeptide binding]; other site 479435000542 catalytic residue [active] 479435000543 Cupin superfamily protein; Region: Cupin_4; pfam08007 479435000544 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 479435000545 putative dimer interface [polypeptide binding]; other site 479435000546 putative [2Fe-2S] cluster binding site [ion binding]; other site 479435000547 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435000548 putative trimer interface [polypeptide binding]; other site 479435000549 putative CoA binding site [chemical binding]; other site 479435000550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000551 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435000552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435000553 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435000554 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435000555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000556 NAD(P) binding site [chemical binding]; other site 479435000557 active site 479435000558 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 479435000559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000561 dimerization interface [polypeptide binding]; other site 479435000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435000563 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 479435000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000565 S-adenosylmethionine binding site [chemical binding]; other site 479435000566 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 479435000567 ligand binding site [chemical binding]; other site 479435000568 dimer interface [polypeptide binding]; other site 479435000569 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435000570 DNA binding residues [nucleotide binding] 479435000571 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000573 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435000574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000576 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000577 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 479435000578 active site 479435000579 catalytic residues [active] 479435000580 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 479435000581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000583 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000584 Phosphotransferase enzyme family; Region: APH; pfam01636 479435000585 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435000586 FAD binding domain; Region: FAD_binding_4; pfam01565 479435000587 Berberine and berberine like; Region: BBE; pfam08031 479435000588 Bacterial SH3 domain; Region: SH3_3; cl02551 479435000589 YCII-related domain; Region: YCII; cl00999 479435000590 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000592 putative substrate translocation pore; other site 479435000593 YCII-related domain; Region: YCII; cl00999 479435000594 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435000595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000597 NAD(P) binding site [chemical binding]; other site 479435000598 active site 479435000599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435000600 active site 479435000601 catalytic tetrad [active] 479435000602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000604 DNA binding site [nucleotide binding] 479435000605 domain linker motif; other site 479435000606 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000607 dimerization interface [polypeptide binding]; other site 479435000608 ligand binding site [chemical binding]; other site 479435000609 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435000610 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 479435000611 Walker A/P-loop; other site 479435000612 ATP binding site [chemical binding]; other site 479435000613 Q-loop/lid; other site 479435000614 ABC transporter signature motif; other site 479435000615 Walker B; other site 479435000616 D-loop; other site 479435000617 H-loop/switch region; other site 479435000618 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435000619 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435000620 TM-ABC transporter signature motif; other site 479435000621 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435000622 TM-ABC transporter signature motif; other site 479435000623 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 479435000624 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 479435000625 ligand binding site [chemical binding]; other site 479435000626 Domain of unknown function (DUF718); Region: DUF718; cl01281 479435000627 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 479435000628 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 479435000629 short chain dehydrogenase; Validated; Region: PRK08324 479435000630 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 479435000631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000632 NAD(P) binding site [chemical binding]; other site 479435000633 active site 479435000634 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cd00578 479435000635 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 479435000636 hexamer (dimer of trimers) interface [polypeptide binding]; other site 479435000637 substrate binding site [chemical binding]; other site 479435000638 trimer interface [polypeptide binding]; other site 479435000639 Mn binding site [ion binding]; other site 479435000640 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 479435000641 N- and C-terminal domain interface [polypeptide binding]; other site 479435000642 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 479435000643 active site 479435000644 catalytic site [active] 479435000645 metal binding site [ion binding]; metal-binding site 479435000646 ATP binding site [chemical binding]; other site 479435000647 carbohydrate binding site [chemical binding]; other site 479435000648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000649 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435000650 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 479435000651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435000653 active site 479435000654 phosphorylation site [posttranslational modification] 479435000655 intermolecular recognition site; other site 479435000656 dimerization interface [polypeptide binding]; other site 479435000657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435000658 DNA binding site [nucleotide binding] 479435000659 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 479435000660 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 479435000661 dimerization interface [polypeptide binding]; other site 479435000662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435000663 dimer interface [polypeptide binding]; other site 479435000664 phosphorylation site [posttranslational modification] 479435000665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435000666 ATP binding site [chemical binding]; other site 479435000667 Mg2+ binding site [ion binding]; other site 479435000668 G-X-G motif; other site 479435000669 threonine dehydratase; Validated; Region: PRK08639 479435000670 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435000671 tetramer interface [polypeptide binding]; other site 479435000672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000673 catalytic residue [active] 479435000674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435000675 HIRAN domain; Region: HIRAN; cl07418 479435000676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435000677 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 479435000678 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435000679 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479435000680 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000681 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435000682 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 479435000683 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 479435000684 active site 479435000685 substrate-binding site [chemical binding]; other site 479435000686 metal-binding site [ion binding] 479435000687 GTP binding site [chemical binding]; other site 479435000688 YCII-related domain; Region: YCII; cl00999 479435000689 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 479435000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000691 S-adenosylmethionine binding site [chemical binding]; other site 479435000692 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 479435000693 active site 479435000694 8-oxo-dGMP binding site [chemical binding]; other site 479435000695 nudix motif; other site 479435000696 metal binding site [ion binding]; metal-binding site 479435000697 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 479435000698 active site 479435000699 catalytic triad [active] 479435000700 dimer interface [polypeptide binding]; other site 479435000701 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 479435000702 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000703 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435000704 Protein of unknown function DUF72; Region: DUF72; cl00777 479435000705 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435000706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000707 classical (c) SDRs; Region: SDR_c; cd05233 479435000708 NAD(P) binding site [chemical binding]; other site 479435000709 active site 479435000710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435000711 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435000712 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479435000713 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435000715 binding surface 479435000716 TPR motif; other site 479435000717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435000718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435000719 active site 479435000720 catalytic tetrad [active] 479435000721 PhoD-like phosphatase; Region: PhoD; pfam09423 479435000722 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435000723 putative active site [active] 479435000724 putative metal binding site [ion binding]; other site 479435000725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435000726 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435000727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435000728 Coenzyme A binding pocket [chemical binding]; other site 479435000729 GAF domain; Region: GAF; cl00853 479435000730 PAS domain S-box; Region: sensory_box; TIGR00229 479435000731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435000732 putative active site [active] 479435000733 heme pocket [chemical binding]; other site 479435000734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435000735 metal binding site [ion binding]; metal-binding site 479435000736 active site 479435000737 I-site; other site 479435000738 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435000739 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435000740 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 479435000741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435000742 catalytic residue [active] 479435000743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435000744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000745 Cupin domain; Region: Cupin_2; cl09118 479435000746 Uncharacterized conserved protein [Function unknown]; Region: COG2966 479435000747 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 479435000748 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 479435000749 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435000750 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 479435000751 active site 479435000752 TDP-binding site; other site 479435000753 acceptor substrate-binding pocket; other site 479435000754 homodimer interface [polypeptide binding]; other site 479435000755 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 479435000756 Lumazine binding domain; Region: Lum_binding; pfam00677 479435000757 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 479435000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000759 S-adenosylmethionine binding site [chemical binding]; other site 479435000760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435000761 ligand binding site [chemical binding]; other site 479435000762 flexible hinge region; other site 479435000763 cyclase homology domain; Region: CHD; cd07302 479435000764 nucleotidyl binding site; other site 479435000765 metal binding site [ion binding]; metal-binding site 479435000766 dimer interface [polypeptide binding]; other site 479435000767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435000770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435000771 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 479435000772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435000773 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 479435000774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000776 DNA binding site [nucleotide binding] 479435000777 domain linker motif; other site 479435000778 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000779 dimerization interface [polypeptide binding]; other site 479435000780 ligand binding site [chemical binding]; other site 479435000781 naphthoate synthase; Validated; Region: PRK08321 479435000782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435000783 substrate binding site [chemical binding]; other site 479435000784 oxyanion hole (OAH) forming residues; other site 479435000785 trimer interface [polypeptide binding]; other site 479435000786 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435000787 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 479435000788 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479435000789 nucleoside/Zn binding site; other site 479435000790 dimer interface [polypeptide binding]; other site 479435000791 catalytic motif [active] 479435000792 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479435000793 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435000794 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 479435000795 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435000796 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435000797 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 479435000798 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435000799 metal binding site [ion binding]; metal-binding site 479435000800 active site 479435000801 I-site; other site 479435000802 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435000805 DNA binding residues [nucleotide binding] 479435000806 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435000808 DNA binding residues [nucleotide binding] 479435000809 DinB superfamily; Region: DinB_2; cl00986 479435000810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000811 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435000812 hypothetical protein; Provisional; Region: PRK08317 479435000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435000814 S-adenosylmethionine binding site [chemical binding]; other site 479435000815 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 479435000816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000817 putative substrate translocation pore; other site 479435000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000819 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435000820 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000821 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000822 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435000823 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000824 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435000825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435000826 Histidine kinase; Region: HisKA_3; pfam07730 479435000827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435000828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435000829 active site 479435000830 phosphorylation site [posttranslational modification] 479435000831 intermolecular recognition site; other site 479435000832 dimerization interface [polypeptide binding]; other site 479435000833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435000834 DNA binding residues [nucleotide binding] 479435000835 dimerization interface [polypeptide binding]; other site 479435000836 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435000837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435000838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000839 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 479435000840 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 479435000841 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 479435000842 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 479435000843 RNA binding site [nucleotide binding]; other site 479435000844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435000845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000846 putative substrate translocation pore; other site 479435000847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000849 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000850 dimerization interface [polypeptide binding]; other site 479435000851 ligand binding site [chemical binding]; other site 479435000852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435000853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000854 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435000855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000856 dimer interface [polypeptide binding]; other site 479435000857 conserved gate region; other site 479435000858 putative PBP binding loops; other site 479435000859 ABC-ATPase subunit interface; other site 479435000860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435000862 dimer interface [polypeptide binding]; other site 479435000863 conserved gate region; other site 479435000864 putative PBP binding loops; other site 479435000865 ABC-ATPase subunit interface; other site 479435000866 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435000867 putative catalytic site [active] 479435000868 putative phosphate binding site [ion binding]; other site 479435000869 putative metal binding site [ion binding]; other site 479435000870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435000871 Predicted ATPase [General function prediction only]; Region: COG3899 479435000872 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479435000873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435000874 DNA binding residues [nucleotide binding] 479435000875 dimerization interface [polypeptide binding]; other site 479435000876 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435000877 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000878 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 479435000879 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435000880 homodimer interface [polypeptide binding]; other site 479435000881 active site 479435000882 TDP-binding site; other site 479435000883 acceptor substrate-binding pocket; other site 479435000884 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435000885 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435000886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000887 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435000888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435000889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435000890 classical (c) SDRs; Region: SDR_c; cd05233 479435000891 NAD(P) binding site [chemical binding]; other site 479435000892 active site 479435000893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000894 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435000895 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 479435000896 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435000897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435000898 motif II; other site 479435000899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000900 DNA-binding site [nucleotide binding]; DNA binding site 479435000901 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 479435000902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435000903 DNA translocase FtsK; Provisional; Region: PRK10263 479435000904 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435000905 nucleotide binding site [chemical binding]; other site 479435000906 polymerase nucleotide-binding site; other site 479435000907 primase nucleotide-binding site [nucleotide binding]; other site 479435000908 DNA-binding residues [nucleotide binding]; DNA binding site 479435000909 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 479435000910 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435000911 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 479435000912 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 479435000913 Phage integrase family; Region: Phage_integrase; pfam00589 479435000914 Int/Topo IB signature motif; other site 479435000915 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435000916 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 479435000917 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 479435000918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435000919 SET domain; Region: SET; cl02566 479435000920 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000921 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479435000922 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 479435000923 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 479435000924 homodimer interface [polypeptide binding]; other site 479435000925 NAD binding pocket [chemical binding]; other site 479435000926 ATP binding pocket [chemical binding]; other site 479435000927 Mg binding site [ion binding]; other site 479435000928 active-site loop [active] 479435000929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435000930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435000931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435000932 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435000933 active site 479435000934 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435000935 hydrophobic ligand binding site; other site 479435000936 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435000937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435000938 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435000939 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 479435000940 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 479435000941 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 479435000942 substrate binding site [chemical binding]; other site 479435000943 tetramer interface [polypeptide binding]; other site 479435000944 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 479435000945 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 479435000946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435000947 Walker A motif; other site 479435000948 ATP binding site [chemical binding]; other site 479435000949 Walker B motif; other site 479435000950 arginine finger; other site 479435000951 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 479435000952 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 479435000953 recombination protein RecR; Reviewed; Region: recR; PRK00076 479435000954 RecR protein; Region: RecR; pfam02132 479435000955 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 479435000956 putative active site [active] 479435000957 putative metal-binding site [ion binding]; other site 479435000958 tetramer interface [polypeptide binding]; other site 479435000959 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435000960 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435000961 metal binding site 2 [ion binding]; metal-binding site 479435000962 putative DNA binding helix; other site 479435000963 metal binding site 1 [ion binding]; metal-binding site 479435000964 dimer interface [polypeptide binding]; other site 479435000965 structural Zn2+ binding site [ion binding]; other site 479435000966 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 479435000967 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 479435000968 tetramer interface [polypeptide binding]; other site 479435000969 heme binding pocket [chemical binding]; other site 479435000970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000972 MFS transport protein AraJ; Provisional; Region: PRK10091 479435000973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000974 putative substrate translocation pore; other site 479435000975 DNA polymerase IV; Validated; Region: PRK03858 479435000976 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435000977 active site 479435000978 DNA binding site [nucleotide binding] 479435000979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435000980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435000981 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435000982 DNA binding residues [nucleotide binding] 479435000983 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435000984 putative hydrophobic ligand binding site [chemical binding]; other site 479435000985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000986 dimerization interface [polypeptide binding]; other site 479435000987 putative DNA binding site [nucleotide binding]; other site 479435000988 putative Zn2+ binding site [ion binding]; other site 479435000989 aspartate kinase; Reviewed; Region: PRK06635 479435000990 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 479435000991 putative nucleotide binding site [chemical binding]; other site 479435000992 putative catalytic residues [active] 479435000993 putative Mg ion binding site [ion binding]; other site 479435000994 putative aspartate binding site [chemical binding]; other site 479435000995 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 479435000996 putative allosteric regulatory site; other site 479435000997 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 479435000998 putative allosteric regulatory residue; other site 479435000999 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 479435001000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001001 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 479435001002 Predicted transcriptional regulators [Transcription]; Region: COG1378 479435001003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001005 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 479435001006 cleavage site 479435001007 active site 479435001008 substrate binding sites [chemical binding]; other site 479435001009 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 479435001010 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 479435001011 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 479435001012 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435001013 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435001014 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435001015 nudix motif; other site 479435001016 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435001017 short chain dehydrogenase; Provisional; Region: PRK08219 479435001018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001019 NAD(P) binding site [chemical binding]; other site 479435001020 active site 479435001021 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435001022 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 479435001023 putative active site [active] 479435001024 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435001025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435001026 active site 479435001027 catalytic tetrad [active] 479435001028 isoform II; Region: PAF-AH_p_II; pfam03403 479435001029 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435001030 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435001031 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 479435001032 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 479435001033 putative ligand binding site [chemical binding]; other site 479435001034 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 479435001035 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 479435001036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435001037 putative active site [active] 479435001038 putative metal binding site [ion binding]; other site 479435001039 GatB domain; Region: GatB_Yqey; cl11497 479435001040 Transglycosylase; Region: Transgly; cl07896 479435001041 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 479435001042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435001043 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435001044 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 479435001045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435001046 Walker A motif; other site 479435001047 ATP binding site [chemical binding]; other site 479435001048 Walker B motif; other site 479435001049 arginine finger; other site 479435001050 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479435001051 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435001052 Metal binding site [ion binding]; metal-binding site 479435001053 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435001054 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479435001055 DTAP/Switch II; other site 479435001056 Switch I; other site 479435001057 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 479435001058 homotrimer interaction site [polypeptide binding]; other site 479435001059 putative active site [active] 479435001060 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435001061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435001062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435001063 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435001064 ligand binding site [chemical binding]; other site 479435001065 flexible hinge region; other site 479435001066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001067 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 479435001068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435001069 minor groove reading motif; other site 479435001070 helix-hairpin-helix signature motif; other site 479435001071 substrate binding pocket [chemical binding]; other site 479435001072 active site 479435001073 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 479435001074 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 479435001075 catalytic residues [active] 479435001076 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 479435001077 putative active site [active] 479435001078 putative CoA binding site [chemical binding]; other site 479435001079 nudix motif; other site 479435001080 metal binding site [ion binding]; metal-binding site 479435001081 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435001082 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435001083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435001085 DNA binding residues [nucleotide binding] 479435001086 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435001087 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 479435001088 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 479435001089 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 479435001090 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 479435001091 transmembrane helices; other site 479435001092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001094 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001095 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435001096 Walker A/P-loop; other site 479435001097 ATP binding site [chemical binding]; other site 479435001098 Q-loop/lid; other site 479435001099 ABC transporter signature motif; other site 479435001100 Walker B; other site 479435001101 D-loop; other site 479435001102 H-loop/switch region; other site 479435001103 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435001104 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435001105 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 479435001106 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 479435001107 putative dimer interface [polypeptide binding]; other site 479435001108 N-terminal domain interface [polypeptide binding]; other site 479435001109 putative substrate binding pocket (H-site) [chemical binding]; other site 479435001110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435001111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435001112 DNA-binding site [nucleotide binding]; DNA binding site 479435001113 UTRA domain; Region: UTRA; cl01230 479435001114 acetyl-CoA synthetase; Provisional; Region: PRK00174 479435001115 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 479435001116 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435001117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001119 NAD(P) binding site [chemical binding]; other site 479435001120 active site 479435001121 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001124 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435001125 sugar binding site [chemical binding]; other site 479435001126 Domain of unknown function DUF11; Region: DUF11; cl15273 479435001127 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435001128 Sodium:solute symporter family; Region: SSF; cl00456 479435001129 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479435001130 Protein of unknown function, DUF485; Region: DUF485; cl01231 479435001131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001132 S-adenosylmethionine binding site [chemical binding]; other site 479435001133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001134 active site 479435001135 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435001136 NAD(P) binding site [chemical binding]; other site 479435001137 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 479435001138 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 479435001139 NAD(P) binding site [chemical binding]; other site 479435001140 homodimer interface [polypeptide binding]; other site 479435001141 substrate binding site [chemical binding]; other site 479435001142 active site 479435001143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001144 S-adenosylmethionine binding site [chemical binding]; other site 479435001145 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 479435001146 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 479435001147 inhibitor-cofactor binding pocket; inhibition site 479435001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001149 catalytic residue [active] 479435001150 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 479435001151 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 479435001152 NAD(P) binding site [chemical binding]; other site 479435001153 homodimer interface [polypeptide binding]; other site 479435001154 substrate binding site [chemical binding]; other site 479435001155 active site 479435001156 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435001157 putative active site [active] 479435001158 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 479435001159 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435001160 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435001161 Ligand binding site [chemical binding]; other site 479435001162 Putative Catalytic site [active] 479435001163 DXD motif; other site 479435001164 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 479435001165 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 479435001166 inhibitor-cofactor binding pocket; inhibition site 479435001167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001168 catalytic residue [active] 479435001169 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 479435001170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435001171 active site 479435001172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435001173 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435001174 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435001175 Ligand binding site [chemical binding]; other site 479435001176 Putative Catalytic site [active] 479435001177 DXD motif; other site 479435001178 GtrA-like protein; Region: GtrA; cl00971 479435001179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435001180 pseudaminic acid synthase; Region: PseI; TIGR03586 479435001181 NeuB family; Region: NeuB; cl00496 479435001182 SAF domain; Region: SAF; cl00555 479435001183 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 479435001184 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 479435001185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001186 S-adenosylmethionine binding site [chemical binding]; other site 479435001187 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435001188 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435001189 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435001190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001191 NAD(P) binding site [chemical binding]; other site 479435001192 active site 479435001193 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435001194 FAD binding domain; Region: FAD_binding_4; pfam01565 479435001195 Berberine and berberine like; Region: BBE; pfam08031 479435001196 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001198 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001199 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435001200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435001202 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 479435001203 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435001204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001205 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479435001206 Ligand binding site [chemical binding]; other site 479435001207 Putative Catalytic site [active] 479435001208 DXD motif; other site 479435001209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001210 S-adenosylmethionine binding site [chemical binding]; other site 479435001211 potential frameshift: common BLAST hit: gi|241196800|ref|YP_002970355.1| dTDP-4-dehydrorhamnose 3,5-epimerase 479435001212 Cupin domain; Region: Cupin_2; cl09118 479435001213 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 479435001214 NADP binding site [chemical binding]; other site 479435001215 active site 479435001216 putative substrate binding site [chemical binding]; other site 479435001217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001219 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435001221 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435001222 FtsX-like permease family; Region: FtsX; pfam02687 479435001223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435001224 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435001225 Walker A/P-loop; other site 479435001226 ATP binding site [chemical binding]; other site 479435001227 Q-loop/lid; other site 479435001228 ABC transporter signature motif; other site 479435001229 Walker B; other site 479435001230 D-loop; other site 479435001231 H-loop/switch region; other site 479435001232 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435001233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435001234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001235 active site 479435001236 phosphorylation site [posttranslational modification] 479435001237 intermolecular recognition site; other site 479435001238 dimerization interface [polypeptide binding]; other site 479435001239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435001240 DNA binding site [nucleotide binding] 479435001241 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435001242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435001243 dimer interface [polypeptide binding]; other site 479435001244 phosphorylation site [posttranslational modification] 479435001245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001246 ATP binding site [chemical binding]; other site 479435001247 Mg2+ binding site [ion binding]; other site 479435001248 G-X-G motif; other site 479435001249 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435001250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435001253 arginine-tRNA ligase; Region: PLN02286 479435001254 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 479435001255 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 479435001256 active site 479435001257 HIGH motif; other site 479435001258 KMSK motif region; other site 479435001259 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 479435001260 tRNA binding surface [nucleotide binding]; other site 479435001261 anticodon binding site; other site 479435001262 putative glycosyl transferase; Provisional; Region: PRK10073 479435001263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435001264 active site 479435001265 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 479435001266 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435001267 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479435001268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435001269 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435001270 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435001271 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 479435001272 putative active site [active] 479435001273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001275 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 479435001276 putative deacylase active site [active] 479435001277 Cellulose binding domain; Region: CBM_2; cl02709 479435001278 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435001279 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 479435001280 active site 479435001281 Glyco_18 domain; Region: Glyco_18; smart00636 479435001282 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 479435001283 active site 479435001284 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 479435001285 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 479435001286 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 479435001287 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 479435001288 ATP binding site [chemical binding]; other site 479435001289 Walker A motif; other site 479435001290 hexamer interface [polypeptide binding]; other site 479435001291 Walker B motif; other site 479435001292 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 479435001293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001295 active site 479435001296 phosphorylation site [posttranslational modification] 479435001297 intermolecular recognition site; other site 479435001298 dimerization interface [polypeptide binding]; other site 479435001299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001300 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 479435001301 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479435001302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001303 Walker A/P-loop; other site 479435001304 ATP binding site [chemical binding]; other site 479435001305 Q-loop/lid; other site 479435001306 ABC transporter signature motif; other site 479435001307 Walker B; other site 479435001308 D-loop; other site 479435001309 H-loop/switch region; other site 479435001310 TOBE domain; Region: TOBE_2; cl01440 479435001311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435001312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001313 dimer interface [polypeptide binding]; other site 479435001314 conserved gate region; other site 479435001315 putative PBP binding loops; other site 479435001316 ABC-ATPase subunit interface; other site 479435001317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001318 dimer interface [polypeptide binding]; other site 479435001319 conserved gate region; other site 479435001320 putative PBP binding loops; other site 479435001321 ABC-ATPase subunit interface; other site 479435001322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435001323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435001324 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 479435001325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435001326 ATP binding site [chemical binding]; other site 479435001327 putative Mg++ binding site [ion binding]; other site 479435001328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435001329 nucleotide binding region [chemical binding]; other site 479435001330 ATP-binding site [chemical binding]; other site 479435001331 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 479435001332 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435001333 anti sigma factor interaction site; other site 479435001334 regulatory phosphorylation site [posttranslational modification]; other site 479435001335 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 479435001336 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 479435001337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001338 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 479435001339 Walker A/P-loop; other site 479435001340 ATP binding site [chemical binding]; other site 479435001341 Q-loop/lid; other site 479435001342 ABC transporter signature motif; other site 479435001343 Walker B; other site 479435001344 D-loop; other site 479435001345 H-loop/switch region; other site 479435001346 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435001347 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 479435001348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001349 S-adenosylmethionine binding site [chemical binding]; other site 479435001350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435001351 metal binding site [ion binding]; metal-binding site 479435001352 active site 479435001353 I-site; other site 479435001354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435001355 metal binding site [ion binding]; metal-binding site 479435001356 active site 479435001357 I-site; other site 479435001358 Cytochrome P450; Region: p450; cl12078 479435001359 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 479435001360 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 479435001361 active site 479435001362 interdomain interaction site; other site 479435001363 putative metal-binding site [ion binding]; other site 479435001364 nucleotide binding site [chemical binding]; other site 479435001365 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 479435001366 domain I; other site 479435001367 DNA binding groove [nucleotide binding] 479435001368 phosphate binding site [ion binding]; other site 479435001369 domain II; other site 479435001370 domain III; other site 479435001371 nucleotide binding site [chemical binding]; other site 479435001372 catalytic site [active] 479435001373 domain IV; other site 479435001374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435001375 metal binding site 2 [ion binding]; metal-binding site 479435001376 putative DNA binding helix; other site 479435001377 metal binding site 1 [ion binding]; metal-binding site 479435001378 dimer interface [polypeptide binding]; other site 479435001379 structural Zn2+ binding site [ion binding]; other site 479435001380 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435001381 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 479435001382 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 479435001383 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 479435001384 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435001385 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435001386 NAD(P) binding site [chemical binding]; other site 479435001387 BioY family; Region: BioY; cl00560 479435001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001389 putative substrate translocation pore; other site 479435001390 thymidylate kinase; Validated; Region: tmk; PRK00698 479435001391 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 479435001392 TMP-binding site; other site 479435001393 ATP-binding site [chemical binding]; other site 479435001394 DNA polymerase III subunit delta'; Validated; Region: PRK07940 479435001395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001396 PSP1 C-terminal conserved region; Region: PSP1; cl00770 479435001397 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435001398 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435001399 enterobactin exporter EntS; Provisional; Region: PRK10489 479435001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001401 putative substrate translocation pore; other site 479435001402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435001403 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 479435001404 NAD(P) binding site [chemical binding]; other site 479435001405 catalytic residues [active] 479435001406 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435001407 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435001408 intersubunit interface [polypeptide binding]; other site 479435001409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435001410 ABC-ATPase subunit interface; other site 479435001411 dimer interface [polypeptide binding]; other site 479435001412 putative PBP binding regions; other site 479435001413 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 479435001414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435001415 ABC-ATPase subunit interface; other site 479435001416 dimer interface [polypeptide binding]; other site 479435001417 putative PBP binding regions; other site 479435001418 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435001419 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435001420 Walker A/P-loop; other site 479435001421 ATP binding site [chemical binding]; other site 479435001422 Q-loop/lid; other site 479435001423 ABC transporter signature motif; other site 479435001424 Walker B; other site 479435001425 D-loop; other site 479435001426 H-loop/switch region; other site 479435001427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435001428 DNA-binding site [nucleotide binding]; DNA binding site 479435001429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435001430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001431 homodimer interface [polypeptide binding]; other site 479435001432 catalytic residue [active] 479435001433 hypothetical protein; Provisional; Region: PRK08317 479435001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001435 S-adenosylmethionine binding site [chemical binding]; other site 479435001436 Uncharacterized conserved protein [Function unknown]; Region: COG3025 479435001437 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 479435001438 putative active site; other site 479435001439 putative metal binding residues [ion binding]; other site 479435001440 signature motif; other site 479435001441 putative triphosphate binding site [ion binding]; other site 479435001442 CHAD domain; Region: CHAD; cl10506 479435001443 Cupin domain; Region: Cupin_2; cl09118 479435001444 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001446 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479435001447 Sodium:solute symporter family; Region: SSF; cl00456 479435001448 Protein of unknown function, DUF485; Region: DUF485; cl01231 479435001449 Sodium:solute symporter family; Region: SSF; cl00456 479435001450 Sodium:solute symporter family; Region: SSF; cl00456 479435001451 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 479435001452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001453 active site 479435001454 phosphorylation site [posttranslational modification] 479435001455 intermolecular recognition site; other site 479435001456 dimerization interface [polypeptide binding]; other site 479435001457 LytTr DNA-binding domain; Region: LytTR; cl04498 479435001458 GAF domain; Region: GAF; cl00853 479435001459 Histidine kinase; Region: His_kinase; pfam06580 479435001460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001461 ATP binding site [chemical binding]; other site 479435001462 Mg2+ binding site [ion binding]; other site 479435001463 G-X-G motif; other site 479435001464 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435001465 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435001466 active site 479435001467 metal binding site [ion binding]; metal-binding site 479435001468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435001469 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435001470 active site 479435001471 ATP binding site [chemical binding]; other site 479435001472 substrate binding site [chemical binding]; other site 479435001473 activation loop (A-loop); other site 479435001474 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 479435001475 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 479435001476 active site 479435001477 metal binding site [ion binding]; metal-binding site 479435001478 dimer interface [polypeptide binding]; other site 479435001479 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 479435001480 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 479435001481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001482 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 479435001483 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 479435001484 Predicted transcriptional regulators [Transcription]; Region: COG1378 479435001485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435001486 DNA binding residues [nucleotide binding] 479435001487 dimerization interface [polypeptide binding]; other site 479435001488 amidophosphoribosyltransferase; Provisional; Region: PRK07847 479435001489 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 479435001490 active site 479435001491 tetramer interface [polypeptide binding]; other site 479435001492 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435001493 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 479435001494 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 479435001495 dimerization interface [polypeptide binding]; other site 479435001496 putative ATP binding site [chemical binding]; other site 479435001497 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 479435001498 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001500 Walker A/P-loop; other site 479435001501 ATP binding site [chemical binding]; other site 479435001502 Q-loop/lid; other site 479435001503 ABC transporter signature motif; other site 479435001504 Walker B; other site 479435001505 D-loop; other site 479435001506 H-loop/switch region; other site 479435001507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435001508 Histidine kinase; Region: HisKA_3; pfam07730 479435001509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001511 active site 479435001512 phosphorylation site [posttranslational modification] 479435001513 intermolecular recognition site; other site 479435001514 dimerization interface [polypeptide binding]; other site 479435001515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435001516 DNA binding residues [nucleotide binding] 479435001517 dimerization interface [polypeptide binding]; other site 479435001518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435001519 NlpC/P60 family; Region: NLPC_P60; cl11438 479435001520 serine/threonine dehydratase; Validated; Region: PRK07048 479435001521 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435001522 tetramer interface [polypeptide binding]; other site 479435001523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001524 catalytic residue [active] 479435001525 YCII-related domain; Region: YCII; cl00999 479435001526 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 479435001527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001528 Coenzyme A binding pocket [chemical binding]; other site 479435001529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001530 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435001531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435001533 putative substrate translocation pore; other site 479435001534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001537 translocation protein TolB; Provisional; Region: tolB; PRK04922 479435001538 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 479435001539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435001541 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435001542 catalytic core [active] 479435001543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001544 P-loop motif; other site 479435001545 ATP binding site [chemical binding]; other site 479435001546 Chloramphenicol (Cm) binding site [chemical binding]; other site 479435001547 catalytic residue [active] 479435001548 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 479435001549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001550 S-adenosylmethionine binding site [chemical binding]; other site 479435001551 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 479435001552 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 479435001553 Ligand binding site [chemical binding]; other site 479435001554 Putative Catalytic site [active] 479435001555 DXD motif; other site 479435001556 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 479435001557 N- and C-terminal domain interface [polypeptide binding]; other site 479435001558 active site 479435001559 MgATP binding site [chemical binding]; other site 479435001560 catalytic site [active] 479435001561 metal binding site [ion binding]; metal-binding site 479435001562 carbohydrate binding site [chemical binding]; other site 479435001563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435001564 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 479435001565 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 479435001566 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 479435001567 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 479435001568 dimer interface [polypeptide binding]; other site 479435001569 active site 479435001570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435001571 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435001572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435001573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001574 dimer interface [polypeptide binding]; other site 479435001575 conserved gate region; other site 479435001576 putative PBP binding loops; other site 479435001577 ABC-ATPase subunit interface; other site 479435001578 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001580 dimer interface [polypeptide binding]; other site 479435001581 conserved gate region; other site 479435001582 putative PBP binding loops; other site 479435001583 ABC-ATPase subunit interface; other site 479435001584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435001585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435001586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435001587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435001588 DNA binding site [nucleotide binding] 479435001589 domain linker motif; other site 479435001590 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435001591 ligand binding site [chemical binding]; other site 479435001592 dimerization interface [polypeptide binding]; other site 479435001593 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435001594 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435001595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435001596 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435001597 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479435001598 Probable Catalytic site [active] 479435001599 metal binding site [ion binding]; metal-binding site 479435001600 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001601 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001602 putative active site [active] 479435001603 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 479435001604 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 479435001605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001606 active site 479435001607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435001608 active site 479435001609 motif I; other site 479435001610 motif II; other site 479435001611 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001612 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001613 putative active site [active] 479435001614 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479435001615 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 479435001616 putative ADP-binding pocket [chemical binding]; other site 479435001617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435001618 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 479435001619 dimer interface [polypeptide binding]; other site 479435001620 active site 479435001621 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 479435001622 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435001623 substrate binding site [chemical binding]; other site 479435001624 ATP binding site [chemical binding]; other site 479435001625 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435001626 active site 479435001627 nucleotide binding site [chemical binding]; other site 479435001628 HIGH motif; other site 479435001629 KMSKS motif; other site 479435001630 classical (c) SDRs; Region: SDR_c; cd05233 479435001631 short chain dehydrogenase; Provisional; Region: PRK08219 479435001632 NAD(P) binding site [chemical binding]; other site 479435001633 active site 479435001634 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001635 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001636 putative active site [active] 479435001637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435001638 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 479435001639 NAD binding site [chemical binding]; other site 479435001640 putative substrate binding site 2 [chemical binding]; other site 479435001641 putative substrate binding site 1 [chemical binding]; other site 479435001642 active site 479435001643 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435001644 anti sigma factor interaction site; other site 479435001645 regulatory phosphorylation site [posttranslational modification]; other site 479435001646 Uncharacterized conserved protein [Function unknown]; Region: COG5276 479435001647 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435001648 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435001649 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435001650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001651 NAD(P) binding site [chemical binding]; other site 479435001652 active site 479435001653 A new structural DNA glycosylase; Region: AlkD_like; cd06561 479435001654 Active site [active] 479435001655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001656 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001657 putative substrate translocation pore; other site 479435001658 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435001659 active site 479435001660 catalytic site [active] 479435001661 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 479435001662 active site triad [active] 479435001663 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 479435001664 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435001665 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435001666 AzlC protein; Region: AzlC; cl00570 479435001667 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 479435001668 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435001669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001670 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435001671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435001672 DNA binding residues [nucleotide binding] 479435001673 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435001674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001675 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435001676 substrate binding pocket [chemical binding]; other site 479435001677 dimerization interface [polypeptide binding]; other site 479435001678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001679 S-adenosylmethionine binding site [chemical binding]; other site 479435001680 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435001681 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479435001682 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 479435001683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435001684 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435001685 GAF domain; Region: GAF; cl00853 479435001686 ANTAR domain; Region: ANTAR; cl04297 479435001687 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 479435001688 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 479435001689 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 479435001690 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 479435001691 metal ion-dependent adhesion site (MIDAS); other site 479435001692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001693 YCII-related domain; Region: YCII; cl00999 479435001694 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 479435001695 putative hydrophobic ligand binding site [chemical binding]; other site 479435001696 TIGR03086 family protein; Region: TIGR03086 479435001697 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479435001698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001699 active site 479435001700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435001702 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435001703 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 479435001704 malate synthase A; Region: malate_syn_A; TIGR01344 479435001705 active site 479435001706 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 479435001707 cleavage site 479435001708 active site 479435001709 substrate binding sites [chemical binding]; other site 479435001710 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 479435001711 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 479435001712 ANTAR domain; Region: ANTAR; cl04297 479435001713 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 479435001714 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435001715 trehalose synthase; Region: treS_nterm; TIGR02456 479435001716 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435001717 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor...; Region: ZnMc_pappalysin_like; cd04275 479435001718 active site 479435001719 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 479435001720 active site 479435001721 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435001722 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 479435001723 DXD motif; other site 479435001724 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 479435001725 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435001726 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 479435001727 RHS Repeat; Region: RHS_repeat; cl11982 479435001728 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435001729 RHS Repeat; Region: RHS_repeat; cl11982 479435001730 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435001731 putative metal binding site [ion binding]; other site 479435001732 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435001733 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 479435001734 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479435001735 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 479435001736 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435001737 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 479435001738 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435001739 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 479435001740 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 479435001741 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 479435001742 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435001743 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 479435001744 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 479435001745 putative dimer interface [polypeptide binding]; other site 479435001746 pectinesterase/pectinesterase inhibitor; Region: PLN02301 479435001747 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435001748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435001749 Walker A motif; other site 479435001750 ATP binding site [chemical binding]; other site 479435001751 Walker B motif; other site 479435001752 arginine finger; other site 479435001753 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 479435001754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001755 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479435001756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001757 active site 479435001758 phosphorylation site [posttranslational modification] 479435001759 intermolecular recognition site; other site 479435001760 dimerization interface [polypeptide binding]; other site 479435001761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435001762 DNA binding site [nucleotide binding] 479435001763 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 479435001764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 479435001765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001766 ATP binding site [chemical binding]; other site 479435001767 Mg2+ binding site [ion binding]; other site 479435001768 G-X-G motif; other site 479435001769 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435001770 Interdomain contacts; other site 479435001771 Cytokine receptor motif; other site 479435001772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435001773 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435001775 Walker A motif; other site 479435001776 ATP binding site [chemical binding]; other site 479435001777 Walker B motif; other site 479435001778 arginine finger; other site 479435001779 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435001780 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435001781 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 479435001782 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435001783 substrate binding site [chemical binding]; other site 479435001784 activation loop (A-loop); other site 479435001785 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 479435001786 Protein of unknown function (DUF571); Region: DUF571; pfam04600 479435001787 Protein of unknown function (DUF690); Region: DUF690; cl04939 479435001788 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435001789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001790 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479435001791 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001792 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001793 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435001794 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435001795 active site 479435001796 catalytic residues [active] 479435001797 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 479435001798 Penicillin amidase; Region: Penicil_amidase; pfam01804 479435001799 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 479435001800 active site 479435001801 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 479435001802 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435001803 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435001804 FAD binding pocket [chemical binding]; other site 479435001805 FAD binding motif [chemical binding]; other site 479435001806 phosphate binding motif [ion binding]; other site 479435001807 NAD binding pocket [chemical binding]; other site 479435001808 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435001809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001810 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 479435001811 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 479435001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001813 dimer interface [polypeptide binding]; other site 479435001814 conserved gate region; other site 479435001815 putative PBP binding loops; other site 479435001816 ABC-ATPase subunit interface; other site 479435001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435001818 dimer interface [polypeptide binding]; other site 479435001819 conserved gate region; other site 479435001820 putative PBP binding loops; other site 479435001821 ABC-ATPase subunit interface; other site 479435001822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435001823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435001824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435001825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435001826 DNA binding site [nucleotide binding] 479435001827 domain linker motif; other site 479435001828 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435001829 dimerization interface [polypeptide binding]; other site 479435001830 ligand binding site [chemical binding]; other site 479435001831 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001833 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435001834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435001835 active site 479435001836 catalytic tetrad [active] 479435001837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001839 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435001840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435001841 active site 479435001842 catalytic tetrad [active] 479435001843 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435001844 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 479435001845 DNA binding residues [nucleotide binding] 479435001846 putative dimer interface [polypeptide binding]; other site 479435001847 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 479435001848 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435001849 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435001850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001851 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435001852 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435001853 GAF domain; Region: GAF; cl00853 479435001854 ANTAR domain; Region: ANTAR; cl04297 479435001855 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 479435001856 active site residue [active] 479435001857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435001858 non-specific DNA binding site [nucleotide binding]; other site 479435001859 salt bridge; other site 479435001860 sequence-specific DNA binding site [nucleotide binding]; other site 479435001861 HipA N-terminal domain; Region: couple_hipA; TIGR03071 479435001862 HipA-like N-terminal domain; Region: HipA_N; pfam07805 479435001863 HipA-like C-terminal domain; Region: HipA_C; pfam07804 479435001864 Tetratrico peptide repeat; Region: TPR_5; pfam12688 479435001865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435001866 binding surface 479435001867 TPR motif; other site 479435001868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435001869 active site 479435001870 metal binding site [ion binding]; metal-binding site 479435001871 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001873 Walker A/P-loop; other site 479435001874 ATP binding site [chemical binding]; other site 479435001875 Q-loop/lid; other site 479435001876 ABC transporter signature motif; other site 479435001877 Walker B; other site 479435001878 D-loop; other site 479435001879 H-loop/switch region; other site 479435001880 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435001881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001882 Walker A/P-loop; other site 479435001883 ATP binding site [chemical binding]; other site 479435001884 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001885 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435001886 ABC transporter; Region: ABC_tran_2; pfam12848 479435001887 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435001888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001889 S-adenosylmethionine binding site [chemical binding]; other site 479435001890 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435001891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 479435001892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435001893 catalytic residue [active] 479435001894 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 479435001895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435001896 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435001897 active site 479435001898 substrate binding site [chemical binding]; other site 479435001899 ATP binding site [chemical binding]; other site 479435001900 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435001901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435001902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001903 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435001904 Walker A/P-loop; other site 479435001905 ATP binding site [chemical binding]; other site 479435001906 Q-loop/lid; other site 479435001907 ABC transporter signature motif; other site 479435001908 Walker B; other site 479435001909 D-loop; other site 479435001910 H-loop/switch region; other site 479435001911 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 479435001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435001913 active site 479435001914 phosphorylation site [posttranslational modification] 479435001915 intermolecular recognition site; other site 479435001916 dimerization interface [polypeptide binding]; other site 479435001917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435001918 DNA binding residues [nucleotide binding] 479435001919 dimerization interface [polypeptide binding]; other site 479435001920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435001921 Histidine kinase; Region: HisKA_3; pfam07730 479435001922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435001923 ATP binding site [chemical binding]; other site 479435001924 putative Mg++ binding site [ion binding]; other site 479435001925 ATP-dependent helicase HepA; Validated; Region: PRK04914 479435001926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435001929 nucleotide binding region [chemical binding]; other site 479435001930 ATP-binding site [chemical binding]; other site 479435001931 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 479435001932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435001933 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 479435001934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435001935 ATP-binding site [chemical binding]; other site 479435001936 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 479435001937 putative active site [active] 479435001938 catalytic site [active] 479435001939 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 479435001940 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 479435001941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435001942 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 479435001943 Ligand Binding Site [chemical binding]; other site 479435001944 DGQHR domain; Region: DGQHR; cl14002 479435001945 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 479435001946 DGQHR domain; Region: DGQHR; cl14002 479435001947 DGQHR domain; Region: DGQHR; cl14002 479435001948 DGQHR domain; Region: DGQHR; cl14002 479435001949 Phosphotransferase enzyme family; Region: APH; pfam01636 479435001950 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435001951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435001952 non-specific DNA binding site [nucleotide binding]; other site 479435001953 salt bridge; other site 479435001954 sequence-specific DNA binding site [nucleotide binding]; other site 479435001955 Alkylmercury lyase; Region: MerB; pfam03243 479435001956 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435001957 DNA binding residues [nucleotide binding] 479435001958 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435001959 dimer interface [polypeptide binding]; other site 479435001960 mercury binding site [ion binding]; other site 479435001961 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435001962 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435001964 DNA binding residues [nucleotide binding] 479435001965 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 479435001966 ANTAR domain; Region: ANTAR; cl04297 479435001967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435001968 dimerization interface [polypeptide binding]; other site 479435001969 putative DNA binding site [nucleotide binding]; other site 479435001970 putative Zn2+ binding site [ion binding]; other site 479435001971 Flavin Reductases; Region: FlaRed; cl00801 479435001972 N-acetyltransferase; Region: Acetyltransf_2; cl00949 479435001973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435001975 dimerization interface [polypeptide binding]; other site 479435001976 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435001977 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435001978 homotrimer interaction site [polypeptide binding]; other site 479435001979 putative active site [active] 479435001980 Beta-lactamase; Region: Beta-lactamase; cl01009 479435001981 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 479435001982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435001983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435001984 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435001985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435001986 DNA-binding site [nucleotide binding]; DNA binding site 479435001987 UTRA domain; Region: UTRA; cl01230 479435001988 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 479435001989 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435001990 domain; Region: Glyco_hydro_2; pfam00703 479435001991 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435001992 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435001993 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 479435001994 active site 479435001995 Beta-lactamase; Region: Beta-lactamase; cl01009 479435001996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435001997 S-adenosylmethionine binding site [chemical binding]; other site 479435001998 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 479435001999 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 479435002000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435002001 Putative esterase; Region: Esterase; pfam00756 479435002002 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 479435002003 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435002004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002006 active site 479435002007 phosphorylation site [posttranslational modification] 479435002008 intermolecular recognition site; other site 479435002009 dimerization interface [polypeptide binding]; other site 479435002010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435002011 DNA binding residues [nucleotide binding] 479435002012 dimerization interface [polypeptide binding]; other site 479435002013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002014 Histidine kinase; Region: HisKA_3; pfam07730 479435002015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435002016 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 479435002017 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148 479435002018 primary dimer interface [polypeptide binding]; other site 479435002019 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 479435002020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002021 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 479435002022 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435002023 active sites [active] 479435002024 tetramer interface [polypeptide binding]; other site 479435002025 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 479435002026 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 479435002027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002028 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435002029 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 479435002030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002031 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435002032 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435002033 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435002034 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435002035 NAD(P) binding site [chemical binding]; other site 479435002036 catalytic residues [active] 479435002037 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 479435002038 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479435002039 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 479435002040 TPP-binding site [chemical binding]; other site 479435002041 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435002042 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479435002043 PYR/PP interface [polypeptide binding]; other site 479435002044 dimer interface [polypeptide binding]; other site 479435002045 TPP binding site [chemical binding]; other site 479435002046 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435002047 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002049 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435002050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002051 putative substrate translocation pore; other site 479435002052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435002053 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 479435002054 potential catalytic triad [active] 479435002055 conserved cys residue [active] 479435002056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435002059 dimerization interface [polypeptide binding]; other site 479435002060 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 479435002061 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 479435002062 putative DNA binding site [nucleotide binding]; other site 479435002063 putative homodimer interface [polypeptide binding]; other site 479435002064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435002065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435002066 CsbD-like; Region: CsbD; cl01272 479435002067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435002068 DNA binding site [nucleotide binding] 479435002069 Int/Topo IB signature motif; other site 479435002070 active site 479435002071 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435002072 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435002073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435002074 NAD binding site [chemical binding]; other site 479435002075 catalytic Zn binding site [ion binding]; other site 479435002076 structural Zn binding site [ion binding]; other site 479435002077 putative phosphoketolase; Provisional; Region: PRK05261 479435002078 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 479435002079 TPP-binding site; other site 479435002080 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 479435002081 XFP C-terminal domain; Region: XFP_C; pfam09363 479435002082 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435002083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435002085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435002086 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 479435002087 Fe-S cluster binding site [ion binding]; other site 479435002088 active site 479435002089 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435002090 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479435002091 NIPSNAP; Region: NIPSNAP; pfam07978 479435002092 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 479435002093 ATP binding site [chemical binding]; other site 479435002094 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 479435002095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002098 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 479435002099 putative active site [active] 479435002100 catalytic site [active] 479435002101 putative metal binding site [ion binding]; other site 479435002102 OsmC-like protein; Region: OsmC; cl00767 479435002103 Predicted membrane protein [Function unknown]; Region: COG4129 479435002104 Cytochrome P450; Region: p450; cl12078 479435002105 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 479435002106 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 479435002107 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 479435002108 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 479435002109 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 479435002110 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435002111 sensory histidine kinase CreC; Provisional; Region: PRK11100 479435002112 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435002113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435002114 dimer interface [polypeptide binding]; other site 479435002115 phosphorylation site [posttranslational modification] 479435002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002117 ATP binding site [chemical binding]; other site 479435002118 Mg2+ binding site [ion binding]; other site 479435002119 G-X-G motif; other site 479435002120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002122 active site 479435002123 phosphorylation site [posttranslational modification] 479435002124 intermolecular recognition site; other site 479435002125 dimerization interface [polypeptide binding]; other site 479435002126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435002127 DNA binding site [nucleotide binding] 479435002128 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435002129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435002130 substrate binding pocket [chemical binding]; other site 479435002131 membrane-bound complex binding site; other site 479435002132 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435002133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435002134 active site 479435002135 catalytic tetrad [active] 479435002136 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002137 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435002138 active site 479435002139 ATP binding site [chemical binding]; other site 479435002140 Flavin Reductases; Region: FlaRed; cl00801 479435002141 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479435002142 Moco binding site; other site 479435002143 metal coordination site [ion binding]; other site 479435002144 Fasciclin domain; Region: Fasciclin; cl02663 479435002145 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 479435002146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002147 EamA-like transporter family; Region: EamA; cl01037 479435002148 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435002149 EamA-like transporter family; Region: EamA; cl01037 479435002150 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002152 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435002153 Domain of unknown function DUF; Region: DUF202; cl09954 479435002154 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 479435002155 Phosphate transporter family; Region: PHO4; cl00396 479435002156 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435002157 putative acyl-acceptor binding pocket; other site 479435002158 ThiC family; Region: ThiC; cl08031 479435002159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002160 RDD family; Region: RDD; cl00746 479435002161 RDD family; Region: RDD; cl00746 479435002162 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 479435002163 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 479435002164 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 479435002165 Walker A/P-loop; other site 479435002166 ATP binding site [chemical binding]; other site 479435002167 Q-loop/lid; other site 479435002168 ABC transporter signature motif; other site 479435002169 Walker B; other site 479435002170 D-loop; other site 479435002171 H-loop/switch region; other site 479435002172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002173 dimer interface [polypeptide binding]; other site 479435002174 conserved gate region; other site 479435002175 putative PBP binding loops; other site 479435002176 ABC-ATPase subunit interface; other site 479435002177 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 479435002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002179 dimer interface [polypeptide binding]; other site 479435002180 conserved gate region; other site 479435002181 putative PBP binding loops; other site 479435002182 ABC-ATPase subunit interface; other site 479435002183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002184 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 479435002185 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 479435002186 active site 479435002187 Ap6A binding site [chemical binding]; other site 479435002188 nudix motif; other site 479435002189 metal binding site [ion binding]; metal-binding site 479435002190 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 479435002191 catalytic core [active] 479435002192 polyphosphate kinase; Provisional; Region: PRK05443 479435002193 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 479435002194 putative domain interface [polypeptide binding]; other site 479435002195 putative active site [active] 479435002196 catalytic site [active] 479435002197 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 479435002198 putative domain interface [polypeptide binding]; other site 479435002199 putative active site [active] 479435002200 catalytic site [active] 479435002201 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435002202 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435002203 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435002204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002205 Coenzyme A binding pocket [chemical binding]; other site 479435002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435002207 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 479435002208 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 479435002209 putative active site [active] 479435002210 putative metal binding site [ion binding]; other site 479435002211 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 479435002212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435002213 DNA binding site [nucleotide binding] 479435002214 Ubiquitin-like proteins; Region: UBQ; cl00155 479435002215 charged pocket; other site 479435002216 hydrophobic patch; other site 479435002217 RF-1 domain; Region: RF-1; cl02875 479435002218 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435002219 catalytic residues [active] 479435002220 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 479435002221 RDD family; Region: RDD; cl00746 479435002222 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479435002223 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 479435002224 active site residue [active] 479435002225 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479435002226 active site residue [active] 479435002227 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 479435002228 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 479435002229 dimerization interface [polypeptide binding]; other site 479435002230 putative tRNAtyr binding site [nucleotide binding]; other site 479435002231 putative active site [active] 479435002232 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 479435002233 DsrE/DsrF-like family; Region: DrsE; cl00672 479435002234 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 479435002235 heme-binding site [chemical binding]; other site 479435002236 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 479435002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002238 active site 479435002239 phosphorylation site [posttranslational modification] 479435002240 intermolecular recognition site; other site 479435002241 dimerization interface [polypeptide binding]; other site 479435002242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002243 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 479435002244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 479435002245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002246 ATP binding site [chemical binding]; other site 479435002247 Mg2+ binding site [ion binding]; other site 479435002248 G-X-G motif; other site 479435002249 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 479435002250 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 479435002251 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 479435002252 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479435002253 L-asparaginase II; Region: Asparaginase_II; cl01842 479435002254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002255 non-specific DNA binding site [nucleotide binding]; other site 479435002256 salt bridge; other site 479435002257 sequence-specific DNA binding site [nucleotide binding]; other site 479435002258 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 479435002259 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435002260 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435002261 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 479435002262 ADP-ribose binding site [chemical binding]; other site 479435002263 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435002264 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 479435002265 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 479435002266 G1 box; other site 479435002267 putative GEF interaction site [polypeptide binding]; other site 479435002268 GTP/Mg2+ binding site [chemical binding]; other site 479435002269 Switch I region; other site 479435002270 G2 box; other site 479435002271 G3 box; other site 479435002272 Switch II region; other site 479435002273 G4 box; other site 479435002274 G5 box; other site 479435002275 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 479435002276 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 479435002277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002280 NAD(P) binding site [chemical binding]; other site 479435002281 active site 479435002282 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 479435002283 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 479435002284 putative ADP-binding pocket [chemical binding]; other site 479435002285 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 479435002286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435002287 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435002288 catalytic core [active] 479435002289 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 479435002290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002291 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435002292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002293 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435002294 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002295 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435002296 Walker A/P-loop; other site 479435002297 ATP binding site [chemical binding]; other site 479435002298 Q-loop/lid; other site 479435002299 ABC transporter signature motif; other site 479435002300 Walker B; other site 479435002301 D-loop; other site 479435002302 H-loop/switch region; other site 479435002303 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 479435002304 PhoU domain; Region: PhoU; pfam01895 479435002305 PhoU domain; Region: PhoU; pfam01895 479435002306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435002307 dimer interface [polypeptide binding]; other site 479435002308 phosphorylation site [posttranslational modification] 479435002309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002310 ATP binding site [chemical binding]; other site 479435002311 Mg2+ binding site [ion binding]; other site 479435002312 G-X-G motif; other site 479435002313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435002314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002315 active site 479435002316 phosphorylation site [posttranslational modification] 479435002317 intermolecular recognition site; other site 479435002318 dimerization interface [polypeptide binding]; other site 479435002319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435002320 DNA binding site [nucleotide binding] 479435002321 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 479435002322 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435002323 siderophore binding site; other site 479435002324 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 479435002325 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 479435002326 substrate binding site [chemical binding]; other site 479435002327 dimer interface [polypeptide binding]; other site 479435002328 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cl10030 479435002329 homotrimer interaction site [polypeptide binding]; other site 479435002330 zinc binding site [ion binding]; other site 479435002331 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 479435002332 N-carbamolyputrescine amidase; Region: PLN02747 479435002333 active site 479435002334 catalytic triad [active] 479435002335 dimer interface [polypeptide binding]; other site 479435002336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002337 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435002338 dimerization interface [polypeptide binding]; other site 479435002339 substrate binding pocket [chemical binding]; other site 479435002340 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479435002341 Zn binding site [ion binding]; other site 479435002342 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435002343 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435002344 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435002345 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435002346 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 479435002347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435002348 putative trimer interface [polypeptide binding]; other site 479435002349 putative CoA binding site [chemical binding]; other site 479435002350 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435002351 putative trimer interface [polypeptide binding]; other site 479435002352 putative CoA binding site [chemical binding]; other site 479435002353 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002354 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002355 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002356 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002357 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002358 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002359 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002360 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 479435002361 putative active site [active] 479435002362 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435002363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435002364 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (; Region: GH25_CH-type; cd06412 479435002365 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 479435002366 active site 479435002367 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002368 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 479435002369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435002370 active site 479435002371 HIGH motif; other site 479435002372 nucleotide binding site [chemical binding]; other site 479435002373 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479435002374 KMSKS motif; other site 479435002375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 479435002376 tRNA binding surface [nucleotide binding]; other site 479435002377 anticodon binding site; other site 479435002378 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435002379 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 479435002380 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435002381 Phd_YefM; Region: PhdYeFM; cl09153 479435002382 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435002383 putative active site [active] 479435002384 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 479435002385 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435002386 putative active site [active] 479435002387 putative metal binding site [ion binding]; other site 479435002388 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435002389 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435002390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435002393 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435002394 active site 479435002395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002396 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435002397 NAD(P) binding site [chemical binding]; other site 479435002398 active site 479435002399 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435002400 putative active site [active] 479435002401 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435002402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435002404 DNA binding residues [nucleotide binding] 479435002405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435002406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435002407 DNA binding site [nucleotide binding] 479435002408 domain linker motif; other site 479435002409 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 479435002410 putative dimerization interface [polypeptide binding]; other site 479435002411 putative ligand binding site [chemical binding]; other site 479435002412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002414 dimer interface [polypeptide binding]; other site 479435002415 conserved gate region; other site 479435002416 putative PBP binding loops; other site 479435002417 ABC-ATPase subunit interface; other site 479435002418 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002420 dimer interface [polypeptide binding]; other site 479435002421 conserved gate region; other site 479435002422 putative PBP binding loops; other site 479435002423 ABC-ATPase subunit interface; other site 479435002424 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 479435002425 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435002426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 479435002427 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479435002428 metal-binding site [ion binding] 479435002429 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435002430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435002431 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 479435002432 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479435002433 putative homotetramer interface [polypeptide binding]; other site 479435002434 putative homodimer interface [polypeptide binding]; other site 479435002435 putative allosteric switch controlling residues; other site 479435002436 putative metal binding site [ion binding]; other site 479435002437 putative homodimer-homodimer interface [polypeptide binding]; other site 479435002438 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435002439 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 479435002440 Walker A/P-loop; other site 479435002441 ATP binding site [chemical binding]; other site 479435002442 Q-loop/lid; other site 479435002443 ABC transporter signature motif; other site 479435002444 Walker B; other site 479435002445 D-loop; other site 479435002446 H-loop/switch region; other site 479435002447 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435002448 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479435002449 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 479435002450 Walker A/P-loop; other site 479435002451 ATP binding site [chemical binding]; other site 479435002452 Q-loop/lid; other site 479435002453 ABC transporter signature motif; other site 479435002454 Walker B; other site 479435002455 D-loop; other site 479435002456 H-loop/switch region; other site 479435002457 TOBE domain; Region: TOBE_2; cl01440 479435002458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435002459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435002460 DNA binding site [nucleotide binding] 479435002461 domain linker motif; other site 479435002462 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 479435002463 putative dimerization interface [polypeptide binding]; other site 479435002464 putative ligand binding site [chemical binding]; other site 479435002465 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 479435002466 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 479435002467 DNA binding residues [nucleotide binding] 479435002468 dimer interface [polypeptide binding]; other site 479435002469 [2Fe-2S] cluster binding site [ion binding]; other site 479435002470 transcription termination factor Rho; Provisional; Region: PRK12678 479435002471 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 479435002472 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435002473 ATP binding site [chemical binding]; other site 479435002474 Mg++ binding site [ion binding]; other site 479435002475 motif III; other site 479435002476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435002477 nucleotide binding region [chemical binding]; other site 479435002478 ATP-binding site [chemical binding]; other site 479435002479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435002480 Penicillin amidase; Region: Penicil_amidase; pfam01804 479435002481 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 479435002482 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 479435002483 active site 479435002484 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435002485 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 479435002486 sugar binding site [chemical binding]; other site 479435002487 Domain of unknown function (DUF74); Region: DUF74; cl00426 479435002488 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 479435002489 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 479435002490 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 479435002491 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 479435002492 trimer interface [polypeptide binding]; other site 479435002493 putative metal binding site [ion binding]; other site 479435002494 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 479435002495 proposed catalytic triad [active] 479435002496 conserved cys residue [active] 479435002497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002500 dimerization interface [polypeptide binding]; other site 479435002501 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479435002502 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435002503 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435002504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002505 hypothetical protein, TIGR02147; Region: Fsuc_second 479435002506 Predicted transcriptional regulator [Transcription]; Region: COG1959 479435002507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002510 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435002511 NAD(P) binding site [chemical binding]; other site 479435002512 active site 479435002513 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 479435002514 putative active site [active] 479435002515 ATP binding site [chemical binding]; other site 479435002516 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435002517 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 479435002518 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 479435002519 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 479435002520 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435002521 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435002522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435002524 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435002525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002526 Coenzyme A binding pocket [chemical binding]; other site 479435002527 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 479435002528 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435002529 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435002530 putative NAD(P) binding site [chemical binding]; other site 479435002531 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435002532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002533 Coenzyme A binding pocket [chemical binding]; other site 479435002534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002535 Coenzyme A binding pocket [chemical binding]; other site 479435002536 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435002537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002538 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435002539 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 479435002540 Cation transport protein; Region: TrkH; cl10514 479435002541 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 479435002542 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 479435002543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002545 NAD(P) binding site [chemical binding]; other site 479435002546 active site 479435002547 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435002548 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 479435002549 DNA binding residues [nucleotide binding] 479435002550 putative dimer interface [polypeptide binding]; other site 479435002551 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479435002552 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435002553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435002554 putative transcriptional regulator; Provisional; Region: PRK11640 479435002555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002557 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479435002558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002559 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435002560 OsmC-like protein; Region: OsmC; cl00767 479435002561 trehalose synthase; Region: treS_nterm; TIGR02456 479435002562 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435002563 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002564 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435002565 active site 479435002566 ATP binding site [chemical binding]; other site 479435002567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435002568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002569 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 479435002570 Secretory lipase; Region: LIP; pfam03583 479435002571 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435002572 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435002573 hydrophobic ligand binding site; other site 479435002574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002575 dimerization interface [polypeptide binding]; other site 479435002576 putative DNA binding site [nucleotide binding]; other site 479435002577 putative Zn2+ binding site [ion binding]; other site 479435002578 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435002579 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479435002580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002581 putative substrate translocation pore; other site 479435002582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002583 non-specific DNA binding site [nucleotide binding]; other site 479435002584 salt bridge; other site 479435002585 sequence-specific DNA binding site [nucleotide binding]; other site 479435002586 Cupin domain; Region: Cupin_2; cl09118 479435002587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435002588 S-adenosylmethionine binding site [chemical binding]; other site 479435002589 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435002590 Erythromycin esterase; Region: Erythro_esteras; pfam05139 479435002591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002592 dimerization interface [polypeptide binding]; other site 479435002593 putative DNA binding site [nucleotide binding]; other site 479435002594 putative Zn2+ binding site [ion binding]; other site 479435002595 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 479435002596 Enoylreductase; Region: PKS_ER; smart00829 479435002597 NAD(P) binding site [chemical binding]; other site 479435002598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002599 NAD(P) binding site [chemical binding]; other site 479435002600 active site 479435002601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002602 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435002603 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 479435002604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002605 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435002606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002608 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435002609 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435002610 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435002611 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435002612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435002613 DNA binding residues [nucleotide binding] 479435002614 dimerization interface [polypeptide binding]; other site 479435002615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002616 Histidine kinase; Region: HisKA_3; pfam07730 479435002617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435002618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002620 active site 479435002621 phosphorylation site [posttranslational modification] 479435002622 intermolecular recognition site; other site 479435002623 dimerization interface [polypeptide binding]; other site 479435002624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435002625 DNA binding residues [nucleotide binding] 479435002626 dimerization interface [polypeptide binding]; other site 479435002627 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435002629 substrate binding site [chemical binding]; other site 479435002630 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435002631 dimer interface [polypeptide binding]; other site 479435002632 putative PBP binding regions; other site 479435002633 ABC-ATPase subunit interface; other site 479435002634 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435002635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002636 Walker A/P-loop; other site 479435002637 ATP binding site [chemical binding]; other site 479435002638 Q-loop/lid; other site 479435002639 ABC transporter signature motif; other site 479435002640 Walker B; other site 479435002641 D-loop; other site 479435002642 H-loop/switch region; other site 479435002643 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435002644 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 479435002645 putative ligand binding residues [chemical binding]; other site 479435002646 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435002647 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435002648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002649 putative DNA binding site [nucleotide binding]; other site 479435002650 putative Zn2+ binding site [ion binding]; other site 479435002651 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435002652 putative hydrophobic ligand binding site [chemical binding]; other site 479435002653 GAF domain; Region: GAF; cl00853 479435002654 ANTAR domain; Region: ANTAR; cl04297 479435002655 ANTAR domain; Region: ANTAR; cl04297 479435002656 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435002657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435002658 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435002659 hydrophobic ligand binding site; other site 479435002660 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435002661 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435002662 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435002663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435002665 DNA binding residues [nucleotide binding] 479435002666 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435002667 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435002668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002669 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 479435002670 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435002671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002672 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002673 Walker A/P-loop; other site 479435002674 ATP binding site [chemical binding]; other site 479435002675 Q-loop/lid; other site 479435002676 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 479435002677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002678 Walker A/P-loop; other site 479435002679 ATP binding site [chemical binding]; other site 479435002680 Q-loop/lid; other site 479435002681 ABC transporter signature motif; other site 479435002682 Walker B; other site 479435002683 D-loop; other site 479435002684 H-loop/switch region; other site 479435002685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435002686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435002687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435002688 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 479435002689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002690 Walker A/P-loop; other site 479435002691 ATP binding site [chemical binding]; other site 479435002692 Q-loop/lid; other site 479435002693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002694 ABC transporter signature motif; other site 479435002695 Walker B; other site 479435002696 D-loop; other site 479435002697 H-loop/switch region; other site 479435002698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002699 Walker A/P-loop; other site 479435002700 ATP binding site [chemical binding]; other site 479435002701 Q-loop/lid; other site 479435002702 ABC transporter signature motif; other site 479435002703 Walker B; other site 479435002704 D-loop; other site 479435002705 H-loop/switch region; other site 479435002706 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435002707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435002709 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435002710 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435002711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435002713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435002714 ATP binding site [chemical binding]; other site 479435002715 putative Mg++ binding site [ion binding]; other site 479435002716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435002717 nucleotide binding region [chemical binding]; other site 479435002718 ATP-binding site [chemical binding]; other site 479435002719 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 479435002720 ANTAR domain; Region: ANTAR; cl04297 479435002721 ANTAR domain; Region: ANTAR; cl04297 479435002722 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479435002723 classical (c) SDRs; Region: SDR_c; cd05233 479435002724 NAD(P) binding site [chemical binding]; other site 479435002725 active site 479435002726 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 479435002727 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 479435002728 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435002729 active site 479435002730 substrate binding site [chemical binding]; other site 479435002731 ATP binding site [chemical binding]; other site 479435002732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002733 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 479435002734 Catalytic site [active] 479435002735 short chain dehydrogenase; Provisional; Region: PRK12746 479435002736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002737 NAD(P) binding site [chemical binding]; other site 479435002738 active site 479435002739 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435002740 active site 479435002741 ATP binding site [chemical binding]; other site 479435002742 substrate binding site [chemical binding]; other site 479435002743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002744 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435002745 EamA-like transporter family; Region: EamA; cl01037 479435002746 EamA-like transporter family; Region: EamA; cl01037 479435002747 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 479435002748 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 479435002749 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435002750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435002751 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435002752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002753 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002754 dimerization interface [polypeptide binding]; other site 479435002755 MOSC domain; Region: MOSC; pfam03473 479435002756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435002757 S-adenosylmethionine binding site [chemical binding]; other site 479435002758 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 479435002759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435002760 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435002761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435002763 NAD(P) binding site [chemical binding]; other site 479435002764 active site 479435002765 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002766 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002767 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435002768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002769 Coenzyme A binding pocket [chemical binding]; other site 479435002770 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 479435002771 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 479435002772 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 479435002773 NAD binding site [chemical binding]; other site 479435002774 sugar binding site [chemical binding]; other site 479435002775 divalent metal binding site [ion binding]; other site 479435002776 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435002777 dimer interface [polypeptide binding]; other site 479435002778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002779 D-allose kinase; Provisional; Region: PRK09698 479435002780 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435002781 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435002782 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435002783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002784 Walker A/P-loop; other site 479435002785 ATP binding site [chemical binding]; other site 479435002786 Q-loop/lid; other site 479435002787 ABC transporter signature motif; other site 479435002788 Walker B; other site 479435002789 D-loop; other site 479435002790 H-loop/switch region; other site 479435002791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435002792 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435002793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435002794 Walker A/P-loop; other site 479435002795 ATP binding site [chemical binding]; other site 479435002796 Q-loop/lid; other site 479435002797 ABC transporter signature motif; other site 479435002798 Walker B; other site 479435002799 D-loop; other site 479435002800 H-loop/switch region; other site 479435002801 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 479435002802 ligand binding site [chemical binding]; other site 479435002803 active site 479435002804 UGI interface [polypeptide binding]; other site 479435002805 catalytic site [active] 479435002806 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 479435002807 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 479435002808 ligand binding site [chemical binding]; other site 479435002809 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435002810 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435002811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435002812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002813 Coenzyme A binding pocket [chemical binding]; other site 479435002814 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 479435002815 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479435002816 Survival protein SurE; Region: SurE; cl00448 479435002817 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 479435002818 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435002819 substrate binding site [chemical binding]; other site 479435002820 ATP binding site [chemical binding]; other site 479435002821 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 479435002822 IHF dimer interface [polypeptide binding]; other site 479435002823 IHF - DNA interface [nucleotide binding]; other site 479435002824 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435002825 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 479435002826 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 479435002827 active site 479435002828 Zn binding site [ion binding]; other site 479435002829 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 479435002830 proline aminopeptidase P II; Provisional; Region: PRK10879 479435002831 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 479435002832 active site 479435002833 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 479435002834 tetramerization interface [polypeptide binding]; other site 479435002835 active site 479435002836 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 479435002837 N- and C-terminal domain interface [polypeptide binding]; other site 479435002838 active site 479435002839 MgATP binding site [chemical binding]; other site 479435002840 catalytic site [active] 479435002841 metal binding site [ion binding]; metal-binding site 479435002842 carbohydrate binding site [chemical binding]; other site 479435002843 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 479435002844 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 479435002845 active site 479435002846 homotetramer interface [polypeptide binding]; other site 479435002847 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435002848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002849 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435002850 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435002851 amidase; Provisional; Region: PRK08137 479435002852 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 479435002853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435002854 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479435002855 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435002856 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 479435002857 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435002858 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435002859 conserved cys residue [active] 479435002860 threonine synthase; Validated; Region: PRK07591 479435002861 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 479435002862 homodimer interface [polypeptide binding]; other site 479435002863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435002864 catalytic residue [active] 479435002865 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435002866 MoaE interaction surface [polypeptide binding]; other site 479435002867 MoeB interaction surface [polypeptide binding]; other site 479435002868 thiocarboxylated glycine; other site 479435002869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002870 Coenzyme A binding pocket [chemical binding]; other site 479435002871 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 479435002872 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 479435002873 putative NAD(P) binding site [chemical binding]; other site 479435002874 catalytic Zn binding site [ion binding]; other site 479435002875 structural Zn binding site [ion binding]; other site 479435002876 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435002877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002878 putative substrate translocation pore; other site 479435002879 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 479435002880 DNA-binding site [nucleotide binding]; DNA binding site 479435002881 RNA-binding motif; other site 479435002882 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435002883 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 479435002884 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435002885 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435002886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002887 putative substrate translocation pore; other site 479435002888 PspC domain; Region: PspC; cl00864 479435002889 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 479435002890 PspC domain; Region: PspC; cl00864 479435002891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002893 ATP binding site [chemical binding]; other site 479435002894 Mg2+ binding site [ion binding]; other site 479435002895 G-X-G motif; other site 479435002896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435002898 active site 479435002899 phosphorylation site [posttranslational modification] 479435002900 intermolecular recognition site; other site 479435002901 dimerization interface [polypeptide binding]; other site 479435002902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435002903 DNA binding residues [nucleotide binding] 479435002904 dimerization interface [polypeptide binding]; other site 479435002905 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 479435002906 trimer interface [polypeptide binding]; other site 479435002907 active site 479435002908 G bulge; other site 479435002909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435002910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002913 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435002914 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435002915 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435002916 DNA binding residues [nucleotide binding] 479435002917 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435002918 dimer interface [polypeptide binding]; other site 479435002919 mercury binding site [ion binding]; other site 479435002920 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 479435002921 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435002922 oligomer interface [polypeptide binding]; other site 479435002923 active site residues [active] 479435002924 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435002925 oligomer interface [polypeptide binding]; other site 479435002926 active site residues [active] 479435002927 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435002928 conserved cys residue [active] 479435002929 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435002930 homotrimer interaction site [polypeptide binding]; other site 479435002931 putative active site [active] 479435002932 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435002933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435002935 LysE type translocator; Region: LysE; cl00565 479435002936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002937 NAD(P) binding site [chemical binding]; other site 479435002938 active site 479435002939 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435002940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435002941 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435002942 dimerization interface [polypeptide binding]; other site 479435002943 substrate binding pocket [chemical binding]; other site 479435002944 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 479435002945 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435002946 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435002947 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 479435002948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435002949 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 479435002950 B12 binding site [chemical binding]; other site 479435002951 cobalt ligand [ion binding]; other site 479435002952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435002953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002955 dimer interface [polypeptide binding]; other site 479435002956 conserved gate region; other site 479435002957 putative PBP binding loops; other site 479435002958 ABC-ATPase subunit interface; other site 479435002959 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435002960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435002961 dimer interface [polypeptide binding]; other site 479435002962 conserved gate region; other site 479435002963 putative PBP binding loops; other site 479435002964 ABC-ATPase subunit interface; other site 479435002965 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435002966 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435002967 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 479435002968 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435002969 CoA-ligase; Region: Ligase_CoA; pfam00549 479435002970 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 479435002971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002972 CoA-ligase; Region: Ligase_CoA; pfam00549 479435002973 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 479435002974 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 479435002975 active site 479435002976 substrate binding site [chemical binding]; other site 479435002977 cosubstrate binding site; other site 479435002978 catalytic site [active] 479435002979 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 479435002980 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 479435002981 purine monophosphate binding site [chemical binding]; other site 479435002982 dimer interface [polypeptide binding]; other site 479435002983 putative catalytic residues [active] 479435002984 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 479435002985 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 479435002986 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435002987 Glyco_18 domain; Region: Glyco_18; smart00636 479435002988 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 479435002989 active site 479435002990 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002991 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (...; Region: APH; cd05150 479435002992 active site 479435002993 ATP binding site [chemical binding]; other site 479435002994 antibiotic binding site [chemical binding]; other site 479435002995 Pirin-related protein [General function prediction only]; Region: COG1741 479435002996 Cupin domain; Region: Cupin_2; cl09118 479435002997 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 479435002998 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435002999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003001 RHS Repeat; Region: RHS_repeat; cl11982 479435003002 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435003003 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 479435003004 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 479435003005 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 479435003006 homodimer interface [polypeptide binding]; other site 479435003007 NADP binding site [chemical binding]; other site 479435003008 substrate binding site [chemical binding]; other site 479435003009 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 479435003010 malate dehydrogenase; Provisional; Region: PRK05442 479435003011 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 479435003012 NAD(P) binding site [chemical binding]; other site 479435003013 dimer interface [polypeptide binding]; other site 479435003014 malate binding site [chemical binding]; other site 479435003015 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 479435003016 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435003017 putative active site [active] 479435003018 catalytic site [active] 479435003019 putative metal binding site [ion binding]; other site 479435003020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435003021 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 479435003022 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 479435003023 MOSC domain; Region: MOSC; pfam03473 479435003024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435003025 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435003026 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435003027 conserved cys residue [active] 479435003028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003029 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 479435003030 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 479435003031 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 479435003032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003033 NAD(P) binding site [chemical binding]; other site 479435003034 active site 479435003035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003036 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435003037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003039 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435003040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003041 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435003042 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 479435003043 galactokinase; Provisional; Region: PRK00555 479435003044 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 479435003045 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 479435003046 dimer interface [polypeptide binding]; other site 479435003047 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 479435003048 active site 479435003049 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435003050 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435003051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435003052 Transporter associated domain; Region: CorC_HlyC; cl08393 479435003053 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003055 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435003056 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435003057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435003058 active site 479435003059 ATP binding site [chemical binding]; other site 479435003060 substrate binding site [chemical binding]; other site 479435003061 activation loop (A-loop); other site 479435003062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435003063 YCII-related domain; Region: YCII; cl00999 479435003064 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435003065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435003066 Protein of unknown function (DUF805); Region: DUF805; cl01224 479435003067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435003068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435003070 active site 479435003071 phosphorylation site [posttranslational modification] 479435003072 intermolecular recognition site; other site 479435003073 dimerization interface [polypeptide binding]; other site 479435003074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435003075 DNA binding residues [nucleotide binding] 479435003076 dimerization interface [polypeptide binding]; other site 479435003077 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 479435003078 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435003079 hypothetical protein; Provisional; Region: PRK02947 479435003080 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 479435003081 putative active site [active] 479435003082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435003084 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435003085 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003087 dimer interface [polypeptide binding]; other site 479435003088 conserved gate region; other site 479435003089 putative PBP binding loops; other site 479435003090 ABC-ATPase subunit interface; other site 479435003091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003092 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435003093 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 479435003094 siderophore binding site; other site 479435003095 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 479435003096 hypothetical protein; Provisional; Region: PRK13679 479435003097 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 479435003098 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 479435003099 Beta-lactamase; Region: Beta-lactamase; cl01009 479435003100 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor...; Region: ZnMc_pappalysin_like; cd04275 479435003101 active site 479435003102 ethanolamine permease; Region: 2A0305; TIGR00908 479435003103 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435003104 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479435003105 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435003106 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435003107 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 479435003108 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 479435003109 catalytic triad [active] 479435003110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003111 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435003112 NAD(P) binding site [chemical binding]; other site 479435003113 catalytic residues [active] 479435003114 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435003115 classical (c) SDRs; Region: SDR_c; cd05233 479435003116 NAD(P) binding site [chemical binding]; other site 479435003117 active site 479435003118 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435003119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435003120 DNA-binding site [nucleotide binding]; DNA binding site 479435003121 FCD domain; Region: FCD; cl11656 479435003122 Predicted ATPase [General function prediction only]; Region: COG3899 479435003123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435003124 Walker A motif; other site 479435003125 ATP binding site [chemical binding]; other site 479435003126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435003127 DNA binding residues [nucleotide binding] 479435003128 dimerization interface [polypeptide binding]; other site 479435003129 Cupin domain; Region: Cupin_2; cl09118 479435003130 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435003131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003132 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 479435003133 SxDxEG motif; other site 479435003134 active site 479435003135 metal binding site [ion binding]; metal-binding site 479435003136 homopentamer interface [polypeptide binding]; other site 479435003137 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 479435003138 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 479435003139 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 479435003140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003141 domain; Region: Succ_DH_flav_C; pfam02910 479435003142 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 479435003143 putative Iron-sulfur protein interface [polypeptide binding]; other site 479435003144 putative proximal heme binding site [chemical binding]; other site 479435003145 putative SdhC-like subunit interface [polypeptide binding]; other site 479435003146 putative distal heme binding site [chemical binding]; other site 479435003147 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 479435003148 putative Iron-sulfur protein interface [polypeptide binding]; other site 479435003149 putative proximal heme binding site [chemical binding]; other site 479435003150 putative SdhD-like interface [polypeptide binding]; other site 479435003151 putative distal heme binding site [chemical binding]; other site 479435003152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435003153 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 479435003154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435003155 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 479435003156 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 479435003157 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 479435003158 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 479435003159 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 479435003160 metal binding site [ion binding]; metal-binding site 479435003161 putative dimer interface [polypeptide binding]; other site 479435003162 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435003163 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 479435003164 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 479435003165 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 479435003166 ligand binding site [chemical binding]; other site 479435003167 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 479435003168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003169 Walker A/P-loop; other site 479435003170 ATP binding site [chemical binding]; other site 479435003171 Q-loop/lid; other site 479435003172 ABC transporter signature motif; other site 479435003173 Walker B; other site 479435003174 D-loop; other site 479435003175 H-loop/switch region; other site 479435003176 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435003177 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479435003178 TM-ABC transporter signature motif; other site 479435003179 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 479435003180 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479435003181 TM-ABC transporter signature motif; other site 479435003182 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 479435003183 active site 479435003184 catalytic motif [active] 479435003185 Zn binding site [ion binding]; other site 479435003186 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 479435003187 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479435003188 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479435003189 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 479435003190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003191 Active site [active] 479435003192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003195 dimer interface [polypeptide binding]; other site 479435003196 conserved gate region; other site 479435003197 putative PBP binding loops; other site 479435003198 ABC-ATPase subunit interface; other site 479435003199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003201 dimer interface [polypeptide binding]; other site 479435003202 conserved gate region; other site 479435003203 putative PBP binding loops; other site 479435003204 ABC-ATPase subunit interface; other site 479435003205 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479435003206 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435003207 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435003208 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 479435003209 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 479435003210 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 479435003211 N- and C-terminal domain interface [polypeptide binding]; other site 479435003212 active site 479435003213 MgATP binding site [chemical binding]; other site 479435003214 catalytic site [active] 479435003215 metal binding site [ion binding]; metal-binding site 479435003216 carbohydrate binding site [chemical binding]; other site 479435003217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435003219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435003221 active site 479435003222 phosphorylation site [posttranslational modification] 479435003223 intermolecular recognition site; other site 479435003224 dimerization interface [polypeptide binding]; other site 479435003225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435003226 DNA binding residues [nucleotide binding] 479435003227 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435003228 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 479435003229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003231 dimerization interface [polypeptide binding]; other site 479435003232 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 479435003233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435003234 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435003235 metal ion-dependent adhesion site (MIDAS); other site 479435003236 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435003237 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435003238 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435003239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435003241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435003242 active site 479435003243 phosphorylation site [posttranslational modification] 479435003244 intermolecular recognition site; other site 479435003245 dimerization interface [polypeptide binding]; other site 479435003246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435003247 DNA binding site [nucleotide binding] 479435003248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435003249 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435003250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435003251 dimer interface [polypeptide binding]; other site 479435003252 phosphorylation site [posttranslational modification] 479435003253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435003254 ATP binding site [chemical binding]; other site 479435003255 Mg2+ binding site [ion binding]; other site 479435003256 G-X-G motif; other site 479435003257 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435003258 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435003259 Zn binding site [ion binding]; other site 479435003260 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 479435003261 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 479435003262 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435003263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003265 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 479435003266 putative dimer interface [polypeptide binding]; other site 479435003267 catalytic triad [active] 479435003268 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 479435003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435003270 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435003271 NAD(P) binding site [chemical binding]; other site 479435003272 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 479435003273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003274 NAD(P) binding site [chemical binding]; other site 479435003275 catalytic residues [active] 479435003276 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 479435003277 intersubunit interface [polypeptide binding]; other site 479435003278 active site 479435003279 catalytic residue [active] 479435003280 DinB superfamily; Region: DinB_2; cl00986 479435003281 Putative esterase; Region: Esterase; pfam00756 479435003282 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435003283 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 479435003284 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 479435003285 active site 479435003286 substrate binding site [chemical binding]; other site 479435003287 metal binding site [ion binding]; metal-binding site 479435003288 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 479435003289 putative active site pocket [active] 479435003290 dimerization interface [polypeptide binding]; other site 479435003291 putative catalytic residue [active] 479435003292 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 479435003293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003294 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435003295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435003296 active site 479435003297 ATP binding site [chemical binding]; other site 479435003298 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435003299 amidase catalytic site [active] 479435003300 Zn binding residues [ion binding]; other site 479435003301 substrate binding site [chemical binding]; other site 479435003302 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 479435003303 LGFP repeat; Region: LGFP; pfam08310 479435003304 Stage II sporulation protein; Region: SpoIID; cl07201 479435003305 Stage II sporulation protein; Region: SpoIID; cl07201 479435003306 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 479435003307 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479435003308 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479435003309 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435003310 active site 479435003311 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435003312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003314 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 479435003315 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435003316 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435003317 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 479435003318 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 479435003319 carboxyltransferase (CT) interaction site; other site 479435003320 biotinylation site [posttranslational modification]; other site 479435003321 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 479435003322 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435003323 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435003324 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435003325 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 479435003326 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 479435003327 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 479435003328 [4Fe-4S] binding site [ion binding]; other site 479435003329 molybdopterin cofactor binding site; other site 479435003330 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 479435003331 molybdopterin cofactor binding site; other site 479435003332 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 479435003333 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 479435003334 nitrite reductase subunit NirD; Provisional; Region: PRK14989 479435003335 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 479435003336 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 479435003337 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435003338 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 479435003339 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 479435003340 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 479435003341 active site 479435003342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003343 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 479435003344 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 479435003345 putative active site [active] 479435003346 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435003347 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 479435003348 DNA binding residues [nucleotide binding] 479435003349 putative dimer interface [polypeptide binding]; other site 479435003350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435003351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435003352 active site 479435003353 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435003354 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435003355 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435003356 Phosphotransferase enzyme family; Region: APH; pfam01636 479435003357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435003358 active site 479435003359 substrate binding site [chemical binding]; other site 479435003360 ATP binding site [chemical binding]; other site 479435003361 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 479435003362 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435003363 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 479435003364 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 479435003365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003367 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 479435003368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003369 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435003370 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435003371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435003374 putative substrate translocation pore; other site 479435003375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003376 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435003377 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435003378 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435003379 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 479435003380 Maf-like protein; Region: Maf; pfam02545 479435003381 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 479435003382 active site 479435003383 dimer interface [polypeptide binding]; other site 479435003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435003385 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 479435003386 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435003387 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435003388 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 479435003389 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 479435003390 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 479435003391 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 479435003392 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 479435003393 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 479435003394 Bacterial membrane flanked domain; Region: DUF304; cl01348 479435003395 GtrA-like protein; Region: GtrA; cl00971 479435003396 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 479435003397 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435003398 AIR carboxylase; Region: AIRC; cl00310 479435003399 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003400 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 479435003401 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 479435003402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435003404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435003405 active site 479435003406 Beta-lactamase; Region: Beta-lactamase; cl01009 479435003407 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435003408 active site 479435003409 catalytic triad [active] 479435003410 oxyanion hole [active] 479435003411 GAF domain; Region: GAF; cl00853 479435003412 ANTAR domain; Region: ANTAR; cl04297 479435003413 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435003414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003415 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 479435003416 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 479435003417 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435003418 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435003419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435003420 DNA binding site [nucleotide binding] 479435003421 domain linker motif; other site 479435003422 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435003423 ligand binding site [chemical binding]; other site 479435003424 dimerization interface [polypeptide binding]; other site 479435003425 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479435003426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435003428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003429 dimer interface [polypeptide binding]; other site 479435003430 conserved gate region; other site 479435003431 putative PBP binding loops; other site 479435003432 ABC-ATPase subunit interface; other site 479435003433 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003434 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 479435003435 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 479435003436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435003437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435003438 DNA binding site [nucleotide binding] 479435003439 domain linker motif; other site 479435003440 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435003441 dimerization interface [polypeptide binding]; other site 479435003442 ligand binding site [chemical binding]; other site 479435003443 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435003444 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435003445 amidase; Provisional; Region: PRK06170 479435003446 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435003447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003448 classical (c) SDRs; Region: SDR_c; cd05233 479435003449 NAD(P) binding site [chemical binding]; other site 479435003450 active site 479435003451 RNA polymerase sigma factor; Provisional; Region: PRK12519 479435003452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003453 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 479435003454 classical (c) SDRs; Region: SDR_c; cd05233 479435003455 NAD(P) binding site [chemical binding]; other site 479435003456 active site 479435003457 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 479435003458 Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955 479435003459 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435003460 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435003461 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 479435003462 protein-splicing catalytic site; other site 479435003463 thioester formation/cholesterol transfer; other site 479435003464 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 479435003465 Fasciclin domain; Region: Fasciclin; cl02663 479435003466 Anti-sigma-K factor rskA; Region: RskA; cl02208 479435003467 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 479435003468 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435003469 putative active site [active] 479435003470 putative metal binding site [ion binding]; other site 479435003471 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435003472 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435003473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435003476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003477 NAD(P) binding site [chemical binding]; other site 479435003478 active site 479435003479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003480 NAD(P) binding site [chemical binding]; other site 479435003481 active site 479435003482 transcriptional regulator NarL; Provisional; Region: PRK10651 479435003483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435003484 DNA binding residues [nucleotide binding] 479435003485 dimerization interface [polypeptide binding]; other site 479435003486 hypothetical protein; Provisional; Region: PRK09897 479435003487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003489 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435003490 NADP binding site [chemical binding]; other site 479435003491 active site 479435003492 steroid binding site; other site 479435003493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003494 NAD(P) binding site [chemical binding]; other site 479435003495 active site 479435003496 hypothetical protein; Provisional; Region: PRK08204 479435003497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435003498 active site 479435003499 short chain dehydrogenase; Provisional; Region: PRK06197 479435003500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003501 NAD(P) binding site [chemical binding]; other site 479435003502 active site 479435003503 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 479435003504 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 479435003505 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435003506 Alginate lyase; Region: Alginate_lyase2; pfam08787 479435003507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435003508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003510 dimerization interface [polypeptide binding]; other site 479435003511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435003512 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435003513 putative metal binding site [ion binding]; other site 479435003514 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435003515 active site 479435003516 catalytic site [active] 479435003517 putative alpha-glucosidase; Provisional; Region: PRK10658 479435003518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003521 dimer interface [polypeptide binding]; other site 479435003522 conserved gate region; other site 479435003523 putative PBP binding loops; other site 479435003524 ABC-ATPase subunit interface; other site 479435003525 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003527 dimer interface [polypeptide binding]; other site 479435003528 conserved gate region; other site 479435003529 putative PBP binding loops; other site 479435003530 ABC-ATPase subunit interface; other site 479435003531 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 479435003532 Ca binding site [ion binding]; other site 479435003533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003535 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435003536 catalytic site [active] 479435003537 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435003538 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435003539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435003540 S-adenosylmethionine binding site [chemical binding]; other site 479435003541 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435003542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003543 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435003544 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 479435003545 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 479435003546 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435003547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435003548 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435003549 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435003550 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435003551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003552 putative substrate translocation pore; other site 479435003553 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479435003554 putative homotetramer interface [polypeptide binding]; other site 479435003555 putative homodimer interface [polypeptide binding]; other site 479435003556 putative allosteric switch controlling residues; other site 479435003557 putative metal binding site [ion binding]; other site 479435003558 putative homodimer-homodimer interface [polypeptide binding]; other site 479435003559 hypothetical protein; Provisional; Region: PRK06834 479435003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003561 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435003562 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435003563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435003564 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 479435003565 active site 479435003566 DNA binding site [nucleotide binding] 479435003567 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 479435003568 DNA binding site [nucleotide binding] 479435003569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003570 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 479435003571 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435003572 catalytic Zn binding site [ion binding]; other site 479435003573 NAD(P) binding site [chemical binding]; other site 479435003574 structural Zn binding site [ion binding]; other site 479435003575 Domain of unknown function (DUF369); Region: DUF369; cl00950 479435003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003577 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 479435003578 putative substrate translocation pore; other site 479435003579 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 479435003580 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 479435003581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003583 NAD(P) binding site [chemical binding]; other site 479435003584 active site 479435003585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003587 putative substrate translocation pore; other site 479435003588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435003592 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435003593 hydrophobic ligand binding site; other site 479435003594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003595 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435003596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435003597 non-specific DNA binding site [nucleotide binding]; other site 479435003598 salt bridge; other site 479435003599 sequence-specific DNA binding site [nucleotide binding]; other site 479435003600 Cupin domain; Region: Cupin_2; cl09118 479435003601 AzlC protein; Region: AzlC; cl00570 479435003602 tyrosine kinase; Provisional; Region: PRK11519 479435003603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435003604 S-adenosylmethionine binding site [chemical binding]; other site 479435003605 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479435003606 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 479435003607 Ligand binding site [chemical binding]; other site 479435003608 YCII-related domain; Region: YCII; cl00999 479435003609 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435003610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435003612 DNA binding residues [nucleotide binding] 479435003613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435003614 dimerization interface [polypeptide binding]; other site 479435003615 putative DNA binding site [nucleotide binding]; other site 479435003616 putative Zn2+ binding site [ion binding]; other site 479435003617 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435003618 hydrophobic ligand binding site; other site 479435003619 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 479435003620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435003621 Walker A/P-loop; other site 479435003622 ATP binding site [chemical binding]; other site 479435003623 Q-loop/lid; other site 479435003624 ABC transporter signature motif; other site 479435003625 Walker B; other site 479435003626 D-loop; other site 479435003627 H-loop/switch region; other site 479435003628 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435003629 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 479435003630 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 479435003631 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 479435003632 active site 479435003633 NAD binding site [chemical binding]; other site 479435003634 metal binding site [ion binding]; metal-binding site 479435003635 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 479435003636 active site 479435003637 metal binding site [ion binding]; metal-binding site 479435003638 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 479435003639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003640 NAD(P) binding site [chemical binding]; other site 479435003641 active site 479435003642 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 479435003643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435003644 S-adenosylmethionine binding site [chemical binding]; other site 479435003645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435003646 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 479435003647 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 479435003648 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479435003649 homodimer interface [polypeptide binding]; other site 479435003650 substrate-cofactor binding pocket; other site 479435003651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435003652 catalytic residue [active] 479435003653 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435003654 classical (c) SDRs; Region: SDR_c; cd05233 479435003655 NAD(P) binding site [chemical binding]; other site 479435003656 active site 479435003657 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435003658 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435003659 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435003660 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435003661 Transporter associated domain; Region: CorC_HlyC; cl08393 479435003662 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435003663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435003664 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435003665 ATP-NAD kinase; Region: NAD_kinase; pfam01513 479435003666 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 479435003667 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 479435003668 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 479435003669 Substrate binding site [chemical binding]; other site 479435003670 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 479435003671 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 479435003672 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 479435003673 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 479435003674 phosphate binding site [ion binding]; other site 479435003675 dimer interface [polypeptide binding]; other site 479435003676 Transcription factor WhiB; Region: Whib; pfam02467 479435003677 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479435003678 Probable Catalytic site [active] 479435003679 metal binding site [ion binding]; metal-binding site 479435003680 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 479435003681 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 479435003682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435003683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003684 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435003685 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435003686 conserved cys residue [active] 479435003687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003688 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435003689 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 479435003690 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 479435003691 active site 479435003692 substrate binding site [chemical binding]; other site 479435003693 metal binding site [ion binding]; metal-binding site 479435003694 Trm112p-like protein; Region: Trm112p; cl01066 479435003695 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435003696 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 479435003697 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 479435003698 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 479435003699 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 479435003700 Cation efflux family; Region: Cation_efflux; cl00316 479435003701 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435003702 DNA binding residues [nucleotide binding] 479435003703 Adenosylhomocysteinase; Provisional; Region: PTZ00075 479435003704 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 479435003705 oligomerization interface [polypeptide binding]; other site 479435003706 active site 479435003707 NAD+ binding site [chemical binding]; other site 479435003708 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435003709 active site 479435003710 ATP binding site [chemical binding]; other site 479435003711 substrate binding site [chemical binding]; other site 479435003712 activation loop (A-loop); other site 479435003713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435003714 metal ion-dependent adhesion site (MIDAS); other site 479435003715 RDD family; Region: RDD; cl00746 479435003716 Integral membrane protein DUF95; Region: DUF95; cl00572 479435003717 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435003718 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435003719 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435003720 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435003721 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435003722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003724 dimer interface [polypeptide binding]; other site 479435003725 conserved gate region; other site 479435003726 putative PBP binding loops; other site 479435003727 ABC-ATPase subunit interface; other site 479435003728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435003729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003730 dimer interface [polypeptide binding]; other site 479435003731 conserved gate region; other site 479435003732 putative PBP binding loops; other site 479435003733 ABC-ATPase subunit interface; other site 479435003734 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435003735 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435003736 Walker A/P-loop; other site 479435003737 ATP binding site [chemical binding]; other site 479435003738 Q-loop/lid; other site 479435003739 ABC transporter signature motif; other site 479435003740 Walker B; other site 479435003741 D-loop; other site 479435003742 H-loop/switch region; other site 479435003743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435003744 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435003745 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435003746 Walker A/P-loop; other site 479435003747 ATP binding site [chemical binding]; other site 479435003748 Q-loop/lid; other site 479435003749 ABC transporter signature motif; other site 479435003750 Walker B; other site 479435003751 D-loop; other site 479435003752 H-loop/switch region; other site 479435003753 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435003754 MOSC domain; Region: MOSC; pfam03473 479435003755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435003756 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435003757 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435003758 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435003759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435003760 Walker A motif; other site 479435003761 ATP binding site [chemical binding]; other site 479435003762 Walker B motif; other site 479435003763 arginine finger; other site 479435003764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435003765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435003766 active site 479435003767 phosphorylation site [posttranslational modification] 479435003768 intermolecular recognition site; other site 479435003769 dimerization interface [polypeptide binding]; other site 479435003770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435003771 DNA binding site [nucleotide binding] 479435003772 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435003773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435003774 dimer interface [polypeptide binding]; other site 479435003775 phosphorylation site [posttranslational modification] 479435003776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435003777 ATP binding site [chemical binding]; other site 479435003778 Mg2+ binding site [ion binding]; other site 479435003779 G-X-G motif; other site 479435003780 lipoprotein LpqB; Provisional; Region: PRK13613 479435003781 Sporulation and spore germination; Region: Germane; cl11253 479435003782 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 479435003783 dimer interface [polypeptide binding]; other site 479435003784 ADP-ribose binding site [chemical binding]; other site 479435003785 active site 479435003786 nudix motif; other site 479435003787 metal binding site [ion binding]; metal-binding site 479435003788 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 479435003789 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435003790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003791 putative substrate translocation pore; other site 479435003792 Membrane transport protein; Region: Mem_trans; cl09117 479435003793 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435003794 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 479435003795 30S subunit binding site; other site 479435003796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435003797 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435003798 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 479435003799 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 479435003800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435003801 nucleotide binding region [chemical binding]; other site 479435003802 SEC-C motif; Region: SEC-C; cl12132 479435003803 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 479435003804 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 479435003805 FMN binding site [chemical binding]; other site 479435003806 substrate binding site [chemical binding]; other site 479435003807 putative catalytic residue [active] 479435003808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435003809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435003810 DNA binding site [nucleotide binding] 479435003811 domain linker motif; other site 479435003812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435003813 ligand binding site [chemical binding]; other site 479435003814 dimerization interface [polypeptide binding]; other site 479435003815 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003816 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435003818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003820 dimer interface [polypeptide binding]; other site 479435003821 conserved gate region; other site 479435003822 putative PBP binding loops; other site 479435003823 ABC-ATPase subunit interface; other site 479435003824 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435003825 active site 479435003826 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435003827 active site 479435003828 ATP binding site [chemical binding]; other site 479435003829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435003830 VanW like protein; Region: VanW; pfam04294 479435003831 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435003832 SAF domain; Region: SAF; cl00555 479435003833 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 479435003834 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435003835 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435003836 Uncharacterized conserved protein [Function unknown]; Region: COG3595 479435003837 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479435003838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435003839 active site 479435003840 motif I; other site 479435003841 motif II; other site 479435003842 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 479435003843 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479435003844 Condensation domain; Region: Condensation; cl09290 479435003845 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 479435003846 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 479435003847 putative DNA binding site [nucleotide binding]; other site 479435003848 putative homodimer interface [polypeptide binding]; other site 479435003849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435003850 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 479435003851 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003852 Glutamate binding site [chemical binding]; other site 479435003853 NAD binding site [chemical binding]; other site 479435003854 catalytic residues [active] 479435003855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003856 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 479435003857 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 479435003858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435003859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003860 NAD(P) binding site [chemical binding]; other site 479435003861 active site 479435003862 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435003863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435003865 short chain dehydrogenase; Provisional; Region: PRK12828 479435003866 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 479435003867 NADP binding site [chemical binding]; other site 479435003868 substrate binding site [chemical binding]; other site 479435003869 active site 479435003870 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479435003871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003872 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 479435003873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435003875 active site 479435003876 phosphorylation site [posttranslational modification] 479435003877 intermolecular recognition site; other site 479435003878 dimerization interface [polypeptide binding]; other site 479435003879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435003880 DNA binding residues [nucleotide binding] 479435003881 dimerization interface [polypeptide binding]; other site 479435003882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435003883 Histidine kinase; Region: HisKA_3; pfam07730 479435003884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435003885 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003887 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 479435003888 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435003889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435003890 DNA-binding site [nucleotide binding]; DNA binding site 479435003891 UTRA domain; Region: UTRA; cl01230 479435003892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435003893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435003895 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435003896 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435003897 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435003898 substrate binding site [chemical binding]; other site 479435003899 ATP binding site [chemical binding]; other site 479435003900 KduI/IolB family; Region: KduI; cl01508 479435003901 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 479435003902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435003903 dimer interface [polypeptide binding]; other site 479435003904 PYR/PP interface [polypeptide binding]; other site 479435003905 TPP binding site [chemical binding]; other site 479435003906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435003907 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 479435003908 TPP-binding site; other site 479435003909 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435003910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435003911 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 479435003912 putative ligand binding site [chemical binding]; other site 479435003913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435003914 TM-ABC transporter signature motif; other site 479435003915 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479435003916 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 479435003917 Walker A/P-loop; other site 479435003918 ATP binding site [chemical binding]; other site 479435003919 Q-loop/lid; other site 479435003920 ABC transporter signature motif; other site 479435003921 Walker B; other site 479435003922 D-loop; other site 479435003923 H-loop/switch region; other site 479435003924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435003925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003926 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 479435003927 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003928 tetrameric interface [polypeptide binding]; other site 479435003929 NAD binding site [chemical binding]; other site 479435003930 catalytic residues [active] 479435003931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003932 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435003933 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435003934 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435003935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003936 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435003937 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435003938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435003939 DNA-binding site [nucleotide binding]; DNA binding site 479435003940 UTRA domain; Region: UTRA; cl01230 479435003941 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435003942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435003944 DNA binding residues [nucleotide binding] 479435003945 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 479435003946 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 479435003947 ATP binding site [chemical binding]; other site 479435003948 Walker A motif; other site 479435003949 hexamer interface [polypeptide binding]; other site 479435003950 Walker B motif; other site 479435003951 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 479435003952 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 479435003953 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435003954 classical (c) SDRs; Region: SDR_c; cd05233 479435003955 NAD(P) binding site [chemical binding]; other site 479435003956 active site 479435003957 peptide chain release factor 2; Validated; Region: prfB; PRK00578 479435003958 RF-1 domain; Region: RF-1; cl02875 479435003959 RF-1 domain; Region: RF-1; cl02875 479435003960 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435003961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435003962 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 479435003963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435003964 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435003965 putative dimerization interface [polypeptide binding]; other site 479435003966 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 479435003967 EamA-like transporter family; Region: EamA; cl01037 479435003968 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cl00137 479435003969 reactive center loop; other site 479435003970 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 479435003971 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 479435003972 hypothetical protein; Provisional; Region: PHA03169 479435003973 Predicted permease; Region: DUF318; cl00487 479435003974 Predicted permease; Region: DUF318; cl00487 479435003975 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cl00137 479435003976 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cl00137 479435003977 reactive center loop; other site 479435003978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003979 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 479435003980 putative hydrophobic ligand binding site [chemical binding]; other site 479435003981 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 479435003982 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 479435003983 N-carbamolyputrescine amidase; Region: PLN02747 479435003984 active site 479435003985 catalytic triad [active] 479435003986 dimer interface [polypeptide binding]; other site 479435003987 phenylhydantoinase; Validated; Region: PRK08323 479435003988 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 479435003989 tetramer interface [polypeptide binding]; other site 479435003990 active site 479435003991 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435003992 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 479435003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435003994 dimer interface [polypeptide binding]; other site 479435003995 conserved gate region; other site 479435003996 putative PBP binding loops; other site 479435003997 ABC-ATPase subunit interface; other site 479435003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435003999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004001 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 479435004002 Histidine kinase; Region: His_kinase; pfam06580 479435004003 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 479435004004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004005 active site 479435004006 phosphorylation site [posttranslational modification] 479435004007 intermolecular recognition site; other site 479435004008 dimerization interface [polypeptide binding]; other site 479435004009 LytTr DNA-binding domain; Region: LytTR; cl04498 479435004010 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 479435004011 substrate binding site [chemical binding]; other site 479435004012 ATP binding site [chemical binding]; other site 479435004013 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 479435004014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004015 Walker A/P-loop; other site 479435004016 ATP binding site [chemical binding]; other site 479435004017 Q-loop/lid; other site 479435004018 ABC transporter signature motif; other site 479435004019 Walker B; other site 479435004020 D-loop; other site 479435004021 H-loop/switch region; other site 479435004022 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 479435004023 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435004024 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 479435004025 SmpB-tmRNA interface; other site 479435004026 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435004027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 479435004028 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435004029 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435004030 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435004031 putative hydrophobic ligand binding site [chemical binding]; other site 479435004032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004033 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 479435004034 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 479435004035 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435004036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435004037 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004039 dimer interface [polypeptide binding]; other site 479435004040 conserved gate region; other site 479435004041 putative PBP binding loops; other site 479435004042 ABC-ATPase subunit interface; other site 479435004043 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004045 Protein of unknown function (DUF990); Region: DUF990; cl01496 479435004046 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 479435004047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004048 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435004049 Walker A/P-loop; other site 479435004050 ATP binding site [chemical binding]; other site 479435004051 Q-loop/lid; other site 479435004052 ABC transporter signature motif; other site 479435004053 Walker B; other site 479435004054 D-loop; other site 479435004055 H-loop/switch region; other site 479435004056 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435004057 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435004058 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435004059 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435004060 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 479435004061 Moco binding site; other site 479435004062 metal coordination site [ion binding]; other site 479435004063 dimerization interface [polypeptide binding]; other site 479435004064 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479435004065 EamA-like transporter family; Region: EamA; cl01037 479435004066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004067 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 479435004068 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435004069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004070 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004071 transcriptional regulator MerD; Provisional; Region: PRK13749 479435004072 DNA binding residues [nucleotide binding] 479435004073 short chain dehydrogenase; Provisional; Region: PRK07576 479435004074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004075 NAD(P) binding site [chemical binding]; other site 479435004076 active site 479435004077 short chain dehydrogenase; Validated; Region: PRK05855 479435004078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435004079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004080 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435004081 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435004082 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 479435004083 Walker A/P-loop; other site 479435004084 ATP binding site [chemical binding]; other site 479435004085 Q-loop/lid; other site 479435004086 ABC transporter signature motif; other site 479435004087 Walker B; other site 479435004088 D-loop; other site 479435004089 H-loop/switch region; other site 479435004090 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435004091 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435004092 TM-ABC transporter signature motif; other site 479435004093 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 479435004094 putative ligand binding site [chemical binding]; other site 479435004095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004097 DNA binding site [nucleotide binding] 479435004098 domain linker motif; other site 479435004099 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004100 dimerization interface [polypeptide binding]; other site 479435004101 ligand binding site [chemical binding]; other site 479435004102 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435004103 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479435004104 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 479435004105 putative NAD(P) binding site [chemical binding]; other site 479435004106 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 479435004107 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 479435004108 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435004109 putative active site [active] 479435004110 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 479435004111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435004112 ATP binding site [chemical binding]; other site 479435004113 putative Mg++ binding site [ion binding]; other site 479435004114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004116 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 479435004117 NAD(P) binding site [chemical binding]; other site 479435004118 active site 479435004119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004120 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435004121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004122 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 479435004123 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479435004124 dimer interface [polypeptide binding]; other site 479435004125 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 479435004126 active site 479435004127 Fe binding site [ion binding]; other site 479435004128 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004129 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479435004130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435004131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004132 active site 479435004133 phosphorylation site [posttranslational modification] 479435004134 intermolecular recognition site; other site 479435004135 dimerization interface [polypeptide binding]; other site 479435004136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435004137 DNA binding site [nucleotide binding] 479435004138 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435004139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435004140 dimer interface [polypeptide binding]; other site 479435004141 phosphorylation site [posttranslational modification] 479435004142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435004143 ATP binding site [chemical binding]; other site 479435004144 Mg2+ binding site [ion binding]; other site 479435004145 G-X-G motif; other site 479435004146 fumarylacetoacetase; Region: PLN02856 479435004147 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 479435004148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479435004149 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 479435004150 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 479435004151 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 479435004152 active site 479435004153 metal binding site [ion binding]; metal-binding site 479435004154 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 479435004155 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 479435004156 Isochorismatase family; Region: Isochorismatase; pfam00857 479435004157 catalytic triad [active] 479435004158 metal binding site [ion binding]; metal-binding site 479435004159 conserved cis-peptide bond; other site 479435004160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435004161 classical (c) SDRs; Region: SDR_c; cd05233 479435004162 NAD(P) binding site [chemical binding]; other site 479435004163 active site 479435004164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004165 NAD(P) binding site [chemical binding]; other site 479435004166 active site 479435004167 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 479435004168 Zn binding site [ion binding]; other site 479435004169 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 479435004170 Zn binding site [ion binding]; other site 479435004171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435004172 DNA binding residues [nucleotide binding] 479435004173 dimerization interface [polypeptide binding]; other site 479435004174 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 479435004175 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435004176 NADP binding site [chemical binding]; other site 479435004177 active site 479435004178 steroid binding site; other site 479435004179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004181 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435004182 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 479435004183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004185 DNA binding site [nucleotide binding] 479435004186 domain linker motif; other site 479435004187 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435004188 putative dimerization interface [polypeptide binding]; other site 479435004189 putative ligand binding site [chemical binding]; other site 479435004190 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004192 dimer interface [polypeptide binding]; other site 479435004193 conserved gate region; other site 479435004194 putative PBP binding loops; other site 479435004195 ABC-ATPase subunit interface; other site 479435004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435004197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004198 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 479435004199 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 479435004200 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435004201 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 479435004202 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 479435004203 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 479435004204 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004205 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 479435004206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004208 DNA binding site [nucleotide binding] 479435004209 domain linker motif; other site 479435004210 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004211 dimerization interface [polypeptide binding]; other site 479435004212 ligand binding site [chemical binding]; other site 479435004213 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004216 dimer interface [polypeptide binding]; other site 479435004217 conserved gate region; other site 479435004218 putative PBP binding loops; other site 479435004219 ABC-ATPase subunit interface; other site 479435004220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004221 dimer interface [polypeptide binding]; other site 479435004222 conserved gate region; other site 479435004223 putative PBP binding loops; other site 479435004224 ABC-ATPase subunit interface; other site 479435004225 putative alpha-glucosidase; Provisional; Region: PRK10658 479435004226 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 479435004227 active site 479435004228 homotrimer interface [polypeptide binding]; other site 479435004229 catalytic site [active] 479435004230 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 479435004231 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435004232 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435004233 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435004234 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435004235 ligand binding site [chemical binding]; other site 479435004236 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435004237 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435004238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004240 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435004241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435004242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004243 dimer interface [polypeptide binding]; other site 479435004244 conserved gate region; other site 479435004245 putative PBP binding loops; other site 479435004246 ABC-ATPase subunit interface; other site 479435004247 VPS10 domain; Region: VPS10; smart00602 479435004248 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 479435004249 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 479435004250 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435004251 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 479435004252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004254 DNA binding site [nucleotide binding] 479435004255 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004256 dimerization interface [polypeptide binding]; other site 479435004257 ligand binding site [chemical binding]; other site 479435004258 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 479435004259 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004261 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 479435004262 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 479435004263 active site 479435004264 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 479435004265 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 479435004266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435004267 active site 479435004268 catalytic tetrad [active] 479435004269 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 479435004270 MPN+ (JAMM) motif; other site 479435004271 Zinc-binding site [ion binding]; other site 479435004272 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435004273 MoaE interaction surface [polypeptide binding]; other site 479435004274 MoeB interaction surface [polypeptide binding]; other site 479435004275 thiocarboxylated glycine; other site 479435004276 cysteine synthases; Region: cysKM; TIGR01136 479435004277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 479435004278 dimer interface [polypeptide binding]; other site 479435004279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004280 catalytic residue [active] 479435004281 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 479435004282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435004283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435004286 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 479435004287 active site 479435004288 catalytic triad [active] 479435004289 oxyanion hole [active] 479435004290 ribonuclease PH; Reviewed; Region: rph; PRK00173 479435004291 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 479435004292 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 479435004293 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 479435004294 active site 479435004295 dimerization interface [polypeptide binding]; other site 479435004296 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435004297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435004298 Coenzyme A binding pocket [chemical binding]; other site 479435004299 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435004300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004301 putative substrate translocation pore; other site 479435004302 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 479435004303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 479435004305 putative dimerization interface [polypeptide binding]; other site 479435004306 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435004308 Walker A motif; other site 479435004309 ATP binding site [chemical binding]; other site 479435004310 Walker B motif; other site 479435004311 arginine finger; other site 479435004312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435004313 metal ion-dependent adhesion site (MIDAS); other site 479435004314 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 479435004315 catalytic triad [active] 479435004316 Glucose dehydrogenase; Region: glucose_DH; cd08230 479435004317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435004318 NADP binding site [chemical binding]; other site 479435004319 catalytic Zn binding site [ion binding]; other site 479435004320 structural Zn binding site [ion binding]; other site 479435004321 dimer interface [polypeptide binding]; other site 479435004322 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 479435004323 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 479435004324 oligomerisation interface [polypeptide binding]; other site 479435004325 mobile loop; other site 479435004326 roof hairpin; other site 479435004327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004328 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004329 aspartate aminotransferase; Provisional; Region: PRK07681 479435004330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435004331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004332 homodimer interface [polypeptide binding]; other site 479435004333 catalytic residue [active] 479435004334 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 479435004335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 479435004336 dimer interface [polypeptide binding]; other site 479435004337 active site 479435004338 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435004339 substrate binding site [chemical binding]; other site 479435004340 catalytic residue [active] 479435004341 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 479435004342 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004343 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 479435004344 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435004345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435004346 putative dimer interface [polypeptide binding]; other site 479435004347 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 479435004348 dimer interface [polypeptide binding]; other site 479435004349 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 479435004350 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435004351 tetramer interface [polypeptide binding]; other site 479435004352 active site 479435004353 Mg2+/Mn2+ binding site [ion binding]; other site 479435004354 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 479435004355 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 479435004356 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 479435004357 AlkA N-terminal domain; Region: AlkA_N; cl05528 479435004358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435004359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435004360 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435004361 active site 479435004362 catalytic tetrad [active] 479435004363 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 479435004364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004365 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435004366 dimerization interface [polypeptide binding]; other site 479435004367 substrate binding pocket [chemical binding]; other site 479435004368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004369 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 479435004370 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 479435004371 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 479435004372 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435004373 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435004374 putative metal binding site [ion binding]; other site 479435004375 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 479435004376 active site 479435004377 Isochorismatase family; Region: Isochorismatase; pfam00857 479435004378 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435004379 catalytic triad [active] 479435004380 conserved cis-peptide bond; other site 479435004381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004382 NmrA-like family; Region: NmrA; pfam05368 479435004383 NAD(P) binding site [chemical binding]; other site 479435004384 active site 479435004385 Phosphotransferase enzyme family; Region: APH; pfam01636 479435004386 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435004387 substrate binding site [chemical binding]; other site 479435004388 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 479435004389 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435004390 active site 479435004391 nucleotide binding site [chemical binding]; other site 479435004392 HIGH motif; other site 479435004393 KMSKS motif; other site 479435004394 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 479435004395 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 479435004396 active site 479435004397 metal binding site [ion binding]; metal-binding site 479435004398 nudix motif; other site 479435004399 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 479435004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004401 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 479435004402 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435004403 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435004404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004405 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435004406 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435004407 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435004408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435004409 Cation efflux family; Region: Cation_efflux; cl00316 479435004410 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 479435004411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004412 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435004413 active site 479435004414 catalytic site [active] 479435004415 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479435004416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004418 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004420 dimer interface [polypeptide binding]; other site 479435004421 conserved gate region; other site 479435004422 putative PBP binding loops; other site 479435004423 ABC-ATPase subunit interface; other site 479435004424 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435004426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004427 dimer interface [polypeptide binding]; other site 479435004428 putative PBP binding loops; other site 479435004429 ABC-ATPase subunit interface; other site 479435004430 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004432 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435004433 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435004434 aspartate aminotransferase; Provisional; Region: PRK08361 479435004435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435004436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004437 homodimer interface [polypeptide binding]; other site 479435004438 catalytic residue [active] 479435004439 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435004440 GAF domain; Region: GAF; cl00853 479435004441 ANTAR domain; Region: ANTAR; cl04297 479435004442 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 479435004443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004444 Domain of unknown function (DUF397); Region: DUF397; pfam04149 479435004445 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435004446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435004447 S-adenosylmethionine binding site [chemical binding]; other site 479435004448 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435004449 hydrophobic ligand binding site; other site 479435004450 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 479435004451 putative dimer interface [polypeptide binding]; other site 479435004452 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435004453 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435004454 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435004455 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435004456 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 479435004457 active site 479435004458 putative catalytic site [active] 479435004459 Predicted outer membrane protein [Function unknown]; Region: COG3652 479435004460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435004462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435004463 DNA binding residues [nucleotide binding] 479435004464 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 479435004465 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 479435004466 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 479435004467 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 479435004468 oxidoreductase; Provisional; Region: PRK06128 479435004469 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 479435004470 NAD binding site [chemical binding]; other site 479435004471 metal binding site [ion binding]; metal-binding site 479435004472 active site 479435004473 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479435004474 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 479435004475 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479435004476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435004478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004479 Walker A/P-loop; other site 479435004480 ATP binding site [chemical binding]; other site 479435004481 Q-loop/lid; other site 479435004482 ABC transporter signature motif; other site 479435004483 Walker B; other site 479435004484 D-loop; other site 479435004485 H-loop/switch region; other site 479435004486 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435004487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435004489 S-adenosylmethionine binding site [chemical binding]; other site 479435004490 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435004491 dimerization interface [polypeptide binding]; other site 479435004492 putative DNA binding site [nucleotide binding]; other site 479435004493 putative Zn2+ binding site [ion binding]; other site 479435004494 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 479435004495 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004497 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435004498 Cytochrome P450; Region: p450; cl12078 479435004499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435004500 putative active site [active] 479435004501 heme pocket [chemical binding]; other site 479435004502 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 479435004503 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435004504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004505 GAF domain; Region: GAF; cl00853 479435004506 ANTAR domain; Region: ANTAR; cl04297 479435004507 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004508 DNA binding residues [nucleotide binding] 479435004509 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435004510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435004511 NAD binding site [chemical binding]; other site 479435004512 catalytic Zn binding site [ion binding]; other site 479435004513 structural Zn binding site [ion binding]; other site 479435004514 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435004515 putative catalytic site [active] 479435004516 putative metal binding site [ion binding]; other site 479435004517 putative phosphate binding site [ion binding]; other site 479435004518 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435004519 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 479435004520 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 479435004521 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 479435004522 dimerization interface [polypeptide binding]; other site 479435004523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 479435004524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435004525 ATP binding site [chemical binding]; other site 479435004526 Mg2+ binding site [ion binding]; other site 479435004527 G-X-G motif; other site 479435004528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435004529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004530 active site 479435004531 phosphorylation site [posttranslational modification] 479435004532 intermolecular recognition site; other site 479435004533 dimerization interface [polypeptide binding]; other site 479435004534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435004535 DNA binding site [nucleotide binding] 479435004536 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435004537 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 479435004538 Walker A/P-loop; other site 479435004539 ATP binding site [chemical binding]; other site 479435004540 Q-loop/lid; other site 479435004541 ABC transporter signature motif; other site 479435004542 Walker B; other site 479435004543 D-loop; other site 479435004544 H-loop/switch region; other site 479435004545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004546 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435004547 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 479435004548 NADP binding site [chemical binding]; other site 479435004549 active site 479435004550 steroid binding site; other site 479435004551 Conserved TM helix; Region: TM_helix; pfam05552 479435004552 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435004553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004554 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435004555 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435004556 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435004557 substrate binding site [chemical binding]; other site 479435004558 ATP binding site [chemical binding]; other site 479435004559 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435004560 active site 479435004561 intersubunit interface [polypeptide binding]; other site 479435004562 catalytic residue [active] 479435004563 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435004564 active site 479435004565 catalytic triad [active] 479435004566 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435004567 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435004568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004569 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435004570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004573 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004575 active site 479435004576 phosphorylation site [posttranslational modification] 479435004577 intermolecular recognition site; other site 479435004578 dimerization interface [polypeptide binding]; other site 479435004579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435004580 DNA binding residues [nucleotide binding] 479435004581 dimerization interface [polypeptide binding]; other site 479435004582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435004583 Histidine kinase; Region: HisKA_3; pfam07730 479435004584 haloalkane dehalogenase; Provisional; Region: PRK03592 479435004585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435004586 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435004587 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 479435004588 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 479435004589 DNA binding residues [nucleotide binding] 479435004590 dimer interface [polypeptide binding]; other site 479435004591 [2Fe-2S] cluster binding site [ion binding]; other site 479435004592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 479435004595 classical (c) SDRs; Region: SDR_c; cd05233 479435004596 NAD(P) binding site [chemical binding]; other site 479435004597 active site 479435004598 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435004599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004600 NAD(P) binding site [chemical binding]; other site 479435004601 active site 479435004602 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435004603 substrate binding site [chemical binding]; other site 479435004604 ATP binding site [chemical binding]; other site 479435004605 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 479435004606 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435004607 active site 479435004608 catalytic site [active] 479435004609 metal binding site [ion binding]; metal-binding site 479435004610 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435004611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004612 dimer interface [polypeptide binding]; other site 479435004613 conserved gate region; other site 479435004614 putative PBP binding loops; other site 479435004615 ABC-ATPase subunit interface; other site 479435004616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004617 dimer interface [polypeptide binding]; other site 479435004618 conserved gate region; other site 479435004619 putative PBP binding loops; other site 479435004620 ABC-ATPase subunit interface; other site 479435004621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004623 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435004624 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435004625 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 479435004626 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435004627 catalytic site [active] 479435004628 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435004629 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 479435004630 putative NAD(P) binding site [chemical binding]; other site 479435004631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435004634 Beta-lactamase; Region: Beta-lactamase; cl01009 479435004635 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479435004636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004639 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435004640 Archaeal ATPase; Region: Arch_ATPase; pfam01637 479435004641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435004643 binding surface 479435004644 TPR motif; other site 479435004645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435004647 Carboxylesterase family; Region: COesterase; pfam00135 479435004648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435004649 substrate binding pocket [chemical binding]; other site 479435004650 catalytic triad [active] 479435004651 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004652 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004653 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435004655 ABC-ATPase subunit interface; other site 479435004656 dimer interface [polypeptide binding]; other site 479435004657 putative PBP binding regions; other site 479435004658 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 479435004659 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 479435004660 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004661 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004662 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435004663 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 479435004664 intersubunit interface [polypeptide binding]; other site 479435004665 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004666 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435004667 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004668 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004669 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004670 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004671 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435004672 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435004673 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 479435004674 active site 479435004675 catalytic site [active] 479435004676 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479435004677 putative deacylase active site [active] 479435004678 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 479435004679 EamA-like transporter family; Region: EamA; cl01037 479435004680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435004681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435004683 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435004684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004685 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 479435004686 substrate binding site [chemical binding]; other site 479435004687 catalytic residues [active] 479435004688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004689 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 479435004690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004691 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435004692 putative NAD(P) binding site [chemical binding]; other site 479435004693 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 479435004694 conserved cys residue [active] 479435004695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004697 active site 479435004698 phosphorylation site [posttranslational modification] 479435004699 intermolecular recognition site; other site 479435004700 dimerization interface [polypeptide binding]; other site 479435004701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435004702 DNA binding residues [nucleotide binding] 479435004703 dimerization interface [polypeptide binding]; other site 479435004704 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004705 Berberine and berberine like; Region: BBE; pfam08031 479435004706 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435004707 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435004708 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435004709 Predicted ATPase [General function prediction only]; Region: COG3899 479435004710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435004712 DNA binding residues [nucleotide binding] 479435004713 dimerization interface [polypeptide binding]; other site 479435004714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435004716 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435004717 putative NAD(P) binding site [chemical binding]; other site 479435004718 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435004719 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435004720 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435004721 active site 479435004722 metal binding site [ion binding]; metal-binding site 479435004723 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479435004724 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435004725 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435004726 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 479435004727 active site 479435004728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004729 Uncharacterized conserved protein [Function unknown]; Region: COG5276 479435004730 short chain dehydrogenase; Provisional; Region: PRK06924 479435004731 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435004732 NADP binding site [chemical binding]; other site 479435004733 active site 479435004734 steroid binding site; other site 479435004735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004736 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 479435004737 active site 479435004738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004741 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435004742 NAD(P) binding site [chemical binding]; other site 479435004743 active site 479435004744 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435004745 GAF domain; Region: GAF; cl00853 479435004746 ANTAR domain; Region: ANTAR; cl04297 479435004747 Phosphotransferase enzyme family; Region: APH; pfam01636 479435004748 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435004749 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435004750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435004752 DNA binding residues [nucleotide binding] 479435004753 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435004754 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435004755 homotrimer interaction site [polypeptide binding]; other site 479435004756 putative active site [active] 479435004757 Cupin domain; Region: Cupin_2; cl09118 479435004758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435004759 LysE type translocator; Region: LysE; cl00565 479435004760 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 479435004761 Calx-beta domain; Region: Calx-beta; cl02522 479435004762 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 479435004763 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 479435004764 ATP binding site [chemical binding]; other site 479435004765 active site 479435004766 substrate binding site [chemical binding]; other site 479435004767 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435004768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004769 DNA-binding site [nucleotide binding]; DNA binding site 479435004770 UTRA domain; Region: UTRA; cl01230 479435004771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004772 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479435004773 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435004774 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004775 Phage integrase family; Region: Phage_integrase; pfam00589 479435004776 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435004777 DNA binding site [nucleotide binding] 479435004778 Int/Topo IB signature motif; other site 479435004779 active site 479435004780 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435004781 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 479435004782 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 479435004783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004785 DNA binding site [nucleotide binding] 479435004786 domain linker motif; other site 479435004787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004788 dimerization interface [polypeptide binding]; other site 479435004789 ligand binding site [chemical binding]; other site 479435004790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004791 dimer interface [polypeptide binding]; other site 479435004792 conserved gate region; other site 479435004793 putative PBP binding loops; other site 479435004794 ABC-ATPase subunit interface; other site 479435004795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004797 dimer interface [polypeptide binding]; other site 479435004798 conserved gate region; other site 479435004799 putative PBP binding loops; other site 479435004800 ABC-ATPase subunit interface; other site 479435004801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004804 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435004805 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 479435004806 putative active site [active] 479435004807 putative substrate binding site [chemical binding]; other site 479435004808 catalytic site [active] 479435004809 dimer interface [polypeptide binding]; other site 479435004810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435004811 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479435004812 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 479435004813 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435004814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004815 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435004816 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435004817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435004818 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 479435004819 DNA-binding site [nucleotide binding]; DNA binding site 479435004820 RNA-binding motif; other site 479435004821 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 479435004822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004823 Walker A/P-loop; other site 479435004824 ATP binding site [chemical binding]; other site 479435004825 Q-loop/lid; other site 479435004826 ABC transporter signature motif; other site 479435004827 Walker B; other site 479435004828 D-loop; other site 479435004829 H-loop/switch region; other site 479435004830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435004832 active site 479435004833 phosphorylation site [posttranslational modification] 479435004834 intermolecular recognition site; other site 479435004835 dimerization interface [polypeptide binding]; other site 479435004836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435004837 DNA binding residues [nucleotide binding] 479435004838 dimerization interface [polypeptide binding]; other site 479435004839 Histidine kinase; Region: HisKA_3; pfam07730 479435004840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435004841 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 479435004842 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 479435004843 GTP binding site [chemical binding]; other site 479435004844 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 479435004845 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 479435004846 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 479435004847 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 479435004848 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435004849 catalytic loop [active] 479435004850 iron binding site [ion binding]; other site 479435004851 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 479435004852 [4Fe-4S] binding site [ion binding]; other site 479435004853 molybdopterin cofactor binding site; other site 479435004854 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_CT_Formate-Dh_H; cd02790 479435004855 molybdopterin cofactor binding site; other site 479435004856 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435004857 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 479435004858 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 479435004859 SLBB domain; Region: SLBB; pfam10531 479435004860 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 479435004861 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479435004862 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435004863 dimer interface [polypeptide binding]; other site 479435004864 putative functional site; other site 479435004865 putative MPT binding site; other site 479435004866 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 479435004867 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435004868 dimer interface [polypeptide binding]; other site 479435004869 putative functional site; other site 479435004870 putative MPT binding site; other site 479435004871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004872 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 479435004873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435004875 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435004876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004877 Walker A/P-loop; other site 479435004878 ATP binding site [chemical binding]; other site 479435004879 Q-loop/lid; other site 479435004880 ABC transporter signature motif; other site 479435004881 Walker B; other site 479435004882 D-loop; other site 479435004883 H-loop/switch region; other site 479435004884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 479435004885 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 479435004886 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 479435004887 glyoxylate carboligase; Provisional; Region: PRK11269 479435004888 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435004889 PYR/PP interface [polypeptide binding]; other site 479435004890 dimer interface [polypeptide binding]; other site 479435004891 TPP binding site [chemical binding]; other site 479435004892 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435004893 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 479435004894 TPP-binding site [chemical binding]; other site 479435004895 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 479435004896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004897 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 479435004898 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435004899 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 479435004900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435004901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004902 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 479435004903 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435004904 putative sugar binding sites [chemical binding]; other site 479435004905 Q-X-W motif; other site 479435004906 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004908 dimer interface [polypeptide binding]; other site 479435004909 conserved gate region; other site 479435004910 putative PBP binding loops; other site 479435004911 ABC-ATPase subunit interface; other site 479435004912 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435004914 dimer interface [polypeptide binding]; other site 479435004915 conserved gate region; other site 479435004916 putative PBP binding loops; other site 479435004917 ABC-ATPase subunit interface; other site 479435004918 lac repressor; Reviewed; Region: lacI; PRK09526 479435004919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004920 DNA binding site [nucleotide binding] 479435004921 domain linker motif; other site 479435004922 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 479435004923 ligand binding site [chemical binding]; other site 479435004924 dimerization interface (open form) [polypeptide binding]; other site 479435004925 dimerization interface (closed form) [polypeptide binding]; other site 479435004926 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 479435004927 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 479435004928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004929 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 479435004930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004931 CoA-ligase; Region: Ligase_CoA; pfam00549 479435004932 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 479435004933 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435004934 CoA-ligase; Region: Ligase_CoA; pfam00549 479435004935 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 479435004936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004937 hypothetical protein; Provisional; Region: PRK05858 479435004938 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435004939 PYR/PP interface [polypeptide binding]; other site 479435004940 dimer interface [polypeptide binding]; other site 479435004941 TPP binding site [chemical binding]; other site 479435004942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435004943 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 479435004944 TPP-binding site; other site 479435004945 dimer interface [polypeptide binding]; other site 479435004946 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435004947 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 479435004948 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479435004949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004950 Integral membrane protein TerC family; Region: TerC; cl10468 479435004951 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435004952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004953 DNA-binding site [nucleotide binding]; DNA binding site 479435004954 FCD domain; Region: FCD; cl11656 479435004955 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 479435004956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435004958 dimerization interface [polypeptide binding]; other site 479435004959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004960 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 479435004961 putative active site [active] 479435004962 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435004963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435004964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435004965 S-adenosylmethionine binding site [chemical binding]; other site 479435004966 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435004967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435004968 DNA binding residues [nucleotide binding] 479435004969 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 479435004970 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 479435004971 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435004972 DNA binding residues [nucleotide binding] 479435004973 putative dimer interface [polypeptide binding]; other site 479435004974 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 479435004975 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 479435004976 Cupin domain; Region: Cupin_2; cl09118 479435004977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435004978 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 479435004979 homotrimer interaction site [polypeptide binding]; other site 479435004980 putative active site [active] 479435004981 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 479435004982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004983 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435004984 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 479435004985 SmpB-tmRNA interface; other site 479435004986 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435004987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435004988 DNA binding site [nucleotide binding] 479435004989 Int/Topo IB signature motif; other site 479435004990 active site 479435004991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004992 DNA-binding site [nucleotide binding]; DNA binding site 479435004993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435004994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004995 DNA-binding site [nucleotide binding]; DNA binding site 479435004996 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004997 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 479435004998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435004999 Walker A motif; other site 479435005000 ATP binding site [chemical binding]; other site 479435005001 Walker B motif; other site 479435005002 TrwC relaxase; Region: TrwC; cl08490 479435005003 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 479435005004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435005005 cofactor binding site; other site 479435005006 DNA binding site [nucleotide binding] 479435005007 substrate interaction site [chemical binding]; other site 479435005008 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435005009 polymerase nucleotide-binding site; other site 479435005010 DNA-binding residues [nucleotide binding]; DNA binding site 479435005011 nucleotide binding site [chemical binding]; other site 479435005012 primase nucleotide-binding site [nucleotide binding]; other site 479435005013 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 479435005014 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 479435005015 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 479435005016 G1 box; other site 479435005017 GTP/Mg2+ binding site [chemical binding]; other site 479435005018 Switch I region; other site 479435005019 G2 box; other site 479435005020 Switch II region; other site 479435005021 G3 box; other site 479435005022 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 479435005023 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 479435005024 G1 box; other site 479435005025 GTP/Mg2+ binding site [chemical binding]; other site 479435005026 Switch I region; other site 479435005027 G2 box; other site 479435005028 Switch II region; other site 479435005029 G3 box; other site 479435005030 G4 box; other site 479435005031 G5 box; other site 479435005032 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435005033 putative hydrophobic ligand binding site [chemical binding]; other site 479435005034 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479435005035 dimer interface [polypeptide binding]; other site 479435005036 ssDNA binding site [nucleotide binding]; other site 479435005037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435005038 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 479435005039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005040 Walker A/P-loop; other site 479435005041 ATP binding site [chemical binding]; other site 479435005042 Q-loop/lid; other site 479435005043 ABC transporter signature motif; other site 479435005044 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435005045 ABC transporter; Region: ABC_tran_2; pfam12848 479435005046 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435005047 Cupin domain; Region: Cupin_2; cl09118 479435005048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435005050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005052 NAD(P) binding site [chemical binding]; other site 479435005053 active site 479435005054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005055 YceI-like domain; Region: YceI; cl01001 479435005056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435005059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435005060 active site 479435005061 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 479435005062 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435005063 dimer interface [polypeptide binding]; other site 479435005064 active site 479435005065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435005066 classical (c) SDRs; Region: SDR_c; cd05233 479435005067 NAD(P) binding site [chemical binding]; other site 479435005068 active site 479435005069 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435005070 TIGR03086 family protein; Region: TIGR03086 479435005071 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435005072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005075 Walker A/P-loop; other site 479435005076 ATP binding site [chemical binding]; other site 479435005077 Q-loop/lid; other site 479435005078 ABC transporter signature motif; other site 479435005079 Walker B; other site 479435005080 D-loop; other site 479435005081 H-loop/switch region; other site 479435005082 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005083 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005084 Walker A/P-loop; other site 479435005085 ATP binding site [chemical binding]; other site 479435005086 Q-loop/lid; other site 479435005087 ABC transporter signature motif; other site 479435005088 Walker B; other site 479435005089 D-loop; other site 479435005090 H-loop/switch region; other site 479435005091 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435005092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005093 Coenzyme A binding pocket [chemical binding]; other site 479435005094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005095 Coenzyme A binding pocket [chemical binding]; other site 479435005096 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 479435005097 putative active site [active] 479435005098 putative catalytic site [active] 479435005099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005101 NAD(P) binding site [chemical binding]; other site 479435005102 active site 479435005103 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 479435005104 active site 479435005105 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 479435005106 active site 479435005107 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 479435005108 apolar tunnel; other site 479435005109 heme binding site [chemical binding]; other site 479435005110 dimerization interface [polypeptide binding]; other site 479435005111 OsmC-like protein; Region: OsmC; cl00767 479435005112 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 479435005113 Mechanosensitive ion channel; Region: MS_channel; pfam00924 479435005114 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 479435005115 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 479435005116 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 479435005117 Chitin binding domain; Region: Chitin_bind_3; cl03871 479435005118 Domain of unknown function (DUF477); Region: DUF477; cl01535 479435005119 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435005120 Beta-lactamase; Region: Beta-lactamase; cl01009 479435005121 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435005122 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435005123 Zn binding site [ion binding]; other site 479435005124 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 479435005125 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 479435005126 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435005127 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 479435005128 putative DNA binding site [nucleotide binding]; other site 479435005129 catalytic residue [active] 479435005130 putative H2TH interface [polypeptide binding]; other site 479435005131 putative catalytic residues [active] 479435005132 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435005133 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435005134 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 479435005135 active site 479435005136 putative catalytic site [active] 479435005137 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435005138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005139 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435005140 hydrophobic ligand binding site; other site 479435005141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005142 dimerization interface [polypeptide binding]; other site 479435005143 putative DNA binding site [nucleotide binding]; other site 479435005144 putative Zn2+ binding site [ion binding]; other site 479435005145 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435005146 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 479435005147 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435005148 Predicted ATPase [General function prediction only]; Region: COG4637 479435005149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435005152 putative dimerization interface [polypeptide binding]; other site 479435005153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005155 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 479435005156 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 479435005157 NADP binding site [chemical binding]; other site 479435005158 dimer interface [polypeptide binding]; other site 479435005159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005160 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435005161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005162 Walker A/P-loop; other site 479435005163 ATP binding site [chemical binding]; other site 479435005164 Q-loop/lid; other site 479435005165 ABC transporter signature motif; other site 479435005166 Walker B; other site 479435005167 D-loop; other site 479435005168 H-loop/switch region; other site 479435005169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005170 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435005171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005172 Walker A/P-loop; other site 479435005173 ATP binding site [chemical binding]; other site 479435005174 Q-loop/lid; other site 479435005175 ABC transporter signature motif; other site 479435005176 Walker B; other site 479435005177 D-loop; other site 479435005178 H-loop/switch region; other site 479435005179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435005180 S-adenosylmethionine binding site [chemical binding]; other site 479435005181 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 479435005182 nudix motif; other site 479435005183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435005184 S-adenosylmethionine binding site [chemical binding]; other site 479435005185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435005186 DinB superfamily; Region: DinB_2; cl00986 479435005187 YCII-related domain; Region: YCII; cl00999 479435005188 trigger factor; Provisional; Region: tig; PRK01490 479435005189 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 479435005190 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 479435005191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435005192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435005193 active site 479435005194 catalytic tetrad [active] 479435005195 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435005196 oligomer interface [polypeptide binding]; other site 479435005197 active site residues [active] 479435005198 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435005199 oligomer interface [polypeptide binding]; other site 479435005200 active site residues [active] 479435005201 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 479435005202 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 479435005203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435005204 Walker A motif; other site 479435005205 ATP binding site [chemical binding]; other site 479435005206 Walker B motif; other site 479435005207 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 479435005208 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435005209 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005210 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 479435005211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435005212 active site 479435005213 HIGH motif; other site 479435005214 nucleotide binding site [chemical binding]; other site 479435005215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435005216 active site 479435005217 KMSKS motif; other site 479435005218 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 479435005219 tRNA binding surface [nucleotide binding]; other site 479435005220 anticodon binding site; other site 479435005221 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 479435005222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435005223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435005224 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 479435005225 active site 479435005226 multimer interface [polypeptide binding]; other site 479435005227 MBOAT family; Region: MBOAT; cl00738 479435005228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005229 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435005230 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 479435005231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435005232 binding surface 479435005233 TPR motif; other site 479435005234 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435005235 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435005236 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435005237 RHS Repeat; Region: RHS_repeat; cl11982 479435005238 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435005239 rod shape-determining protein MreB; Provisional; Region: PRK13927 479435005240 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 479435005241 ATP binding site [chemical binding]; other site 479435005242 profilin binding site; other site 479435005243 Septum formation initiator; Region: DivIC; cl11433 479435005244 rod shape-determining protein MreC; Region: MreC; pfam04085 479435005245 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 479435005246 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435005247 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435005248 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 479435005249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005250 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435005251 homotrimer interaction site [polypeptide binding]; other site 479435005252 putative active site [active] 479435005253 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435005254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005255 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 479435005256 L-asparaginase II; Region: Asparaginase_II; cl01842 479435005257 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479435005258 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 479435005259 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 479435005260 B12 binding site [chemical binding]; other site 479435005261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435005262 FeS/SAM binding site; other site 479435005263 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 479435005264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435005265 active site 479435005266 motif I; other site 479435005267 motif II; other site 479435005268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005269 Coenzyme A binding pocket [chemical binding]; other site 479435005270 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435005271 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435005272 active site 479435005273 catalytic residues [active] 479435005274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005275 Coenzyme A binding pocket [chemical binding]; other site 479435005276 prephenate dehydratase; Provisional; Region: PRK11899 479435005277 Prephenate dehydratase; Region: PDT; pfam00800 479435005278 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 479435005279 putative L-Phe binding site [chemical binding]; other site 479435005280 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435005281 putative acyl-acceptor binding pocket; other site 479435005282 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 479435005283 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 479435005284 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 479435005285 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 479435005286 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 479435005287 homodimer interface [polypeptide binding]; other site 479435005288 oligonucleotide binding site [chemical binding]; other site 479435005289 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 479435005290 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 479435005291 GTPase CgtA; Reviewed; Region: obgE; PRK12296 479435005292 GTP1/OBG; Region: GTP1_OBG; pfam01018 479435005293 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 479435005294 G1 box; other site 479435005295 GTP/Mg2+ binding site [chemical binding]; other site 479435005296 Switch I region; other site 479435005297 G2 box; other site 479435005298 G3 box; other site 479435005299 Switch II region; other site 479435005300 G4 box; other site 479435005301 G5 box; other site 479435005302 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 479435005303 gamma-glutamyl kinase; Provisional; Region: PRK05429 479435005304 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 479435005305 nucleotide binding site [chemical binding]; other site 479435005306 homotetrameric interface [polypeptide binding]; other site 479435005307 putative phosphate binding site [ion binding]; other site 479435005308 putative allosteric binding site; other site 479435005309 PUA domain; Region: PUA; cl00607 479435005310 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 479435005311 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 479435005312 putative catalytic cysteine [active] 479435005313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005314 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435005315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435005317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005318 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 479435005319 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 479435005320 active site 479435005321 (T/H)XGH motif; other site 479435005322 Domain of unknown function DUF143; Region: DUF143; cl00519 479435005323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435005324 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435005325 catalytic core [active] 479435005326 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005328 Walker A/P-loop; other site 479435005329 ATP binding site [chemical binding]; other site 479435005330 Q-loop/lid; other site 479435005331 ABC transporter signature motif; other site 479435005332 Walker B; other site 479435005333 D-loop; other site 479435005334 H-loop/switch region; other site 479435005335 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435005336 Histidine kinase; Region: HisKA_3; pfam07730 479435005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435005338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435005340 active site 479435005341 phosphorylation site [posttranslational modification] 479435005342 intermolecular recognition site; other site 479435005343 dimerization interface [polypeptide binding]; other site 479435005344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435005345 DNA binding residues [nucleotide binding] 479435005346 dimerization interface [polypeptide binding]; other site 479435005347 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435005348 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435005349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005350 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435005352 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479435005353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435005354 substrate binding pocket [chemical binding]; other site 479435005355 membrane-bound complex binding site; other site 479435005356 hinge residues; other site 479435005357 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435005358 putative catalytic site [active] 479435005359 putative metal binding site [ion binding]; other site 479435005360 putative phosphate binding site [ion binding]; other site 479435005361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435005362 S-adenosylmethionine binding site [chemical binding]; other site 479435005363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435005364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005365 classical (c) SDRs; Region: SDR_c; cd05233 479435005366 NAD(P) binding site [chemical binding]; other site 479435005367 active site 479435005368 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435005369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005370 Coenzyme A binding pocket [chemical binding]; other site 479435005371 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435005372 Phosphotransferase enzyme family; Region: APH; pfam01636 479435005373 active site 479435005374 ATP binding site [chemical binding]; other site 479435005375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435005376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005378 DNA binding site [nucleotide binding] 479435005379 domain linker motif; other site 479435005380 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435005381 dimerization interface [polypeptide binding]; other site 479435005382 ligand binding site [chemical binding]; other site 479435005383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435005384 conserved cys residue [active] 479435005385 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005387 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435005388 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479435005389 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435005390 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435005391 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435005392 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 479435005393 siderophore binding site; other site 479435005394 BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur...; Region: BAH; cl02608 479435005395 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435005396 putative catalytic site [active] 479435005397 putative metal binding site [ion binding]; other site 479435005398 putative phosphate binding site [ion binding]; other site 479435005399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435005401 active site 479435005402 phosphorylation site [posttranslational modification] 479435005403 intermolecular recognition site; other site 479435005404 dimerization interface [polypeptide binding]; other site 479435005405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435005406 DNA binding residues [nucleotide binding] 479435005407 dimerization interface [polypeptide binding]; other site 479435005408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435005409 Histidine kinase; Region: HisKA_3; pfam07730 479435005410 Sodium:solute symporter family; Region: SSF; cl00456 479435005411 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435005412 Cupin domain; Region: Cupin_2; cl09118 479435005413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435005414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005415 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 479435005416 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 479435005417 HIGH motif; other site 479435005418 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435005419 active site 479435005420 KMSKS motif; other site 479435005421 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 479435005422 tRNA binding surface [nucleotide binding]; other site 479435005423 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 479435005424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435005425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005426 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435005427 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 479435005428 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 479435005429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435005430 Competence protein; Region: Competence; cl00471 479435005431 Competence protein; Region: Competence; cl00471 479435005432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435005433 hypothetical protein; Reviewed; Region: PRK07914 479435005434 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 479435005435 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 479435005436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005438 DNA binding site [nucleotide binding] 479435005439 domain linker motif; other site 479435005440 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435005441 dimerization interface [polypeptide binding]; other site 479435005442 ligand binding site [chemical binding]; other site 479435005443 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435005444 putative sugar binding sites [chemical binding]; other site 479435005445 Q-X-W motif; other site 479435005446 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435005447 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 479435005448 active site 479435005449 catalytic triad [active] 479435005450 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease...; Region: PA_subtilisin_like; cd02120 479435005451 PA/protease or protease-like domain interface [polypeptide binding]; other site 479435005452 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435005453 catalytic residues [active] 479435005454 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435005455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435005456 DNA binding residues [nucleotide binding] 479435005457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435005458 active site 479435005459 substrate binding site [chemical binding]; other site 479435005460 ATP binding site [chemical binding]; other site 479435005461 GTP-binding protein LepA; Provisional; Region: PRK05433 479435005462 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 479435005463 G1 box; other site 479435005464 putative GEF interaction site [polypeptide binding]; other site 479435005465 GTP/Mg2+ binding site [chemical binding]; other site 479435005466 Switch I region; other site 479435005467 G2 box; other site 479435005468 G3 box; other site 479435005469 Switch II region; other site 479435005470 G4 box; other site 479435005471 G5 box; other site 479435005472 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 479435005473 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 479435005474 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 479435005475 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435005476 MOSC domain; Region: MOSC; pfam03473 479435005477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435005478 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 479435005479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005480 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435005481 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 479435005482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005483 NAD(P) binding site [chemical binding]; other site 479435005484 active site 479435005485 KduI/IolB family; Region: KduI; cl01508 479435005486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435005487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435005488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435005489 dimer interface [polypeptide binding]; other site 479435005490 conserved gate region; other site 479435005491 putative PBP binding loops; other site 479435005492 ABC-ATPase subunit interface; other site 479435005493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435005494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435005495 dimer interface [polypeptide binding]; other site 479435005496 conserved gate region; other site 479435005497 putative PBP binding loops; other site 479435005498 ABC-ATPase subunit interface; other site 479435005499 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435005500 metal binding site [ion binding]; metal-binding site 479435005501 substrate binding pocket [chemical binding]; other site 479435005502 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 479435005503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005504 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 479435005505 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 479435005506 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435005507 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435005508 Transglycosylase; Region: Transgly; cl07896 479435005509 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 479435005510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435005511 coproporphyrinogen III oxidase; Validated; Region: PRK05628 479435005512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435005513 FeS/SAM binding site; other site 479435005514 HemN C-terminal region; Region: HemN_C; pfam06969 479435005515 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435005516 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005518 DNA binding site [nucleotide binding] 479435005519 domain linker motif; other site 479435005520 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435005521 putative dimerization interface [polypeptide binding]; other site 479435005522 putative ligand binding site [chemical binding]; other site 479435005523 patatin-related protein; Region: TIGR03607 479435005524 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 479435005525 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 479435005526 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 479435005527 putative active site [active] 479435005528 Sodium:solute symporter family; Region: SSF; cl00456 479435005529 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 479435005530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435005531 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435005532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005533 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005534 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 479435005535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005536 HrcA protein C terminal domain; Region: HrcA; pfam01628 479435005537 chaperone protein DnaJ; Provisional; Region: PRK14278 479435005538 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 479435005539 HSP70 interaction site [polypeptide binding]; other site 479435005540 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 479435005541 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 479435005542 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 479435005543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435005544 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 479435005545 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435005546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435005547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435005548 DNA binding residues [nucleotide binding] 479435005549 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 479435005550 PhoH-like protein; Region: PhoH; cl12134 479435005551 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 479435005552 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435005553 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435005554 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435005555 Transporter associated domain; Region: CorC_HlyC; cl08393 479435005556 GTPase Era; Reviewed; Region: era; PRK00089 479435005557 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 479435005558 G1 box; other site 479435005559 GTP/Mg2+ binding site [chemical binding]; other site 479435005560 Switch I region; other site 479435005561 G2 box; other site 479435005562 Switch II region; other site 479435005563 G3 box; other site 479435005564 G4 box; other site 479435005565 G5 box; other site 479435005566 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 479435005567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435005568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005569 classical (c) SDRs; Region: SDR_c; cd05233 479435005570 NAD(P) binding site [chemical binding]; other site 479435005571 active site 479435005572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005574 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435005575 metal binding site 2 [ion binding]; metal-binding site 479435005576 putative DNA binding helix; other site 479435005577 metal binding site 1 [ion binding]; metal-binding site 479435005578 dimer interface [polypeptide binding]; other site 479435005579 structural Zn2+ binding site [ion binding]; other site 479435005580 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 479435005581 dimer interface [polypeptide binding]; other site 479435005582 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 479435005583 active site 479435005584 heme binding site [chemical binding]; other site 479435005585 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 479435005586 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435005587 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 479435005588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005590 2-isopropylmalate synthase; Validated; Region: PRK03739 479435005591 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 479435005592 active site 479435005593 catalytic residues [active] 479435005594 metal binding site [ion binding]; metal-binding site 479435005595 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 479435005596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435005597 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435005598 nudix motif; other site 479435005599 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435005600 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435005601 Walker A/P-loop; other site 479435005602 ATP binding site [chemical binding]; other site 479435005603 Q-loop/lid; other site 479435005604 ABC transporter signature motif; other site 479435005605 Walker B; other site 479435005606 D-loop; other site 479435005607 H-loop/switch region; other site 479435005608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435005609 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435005610 Walker A/P-loop; other site 479435005611 ATP binding site [chemical binding]; other site 479435005612 Q-loop/lid; other site 479435005613 ABC transporter signature motif; other site 479435005614 Walker B; other site 479435005615 D-loop; other site 479435005616 H-loop/switch region; other site 479435005617 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435005618 OsmC-like protein; Region: OsmC; cl00767 479435005619 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435005620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435005621 active site 479435005622 catalytic tetrad [active] 479435005623 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 479435005624 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435005625 NADP binding site [chemical binding]; other site 479435005626 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435005627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435005628 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 479435005629 Recombination protein O N terminal; Region: RecO_N; pfam11967 479435005630 Recombination protein O C terminal; Region: RecO_C; pfam02565 479435005631 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 479435005632 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 479435005633 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 479435005634 catalytic residue [active] 479435005635 putative FPP diphosphate binding site; other site 479435005636 putative FPP binding hydrophobic cleft; other site 479435005637 dimer interface [polypeptide binding]; other site 479435005638 putative IPP diphosphate binding site; other site 479435005639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435005640 active site 479435005641 phosphorylation site [posttranslational modification] 479435005642 intermolecular recognition site; other site 479435005643 dimerization interface [polypeptide binding]; other site 479435005644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435005645 DNA binding residues [nucleotide binding] 479435005646 dimerization interface [polypeptide binding]; other site 479435005647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435005648 Histidine kinase; Region: HisKA_3; pfam07730 479435005649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435005650 ATP binding site [chemical binding]; other site 479435005651 Mg2+ binding site [ion binding]; other site 479435005652 G-X-G motif; other site 479435005653 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435005654 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005655 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 479435005656 Walker A/P-loop; other site 479435005657 ATP binding site [chemical binding]; other site 479435005658 Q-loop/lid; other site 479435005659 ABC transporter signature motif; other site 479435005660 Walker B; other site 479435005661 D-loop; other site 479435005662 H-loop/switch region; other site 479435005663 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 479435005664 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 479435005665 NAD binding site [chemical binding]; other site 479435005666 catalytic Zn binding site [ion binding]; other site 479435005667 substrate binding site [chemical binding]; other site 479435005668 structural Zn binding site [ion binding]; other site 479435005669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435005670 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435005671 metal binding site 2 [ion binding]; metal-binding site 479435005672 putative DNA binding helix; other site 479435005673 metal binding site 1 [ion binding]; metal-binding site 479435005674 dimer interface [polypeptide binding]; other site 479435005675 structural Zn2+ binding site [ion binding]; other site 479435005676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435005677 ABC-ATPase subunit interface; other site 479435005678 dimer interface [polypeptide binding]; other site 479435005679 putative PBP binding regions; other site 479435005680 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 479435005681 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 479435005682 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435005683 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 479435005684 intersubunit interface [polypeptide binding]; other site 479435005685 YibE/F-like protein; Region: YibE_F; cl02259 479435005686 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435005687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005689 DNA binding site [nucleotide binding] 479435005690 domain linker motif; other site 479435005691 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435005692 putative dimerization interface [polypeptide binding]; other site 479435005693 putative ligand binding site [chemical binding]; other site 479435005694 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435005695 sugar binding site [chemical binding]; other site 479435005696 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435005697 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 479435005698 active site 479435005699 catalytic residues [active] 479435005700 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435005701 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 479435005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 479435005703 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435005704 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435005705 active site 479435005706 ATP binding site [chemical binding]; other site 479435005707 substrate binding site [chemical binding]; other site 479435005708 activation loop (A-loop); other site 479435005709 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 479435005710 active site 479435005711 zinc binding site [ion binding]; other site 479435005712 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435005713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005715 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435005716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005717 Q-loop/lid; other site 479435005718 ABC transporter signature motif; other site 479435005719 Walker B; other site 479435005720 D-loop; other site 479435005721 H-loop/switch region; other site 479435005722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005724 Walker A/P-loop; other site 479435005725 ATP binding site [chemical binding]; other site 479435005726 Q-loop/lid; other site 479435005727 ABC transporter signature motif; other site 479435005728 Walker B; other site 479435005729 D-loop; other site 479435005730 H-loop/switch region; other site 479435005731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435005733 DNA binding residues [nucleotide binding] 479435005734 dimerization interface [polypeptide binding]; other site 479435005735 hypothetical protein; Provisional; Region: PRK07588 479435005736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005739 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 479435005740 glycyl-tRNA synthetase; Provisional; Region: PRK04173 479435005741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435005742 motif 1; other site 479435005743 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 479435005744 motif 1; other site 479435005745 dimer interface [polypeptide binding]; other site 479435005746 active site 479435005747 motif 2; other site 479435005748 motif 3; other site 479435005749 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 479435005750 anticodon binding site; other site 479435005751 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 479435005752 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 479435005753 FMN binding site [chemical binding]; other site 479435005754 active site 479435005755 catalytic residues [active] 479435005756 substrate binding site [chemical binding]; other site 479435005757 Uncharacterized conserved protein [Function unknown]; Region: COG3342 479435005758 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 479435005759 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479435005760 nucleotide binding site [chemical binding]; other site 479435005761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435005762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005764 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435005765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005767 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005768 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 479435005769 active site 479435005770 SUMO-1 interface [polypeptide binding]; other site 479435005771 Clp amino terminal domain; Region: Clp_N; pfam02861 479435005772 Clp amino terminal domain; Region: Clp_N; pfam02861 479435005773 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435005774 Beta-lactamase; Region: Beta-lactamase; cl01009 479435005775 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 479435005776 DNA binding residues [nucleotide binding] 479435005777 putative dimer interface [polypeptide binding]; other site 479435005778 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 479435005779 DNA binding residues [nucleotide binding] 479435005780 putative dimer interface [polypeptide binding]; other site 479435005781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435005782 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 479435005783 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435005784 pyruvate phosphate dikinase; Provisional; Region: PRK09279 479435005785 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479435005786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 479435005787 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435005788 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435005789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005790 NAD(P) binding site [chemical binding]; other site 479435005791 active site 479435005792 YCII-related domain; Region: YCII; cl00999 479435005793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005794 non-specific DNA binding site [nucleotide binding]; other site 479435005795 salt bridge; other site 479435005796 sequence-specific DNA binding site [nucleotide binding]; other site 479435005797 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 479435005798 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 479435005799 putative active site [active] 479435005800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005802 TIGR03086 family protein; Region: TIGR03086 479435005803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005804 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435005805 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435005806 FAD binding domain; Region: FAD_binding_4; pfam01565 479435005807 Berberine and berberine like; Region: BBE; pfam08031 479435005808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435005809 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435005810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005811 DNA-binding site [nucleotide binding]; DNA binding site 479435005812 FCD domain; Region: FCD; cl11656 479435005813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005815 DNA primase; Validated; Region: dnaG; PRK05667 479435005816 CHC2 zinc finger; Region: zf-CHC2; cl02597 479435005817 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 479435005818 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 479435005819 active site 479435005820 metal binding site [ion binding]; metal-binding site 479435005821 interdomain interaction site; other site 479435005822 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 479435005823 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 479435005824 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 479435005825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435005826 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435005827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435005828 D-cysteine desulfhydrase; Validated; Region: PRK03910 479435005829 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 479435005830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435005831 catalytic residue [active] 479435005832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005833 DNA-binding site [nucleotide binding]; DNA binding site 479435005834 FCD domain; Region: FCD; cl11656 479435005835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005837 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005838 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 479435005839 active site 479435005840 Isochorismatase family; Region: Isochorismatase; pfam00857 479435005841 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435005842 catalytic triad [active] 479435005843 conserved cis-peptide bond; other site 479435005844 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435005845 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435005846 conserved cys residue [active] 479435005847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005848 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 479435005849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005850 NAD(P) binding site [chemical binding]; other site 479435005851 active site 479435005852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005853 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435005854 Uncharacterized conserved protein [Function unknown]; Region: COG4997 479435005855 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435005856 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435005857 active site 479435005858 NTP binding site [chemical binding]; other site 479435005859 metal binding triad [ion binding]; metal-binding site 479435005860 antibiotic binding site [chemical binding]; other site 479435005861 argininosuccinate synthase; Region: argG; TIGR00032 479435005862 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 479435005863 Ligand Binding Site [chemical binding]; other site 479435005864 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435005865 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 479435005866 putative phosphate binding site [ion binding]; other site 479435005867 putative catalytic site [active] 479435005868 active site 479435005869 metal binding site A [ion binding]; metal-binding site 479435005870 DNA binding site [nucleotide binding] 479435005871 putative AP binding site [nucleotide binding]; other site 479435005872 putative metal binding site B [ion binding]; other site 479435005873 DinB superfamily; Region: DinB_2; cl00986 479435005874 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435005875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435005876 active site 479435005877 catalytic tetrad [active] 479435005878 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 479435005879 Active site serine [active] 479435005880 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 479435005881 Sulfate transporter family; Region: Sulfate_transp; cl00967 479435005882 Sulfate transporter family; Region: Sulfate_transp; cl00967 479435005883 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 479435005884 active site clefts [active] 479435005885 zinc binding site [ion binding]; other site 479435005886 dimer interface [polypeptide binding]; other site 479435005887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005889 NAD(P) binding site [chemical binding]; other site 479435005890 active site 479435005891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435005892 DNA binding residues [nucleotide binding] 479435005893 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 479435005894 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435005895 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435005896 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 479435005897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435005898 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435005899 putative substrate translocation pore; other site 479435005900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435005902 dimerization interface [polypeptide binding]; other site 479435005903 UbiA prenyltransferase family; Region: UbiA; cl00337 479435005904 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 479435005905 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 479435005906 malonyl-CoA binding site [chemical binding]; other site 479435005907 dimer interface [polypeptide binding]; other site 479435005908 active site 479435005909 product binding site; other site 479435005910 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 479435005911 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 479435005912 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 479435005913 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435005914 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435005915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435005916 catalytic residues [active] 479435005917 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435005918 catalytic tetrad [active] 479435005919 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 479435005920 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 479435005921 AAA-like domain; Region: AAA_10; pfam12846 479435005922 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 479435005923 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435005924 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435005925 Aerotolerance regulator N-terminal; Region: BatA; cl06567 479435005926 hypothetical protein; Provisional; Region: PRK13685 479435005927 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435005928 metal ion-dependent adhesion site (MIDAS); other site 479435005929 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 479435005930 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435005931 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435005932 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 479435005933 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435005934 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 479435005935 dimer interface [polypeptide binding]; other site 479435005936 active site 479435005937 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435005938 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 479435005939 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 479435005940 dimer interface [polypeptide binding]; other site 479435005941 active site 479435005942 CoA binding pocket [chemical binding]; other site 479435005943 Acyl transferase domain; Region: Acyl_transf_1; cl08282 479435005944 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479435005945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 479435005946 carboxyltransferase (CT) interaction site; other site 479435005947 biotinylation site [posttranslational modification]; other site 479435005948 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 479435005949 hypothetical protein; Provisional; Region: PRK07945 479435005950 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 479435005951 metal binding triad [ion binding]; metal-binding site 479435005952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435005953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435005954 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 479435005955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435005956 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 479435005957 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 479435005958 dimer interface [polypeptide binding]; other site 479435005959 TPP-binding site [chemical binding]; other site 479435005960 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479435005961 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 479435005962 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 479435005963 dimer interface [polypeptide binding]; other site 479435005964 catalytic triad [active] 479435005965 acyl-CoA synthetase; Validated; Region: PRK09192 479435005966 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435005967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479435005968 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435005969 active site 479435005970 Acyl transferase domain; Region: Acyl_transf_1; cl08282 479435005971 peptide synthase; Provisional; Region: PRK12467 479435005972 Condensation domain; Region: Condensation; cl09290 479435005973 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435005974 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435005975 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435005976 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 479435005977 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 479435005978 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 479435005979 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 479435005980 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 479435005981 PhoD-like phosphatase; Region: PhoD; pfam09423 479435005982 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435005983 putative active site [active] 479435005984 putative metal binding site [ion binding]; other site 479435005985 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435005986 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435005987 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 479435005988 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435005989 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435005990 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 479435005991 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 479435005992 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 479435005993 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 479435005994 Putative zinc ribbon domain; Region: DUF164; pfam02591 479435005995 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 479435005996 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 479435005997 RNA/DNA hybrid binding site [nucleotide binding]; other site 479435005998 active site 479435005999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435006000 catalytic core [active] 479435006001 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 479435006002 RNB domain; Region: RNB; pfam00773 479435006003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 479435006004 RNA binding site [nucleotide binding]; other site 479435006005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006007 Coenzyme A binding pocket [chemical binding]; other site 479435006008 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435006009 Cupin domain; Region: Cupin_2; cl09118 479435006010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435006011 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435006012 Protein of unknown function (DUF952); Region: DUF952; cl01393 479435006013 PhoD-like phosphatase; Region: PhoD; pfam09423 479435006014 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006015 putative active site [active] 479435006016 putative metal binding site [ion binding]; other site 479435006017 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006018 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 479435006019 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 479435006020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006021 Coenzyme A binding pocket [chemical binding]; other site 479435006022 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435006023 methionine aminopeptidase; Reviewed; Region: PRK07281 479435006024 active site 479435006025 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435006026 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435006027 intersubunit interface [polypeptide binding]; other site 479435006028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435006029 nudix motif; other site 479435006030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435006031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435006032 active site 479435006033 catalytic tetrad [active] 479435006034 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 479435006035 oligomerization interface [polypeptide binding]; other site 479435006036 active site 479435006037 metal binding site [ion binding]; metal-binding site 479435006038 NAD synthetase; Provisional; Region: PRK13981 479435006039 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 479435006040 multimer interface [polypeptide binding]; other site 479435006041 active site 479435006042 catalytic triad [active] 479435006043 protein interface 1 [polypeptide binding]; other site 479435006044 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 479435006045 homodimer interface [polypeptide binding]; other site 479435006046 NAD binding pocket [chemical binding]; other site 479435006047 ATP binding pocket [chemical binding]; other site 479435006048 Mg binding site [ion binding]; other site 479435006049 active-site loop [active] 479435006050 Predicted membrane protein [Function unknown]; Region: COG2311 479435006051 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435006052 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435006053 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435006054 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 479435006055 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479435006056 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435006057 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435006058 HupE / UreJ protein; Region: HupE_UreJ; cl01011 479435006059 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435006060 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 479435006061 active site 479435006062 metal binding site [ion binding]; metal-binding site 479435006063 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435006064 active site 479435006065 metal binding site [ion binding]; metal-binding site 479435006066 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 479435006067 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 479435006068 Trp docking motif; other site 479435006069 'Velcro' closure; other site 479435006070 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 479435006071 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435006072 metal binding triad; other site 479435006073 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435006074 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435006075 metal binding triad; other site 479435006076 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435006077 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435006078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435006080 DNA binding residues [nucleotide binding] 479435006081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435006082 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435006083 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 479435006084 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 479435006085 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435006086 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 479435006087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435006088 Walker A/P-loop; other site 479435006089 ATP binding site [chemical binding]; other site 479435006090 Q-loop/lid; other site 479435006091 ABC transporter signature motif; other site 479435006092 Walker B; other site 479435006093 D-loop; other site 479435006094 H-loop/switch region; other site 479435006095 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435006096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435006097 dimer interface [polypeptide binding]; other site 479435006098 conserved gate region; other site 479435006099 putative PBP binding loops; other site 479435006100 ABC-ATPase subunit interface; other site 479435006101 Transcription factor WhiB; Region: Whib; pfam02467 479435006102 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 479435006103 DNA binding residues [nucleotide binding] 479435006104 CrcB-like protein; Region: CRCB; cl09114 479435006105 CrcB-like protein; Region: CRCB; cl09114 479435006106 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435006107 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435006108 catalytic core [active] 479435006109 NeuB family; Region: NeuB; cl00496 479435006110 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 479435006111 Pseudomonas-type; Region: PC_PLC; TIGR03396 479435006112 Sulfatase; Region: Sulfatase; cl10460 479435006113 Domain of unknown function (DUF756); Region: DUF756; pfam05506 479435006114 Domain of unknown function (DUF756); Region: DUF756; pfam05506 479435006115 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 479435006116 putative deacylase active site [active] 479435006117 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435006118 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 479435006119 GTP cyclohydrolase I; Provisional; Region: PLN03044 479435006120 active site 479435006121 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 479435006122 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 479435006123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435006124 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 479435006125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006126 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 479435006127 active site 479435006128 metal binding site [ion binding]; metal-binding site 479435006129 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435006130 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435006131 DNA binding residues [nucleotide binding] 479435006132 dimer interface [polypeptide binding]; other site 479435006133 mercury binding site [ion binding]; other site 479435006134 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 479435006135 substrate binding site [chemical binding]; other site 479435006136 ATP binding site [chemical binding]; other site 479435006137 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 479435006138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435006139 S-adenosylmethionine binding site [chemical binding]; other site 479435006140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006141 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 479435006142 Walker A/P-loop; other site 479435006143 ATP binding site [chemical binding]; other site 479435006144 Q-loop/lid; other site 479435006145 ABC transporter signature motif; other site 479435006146 Walker B; other site 479435006147 D-loop; other site 479435006148 H-loop/switch region; other site 479435006149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006150 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 479435006151 PhoD-like phosphatase; Region: PhoD; pfam09423 479435006152 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006153 putative active site [active] 479435006154 putative metal binding site [ion binding]; other site 479435006155 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 479435006156 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435006157 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479435006158 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 479435006159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435006160 non-specific DNA binding site [nucleotide binding]; other site 479435006161 salt bridge; other site 479435006162 sequence-specific DNA binding site [nucleotide binding]; other site 479435006163 glutamine synthetase, type I; Region: GlnA; TIGR00653 479435006164 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435006165 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435006166 RDD family; Region: RDD; cl00746 479435006167 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 479435006168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435006169 S-adenosylmethionine binding site [chemical binding]; other site 479435006170 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 479435006171 dimer interface [polypeptide binding]; other site 479435006172 ligand binding site [chemical binding]; other site 479435006173 lipoyl synthase; Provisional; Region: PRK05481 479435006174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435006175 FeS/SAM binding site; other site 479435006176 Histidine kinase; Region: HisKA_3; pfam07730 479435006177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435006178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435006179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435006180 active site 479435006181 phosphorylation site [posttranslational modification] 479435006182 intermolecular recognition site; other site 479435006183 dimerization interface [polypeptide binding]; other site 479435006184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435006185 DNA binding residues [nucleotide binding] 479435006186 dimerization interface [polypeptide binding]; other site 479435006187 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435006188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006190 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 479435006191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006192 Walker A/P-loop; other site 479435006193 ATP binding site [chemical binding]; other site 479435006194 Q-loop/lid; other site 479435006195 ABC transporter signature motif; other site 479435006196 Walker B; other site 479435006197 D-loop; other site 479435006198 H-loop/switch region; other site 479435006199 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 479435006200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435006201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006202 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435006203 putative dimerization interface [polypeptide binding]; other site 479435006204 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 479435006205 ribonuclease E; Reviewed; Region: rne; PRK10811 479435006206 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 479435006207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435006208 active site 479435006209 ATP binding site [chemical binding]; other site 479435006210 substrate binding site [chemical binding]; other site 479435006211 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 479435006212 active site 479435006213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006214 TIGR01777 family protein; Region: yfcH 479435006215 NAD(P) binding site [chemical binding]; other site 479435006216 active site 479435006217 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435006218 E3 interaction surface; other site 479435006219 lipoyl attachment site [posttranslational modification]; other site 479435006220 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435006221 E3 interaction surface; other site 479435006222 lipoyl attachment site [posttranslational modification]; other site 479435006223 e3 binding domain; Region: E3_binding; pfam02817 479435006224 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 479435006225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 479435006226 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 479435006227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435006229 multifunctional aminopeptidase A; Provisional; Region: PRK00913 479435006230 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 479435006231 interface (dimer of trimers) [polypeptide binding]; other site 479435006232 Substrate-binding/catalytic site; other site 479435006233 Zn-binding sites [ion binding]; other site 479435006234 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 479435006235 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479435006236 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 479435006237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006238 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435006239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435006241 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435006242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435006243 dimer interface [polypeptide binding]; other site 479435006244 conserved gate region; other site 479435006245 putative PBP binding loops; other site 479435006246 ABC-ATPase subunit interface; other site 479435006247 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 479435006248 peptide binding site [polypeptide binding]; other site 479435006249 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435006250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435006251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435006252 dimer interface [polypeptide binding]; other site 479435006253 conserved gate region; other site 479435006254 putative PBP binding loops; other site 479435006255 ABC-ATPase subunit interface; other site 479435006256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435006257 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435006258 Walker A/P-loop; other site 479435006259 ATP binding site [chemical binding]; other site 479435006260 Q-loop/lid; other site 479435006261 ABC transporter signature motif; other site 479435006262 Walker B; other site 479435006263 D-loop; other site 479435006264 H-loop/switch region; other site 479435006265 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435006266 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435006267 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435006268 Walker A/P-loop; other site 479435006269 ATP binding site [chemical binding]; other site 479435006270 Q-loop/lid; other site 479435006271 ABC transporter signature motif; other site 479435006272 Walker B; other site 479435006273 D-loop; other site 479435006274 H-loop/switch region; other site 479435006275 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435006276 DNA polymerase III subunit beta; Validated; Region: PRK07761 479435006277 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 479435006278 putative DNA binding surface [nucleotide binding]; other site 479435006279 dimer interface [polypeptide binding]; other site 479435006280 beta-clamp/translesion DNA polymerase binding surface; other site 479435006281 beta-clamp/clamp loader binding surface; other site 479435006282 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435006283 TM-ABC transporter signature motif; other site 479435006284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006285 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435006286 Walker A/P-loop; other site 479435006287 ATP binding site [chemical binding]; other site 479435006288 Q-loop/lid; other site 479435006289 ABC transporter signature motif; other site 479435006290 Walker B; other site 479435006291 D-loop; other site 479435006292 H-loop/switch region; other site 479435006293 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435006294 putative ligand binding site [chemical binding]; other site 479435006295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006296 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435006297 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435006298 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 479435006299 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 479435006300 homotrimer interface [polypeptide binding]; other site 479435006301 Walker A motif; other site 479435006302 GTP binding site [chemical binding]; other site 479435006303 Walker B motif; other site 479435006304 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 479435006305 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 479435006306 Walker A/P-loop; other site 479435006307 ATP binding site [chemical binding]; other site 479435006308 Q-loop/lid; other site 479435006309 ABC transporter signature motif; other site 479435006310 Walker B; other site 479435006311 D-loop; other site 479435006312 H-loop/switch region; other site 479435006313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006314 Walker A/P-loop; other site 479435006315 ATP binding site [chemical binding]; other site 479435006316 Q-loop/lid; other site 479435006317 ABC transporter signature motif; other site 479435006318 Walker B; other site 479435006319 D-loop; other site 479435006320 H-loop/switch region; other site 479435006321 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435006322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435006323 active site 479435006324 catalytic tetrad [active] 479435006325 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 479435006326 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 479435006327 phage shock protein PspA; Provisional; Region: PRK10698 479435006328 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479435006329 Bacterial sugar transferase; Region: Bac_transf; cl00939 479435006330 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 479435006331 active site 479435006332 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435006333 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435006334 Active Sites [active] 479435006335 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 479435006336 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 479435006337 CysD dimerization site [polypeptide binding]; other site 479435006338 G1 box; other site 479435006339 putative GEF interaction site [polypeptide binding]; other site 479435006340 GTP/Mg2+ binding site [chemical binding]; other site 479435006341 Switch I region; other site 479435006342 G2 box; other site 479435006343 G3 box; other site 479435006344 Switch II region; other site 479435006345 G4 box; other site 479435006346 G5 box; other site 479435006347 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 479435006348 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 479435006349 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; cl07328 479435006350 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 479435006351 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 479435006352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435006353 S-adenosylmethionine binding site [chemical binding]; other site 479435006354 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 479435006355 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435006356 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435006357 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435006358 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435006359 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435006360 MatE; Region: MatE; cl10513 479435006361 Chain length determinant protein; Region: Wzz; cl01623 479435006362 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 479435006363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435006364 active site 479435006365 Chain length determinant protein; Region: Wzz; cl01623 479435006366 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 479435006367 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435006368 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435006369 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435006370 FOG: PKD repeat [General function prediction only]; Region: COG3291 479435006371 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435006372 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435006373 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 479435006374 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435006375 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 479435006376 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 479435006377 ligand-binding site [chemical binding]; other site 479435006378 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479435006379 Bacterial sugar transferase; Region: Bac_transf; cl00939 479435006380 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 479435006381 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 479435006382 NADP binding site [chemical binding]; other site 479435006383 active site 479435006384 putative substrate binding site [chemical binding]; other site 479435006385 GDP-mannose 4,6-dehydratase; Region: PLN02653 479435006386 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 479435006387 NADP-binding site; other site 479435006388 homotetramer interface [polypeptide binding]; other site 479435006389 substrate binding site [chemical binding]; other site 479435006390 homodimer interface [polypeptide binding]; other site 479435006391 active site 479435006392 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 479435006393 LysE type translocator; Region: LysE; cl00565 479435006394 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435006395 Chain length determinant protein; Region: Wzz; cl01623 479435006396 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 479435006397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006398 short chain dehydrogenase; Provisional; Region: PRK08219 479435006399 NAD(P) binding site [chemical binding]; other site 479435006400 active site 479435006401 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 479435006402 Glucuronate isomerase; Region: UxaC; cl00829 479435006403 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 479435006404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006406 DNA binding site [nucleotide binding] 479435006407 domain linker motif; other site 479435006408 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435006409 dimerization interface [polypeptide binding]; other site 479435006410 ligand binding site [chemical binding]; other site 479435006411 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435006412 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435006413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435006414 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 479435006415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435006416 active site 479435006417 HIGH motif; other site 479435006418 nucleotide binding site [chemical binding]; other site 479435006419 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435006420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435006421 active site 479435006422 nucleotide binding site [chemical binding]; other site 479435006423 HIGH motif; other site 479435006424 KMSKS motif; other site 479435006425 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479435006426 Quinolinate synthetase A protein; Region: NadA; cl00420 479435006427 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 479435006428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006429 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 479435006430 nudix motif; other site 479435006431 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 479435006432 Active_site [active] 479435006433 Glycerate kinase family; Region: Gly_kinase; cl00841 479435006434 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 479435006435 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 479435006436 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 479435006437 metal binding site [ion binding]; metal-binding site 479435006438 dimer interface [polypeptide binding]; other site 479435006439 Beta-lactamase; Region: Beta-lactamase; cl01009 479435006440 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435006441 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479435006442 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435006443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006444 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 479435006445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006446 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435006447 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435006448 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 479435006449 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 479435006450 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435006451 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 479435006452 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407 479435006453 NAD+ binding site [chemical binding]; other site 479435006454 substrate binding site [chemical binding]; other site 479435006455 Zn binding site [ion binding]; other site 479435006456 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435006457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435006458 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 479435006459 CPxP motif; other site 479435006460 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 479435006461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435006462 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435006463 catalytic residue [active] 479435006464 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 479435006465 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435006466 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479435006467 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479435006468 D-pathway; other site 479435006469 Putative ubiquinol binding site [chemical binding]; other site 479435006470 Low-spin heme (heme b) binding site [chemical binding]; other site 479435006471 Putative water exit pathway; other site 479435006472 Binuclear center (heme o3/CuB) [ion binding]; other site 479435006473 K-pathway; other site 479435006474 Putative proton exit pathway; other site 479435006475 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 479435006476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479435006477 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435006478 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435006479 YCII-related domain; Region: YCII; cl00999 479435006480 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435006481 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 479435006482 heme bH binding site [chemical binding]; other site 479435006483 Qi binding site; other site 479435006484 intrachain domain interface; other site 479435006485 heme bL binding site [chemical binding]; other site 479435006486 interchain domain interface [polypeptide binding]; other site 479435006487 Qo binding site; other site 479435006488 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 479435006489 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 479435006490 iron-sulfur cluster [ion binding]; other site 479435006491 [2Fe-2S] cluster binding site [ion binding]; other site 479435006492 Cytochrome c; Region: Cytochrom_C; cl11414 479435006493 Cytochrome c; Region: Cytochrom_C; cl11414 479435006494 Cytochrome c; Region: Cytochrom_C; cl11414 479435006495 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 479435006496 Subunit I/III interface [polypeptide binding]; other site 479435006497 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 479435006498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 479435006499 active site 479435006500 phosphorylation site [posttranslational modification] 479435006501 intermolecular recognition site; other site 479435006502 dimerization interface [polypeptide binding]; other site 479435006503 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 479435006504 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479435006505 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479435006506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006507 hypothetical protein; Validated; Region: PRK07883 479435006508 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 479435006509 active site 479435006510 substrate binding site [chemical binding]; other site 479435006511 catalytic site [active] 479435006512 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479435006513 GIY-YIG motif/motif A; other site 479435006514 active site 479435006515 catalytic site [active] 479435006516 putative DNA binding site [nucleotide binding]; other site 479435006517 metal binding site [ion binding]; metal-binding site 479435006518 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 479435006519 Protein of unknown function (DUF972); Region: DUF972; cl01853 479435006520 YacP-like NYN domain; Region: NYN_YacP; cl01491 479435006521 NlpC/P60 family; Region: NLPC_P60; cl11438 479435006522 Peptidase family M48; Region: Peptidase_M48; cl12018 479435006523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435006524 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435006525 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 479435006526 motif 1; other site 479435006527 active site 479435006528 motif 2; other site 479435006529 motif 3; other site 479435006530 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479435006531 EamA-like transporter family; Region: EamA; cl01037 479435006532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006533 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435006534 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 479435006535 catalytic triad [active] 479435006536 conserved cis-peptide bond; other site 479435006537 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435006538 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435006539 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006541 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435006542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435006543 active site 479435006544 metal binding site [ion binding]; metal-binding site 479435006545 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 479435006546 catalytic triad [active] 479435006547 conserved cis-peptide bond; other site 479435006548 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 479435006549 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435006550 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 479435006551 putative hydrophobic ligand binding site [chemical binding]; other site 479435006552 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435006553 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 479435006554 dimerization interface [polypeptide binding]; other site 479435006555 Metal binding site [ion binding]; metal-binding site 479435006556 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 479435006557 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435006558 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 479435006559 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435006560 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435006561 putative metal binding site [ion binding]; other site 479435006562 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435006563 putative catalytic site [active] 479435006564 putative phosphate binding site [ion binding]; other site 479435006565 putative metal binding site [ion binding]; other site 479435006566 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 479435006567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006568 NAD(P) binding site [chemical binding]; other site 479435006569 active site 479435006570 enoyl-CoA hydratase; Provisional; Region: PRK07827 479435006571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435006572 substrate binding site [chemical binding]; other site 479435006573 oxyanion hole (OAH) forming residues; other site 479435006574 trimer interface [polypeptide binding]; other site 479435006575 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435006576 active site 479435006577 metal binding site [ion binding]; metal-binding site 479435006578 TIGR00300 family protein; Region: TIGR00300 479435006579 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 479435006580 Esterase/lipase [General function prediction only]; Region: COG1647 479435006581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435006582 putative acyl-acceptor binding pocket; other site 479435006583 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 479435006584 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 479435006585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435006586 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 479435006587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435006588 catalytic residue [active] 479435006589 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435006590 Phosphotransferase enzyme family; Region: APH; pfam01636 479435006591 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435006592 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 479435006593 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 479435006594 NPCBM/NEW2 domain; Region: NPCBM; cl07060 479435006595 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 479435006596 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435006597 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435006598 translocation protein TolB; Provisional; Region: tolB; PRK02889 479435006599 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435006600 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 479435006601 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435006602 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435006603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435006604 active site 479435006605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006607 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 479435006608 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479435006609 EamA-like transporter family; Region: EamA; cl01037 479435006610 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435006611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435006612 active site 479435006613 ATP binding site [chemical binding]; other site 479435006614 substrate binding site [chemical binding]; other site 479435006615 activation loop (A-loop); other site 479435006616 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435006617 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435006618 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435006619 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435006620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 479435006621 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 479435006622 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 479435006623 putative peptidoglycan binding site; other site 479435006624 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 479435006625 putative peptidoglycan binding site; other site 479435006626 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 479435006627 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435006628 catalytic residue [active] 479435006629 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 479435006630 ThiS interaction site; other site 479435006631 putative active site [active] 479435006632 tetramer interface [polypeptide binding]; other site 479435006633 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 479435006634 thiS-thiF/thiG interaction site; other site 479435006635 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 479435006636 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435006637 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 479435006638 thiamine phosphate binding site [chemical binding]; other site 479435006639 active site 479435006640 pyrophosphate binding site [ion binding]; other site 479435006641 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 479435006642 active site 479435006643 barstar interaction site; other site 479435006644 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 479435006645 RNAase interaction site [polypeptide binding]; other site 479435006646 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 479435006647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006648 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479435006649 DNA binding residues [nucleotide binding] 479435006650 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435006651 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435006652 substrate binding pocket [chemical binding]; other site 479435006653 chain length determination region; other site 479435006654 substrate-Mg2+ binding site; other site 479435006655 catalytic residues [active] 479435006656 aspartate-rich region 1; other site 479435006657 active site lid residues [active] 479435006658 aspartate-rich region 2; other site 479435006659 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 479435006660 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 479435006661 FAD binding site [chemical binding]; other site 479435006662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435006663 catalytic core [active] 479435006664 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435006665 PhoH-like protein; Region: PhoH; cl12134 479435006666 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435006667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006668 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435006669 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435006670 amidase catalytic site [active] 479435006671 Zn binding residues [ion binding]; other site 479435006672 substrate binding site [chemical binding]; other site 479435006673 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 479435006674 putative deacylase active site [active] 479435006675 Electron transfer DM13; Region: DM13; cl02735 479435006676 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435006677 hypothetical protein; Provisional; Region: PRK08317 479435006678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435006679 S-adenosylmethionine binding site [chemical binding]; other site 479435006680 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479435006681 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 479435006682 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435006683 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435006684 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435006685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435006686 Walker A motif; other site 479435006687 ATP binding site [chemical binding]; other site 479435006688 Walker B motif; other site 479435006689 arginine finger; other site 479435006690 cell division protein MraZ; Reviewed; Region: PRK00326 479435006691 MraZ protein; Region: MraZ; pfam02381 479435006692 MraZ protein; Region: MraZ; pfam02381 479435006693 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 479435006694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435006695 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 479435006696 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435006697 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435006698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435006699 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 479435006700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435006701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435006702 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 479435006703 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479435006704 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435006705 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435006706 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 479435006707 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 479435006708 Mg++ binding site [ion binding]; other site 479435006709 putative catalytic motif [active] 479435006710 putative substrate binding site [chemical binding]; other site 479435006711 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 479435006712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435006713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435006714 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 479435006715 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 479435006716 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 479435006717 active site 479435006718 homodimer interface [polypeptide binding]; other site 479435006719 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 479435006720 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479435006721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435006722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435006723 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 479435006724 Cell division protein FtsQ; Region: FtsQ; pfam03799 479435006725 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 479435006726 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 479435006727 nucleotide binding site [chemical binding]; other site 479435006728 SulA interaction site; other site 479435006729 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 479435006730 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 479435006731 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 479435006732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435006733 catalytic residue [active] 479435006734 Protein of unknown function (DUF552); Region: DUF552; cl00775 479435006735 DivIVA domain; Region: DivI1A_domain; TIGR03544 479435006736 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 479435006737 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 479435006738 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479435006739 HIGH motif; other site 479435006740 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479435006741 active site 479435006742 KMSKS motif; other site 479435006743 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 479435006744 tRNA binding surface [nucleotide binding]; other site 479435006745 anticodon binding site; other site 479435006746 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 479435006747 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 479435006748 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 479435006749 lipoprotein signal peptidase; Provisional; Region: PRK14787 479435006750 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 479435006751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 479435006752 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 479435006753 active site 479435006754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435006755 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435006756 conserved cys residue [active] 479435006757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435006758 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 479435006759 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435006760 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 479435006761 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 479435006762 generic binding surface II; other site 479435006763 generic binding surface I; other site 479435006764 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 479435006765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435006767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435006768 putative substrate translocation pore; other site 479435006769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006770 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435006771 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 479435006772 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 479435006773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435006774 ATP binding site [chemical binding]; other site 479435006775 putative Mg++ binding site [ion binding]; other site 479435006776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435006777 nucleotide binding region [chemical binding]; other site 479435006778 ATP-binding site [chemical binding]; other site 479435006779 RQC domain; Region: RQC; cl09632 479435006780 HRDC domain; Region: HRDC; cl02578 479435006781 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435006782 active site 479435006783 catalytic residues [active] 479435006784 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435006785 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435006786 Dehydratase family; Region: ILVD_EDD; cl00340 479435006787 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 479435006788 PemK-like protein; Region: PemK; cl00995 479435006789 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 479435006790 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 479435006791 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 479435006792 NAD binding site [chemical binding]; other site 479435006793 dimerization interface [polypeptide binding]; other site 479435006794 product binding site; other site 479435006795 substrate binding site [chemical binding]; other site 479435006796 zinc binding site [ion binding]; other site 479435006797 catalytic residues [active] 479435006798 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 479435006799 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435006800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435006801 homodimer interface [polypeptide binding]; other site 479435006802 catalytic residue [active] 479435006803 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 479435006804 putative active site pocket [active] 479435006805 4-fold oligomerization interface [polypeptide binding]; other site 479435006806 metal binding residues [ion binding]; metal-binding site 479435006807 3-fold/trimer interface [polypeptide binding]; other site 479435006808 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 479435006809 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 479435006810 putative active site [active] 479435006811 oxyanion strand; other site 479435006812 catalytic triad [active] 479435006813 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435006814 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435006815 putative ligand binding site [chemical binding]; other site 479435006816 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 479435006817 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 479435006818 Walker A/P-loop; other site 479435006819 ATP binding site [chemical binding]; other site 479435006820 Q-loop/lid; other site 479435006821 ABC transporter signature motif; other site 479435006822 Walker B; other site 479435006823 D-loop; other site 479435006824 H-loop/switch region; other site 479435006825 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435006826 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435006827 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435006828 TM-ABC transporter signature motif; other site 479435006829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006831 DNA binding site [nucleotide binding] 479435006832 domain linker motif; other site 479435006833 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 479435006834 ligand binding site [chemical binding]; other site 479435006835 dimerization interface (open form) [polypeptide binding]; other site 479435006836 dimerization interface (closed form) [polypeptide binding]; other site 479435006837 hypothetical protein; Provisional; Region: PRK07206 479435006838 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435006840 putative substrate translocation pore; other site 479435006841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435006842 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 479435006843 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435006844 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435006845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006846 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435006847 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 479435006848 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 479435006849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435006850 active site 479435006851 HIGH motif; other site 479435006852 nucleotide binding site [chemical binding]; other site 479435006853 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435006854 active site 479435006855 KMSKS motif; other site 479435006856 Cupin domain; Region: Cupin_2; cl09118 479435006857 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435006858 dinuclear metal binding motif [ion binding]; other site 479435006859 ribosome maturation protein RimP; Reviewed; Region: PRK00092 479435006860 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 479435006861 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 479435006862 Sm1 motif; other site 479435006863 D3 - B interaction site; other site 479435006864 D1 - D2 interaction site; other site 479435006865 Hfq - Hfq interaction site; other site 479435006866 RNA binding pocket [nucleotide binding]; other site 479435006867 Sm2 motif; other site 479435006868 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 479435006869 NusA N-terminal domain; Region: NusA_N; pfam08529 479435006870 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 479435006871 RNA binding site [nucleotide binding]; other site 479435006872 homodimer interface [polypeptide binding]; other site 479435006873 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 479435006874 G-X-X-G motif; other site 479435006875 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 479435006876 putative RNA binding cleft [nucleotide binding]; other site 479435006877 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 479435006878 translation initiation factor IF-2; Region: IF-2; TIGR00487 479435006879 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 479435006880 G1 box; other site 479435006881 putative GEF interaction site [polypeptide binding]; other site 479435006882 GTP/Mg2+ binding site [chemical binding]; other site 479435006883 Switch I region; other site 479435006884 G2 box; other site 479435006885 G3 box; other site 479435006886 Switch II region; other site 479435006887 G4 box; other site 479435006888 G5 box; other site 479435006889 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 479435006890 Translation-initiation factor 2; Region: IF-2; pfam11987 479435006891 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 479435006892 Ribosome-binding factor A; Region: RBFA; cl00542 479435006893 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 479435006894 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 479435006895 RNA binding site [nucleotide binding]; other site 479435006896 active site 479435006897 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435006898 active site 479435006899 ATP binding site [chemical binding]; other site 479435006900 Phosphotransferase enzyme family; Region: APH; pfam01636 479435006901 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479435006902 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 479435006903 large tegument protein UL36; Provisional; Region: PHA03247 479435006904 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 479435006905 active site 479435006906 putative catalytic site [active] 479435006907 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 479435006908 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 479435006909 NAD+ binding site [chemical binding]; other site 479435006910 substrate binding site [chemical binding]; other site 479435006911 Zn binding site [ion binding]; other site 479435006912 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435006913 active site 479435006914 catalytic triad [active] 479435006915 oxyanion hole [active] 479435006916 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 479435006917 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 479435006918 active site 479435006919 Riboflavin kinase; Region: Flavokinase; cl03312 479435006920 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 479435006921 16S/18S rRNA binding site [nucleotide binding]; other site 479435006922 S13e-L30e interaction site [polypeptide binding]; other site 479435006923 25S rRNA binding site [nucleotide binding]; other site 479435006924 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 479435006925 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 479435006926 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 479435006927 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 479435006928 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 479435006929 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 479435006930 putative nucleic acid binding region [nucleotide binding]; other site 479435006931 G-X-X-G motif; other site 479435006932 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 479435006933 RNA binding site [nucleotide binding]; other site 479435006934 domain interface; other site 479435006935 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435006936 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435006937 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435006938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006939 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435006940 Walker A/P-loop; other site 479435006941 ATP binding site [chemical binding]; other site 479435006942 Q-loop/lid; other site 479435006943 ABC transporter signature motif; other site 479435006944 Walker B; other site 479435006945 D-loop; other site 479435006946 H-loop/switch region; other site 479435006947 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435006948 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435006949 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435006950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435006951 dimer interface [polypeptide binding]; other site 479435006952 conserved gate region; other site 479435006953 putative PBP binding loops; other site 479435006954 ABC-ATPase subunit interface; other site 479435006955 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 479435006956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435006957 dimer interface [polypeptide binding]; other site 479435006958 conserved gate region; other site 479435006959 putative PBP binding loops; other site 479435006960 ABC-ATPase subunit interface; other site 479435006961 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435006962 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435006963 Walker A/P-loop; other site 479435006964 ATP binding site [chemical binding]; other site 479435006965 Q-loop/lid; other site 479435006966 ABC transporter signature motif; other site 479435006967 Walker B; other site 479435006968 D-loop; other site 479435006969 H-loop/switch region; other site 479435006970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435006971 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435006972 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435006973 Walker A/P-loop; other site 479435006974 ATP binding site [chemical binding]; other site 479435006975 Q-loop/lid; other site 479435006976 ABC transporter signature motif; other site 479435006977 Walker B; other site 479435006978 D-loop; other site 479435006979 H-loop/switch region; other site 479435006980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435006981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006982 Coenzyme A binding pocket [chemical binding]; other site 479435006983 dihydrodipicolinate reductase; Provisional; Region: PRK00048 479435006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006985 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 479435006986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435006987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435006988 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435006989 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435006990 DinB superfamily; Region: DinB_2; cl00986 479435006991 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 479435006992 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435006993 putative NAD(P) binding site [chemical binding]; other site 479435006994 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435006995 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435006996 conserved cys residue [active] 479435006997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006999 Coenzyme A binding pocket [chemical binding]; other site 479435007000 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 479435007001 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 479435007002 Phenylacetic acid degradation B; Region: PaaB; cl01371 479435007003 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 479435007004 Domain of unknown function DUF59; Region: DUF59; cl00941 479435007005 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 479435007006 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 479435007007 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 479435007008 FAD binding pocket [chemical binding]; other site 479435007009 FAD binding motif [chemical binding]; other site 479435007010 phosphate binding motif [ion binding]; other site 479435007011 beta-alpha-beta structure motif; other site 479435007012 NAD(p) ribose binding residues [chemical binding]; other site 479435007013 NAD binding pocket [chemical binding]; other site 479435007014 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 479435007015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435007016 catalytic loop [active] 479435007017 iron binding site [ion binding]; other site 479435007018 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435007019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435007020 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 479435007021 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 479435007022 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435007023 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 479435007024 dimer interface [polypeptide binding]; other site 479435007025 active site 479435007026 catalytic residue [active] 479435007027 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 479435007028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435007029 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 479435007030 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435007031 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435007032 DNA binding site [nucleotide binding] 479435007033 domain linker motif; other site 479435007034 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435007035 dimerization interface [polypeptide binding]; other site 479435007036 ligand binding site [chemical binding]; other site 479435007037 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 479435007038 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479435007039 putative di-iron ligands [ion binding]; other site 479435007040 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 479435007041 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435007042 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435007043 putative active site [active] 479435007044 putative metal binding site [ion binding]; other site 479435007045 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435007046 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435007047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435007048 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435007049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007051 catalytic residue [active] 479435007052 DinB superfamily; Region: DinB_2; cl00986 479435007053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007054 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 479435007055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435007056 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479435007057 Radical SAM; Region: Elp3; smart00729 479435007058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435007059 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435007060 Competence-damaged protein; Region: CinA; cl00666 479435007061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435007062 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435007063 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 479435007064 putative DNA binding site [nucleotide binding]; other site 479435007065 catalytic residue [active] 479435007066 putative H2TH interface [polypeptide binding]; other site 479435007067 putative catalytic residues [active] 479435007068 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435007069 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435007070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435007071 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 479435007072 ATP binding site [chemical binding]; other site 479435007073 putative Mg++ binding site [ion binding]; other site 479435007074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435007075 nucleotide binding region [chemical binding]; other site 479435007076 ATP-binding site [chemical binding]; other site 479435007077 DEAD/H associated; Region: DEAD_assoc; pfam08494 479435007078 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 479435007079 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 479435007080 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 479435007081 recombinase A; Provisional; Region: recA; PRK09354 479435007082 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 479435007083 hexamer interface [polypeptide binding]; other site 479435007084 Walker A motif; other site 479435007085 ATP binding site [chemical binding]; other site 479435007086 Walker B motif; other site 479435007087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435007088 nudix motif; other site 479435007089 phosphodiesterase; Provisional; Region: PRK12704 479435007090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435007091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435007092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435007093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435007094 active site 479435007095 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435007096 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 479435007097 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 479435007098 catalytic triad [active] 479435007099 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 479435007100 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 479435007101 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 479435007102 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 479435007103 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 479435007104 active site 479435007105 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 479435007106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 479435007107 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 479435007108 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 479435007109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007110 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007111 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435007112 DNA binding residues [nucleotide binding] 479435007113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435007114 catalytic residues [active] 479435007115 HicB family; Region: HicB; pfam05534 479435007116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435007117 active site 479435007118 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007119 Predicted acetyltransferase [General function prediction only]; Region: COG3393 479435007120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435007121 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 479435007122 active site 479435007123 Zn-binding site [ion binding]; other site 479435007124 Predicted membrane protein [Function unknown]; Region: COG4270 479435007125 prolyl-tRNA synthetase; Provisional; Region: PRK09194 479435007126 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 479435007127 dimer interface [polypeptide binding]; other site 479435007128 motif 1; other site 479435007129 active site 479435007130 motif 2; other site 479435007131 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479435007132 putative deacylase active site [active] 479435007133 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435007134 active site 479435007135 motif 3; other site 479435007136 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 479435007137 anticodon binding site; other site 479435007138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435007139 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435007140 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435007141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007142 NAD(P) binding site [chemical binding]; other site 479435007143 active site 479435007144 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 479435007145 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435007146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007147 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435007148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435007150 binding surface 479435007151 TPR motif; other site 479435007152 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435007153 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 479435007154 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 479435007155 catalytic residues [active] 479435007156 fatty acyl-CoA reductase; Region: PLN02996 479435007157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007158 NAD(P) binding site [chemical binding]; other site 479435007159 active site 479435007160 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 479435007161 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479435007162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435007163 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435007164 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435007165 NAD(P) binding site [chemical binding]; other site 479435007166 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 479435007167 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435007168 putative acyl-acceptor binding pocket; other site 479435007169 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 479435007170 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 479435007171 substrate binding site [chemical binding]; other site 479435007172 glutamase interaction surface [polypeptide binding]; other site 479435007173 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 479435007174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007175 RNA polymerase sigma factor; Provisional; Region: PRK12528 479435007176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435007178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435007179 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 479435007180 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 479435007181 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 479435007182 putative substrate binding site [chemical binding]; other site 479435007183 active site 479435007184 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 479435007185 Ca binding site [ion binding]; other site 479435007186 Sulfatase; Region: Sulfatase; cl10460 479435007187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435007188 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435007189 TIGR03085 family protein; Region: TIGR03085 479435007190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435007191 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435007192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007193 Walker A/P-loop; other site 479435007194 ATP binding site [chemical binding]; other site 479435007195 Q-loop/lid; other site 479435007196 ABC transporter signature motif; other site 479435007197 Walker B; other site 479435007198 D-loop; other site 479435007199 H-loop/switch region; other site 479435007200 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435007201 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435007202 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 479435007203 Walker A/P-loop; other site 479435007204 ATP binding site [chemical binding]; other site 479435007205 Q-loop/lid; other site 479435007206 ABC transporter signature motif; other site 479435007207 Walker B; other site 479435007208 D-loop; other site 479435007209 H-loop/switch region; other site 479435007210 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 479435007211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435007212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435007213 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 479435007214 active site 479435007215 dimer interface [polypeptide binding]; other site 479435007216 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 479435007217 anthranilate synthase component I; Provisional; Region: PRK13571 479435007218 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435007219 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435007220 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 479435007221 active site 479435007222 ribulose/triose binding site [chemical binding]; other site 479435007223 phosphate binding site [ion binding]; other site 479435007224 substrate (anthranilate) binding pocket [chemical binding]; other site 479435007225 product (indole) binding pocket [chemical binding]; other site 479435007226 tryptophan synthase, beta chain; Region: PLN02618 479435007227 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479435007228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435007229 catalytic residue [active] 479435007230 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 479435007231 substrate binding site [chemical binding]; other site 479435007232 active site 479435007233 catalytic residues [active] 479435007234 heterodimer interface [polypeptide binding]; other site 479435007235 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 479435007236 Cu(I) binding site [ion binding]; other site 479435007237 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 479435007238 catalytic residues [active] 479435007239 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 479435007240 UV excision repair protein Rad23; Region: rad23; TIGR00601 479435007241 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 479435007242 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435007243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007245 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435007246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435007247 binding surface 479435007248 TPR motif; other site 479435007249 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 479435007250 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 479435007251 active site 479435007252 dimer interface [polypeptide binding]; other site 479435007253 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 479435007254 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 479435007255 active site 479435007256 FMN binding site [chemical binding]; other site 479435007257 substrate binding site [chemical binding]; other site 479435007258 3Fe-4S cluster binding site [ion binding]; other site 479435007259 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 479435007260 domain interface; other site 479435007261 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 479435007262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007263 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435007264 active site 479435007265 metal binding site [ion binding]; metal-binding site 479435007266 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435007267 pyruvate kinase; Provisional; Region: PRK06247 479435007268 domain interfaces; other site 479435007269 active site 479435007270 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479435007271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435007272 active site 479435007273 phosphorylation site [posttranslational modification] 479435007274 intermolecular recognition site; other site 479435007275 dimerization interface [polypeptide binding]; other site 479435007276 ANTAR domain; Region: ANTAR; cl04297 479435007277 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 479435007278 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 479435007279 dimerization interface [polypeptide binding]; other site 479435007280 ligand binding site [chemical binding]; other site 479435007281 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479435007282 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479435007283 TM-ABC transporter signature motif; other site 479435007284 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 479435007285 TM-ABC transporter signature motif; other site 479435007286 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479435007287 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 479435007288 Walker A/P-loop; other site 479435007289 ATP binding site [chemical binding]; other site 479435007290 Q-loop/lid; other site 479435007291 ABC transporter signature motif; other site 479435007292 Walker B; other site 479435007293 D-loop; other site 479435007294 H-loop/switch region; other site 479435007295 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479435007296 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 479435007297 Walker A/P-loop; other site 479435007298 ATP binding site [chemical binding]; other site 479435007299 Q-loop/lid; other site 479435007300 ABC transporter signature motif; other site 479435007301 Walker B; other site 479435007302 D-loop; other site 479435007303 H-loop/switch region; other site 479435007304 Protein of unknown function (DUF554); Region: DUF554; cl00784 479435007305 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435007306 CoenzymeA binding site [chemical binding]; other site 479435007307 subunit interaction site [polypeptide binding]; other site 479435007308 PHB binding site; other site 479435007309 DNA polymerase I; Provisional; Region: PRK05755 479435007310 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479435007311 active site 479435007312 metal binding site 1 [ion binding]; metal-binding site 479435007313 putative 5' ssDNA interaction site; other site 479435007314 metal binding site 3; metal-binding site 479435007315 metal binding site 2 [ion binding]; metal-binding site 479435007316 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479435007317 putative DNA binding site [nucleotide binding]; other site 479435007318 putative metal binding site [ion binding]; other site 479435007319 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 479435007320 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 479435007321 active site 479435007322 DNA binding site [nucleotide binding] 479435007323 catalytic site [active] 479435007324 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 479435007325 nudix motif; other site 479435007326 MatE; Region: MatE; cl10513 479435007327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435007328 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435007329 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 479435007330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435007331 S-adenosylmethionine binding site [chemical binding]; other site 479435007332 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 479435007333 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435007334 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435007335 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479435007336 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 479435007337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435007338 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435007339 DNA binding residues [nucleotide binding] 479435007340 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 479435007341 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 479435007342 putative hydrophobic ligand binding site [chemical binding]; other site 479435007343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435007344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435007345 Phosphotransferase enzyme family; Region: APH; pfam01636 479435007346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435007347 active site 479435007348 ATP binding site [chemical binding]; other site 479435007349 substrate binding site [chemical binding]; other site 479435007350 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 479435007351 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 479435007352 RNA binding site [nucleotide binding]; other site 479435007353 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 479435007354 RNA binding site [nucleotide binding]; other site 479435007355 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 479435007356 RNA binding site [nucleotide binding]; other site 479435007357 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 479435007358 RNA binding site [nucleotide binding]; other site 479435007359 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435007360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435007362 binding surface 479435007363 TPR motif; other site 479435007364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435007365 binding surface 479435007366 TPR motif; other site 479435007367 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 479435007368 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 479435007369 CoA-binding site [chemical binding]; other site 479435007370 ATP-binding [chemical binding]; other site 479435007371 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 479435007372 excinuclease ABC subunit B; Provisional; Region: PRK05298 479435007373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007374 putative Mg++ binding site [ion binding]; other site 479435007375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435007376 nucleotide binding region [chemical binding]; other site 479435007377 ATP-binding site [chemical binding]; other site 479435007378 Ultra-violet resistance protein B; Region: UvrB; pfam12344 479435007379 UvrB/uvrC motif; Region: UVR; pfam02151 479435007380 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435007381 Integral membrane protein TerC family; Region: TerC; cl10468 479435007382 NlpC/P60 family; Region: NLPC_P60; cl11438 479435007383 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435007384 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 479435007385 active site 479435007386 Beta-lactamase; Region: Beta-lactamase; cl01009 479435007387 CobD/Cbib protein; Region: CobD_Cbib; cl00561 479435007388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435007389 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435007390 catalytic core [active] 479435007391 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 479435007392 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 479435007393 Survival protein SurE; Region: SurE; cl00448 479435007394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007396 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 479435007397 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 479435007398 metal ion-dependent adhesion site (MIDAS); other site 479435007399 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 479435007400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007401 Walker A motif; other site 479435007402 ATP binding site [chemical binding]; other site 479435007403 Walker B motif; other site 479435007404 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 479435007405 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435007406 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 479435007407 catalytic triad [active] 479435007408 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 479435007409 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 479435007410 putative FMN binding site [chemical binding]; other site 479435007411 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 479435007412 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435007413 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007414 Walker A/P-loop; other site 479435007415 ATP binding site [chemical binding]; other site 479435007416 Q-loop/lid; other site 479435007417 ABC transporter signature motif; other site 479435007418 Walker B; other site 479435007419 D-loop; other site 479435007420 H-loop/switch region; other site 479435007421 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 479435007422 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 479435007423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435007424 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 479435007425 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435007426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435007428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435007429 active site 479435007430 phosphorylation site [posttranslational modification] 479435007431 intermolecular recognition site; other site 479435007432 dimerization interface [polypeptide binding]; other site 479435007433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435007434 DNA binding residues [nucleotide binding] 479435007435 dimerization interface [polypeptide binding]; other site 479435007436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435007437 Histidine kinase; Region: HisKA_3; pfam07730 479435007438 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435007439 NMT1/THI5 like; Region: NMT1; pfam09084 479435007440 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479435007441 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 479435007442 Walker A/P-loop; other site 479435007443 ATP binding site [chemical binding]; other site 479435007444 Q-loop/lid; other site 479435007445 ABC transporter signature motif; other site 479435007446 Walker B; other site 479435007447 D-loop; other site 479435007448 H-loop/switch region; other site 479435007449 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435007450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435007451 dimer interface [polypeptide binding]; other site 479435007452 conserved gate region; other site 479435007453 putative PBP binding loops; other site 479435007454 ABC-ATPase subunit interface; other site 479435007455 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 479435007456 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435007457 homotrimer interaction site [polypeptide binding]; other site 479435007458 putative active site [active] 479435007459 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479435007460 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435007461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007462 DNA-binding site [nucleotide binding]; DNA binding site 479435007463 FCD domain; Region: FCD; cl11656 479435007464 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435007465 classical (c) SDRs; Region: SDR_c; cd05233 479435007466 NAD(P) binding site [chemical binding]; other site 479435007467 active site 479435007468 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 479435007469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007470 Cupin domain; Region: Cupin_2; cl09118 479435007471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435007472 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435007473 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435007474 NAD(P) binding site [chemical binding]; other site 479435007475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435007476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435007477 DNA-binding site [nucleotide binding]; DNA binding site 479435007478 FCD domain; Region: FCD; cl11656 479435007479 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435007480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 479435007481 DNA Polymerase Y-family; Region: PolY_like; cd03468 479435007482 active site 479435007483 DNA binding site [nucleotide binding] 479435007484 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435007485 Beta-lactamase; Region: Beta-lactamase; cl01009 479435007486 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435007487 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435007488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435007489 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435007490 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479435007491 putative NAD(P) binding site [chemical binding]; other site 479435007492 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435007493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435007494 YCII-related domain; Region: YCII; cl00999 479435007495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435007496 dimerization interface [polypeptide binding]; other site 479435007497 putative DNA binding site [nucleotide binding]; other site 479435007498 putative Zn2+ binding site [ion binding]; other site 479435007499 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435007500 putative hydrophobic ligand binding site [chemical binding]; other site 479435007501 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435007502 TIGR03086 family protein; Region: TIGR03086 479435007503 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435007504 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435007505 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 479435007506 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435007507 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 479435007508 lipoyl attachment site [posttranslational modification]; other site 479435007509 Double zinc ribbon; Region: DZR; pfam12773 479435007510 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435007511 phosphopeptide binding site; other site 479435007512 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435007513 DNA binding residues [nucleotide binding] 479435007514 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 479435007515 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 479435007516 DNA binding residues [nucleotide binding] 479435007517 putative dimer interface [polypeptide binding]; other site 479435007518 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435007519 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435007520 inhibitor site; inhibition site 479435007521 active site 479435007522 dimer interface [polypeptide binding]; other site 479435007523 catalytic residue [active] 479435007524 glycine dehydrogenase; Provisional; Region: PRK05367 479435007525 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 479435007526 tetramer interface [polypeptide binding]; other site 479435007527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435007528 catalytic residue [active] 479435007529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007531 catalytic residue [active] 479435007532 Beta-lactamase; Region: Beta-lactamase; cl01009 479435007533 short chain dehydrogenase; Provisional; Region: PRK08278 479435007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007535 NAD(P) binding site [chemical binding]; other site 479435007536 active site 479435007537 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 479435007538 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007540 catalytic residue [active] 479435007541 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435007542 IucA / IucC family; Region: IucA_IucC; pfam04183 479435007543 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435007544 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435007545 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 479435007546 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 479435007547 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 479435007548 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435007549 IucA / IucC family; Region: IucA_IucC; pfam04183 479435007550 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435007551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435007552 S-adenosylmethionine binding site [chemical binding]; other site 479435007553 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 479435007554 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 479435007555 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 479435007556 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 479435007557 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435007558 conserved cys residue [active] 479435007559 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435007560 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435007561 DinB superfamily; Region: DinB_2; cl00986 479435007562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435007563 DinB superfamily; Region: DinB_2; cl00986 479435007564 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 479435007565 amphipathic channel; other site 479435007566 Asn-Pro-Ala signature motifs; other site 479435007567 glycerol kinase; Provisional; Region: glpK; PRK00047 479435007568 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 479435007569 N- and C-terminal domain interface [polypeptide binding]; other site 479435007570 putative active site [active] 479435007571 putative MgATP binding site [chemical binding]; other site 479435007572 catalytic site [active] 479435007573 metal binding site [ion binding]; metal-binding site 479435007574 putative homotetramer interface [polypeptide binding]; other site 479435007575 putative glycerol binding site [chemical binding]; other site 479435007576 homodimer interface [polypeptide binding]; other site 479435007577 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479435007578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007580 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435007581 glycerol kinase; Provisional; Region: glpK; PRK00047 479435007582 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 479435007583 N- and C-terminal domain interface [polypeptide binding]; other site 479435007584 putative active site [active] 479435007585 putative MgATP binding site [chemical binding]; other site 479435007586 catalytic site [active] 479435007587 metal binding site [ion binding]; metal-binding site 479435007588 putative homotetramer interface [polypeptide binding]; other site 479435007589 putative glycerol binding site [chemical binding]; other site 479435007590 homodimer interface [polypeptide binding]; other site 479435007591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007592 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435007593 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435007594 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435007595 FtsX-like permease family; Region: FtsX; pfam02687 479435007596 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435007597 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435007598 Walker A/P-loop; other site 479435007599 ATP binding site [chemical binding]; other site 479435007600 Q-loop/lid; other site 479435007601 ABC transporter signature motif; other site 479435007602 Walker B; other site 479435007603 D-loop; other site 479435007604 H-loop/switch region; other site 479435007605 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 479435007606 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435007607 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 479435007608 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435007609 VPS10 domain; Region: VPS10; smart00602 479435007610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435007611 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435007612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435007613 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435007614 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 479435007615 Walker A/P-loop; other site 479435007616 ATP binding site [chemical binding]; other site 479435007617 Q-loop/lid; other site 479435007618 ABC transporter signature motif; other site 479435007619 Walker B; other site 479435007620 D-loop; other site 479435007621 H-loop/switch region; other site 479435007622 TOBE domain; Region: TOBE_2; cl01440 479435007623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435007624 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 479435007625 putative active site [active] 479435007626 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 479435007627 active site 479435007628 putative substrate binding region [chemical binding]; other site 479435007629 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435007630 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 479435007631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435007632 proteasome ATPase; Region: pup_AAA; TIGR03689 479435007633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435007634 Walker A motif; other site 479435007635 ATP binding site [chemical binding]; other site 479435007636 Walker B motif; other site 479435007637 arginine finger; other site 479435007638 RNA polymerase sigma factor; Provisional; Region: PRK12519 479435007639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007640 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435007641 active site 479435007642 ATP binding site [chemical binding]; other site 479435007643 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435007644 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435007645 nudix motif; other site 479435007646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007647 NAD(P) binding site [chemical binding]; other site 479435007648 active site 479435007649 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 479435007650 Pup-ligase protein; Region: Pup_ligase; pfam03136 479435007651 Pup-like protein; Region: Pup; cl05289 479435007652 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 479435007653 active site 479435007654 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 479435007655 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 479435007656 active site 479435007657 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 479435007658 dimer interface [polypeptide binding]; other site 479435007659 ADP-ribose binding site [chemical binding]; other site 479435007660 active site 479435007661 nudix motif; other site 479435007662 metal binding site [ion binding]; metal-binding site 479435007663 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 479435007664 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 479435007665 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435007666 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435007667 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435007668 Walker A/P-loop; other site 479435007669 ATP binding site [chemical binding]; other site 479435007670 Q-loop/lid; other site 479435007671 ABC transporter signature motif; other site 479435007672 Walker B; other site 479435007673 D-loop; other site 479435007674 H-loop/switch region; other site 479435007675 FtsX-like permease family; Region: FtsX; pfam02687 479435007676 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435007677 FtsX-like permease family; Region: FtsX; pfam02687 479435007678 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 479435007679 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 479435007680 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 479435007681 homodimer interface [polypeptide binding]; other site 479435007682 NADP binding site [chemical binding]; other site 479435007683 substrate binding site [chemical binding]; other site 479435007684 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 479435007685 homotrimer interaction site [polypeptide binding]; other site 479435007686 active site 479435007687 prephenate dehydrogenase; Validated; Region: PRK06545 479435007688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435007690 cytidylate kinase; Provisional; Region: cmk; PRK00023 479435007691 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 479435007692 CMP-binding site; other site 479435007693 The sites determining sugar specificity; other site 479435007694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435007695 putative acyl-acceptor binding pocket; other site 479435007696 GTP-binding protein Der; Reviewed; Region: PRK03003 479435007697 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 479435007698 G1 box; other site 479435007699 GTP/Mg2+ binding site [chemical binding]; other site 479435007700 Switch I region; other site 479435007701 G2 box; other site 479435007702 Switch II region; other site 479435007703 G3 box; other site 479435007704 G4 box; other site 479435007705 G5 box; other site 479435007706 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 479435007707 G1 box; other site 479435007708 GTP/Mg2+ binding site [chemical binding]; other site 479435007709 Switch I region; other site 479435007710 G2 box; other site 479435007711 G3 box; other site 479435007712 Switch II region; other site 479435007713 G4 box; other site 479435007714 G5 box; other site 479435007715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435007716 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 479435007717 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 479435007718 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 479435007719 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 479435007720 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435007721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007722 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479435007723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007724 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 479435007725 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 479435007726 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 479435007727 iron-sulfur cluster [ion binding]; other site 479435007728 [2Fe-2S] cluster binding site [ion binding]; other site 479435007729 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435007730 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 479435007731 calcium binding site 2 [ion binding]; other site 479435007732 active site 479435007733 catalytic triad [active] 479435007734 calcium binding site 1 [ion binding]; other site 479435007735 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 479435007736 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479435007737 GIY-YIG motif/motif A; other site 479435007738 active site 479435007739 catalytic site [active] 479435007740 putative DNA binding site [nucleotide binding]; other site 479435007741 metal binding site [ion binding]; metal-binding site 479435007742 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 479435007743 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007744 shikimate kinase; Reviewed; Region: aroK; PRK00131 479435007745 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 479435007746 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 479435007747 putative substrate binding pocket [chemical binding]; other site 479435007748 dimer interface [polypeptide binding]; other site 479435007749 phosphate binding site [ion binding]; other site 479435007750 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435007751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435007753 DNA binding residues [nucleotide binding] 479435007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 479435007755 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 479435007756 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 479435007757 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 479435007758 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 479435007759 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 479435007760 substrate binding site [chemical binding]; other site 479435007761 hinge regions; other site 479435007762 ADP binding site [chemical binding]; other site 479435007763 catalytic site [active] 479435007764 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 479435007765 substrate binding site [chemical binding]; other site 479435007766 dimer interface [polypeptide binding]; other site 479435007767 catalytic triad [active] 479435007768 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 479435007769 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435007770 tetramer interface [polypeptide binding]; other site 479435007771 active site 479435007772 Mg2+/Mn2+ binding site [ion binding]; other site 479435007773 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435007774 active site 479435007775 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 479435007776 putative active site [active] 479435007777 opcA protein; Region: OpcA; TIGR00534 479435007778 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 479435007779 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 479435007780 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479435007781 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479435007782 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: Pgi; COG0166 479435007783 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435007784 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435007785 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 479435007786 putative active site [active] 479435007787 transaldolase; Provisional; Region: PRK03903 479435007788 catalytic residue [active] 479435007789 transketolase; Reviewed; Region: PRK05899 479435007790 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 479435007791 TPP-binding site [chemical binding]; other site 479435007792 dimer interface [polypeptide binding]; other site 479435007793 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479435007794 PYR/PP interface [polypeptide binding]; other site 479435007795 dimer interface [polypeptide binding]; other site 479435007796 TPP binding site [chemical binding]; other site 479435007797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435007798 UbiA prenyltransferase family; Region: UbiA; cl00337 479435007799 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 479435007800 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435007801 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435007802 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435007803 Walker A/P-loop; other site 479435007804 ATP binding site [chemical binding]; other site 479435007805 Q-loop/lid; other site 479435007806 ABC transporter signature motif; other site 479435007807 Walker B; other site 479435007808 D-loop; other site 479435007809 H-loop/switch region; other site 479435007810 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435007811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435007812 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 479435007813 FeS assembly protein SufB; Region: sufB; TIGR01980 479435007814 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 479435007815 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 479435007816 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 479435007817 [2Fe-2S] cluster binding site [ion binding]; other site 479435007818 FeS assembly ATPase SufC; Region: sufC; TIGR01978 479435007819 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 479435007820 Walker A/P-loop; other site 479435007821 ATP binding site [chemical binding]; other site 479435007822 Q-loop/lid; other site 479435007823 ABC transporter signature motif; other site 479435007824 Walker B; other site 479435007825 D-loop; other site 479435007826 H-loop/switch region; other site 479435007827 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435007828 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 479435007829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007830 catalytic residue [active] 479435007831 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 479435007832 trimerization site [polypeptide binding]; other site 479435007833 active site 479435007834 Domain of unknown function DUF59; Region: DUF59; cl00941 479435007835 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 479435007836 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 479435007837 ATP binding site [chemical binding]; other site 479435007838 Walker A motif; other site 479435007839 hexamer interface [polypeptide binding]; other site 479435007840 Walker B motif; other site 479435007841 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 479435007842 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 479435007843 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479435007844 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435007845 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435007846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007847 Walker A/P-loop; other site 479435007848 ATP binding site [chemical binding]; other site 479435007849 Q-loop/lid; other site 479435007850 ABC transporter signature motif; other site 479435007851 Walker B; other site 479435007852 D-loop; other site 479435007853 H-loop/switch region; other site 479435007854 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435007855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435007856 substrate binding site [chemical binding]; other site 479435007857 oxyanion hole (OAH) forming residues; other site 479435007858 trimer interface [polypeptide binding]; other site 479435007859 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435007860 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 479435007861 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435007862 Walker A/P-loop; other site 479435007863 ATP binding site [chemical binding]; other site 479435007864 Q-loop/lid; other site 479435007865 ABC transporter signature motif; other site 479435007866 Walker B; other site 479435007867 D-loop; other site 479435007868 H-loop/switch region; other site 479435007869 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 479435007870 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435007871 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435007872 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 479435007873 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 479435007874 carboxyltransferase (CT) interaction site; other site 479435007875 biotinylation site [posttranslational modification]; other site 479435007876 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 479435007877 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435007878 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 479435007879 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 479435007880 active site 479435007881 DNA binding site [nucleotide binding] 479435007882 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 479435007883 DNA binding site [nucleotide binding] 479435007884 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435007885 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435007886 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435007887 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435007888 phosphopeptide binding site; other site 479435007889 Phosphotransferase enzyme family; Region: APH; pfam01636 479435007890 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435007891 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 479435007892 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435007893 putative NAD(P) binding site [chemical binding]; other site 479435007894 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435007895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435007896 active site 479435007897 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435007898 catalytic tetrad [active] 479435007899 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 479435007900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007901 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 479435007902 Phosphotransferase enzyme family; Region: APH; pfam01636 479435007903 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (...; Region: APH; cd05150 479435007904 active site 479435007905 ATP binding site [chemical binding]; other site 479435007906 antibiotic binding site [chemical binding]; other site 479435007907 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435007908 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 479435007909 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 479435007910 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 479435007911 putative active site [active] 479435007912 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 479435007913 putative active site [active] 479435007914 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 479435007915 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 479435007916 G1 box; other site 479435007917 putative GEF interaction site [polypeptide binding]; other site 479435007918 GTP/Mg2+ binding site [chemical binding]; other site 479435007919 Switch I region; other site 479435007920 G2 box; other site 479435007921 CysD dimerization site [polypeptide binding]; other site 479435007922 G3 box; other site 479435007923 Switch II region; other site 479435007924 G4 box; other site 479435007925 G5 box; other site 479435007926 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 479435007927 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 479435007928 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435007929 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435007930 Active Sites [active] 479435007931 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435007932 Active Sites [active] 479435007933 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 479435007934 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435007935 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435007936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435007937 dimerization interface [polypeptide binding]; other site 479435007938 putative DNA binding site [nucleotide binding]; other site 479435007939 putative Zn2+ binding site [ion binding]; other site 479435007940 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007941 serine hydroxymethyltransferase; Provisional; Region: PRK13580 479435007942 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 479435007943 dimer interface [polypeptide binding]; other site 479435007944 glycine-pyridoxal phosphate binding site [chemical binding]; other site 479435007945 active site 479435007946 folate binding site [chemical binding]; other site 479435007947 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 479435007948 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435007949 active site 479435007950 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 479435007951 GTPase RsgA; Reviewed; Region: PRK01889 479435007952 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 479435007953 GTPase/OB domain interface [polypeptide binding]; other site 479435007954 GTPase/Zn-binding domain interface [polypeptide binding]; other site 479435007955 GTP/Mg2+ binding site [chemical binding]; other site 479435007956 G4 box; other site 479435007957 G5 box; other site 479435007958 G1 box; other site 479435007959 Switch I region; other site 479435007960 G2 box; other site 479435007961 G3 box; other site 479435007962 Switch II region; other site 479435007963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435007964 classical (c) SDRs; Region: SDR_c; cd05233 479435007965 NAD(P) binding site [chemical binding]; other site 479435007966 active site 479435007967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435007968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435007969 ATP binding site [chemical binding]; other site 479435007970 putative Mg++ binding site [ion binding]; other site 479435007971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435007972 Flavoprotein; Region: Flavoprotein; cl08021 479435007973 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 479435007974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435007975 non-specific DNA binding site [nucleotide binding]; other site 479435007976 salt bridge; other site 479435007977 sequence-specific DNA binding site [nucleotide binding]; other site 479435007978 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 479435007979 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435007980 nucleotide binding site [chemical binding]; other site 479435007981 polymerase nucleotide-binding site; other site 479435007982 primase nucleotide-binding site [nucleotide binding]; other site 479435007983 DNA-binding residues [nucleotide binding]; DNA binding site 479435007984 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 479435007985 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435007986 integrase; Provisional; Region: int; PHA02601 479435007987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435007988 DNA binding site [nucleotide binding] 479435007989 Int/Topo IB signature motif; other site 479435007990 active site 479435007991 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435007992 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435007993 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 479435007994 Aminotransferase class IV; Region: Aminotran_4; pfam01063 479435007995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435007996 catalytic residue [active] 479435007997 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435007998 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 479435007999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435008000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008001 NAD(P) binding site [chemical binding]; other site 479435008002 active site 479435008003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008004 DNA-binding site [nucleotide binding]; DNA binding site 479435008005 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435008006 ligand binding site [chemical binding]; other site 479435008007 dimerization interface [polypeptide binding]; other site 479435008008 Histidine kinase; Region: HisKA_3; pfam07730 479435008009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435008010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435008011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435008012 active site 479435008013 phosphorylation site [posttranslational modification] 479435008014 intermolecular recognition site; other site 479435008015 dimerization interface [polypeptide binding]; other site 479435008016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435008017 DNA binding residues [nucleotide binding] 479435008018 dimerization interface [polypeptide binding]; other site 479435008019 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 479435008020 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479435008021 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435008022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435008023 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 479435008024 Walker A/P-loop; other site 479435008025 ATP binding site [chemical binding]; other site 479435008026 Q-loop/lid; other site 479435008027 ABC transporter signature motif; other site 479435008028 Walker B; other site 479435008029 D-loop; other site 479435008030 H-loop/switch region; other site 479435008031 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 479435008032 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 479435008033 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 479435008034 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 479435008035 active site 479435008036 dimer interface [polypeptide binding]; other site 479435008037 motif 1; other site 479435008038 motif 2; other site 479435008039 motif 3; other site 479435008040 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 479435008041 anticodon binding site; other site 479435008042 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 479435008043 nucleotide binding site/active site [active] 479435008044 HIT family signature motif; other site 479435008045 catalytic residue [active] 479435008046 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435008047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 479435008048 putative acyl-acceptor binding pocket; other site 479435008049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435008050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435008051 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435008052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435008054 DNA binding residues [nucleotide binding] 479435008055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435008056 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 479435008057 HIT family signature motif; other site 479435008058 catalytic residue [active] 479435008059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435008060 binding surface 479435008061 TPR motif; other site 479435008062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435008063 TPR motif; other site 479435008064 binding surface 479435008065 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1223 479435008066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435008067 Walker A motif; other site 479435008068 ATP binding site [chemical binding]; other site 479435008069 Walker B motif; other site 479435008070 arginine finger; other site 479435008071 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 479435008072 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435008073 putative NAD(P) binding site [chemical binding]; other site 479435008074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008075 dimerization interface [polypeptide binding]; other site 479435008076 putative DNA binding site [nucleotide binding]; other site 479435008077 putative Zn2+ binding site [ion binding]; other site 479435008078 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 479435008079 elongation factor G; Reviewed; Region: PRK12740 479435008080 G1 box; other site 479435008081 putative GEF interaction site [polypeptide binding]; other site 479435008082 GTP/Mg2+ binding site [chemical binding]; other site 479435008083 Switch I region; other site 479435008084 G2 box; other site 479435008085 G3 box; other site 479435008086 Switch II region; other site 479435008087 G4 box; other site 479435008088 G5 box; other site 479435008089 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 479435008090 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 479435008091 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 479435008092 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435008093 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 479435008094 DNA binding residues [nucleotide binding] 479435008095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435008096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435008097 Phage integrase family; Region: Phage_integrase; pfam00589 479435008098 Int/Topo IB signature motif; other site 479435008099 active site 479435008100 DNA binding site [nucleotide binding] 479435008101 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435008102 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435008103 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 479435008104 Ferritin-like domain; Region: Ferritin; pfam00210 479435008105 ferroxidase diiron center [ion binding]; other site 479435008106 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 479435008107 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435008108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008109 PAC2 family; Region: PAC2; cl00847 479435008110 DoxX; Region: DoxX; cl00976 479435008111 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 479435008112 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 479435008113 active site 479435008114 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 479435008115 catalytic triad [active] 479435008116 dimer interface [polypeptide binding]; other site 479435008117 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 479435008118 active site 479435008119 dimer interface [polypeptide binding]; other site 479435008120 motif 1; other site 479435008121 motif 2; other site 479435008122 motif 3; other site 479435008123 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 479435008124 anticodon binding site; other site 479435008125 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479435008126 active site 2 [active] 479435008127 active site 1 [active] 479435008128 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 479435008129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008130 NAD(P) binding site [chemical binding]; other site 479435008131 active site 479435008132 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 479435008133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435008134 dimer interface [polypeptide binding]; other site 479435008135 active site 479435008136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435008137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435008139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435008140 active site 479435008141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008142 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435008143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435008144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008145 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435008146 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435008147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008148 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435008149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008150 S-adenosylmethionine binding site [chemical binding]; other site 479435008151 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 479435008152 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 479435008153 active site 479435008154 DNA binding site [nucleotide binding] 479435008155 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 479435008156 DNA binding site [nucleotide binding] 479435008157 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479435008158 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 479435008159 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435008160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008161 catalytic residue [active] 479435008162 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435008163 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479435008164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435008165 motif II; other site 479435008166 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 479435008167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008168 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435008169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435008170 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435008171 putative sugar binding sites [chemical binding]; other site 479435008172 Q-X-W motif; other site 479435008173 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 479435008174 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435008175 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 479435008176 putative active site [active] 479435008177 putative DNA binding site [nucleotide binding]; other site 479435008178 putative phosphate binding site [ion binding]; other site 479435008179 putative catalytic site [active] 479435008180 metal binding site A [ion binding]; metal-binding site 479435008181 putative AP binding site [nucleotide binding]; other site 479435008182 putative metal binding site B [ion binding]; other site 479435008183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435008184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008185 short chain dehydrogenase; Provisional; Region: PRK07825 479435008186 classical (c) SDRs; Region: SDR_c; cd05233 479435008187 NAD(P) binding site [chemical binding]; other site 479435008188 active site 479435008189 Uncharacterized conserved protein [Function unknown]; Region: COG3268 479435008190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008191 short chain dehydrogenase; Validated; Region: PRK05855 479435008192 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435008193 hypothetical protein; Provisional; Region: PRK11770 479435008194 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479435008195 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479435008196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435008197 Amidinotransferase; Region: Amidinotransf; cl12043 479435008198 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 479435008199 DNA polymerase IV; Provisional; Region: PRK03348 479435008200 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435008201 active site 479435008202 DNA binding site [nucleotide binding] 479435008203 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435008204 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479435008205 Ligand Binding Site [chemical binding]; other site 479435008206 uncharacterized HhH-GPD family protein; Region: TIGR03252 479435008207 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435008208 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 479435008209 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 479435008210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008211 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435008212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435008213 DNA binding residues [nucleotide binding] 479435008214 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 479435008215 Beta-lactamase; Region: Beta-lactamase; cl01009 479435008216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008217 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435008218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008219 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 479435008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008221 S-adenosylmethionine binding site [chemical binding]; other site 479435008222 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435008223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435008224 dimer interface [polypeptide binding]; other site 479435008225 phosphorylation site [posttranslational modification] 479435008226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435008227 ATP binding site [chemical binding]; other site 479435008228 Mg2+ binding site [ion binding]; other site 479435008229 G-X-G motif; other site 479435008230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435008231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435008232 active site 479435008233 phosphorylation site [posttranslational modification] 479435008234 intermolecular recognition site; other site 479435008235 dimerization interface [polypeptide binding]; other site 479435008236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435008237 DNA binding site [nucleotide binding] 479435008238 Protein of unknown function (DUF456); Region: DUF456; cl01069 479435008239 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 479435008240 LysE type translocator; Region: LysE; cl00565 479435008241 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435008242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008243 DNA-binding site [nucleotide binding]; DNA binding site 479435008244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435008245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008246 homodimer interface [polypeptide binding]; other site 479435008247 catalytic residue [active] 479435008248 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 479435008249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435008250 ATP binding site [chemical binding]; other site 479435008251 Mg2+ binding site [ion binding]; other site 479435008252 G-X-G motif; other site 479435008253 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 479435008254 ATP binding site [chemical binding]; other site 479435008255 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 479435008256 active site 479435008257 metal binding site [ion binding]; metal-binding site 479435008258 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 479435008259 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479435008260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435008261 motif II; other site 479435008262 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 479435008263 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 479435008264 active site clefts [active] 479435008265 zinc binding site [ion binding]; other site 479435008266 dimer interface [polypeptide binding]; other site 479435008267 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 479435008268 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 479435008269 active site clefts [active] 479435008270 zinc binding site [ion binding]; other site 479435008271 dimer interface [polypeptide binding]; other site 479435008272 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435008273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008274 putative substrate translocation pore; other site 479435008275 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 479435008276 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 479435008277 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 479435008278 CAP-like domain; other site 479435008279 Active site [active] 479435008280 primary dimer interface [polypeptide binding]; other site 479435008281 FtsX-like permease family; Region: FtsX; pfam02687 479435008282 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435008283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435008284 Walker A/P-loop; other site 479435008285 ATP binding site [chemical binding]; other site 479435008286 Q-loop/lid; other site 479435008287 ABC transporter signature motif; other site 479435008288 Walker B; other site 479435008289 D-loop; other site 479435008290 H-loop/switch region; other site 479435008291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435008292 Histidine kinase; Region: HisKA_3; pfam07730 479435008293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435008294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435008295 active site 479435008296 phosphorylation site [posttranslational modification] 479435008297 intermolecular recognition site; other site 479435008298 dimerization interface [polypeptide binding]; other site 479435008299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435008300 DNA binding residues [nucleotide binding] 479435008301 dimerization interface [polypeptide binding]; other site 479435008302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008303 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435008304 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 479435008305 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 479435008306 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 479435008307 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435008308 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435008309 transmembrane helices; other site 479435008310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008311 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479435008312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435008314 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 479435008315 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435008316 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435008317 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 479435008318 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 479435008319 putative active site pocket [active] 479435008320 cleavage site 479435008321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435008322 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435008323 Walker A/P-loop; other site 479435008324 ATP binding site [chemical binding]; other site 479435008325 Q-loop/lid; other site 479435008326 ABC transporter signature motif; other site 479435008327 Walker B; other site 479435008328 D-loop; other site 479435008329 H-loop/switch region; other site 479435008330 Sulfatase; Region: Sulfatase; cl10460 479435008331 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435008332 active site 479435008333 catalytic residues [active] 479435008334 Thymidine kinase; Region: TK; cl00631 479435008335 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479435008336 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 479435008337 active site residue [active] 479435008338 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479435008339 active site residue [active] 479435008340 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435008341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435008342 Coenzyme A binding pocket [chemical binding]; other site 479435008343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008344 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435008345 putative dimerization interface [polypeptide binding]; other site 479435008346 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435008347 catalytic residue [active] 479435008348 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479435008349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435008350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435008351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435008352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008353 dimer interface [polypeptide binding]; other site 479435008354 conserved gate region; other site 479435008355 putative PBP binding loops; other site 479435008356 ABC-ATPase subunit interface; other site 479435008357 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435008358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008359 dimer interface [polypeptide binding]; other site 479435008360 conserved gate region; other site 479435008361 putative PBP binding loops; other site 479435008362 ABC-ATPase subunit interface; other site 479435008363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435008364 extended (e) SDRs; Region: SDR_e; cd08946 479435008365 NAD(P) binding site [chemical binding]; other site 479435008366 active site 479435008367 substrate binding site [chemical binding]; other site 479435008368 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435008369 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 479435008370 metal binding site [ion binding]; metal-binding site 479435008371 substrate binding pocket [chemical binding]; other site 479435008372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008373 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435008374 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435008375 classical (c) SDRs; Region: SDR_c; cd05233 479435008376 NAD(P) binding site [chemical binding]; other site 479435008377 active site 479435008378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435008379 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435008380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435008383 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435008384 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435008385 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435008386 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 479435008387 Erythromycin esterase; Region: Erythro_esteras; pfam05139 479435008388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008390 NAD(P) binding site [chemical binding]; other site 479435008391 active site 479435008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008393 NmrA-like family; Region: NmrA; pfam05368 479435008394 NAD(P) binding site [chemical binding]; other site 479435008395 active site 479435008396 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 479435008397 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435008398 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435008399 Zn binding site [ion binding]; other site 479435008400 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 479435008401 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435008402 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435008403 active site 479435008404 catalytic tetrad [active] 479435008405 Protein of unknown function (DUF328); Region: DUF328; cl01143 479435008406 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 479435008407 Predicted transcriptional regulators [Transcription]; Region: COG1378 479435008408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008409 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435008410 EamA-like transporter family; Region: EamA; cl01037 479435008411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435008412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008413 DNA-binding site [nucleotide binding]; DNA binding site 479435008414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435008415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008416 homodimer interface [polypeptide binding]; other site 479435008417 catalytic residue [active] 479435008418 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435008419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008420 putative substrate translocation pore; other site 479435008421 Rhomboid family; Region: Rhomboid; cl11446 479435008422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435008423 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435008424 Walker A/P-loop; other site 479435008425 ATP binding site [chemical binding]; other site 479435008426 Q-loop/lid; other site 479435008427 ABC transporter signature motif; other site 479435008428 Walker B; other site 479435008429 D-loop; other site 479435008430 H-loop/switch region; other site 479435008431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435008432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435008433 active site 479435008434 phosphorylation site [posttranslational modification] 479435008435 intermolecular recognition site; other site 479435008436 dimerization interface [polypeptide binding]; other site 479435008437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435008438 DNA binding site [nucleotide binding] 479435008439 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 479435008440 dimerization interface [polypeptide binding]; other site 479435008441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 479435008442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435008443 ATP binding site [chemical binding]; other site 479435008444 Mg2+ binding site [ion binding]; other site 479435008445 G-X-G motif; other site 479435008446 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 479435008447 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 479435008448 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479435008449 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 479435008450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008451 catalytic residue [active] 479435008452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435008453 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479435008454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008455 NAD(P) binding site [chemical binding]; other site 479435008456 active site 479435008457 OsmC-like protein; Region: OsmC; cl00767 479435008458 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 479435008459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008460 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435008461 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435008462 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479435008463 nucleoside/Zn binding site; other site 479435008464 dimer interface [polypeptide binding]; other site 479435008465 catalytic motif [active] 479435008466 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435008467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008468 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435008469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008470 S-adenosylmethionine binding site [chemical binding]; other site 479435008471 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435008472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008473 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435008474 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435008475 active site 479435008476 catalytic tetrad [active] 479435008477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008478 S-adenosylmethionine binding site [chemical binding]; other site 479435008479 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 479435008480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008481 S-adenosylmethionine binding site [chemical binding]; other site 479435008482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435008483 putative dimer interface [polypeptide binding]; other site 479435008484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435008485 Phage integrase family; Region: Phage_integrase; pfam00589 479435008486 DNA binding site [nucleotide binding] 479435008487 Int/Topo IB signature motif; other site 479435008488 active site 479435008489 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 479435008490 nucleotide binding site [chemical binding]; other site 479435008491 substrate binding site [chemical binding]; other site 479435008492 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 479435008493 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 479435008494 G1 box; other site 479435008495 putative GEF interaction site [polypeptide binding]; other site 479435008496 GTP/Mg2+ binding site [chemical binding]; other site 479435008497 Switch I region; other site 479435008498 G2 box; other site 479435008499 G3 box; other site 479435008500 Switch II region; other site 479435008501 G4 box; other site 479435008502 G5 box; other site 479435008503 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 479435008504 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684 479435008505 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to...; Region: Elongation_Factor_C; cl02785 479435008506 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435008507 active site 479435008508 metal binding site [ion binding]; metal-binding site 479435008509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435008511 YCII-related domain; Region: YCII; cl00999 479435008512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435008513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008514 dimer interface [polypeptide binding]; other site 479435008515 conserved gate region; other site 479435008516 putative PBP binding loops; other site 479435008517 ABC-ATPase subunit interface; other site 479435008518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008519 dimer interface [polypeptide binding]; other site 479435008520 conserved gate region; other site 479435008521 putative PBP binding loops; other site 479435008522 ABC-ATPase subunit interface; other site 479435008523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435008524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435008525 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435008526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435008527 DNA binding site [nucleotide binding] 479435008528 domain linker motif; other site 479435008529 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435008530 dimerization interface [polypeptide binding]; other site 479435008531 ligand binding site [chemical binding]; other site 479435008532 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435008533 classical (c) SDRs; Region: SDR_c; cd05233 479435008534 NAD(P) binding site [chemical binding]; other site 479435008535 active site 479435008536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008538 Walker A/P-loop; other site 479435008539 ATP binding site [chemical binding]; other site 479435008540 Q-loop/lid; other site 479435008541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008542 ABC transporter signature motif; other site 479435008543 Walker B; other site 479435008544 D-loop; other site 479435008545 H-loop/switch region; other site 479435008546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008547 Walker A/P-loop; other site 479435008548 ATP binding site [chemical binding]; other site 479435008549 Q-loop/lid; other site 479435008550 ABC transporter signature motif; other site 479435008551 Walker B; other site 479435008552 D-loop; other site 479435008553 H-loop/switch region; other site 479435008554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008556 NAD(P) binding site [chemical binding]; other site 479435008557 active site 479435008558 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 479435008559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008560 DNA-binding site [nucleotide binding]; DNA binding site 479435008561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435008562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008563 homodimer interface [polypeptide binding]; other site 479435008564 catalytic residue [active] 479435008565 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435008566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435008567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008568 catalytic residue [active] 479435008569 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435008570 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435008571 putative hydrophobic ligand binding site [chemical binding]; other site 479435008572 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435008573 hydrophobic ligand binding site; other site 479435008574 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435008575 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435008576 active site 479435008577 Zn binding site [ion binding]; other site 479435008578 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435008579 active site 479435008580 catalytic triad [active] 479435008581 oxyanion hole [active] 479435008582 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435008583 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 479435008584 Walker A/P-loop; other site 479435008585 ATP binding site [chemical binding]; other site 479435008586 Q-loop/lid; other site 479435008587 ABC transporter signature motif; other site 479435008588 Walker B; other site 479435008589 D-loop; other site 479435008590 H-loop/switch region; other site 479435008591 Cobalt transport protein; Region: CbiQ; cl00463 479435008592 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 479435008593 cobalt transport protein CbiN; Validated; Region: PRK06287 479435008594 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435008595 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 479435008596 active site 479435008597 metal binding site [ion binding]; metal-binding site 479435008598 hexamer interface [polypeptide binding]; other site 479435008599 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 479435008600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435008603 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 479435008604 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435008605 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435008606 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 479435008607 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 479435008608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435008609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008610 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 479435008611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008612 hypothetical protein; Provisional; Region: PRK07588 479435008613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008614 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435008615 Cupin domain; Region: Cupin_2; cl09118 479435008616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435008617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435008618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435008619 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435008620 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 479435008621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435008622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435008623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435008624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008625 dimer interface [polypeptide binding]; other site 479435008626 putative PBP binding loops; other site 479435008627 ABC-ATPase subunit interface; other site 479435008628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008629 dimer interface [polypeptide binding]; other site 479435008630 conserved gate region; other site 479435008631 putative PBP binding loops; other site 479435008632 ABC-ATPase subunit interface; other site 479435008633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435008634 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 479435008635 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 479435008636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435008637 active site 479435008638 enoyl-CoA hydratase; Provisional; Region: PRK06144 479435008639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435008640 substrate binding site [chemical binding]; other site 479435008641 oxyanion hole (OAH) forming residues; other site 479435008642 trimer interface [polypeptide binding]; other site 479435008643 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435008644 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435008645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435008646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435008647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008648 dimer interface [polypeptide binding]; other site 479435008649 conserved gate region; other site 479435008650 putative PBP binding loops; other site 479435008651 ABC-ATPase subunit interface; other site 479435008652 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435008653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435008654 dimer interface [polypeptide binding]; other site 479435008655 putative PBP binding loops; other site 479435008656 ABC-ATPase subunit interface; other site 479435008657 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435008658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008659 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435008660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008661 DNA-binding site [nucleotide binding]; DNA binding site 479435008662 FCD domain; Region: FCD; cl11656 479435008663 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435008664 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435008665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008666 catalytic residue [active] 479435008667 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 479435008668 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435008669 putative active site [active] 479435008670 catalytic site [active] 479435008671 putative metal binding site [ion binding]; other site 479435008672 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 479435008673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008674 putative substrate translocation pore; other site 479435008675 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 479435008676 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 479435008677 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 479435008678 putative active site [active] 479435008679 catalytic triad [active] 479435008680 putative dimer interface [polypeptide binding]; other site 479435008681 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479435008682 active site 2 [active] 479435008683 active site 1 [active] 479435008684 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 479435008685 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 479435008686 B12 binding site [chemical binding]; other site 479435008687 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 479435008688 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 479435008689 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 479435008690 active site 479435008691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435008692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435008693 S-adenosylmethionine binding site [chemical binding]; other site 479435008694 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435008695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008696 5'-3' exonuclease; Region: 53EXOc; smart00475 479435008697 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479435008698 active site 479435008699 metal binding site 1 [ion binding]; metal-binding site 479435008700 putative 5' ssDNA interaction site; other site 479435008701 metal binding site 3; metal-binding site 479435008702 metal binding site 2 [ion binding]; metal-binding site 479435008703 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479435008704 putative DNA binding site [nucleotide binding]; other site 479435008705 putative metal binding site [ion binding]; other site 479435008706 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 479435008707 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 479435008708 metal binding site [ion binding]; metal-binding site 479435008709 dimer interface [polypeptide binding]; other site 479435008710 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435008711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435008713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435008714 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435008715 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 479435008716 Walker A/P-loop; other site 479435008717 ATP binding site [chemical binding]; other site 479435008718 Q-loop/lid; other site 479435008719 ABC transporter signature motif; other site 479435008720 Walker B; other site 479435008721 D-loop; other site 479435008722 H-loop/switch region; other site 479435008723 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435008724 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435008725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008726 Walker A/P-loop; other site 479435008727 ATP binding site [chemical binding]; other site 479435008728 Q-loop/lid; other site 479435008729 ABC transporter signature motif; other site 479435008730 Walker B; other site 479435008731 D-loop; other site 479435008732 H-loop/switch region; other site 479435008733 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 479435008734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008736 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435008737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435008738 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435008739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008740 Walker A/P-loop; other site 479435008741 ATP binding site [chemical binding]; other site 479435008742 Q-loop/lid; other site 479435008743 ABC transporter signature motif; other site 479435008744 Walker B; other site 479435008745 D-loop; other site 479435008746 H-loop/switch region; other site 479435008747 SNF2 Helicase protein; Region: DUF3670; pfam12419 479435008748 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479435008749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435008750 ATP binding site [chemical binding]; other site 479435008751 putative Mg++ binding site [ion binding]; other site 479435008752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435008753 nucleotide binding region [chemical binding]; other site 479435008754 ATP-binding site [chemical binding]; other site 479435008755 Uncharacterized conserved protein [Function unknown]; Region: COG4279 479435008756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008757 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435008758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008759 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 479435008760 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435008761 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435008762 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 479435008763 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 479435008764 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 479435008765 active site 479435008766 homodimer interface [polypeptide binding]; other site 479435008767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435008768 Coenzyme A binding pocket [chemical binding]; other site 479435008769 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435008770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435008771 dimer interface [polypeptide binding]; other site 479435008772 phosphorylation site [posttranslational modification] 479435008773 Recombination activating protein 2; Region: RAG2; pfam03089 479435008774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435008775 ATP binding site [chemical binding]; other site 479435008776 Mg2+ binding site [ion binding]; other site 479435008777 G-X-G motif; other site 479435008778 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 479435008779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435008780 active site 479435008781 phosphorylation site [posttranslational modification] 479435008782 intermolecular recognition site; other site 479435008783 dimerization interface [polypeptide binding]; other site 479435008784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435008785 DNA binding site [nucleotide binding] 479435008786 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 479435008787 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479435008788 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435008789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008790 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 479435008791 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435008792 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435008793 cyclase homology domain; Region: CHD; cd07302 479435008794 nucleotidyl binding site; other site 479435008795 metal binding site [ion binding]; metal-binding site 479435008796 dimer interface [polypeptide binding]; other site 479435008797 short chain dehydrogenase; Provisional; Region: PRK06123 479435008798 classical (c) SDRs; Region: SDR_c; cd05233 479435008799 NAD(P) binding site [chemical binding]; other site 479435008800 active site 479435008801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008802 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 479435008803 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435008804 putative NAD(P) binding site [chemical binding]; other site 479435008805 putative active site [active] 479435008806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008807 dimerization interface [polypeptide binding]; other site 479435008808 putative DNA binding site [nucleotide binding]; other site 479435008809 putative Zn2+ binding site [ion binding]; other site 479435008810 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 479435008811 putative hydrophobic ligand binding site [chemical binding]; other site 479435008812 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435008813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435008814 ATP binding site [chemical binding]; other site 479435008815 putative Mg++ binding site [ion binding]; other site 479435008816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435008817 nucleotide binding region [chemical binding]; other site 479435008818 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 479435008819 ATP-binding site [chemical binding]; other site 479435008820 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435008821 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 479435008822 DNA binding residues [nucleotide binding] 479435008823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435008825 putative substrate translocation pore; other site 479435008826 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435008827 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435008828 conserved cys residue [active] 479435008829 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 479435008830 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 479435008831 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 479435008832 active site 479435008833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435008834 short chain dehydrogenase; Provisional; Region: PRK05866 479435008835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008836 NAD(P) binding site [chemical binding]; other site 479435008837 active site 479435008838 acyl-CoA synthetase; Validated; Region: PRK07788 479435008839 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435008840 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 479435008841 active site 479435008842 citrylCoA binding site [chemical binding]; other site 479435008843 oxalacetate binding site [chemical binding]; other site 479435008844 coenzyme A binding site [chemical binding]; other site 479435008845 catalytic triad [active] 479435008846 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435008847 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435008848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008849 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435008850 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435008851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 479435008852 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435008853 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 479435008854 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 479435008855 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 479435008856 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 479435008857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435008858 ATP binding site [chemical binding]; other site 479435008859 putative Mg++ binding site [ion binding]; other site 479435008860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008861 Helicase associated domain (HA2); Region: HA2; cl04503 479435008862 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 479435008863 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 479435008864 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435008865 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 479435008866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435008867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435008868 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435008869 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435008870 active site 479435008871 metal binding site [ion binding]; metal-binding site 479435008872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435008873 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within...; Region: GH20_SpHex_like; cd06568 479435008874 active site 479435008875 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 479435008876 DNA-binding site [nucleotide binding]; DNA binding site 479435008877 RNA-binding motif; other site 479435008878 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435008879 BCCT family transporter; Region: BCCT; cl00569 479435008880 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435008881 Strictosidine synthase; Region: Str_synth; pfam03088 479435008882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435008884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435008885 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479435008886 Walker A motif; other site 479435008887 ATP binding site [chemical binding]; other site 479435008888 Walker B motif; other site 479435008889 arginine finger; other site 479435008890 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 479435008891 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435008892 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 479435008893 active site 479435008894 catalytic residues [active] 479435008895 metal binding site [ion binding]; metal-binding site 479435008896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435008897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435008898 DNA binding site [nucleotide binding] 479435008899 domain linker motif; other site 479435008900 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435008901 dimerization interface [polypeptide binding]; other site 479435008902 ligand binding site [chemical binding]; other site 479435008903 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435008904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008905 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435008906 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435008907 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 479435008908 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435008909 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 479435008910 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 479435008911 putative dimer interface [polypeptide binding]; other site 479435008912 active site pocket [active] 479435008913 putative cataytic base [active] 479435008914 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 479435008915 substrate binding site [chemical binding]; other site 479435008916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435008917 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 479435008918 substrate binding site [chemical binding]; other site 479435008919 oxyanion hole (OAH) forming residues; other site 479435008920 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435008921 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435008922 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 479435008923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435008924 dimer interface [polypeptide binding]; other site 479435008925 active site 479435008926 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435008927 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435008928 DNA binding residues [nucleotide binding] 479435008929 dimer interface [polypeptide binding]; other site 479435008930 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435008931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435008932 TM-ABC transporter signature motif; other site 479435008933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008934 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435008935 Walker A/P-loop; other site 479435008936 ATP binding site [chemical binding]; other site 479435008937 Q-loop/lid; other site 479435008938 ABC transporter signature motif; other site 479435008939 Walker B; other site 479435008940 D-loop; other site 479435008941 H-loop/switch region; other site 479435008942 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435008943 putative ligand binding site [chemical binding]; other site 479435008944 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 479435008945 FAD binding pocket [chemical binding]; other site 479435008946 FAD binding motif [chemical binding]; other site 479435008947 phosphate binding motif [ion binding]; other site 479435008948 beta-alpha-beta structure motif; other site 479435008949 NAD binding pocket [chemical binding]; other site 479435008950 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 479435008951 Moco binding site; other site 479435008952 metal coordination site [ion binding]; other site 479435008953 Archaeal ATPase; Region: Arch_ATPase; pfam01637 479435008954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435008955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435008956 active site 479435008957 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435008958 DinB superfamily; Region: DinB_2; cl00986 479435008959 cobyric acid synthase; Provisional; Region: PRK00784 479435008960 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435008961 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 479435008962 catalytic triad [active] 479435008963 benzoate transport; Region: 2A0115; TIGR00895 479435008964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008965 putative substrate translocation pore; other site 479435008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435008967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008968 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-...; Region: PA2301; cd04939 479435008969 putative deacylase active site [active] 479435008970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435008971 OsmC-like protein; Region: OsmC; cl00767 479435008972 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435008973 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 479435008974 NAD(P) binding site [chemical binding]; other site 479435008975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008976 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435008977 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 479435008978 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435008979 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479435008980 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 479435008981 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 479435008982 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479435008983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435008984 Walker A/P-loop; other site 479435008985 ATP binding site [chemical binding]; other site 479435008986 Q-loop/lid; other site 479435008987 ABC transporter signature motif; other site 479435008988 Walker B; other site 479435008989 D-loop; other site 479435008990 H-loop/switch region; other site 479435008991 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435008992 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 479435008993 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479435008994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435008995 motif II; other site 479435008996 amino-acid N-acetyltransferase; Region: PLN02825 479435008997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435008998 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 479435008999 active site 479435009000 catalytic residues [active] 479435009001 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435009002 metal binding site [ion binding]; metal-binding site 479435009003 ligand binding site [chemical binding]; other site 479435009004 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 479435009005 proposed catalytic triad [active] 479435009006 active site nucleophile [active] 479435009007 cyanophycin synthetase; Provisional; Region: PRK14016 479435009008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435009009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435009010 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435009011 Protein of unknown function (DUF461); Region: DUF461; cl01071 479435009012 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 479435009013 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479435009014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435009015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435009016 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 479435009017 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 479435009018 NAD binding site [chemical binding]; other site 479435009019 homotetramer interface [polypeptide binding]; other site 479435009020 homodimer interface [polypeptide binding]; other site 479435009021 substrate binding site [chemical binding]; other site 479435009022 active site 479435009023 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 479435009024 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435009025 NAD(P) binding site [chemical binding]; other site 479435009026 homotetramer interface [polypeptide binding]; other site 479435009027 homodimer interface [polypeptide binding]; other site 479435009028 active site 479435009029 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 479435009030 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 479435009031 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 479435009032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435009033 FeS/SAM binding site; other site 479435009034 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 479435009035 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 479435009036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009037 NAD(P) binding site [chemical binding]; other site 479435009038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435009039 active site 479435009040 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435009041 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 479435009042 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 479435009043 nucleotide binding site [chemical binding]; other site 479435009044 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435009045 active site 479435009046 Zn binding site [ion binding]; other site 479435009047 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 479435009048 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 479435009049 generic binding surface I; other site 479435009050 generic binding surface II; other site 479435009051 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435009052 putative catalytic site [active] 479435009053 putative metal binding site [ion binding]; other site 479435009054 putative phosphate binding site [ion binding]; other site 479435009055 SelR domain; Region: SelR; cl00369 479435009056 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435009057 active site 479435009058 Chlorite dismutase; Region: Chlor_dismutase; cl01280 479435009059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009060 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 479435009061 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 479435009062 substrate binding site [chemical binding]; other site 479435009063 active site 479435009064 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 479435009065 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 479435009066 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 479435009067 putative active site [active] 479435009068 catalytic site [active] 479435009069 putative substrate binding site [chemical binding]; other site 479435009070 HRDC domain; Region: HRDC; cl02578 479435009071 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 479435009072 catalytic residues [active] 479435009073 dimer interface [polypeptide binding]; other site 479435009074 Dienelactone hydrolase family; Region: DLH; pfam01738 479435009075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435009076 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 479435009077 dimer interface [polypeptide binding]; other site 479435009078 active site 479435009079 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479435009080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435009081 substrate binding site [chemical binding]; other site 479435009082 oxyanion hole (OAH) forming residues; other site 479435009083 trimer interface [polypeptide binding]; other site 479435009084 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435009085 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435009086 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 479435009087 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435009088 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 479435009089 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 479435009090 TPP-binding site; other site 479435009091 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479435009092 PYR/PP interface [polypeptide binding]; other site 479435009093 dimer interface [polypeptide binding]; other site 479435009094 TPP binding site [chemical binding]; other site 479435009095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435009096 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 479435009097 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 479435009098 NAD binding site [chemical binding]; other site 479435009099 substrate binding site [chemical binding]; other site 479435009100 homodimer interface [polypeptide binding]; other site 479435009101 active site 479435009102 Protein of unknown function (DUF402); Region: DUF402; cl00979 479435009103 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 479435009104 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 479435009105 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 479435009106 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 479435009107 nucleotide binding site/active site [active] 479435009108 HIT family signature motif; other site 479435009109 catalytic residue [active] 479435009110 YCII-related domain; Region: YCII; cl00999 479435009111 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435009112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435009113 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435009114 DinB superfamily; Region: DinB_2; cl00986 479435009115 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 479435009116 active site 479435009117 aconitate hydratase; Validated; Region: PRK09277 479435009118 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479435009119 substrate binding site [chemical binding]; other site 479435009120 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479435009121 ligand binding site [chemical binding]; other site 479435009122 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 479435009123 substrate binding site [chemical binding]; other site 479435009124 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435009125 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435009126 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 479435009127 TRAM domain; Region: TRAM; cl01282 479435009128 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 479435009129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435009130 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435009131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009132 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435009133 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435009134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009135 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435009136 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 479435009137 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 479435009138 generic binding surface II; other site 479435009139 ssDNA binding site; other site 479435009140 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 479435009141 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 479435009142 trimer interface [polypeptide binding]; other site 479435009143 active site 479435009144 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 479435009145 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435009146 active site 479435009147 dimerization interface [polypeptide binding]; other site 479435009148 ferrochelatase; Reviewed; Region: hemH; PRK00035 479435009149 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 479435009150 C-terminal domain interface [polypeptide binding]; other site 479435009151 active site 479435009152 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 479435009153 active site 479435009154 N-terminal domain interface [polypeptide binding]; other site 479435009155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009156 Predicted membrane protein [Function unknown]; Region: COG2860 479435009157 UPF0126 domain; Region: UPF0126; pfam03458 479435009158 UPF0126 domain; Region: UPF0126; pfam03458 479435009159 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435009160 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 479435009161 active site 479435009162 catalytic residues [active] 479435009163 metal binding site [ion binding]; metal-binding site 479435009164 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 479435009165 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 479435009166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435009168 DNA binding residues [nucleotide binding] 479435009169 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 479435009170 Anti-sigma-K factor rskA; Region: RskA; cl02208 479435009171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009172 Uncharacterized conserved protein [Function unknown]; Region: COG4717 479435009173 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 479435009174 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 479435009175 active site 479435009176 metal binding site [ion binding]; metal-binding site 479435009177 DNA binding site [nucleotide binding] 479435009178 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435009179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435009180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435009181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435009182 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435009183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435009184 DNA binding residues [nucleotide binding] 479435009185 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435009186 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435009187 Walker A/P-loop; other site 479435009188 ATP binding site [chemical binding]; other site 479435009189 Q-loop/lid; other site 479435009190 ABC transporter signature motif; other site 479435009191 Walker B; other site 479435009192 D-loop; other site 479435009193 H-loop/switch region; other site 479435009194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435009195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435009196 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435009197 Walker A/P-loop; other site 479435009198 ATP binding site [chemical binding]; other site 479435009199 Q-loop/lid; other site 479435009200 ABC transporter signature motif; other site 479435009201 Walker B; other site 479435009202 D-loop; other site 479435009203 H-loop/switch region; other site 479435009204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435009205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435009206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435009207 dimer interface [polypeptide binding]; other site 479435009208 conserved gate region; other site 479435009209 putative PBP binding loops; other site 479435009210 ABC-ATPase subunit interface; other site 479435009211 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 479435009212 peptide binding site [polypeptide binding]; other site 479435009213 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435009214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435009215 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435009217 dimer interface [polypeptide binding]; other site 479435009218 conserved gate region; other site 479435009219 putative PBP binding loops; other site 479435009220 ABC-ATPase subunit interface; other site 479435009221 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 479435009222 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435009223 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 479435009224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435009225 active site 479435009226 motif I; other site 479435009227 motif II; other site 479435009228 PAC2 family; Region: PAC2; cl00847 479435009229 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435009230 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435009231 DNA binding residues [nucleotide binding] 479435009232 putative dimer interface [polypeptide binding]; other site 479435009233 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 479435009234 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435009235 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435009236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009237 NAD(P) binding site [chemical binding]; other site 479435009238 active site 479435009239 Cupin domain; Region: Cupin_2; cl09118 479435009240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435009241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435009242 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479435009243 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 479435009244 active site 479435009245 HIGH motif; other site 479435009246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435009247 active site 479435009248 KMSKS motif; other site 479435009249 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435009250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009251 NAD(P) binding site [chemical binding]; other site 479435009252 active site 479435009253 Cupin domain; Region: Cupin_2; cl09118 479435009254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435009255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435009256 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 479435009257 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 479435009258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435009259 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435009260 catalytic core [active] 479435009261 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435009262 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 479435009263 Bacitracin resistance protein BacA; Region: BacA; cl00858 479435009264 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 479435009265 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435009266 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435009267 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435009268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435009269 active site 479435009270 catalytic tetrad [active] 479435009271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435009272 ATP binding site [chemical binding]; other site 479435009273 putative Mg++ binding site [ion binding]; other site 479435009274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435009275 nucleotide binding region [chemical binding]; other site 479435009276 ATP-binding site [chemical binding]; other site 479435009277 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 479435009278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435009280 hypothetical protein; Provisional; Region: PRK07906 479435009281 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 479435009282 putative metal binding site [ion binding]; other site 479435009283 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435009284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435009285 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 479435009286 hydrophobic ligand binding site; other site 479435009287 Cytochrome P450; Region: p450; cl12078 479435009288 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435009289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009290 short chain dehydrogenase; Provisional; Region: PRK06181 479435009291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009292 NAD(P) binding site [chemical binding]; other site 479435009293 active site 479435009294 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 479435009295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009296 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 479435009297 Glyco_18 domain; Region: Glyco_18; smart00636 479435009298 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435009299 active site 479435009300 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435009301 putative sugar binding sites [chemical binding]; other site 479435009302 Q-X-W motif; other site 479435009303 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435009304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009305 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435009306 active site 479435009307 catalytic triad [active] 479435009308 oxyanion hole [active] 479435009309 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435009310 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435009311 putative sugar binding sites [chemical binding]; other site 479435009312 Q-X-W motif; other site 479435009313 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435009314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435009315 dimerization interface [polypeptide binding]; other site 479435009316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435009317 GAF domain; Region: GAF; cl00853 479435009318 ANTAR domain; Region: ANTAR; cl04297 479435009319 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 479435009320 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 479435009321 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 479435009322 FAD binding pocket [chemical binding]; other site 479435009323 FAD binding motif [chemical binding]; other site 479435009324 phosphate binding motif [ion binding]; other site 479435009325 beta-alpha-beta structure motif; other site 479435009326 NAD binding pocket [chemical binding]; other site 479435009327 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435009328 catalytic loop [active] 479435009329 iron binding site [ion binding]; other site 479435009330 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 479435009331 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 479435009332 putative di-iron ligands [ion binding]; other site 479435009333 ANTAR domain; Region: ANTAR; cl04297 479435009334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009335 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435009336 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 479435009337 ANTAR domain; Region: ANTAR; cl04297 479435009338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009339 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 479435009340 putative active site [active] 479435009341 putative metal binding site [ion binding]; other site 479435009342 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435009343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435009344 DNA-binding site [nucleotide binding]; DNA binding site 479435009345 UTRA domain; Region: UTRA; cl01230 479435009346 Phosphate transporter family; Region: PHO4; cl00396 479435009347 Phytase; Region: Phytase; pfam02333 479435009348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435009349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435009350 dimer interface [polypeptide binding]; other site 479435009351 conserved gate region; other site 479435009352 putative PBP binding loops; other site 479435009353 ABC-ATPase subunit interface; other site 479435009354 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435009355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435009356 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435009357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009358 Walker A/P-loop; other site 479435009359 ATP binding site [chemical binding]; other site 479435009360 Q-loop/lid; other site 479435009361 ABC transporter signature motif; other site 479435009362 Walker B; other site 479435009363 D-loop; other site 479435009364 H-loop/switch region; other site 479435009365 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435009366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435009367 motif II; other site 479435009368 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435009369 active site 479435009370 dimerization interface [polypeptide binding]; other site 479435009371 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435009372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435009373 active site 479435009374 motif I; other site 479435009375 motif II; other site 479435009376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435009377 GAF domain; Region: GAF; cl00853 479435009378 ANTAR domain; Region: ANTAR; cl04297 479435009379 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 479435009380 chlorophyllide a oxygenase; Region: PLN02281 479435009381 iron-sulfur cluster [ion binding]; other site 479435009382 [2Fe-2S] cluster binding site [ion binding]; other site 479435009383 Uncharacterized conserved protein [Function unknown]; Region: COG3349 479435009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435009386 S-adenosylmethionine binding site [chemical binding]; other site 479435009387 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479435009388 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479435009389 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 479435009390 active site lid residues [active] 479435009391 substrate binding pocket [chemical binding]; other site 479435009392 catalytic residues [active] 479435009393 substrate-Mg2+ binding site; other site 479435009394 aspartate-rich region 1; other site 479435009395 aspartate-rich region 2; other site 479435009396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009397 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435009398 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435009399 substrate binding pocket [chemical binding]; other site 479435009400 chain length determination region; other site 479435009401 substrate-Mg2+ binding site; other site 479435009402 catalytic residues [active] 479435009403 aspartate-rich region 1; other site 479435009404 active site lid residues [active] 479435009405 aspartate-rich region 2; other site 479435009406 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435009407 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 479435009408 heme bH binding site [chemical binding]; other site 479435009409 Qi binding site; other site 479435009410 intrachain domain interface; other site 479435009411 heme bL binding site [chemical binding]; other site 479435009412 interchain domain interface [polypeptide binding]; other site 479435009413 Qo binding site; other site 479435009414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009415 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 479435009416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009417 NAD(P) binding pocket [chemical binding]; other site 479435009418 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435009419 YCII-related domain; Region: YCII; cl00999 479435009420 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435009421 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435009422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009423 putative substrate translocation pore; other site 479435009424 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435009425 homodimer interface [polypeptide binding]; other site 479435009426 active site 479435009427 TDP-binding site; other site 479435009428 acceptor substrate-binding pocket; other site 479435009429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435009431 putative substrate translocation pore; other site 479435009432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435009433 S-adenosylmethionine binding site [chemical binding]; other site 479435009434 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479435009435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435009436 non-specific DNA binding site [nucleotide binding]; other site 479435009437 salt bridge; other site 479435009438 sequence-specific DNA binding site [nucleotide binding]; other site 479435009439 Cupin domain; Region: Cupin_2; cl09118 479435009440 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435009441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435009443 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435009444 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435009445 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479435009446 Active site [active] 479435009447 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 479435009448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009449 putative DNA binding site [nucleotide binding]; other site 479435009450 putative Zn2+ binding site [ion binding]; other site 479435009451 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 479435009452 division inhibitor protein; Provisional; Region: slmA; PRK09480 479435009453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009456 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435009457 DinB superfamily; Region: DinB_2; cl00986 479435009458 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435009459 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435009460 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435009461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009462 dimerization interface [polypeptide binding]; other site 479435009463 putative DNA binding site [nucleotide binding]; other site 479435009464 putative Zn2+ binding site [ion binding]; other site 479435009465 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435009466 anti sigma factor interaction site; other site 479435009467 regulatory phosphorylation site [posttranslational modification]; other site 479435009468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435009470 active site 479435009471 phosphorylation site [posttranslational modification] 479435009472 intermolecular recognition site; other site 479435009473 dimerization interface [polypeptide binding]; other site 479435009474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435009475 DNA binding site [nucleotide binding] 479435009476 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435009477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 479435009478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435009479 ATP binding site [chemical binding]; other site 479435009480 Mg2+ binding site [ion binding]; other site 479435009481 G-X-G motif; other site 479435009482 Sporulation and spore germination; Region: Germane; cl11253 479435009483 Carboxylesterase family; Region: COesterase; pfam00135 479435009484 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435009485 substrate binding pocket [chemical binding]; other site 479435009486 catalytic triad [active] 479435009487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009488 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435009489 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 479435009490 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 479435009491 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435009492 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435009493 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435009494 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435009495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435009496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009497 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 479435009498 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 479435009499 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435009500 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 479435009501 putative dimer interface [polypeptide binding]; other site 479435009502 ligand binding site [chemical binding]; other site 479435009503 Zn binding site [ion binding]; other site 479435009504 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435009505 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435009506 active site 479435009507 catalytic site [active] 479435009508 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435009509 dinuclear metal binding motif [ion binding]; other site 479435009510 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435009511 dinuclear metal binding motif [ion binding]; other site 479435009512 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435009513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435009515 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 479435009516 dimanganese center [ion binding]; other site 479435009517 Flavin Reductases; Region: FlaRed; cl00801 479435009518 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435009519 YCII-related domain; Region: YCII; cl00999 479435009520 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 479435009521 Cupin domain; Region: Cupin_2; cl09118 479435009522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435009523 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 479435009524 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 479435009525 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435009526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009527 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435009528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009529 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435009530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009531 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 479435009532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435009533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009534 short chain dehydrogenase; Provisional; Region: PRK08219 479435009535 classical (c) SDRs; Region: SDR_c; cd05233 479435009536 NAD(P) binding site [chemical binding]; other site 479435009537 active site 479435009538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435009540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435009541 active site 479435009542 ATP binding site [chemical binding]; other site 479435009543 substrate binding site [chemical binding]; other site 479435009544 activation loop (A-loop); other site 479435009545 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 479435009546 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 479435009547 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435009548 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 479435009549 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 479435009550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435009551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435009552 DNA binding site [nucleotide binding] 479435009553 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 479435009554 ligand binding site [chemical binding]; other site 479435009555 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435009556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009557 putative substrate translocation pore; other site 479435009558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435009559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435009560 DNA binding site [nucleotide binding] 479435009561 domain linker motif; other site 479435009562 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435009563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435009564 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435009565 putative metal binding site [ion binding]; other site 479435009566 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435009567 putative catalytic site [active] 479435009568 putative phosphate binding site [ion binding]; other site 479435009569 putative metal binding site [ion binding]; other site 479435009570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009571 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435009572 putative dimerization interface [polypeptide binding]; other site 479435009573 EamA-like transporter family; Region: EamA; cl01037 479435009574 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 479435009575 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 479435009576 putative NAD(P) binding site [chemical binding]; other site 479435009577 putative substrate binding site [chemical binding]; other site 479435009578 catalytic Zn binding site [ion binding]; other site 479435009579 structural Zn binding site [ion binding]; other site 479435009580 dimer interface [polypeptide binding]; other site 479435009581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435009584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009585 Walker A/P-loop; other site 479435009586 ATP binding site [chemical binding]; other site 479435009587 Q-loop/lid; other site 479435009588 ABC transporter signature motif; other site 479435009589 Walker B; other site 479435009590 D-loop; other site 479435009591 H-loop/switch region; other site 479435009592 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 479435009593 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435009594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435009595 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435009596 active site 479435009597 metal binding site [ion binding]; metal-binding site 479435009598 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479435009599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435009600 motif II; other site 479435009601 methionine aminopeptidase; Reviewed; Region: PRK07281 479435009602 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435009603 active site 479435009604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435009605 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 479435009606 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 479435009607 nucleotide binding pocket [chemical binding]; other site 479435009608 K-X-D-G motif; other site 479435009609 catalytic site [active] 479435009610 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 479435009611 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 479435009612 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 479435009613 Dimer interface [polypeptide binding]; other site 479435009614 BRCT sequence motif; other site 479435009615 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 479435009616 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 479435009617 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 479435009618 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 479435009619 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479435009620 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479435009621 Glucose dehydrogenase; Region: glucose_DH; cd08230 479435009622 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435009623 NADP binding site [chemical binding]; other site 479435009624 catalytic Zn binding site [ion binding]; other site 479435009625 structural Zn binding site [ion binding]; other site 479435009626 dimer interface [polypeptide binding]; other site 479435009627 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435009628 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435009629 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 479435009630 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435009631 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 479435009632 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 479435009633 generic binding surface II; other site 479435009634 generic binding surface I; other site 479435009635 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 479435009636 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435009637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435009638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435009639 dimer interface [polypeptide binding]; other site 479435009640 conserved gate region; other site 479435009641 ABC-ATPase subunit interface; other site 479435009642 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435009643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435009644 putative PBP binding loops; other site 479435009645 dimer interface [polypeptide binding]; other site 479435009646 ABC-ATPase subunit interface; other site 479435009647 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435009648 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 479435009649 Walker A/P-loop; other site 479435009650 ATP binding site [chemical binding]; other site 479435009651 Q-loop/lid; other site 479435009652 ABC transporter signature motif; other site 479435009653 Walker B; other site 479435009654 D-loop; other site 479435009655 H-loop/switch region; other site 479435009656 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435009657 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435009658 Walker A/P-loop; other site 479435009659 ATP binding site [chemical binding]; other site 479435009660 Q-loop/lid; other site 479435009661 ABC transporter signature motif; other site 479435009662 Walker B; other site 479435009663 D-loop; other site 479435009664 H-loop/switch region; other site 479435009665 Cupin domain; Region: Cupin_2; cl09118 479435009666 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435009667 DNA binding residues [nucleotide binding] 479435009668 dimer interface [polypeptide binding]; other site 479435009669 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435009670 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479435009671 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 479435009672 putative dimer interface [polypeptide binding]; other site 479435009673 DinB superfamily; Region: DinB_2; cl00986 479435009674 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435009675 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435009676 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435009677 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435009678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435009679 DNA binding residues [nucleotide binding] 479435009680 dimerization interface [polypeptide binding]; other site 479435009681 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 479435009682 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435009683 Walker A/P-loop; other site 479435009684 ATP binding site [chemical binding]; other site 479435009685 Q-loop/lid; other site 479435009686 ABC transporter signature motif; other site 479435009687 Walker B; other site 479435009688 D-loop; other site 479435009689 H-loop/switch region; other site 479435009690 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435009691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435009692 ATP binding site [chemical binding]; other site 479435009693 putative Mg++ binding site [ion binding]; other site 479435009694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435009695 nucleotide binding region [chemical binding]; other site 479435009696 ATP-binding site [chemical binding]; other site 479435009697 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 479435009698 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435009699 DNA binding site [nucleotide binding] 479435009700 Int/Topo IB signature motif; other site 479435009701 active site 479435009702 oxidoreductase; Provisional; Region: PRK06196 479435009703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009704 NAD(P) binding site [chemical binding]; other site 479435009705 active site 479435009706 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435009707 tetramer interface [polypeptide binding]; other site 479435009708 active site 479435009709 Mg2+/Mn2+ binding site [ion binding]; other site 479435009710 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435009711 active site 479435009712 metal binding site [ion binding]; metal-binding site 479435009713 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435009714 putative hydrophobic ligand binding site [chemical binding]; other site 479435009715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009716 Coenzyme A binding pocket [chemical binding]; other site 479435009717 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479435009718 active site 479435009719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435009720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009721 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 479435009722 active site 479435009723 catalytic triad [active] 479435009724 oxyanion hole [active] 479435009725 LysE type translocator; Region: LysE; cl00565 479435009726 enolase; Provisional; Region: eno; PRK00077 479435009727 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 479435009728 dimer interface [polypeptide binding]; other site 479435009729 metal binding site [ion binding]; metal-binding site 479435009730 substrate binding pocket [chemical binding]; other site 479435009731 Beta-lactamase; Region: Beta-lactamase; cl01009 479435009732 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 479435009733 DNA binding residues [nucleotide binding] 479435009734 dimer interface [polypeptide binding]; other site 479435009735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435009736 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435009737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435009739 DNA binding residues [nucleotide binding] 479435009740 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435009741 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435009742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009743 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479435009744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435009746 dimerization interface [polypeptide binding]; other site 479435009747 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 479435009748 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435009749 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 479435009750 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 479435009751 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435009752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009753 catalytic residue [active] 479435009754 Cupin domain; Region: Cupin_2; cl09118 479435009755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435009756 YCII-related domain; Region: YCII; cl00999 479435009757 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435009758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435009760 argininosuccinate lyase; Provisional; Region: PRK02186 479435009761 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435009762 cystathionine gamma-lyase; Validated; Region: PRK07582 479435009763 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435009764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009765 catalytic residue [active] 479435009766 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 479435009767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009770 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 479435009771 active site 479435009772 Zn-binding site [ion binding]; other site 479435009773 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435009774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009775 amidase; Provisional; Region: PRK07869 479435009776 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435009777 putative transcriptional regulator; Provisional; Region: PRK11640 479435009778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009781 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435009782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435009784 classical (c) SDRs; Region: SDR_c; cd05233 479435009785 NAD(P) binding site [chemical binding]; other site 479435009786 active site 479435009787 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435009788 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 479435009789 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 479435009790 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 479435009791 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435009792 RHS Repeat; Region: RHS_repeat; cl11982 479435009793 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435009794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009795 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435009796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435009797 DNA binding residues [nucleotide binding] 479435009798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435009799 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435009800 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435009801 LysE type translocator; Region: LysE; cl00565 479435009802 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435009803 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435009804 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435009805 active site 479435009806 catalytic site [active] 479435009807 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 479435009808 starch-binding site 2 [chemical binding]; other site 479435009809 starch-binding site 1 [chemical binding]; other site 479435009810 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435009811 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435009812 active site 479435009813 catalytic site [active] 479435009814 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435009815 putative metal binding site [ion binding]; other site 479435009816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009817 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435009818 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435009819 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435009820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009821 Predicted ATPase [General function prediction only]; Region: COG3899 479435009822 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479435009823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435009824 DNA binding residues [nucleotide binding] 479435009825 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 479435009826 ANTAR domain; Region: ANTAR; cl04297 479435009827 Fasciclin domain; Region: Fasciclin; cl02663 479435009828 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435009829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435009830 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 479435009831 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 479435009832 putative active site [active] 479435009833 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435009834 active site 479435009835 ATP binding site [chemical binding]; other site 479435009836 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 479435009837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009838 putative DNA binding helix; other site 479435009839 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435009840 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 479435009841 intersubunit interface [polypeptide binding]; other site 479435009842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 479435009843 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479435009844 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 479435009845 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435009846 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 479435009847 putative ligand binding residues [chemical binding]; other site 479435009848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435009849 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435009850 Walker A/P-loop; other site 479435009851 ATP binding site [chemical binding]; other site 479435009852 Q-loop/lid; other site 479435009853 ABC transporter signature motif; other site 479435009854 Walker B; other site 479435009855 D-loop; other site 479435009856 H-loop/switch region; other site 479435009857 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 479435009858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435009859 ABC-ATPase subunit interface; other site 479435009860 dimer interface [polypeptide binding]; other site 479435009861 putative PBP binding regions; other site 479435009862 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 479435009863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435009864 S-adenosylmethionine binding site [chemical binding]; other site 479435009865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435009866 S-adenosylmethionine binding site [chemical binding]; other site 479435009867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435009868 active site 479435009869 catalytic tetrad [active] 479435009870 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 479435009871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009872 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435009873 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435009874 tetratricopeptide repeat protein; Provisional; Region: PRK11788 479435009875 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435009876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009877 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435009878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009879 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009881 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435009882 NAD(P) binding site [chemical binding]; other site 479435009883 active site 479435009884 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 479435009885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435009886 putative NAD(P) binding site [chemical binding]; other site 479435009887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435009888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009889 NAD(P) binding site [chemical binding]; other site 479435009890 active site 479435009891 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435009892 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435009893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009895 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435009896 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435009897 putative NAD(P) binding site [chemical binding]; other site 479435009898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435009899 Cytochrome P450; Region: p450; cl12078 479435009900 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 479435009901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435009902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009903 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 479435009904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009906 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435009907 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435009908 active site 479435009909 catalytic tetrad [active] 479435009910 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435009911 classical (c) SDRs; Region: SDR_c; cd05233 479435009912 NAD(P) binding site [chemical binding]; other site 479435009913 active site 479435009914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009916 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435009917 MbtH-like protein; Region: MbtH; cl01279 479435009918 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435009919 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009920 Condensation domain; Region: Condensation; cl09290 479435009921 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435009922 peptide synthase; Provisional; Region: PRK12316 479435009923 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009924 peptide synthase; Validated; Region: PRK05691 479435009925 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009926 Condensation domain; Region: Condensation; cl09290 479435009927 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435009928 Condensation domain; Region: Condensation; cl09290 479435009929 peptide synthase; Provisional; Region: PRK12467 479435009930 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435009932 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435009933 DNA binding residues [nucleotide binding] 479435009934 dimerization interface [polypeptide binding]; other site 479435009935 Condensation domain; Region: Condensation; cl09290 479435009936 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435009937 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 479435009938 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435009939 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009940 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435009942 non-specific DNA binding site [nucleotide binding]; other site 479435009943 salt bridge; other site 479435009944 sequence-specific DNA binding site [nucleotide binding]; other site 479435009945 Cytochrome P450; Region: p450; cl12078 479435009946 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435009947 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009948 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009950 NAD(P) binding site [chemical binding]; other site 479435009951 active site 479435009952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435009953 active site 479435009954 Condensation domain; Region: Condensation; cl09290 479435009955 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009956 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435009957 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009958 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 479435009959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435009960 hypothetical protein; Provisional; Region: PRK08912 479435009961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435009962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435009963 homodimer interface [polypeptide binding]; other site 479435009964 catalytic residue [active] 479435009965 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435009966 substrate binding site [chemical binding]; other site 479435009967 oxyanion hole (OAH) forming residues; other site 479435009968 trimer interface [polypeptide binding]; other site 479435009969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435009970 trimer interface [polypeptide binding]; other site 479435009971 oxyanion hole (OAH) forming residues; other site 479435009972 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 479435009973 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435009974 active site 479435009975 enoyl-CoA hydratase; Provisional; Region: PRK06494 479435009976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435009977 substrate binding site [chemical binding]; other site 479435009978 oxyanion hole (OAH) forming residues; other site 479435009979 trimer interface [polypeptide binding]; other site 479435009980 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 479435009981 Glutamine amidotransferase class-I; Region: GATase; pfam00117 479435009982 glutamine binding [chemical binding]; other site 479435009983 catalytic triad [active] 479435009984 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 479435009985 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435009986 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435009987 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 479435009988 Condensation domain; Region: Condensation; cl09290 479435009989 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435009990 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435009991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009992 peptide synthase; Provisional; Region: PRK12467 479435009993 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435009995 Condensation domain; Region: Condensation; cl09290 479435009996 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435009997 Nonribosomal peptide synthase; Region: NRPS; pfam08415 479435009998 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435009999 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435010000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435010001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435010002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 479435010003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010004 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435010005 active site 479435010006 catalytic tetrad [active] 479435010007 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 479435010008 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 479435010009 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 479435010010 ligand-binding site [chemical binding]; other site 479435010011 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435010012 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435010013 Active Sites [active] 479435010014 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 479435010015 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 479435010016 G1 box; other site 479435010017 putative GEF interaction site [polypeptide binding]; other site 479435010018 GTP/Mg2+ binding site [chemical binding]; other site 479435010019 Switch I region; other site 479435010020 G2 box; other site 479435010021 CysD dimerization site [polypeptide binding]; other site 479435010022 G3 box; other site 479435010023 Switch II region; other site 479435010024 G4 box; other site 479435010025 G5 box; other site 479435010026 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 479435010027 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 479435010028 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435010029 active site 479435010030 ATP binding site [chemical binding]; other site 479435010031 Phosphotransferase enzyme family; Region: APH; pfam01636 479435010032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010033 putative substrate translocation pore; other site 479435010034 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 479435010035 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 479435010036 [4Fe-4S] binding site [ion binding]; other site 479435010037 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 479435010038 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 479435010039 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 479435010040 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 479435010041 molybdopterin cofactor binding site; other site 479435010042 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 479435010043 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 479435010044 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 479435010045 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 479435010046 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 479435010047 Uncharacterized conserved protein [Function unknown]; Region: COG2850 479435010048 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479435010049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435010051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010054 DNA binding site [nucleotide binding] 479435010055 domain linker motif; other site 479435010056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435010057 ligand binding site [chemical binding]; other site 479435010058 dimerization interface [polypeptide binding]; other site 479435010059 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435010060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010062 dimer interface [polypeptide binding]; other site 479435010063 conserved gate region; other site 479435010064 ABC-ATPase subunit interface; other site 479435010065 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435010066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010067 dimer interface [polypeptide binding]; other site 479435010068 conserved gate region; other site 479435010069 putative PBP binding loops; other site 479435010070 ABC-ATPase subunit interface; other site 479435010071 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 479435010072 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435010073 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 479435010074 domain; Region: Glyco_hydro_2; pfam00703 479435010075 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 479435010076 Copper resistance protein CopC; Region: CopC; cl01012 479435010077 Copper resistance protein D; Region: CopD; cl00563 479435010078 FixH; Region: FixH; cl01254 479435010079 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 479435010080 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435010081 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435010082 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 479435010083 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 479435010084 VCBS repeat; Region: VCBS_repeat; TIGR01965 479435010085 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435010086 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435010087 NAD(P) binding site [chemical binding]; other site 479435010088 catalytic residues [active] 479435010089 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435010090 TM-ABC transporter signature motif; other site 479435010091 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435010092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435010093 Walker A/P-loop; other site 479435010094 ATP binding site [chemical binding]; other site 479435010095 Q-loop/lid; other site 479435010096 ABC transporter signature motif; other site 479435010097 Walker B; other site 479435010098 D-loop; other site 479435010099 H-loop/switch region; other site 479435010100 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435010101 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435010102 TM-ABC transporter signature motif; other site 479435010103 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435010104 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479435010105 ligand binding site [chemical binding]; other site 479435010106 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 479435010107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010108 NAD(P) binding site [chemical binding]; other site 479435010109 active site 479435010110 KduI/IolB family; Region: KduI; cl01508 479435010111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010112 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435010113 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435010114 LGFP repeat; Region: LGFP; pfam08310 479435010115 LGFP repeat; Region: LGFP; pfam08310 479435010116 LGFP repeat; Region: LGFP; pfam08310 479435010117 CHAT domain; Region: CHAT; cl02083 479435010118 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 479435010119 active site 479435010120 catalytic residues [active] 479435010121 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435010122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010124 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435010125 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 479435010126 metal binding site [ion binding]; metal-binding site 479435010127 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435010128 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435010129 putative hydrophobic ligand binding site [chemical binding]; other site 479435010130 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435010131 Cupin domain; Region: Cupin_2; cl09118 479435010132 Beta-lactamase; Region: Beta-lactamase; cl01009 479435010133 NIPSNAP; Region: NIPSNAP; pfam07978 479435010134 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435010135 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435010136 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 479435010137 [2Fe-2S] cluster binding site [ion binding]; other site 479435010138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010139 active site 479435010140 metal binding site [ion binding]; metal-binding site 479435010141 Competence-damaged protein; Region: CinA; cl00666 479435010142 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 479435010143 dimanganese center [ion binding]; other site 479435010144 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479435010145 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479435010146 D-pathway; other site 479435010147 Putative ubiquinol binding site [chemical binding]; other site 479435010148 Low-spin heme (heme b) binding site [chemical binding]; other site 479435010149 Putative water exit pathway; other site 479435010150 Binuclear center (heme o3/CuB) [ion binding]; other site 479435010151 K-pathway; other site 479435010152 Putative proton exit pathway; other site 479435010153 ANTAR domain; Region: ANTAR; cl04297 479435010154 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435010155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435010157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010159 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435010160 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435010161 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435010162 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435010163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435010164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010166 dimer interface [polypeptide binding]; other site 479435010167 conserved gate region; other site 479435010168 putative PBP binding loops; other site 479435010169 ABC-ATPase subunit interface; other site 479435010170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010171 dimer interface [polypeptide binding]; other site 479435010172 conserved gate region; other site 479435010173 putative PBP binding loops; other site 479435010174 ABC-ATPase subunit interface; other site 479435010175 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 479435010176 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 479435010177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010178 putative substrate translocation pore; other site 479435010179 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435010180 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 479435010181 NAD(P) binding site [chemical binding]; other site 479435010182 catalytic residues [active] 479435010183 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435010184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435010185 non-specific DNA binding site [nucleotide binding]; other site 479435010186 salt bridge; other site 479435010187 sequence-specific DNA binding site [nucleotide binding]; other site 479435010188 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435010189 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479435010190 putative NAD(P) binding site [chemical binding]; other site 479435010191 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435010192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010193 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435010194 Predicted ATPase [General function prediction only]; Region: COG3899 479435010195 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479435010196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010197 DNA binding residues [nucleotide binding] 479435010198 dimerization interface [polypeptide binding]; other site 479435010199 LytB protein; Region: LYTB; cl00507 479435010200 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 479435010201 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435010202 substrate binding pocket [chemical binding]; other site 479435010203 chain length determination region; other site 479435010204 substrate-Mg2+ binding site; other site 479435010205 catalytic residues [active] 479435010206 aspartate-rich region 1; other site 479435010207 active site lid residues [active] 479435010208 aspartate-rich region 2; other site 479435010209 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 479435010210 substrate binding pocket [chemical binding]; other site 479435010211 substrate-Mg2+ binding site; other site 479435010212 aspartate-rich region 1; other site 479435010213 aspartate-rich region 2; other site 479435010214 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 479435010215 substrate binding pocket [chemical binding]; other site 479435010216 substrate-Mg2+ binding site; other site 479435010217 aspartate-rich region 1; other site 479435010218 aspartate-rich region 2; other site 479435010219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435010220 ligand binding site [chemical binding]; other site 479435010221 flexible hinge region; other site 479435010222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435010223 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435010224 Walker A/P-loop; other site 479435010225 ATP binding site [chemical binding]; other site 479435010226 Q-loop/lid; other site 479435010227 ABC transporter signature motif; other site 479435010228 Walker B; other site 479435010229 D-loop; other site 479435010230 H-loop/switch region; other site 479435010231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435010232 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435010233 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435010234 Walker A/P-loop; other site 479435010235 ATP binding site [chemical binding]; other site 479435010236 Q-loop/lid; other site 479435010237 ABC transporter signature motif; other site 479435010238 Walker B; other site 479435010239 D-loop; other site 479435010240 H-loop/switch region; other site 479435010241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435010242 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435010243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435010244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435010245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010246 dimer interface [polypeptide binding]; other site 479435010247 conserved gate region; other site 479435010248 putative PBP binding loops; other site 479435010249 ABC-ATPase subunit interface; other site 479435010250 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 479435010251 substrate binding site [chemical binding]; other site 479435010252 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435010253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435010254 S-adenosylmethionine binding site [chemical binding]; other site 479435010255 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435010256 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435010257 HSP90 family protein; Provisional; Region: PRK14083 479435010258 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 479435010259 putative FMN binding site [chemical binding]; other site 479435010260 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435010261 hydrophobic ligand binding site; other site 479435010262 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435010263 active site 479435010264 metal binding site [ion binding]; metal-binding site 479435010265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010266 dimerization interface [polypeptide binding]; other site 479435010267 putative DNA binding site [nucleotide binding]; other site 479435010268 putative Zn2+ binding site [ion binding]; other site 479435010269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435010270 YCII-related domain; Region: YCII; cl00999 479435010271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010274 DNA binding site [nucleotide binding] 479435010275 domain linker motif; other site 479435010276 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435010277 putative dimerization interface [polypeptide binding]; other site 479435010278 putative ligand binding site [chemical binding]; other site 479435010279 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435010280 sugar binding site [chemical binding]; other site 479435010281 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 479435010282 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 479435010283 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435010284 sugar binding site [chemical binding]; other site 479435010285 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 479435010286 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435010287 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 479435010288 Metal-binding active site; metal-binding site 479435010289 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 479435010290 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435010291 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 479435010292 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435010293 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435010294 ligand binding site [chemical binding]; other site 479435010295 metal binding site [ion binding]; metal-binding site 479435010296 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 479435010297 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 479435010298 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 479435010299 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 479435010300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435010301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010302 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435010303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435010304 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435010305 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435010306 TM-ABC transporter signature motif; other site 479435010307 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435010308 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 479435010309 Walker A/P-loop; other site 479435010310 ATP binding site [chemical binding]; other site 479435010311 Q-loop/lid; other site 479435010312 ABC transporter signature motif; other site 479435010313 Walker B; other site 479435010314 D-loop; other site 479435010315 H-loop/switch region; other site 479435010316 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 479435010317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010318 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435010319 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435010320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010322 active site 479435010323 phosphorylation site [posttranslational modification] 479435010324 intermolecular recognition site; other site 479435010325 dimerization interface [polypeptide binding]; other site 479435010326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010327 DNA binding residues [nucleotide binding] 479435010328 dimerization interface [polypeptide binding]; other site 479435010329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435010330 Histidine kinase; Region: HisKA_3; pfam07730 479435010331 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435010332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010333 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435010334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435010335 YCII-related domain; Region: YCII; cl00999 479435010336 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 479435010337 active site 479435010338 catalytic triad [active] 479435010339 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435010340 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 479435010341 active site 479435010342 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 479435010343 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435010344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010345 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435010346 Histidine kinase; Region: HisKA_3; pfam07730 479435010347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435010348 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 479435010349 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435010350 active site 479435010351 substrate binding site [chemical binding]; other site 479435010352 FMN binding site [chemical binding]; other site 479435010353 putative catalytic residues [active] 479435010354 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435010355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435010356 DNA-binding site [nucleotide binding]; DNA binding site 479435010357 FCD domain; Region: FCD; cl11656 479435010358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435010359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435010360 Histidine kinase; Region: HisKA_3; pfam07730 479435010361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010363 active site 479435010364 phosphorylation site [posttranslational modification] 479435010365 intermolecular recognition site; other site 479435010366 dimerization interface [polypeptide binding]; other site 479435010367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010368 DNA binding residues [nucleotide binding] 479435010369 dimerization interface [polypeptide binding]; other site 479435010370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010372 active site 479435010373 phosphorylation site [posttranslational modification] 479435010374 intermolecular recognition site; other site 479435010375 dimerization interface [polypeptide binding]; other site 479435010376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010377 DNA binding residues [nucleotide binding] 479435010378 dimerization interface [polypeptide binding]; other site 479435010379 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435010380 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 479435010381 Walker A/P-loop; other site 479435010382 ATP binding site [chemical binding]; other site 479435010383 Q-loop/lid; other site 479435010384 ABC transporter signature motif; other site 479435010385 Walker B; other site 479435010386 D-loop; other site 479435010387 H-loop/switch region; other site 479435010388 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435010389 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 479435010390 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435010391 Uncharacterized conserved protein [Function unknown]; Region: COG3538 479435010392 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 479435010393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010394 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435010395 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435010396 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 479435010397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435010398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010399 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435010400 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435010401 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435010402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435010403 catalytic residue [active] 479435010404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010405 NmrA-like family; Region: NmrA; pfam05368 479435010406 NAD(P) binding site [chemical binding]; other site 479435010407 active site 479435010408 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435010409 EamA-like transporter family; Region: EamA; cl01037 479435010410 Protein of unknown function, DUF606; Region: DUF606; cl01273 479435010411 16S rRNA methyltransferase B; Provisional; Region: PRK14902 479435010412 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 479435010413 putative RNA binding site [nucleotide binding]; other site 479435010414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435010415 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 479435010416 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 479435010417 putative active site [active] 479435010418 substrate binding site [chemical binding]; other site 479435010419 putative cosubstrate binding site; other site 479435010420 catalytic site [active] 479435010421 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 479435010422 substrate binding site [chemical binding]; other site 479435010423 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 479435010424 active site 479435010425 catalytic residues [active] 479435010426 metal binding site [ion binding]; metal-binding site 479435010427 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479435010428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435010429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435010431 putative substrate translocation pore; other site 479435010432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010433 dimerization interface [polypeptide binding]; other site 479435010434 putative DNA binding site [nucleotide binding]; other site 479435010435 putative Zn2+ binding site [ion binding]; other site 479435010436 Putative cyclase; Region: Cyclase; cl00814 479435010437 primosome assembly protein PriA; Provisional; Region: PRK14873 479435010438 S-adenosylmethionine synthetase; Validated; Region: PRK05250 479435010439 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 479435010440 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 479435010441 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 479435010442 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435010443 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435010444 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435010445 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 479435010446 Flavoprotein; Region: Flavoprotein; cl08021 479435010447 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 479435010448 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 479435010449 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 479435010450 catalytic site [active] 479435010451 G-X2-G-X-G-K; other site 479435010452 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 479435010453 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 479435010454 active site 479435010455 dimer interface [polypeptide binding]; other site 479435010456 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 479435010457 quinone interaction residues [chemical binding]; other site 479435010458 active site 479435010459 catalytic residues [active] 479435010460 substrate binding site [chemical binding]; other site 479435010461 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435010462 phosphate binding site [ion binding]; other site 479435010463 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 479435010464 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435010465 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435010466 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 479435010467 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435010468 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435010469 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 479435010470 IMP binding site; other site 479435010471 dimer interface [polypeptide binding]; other site 479435010472 interdomain contacts; other site 479435010473 partial ornithine binding site; other site 479435010474 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 479435010475 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 479435010476 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 479435010477 catalytic site [active] 479435010478 subunit interface [polypeptide binding]; other site 479435010479 dihydroorotase; Validated; Region: pyrC; PRK09357 479435010480 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435010481 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 479435010482 active site 479435010483 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 479435010484 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479435010485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010486 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435010487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435010488 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 479435010489 putative RNA binding site [nucleotide binding]; other site 479435010490 elongation factor P; Validated; Region: PRK00529 479435010491 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 479435010492 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 479435010493 RNA binding site [nucleotide binding]; other site 479435010494 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 479435010495 RNA binding site [nucleotide binding]; other site 479435010496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435010497 S-adenosylmethionine binding site [chemical binding]; other site 479435010498 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435010499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010500 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435010501 EamA-like transporter family; Region: EamA; cl01037 479435010502 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010504 active site 479435010505 phosphorylation site [posttranslational modification] 479435010506 intermolecular recognition site; other site 479435010507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010508 DNA binding residues [nucleotide binding] 479435010509 dimerization interface [polypeptide binding]; other site 479435010510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435010511 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435010512 Carboxylesterase family; Region: COesterase; pfam00135 479435010513 substrate binding pocket [chemical binding]; other site 479435010514 catalytic triad [active] 479435010515 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 479435010516 trimer interface [polypeptide binding]; other site 479435010517 active site 479435010518 dimer interface [polypeptide binding]; other site 479435010519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010521 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435010522 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435010523 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435010524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435010525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435010526 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 479435010527 active site 479435010528 dimer interface [polypeptide binding]; other site 479435010529 metal binding site [ion binding]; metal-binding site 479435010530 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 479435010531 magnesium binding site [ion binding]; other site 479435010532 putative shikimate binding site; other site 479435010533 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 479435010534 Tetramer interface [polypeptide binding]; other site 479435010535 Active site [active] 479435010536 FMN-binding site [chemical binding]; other site 479435010537 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435010538 FAD binding domain; Region: FAD_binding_4; pfam01565 479435010539 Berberine and berberine like; Region: BBE; pfam08031 479435010540 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435010541 FAD binding domain; Region: FAD_binding_4; pfam01565 479435010542 Berberine and berberine like; Region: BBE; pfam08031 479435010543 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 479435010544 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479435010545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010546 NAD(P) binding pocket [chemical binding]; other site 479435010547 YceG-like family; Region: YceG; pfam02618 479435010548 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 479435010549 dimerization interface [polypeptide binding]; other site 479435010550 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 479435010551 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 479435010552 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 479435010553 motif 1; other site 479435010554 active site 479435010555 motif 2; other site 479435010556 motif 3; other site 479435010557 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 479435010558 recombination factor protein RarA; Reviewed; Region: PRK13342 479435010559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435010560 Walker A motif; other site 479435010561 ATP binding site [chemical binding]; other site 479435010562 Walker B motif; other site 479435010563 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 479435010564 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435010565 DNA binding residues [nucleotide binding] 479435010566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435010568 putative substrate translocation pore; other site 479435010569 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 479435010570 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 479435010571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435010572 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 479435010573 active site 479435010574 Predicted transcriptional regulators [Transcription]; Region: COG1725 479435010575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435010576 DNA-binding site [nucleotide binding]; DNA binding site 479435010577 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435010578 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435010579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435010581 S-adenosylmethionine binding site [chemical binding]; other site 479435010582 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435010583 catalytic residue [active] 479435010584 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 479435010585 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 479435010586 dimer interface [polypeptide binding]; other site 479435010587 anticodon binding site; other site 479435010588 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 479435010589 homodimer interface [polypeptide binding]; other site 479435010590 motif 1; other site 479435010591 active site 479435010592 motif 2; other site 479435010593 GAD domain; Region: GAD; pfam02938 479435010594 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435010595 active site 479435010596 motif 3; other site 479435010597 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 479435010598 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 479435010599 dimer interface [polypeptide binding]; other site 479435010600 motif 1; other site 479435010601 active site 479435010602 motif 2; other site 479435010603 motif 3; other site 479435010604 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 479435010605 anticodon binding site; other site 479435010606 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435010607 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479435010608 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479435010609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435010610 Coenzyme A binding pocket [chemical binding]; other site 479435010611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435010612 Phosphotransferase enzyme family; Region: APH; pfam01636 479435010613 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 479435010614 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435010615 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 479435010616 synthetase active site [active] 479435010617 NTP binding site [chemical binding]; other site 479435010618 metal binding site [ion binding]; metal-binding site 479435010619 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 479435010620 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 479435010621 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435010622 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 479435010623 Protein export membrane protein; Region: SecD_SecF; cl14618 479435010624 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 479435010625 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 479435010626 Protein export membrane protein; Region: SecD_SecF; cl14618 479435010627 Preprotein translocase subunit; Region: YajC; cl00806 479435010628 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 479435010629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435010630 Walker A motif; other site 479435010631 ATP binding site [chemical binding]; other site 479435010632 Walker B motif; other site 479435010633 arginine finger; other site 479435010634 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 479435010635 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 479435010636 RuvA N terminal domain; Region: RuvA_N; pfam01330 479435010637 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 479435010638 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 479435010639 active site 479435010640 putative DNA-binding cleft [nucleotide binding]; other site 479435010641 dimer interface [polypeptide binding]; other site 479435010642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435010643 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 479435010644 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435010645 CoenzymeA binding site [chemical binding]; other site 479435010646 subunit interaction site [polypeptide binding]; other site 479435010647 PHB binding site; other site 479435010648 Domain of unknown function DUF28; Region: DUF28; cl00361 479435010649 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 479435010650 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 479435010651 predicted active site [active] 479435010652 catalytic triad [active] 479435010653 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 479435010654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435010655 Helicase associated domain (HA2); Region: HA2; cl04503 479435010656 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 479435010657 YCII-related domain; Region: YCII; cl00999 479435010658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010659 DNA binding residues [nucleotide binding] 479435010660 dimerization interface [polypeptide binding]; other site 479435010661 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435010662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010664 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435010665 FAD binding domain; Region: FAD_binding_4; pfam01565 479435010666 Berberine and berberine like; Region: BBE; pfam08031 479435010667 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435010668 DNA binding residues [nucleotide binding] 479435010669 dimer interface [polypeptide binding]; other site 479435010670 TM1410 hypothetical-related protein; Region: DUF297; cl00997 479435010671 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 479435010672 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 479435010673 active site 479435010674 multimer interface [polypeptide binding]; other site 479435010675 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435010676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435010677 DNA-binding site [nucleotide binding]; DNA binding site 479435010678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435010679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435010680 homodimer interface [polypeptide binding]; other site 479435010681 catalytic residue [active] 479435010682 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 479435010683 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 479435010684 active site 479435010685 DNA binding site [nucleotide binding] 479435010686 catalytic site [active] 479435010687 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435010688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435010690 DNA binding residues [nucleotide binding] 479435010691 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435010692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435010693 dimer interface [polypeptide binding]; other site 479435010694 phosphorylation site [posttranslational modification] 479435010695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435010696 ATP binding site [chemical binding]; other site 479435010697 Mg2+ binding site [ion binding]; other site 479435010698 G-X-G motif; other site 479435010699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435010700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010701 active site 479435010702 phosphorylation site [posttranslational modification] 479435010703 intermolecular recognition site; other site 479435010704 dimerization interface [polypeptide binding]; other site 479435010705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435010706 DNA binding site [nucleotide binding] 479435010707 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 479435010708 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479435010709 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435010710 tetramer interface [polypeptide binding]; other site 479435010711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435010712 catalytic residue [active] 479435010713 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 479435010714 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 479435010715 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435010716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435010717 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435010718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435010719 active site 479435010720 ATP binding site [chemical binding]; other site 479435010721 substrate binding site [chemical binding]; other site 479435010722 activation loop (A-loop); other site 479435010723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010724 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435010725 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435010726 Transport protein; Region: actII; TIGR00833 479435010727 Transport protein; Region: actII; TIGR00833 479435010728 Anti-sigma-K factor rskA; Region: RskA; cl02208 479435010729 RNA polymerase sigma factor; Provisional; Region: PRK12519 479435010730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435010732 DNA binding residues [nucleotide binding] 479435010733 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 479435010734 active site 479435010735 putative catalytic site [active] 479435010736 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 479435010737 putative hydrophobic ligand binding site [chemical binding]; other site 479435010738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010739 TIGR01777 family protein; Region: yfcH 479435010740 NAD(P) binding site [chemical binding]; other site 479435010741 active site 479435010742 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 479435010743 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435010744 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 479435010745 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 479435010746 active site 479435010747 Acetokinase family; Region: Acetate_kinase; cl01029 479435010748 phosphate acetyltransferase; Reviewed; Region: PRK05632 479435010749 DRTGG domain; Region: DRTGG; cl12147 479435010750 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 479435010751 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 479435010752 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 479435010753 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435010754 anti sigma factor interaction site; other site 479435010755 regulatory phosphorylation site [posttranslational modification]; other site 479435010756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435010757 dimer interface [polypeptide binding]; other site 479435010758 phosphorylation site [posttranslational modification] 479435010759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435010760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435010761 ATP binding site [chemical binding]; other site 479435010762 Mg2+ binding site [ion binding]; other site 479435010763 G-X-G motif; other site 479435010764 Response regulator receiver domain; Region: Response_reg; pfam00072 479435010765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010766 active site 479435010767 phosphorylation site [posttranslational modification] 479435010768 intermolecular recognition site; other site 479435010769 dimerization interface [polypeptide binding]; other site 479435010770 PAS domain S-box; Region: sensory_box; TIGR00229 479435010771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435010772 putative active site [active] 479435010773 heme pocket [chemical binding]; other site 479435010774 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435010775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435010776 dimer interface [polypeptide binding]; other site 479435010777 putative PBP binding regions; other site 479435010778 ABC-ATPase subunit interface; other site 479435010779 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435010780 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435010781 Walker A/P-loop; other site 479435010782 ATP binding site [chemical binding]; other site 479435010783 Q-loop/lid; other site 479435010784 ABC transporter signature motif; other site 479435010785 Walker B; other site 479435010786 D-loop; other site 479435010787 H-loop/switch region; other site 479435010788 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435010789 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435010790 intersubunit interface [polypeptide binding]; other site 479435010791 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435010792 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 479435010793 Predicted ATPase [General function prediction only]; Region: COG3899 479435010794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010795 DNA binding residues [nucleotide binding] 479435010796 dimerization interface [polypeptide binding]; other site 479435010797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010798 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 479435010799 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435010800 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 479435010801 putative NAD(P) binding site [chemical binding]; other site 479435010802 Arginase family; Region: Arginase; cl00306 479435010803 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 479435010804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435010806 DNA binding residues [nucleotide binding] 479435010807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010808 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 479435010809 NmrA-like family; Region: NmrA; pfam05368 479435010810 NADP binding site [chemical binding]; other site 479435010811 active site 479435010812 regulatory binding site [polypeptide binding]; other site 479435010813 FAD binding domain; Region: FAD_binding_4; pfam01565 479435010814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435010815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010816 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435010817 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435010818 putative NAD(P) binding site [chemical binding]; other site 479435010819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010821 active site 479435010822 phosphorylation site [posttranslational modification] 479435010823 intermolecular recognition site; other site 479435010824 dimerization interface [polypeptide binding]; other site 479435010825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010826 DNA binding residues [nucleotide binding] 479435010827 dimerization interface [polypeptide binding]; other site 479435010828 Histidine kinase; Region: HisKA_3; pfam07730 479435010829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435010830 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435010831 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435010832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 479435010833 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435010834 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435010835 Walker A/P-loop; other site 479435010836 ATP binding site [chemical binding]; other site 479435010837 Q-loop/lid; other site 479435010838 ABC transporter signature motif; other site 479435010839 Walker B; other site 479435010840 D-loop; other site 479435010841 H-loop/switch region; other site 479435010842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435010843 ABC-ATPase subunit interface; other site 479435010844 dimer interface [polypeptide binding]; other site 479435010845 putative PBP binding regions; other site 479435010846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435010847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435010848 S-adenosylmethionine binding site [chemical binding]; other site 479435010849 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435010850 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 479435010851 intersubunit interface [polypeptide binding]; other site 479435010852 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435010853 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435010854 Walker A/P-loop; other site 479435010855 ATP binding site [chemical binding]; other site 479435010856 Q-loop/lid; other site 479435010857 ABC transporter signature motif; other site 479435010858 Walker B; other site 479435010859 D-loop; other site 479435010860 H-loop/switch region; other site 479435010861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435010863 active site 479435010864 phosphorylation site [posttranslational modification] 479435010865 intermolecular recognition site; other site 479435010866 dimerization interface [polypeptide binding]; other site 479435010867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435010868 DNA binding residues [nucleotide binding] 479435010869 dimerization interface [polypeptide binding]; other site 479435010870 Histidine kinase; Region: HisKA_3; pfam07730 479435010871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435010872 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435010873 conserved cys residue [active] 479435010874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435010876 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 479435010877 active site 479435010878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435010880 putative substrate translocation pore; other site 479435010881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010882 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010883 YCII-related domain; Region: YCII; cl00999 479435010884 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435010885 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435010886 domain; Region: Glyco_hydro_2; pfam00703 479435010887 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435010888 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435010889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435010890 DNA-binding site [nucleotide binding]; DNA binding site 479435010891 FCD domain; Region: FCD; cl11656 479435010892 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 479435010893 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435010894 active site pocket [active] 479435010895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435010896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010897 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435010898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010899 dimer interface [polypeptide binding]; other site 479435010900 conserved gate region; other site 479435010901 putative PBP binding loops; other site 479435010902 ABC-ATPase subunit interface; other site 479435010903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435010904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010905 dimer interface [polypeptide binding]; other site 479435010906 conserved gate region; other site 479435010907 putative PBP binding loops; other site 479435010908 ABC-ATPase subunit interface; other site 479435010909 classical (c) SDRs; Region: SDR_c; cd05233 479435010910 NAD(P) binding site [chemical binding]; other site 479435010911 active site 479435010912 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435010913 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435010914 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435010915 inhibitor site; inhibition site 479435010916 active site 479435010917 dimer interface [polypeptide binding]; other site 479435010918 catalytic residue [active] 479435010919 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435010920 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435010921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010922 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435010923 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 479435010924 classical (c) SDRs; Region: SDR_c; cd05233 479435010925 NAD(P) binding site [chemical binding]; other site 479435010926 active site 479435010927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010930 DNA binding site [nucleotide binding] 479435010931 domain linker motif; other site 479435010932 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435010933 ligand binding site [chemical binding]; other site 479435010934 dimerization interface [polypeptide binding]; other site 479435010935 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435010936 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479435010937 active site 479435010938 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435010939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435010942 dimer interface [polypeptide binding]; other site 479435010943 conserved gate region; other site 479435010944 putative PBP binding loops; other site 479435010945 ABC-ATPase subunit interface; other site 479435010946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435010947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435010948 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479435010949 active site 479435010950 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435010951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435010952 LysE type translocator; Region: LysE; cl00565 479435010953 Dehydratase family; Region: ILVD_EDD; cl00340 479435010954 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 479435010955 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435010956 classical (c) SDRs; Region: SDR_c; cd05233 479435010957 NAD(P) binding site [chemical binding]; other site 479435010958 active site 479435010959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010960 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435010961 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435010962 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 479435010963 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435010964 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435010965 Beta-lactamase; Region: Beta-lactamase; cl01009 479435010966 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435010967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435010968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010969 active site 479435010970 metal binding site [ion binding]; metal-binding site 479435010971 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435010972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435010973 Uncharacterized conserved protein [Function unknown]; Region: COG4278 479435010974 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435010975 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435010976 active site 479435010977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435010978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435010979 active site 479435010980 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435010983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435010984 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435010985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435010986 Walker A/P-loop; other site 479435010987 ATP binding site [chemical binding]; other site 479435010988 Q-loop/lid; other site 479435010989 ABC transporter signature motif; other site 479435010990 Walker B; other site 479435010991 D-loop; other site 479435010992 H-loop/switch region; other site 479435010993 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435010994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010995 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435010996 CoA-transferase family III; Region: CoA_transf_3; cl00778 479435010997 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 479435010998 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435010999 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435011000 substrate binding site [chemical binding]; other site 479435011001 ATP binding site [chemical binding]; other site 479435011002 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435011003 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435011004 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011008 dimer interface [polypeptide binding]; other site 479435011009 conserved gate region; other site 479435011010 putative PBP binding loops; other site 479435011011 ABC-ATPase subunit interface; other site 479435011012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011013 dimer interface [polypeptide binding]; other site 479435011014 conserved gate region; other site 479435011015 putative PBP binding loops; other site 479435011016 ABC-ATPase subunit interface; other site 479435011017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435011018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011019 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435011020 ligand binding site [chemical binding]; other site 479435011021 dimerization interface [polypeptide binding]; other site 479435011022 Ion channel; Region: Ion_trans_2; cl11596 479435011023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011024 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435011025 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435011026 active site 479435011027 catalytic site [active] 479435011028 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 479435011029 putative active site [active] 479435011030 catalytic site [active] 479435011031 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435011032 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 479435011033 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 479435011034 phosphoglucomutase; Validated; Region: PRK07564 479435011035 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 479435011036 active site 479435011037 substrate binding site [chemical binding]; other site 479435011038 metal binding site [ion binding]; metal-binding site 479435011039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435011040 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435011041 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435011042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011045 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435011046 NAD(P) binding site [chemical binding]; other site 479435011047 active site 479435011048 YceI-like domain; Region: YceI; cl01001 479435011049 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 479435011050 Protein of unknown function (DUF429); Region: DUF429; cl12046 479435011051 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435011052 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 479435011053 active site 479435011054 substrate binding site [chemical binding]; other site 479435011055 catalytic site [active] 479435011056 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 479435011057 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 479435011058 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 479435011059 active site 479435011060 metal binding site [ion binding]; metal-binding site 479435011061 homotetramer interface [polypeptide binding]; other site 479435011062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435011063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011064 NAD(P) binding site [chemical binding]; other site 479435011065 active site 479435011066 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435011067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011068 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 479435011069 putative dimer interface [polypeptide binding]; other site 479435011070 ligand binding site [chemical binding]; other site 479435011071 Zn binding site [ion binding]; other site 479435011072 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 479435011073 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435011074 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435011075 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435011076 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435011077 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 479435011078 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435011079 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435011080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011081 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435011082 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435011083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011085 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435011086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011087 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435011088 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435011089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011090 S-adenosylmethionine binding site [chemical binding]; other site 479435011091 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435011092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435011093 DNA-binding site [nucleotide binding]; DNA binding site 479435011094 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479435011095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011096 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011098 dimer interface [polypeptide binding]; other site 479435011099 conserved gate region; other site 479435011100 putative PBP binding loops; other site 479435011101 ABC-ATPase subunit interface; other site 479435011102 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435011103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011104 dimer interface [polypeptide binding]; other site 479435011105 putative PBP binding loops; other site 479435011106 ABC-ATPase subunit interface; other site 479435011107 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011109 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435011110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011111 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 479435011112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 479435011113 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435011114 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 479435011115 Protein of unknown function (DUF805); Region: DUF805; cl01224 479435011116 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 479435011117 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435011118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011119 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435011120 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435011121 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435011122 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479435011123 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 479435011124 putative NAD(P) binding site [chemical binding]; other site 479435011125 active site 479435011126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011127 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435011128 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435011129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435011130 active site 479435011131 catalytic tetrad [active] 479435011132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435011133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011134 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 479435011135 putative dimerization interface [polypeptide binding]; other site 479435011136 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435011137 His/Ser-rich radical SAM pair-associated protein; Region: His_Ser_Rich; TIGR03979 479435011138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435011139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011140 Domain of unknown function (DUF955); Region: DUF955; cl01076 479435011141 amidase; Provisional; Region: PRK07042 479435011142 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435011143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011144 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 479435011145 classical (c) SDRs; Region: SDR_c; cd05233 479435011146 NAD(P) binding site [chemical binding]; other site 479435011147 active site 479435011148 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435011149 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435011150 NAD(P) binding site [chemical binding]; other site 479435011151 catalytic residues [active] 479435011152 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435011153 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435011154 Walker A/P-loop; other site 479435011155 ATP binding site [chemical binding]; other site 479435011156 Q-loop/lid; other site 479435011157 ABC transporter signature motif; other site 479435011158 Walker B; other site 479435011159 D-loop; other site 479435011160 H-loop/switch region; other site 479435011161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435011162 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435011163 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435011164 Walker A/P-loop; other site 479435011165 ATP binding site [chemical binding]; other site 479435011166 Q-loop/lid; other site 479435011167 ABC transporter signature motif; other site 479435011168 Walker B; other site 479435011169 D-loop; other site 479435011170 H-loop/switch region; other site 479435011171 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435011172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435011173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435011174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011175 dimer interface [polypeptide binding]; other site 479435011176 conserved gate region; other site 479435011177 putative PBP binding loops; other site 479435011178 ABC-ATPase subunit interface; other site 479435011179 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 479435011180 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435011181 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15255 479435011182 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479435011183 putative metal binding site [ion binding]; other site 479435011184 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435011185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011186 putative substrate translocation pore; other site 479435011187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435011188 metal binding site [ion binding]; metal-binding site 479435011189 active site 479435011190 I-site; other site 479435011191 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 479435011192 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435011193 putative NAD(P) binding site [chemical binding]; other site 479435011194 SNF2 Helicase protein; Region: DUF3670; pfam12419 479435011195 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 479435011196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435011197 ATP binding site [chemical binding]; other site 479435011198 putative Mg++ binding site [ion binding]; other site 479435011199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435011200 nucleotide binding region [chemical binding]; other site 479435011201 ATP-binding site [chemical binding]; other site 479435011202 Uncharacterized conserved protein [Function unknown]; Region: COG4279 479435011203 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435011204 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435011205 active site 479435011206 catalytic triad [active] 479435011207 oxyanion hole [active] 479435011208 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435011209 putative metal binding site [ion binding]; other site 479435011210 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435011211 putative metal binding site [ion binding]; other site 479435011212 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435011213 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435011214 putative metal binding site [ion binding]; other site 479435011215 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435011216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011217 dimer interface [polypeptide binding]; other site 479435011218 conserved gate region; other site 479435011219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435011220 ABC-ATPase subunit interface; other site 479435011221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435011222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011224 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435011225 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435011226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435011227 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435011228 DNA binding site [nucleotide binding] 479435011229 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435011230 ligand binding site [chemical binding]; other site 479435011231 dimerization interface [polypeptide binding]; other site 479435011232 hypothetical protein; Provisional; Region: PRK04140 479435011233 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435011234 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435011235 active site 479435011236 catalytic tetrad [active] 479435011237 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435011238 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435011239 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435011240 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435011241 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 479435011242 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 479435011243 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 479435011244 active site 479435011245 dimer interface [polypeptide binding]; other site 479435011246 effector binding site; other site 479435011247 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 479435011248 TSCPD domain; Region: TSCPD; cl14834 479435011249 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 479435011250 ATP cone domain; Region: ATP-cone; pfam03477 479435011251 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435011252 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435011253 active site 479435011254 catalytic site [active] 479435011255 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479435011256 active site 479435011257 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 479435011258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011259 LexA repressor; Validated; Region: PRK00215 479435011260 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 479435011261 Catalytic site [active] 479435011262 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 479435011263 catalytic residues [active] 479435011264 dimer interface [polypeptide binding]; other site 479435011265 thiamine pyrophosphate protein; Provisional; Region: PRK08273 479435011266 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 479435011267 PYR/PP interface [polypeptide binding]; other site 479435011268 tetramer interface [polypeptide binding]; other site 479435011269 dimer interface [polypeptide binding]; other site 479435011270 TPP binding site [chemical binding]; other site 479435011271 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435011272 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 479435011273 TPP-binding site [chemical binding]; other site 479435011274 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 479435011275 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 479435011276 active site 479435011277 DNA binding site [nucleotide binding] 479435011278 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 479435011279 DNA binding site [nucleotide binding] 479435011280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435011282 putative Mg++ binding site [ion binding]; other site 479435011283 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 479435011284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011285 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 479435011286 Protein export membrane protein; Region: SecD_SecF; cl14618 479435011287 Protein export membrane protein; Region: SecD_SecF; cl14618 479435011288 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435011289 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 479435011290 calcium binding site 2 [ion binding]; other site 479435011291 active site 479435011292 catalytic triad [active] 479435011293 calcium binding site 1 [ion binding]; other site 479435011294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435011296 active site 479435011297 phosphorylation site [posttranslational modification] 479435011298 intermolecular recognition site; other site 479435011299 dimerization interface [polypeptide binding]; other site 479435011300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435011301 DNA binding residues [nucleotide binding] 479435011302 dimerization interface [polypeptide binding]; other site 479435011303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435011304 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435011305 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 479435011306 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 479435011307 G1 box; other site 479435011308 GTP/Mg2+ binding site [chemical binding]; other site 479435011309 Switch I region; other site 479435011310 G2 box; other site 479435011311 G3 box; other site 479435011312 Switch II region; other site 479435011313 G4 box; other site 479435011314 G5 box; other site 479435011315 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 479435011316 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 479435011317 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 479435011318 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479435011319 Zn binding site [ion binding]; other site 479435011320 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435011321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011323 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479435011324 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435011325 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435011326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011328 IPP transferase; Region: IPPT; cl00403 479435011329 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 479435011330 nudix motif; other site 479435011331 Phosphotransferase enzyme family; Region: APH; pfam01636 479435011332 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435011333 active site 479435011334 substrate binding site [chemical binding]; other site 479435011335 ATP binding site [chemical binding]; other site 479435011336 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 479435011337 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479435011338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435011339 FeS/SAM binding site; other site 479435011340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435011341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435011342 active site 479435011343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435011344 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435011345 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 479435011346 Walker A/P-loop; other site 479435011347 ATP binding site [chemical binding]; other site 479435011348 Q-loop/lid; other site 479435011349 ABC transporter signature motif; other site 479435011350 Walker B; other site 479435011351 D-loop; other site 479435011352 H-loop/switch region; other site 479435011353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435011354 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479435011355 substrate binding pocket [chemical binding]; other site 479435011356 membrane-bound complex binding site; other site 479435011357 hinge residues; other site 479435011358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011359 dimer interface [polypeptide binding]; other site 479435011360 conserved gate region; other site 479435011361 putative PBP binding loops; other site 479435011362 ABC-ATPase subunit interface; other site 479435011363 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435011364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011365 dimer interface [polypeptide binding]; other site 479435011366 conserved gate region; other site 479435011367 putative PBP binding loops; other site 479435011368 ABC-ATPase subunit interface; other site 479435011369 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 479435011370 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 479435011371 putative active site [active] 479435011372 putative substrate binding site [chemical binding]; other site 479435011373 ATP binding site [chemical binding]; other site 479435011374 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 479435011375 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 479435011376 inhibitor-cofactor binding pocket; inhibition site 479435011377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435011378 catalytic residue [active] 479435011379 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 479435011380 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 479435011381 dimer interface [polypeptide binding]; other site 479435011382 pyridoxal binding site [chemical binding]; other site 479435011383 ATP binding site [chemical binding]; other site 479435011384 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 479435011385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435011386 FeS/SAM binding site; other site 479435011387 Rdx family; Region: Rdx; cl01407 479435011388 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435011389 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435011390 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435011391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435011392 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 479435011393 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 479435011394 hinge region; other site 479435011395 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 479435011396 putative nucleotide binding site [chemical binding]; other site 479435011397 uridine monophosphate binding site [chemical binding]; other site 479435011398 homohexameric interface [polypeptide binding]; other site 479435011399 elongation factor Ts; Provisional; Region: tsf; PRK09377 479435011400 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 479435011401 Elongation factor TS; Region: EF_TS; pfam00889 479435011402 Elongation factor TS; Region: EF_TS; pfam00889 479435011403 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 479435011404 rRNA interaction site [nucleotide binding]; other site 479435011405 S8 interaction site; other site 479435011406 putative laminin-1 binding site; other site 479435011407 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435011408 Predicted transcriptional regulator [Transcription]; Region: COG1959 479435011409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011410 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479435011411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435011412 DNA binding site [nucleotide binding] 479435011413 Int/Topo IB signature motif; other site 479435011414 active site 479435011415 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435011416 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 479435011417 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 479435011418 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479435011419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011420 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 479435011421 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 479435011422 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 479435011423 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 479435011424 RNA/DNA hybrid binding site [nucleotide binding]; other site 479435011425 active site 479435011426 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 479435011427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479435011428 Catalytic site [active] 479435011429 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479435011430 Catalytic site [active] 479435011431 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 479435011432 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 479435011433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435011434 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 479435011435 RimM N-terminal domain; Region: RimM; pfam01782 479435011436 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 479435011437 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 479435011438 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 479435011439 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 479435011440 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 479435011441 NAD binding site [chemical binding]; other site 479435011442 sugar binding site [chemical binding]; other site 479435011443 divalent metal binding site [ion binding]; other site 479435011444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435011445 dimer interface [polypeptide binding]; other site 479435011446 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435011447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011448 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435011449 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435011450 substrate binding site [chemical binding]; other site 479435011451 ATP binding site [chemical binding]; other site 479435011452 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 479435011453 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435011454 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435011455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435011457 active site 479435011458 phosphorylation site [posttranslational modification] 479435011459 intermolecular recognition site; other site 479435011460 dimerization interface [polypeptide binding]; other site 479435011461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435011462 DNA binding residues [nucleotide binding] 479435011463 dimerization interface [polypeptide binding]; other site 479435011464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435011465 Histidine kinase; Region: HisKA_3; pfam07730 479435011466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435011467 ATP binding site [chemical binding]; other site 479435011468 Mg2+ binding site [ion binding]; other site 479435011469 G-X-G motif; other site 479435011470 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435011471 amidase catalytic site [active] 479435011472 Zn binding residues [ion binding]; other site 479435011473 substrate binding site [chemical binding]; other site 479435011474 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435011475 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435011476 active site 479435011477 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435011478 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 479435011479 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435011480 catalytic residue [active] 479435011481 signal recognition particle protein; Provisional; Region: PRK10867 479435011482 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 479435011483 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 479435011484 P loop; other site 479435011485 GTP binding site [chemical binding]; other site 479435011486 Signal peptide binding domain; Region: SRP_SPB; pfam02978 479435011487 Arginase family; Region: Arginase; cl00306 479435011488 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 479435011489 PII uridylyl-transferase; Provisional; Region: PRK03381 479435011490 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435011491 metal binding triad; other site 479435011492 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435011493 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 479435011494 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 479435011495 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 479435011496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011497 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435011498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011499 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 479435011500 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479435011501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435011502 non-specific DNA binding site [nucleotide binding]; other site 479435011503 salt bridge; other site 479435011504 sequence-specific DNA binding site [nucleotide binding]; other site 479435011505 Cupin domain; Region: Cupin_2; cl09118 479435011506 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 479435011507 active site/substrate binding site [active] 479435011508 tetramer interface [polypeptide binding]; other site 479435011509 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435011510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011512 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 479435011513 apolar tunnel; other site 479435011514 heme binding site [chemical binding]; other site 479435011515 dimerization interface [polypeptide binding]; other site 479435011516 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479435011517 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 479435011518 heme-binding site [chemical binding]; other site 479435011519 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 479435011520 FAD binding pocket [chemical binding]; other site 479435011521 FAD binding motif [chemical binding]; other site 479435011522 phosphate binding motif [ion binding]; other site 479435011523 beta-alpha-beta structure motif; other site 479435011524 NAD binding pocket [chemical binding]; other site 479435011525 DivIVA protein; Region: DivIVA; pfam05103 479435011526 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 479435011527 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 479435011528 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435011529 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 479435011530 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 479435011531 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435011532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011533 Walker A/P-loop; other site 479435011534 ATP binding site [chemical binding]; other site 479435011535 Q-loop/lid; other site 479435011536 ABC transporter signature motif; other site 479435011537 Walker B; other site 479435011538 D-loop; other site 479435011539 H-loop/switch region; other site 479435011540 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 479435011541 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435011542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011543 Walker A/P-loop; other site 479435011544 ATP binding site [chemical binding]; other site 479435011545 Q-loop/lid; other site 479435011546 ABC transporter signature motif; other site 479435011547 Walker B; other site 479435011548 D-loop; other site 479435011549 H-loop/switch region; other site 479435011550 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 479435011551 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 479435011552 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 479435011553 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 479435011554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011555 Peptidase family M48; Region: Peptidase_M48; cl12018 479435011556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435011557 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 479435011558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435011559 catalytic residue [active] 479435011560 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 479435011561 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 479435011562 Walker A/P-loop; other site 479435011563 ATP binding site [chemical binding]; other site 479435011564 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 479435011565 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 479435011566 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 479435011567 ABC transporter signature motif; other site 479435011568 Walker B; other site 479435011569 D-loop; other site 479435011570 H-loop/switch region; other site 479435011571 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 479435011572 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 479435011573 DNA binding site [nucleotide binding] 479435011574 catalytic residue [active] 479435011575 H2TH interface [polypeptide binding]; other site 479435011576 putative catalytic residues [active] 479435011577 turnover-facilitating residue; other site 479435011578 intercalation triad [nucleotide binding]; other site 479435011579 8OG recognition residue [nucleotide binding]; other site 479435011580 putative reading head residues; other site 479435011581 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435011582 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435011583 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 479435011584 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 479435011585 dimerization interface [polypeptide binding]; other site 479435011586 active site 479435011587 metal binding site [ion binding]; metal-binding site 479435011588 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 479435011589 dsRNA binding site [nucleotide binding]; other site 479435011590 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 479435011591 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 479435011592 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 479435011593 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 479435011594 active site 479435011595 (T/H)XGH motif; other site 479435011596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011597 S-adenosylmethionine binding site [chemical binding]; other site 479435011598 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 479435011599 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 479435011600 generic binding surface II; other site 479435011601 ssDNA binding site; other site 479435011602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435011603 ATP binding site [chemical binding]; other site 479435011604 putative Mg++ binding site [ion binding]; other site 479435011605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435011606 nucleotide binding region [chemical binding]; other site 479435011607 ATP-binding site [chemical binding]; other site 479435011608 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 479435011609 DAK2 domain; Region: Dak2; cl03685 479435011610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435011611 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 479435011612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435011613 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435011614 Predicted kinase [General function prediction only]; Region: COG0645 479435011615 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 479435011616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435011617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011618 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435011619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435011620 active site 479435011621 catalytic tetrad [active] 479435011622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011624 dimer interface [polypeptide binding]; other site 479435011625 conserved gate region; other site 479435011626 putative PBP binding loops; other site 479435011627 ABC-ATPase subunit interface; other site 479435011628 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011630 dimer interface [polypeptide binding]; other site 479435011631 conserved gate region; other site 479435011632 putative PBP binding loops; other site 479435011633 ABC-ATPase subunit interface; other site 479435011634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435011637 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479435011638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435011639 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435011640 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 479435011641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435011642 active site 479435011643 motif I; other site 479435011644 motif II; other site 479435011645 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435011646 DinB superfamily; Region: DinB_2; cl00986 479435011647 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 479435011648 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 479435011649 dimer interface [polypeptide binding]; other site 479435011650 substrate binding site [chemical binding]; other site 479435011651 ATP binding site [chemical binding]; other site 479435011652 thiamine monophosphate kinase; Provisional; Region: PRK05731 479435011653 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 479435011654 ATP binding site [chemical binding]; other site 479435011655 dimerization interface [polypeptide binding]; other site 479435011656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011657 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 479435011658 Histidine kinase; Region: HisKA_3; pfam07730 479435011659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435011660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435011662 active site 479435011663 phosphorylation site [posttranslational modification] 479435011664 intermolecular recognition site; other site 479435011665 dimerization interface [polypeptide binding]; other site 479435011666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435011667 DNA binding residues [nucleotide binding] 479435011668 dimerization interface [polypeptide binding]; other site 479435011669 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435011670 YCII-related domain; Region: YCII; cl00999 479435011671 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435011672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435011674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 479435011675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011676 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435011677 putative substrate translocation pore; other site 479435011678 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 479435011679 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435011680 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435011681 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 479435011682 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 479435011683 Cytochrome P450; Region: p450; cl12078 479435011684 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435011685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011686 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 479435011687 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435011688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435011689 catalytic residue [active] 479435011690 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435011691 active site 479435011692 ATP binding site [chemical binding]; other site 479435011693 substrate binding site [chemical binding]; other site 479435011694 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435011695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011696 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435011697 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435011698 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 479435011699 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435011700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011701 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435011702 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435011703 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435011704 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 479435011705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011706 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 479435011707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435011708 putative acyl-acceptor binding pocket; other site 479435011709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435011710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435011711 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 479435011712 IHF - DNA interface [nucleotide binding]; other site 479435011713 IHF dimer interface [polypeptide binding]; other site 479435011714 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435011715 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 479435011716 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 479435011717 substrate binding site [chemical binding]; other site 479435011718 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 479435011719 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 479435011720 substrate binding site [chemical binding]; other site 479435011721 ligand binding site [chemical binding]; other site 479435011722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435011723 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435011724 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435011725 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435011726 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 479435011727 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479435011728 HIGH motif; other site 479435011729 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479435011730 active site 479435011731 KMSKS motif; other site 479435011732 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 479435011733 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479435011734 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479435011735 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435011736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435011737 Coenzyme A binding pocket [chemical binding]; other site 479435011738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011739 S-adenosylmethionine binding site [chemical binding]; other site 479435011740 DinB superfamily; Region: DinB_2; cl00986 479435011741 Class I ribonucleotide reductase; Region: RNR_I; cd01679 479435011742 active site 479435011743 dimer interface [polypeptide binding]; other site 479435011744 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 479435011745 catalytic residues [active] 479435011746 effector binding site; other site 479435011747 R2 peptide binding site; other site 479435011748 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 479435011749 dimer interface [polypeptide binding]; other site 479435011750 putative radical transfer pathway; other site 479435011751 diiron center [ion binding]; other site 479435011752 tyrosyl radical; other site 479435011753 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435011754 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435011755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011757 dimer interface [polypeptide binding]; other site 479435011758 conserved gate region; other site 479435011759 ABC-ATPase subunit interface; other site 479435011760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435011761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435011764 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435011765 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 479435011766 putative NAD(P) binding site [chemical binding]; other site 479435011767 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435011768 alpha-glucosidase; Provisional; Region: PRK10137 479435011769 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 479435011770 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 479435011771 active site 479435011772 catalytic residues [active] 479435011773 metal binding site [ion binding]; metal-binding site 479435011774 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 479435011775 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 479435011776 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 479435011777 homodimer interface [polypeptide binding]; other site 479435011778 substrate-cofactor binding pocket; other site 479435011779 catalytic residue [active] 479435011780 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 479435011781 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 479435011782 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 479435011783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011784 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 479435011785 putative L-serine binding site [chemical binding]; other site 479435011786 ketol-acid reductoisomerase; Provisional; Region: PRK05479 479435011787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011788 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 479435011789 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 479435011790 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 479435011791 putative valine binding site [chemical binding]; other site 479435011792 dimer interface [polypeptide binding]; other site 479435011793 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 479435011794 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 479435011795 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435011796 PYR/PP interface [polypeptide binding]; other site 479435011797 dimer interface [polypeptide binding]; other site 479435011798 TPP binding site [chemical binding]; other site 479435011799 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435011800 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 479435011801 TPP-binding site [chemical binding]; other site 479435011802 dimer interface [polypeptide binding]; other site 479435011803 Dehydratase family; Region: ILVD_EDD; cl00340 479435011804 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 479435011805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 479435011806 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435011807 MoaE interaction surface [polypeptide binding]; other site 479435011808 MoeB interaction surface [polypeptide binding]; other site 479435011809 thiocarboxylated glycine; other site 479435011810 VPS10 domain; Region: VPS10; smart00602 479435011811 VPS10 domain; Region: VPS10; smart00602 479435011812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011813 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435011814 TIGR03086 family protein; Region: TIGR03086 479435011815 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435011816 FAD binding domain; Region: FAD_binding_4; pfam01565 479435011817 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 479435011818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011819 S-adenosylmethionine binding site [chemical binding]; other site 479435011820 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 479435011821 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 479435011822 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 479435011823 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 479435011824 GatB domain; Region: GatB_Yqey; cl11497 479435011825 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479435011826 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435011827 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 479435011828 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435011829 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 479435011830 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 479435011831 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 479435011832 nucleotide binding pocket [chemical binding]; other site 479435011833 K-X-D-G motif; other site 479435011834 catalytic site [active] 479435011835 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 479435011836 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 479435011837 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 479435011838 Dimer interface [polypeptide binding]; other site 479435011839 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 479435011840 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 479435011841 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 479435011842 Ligand Binding Site [chemical binding]; other site 479435011843 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435011844 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 479435011845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435011846 catalytic residue [active] 479435011847 Beta-lactamase; Region: Beta-lactamase; cl01009 479435011848 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435011849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435011850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011851 dimer interface [polypeptide binding]; other site 479435011852 conserved gate region; other site 479435011853 ABC-ATPase subunit interface; other site 479435011854 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 479435011855 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435011856 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435011857 Walker A/P-loop; other site 479435011858 ATP binding site [chemical binding]; other site 479435011859 Q-loop/lid; other site 479435011860 ABC transporter signature motif; other site 479435011861 Walker B; other site 479435011862 D-loop; other site 479435011863 H-loop/switch region; other site 479435011864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435011865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435011866 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435011867 Walker A/P-loop; other site 479435011868 ATP binding site [chemical binding]; other site 479435011869 Q-loop/lid; other site 479435011870 ABC transporter signature motif; other site 479435011871 Walker B; other site 479435011872 D-loop; other site 479435011873 H-loop/switch region; other site 479435011874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435011875 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479435011876 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435011877 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435011878 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435011879 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435011880 Beta-lactamase; Region: Beta-lactamase; cl01009 479435011881 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 479435011882 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 479435011883 metal binding site [ion binding]; metal-binding site 479435011884 dimer interface [polypeptide binding]; other site 479435011885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435011886 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 479435011887 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 479435011888 active site 479435011889 octamer interface [polypeptide binding]; other site 479435011890 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 479435011891 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 479435011892 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 479435011893 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 479435011894 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 479435011895 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 479435011896 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 479435011897 Ligand binding site [chemical binding]; other site 479435011898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011899 S-adenosylmethionine binding site [chemical binding]; other site 479435011900 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 479435011901 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 479435011902 trimer interface [polypeptide binding]; other site 479435011903 active site 479435011904 substrate binding site [chemical binding]; other site 479435011905 CoA binding site [chemical binding]; other site 479435011906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435011907 S-adenosylmethionine binding site [chemical binding]; other site 479435011908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435011909 enoyl-CoA hydratase; Provisional; Region: PRK05862 479435011910 substrate binding site [chemical binding]; other site 479435011911 oxyanion hole (OAH) forming residues; other site 479435011912 trimer interface [polypeptide binding]; other site 479435011913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011914 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435011915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011916 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 479435011917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011919 dimer interface [polypeptide binding]; other site 479435011920 conserved gate region; other site 479435011921 putative PBP binding loops; other site 479435011922 ABC-ATPase subunit interface; other site 479435011923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435011924 dimer interface [polypeptide binding]; other site 479435011925 conserved gate region; other site 479435011926 putative PBP binding loops; other site 479435011927 ABC-ATPase subunit interface; other site 479435011928 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435011930 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479435011931 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 479435011932 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435011933 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 479435011934 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 479435011935 DNA binding residues [nucleotide binding] 479435011936 drug binding residues [chemical binding]; other site 479435011937 dimer interface [polypeptide binding]; other site 479435011938 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 479435011939 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 479435011940 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 479435011941 putative homodimer interface [polypeptide binding]; other site 479435011942 putative active site pocket [active] 479435011943 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 479435011944 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 479435011945 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435011946 transcriptional regulator PhoB; Provisional; Region: PRK10161 479435011947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435011948 DNA binding site [nucleotide binding] 479435011949 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435011950 active site 479435011951 catalytic residues [active] 479435011952 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 479435011953 kelch-like protein; Provisional; Region: PHA03098 479435011954 Kelch motif; Region: Kelch_1; cl02701 479435011955 Kelch motif; Region: Kelch_1; cl02701 479435011956 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 479435011957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435011958 DNA binding site [nucleotide binding] 479435011959 Glyco_18 domain; Region: Glyco_18; smart00636 479435011960 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 479435011961 active site 479435011962 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 479435011963 ligand binding site [chemical binding]; other site 479435011964 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 479435011965 trehalose synthase; Region: treS_nterm; TIGR02456 479435011966 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435011967 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 479435011968 glycogen branching enzyme; Provisional; Region: PRK05402 479435011969 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 479435011970 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435011971 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 479435011972 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435011973 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 479435011974 nudix motif; other site 479435011975 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435011976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011977 YCII-related domain; Region: YCII; cl00999 479435011978 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435011979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011980 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 479435011981 Citrate synthase; Region: Citrate_synt; pfam00285 479435011982 oxalacetate binding site [chemical binding]; other site 479435011983 citrylCoA binding site [chemical binding]; other site 479435011984 coenzyme A binding site [chemical binding]; other site 479435011985 catalytic triad [active] 479435011986 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435011987 Citrate synthase; Region: Citrate_synt; pfam00285 479435011988 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 479435011989 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 479435011990 oxalacetate binding site [chemical binding]; other site 479435011991 citrylCoA binding site [chemical binding]; other site 479435011992 coenzyme A binding site [chemical binding]; other site 479435011993 catalytic triad [active] 479435011994 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435011995 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 479435011996 putative active site [active] 479435011997 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 479435011998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011999 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435012000 active site 479435012001 intersubunit interface [polypeptide binding]; other site 479435012002 catalytic residue [active] 479435012003 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435012004 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 479435012005 metal binding site [ion binding]; metal-binding site 479435012006 substrate binding pocket [chemical binding]; other site 479435012007 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012009 dimer interface [polypeptide binding]; other site 479435012010 conserved gate region; other site 479435012011 putative PBP binding loops; other site 479435012012 ABC-ATPase subunit interface; other site 479435012013 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435012014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012015 ABC-ATPase subunit interface; other site 479435012016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435012018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012019 NAD(P) binding site [chemical binding]; other site 479435012020 active site 479435012021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012022 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435012023 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435012024 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 479435012025 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435012026 sugar binding site [chemical binding]; other site 479435012027 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 479435012028 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 479435012029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012030 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435012031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012032 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 479435012033 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 479435012034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012035 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435012036 DinB superfamily; Region: DinB_2; cl00986 479435012037 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 479435012038 active site 479435012039 substrate binding site [chemical binding]; other site 479435012040 trimer interface [polypeptide binding]; other site 479435012041 CoA binding site [chemical binding]; other site 479435012042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435012043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435012045 dimerization interface [polypeptide binding]; other site 479435012046 Bacterial membrane flanked domain; Region: DUF304; cl01348 479435012047 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 479435012048 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 479435012049 Walker A; other site 479435012050 putative acyltransferase; Provisional; Region: PRK05790 479435012051 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435012052 dimer interface [polypeptide binding]; other site 479435012053 active site 479435012054 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 479435012055 dimer interface [polypeptide binding]; other site 479435012056 substrate binding site [chemical binding]; other site 479435012057 metal binding site [ion binding]; metal-binding site 479435012058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435012059 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435012060 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 479435012061 NAD(P) binding site [chemical binding]; other site 479435012062 Domain of unknown function DUF20; Region: UPF0118; cl00465 479435012063 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435012064 acyl-CoA esterase; Provisional; Region: PRK10673 479435012065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012066 M28, and M42; Region: Zinc_peptidase_like; cl14876 479435012067 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 479435012068 metal binding site [ion binding]; metal-binding site 479435012069 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479435012070 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 479435012071 putative di-iron ligands [ion binding]; other site 479435012072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435012073 Histidine kinase; Region: HisKA_3; pfam07730 479435012074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435012076 active site 479435012077 phosphorylation site [posttranslational modification] 479435012078 intermolecular recognition site; other site 479435012079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435012080 DNA binding residues [nucleotide binding] 479435012081 YCII-related domain; Region: YCII; cl00999 479435012082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435012083 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 479435012084 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435012085 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 479435012086 Walker A/P-loop; other site 479435012087 ATP binding site [chemical binding]; other site 479435012088 Q-loop/lid; other site 479435012089 ABC transporter signature motif; other site 479435012090 Walker B; other site 479435012091 D-loop; other site 479435012092 H-loop/switch region; other site 479435012093 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435012094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012095 dimer interface [polypeptide binding]; other site 479435012096 conserved gate region; other site 479435012097 putative PBP binding loops; other site 479435012098 ABC-ATPase subunit interface; other site 479435012099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435012100 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435012101 substrate binding pocket [chemical binding]; other site 479435012102 membrane-bound complex binding site; other site 479435012103 hinge residues; other site 479435012104 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 479435012105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435012106 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435012107 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 479435012108 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435012109 active site 479435012110 substrate binding site [chemical binding]; other site 479435012111 ATP binding site [chemical binding]; other site 479435012112 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 479435012113 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435012114 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435012115 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 479435012116 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435012117 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435012118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435012119 S-adenosylmethionine binding site [chemical binding]; other site 479435012120 Protein of unknown function DUF91; Region: DUF91; cl00709 479435012121 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 479435012122 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 479435012123 glutaminase active site [active] 479435012124 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435012125 dimer interface [polypeptide binding]; other site 479435012126 active site 479435012127 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 479435012128 dimer interface [polypeptide binding]; other site 479435012129 active site 479435012130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 479435012131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435012132 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435012133 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435012134 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435012135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435012136 DNA-binding site [nucleotide binding]; DNA binding site 479435012137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435012138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435012139 homodimer interface [polypeptide binding]; other site 479435012140 catalytic residue [active] 479435012141 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 479435012142 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435012143 tetramer interface [polypeptide binding]; other site 479435012144 active site 479435012145 Mg2+/Mn2+ binding site [ion binding]; other site 479435012146 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435012147 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435012148 NAD binding site [chemical binding]; other site 479435012149 catalytic Zn binding site [ion binding]; other site 479435012150 structural Zn binding site [ion binding]; other site 479435012151 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435012152 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435012153 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012154 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435012155 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 479435012156 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 479435012157 B12 binding site [chemical binding]; other site 479435012158 cobalt ligand [ion binding]; other site 479435012159 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435012160 anti sigma factor interaction site; other site 479435012161 regulatory phosphorylation site [posttranslational modification]; other site 479435012162 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435012163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435012165 DNA binding residues [nucleotide binding] 479435012166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435012167 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435012168 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435012169 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435012170 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435012171 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 479435012172 ski2-like helicase; Provisional; Region: PRK02362 479435012173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435012174 ATP binding site [chemical binding]; other site 479435012175 putative Mg++ binding site [ion binding]; other site 479435012176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435012177 nucleotide binding region [chemical binding]; other site 479435012178 ATP-binding site [chemical binding]; other site 479435012179 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 479435012180 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435012181 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 479435012182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435012183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012184 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 479435012185 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 479435012186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012187 active site 479435012188 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 479435012189 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 479435012190 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 479435012191 hinge; other site 479435012192 active site 479435012193 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 479435012194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435012195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435012196 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435012197 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 479435012198 tandem repeat interface [polypeptide binding]; other site 479435012199 oligomer interface [polypeptide binding]; other site 479435012200 active site residues [active] 479435012201 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 479435012202 oligomer interface [polypeptide binding]; other site 479435012203 tandem repeat interface [polypeptide binding]; other site 479435012204 active site residues [active] 479435012205 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 479435012206 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 479435012207 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 479435012208 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 479435012209 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 479435012210 alpha subunit interaction interface [polypeptide binding]; other site 479435012211 Walker A motif; other site 479435012212 ATP binding site [chemical binding]; other site 479435012213 Walker B motif; other site 479435012214 inhibitor binding site; inhibition site 479435012215 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479435012216 ATP synthase; Region: ATP-synt; cl00365 479435012217 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 479435012218 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 479435012219 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 479435012220 beta subunit interaction interface [polypeptide binding]; other site 479435012221 Walker A motif; other site 479435012222 ATP binding site [chemical binding]; other site 479435012223 Walker B motif; other site 479435012224 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479435012225 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 479435012226 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 479435012227 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 479435012228 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 479435012229 ATP synthase subunit C; Region: ATP-synt_C; cl00466 479435012230 ATP synthase A chain; Region: ATP-synt_A; cl00413 479435012231 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 479435012232 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 479435012233 Mg++ binding site [ion binding]; other site 479435012234 putative catalytic motif [active] 479435012235 substrate binding site [chemical binding]; other site 479435012236 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 479435012237 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 479435012238 active site 479435012239 purine riboside binding site [chemical binding]; other site 479435012240 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 479435012241 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 479435012242 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 479435012243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435012244 S-adenosylmethionine binding site [chemical binding]; other site 479435012245 peptide chain release factor 1; Validated; Region: prfA; PRK00591 479435012246 RF-1 domain; Region: RF-1; cl02875 479435012247 RF-1 domain; Region: RF-1; cl02875 479435012248 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 479435012249 transcription termination factor Rho; Provisional; Region: PRK12678 479435012250 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 479435012251 transcription termination factor Rho; Provisional; Region: PRK12608 479435012252 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 479435012253 RNA binding site [nucleotide binding]; other site 479435012254 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 479435012255 multimer interface [polypeptide binding]; other site 479435012256 Walker A motif; other site 479435012257 ATP binding site [chemical binding]; other site 479435012258 Walker B motif; other site 479435012259 homoserine kinase; Provisional; Region: PRK01212 479435012260 threonine synthase; Reviewed; Region: PRK06721 479435012261 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 479435012262 homodimer interface [polypeptide binding]; other site 479435012263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435012264 catalytic residue [active] 479435012265 homoserine dehydrogenase; Provisional; Region: PRK06349 479435012266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012267 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 479435012268 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435012269 diaminopimelate decarboxylase; Region: lysA; TIGR01048 479435012270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 479435012271 active site 479435012272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435012273 substrate binding site [chemical binding]; other site 479435012274 catalytic residues [active] 479435012275 dimer interface [polypeptide binding]; other site 479435012276 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 479435012277 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 479435012278 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 479435012279 active site 479435012280 HIGH motif; other site 479435012281 KMSK motif region; other site 479435012282 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 479435012283 tRNA binding surface [nucleotide binding]; other site 479435012284 anticodon binding site; other site 479435012285 PspC domain; Region: PspC; cl00864 479435012286 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 479435012287 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 479435012288 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 479435012289 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 479435012290 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435012291 DinB superfamily; Region: DinB_2; cl00986 479435012292 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435012293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012295 YCII-related domain; Region: YCII; cl00999 479435012296 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 479435012297 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479435012298 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479435012299 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 479435012300 Uncharacterized conserved protein [Function unknown]; Region: COG2128 479435012301 A new structural DNA glycosylase; Region: AlkD_like; cl11434 479435012302 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435012303 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 479435012304 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 479435012305 putative sugar binding site [chemical binding]; other site 479435012306 catalytic residues [active] 479435012307 precorrin-3B synthase; Region: CobG; TIGR02435 479435012308 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435012309 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 479435012310 Precorrin-8X methylmutase; Region: CbiC; pfam02570 479435012311 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435012312 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435012313 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435012314 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435012315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435012316 dimerization interface [polypeptide binding]; other site 479435012317 putative DNA binding site [nucleotide binding]; other site 479435012318 putative Zn2+ binding site [ion binding]; other site 479435012319 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 479435012320 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 479435012321 active site 479435012322 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 479435012323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435012324 ATP binding site [chemical binding]; other site 479435012325 putative Mg++ binding site [ion binding]; other site 479435012326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435012327 nucleotide binding region [chemical binding]; other site 479435012328 ATP-binding site [chemical binding]; other site 479435012329 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 479435012330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012331 diacylglycerol kinase; Reviewed; Region: PRK11914 479435012332 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435012333 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 479435012334 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 479435012335 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435012336 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435012337 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 479435012338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 479435012339 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 479435012340 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435012341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435012342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012343 dimer interface [polypeptide binding]; other site 479435012344 conserved gate region; other site 479435012345 putative PBP binding loops; other site 479435012346 ABC-ATPase subunit interface; other site 479435012347 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435012348 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435012349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012350 dimer interface [polypeptide binding]; other site 479435012351 conserved gate region; other site 479435012352 putative PBP binding loops; other site 479435012353 ABC-ATPase subunit interface; other site 479435012354 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435012355 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435012356 Walker A/P-loop; other site 479435012357 ATP binding site [chemical binding]; other site 479435012358 Q-loop/lid; other site 479435012359 ABC transporter signature motif; other site 479435012360 Walker B; other site 479435012361 D-loop; other site 479435012362 H-loop/switch region; other site 479435012363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012364 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435012365 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435012366 Walker A/P-loop; other site 479435012367 ATP binding site [chemical binding]; other site 479435012368 Q-loop/lid; other site 479435012369 ABC transporter signature motif; other site 479435012370 Walker B; other site 479435012371 D-loop; other site 479435012372 H-loop/switch region; other site 479435012373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012374 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 479435012375 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 479435012376 isoform II; Region: PAF-AH_p_II; pfam03403 479435012377 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 479435012378 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435012379 RNA binding surface [nucleotide binding]; other site 479435012380 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 479435012381 active site 479435012382 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 479435012383 ScpA/B protein; Region: ScpA_ScpB; cl00598 479435012384 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 479435012385 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435012386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435012387 P-loop; other site 479435012388 Magnesium ion binding site [ion binding]; other site 479435012389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435012390 Magnesium ion binding site [ion binding]; other site 479435012391 Beta-lactamase; Region: Beta-lactamase; cl01009 479435012392 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 479435012393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435012394 DNA binding site [nucleotide binding] 479435012395 Int/Topo IB signature motif; other site 479435012396 active site 479435012397 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 479435012398 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 479435012399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435012401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012402 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435012403 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479435012404 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 479435012405 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 479435012406 nucleotide binding site/active site [active] 479435012407 catalytic residue [active] 479435012408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435012409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435012410 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 479435012411 homodimer interface [polypeptide binding]; other site 479435012412 homotetramer interface [polypeptide binding]; other site 479435012413 active site pocket [active] 479435012414 cleavage site 479435012415 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435012416 active site 479435012417 catalytic residues [active] 479435012418 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479435012419 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435012420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012421 Beta/Gamma crystallin; Region: Crystall; cl02528 479435012422 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 479435012423 homopentamer interface [polypeptide binding]; other site 479435012424 active site 479435012425 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 479435012426 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 479435012427 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 479435012428 dimerization interface [polypeptide binding]; other site 479435012429 active site 479435012430 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 479435012431 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 479435012432 Lumazine binding domain; Region: Lum_binding; pfam00677 479435012433 Lumazine binding domain; Region: Lum_binding; pfam00677 479435012434 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 479435012435 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 479435012436 catalytic motif [active] 479435012437 Zn binding site [ion binding]; other site 479435012438 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435012439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012440 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435012441 Walker A/P-loop; other site 479435012442 ATP binding site [chemical binding]; other site 479435012443 Q-loop/lid; other site 479435012444 ABC transporter signature motif; other site 479435012445 Walker B; other site 479435012446 D-loop; other site 479435012447 H-loop/switch region; other site 479435012448 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435012449 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435012450 active site 479435012451 ATP binding site [chemical binding]; other site 479435012452 substrate binding site [chemical binding]; other site 479435012453 activation loop (A-loop); other site 479435012454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435012455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435012457 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435012458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435012459 substrate binding pocket [chemical binding]; other site 479435012460 membrane-bound complex binding site; other site 479435012461 hinge residues; other site 479435012462 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435012463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012464 dimer interface [polypeptide binding]; other site 479435012465 conserved gate region; other site 479435012466 putative PBP binding loops; other site 479435012467 ABC-ATPase subunit interface; other site 479435012468 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435012469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012470 Walker A/P-loop; other site 479435012471 ATP binding site [chemical binding]; other site 479435012472 Q-loop/lid; other site 479435012473 ABC transporter signature motif; other site 479435012474 Walker B; other site 479435012475 D-loop; other site 479435012476 H-loop/switch region; other site 479435012477 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435012478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435012479 UMP phosphatase; Provisional; Region: PRK10444 479435012480 active site 479435012481 motif I; other site 479435012482 motif II; other site 479435012483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435012484 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 479435012485 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 479435012486 substrate binding site [chemical binding]; other site 479435012487 hexamer interface [polypeptide binding]; other site 479435012488 metal binding site [ion binding]; metal-binding site 479435012489 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 479435012490 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 479435012491 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435012492 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435012493 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 479435012494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435012495 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435012496 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435012497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435012498 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435012499 Walker A/P-loop; other site 479435012500 ATP binding site [chemical binding]; other site 479435012501 Q-loop/lid; other site 479435012502 ABC transporter signature motif; other site 479435012503 Walker B; other site 479435012504 D-loop; other site 479435012505 H-loop/switch region; other site 479435012506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012507 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435012508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012510 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435012511 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435012512 DNA binding site [nucleotide binding] 479435012513 domain linker motif; other site 479435012514 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435012515 ligand binding site [chemical binding]; other site 479435012516 dimerization interface [polypeptide binding]; other site 479435012517 probable methyltransferase; Region: TIGR03438 479435012518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012519 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 479435012520 TIGR03442 family protein; Region: TIGR03442 479435012521 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 479435012522 putative active site [active] 479435012523 putative dimer interface [polypeptide binding]; other site 479435012524 TIGR03440 family protein; Region: unchr_TIGR03440 479435012525 DinB superfamily; Region: DinB_2; cl00986 479435012526 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 479435012527 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435012528 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435012529 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435012530 Walker A/P-loop; other site 479435012531 ATP binding site [chemical binding]; other site 479435012532 Q-loop/lid; other site 479435012533 ABC transporter signature motif; other site 479435012534 Walker B; other site 479435012535 D-loop; other site 479435012536 H-loop/switch region; other site 479435012537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 479435012538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435012539 ABC-ATPase subunit interface; other site 479435012540 dimer interface [polypeptide binding]; other site 479435012541 putative PBP binding regions; other site 479435012542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435012543 ABC-ATPase subunit interface; other site 479435012544 dimer interface [polypeptide binding]; other site 479435012545 putative PBP binding regions; other site 479435012546 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 479435012547 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 479435012548 siderophore binding site; other site 479435012549 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 479435012550 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435012551 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 479435012552 dihydropteroate synthase; Region: DHPS; TIGR01496 479435012553 substrate binding pocket [chemical binding]; other site 479435012554 dimer interface [polypeptide binding]; other site 479435012555 inhibitor binding site; inhibition site 479435012556 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 479435012557 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435012558 putative active site pocket [active] 479435012559 metal binding site [ion binding]; metal-binding site 479435012560 classical (c) SDRs; Region: SDR_c; cd05233 479435012561 NAD(P) binding site [chemical binding]; other site 479435012562 active site 479435012563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435012564 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435012565 active site 479435012566 catalytic tetrad [active] 479435012567 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435012568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012569 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479435012570 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435012571 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435012572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435012573 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479435012574 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435012575 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 479435012576 active site 479435012577 metal binding site [ion binding]; metal-binding site 479435012578 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435012579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012580 Walker A/P-loop; other site 479435012581 ATP binding site [chemical binding]; other site 479435012582 Q-loop/lid; other site 479435012583 ABC transporter signature motif; other site 479435012584 Walker B; other site 479435012585 D-loop; other site 479435012586 H-loop/switch region; other site 479435012587 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435012588 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435012589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435012590 DNA-binding site [nucleotide binding]; DNA binding site 479435012591 FCD domain; Region: FCD; cl11656 479435012592 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479435012593 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479435012594 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 479435012595 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 479435012596 TPP-binding site [chemical binding]; other site 479435012597 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479435012598 Predicted ATPase [General function prediction only]; Region: COG3910 479435012599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012600 Walker A/P-loop; other site 479435012601 ATP binding site [chemical binding]; other site 479435012602 Q-loop/lid; other site 479435012603 ABC transporter signature motif; other site 479435012604 Walker B; other site 479435012605 D-loop; other site 479435012606 H-loop/switch region; other site 479435012607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435012608 dimerization interface [polypeptide binding]; other site 479435012609 putative DNA binding site [nucleotide binding]; other site 479435012610 putative Zn2+ binding site [ion binding]; other site 479435012611 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 479435012612 Transcription factor WhiB; Region: Whib; pfam02467 479435012613 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 479435012614 4Fe-4S binding domain; Region: Fer4; cl02805 479435012615 ferredoxin-NADP+ reductase; Region: PLN02852 479435012616 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 479435012617 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435012618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435012619 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435012620 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435012621 NAD(P) binding site [chemical binding]; other site 479435012622 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 479435012623 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479435012624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012625 NAD(P) binding pocket [chemical binding]; other site 479435012626 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435012627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435012628 substrate binding pocket [chemical binding]; other site 479435012629 membrane-bound complex binding site; other site 479435012630 hinge residues; other site 479435012631 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435012632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012633 dimer interface [polypeptide binding]; other site 479435012634 conserved gate region; other site 479435012635 putative PBP binding loops; other site 479435012636 ABC-ATPase subunit interface; other site 479435012637 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435012638 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 479435012639 Walker A/P-loop; other site 479435012640 ATP binding site [chemical binding]; other site 479435012641 Q-loop/lid; other site 479435012642 ABC transporter signature motif; other site 479435012643 Walker B; other site 479435012644 D-loop; other site 479435012645 H-loop/switch region; other site 479435012646 Predicted membrane protein [Function unknown]; Region: COG1470 479435012647 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435012648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435012650 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435012651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012652 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435012653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435012654 DNA binding residues [nucleotide binding] 479435012655 Transcription factor WhiB; Region: Whib; pfam02467 479435012656 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 479435012657 sensory histidine kinase DcuS; Provisional; Region: PRK11086 479435012658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435012659 Histidine kinase; Region: HisKA_2; cl06527 479435012660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012661 ATP binding site [chemical binding]; other site 479435012662 Mg2+ binding site [ion binding]; other site 479435012663 G-X-G motif; other site 479435012664 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 479435012665 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435012666 putative catalytic site [active] 479435012667 putative phosphate binding site [ion binding]; other site 479435012668 putative metal binding site [ion binding]; other site 479435012669 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 479435012670 Sodium:solute symporter family; Region: SSF; cl00456 479435012671 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 479435012672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435012673 Zn2+ binding site [ion binding]; other site 479435012674 Mg2+ binding site [ion binding]; other site 479435012675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435012678 TPR motif; other site 479435012679 binding surface 479435012680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435012681 binding surface 479435012682 TPR motif; other site 479435012683 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 479435012684 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 479435012685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435012687 DNA binding residues [nucleotide binding] 479435012688 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 479435012689 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 479435012690 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435012691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012692 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 479435012693 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 479435012694 Dimer interface [polypeptide binding]; other site 479435012695 anticodon binding site; other site 479435012696 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435012697 motif 1; other site 479435012698 dimer interface [polypeptide binding]; other site 479435012699 active site 479435012700 motif 2; other site 479435012701 motif 3; other site 479435012702 acetylornithine deacetylase; Validated; Region: PRK06915 479435012703 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 479435012704 metal binding site [ion binding]; metal-binding site 479435012705 dimer interface [polypeptide binding]; other site 479435012706 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 479435012707 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 479435012708 hinge; other site 479435012709 active site 479435012710 Predicted GTPases [General function prediction only]; Region: COG1162 479435012711 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 479435012712 GTPase/OB domain interface [polypeptide binding]; other site 479435012713 GTPase/Zn-binding domain interface [polypeptide binding]; other site 479435012714 GTP/Mg2+ binding site [chemical binding]; other site 479435012715 G4 box; other site 479435012716 G1 box; other site 479435012717 Switch I region; other site 479435012718 G2 box; other site 479435012719 G3 box; other site 479435012720 Switch II region; other site 479435012721 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 479435012722 active site 479435012723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012724 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435012725 NAD(P) binding site [chemical binding]; other site 479435012726 active site 479435012727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012729 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435012730 FOG: CBS domain [General function prediction only]; Region: COG0517 479435012731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 479435012732 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435012733 active site 479435012734 catalytic residues [active] 479435012735 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435012736 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435012737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435012738 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435012739 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435012740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012741 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435012742 putative substrate translocation pore; other site 479435012743 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435012744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012745 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435012746 DNA binding residues [nucleotide binding] 479435012747 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435012748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012749 dimer interface [polypeptide binding]; other site 479435012750 conserved gate region; other site 479435012751 putative PBP binding loops; other site 479435012752 ABC-ATPase subunit interface; other site 479435012753 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435012754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012755 dimer interface [polypeptide binding]; other site 479435012756 conserved gate region; other site 479435012757 putative PBP binding loops; other site 479435012758 ABC-ATPase subunit interface; other site 479435012759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435012760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435012762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012763 Phosphotransferase enzyme family; Region: APH; pfam01636 479435012764 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435012765 active site 479435012766 substrate binding site [chemical binding]; other site 479435012767 ATP binding site [chemical binding]; other site 479435012768 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435012769 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435012770 Walker A/P-loop; other site 479435012771 ATP binding site [chemical binding]; other site 479435012772 Q-loop/lid; other site 479435012773 ABC transporter signature motif; other site 479435012774 Walker B; other site 479435012775 D-loop; other site 479435012776 H-loop/switch region; other site 479435012777 FtsX-like permease family; Region: FtsX; pfam02687 479435012778 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435012779 FtsX-like permease family; Region: FtsX; pfam02687 479435012780 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435012781 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435012782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435012783 Histidine kinase; Region: HisKA_3; pfam07730 479435012784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435012786 DNA binding residues [nucleotide binding] 479435012787 dimerization interface [polypeptide binding]; other site 479435012788 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435012789 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435012790 NADP binding site [chemical binding]; other site 479435012791 homodimer interface [polypeptide binding]; other site 479435012792 active site 479435012793 substrate binding site [chemical binding]; other site 479435012794 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435012795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012796 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435012797 DinB superfamily; Region: DinB_2; cl00986 479435012798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435012800 dimerization interface [polypeptide binding]; other site 479435012801 putative DNA binding site [nucleotide binding]; other site 479435012802 putative Zn2+ binding site [ion binding]; other site 479435012803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012804 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 479435012805 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435012806 putative dimerization interface [polypeptide binding]; other site 479435012807 putative ligand binding site [chemical binding]; other site 479435012808 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 479435012809 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 479435012810 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012812 dimer interface [polypeptide binding]; other site 479435012813 conserved gate region; other site 479435012814 putative PBP binding loops; other site 479435012815 ABC-ATPase subunit interface; other site 479435012816 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435012817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012818 putative PBP binding loops; other site 479435012819 dimer interface [polypeptide binding]; other site 479435012820 ABC-ATPase subunit interface; other site 479435012821 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435012823 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435012824 active site 479435012825 metal binding site [ion binding]; metal-binding site 479435012826 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 479435012827 DNA binding residues [nucleotide binding] 479435012828 drug binding residues [chemical binding]; other site 479435012829 dimer interface [polypeptide binding]; other site 479435012830 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 479435012831 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 479435012832 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 479435012833 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435012834 putative sugar binding sites [chemical binding]; other site 479435012835 Q-X-W motif; other site 479435012836 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 479435012837 active site 479435012838 catalytic residues [active] 479435012839 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435012840 putative sugar binding sites [chemical binding]; other site 479435012841 Q-X-W motif; other site 479435012842 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435012843 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435012844 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435012845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012847 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435012848 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 479435012849 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 479435012850 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435012851 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435012852 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435012853 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435012854 DNA binding site [nucleotide binding] 479435012855 domain linker motif; other site 479435012856 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435012857 dimerization interface [polypeptide binding]; other site 479435012858 ligand binding site [chemical binding]; other site 479435012859 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435012860 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 479435012861 substrate binding site [chemical binding]; other site 479435012862 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435012863 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435012864 Walker A/P-loop; other site 479435012865 ATP binding site [chemical binding]; other site 479435012866 Q-loop/lid; other site 479435012867 ABC transporter signature motif; other site 479435012868 Walker B; other site 479435012869 D-loop; other site 479435012870 H-loop/switch region; other site 479435012871 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012872 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435012873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012874 dimer interface [polypeptide binding]; other site 479435012875 conserved gate region; other site 479435012876 putative PBP binding loops; other site 479435012877 ABC-ATPase subunit interface; other site 479435012878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435012879 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435012880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435012881 dimer interface [polypeptide binding]; other site 479435012882 conserved gate region; other site 479435012883 putative PBP binding loops; other site 479435012884 ABC-ATPase subunit interface; other site 479435012885 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435012886 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435012887 Walker A/P-loop; other site 479435012888 ATP binding site [chemical binding]; other site 479435012889 Q-loop/lid; other site 479435012890 ABC transporter signature motif; other site 479435012891 Walker B; other site 479435012892 D-loop; other site 479435012893 H-loop/switch region; other site 479435012894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012895 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 479435012896 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 479435012897 DinB superfamily; Region: DinB_2; cl00986 479435012898 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435012899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435012900 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 479435012901 putative active site [active] 479435012902 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435012903 catalytic site [active] 479435012904 Asp-box motif; other site 479435012905 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 479435012906 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435012907 ligand binding site [chemical binding]; other site 479435012908 flexible hinge region; other site 479435012909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012910 ATP binding site [chemical binding]; other site 479435012911 Mg2+ binding site [ion binding]; other site 479435012912 G-X-G motif; other site 479435012913 Response regulator receiver domain; Region: Response_reg; pfam00072 479435012914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435012915 active site 479435012916 phosphorylation site [posttranslational modification] 479435012917 intermolecular recognition site; other site 479435012918 dimerization interface [polypeptide binding]; other site 479435012919 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479435012920 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435012921 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 479435012922 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 479435012923 putative active site [active] 479435012924 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 479435012925 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 479435012926 homodimer interface [polypeptide binding]; other site 479435012927 substrate-cofactor binding pocket; other site 479435012928 catalytic residue [active] 479435012929 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479435012930 nucleotide binding site [chemical binding]; other site 479435012931 FemAB family; Region: FemAB; cl11444 479435012932 FemAB family; Region: FemAB; cl11444 479435012933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012934 Active site [active] 479435012935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012936 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435012937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012938 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435012939 Walker A/P-loop; other site 479435012940 ATP binding site [chemical binding]; other site 479435012941 Q-loop/lid; other site 479435012942 ABC transporter signature motif; other site 479435012943 Walker B; other site 479435012944 D-loop; other site 479435012945 H-loop/switch region; other site 479435012946 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435012947 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 479435012948 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435012949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435012950 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435012951 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435012952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012953 Walker A/P-loop; other site 479435012954 ATP binding site [chemical binding]; other site 479435012955 Q-loop/lid; other site 479435012956 ABC transporter signature motif; other site 479435012957 Walker B; other site 479435012958 D-loop; other site 479435012959 H-loop/switch region; other site 479435012960 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435012961 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435012962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435012963 Walker A/P-loop; other site 479435012964 ATP binding site [chemical binding]; other site 479435012965 Q-loop/lid; other site 479435012966 ABC transporter signature motif; other site 479435012967 Walker B; other site 479435012968 D-loop; other site 479435012969 H-loop/switch region; other site 479435012970 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435012971 active site 479435012972 catalytic residues [active] 479435012973 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435012974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435012976 DNA binding residues [nucleotide binding] 479435012977 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 479435012978 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 479435012979 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 479435012980 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 479435012981 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 479435012982 MoaE homodimer interface [polypeptide binding]; other site 479435012983 MoaD interaction [polypeptide binding]; other site 479435012984 active site residues [active] 479435012985 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 479435012986 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 479435012987 nudix motif; other site 479435012988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435012989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435012990 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435012991 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435012992 putative NAD(P) binding site [chemical binding]; other site 479435012993 GAF domain; Region: GAF; cl00853 479435012994 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 479435012995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012996 metabolite-proton symporter; Region: 2A0106; TIGR00883 479435012997 putative substrate translocation pore; other site 479435012998 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 479435012999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013000 NAD(P) binding site [chemical binding]; other site 479435013001 active site 479435013002 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 479435013003 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 479435013004 putative molybdopterin cofactor binding site [chemical binding]; other site 479435013005 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 479435013006 putative molybdopterin cofactor binding site; other site 479435013007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435013009 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435013010 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435013011 Protein of unknown function DUF45; Region: DUF45; cl00636 479435013012 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 479435013013 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435013014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435013015 active site 479435013016 ATP binding site [chemical binding]; other site 479435013017 Transcription factor WhiB; Region: Whib; pfam02467 479435013018 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435013019 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479435013020 HRDC domain; Region: HRDC; cl02578 479435013021 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 479435013022 catalytic residues [active] 479435013023 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 479435013024 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 479435013025 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 479435013026 putative NADH binding site [chemical binding]; other site 479435013027 putative active site [active] 479435013028 nudix motif; other site 479435013029 putative metal binding site [ion binding]; other site 479435013030 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 479435013031 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 479435013032 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435013033 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 479435013034 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435013035 IucA / IucC family; Region: IucA_IucC; pfam04183 479435013036 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435013037 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435013038 putative active site [active] 479435013039 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435013040 putative active site [active] 479435013041 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435013042 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479435013043 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435013044 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479435013045 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435013046 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 479435013047 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435013048 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435013049 DNA binding site [nucleotide binding] 479435013050 active site 479435013051 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435013052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435013053 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 479435013054 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 479435013055 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 479435013056 ATP binding site [chemical binding]; other site 479435013057 substrate interface [chemical binding]; other site 479435013058 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479435013059 active site residue [active] 479435013060 Calx-beta domain; Region: Calx-beta; cl02522 479435013061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435013062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435013063 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 479435013064 nucleotide binding site [chemical binding]; other site 479435013065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013067 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 479435013068 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435013069 dinuclear metal binding motif [ion binding]; other site 479435013070 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 479435013071 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435013072 ATP binding site [chemical binding]; other site 479435013073 Mg++ binding site [ion binding]; other site 479435013074 motif III; other site 479435013075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435013076 nucleotide binding region [chemical binding]; other site 479435013077 ATP-binding site [chemical binding]; other site 479435013078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435013079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435013080 P-loop; other site 479435013081 Magnesium ion binding site [ion binding]; other site 479435013082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435013083 Magnesium ion binding site [ion binding]; other site 479435013084 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435013085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013086 putative substrate translocation pore; other site 479435013087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013088 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435013089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435013090 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435013091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435013093 DNA binding residues [nucleotide binding] 479435013094 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 479435013095 metal binding triad [ion binding]; metal-binding site 479435013096 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435013097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013098 Walker A/P-loop; other site 479435013099 ATP binding site [chemical binding]; other site 479435013100 Q-loop/lid; other site 479435013101 ABC transporter signature motif; other site 479435013102 Walker B; other site 479435013103 D-loop; other site 479435013104 H-loop/switch region; other site 479435013105 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 479435013106 Protein of unknown function (DUF990); Region: DUF990; cl01496 479435013107 Protein of unknown function (DUF990); Region: DUF990; cl01496 479435013108 MarC family integral membrane protein; Region: MarC; cl00919 479435013109 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 479435013110 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435013111 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435013112 nudix motif; other site 479435013113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435013114 GAF domain; Region: GAF; cl00853 479435013115 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435013116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435013117 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435013118 anti sigma factor interaction site; other site 479435013119 regulatory phosphorylation site [posttranslational modification]; other site 479435013120 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435013121 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435013122 catalytic core [active] 479435013123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435013124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435013125 DNA binding site [nucleotide binding] 479435013126 domain linker motif; other site 479435013127 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435013128 ligand binding site [chemical binding]; other site 479435013129 dimerization interface [polypeptide binding]; other site 479435013130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435013133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435013135 dimer interface [polypeptide binding]; other site 479435013136 conserved gate region; other site 479435013137 putative PBP binding loops; other site 479435013138 ABC-ATPase subunit interface; other site 479435013139 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 479435013140 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 479435013141 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 479435013142 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 479435013143 putative active site [active] 479435013144 putative catalytic site [active] 479435013145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013146 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435013147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435013149 binding surface 479435013150 TPR motif; other site 479435013151 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435013152 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 479435013153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435013154 putative DNA binding site [nucleotide binding]; other site 479435013155 putative Zn2+ binding site [ion binding]; other site 479435013156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435013157 dimerization interface [polypeptide binding]; other site 479435013158 putative DNA binding site [nucleotide binding]; other site 479435013159 putative Zn2+ binding site [ion binding]; other site 479435013160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435013161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435013162 active site 479435013163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435013164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435013165 active site 479435013166 ATP binding site [chemical binding]; other site 479435013167 substrate binding site [chemical binding]; other site 479435013168 activation loop (A-loop); other site 479435013169 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435013170 active site 479435013171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435013172 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435013173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435013175 DNA binding residues [nucleotide binding] 479435013176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013178 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 479435013179 MgtE intracellular N domain; Region: MgtE_N; cl15244 479435013180 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 479435013181 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 479435013182 Domain of unknown function DUF59; Region: DUF59; cl00941 479435013183 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 479435013184 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 479435013185 Walker A motif; other site 479435013186 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435013187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013188 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435013189 active site 479435013190 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 479435013191 dimer interface [polypeptide binding]; other site 479435013192 active site 479435013193 ADP-ribose binding site [chemical binding]; other site 479435013194 nudix motif; other site 479435013195 metal binding site [ion binding]; metal-binding site 479435013196 CTP synthetase; Validated; Region: pyrG; PRK05380 479435013197 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 479435013198 Catalytic site [active] 479435013199 Active site [active] 479435013200 UTP binding site [chemical binding]; other site 479435013201 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 479435013202 active site 479435013203 putative oxyanion hole; other site 479435013204 catalytic triad [active] 479435013205 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479435013206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435013207 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 479435013208 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 479435013209 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 479435013210 Thiamine pyrophosphokinase; Region: TPK; cl09135 479435013211 active site 479435013212 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 479435013213 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 479435013214 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 479435013215 Walker A/P-loop; other site 479435013216 ATP binding site [chemical binding]; other site 479435013217 Q-loop/lid; other site 479435013218 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 479435013219 ABC transporter signature motif; other site 479435013220 Walker B; other site 479435013221 D-loop; other site 479435013222 H-loop/switch region; other site 479435013223 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 479435013224 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 479435013225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435013226 phosphoglycolate/pyridoxal phosphate phosphatase family; Region: PGP_euk; TIGR01452 479435013227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435013228 motif II; other site 479435013229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435013230 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 479435013231 tetratricopeptide repeat protein; Provisional; Region: PRK11788 479435013232 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 479435013233 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 479435013234 active site 479435013235 HIGH motif; other site 479435013236 dimer interface [polypeptide binding]; other site 479435013237 KMSKS motif; other site 479435013238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 479435013239 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 479435013240 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435013241 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435013242 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 479435013243 active site 479435013244 DNA binding site [nucleotide binding] 479435013245 argininosuccinate lyase; Provisional; Region: PRK00855 479435013246 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 479435013247 active sites [active] 479435013248 tetramer interface [polypeptide binding]; other site 479435013249 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 479435013250 Arginine repressor [Transcription]; Region: ArgR; COG1438 479435013251 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 479435013252 ornithine carbamoyltransferase; Provisional; Region: PRK00779 479435013253 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479435013254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013255 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 479435013256 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 479435013257 inhibitor-cofactor binding pocket; inhibition site 479435013258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013259 catalytic residue [active] 479435013260 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 479435013261 feedback inhibition sensing region; other site 479435013262 homohexameric interface [polypeptide binding]; other site 479435013263 nucleotide binding site [chemical binding]; other site 479435013264 N-acetyl-L-glutamate binding site [chemical binding]; other site 479435013265 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 479435013266 heterotetramer interface [polypeptide binding]; other site 479435013267 active site pocket [active] 479435013268 cleavage site 479435013269 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 479435013270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013271 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 479435013272 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 479435013273 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 479435013274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435013276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435013277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435013278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013279 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435013280 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435013281 Ligand binding site [chemical binding]; other site 479435013282 Putative Catalytic site [active] 479435013283 DXD motif; other site 479435013284 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479435013285 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435013286 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 479435013287 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 479435013288 putative tRNA-binding site [nucleotide binding]; other site 479435013289 B3/4 domain; Region: B3_4; cl11458 479435013290 tRNA synthetase B5 domain; Region: B5; cl08394 479435013291 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 479435013292 dimer interface [polypeptide binding]; other site 479435013293 motif 1; other site 479435013294 motif 3; other site 479435013295 motif 2; other site 479435013296 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 479435013297 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 479435013298 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 479435013299 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 479435013300 dimer interface [polypeptide binding]; other site 479435013301 motif 1; other site 479435013302 active site 479435013303 motif 2; other site 479435013304 motif 3; other site 479435013305 Vitamin K epoxide reductase family; Region: VKOR; cl01729 479435013306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435013307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013308 putative substrate translocation pore; other site 479435013309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013310 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479435013311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013312 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435013313 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435013314 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 479435013315 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435013316 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 479435013317 23S rRNA binding site [nucleotide binding]; other site 479435013318 L21 binding site [polypeptide binding]; other site 479435013319 L13 binding site [polypeptide binding]; other site 479435013320 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 479435013321 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 479435013322 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 479435013323 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 479435013324 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435013325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013327 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435013328 active site 479435013329 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435013330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435013332 dimer interface [polypeptide binding]; other site 479435013333 conserved gate region; other site 479435013334 putative PBP binding loops; other site 479435013335 ABC-ATPase subunit interface; other site 479435013336 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435013337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435013338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435013341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435013342 DNA binding site [nucleotide binding] 479435013343 domain linker motif; other site 479435013344 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435013345 ligand binding site [chemical binding]; other site 479435013346 dimerization interface [polypeptide binding]; other site 479435013347 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435013348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013349 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435013350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435013351 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435013352 Walker A/P-loop; other site 479435013353 ATP binding site [chemical binding]; other site 479435013354 Q-loop/lid; other site 479435013355 ABC transporter signature motif; other site 479435013356 Walker B; other site 479435013357 D-loop; other site 479435013358 H-loop/switch region; other site 479435013359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013360 Active site [active] 479435013361 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 479435013362 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 479435013363 active site 479435013364 catalytic residues [active] 479435013365 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 479435013366 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 479435013367 ATP phosphoribosyltransferase; Region: HisG; cl15266 479435013368 HisG, C-terminal domain; Region: HisG_C; cl06867 479435013369 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 479435013370 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 479435013371 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435013372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 479435013373 protein binding site [polypeptide binding]; other site 479435013374 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 479435013375 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 479435013376 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435013377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435013379 DNA binding residues [nucleotide binding] 479435013380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 479435013381 carboxyltransferase (CT) interaction site; other site 479435013382 biotinylation site [posttranslational modification]; other site 479435013383 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435013384 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435013385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013386 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435013387 active site 479435013388 dimer interface [polypeptide binding]; other site 479435013389 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435013390 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435013391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013392 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435013393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435013394 S-adenosylmethionine binding site [chemical binding]; other site 479435013395 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435013396 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 479435013397 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435013398 Cupin domain; Region: Cupin_2; cl09118 479435013399 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435013400 homotrimer interaction site [polypeptide binding]; other site 479435013401 putative active site [active] 479435013402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435013403 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 479435013404 NAD binding site [chemical binding]; other site 479435013405 catalytic residues [active] 479435013406 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 479435013407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013409 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435013410 kynureninase; Region: kynureninase; TIGR01814 479435013411 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 479435013412 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 479435013413 ligand binding site [chemical binding]; other site 479435013414 oligomer interface [polypeptide binding]; other site 479435013415 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 479435013416 dimer interface [polypeptide binding]; other site 479435013417 N-terminal domain interface [polypeptide binding]; other site 479435013418 sulfate 1 binding site; other site 479435013419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013420 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479435013421 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435013422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435013423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435013424 active site 479435013425 catalytic tetrad [active] 479435013426 multifunctional aminopeptidase A; Provisional; Region: PRK00913 479435013427 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 479435013428 interface (dimer of trimers) [polypeptide binding]; other site 479435013429 Substrate-binding/catalytic site; other site 479435013430 Zn-binding sites [ion binding]; other site 479435013431 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 479435013432 PaaX-like protein; Region: PaaX; pfam07848 479435013433 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 479435013434 enoyl-CoA hydratase; Provisional; Region: PRK06688 479435013435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 479435013436 substrate binding site [chemical binding]; other site 479435013437 oxyanion hole (OAH) forming residues; other site 479435013438 trimer interface [polypeptide binding]; other site 479435013439 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 479435013440 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 479435013441 DivIVA domain; Region: DivI1A_domain; TIGR03544 479435013442 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 479435013443 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 479435013444 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 479435013445 metal binding site [ion binding]; metal-binding site 479435013446 putative dimer interface [polypeptide binding]; other site 479435013447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435013448 active site 479435013449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435013450 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435013451 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435013452 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 479435013453 DinB superfamily; Region: DinB_2; cl00986 479435013454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435013455 dimer interface [polypeptide binding]; other site 479435013456 conserved gate region; other site 479435013457 putative PBP binding loops; other site 479435013458 ABC-ATPase subunit interface; other site 479435013459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013460 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 479435013461 putative active site [active] 479435013462 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435013463 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 479435013464 substrate binding site [chemical binding]; other site 479435013465 dimer interface [polypeptide binding]; other site 479435013466 ATP binding site [chemical binding]; other site 479435013467 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435013468 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435013469 DNA binding site [nucleotide binding] 479435013470 domain linker motif; other site 479435013471 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435013472 ligand binding site [chemical binding]; other site 479435013473 dimerization interface [polypeptide binding]; other site 479435013474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013475 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479435013476 NAD(P) binding site [chemical binding]; other site 479435013477 active site 479435013478 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435013479 active site 479435013480 substrate binding site [chemical binding]; other site 479435013481 Phosphotransferase enzyme family; Region: APH; pfam01636 479435013482 ATP binding site [chemical binding]; other site 479435013483 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 479435013484 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 479435013485 putative trimer interface [polypeptide binding]; other site 479435013486 putative CoA binding site [chemical binding]; other site 479435013487 Ferredoxin [Energy production and conversion]; Region: COG1146 479435013488 4Fe-4S binding domain; Region: Fer4; cl02805 479435013489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013490 short chain dehydrogenase; Provisional; Region: PRK08219 479435013491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013492 NAD(P) binding site [chemical binding]; other site 479435013493 active site 479435013494 PemK-like protein; Region: PemK; cl00995 479435013495 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 479435013496 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 479435013497 VanW like protein; Region: VanW; pfam04294 479435013498 Flavin Reductases; Region: FlaRed; cl00801 479435013499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435013500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435013502 binding surface 479435013503 TPR motif; other site 479435013504 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435013505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435013506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435013508 binding surface 479435013509 TPR motif; other site 479435013510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435013511 binding surface 479435013512 TPR motif; other site 479435013513 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 479435013514 active site 479435013515 8-oxo-dGMP binding site [chemical binding]; other site 479435013516 nudix motif; other site 479435013517 metal binding site [ion binding]; metal-binding site 479435013518 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 479435013519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013520 domain; Region: Succ_DH_flav_C; pfam02910 479435013521 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 479435013522 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435013523 catalytic loop [active] 479435013524 iron binding site [ion binding]; other site 479435013525 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435013526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013527 oxidoreductase; Provisional; Region: PRK12743 479435013528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013529 NAD(P) binding site [chemical binding]; other site 479435013530 active site 479435013531 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 479435013532 aromatic arch; other site 479435013533 DCoH dimer interaction site [polypeptide binding]; other site 479435013534 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 479435013535 DCoH tetramer interaction site [polypeptide binding]; other site 479435013536 substrate binding site [chemical binding]; other site 479435013537 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435013538 Cytochrome P450; Region: p450; cl12078 479435013539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435013540 dimerization interface [polypeptide binding]; other site 479435013541 putative DNA binding site [nucleotide binding]; other site 479435013542 putative Zn2+ binding site [ion binding]; other site 479435013543 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435013544 putative hydrophobic ligand binding site [chemical binding]; other site 479435013545 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435013546 conserved cys residue [active] 479435013547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435013549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435013551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435013552 S-adenosylmethionine binding site [chemical binding]; other site 479435013553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013554 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435013555 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479435013556 dimer interface [polypeptide binding]; other site 479435013557 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435013558 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 479435013559 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 479435013560 catalytic residues [active] 479435013561 catalytic nucleophile [active] 479435013562 Recombinase; Region: Recombinase; pfam07508 479435013563 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435013564 nucleotide binding site [chemical binding]; other site 479435013565 polymerase nucleotide-binding site; other site 479435013566 primase nucleotide-binding site [nucleotide binding]; other site 479435013567 DNA-binding residues [nucleotide binding]; DNA binding site 479435013568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435013570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435013571 GTP-binding protein YchF; Reviewed; Region: PRK09601 479435013572 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 479435013573 G1 box; other site 479435013574 GTP/Mg2+ binding site [chemical binding]; other site 479435013575 Switch I region; other site 479435013576 G2 box; other site 479435013577 Switch II region; other site 479435013578 G3 box; other site 479435013579 G4 box; other site 479435013580 G5 box; other site 479435013581 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 479435013582 Protein of unknown function (DUF817); Region: DUF817; cl01520 479435013583 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435013584 RmuC family; Region: RmuC; pfam02646 479435013585 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 479435013586 substrate binding pocket [chemical binding]; other site 479435013587 catalytic residues [active] 479435013588 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435013589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435013591 DNA binding residues [nucleotide binding] 479435013592 LytB protein; Region: LYTB; cl00507 479435013593 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 479435013594 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 479435013595 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 479435013596 generic binding surface II; other site 479435013597 generic binding surface I; other site 479435013598 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 479435013599 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435013600 active site 479435013601 metal binding site [ion binding]; metal-binding site 479435013602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013603 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435013604 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 479435013605 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435013606 active site 479435013607 ATP binding site [chemical binding]; other site 479435013608 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 479435013609 Ligand binding site [chemical binding]; other site 479435013610 metal binding site [ion binding]; metal-binding site 479435013611 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 479435013612 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 479435013613 putative active site [active] 479435013614 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435013615 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 479435013616 putative substrate binding site [chemical binding]; other site 479435013617 putative ATP binding site [chemical binding]; other site 479435013618 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435013619 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 479435013620 fumarate hydratase; Provisional; Region: PRK15389 479435013621 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 479435013622 Fumarase C-terminus; Region: Fumerase_C; cl00795 479435013623 Cupin domain; Region: Cupin_2; cl09118 479435013624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435013626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013627 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435013628 classical (c) SDRs; Region: SDR_c; cd05233 479435013629 NAD(P) binding site [chemical binding]; other site 479435013630 active site 479435013631 Protein of unknown function (DUF402); Region: DUF402; cl00979 479435013632 fumarate hydratase; Reviewed; Region: fumC; PRK00485 479435013633 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 479435013634 active sites [active] 479435013635 tetramer interface [polypeptide binding]; other site 479435013636 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 479435013637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435013638 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 479435013639 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435013640 catalytic residue [active] 479435013641 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 479435013642 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 479435013643 putative active site [active] 479435013644 PhoH-like protein; Region: PhoH; cl12134 479435013645 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 479435013646 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 479435013647 catalytic residue [active] 479435013648 putative FPP diphosphate binding site; other site 479435013649 putative FPP binding hydrophobic cleft; other site 479435013650 dimer interface [polypeptide binding]; other site 479435013651 putative IPP diphosphate binding site; other site 479435013652 Haemolysin-III related; Region: HlyIII; cl03831 479435013653 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435013654 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 479435013655 active site 479435013656 metal binding site [ion binding]; metal-binding site 479435013657 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435013658 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435013659 active site 479435013660 Zn binding site [ion binding]; other site 479435013661 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 479435013662 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 479435013663 catalytic residues [active] 479435013664 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 479435013665 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435013666 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 479435013667 domain; Region: GreA_GreB_N; pfam03449 479435013668 C-term; Region: GreA_GreB; pfam01272 479435013669 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435013670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013671 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435013672 Walker A/P-loop; other site 479435013673 ATP binding site [chemical binding]; other site 479435013674 Q-loop/lid; other site 479435013675 ABC transporter signature motif; other site 479435013676 Walker B; other site 479435013677 D-loop; other site 479435013678 H-loop/switch region; other site 479435013679 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435013680 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435013681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435013682 active site 479435013683 ATP binding site [chemical binding]; other site 479435013684 substrate binding site [chemical binding]; other site 479435013685 activation loop (A-loop); other site 479435013686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435013687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435013690 dimer interface [polypeptide binding]; other site 479435013691 conserved gate region; other site 479435013692 putative PBP binding loops; other site 479435013693 ABC-ATPase subunit interface; other site 479435013694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435013695 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435013696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013697 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013698 threonine dehydratase; Provisional; Region: PRK08198 479435013699 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435013700 tetramer interface [polypeptide binding]; other site 479435013701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013702 catalytic residue [active] 479435013703 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 479435013704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435013705 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435013706 active site 479435013707 catalytic tetrad [active] 479435013708 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435013709 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435013710 nodulation ABC transporter NodI; Provisional; Region: PRK13537 479435013711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435013712 Walker A/P-loop; other site 479435013713 ATP binding site [chemical binding]; other site 479435013714 Q-loop/lid; other site 479435013715 ABC transporter signature motif; other site 479435013716 Walker B; other site 479435013717 D-loop; other site 479435013718 H-loop/switch region; other site 479435013719 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435013720 classical (c) SDRs; Region: SDR_c; cd05233 479435013721 NAD(P) binding site [chemical binding]; other site 479435013722 active site 479435013723 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435013724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013725 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435013726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013727 putative substrate translocation pore; other site 479435013728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013729 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479435013730 Domain of unknown function DUF20; Region: UPF0118; cl00465 479435013731 conserved hypothetical protein; Region: glmL_fam; TIGR01319 479435013732 cystathionine gamma-synthase; Provisional; Region: PRK07811 479435013733 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479435013734 homodimer interface [polypeptide binding]; other site 479435013735 substrate-cofactor binding pocket; other site 479435013736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013737 catalytic residue [active] 479435013738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013740 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435013741 Predicted membrane protein [Function unknown]; Region: COG2364 479435013742 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 479435013743 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435013744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435013745 DNA-binding site [nucleotide binding]; DNA binding site 479435013746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435013747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013748 homodimer interface [polypeptide binding]; other site 479435013749 catalytic residue [active] 479435013750 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 479435013751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435013752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435013753 S-adenosylmethionine binding site [chemical binding]; other site 479435013754 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435013755 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435013756 active site 479435013757 NTP binding site [chemical binding]; other site 479435013758 metal binding triad [ion binding]; metal-binding site 479435013759 antibiotic binding site [chemical binding]; other site 479435013760 DinB superfamily; Region: DinB_2; cl00986 479435013761 Protein of unknown function DUF99; Region: DUF99; cl00704 479435013762 DinB superfamily; Region: DinB_2; cl00986 479435013763 DinB superfamily; Region: DinB_2; cl00986 479435013764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435013765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435013766 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 479435013767 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 479435013768 nucleotide binding site/active site [active] 479435013769 HIT family signature motif; other site 479435013770 catalytic residue [active] 479435013771 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 479435013772 phospholipase D; Region: PLN02866 479435013773 putative active site [active] 479435013774 catalytic site [active] 479435013775 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 479435013776 putative active site [active] 479435013777 catalytic site [active] 479435013778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435013779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435013780 DNA binding site [nucleotide binding] 479435013781 domain linker motif; other site 479435013782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435013783 dimerization interface [polypeptide binding]; other site 479435013784 ligand binding site [chemical binding]; other site 479435013785 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435013786 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435013787 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435013788 NADP binding site [chemical binding]; other site 479435013789 homodimer interface [polypeptide binding]; other site 479435013790 active site 479435013791 substrate binding site [chemical binding]; other site 479435013792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013794 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 479435013795 Uncharacterized conserved protein [Function unknown]; Region: COG3875 479435013796 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435013797 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 479435013798 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 479435013799 dimer interface [polypeptide binding]; other site 479435013800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013801 catalytic residue [active] 479435013802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 479435013803 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 479435013804 active site 479435013805 catalytic triad [active] 479435013806 oxyanion hole [active] 479435013807 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 479435013808 Cupin domain; Region: Cupin_2; cl09118 479435013809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013810 NAD(P) binding site [chemical binding]; other site 479435013811 active site 479435013812 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435013813 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 479435013814 heme bH binding site [chemical binding]; other site 479435013815 intrachain domain interface; other site 479435013816 heme bL binding site [chemical binding]; other site 479435013817 interchain domain interface [polypeptide binding]; other site 479435013818 Qo binding site; other site 479435013819 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435013820 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435013821 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 479435013822 active site 479435013823 catalytic residues [active] 479435013824 metal binding site [ion binding]; metal-binding site 479435013825 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 479435013826 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435013827 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435013828 Histidine kinase; Region: HisKA_3; pfam07730 479435013829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435013830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435013831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435013832 active site 479435013833 phosphorylation site [posttranslational modification] 479435013834 intermolecular recognition site; other site 479435013835 dimerization interface [polypeptide binding]; other site 479435013836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435013837 dimerization interface [polypeptide binding]; other site 479435013838 DNA binding residues [nucleotide binding] 479435013839 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 479435013840 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 479435013841 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435013842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013843 Cupin domain; Region: Cupin_2; cl09118 479435013844 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 479435013845 Fe-S cluster binding site [ion binding]; other site 479435013846 DNA binding site [nucleotide binding] 479435013847 active site 479435013848 exopolyphosphatase; Region: exo_poly_only; TIGR03706 479435013849 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 479435013850 Protein of unknown function (DUF501); Region: DUF501; cl00652 479435013851 Septum formation initiator; Region: DivIC; cl11433 479435013852 enolase; Provisional; Region: eno; PRK00077 479435013853 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 479435013854 dimer interface [polypeptide binding]; other site 479435013855 metal binding site [ion binding]; metal-binding site 479435013856 substrate binding pocket [chemical binding]; other site 479435013857 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 479435013858 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 479435013859 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 479435013860 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 479435013861 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 479435013862 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 479435013863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435013864 ATP binding site [chemical binding]; other site 479435013865 putative Mg++ binding site [ion binding]; other site 479435013866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435013867 nucleotide binding region [chemical binding]; other site 479435013868 ATP-binding site [chemical binding]; other site 479435013869 TRCF domain; Region: TRCF; cl04088 479435013870 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 479435013871 putative active site [active] 479435013872 catalytic residue [active] 479435013873 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 479435013874 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 479435013875 5S rRNA interface [nucleotide binding]; other site 479435013876 CTC domain interface [polypeptide binding]; other site 479435013877 L16 interface [polypeptide binding]; other site 479435013878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013879 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 479435013880 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435013881 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 479435013882 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 479435013883 Substrate binding site [chemical binding]; other site 479435013884 Mg++ binding site [ion binding]; other site 479435013885 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 479435013886 active site 479435013887 substrate binding site [chemical binding]; other site 479435013888 CoA binding site [chemical binding]; other site 479435013889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435013890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435013891 active site 479435013892 phosphorylation site [posttranslational modification] 479435013893 intermolecular recognition site; other site 479435013894 dimerization interface [polypeptide binding]; other site 479435013895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435013896 DNA binding residues [nucleotide binding] 479435013897 dimerization interface [polypeptide binding]; other site 479435013898 Histidine kinase; Region: HisKA_3; pfam07730 479435013899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435013900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013901 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 479435013902 Di-iron ligands [ion binding]; other site 479435013903 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 479435013904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435013905 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435013906 Walker A/P-loop; other site 479435013907 ATP binding site [chemical binding]; other site 479435013908 Q-loop/lid; other site 479435013909 ABC transporter signature motif; other site 479435013910 Walker B; other site 479435013911 D-loop; other site 479435013912 H-loop/switch region; other site 479435013913 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435013914 FtsX-like permease family; Region: FtsX; pfam02687 479435013915 FtsX-like permease family; Region: FtsX; pfam02687 479435013916 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435013917 active site 479435013918 metal binding site [ion binding]; metal-binding site 479435013919 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 479435013920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435013921 S-adenosylmethionine binding site [chemical binding]; other site 479435013922 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435013923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435013924 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435013925 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435013926 ABC transporter; Region: ABC_tran_2; pfam12848 479435013927 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435013928 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435013929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435013930 S-adenosylmethionine binding site [chemical binding]; other site 479435013931 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 479435013932 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 479435013933 G1 box; other site 479435013934 putative GEF interaction site [polypeptide binding]; other site 479435013935 GTP/Mg2+ binding site [chemical binding]; other site 479435013936 Switch I region; other site 479435013937 G2 box; other site 479435013938 G3 box; other site 479435013939 Switch II region; other site 479435013940 G4 box; other site 479435013941 G5 box; other site 479435013942 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 479435013943 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 479435013944 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 479435013945 Domain of unknown function (DUF407); Region: DUF407; pfam04174 479435013946 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435013947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435013949 DNA binding residues [nucleotide binding] 479435013950 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 479435013951 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 479435013952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435013953 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479435013954 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479435013955 G5 domain; Region: G5; pfam07501 479435013956 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435013957 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479435013958 FMN binding site [chemical binding]; other site 479435013959 dimer interface [polypeptide binding]; other site 479435013960 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 479435013961 active site 479435013962 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 479435013963 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 479435013964 active site 479435013965 HIGH motif; other site 479435013966 KMSKS motif; other site 479435013967 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 479435013968 tRNA binding surface [nucleotide binding]; other site 479435013969 anticodon binding site; other site 479435013970 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 479435013971 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 479435013972 active site 479435013973 HIGH motif; other site 479435013974 KMSKS motif; other site 479435013975 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 479435013976 tRNA binding surface [nucleotide binding]; other site 479435013977 anticodon binding site; other site 479435013978 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435013979 Predicted methyltransferases [General function prediction only]; Region: COG0313 479435013980 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 479435013981 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 479435013982 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435013983 Domain of unknown function (DUF364); Region: DUF364; cl00885 479435013984 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435013985 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 479435013986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435013987 catalytic residue [active] 479435013988 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 479435013989 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435013990 Walker A/P-loop; other site 479435013991 ATP binding site [chemical binding]; other site 479435013992 Q-loop/lid; other site 479435013993 ABC transporter signature motif; other site 479435013994 Walker B; other site 479435013995 D-loop; other site 479435013996 H-loop/switch region; other site 479435013997 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 479435013998 Walker A/P-loop; other site 479435013999 ATP binding site [chemical binding]; other site 479435014000 Q-loop/lid; other site 479435014001 ABC transporter signature motif; other site 479435014002 Walker B; other site 479435014003 D-loop; other site 479435014004 H-loop/switch region; other site 479435014005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435014006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435014007 dimer interface [polypeptide binding]; other site 479435014008 conserved gate region; other site 479435014009 putative PBP binding loops; other site 479435014010 ABC-ATPase subunit interface; other site 479435014011 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 479435014012 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435014013 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435014014 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435014015 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435014016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014017 Copper resistance protein D; Region: CopD; cl00563 479435014018 Copper resistance protein CopC; Region: CopC; cl01012 479435014019 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 479435014020 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479435014021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435014022 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435014023 anti sigma factor interaction site; other site 479435014024 regulatory phosphorylation site [posttranslational modification]; other site 479435014025 Transport protein; Region: actII; TIGR00833 479435014026 Transport protein; Region: actII; TIGR00833 479435014027 Histidine kinase; Region: HisKA_3; pfam07730 479435014028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435014029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435014030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435014031 active site 479435014032 phosphorylation site [posttranslational modification] 479435014033 intermolecular recognition site; other site 479435014034 dimerization interface [polypeptide binding]; other site 479435014035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435014036 DNA binding residues [nucleotide binding] 479435014037 dimerization interface [polypeptide binding]; other site 479435014038 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435014039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014040 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 479435014041 MPT binding site; other site 479435014042 trimer interface [polypeptide binding]; other site 479435014043 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 479435014044 trimer interface [polypeptide binding]; other site 479435014045 dimer interface [polypeptide binding]; other site 479435014046 putative active site [active] 479435014047 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479435014048 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435014049 dimer interface [polypeptide binding]; other site 479435014050 putative functional site; other site 479435014051 putative MPT binding site; other site 479435014052 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435014053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014054 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 479435014055 active site 479435014056 substrate binding site [chemical binding]; other site 479435014057 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 479435014058 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435014059 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 479435014060 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 479435014061 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 479435014062 active site 479435014063 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 479435014064 SAF domain; Region: SAF; cl00555 479435014065 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 479435014066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014067 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435014068 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435014069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435014071 META domain; Region: META; cl01245 479435014072 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435014073 putative sugar binding sites [chemical binding]; other site 479435014074 Q-X-W motif; other site 479435014075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435014076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435014077 active site 479435014078 phosphorylation site [posttranslational modification] 479435014079 intermolecular recognition site; other site 479435014080 dimerization interface [polypeptide binding]; other site 479435014081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435014082 DNA binding site [nucleotide binding] 479435014083 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 479435014084 sensor protein RstB; Provisional; Region: PRK10604 479435014085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 479435014086 YCII-related domain; Region: YCII; cl00999 479435014087 SEC-C motif; Region: SEC-C; cl12132 479435014088 hypothetical protein; Provisional; Region: PRK04233 479435014089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014090 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435014091 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435014092 active site 479435014093 metal binding site [ion binding]; metal-binding site 479435014094 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435014095 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435014096 conserved cys residue [active] 479435014097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435014098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435014099 GAF domain; Region: GAF; cl00853 479435014100 ANTAR domain; Region: ANTAR; cl04297 479435014101 ANTAR domain; Region: ANTAR; cl04297 479435014102 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479435014103 ANTAR domain; Region: ANTAR; cl04297 479435014104 FOG: CBS domain [General function prediction only]; Region: COG0517 479435014105 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 479435014106 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435014107 sugar binding site [chemical binding]; other site 479435014108 Domain of unknown function DUF11; Region: DUF11; cl15273 479435014109 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435014110 putative metal binding site [ion binding]; other site 479435014111 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435014112 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435014113 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435014114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435014115 S-adenosylmethionine binding site [chemical binding]; other site 479435014116 short chain dehydrogenase; Provisional; Region: PRK06197 479435014117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014118 NAD(P) binding site [chemical binding]; other site 479435014119 active site 479435014120 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 479435014121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014122 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014123 Predicted ATPase [General function prediction only]; Region: COG3899 479435014124 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435014125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435014126 DNA binding residues [nucleotide binding] 479435014127 dimerization interface [polypeptide binding]; other site 479435014128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014129 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 479435014130 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 479435014131 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 479435014132 substrate binding pocket [chemical binding]; other site 479435014133 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 479435014134 B12 binding site [chemical binding]; other site 479435014135 cobalt ligand [ion binding]; other site 479435014136 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 479435014137 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435014138 CRISPR-associated protein, TIGR03985 family; Region: TIGR03985 479435014139 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435014140 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435014141 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435014142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435014143 hypothetical protein; Provisional; Region: PRK06815 479435014144 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435014145 tetramer interface [polypeptide binding]; other site 479435014146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435014147 catalytic residue [active] 479435014148 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435014149 active site 479435014150 catalytic triad [active] 479435014151 oxyanion hole [active] 479435014152 glycyl-tRNA synthetase; Provisional; Region: PRK14908 479435014153 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 479435014154 dimer interface [polypeptide binding]; other site 479435014155 motif 1; other site 479435014156 active site 479435014157 motif 2; other site 479435014158 motif 3; other site 479435014159 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 479435014160 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 479435014161 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435014162 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435014163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014164 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435014165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435014167 YCII-related domain; Region: YCII; cl00999 479435014168 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479435014169 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435014170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014171 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435014172 Walker A/P-loop; other site 479435014173 ATP binding site [chemical binding]; other site 479435014174 Q-loop/lid; other site 479435014175 ABC transporter signature motif; other site 479435014176 Walker B; other site 479435014177 D-loop; other site 479435014178 H-loop/switch region; other site 479435014179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014180 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435014182 classical (c) SDRs; Region: SDR_c; cd05233 479435014183 NAD(P) binding site [chemical binding]; other site 479435014184 active site 479435014185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435014186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435014187 DNA-binding site [nucleotide binding]; DNA binding site 479435014188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014189 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014191 hypothetical protein; Provisional; Region: PRK07588 479435014192 TIGR03086 family protein; Region: TIGR03086 479435014193 uncharacterized HhH-GPD family protein; Region: TIGR03252 479435014194 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435014195 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435014196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 479435014197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435014198 ABC-ATPase subunit interface; other site 479435014199 dimer interface [polypeptide binding]; other site 479435014200 putative PBP binding regions; other site 479435014201 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 479435014202 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435014203 siderophore binding site; other site 479435014204 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435014205 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435014206 Walker A/P-loop; other site 479435014207 ATP binding site [chemical binding]; other site 479435014208 Q-loop/lid; other site 479435014209 ABC transporter signature motif; other site 479435014210 Walker B; other site 479435014211 D-loop; other site 479435014212 H-loop/switch region; other site 479435014213 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479435014214 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 479435014215 active site 479435014216 FMN binding site [chemical binding]; other site 479435014217 2,4-decadienoyl-CoA binding site; other site 479435014218 catalytic residue [active] 479435014219 4Fe-4S cluster binding site [ion binding]; other site 479435014220 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 479435014221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014223 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 479435014224 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 479435014225 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435014226 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479435014227 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435014228 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 479435014229 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435014230 DNA binding site [nucleotide binding] 479435014231 active site 479435014232 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435014233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014234 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 479435014235 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 479435014236 AlkA N-terminal domain; Region: AlkA_N; cl05528 479435014237 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479435014238 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435014239 minor groove reading motif; other site 479435014240 helix-hairpin-helix signature motif; other site 479435014241 substrate binding pocket [chemical binding]; other site 479435014242 active site 479435014243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435014244 classical (c) SDRs; Region: SDR_c; cd05233 479435014245 NAD(P) binding site [chemical binding]; other site 479435014246 active site 479435014247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435014248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014250 DNA binding site [nucleotide binding] 479435014251 domain linker motif; other site 479435014252 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 479435014253 ligand binding site [chemical binding]; other site 479435014254 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435014255 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435014256 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 479435014257 Walker A/P-loop; other site 479435014258 ATP binding site [chemical binding]; other site 479435014259 Q-loop/lid; other site 479435014260 ABC transporter signature motif; other site 479435014261 Walker B; other site 479435014262 D-loop; other site 479435014263 H-loop/switch region; other site 479435014264 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435014265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014266 Walker A/P-loop; other site 479435014267 ATP binding site [chemical binding]; other site 479435014268 Q-loop/lid; other site 479435014269 ABC transporter signature motif; other site 479435014270 Walker B; other site 479435014271 D-loop; other site 479435014272 H-loop/switch region; other site 479435014273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435014274 DNA-binding site [nucleotide binding]; DNA binding site 479435014275 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 479435014276 Aminotransferase class IV; Region: Aminotran_4; pfam01063 479435014277 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 479435014278 substrate-cofactor binding pocket; other site 479435014279 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 479435014280 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435014281 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435014282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435014283 S-adenosylmethionine binding site [chemical binding]; other site 479435014284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014285 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 479435014286 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 479435014287 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 479435014288 DNA photolyase; Region: DNA_photolyase; pfam00875 479435014289 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 479435014290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435014291 DNA-binding site [nucleotide binding]; DNA binding site 479435014292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435014293 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435014294 Walker A/P-loop; other site 479435014295 ATP binding site [chemical binding]; other site 479435014296 Q-loop/lid; other site 479435014297 ABC transporter signature motif; other site 479435014298 Walker B; other site 479435014299 D-loop; other site 479435014300 H-loop/switch region; other site 479435014301 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435014302 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 479435014303 intersubunit interface [polypeptide binding]; other site 479435014304 active site 479435014305 zinc binding site [ion binding]; other site 479435014306 Na+ binding site [ion binding]; other site 479435014307 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 479435014308 putative substrate binding site [chemical binding]; other site 479435014309 putative ATP binding site [chemical binding]; other site 479435014310 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 479435014311 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 479435014312 active site 479435014313 dimer interface [polypeptide binding]; other site 479435014314 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435014315 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435014316 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435014317 CoenzymeA binding site [chemical binding]; other site 479435014318 subunit interaction site [polypeptide binding]; other site 479435014319 PHB binding site; other site 479435014320 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479435014321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435014324 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435014325 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435014326 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435014327 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435014328 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 479435014329 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435014330 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 479435014331 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 479435014332 Citrate synthase; Region: Citrate_synt; pfam00285 479435014333 oxalacetate binding site [chemical binding]; other site 479435014334 citrylCoA binding site [chemical binding]; other site 479435014335 coenzyme A binding site [chemical binding]; other site 479435014336 catalytic triad [active] 479435014337 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435014338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435014339 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435014340 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 479435014341 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435014342 hydrophobic ligand binding site; other site 479435014343 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 479435014344 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435014345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435014346 catalytic residue [active] 479435014347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435014348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014349 dimerization interface [polypeptide binding]; other site 479435014350 putative DNA binding site [nucleotide binding]; other site 479435014351 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435014352 putative Zn2+ binding site [ion binding]; other site 479435014353 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014355 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 479435014356 trimer interface [polypeptide binding]; other site 479435014357 active site 479435014358 substrate binding site [chemical binding]; other site 479435014359 CoA binding site [chemical binding]; other site 479435014360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014362 DNA binding site [nucleotide binding] 479435014363 domain linker motif; other site 479435014364 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435014365 dimerization interface [polypeptide binding]; other site 479435014366 ligand binding site [chemical binding]; other site 479435014367 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435014368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435014369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435014370 dimer interface [polypeptide binding]; other site 479435014371 conserved gate region; other site 479435014372 putative PBP binding loops; other site 479435014373 ABC-ATPase subunit interface; other site 479435014374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435014375 dimer interface [polypeptide binding]; other site 479435014376 conserved gate region; other site 479435014377 putative PBP binding loops; other site 479435014378 ABC-ATPase subunit interface; other site 479435014379 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 479435014380 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 479435014381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014382 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435014383 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435014384 mycothione reductase; Reviewed; Region: PRK07846 479435014385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435014387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014388 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014389 putative substrate translocation pore; other site 479435014390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014391 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 479435014392 dimer interface [polypeptide binding]; other site 479435014393 ligand binding site [chemical binding]; other site 479435014394 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 479435014395 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435014396 Sulfate transporter family; Region: Sulfate_transp; cl00967 479435014397 Permease family; Region: Xan_ur_permease; pfam00860 479435014398 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 479435014399 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014400 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 479435014401 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 479435014402 DNA-binding site [nucleotide binding]; DNA binding site 479435014403 RNA-binding motif; other site 479435014404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435014405 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435014406 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 479435014407 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 479435014408 Ligand Binding Site [chemical binding]; other site 479435014409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014410 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 479435014411 active site 479435014412 diiron metal binding site [ion binding]; other site 479435014413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435014414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435014415 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435014416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014417 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435014418 dimerization interface [polypeptide binding]; other site 479435014419 substrate binding pocket [chemical binding]; other site 479435014420 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 479435014421 Restriction endonuclease; Region: Mrr_cat; cl00747 479435014422 Protein of unknown function (DUF541); Region: SIMPL; cl01077 479435014423 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 479435014424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435014425 active site 479435014426 metal binding site [ion binding]; metal-binding site 479435014427 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435014428 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014431 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435014432 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 479435014433 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435014434 nudix motif; other site 479435014435 DNA repair helicase rad25; Region: rad25; TIGR00603 479435014436 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 479435014437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435014439 nucleotide binding region [chemical binding]; other site 479435014440 ATP-binding site [chemical binding]; other site 479435014441 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 479435014442 Ligand binding site [chemical binding]; other site 479435014443 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479435014444 active site 479435014445 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435014446 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435014447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435014449 FOG: WD40-like repeat [Function unknown]; Region: COG1520 479435014450 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 479435014451 active site 479435014452 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435014453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014454 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 479435014455 elongation factor Tu; Reviewed; Region: PRK12736 479435014456 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 479435014457 G1 box; other site 479435014458 GEF interaction site [polypeptide binding]; other site 479435014459 GTP/Mg2+ binding site [chemical binding]; other site 479435014460 Switch I region; other site 479435014461 G2 box; other site 479435014462 G3 box; other site 479435014463 Switch II region; other site 479435014464 G4 box; other site 479435014465 G5 box; other site 479435014466 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 479435014467 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 479435014468 Antibiotic Binding Site [chemical binding]; other site 479435014469 CutC family; Region: CutC; cl01218 479435014470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014472 DNA binding site [nucleotide binding] 479435014473 domain linker motif; other site 479435014474 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435014475 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 479435014476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435014477 active site 479435014478 catalytic tetrad [active] 479435014479 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 479435014480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014481 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435014482 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435014483 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 479435014484 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435014485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435014486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435014487 active site 479435014488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014489 dimerization interface [polypeptide binding]; other site 479435014490 putative DNA binding site [nucleotide binding]; other site 479435014491 putative Zn2+ binding site [ion binding]; other site 479435014492 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 479435014493 putative hydrophobic ligand binding site [chemical binding]; other site 479435014494 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435014495 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435014496 putative catalytic site [active] 479435014497 putative metal binding site [ion binding]; other site 479435014498 putative phosphate binding site [ion binding]; other site 479435014499 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 479435014500 dimer interface [polypeptide binding]; other site 479435014501 putative active site [active] 479435014502 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 479435014503 dimerization interface [polypeptide binding]; other site 479435014504 active site 479435014505 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 479435014506 folate binding site [chemical binding]; other site 479435014507 NADP+ binding site [chemical binding]; other site 479435014508 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 479435014509 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435014510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435014511 Walker A motif; other site 479435014512 ATP binding site [chemical binding]; other site 479435014513 Walker B motif; other site 479435014514 arginine finger; other site 479435014515 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479435014516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 479435014517 substrate binding pocket [chemical binding]; other site 479435014518 membrane-bound complex binding site; other site 479435014519 hinge residues; other site 479435014520 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435014521 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435014522 active site 479435014523 ATP binding site [chemical binding]; other site 479435014524 substrate binding site [chemical binding]; other site 479435014525 activation loop (A-loop); other site 479435014526 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479435014527 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435014528 metal ion-dependent adhesion site (MIDAS); other site 479435014529 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435014530 phosphopeptide binding site; other site 479435014531 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435014532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014533 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cd06462 479435014534 Catalytic site [active] 479435014535 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014536 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435014537 Walker A/P-loop; other site 479435014538 ATP binding site [chemical binding]; other site 479435014539 Q-loop/lid; other site 479435014540 ABC transporter signature motif; other site 479435014541 Walker B; other site 479435014542 D-loop; other site 479435014543 H-loop/switch region; other site 479435014544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014545 DinB superfamily; Region: DinB_2; cl00986 479435014546 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479435014547 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479435014548 ring oligomerisation interface [polypeptide binding]; other site 479435014549 ATP/Mg binding site [chemical binding]; other site 479435014550 stacking interactions; other site 479435014551 hinge regions; other site 479435014552 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435014553 PspC domain; Region: PspC; cl00864 479435014554 Peptidase family M48; Region: Peptidase_M48; cl12018 479435014555 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435014556 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435014557 active site 479435014558 catalytic site [active] 479435014559 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435014560 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435014561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435014562 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435014563 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014564 Q-loop/lid; other site 479435014565 ABC transporter signature motif; other site 479435014566 Walker B; other site 479435014567 D-loop; other site 479435014568 H-loop/switch region; other site 479435014569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435014570 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435014571 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014572 Walker A/P-loop; other site 479435014573 ATP binding site [chemical binding]; other site 479435014574 Q-loop/lid; other site 479435014575 ABC transporter signature motif; other site 479435014576 Walker B; other site 479435014577 D-loop; other site 479435014578 H-loop/switch region; other site 479435014579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435014580 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 479435014581 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 479435014582 putative active site [active] 479435014583 putative metal binding site [ion binding]; other site 479435014584 methionine aminopeptidase; Reviewed; Region: PRK07281 479435014585 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435014586 active site 479435014587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435014588 FeS/SAM binding site; other site 479435014589 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435014590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014591 NAD(P) binding site [chemical binding]; other site 479435014592 active site 479435014593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014594 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014595 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435014596 putative catalytic site [active] 479435014597 putative metal binding site [ion binding]; other site 479435014598 putative phosphate binding site [ion binding]; other site 479435014599 HSP90 family protein; Provisional; Region: PRK14083 479435014600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435014601 ATP binding site [chemical binding]; other site 479435014602 Mg2+ binding site [ion binding]; other site 479435014603 G-X-G motif; other site 479435014604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014605 P-loop motif; other site 479435014606 ATP binding site [chemical binding]; other site 479435014607 Chloramphenicol (Cm) binding site [chemical binding]; other site 479435014608 catalytic residue [active] 479435014609 GMP synthase; Reviewed; Region: guaA; PRK00074 479435014610 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 479435014611 AMP/PPi binding site [chemical binding]; other site 479435014612 candidate oxyanion hole; other site 479435014613 catalytic triad [active] 479435014614 potential glutamine specificity residues [chemical binding]; other site 479435014615 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 479435014616 ATP Binding subdomain [chemical binding]; other site 479435014617 Ligand Binding sites [chemical binding]; other site 479435014618 Dimerization subdomain; other site 479435014619 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 479435014620 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 479435014621 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435014622 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435014623 catalytic residue [active] 479435014624 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 479435014625 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 479435014626 inhibitor-cofactor binding pocket; inhibition site 479435014627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435014628 catalytic residue [active] 479435014629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014630 biotin synthase; Validated; Region: PRK06256 479435014631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435014632 FeS/SAM binding site; other site 479435014633 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 479435014634 IPP transferase; Region: IPPT; cl00403 479435014635 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435014636 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435014637 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435014638 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 479435014639 NAD(P) binding site [chemical binding]; other site 479435014640 catalytic residues [active] 479435014641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435014643 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 479435014644 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 479435014645 active site 479435014646 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 479435014647 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435014648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 479435014649 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 479435014650 active site 479435014651 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 479435014652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435014654 DNA binding residues [nucleotide binding] 479435014655 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479435014656 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479435014657 ring oligomerisation interface [polypeptide binding]; other site 479435014658 ATP/Mg binding site [chemical binding]; other site 479435014659 stacking interactions; other site 479435014660 hinge regions; other site 479435014661 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 479435014662 oligomerisation interface [polypeptide binding]; other site 479435014663 mobile loop; other site 479435014664 roof hairpin; other site 479435014665 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435014666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435014667 S-adenosylmethionine binding site [chemical binding]; other site 479435014668 Phosphotransferase enzyme family; Region: APH; pfam01636 479435014669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435014670 active site 479435014671 ATP binding site [chemical binding]; other site 479435014672 substrate binding site [chemical binding]; other site 479435014673 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435014674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014675 UGMP family protein; Validated; Region: PRK09604 479435014676 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 479435014677 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 479435014678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435014679 Coenzyme A binding pocket [chemical binding]; other site 479435014680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435014681 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 479435014682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435014683 Coenzyme A binding pocket [chemical binding]; other site 479435014684 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 479435014685 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435014686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014687 alanine racemase; Reviewed; Region: alr; PRK00053 479435014688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 479435014689 active site 479435014690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435014691 dimer interface [polypeptide binding]; other site 479435014692 substrate binding site [chemical binding]; other site 479435014693 catalytic residues [active] 479435014694 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435014695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435014696 motif II; other site 479435014697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435014698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435014699 putative dimerization interface [polypeptide binding]; other site 479435014700 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435014701 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435014702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435014703 catalytic residue [active] 479435014704 META domain; Region: META; cl01245 479435014705 META domain; Region: META; cl01245 479435014706 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435014707 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 479435014708 putative ligand binding site [chemical binding]; other site 479435014709 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 479435014710 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 479435014711 putative substrate binding site [chemical binding]; other site 479435014712 putative ATP binding site [chemical binding]; other site 479435014713 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 479435014714 pantothenate kinase; Provisional; Region: PRK05439 479435014715 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 479435014716 ATP-binding site [chemical binding]; other site 479435014717 CoA-binding site [chemical binding]; other site 479435014718 Mg2+-binding site [ion binding]; other site 479435014719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435014720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435014721 homodimer interface [polypeptide binding]; other site 479435014722 catalytic residue [active] 479435014723 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435014724 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435014725 active site 479435014726 substrate binding site [chemical binding]; other site 479435014727 FMN binding site [chemical binding]; other site 479435014728 putative catalytic residues [active] 479435014729 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435014730 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435014731 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 479435014732 active site 479435014733 catalytic triad [active] 479435014734 oxyanion hole [active] 479435014735 acyl-CoA synthetase; Validated; Region: PRK06188 479435014736 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435014737 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014739 putative substrate translocation pore; other site 479435014740 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 479435014741 active site 479435014742 catalytic triad [active] 479435014743 oxyanion hole [active] 479435014744 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 479435014745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435014746 S-adenosylmethionine binding site [chemical binding]; other site 479435014747 Domain of unknown function (DUF407); Region: DUF407; pfam04174 479435014748 Domain of unknown function (DUF407); Region: DUF407; pfam04174 479435014749 Domain of unknown function (DUF407); Region: DUF407; pfam04174 479435014750 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435014751 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479435014752 alpha subunit interface [polypeptide binding]; other site 479435014753 TPP binding site [chemical binding]; other site 479435014754 heterodimer interface [polypeptide binding]; other site 479435014755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435014756 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435014757 tetramer interface [polypeptide binding]; other site 479435014758 TPP-binding site [chemical binding]; other site 479435014759 heterodimer interface [polypeptide binding]; other site 479435014760 phosphorylation loop region [posttranslational modification] 479435014761 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 479435014762 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435014763 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 479435014764 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479435014765 dimer interface [polypeptide binding]; other site 479435014766 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 479435014767 active site 479435014768 Fe binding site [ion binding]; other site 479435014769 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 479435014770 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435014771 dimer interface [polypeptide binding]; other site 479435014772 active site 479435014773 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435014774 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435014775 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435014776 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435014777 active site 479435014778 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435014779 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 479435014780 AMP-binding enzyme; Region: AMP-binding; pfam00501 479435014781 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435014782 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 479435014783 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 479435014784 putative active site [active] 479435014785 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435014786 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 479435014787 putative active site [active] 479435014788 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435014789 Beta-lactamase; Region: Beta-lactamase; cl01009 479435014790 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435014791 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 479435014792 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435014793 putative catalytic site [active] 479435014794 putative metal binding site [ion binding]; other site 479435014795 putative phosphate binding site [ion binding]; other site 479435014796 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435014797 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435014798 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435014799 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435014800 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435014801 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435014802 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435014803 putative catalytic site [active] 479435014804 putative metal binding site [ion binding]; other site 479435014805 putative phosphate binding site [ion binding]; other site 479435014806 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 479435014807 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 479435014808 active site 479435014809 substrate binding site [chemical binding]; other site 479435014810 metal binding site [ion binding]; metal-binding site 479435014811 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 479435014812 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 479435014813 23S rRNA interface [nucleotide binding]; other site 479435014814 L3 interface [polypeptide binding]; other site 479435014815 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 479435014816 Citrate synthase; Region: Citrate_synt; pfam00285 479435014817 oxalacetate binding site [chemical binding]; other site 479435014818 citrylCoA binding site [chemical binding]; other site 479435014819 coenzyme A binding site [chemical binding]; other site 479435014820 catalytic triad [active] 479435014821 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435014822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014823 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435014824 active site 479435014825 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435014826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435014827 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435014828 Walker A/P-loop; other site 479435014829 ATP binding site [chemical binding]; other site 479435014830 Q-loop/lid; other site 479435014831 ABC transporter signature motif; other site 479435014832 Walker B; other site 479435014833 D-loop; other site 479435014834 H-loop/switch region; other site 479435014835 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435014836 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435014837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435014839 DNA binding residues [nucleotide binding] 479435014840 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 479435014841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435014842 S-adenosylmethionine binding site [chemical binding]; other site 479435014843 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 479435014844 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 479435014845 dimerization interface 3.5A [polypeptide binding]; other site 479435014846 active site 479435014847 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 479435014848 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 479435014849 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 479435014850 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 479435014851 alphaNTD homodimer interface [polypeptide binding]; other site 479435014852 alphaNTD - beta interaction site [polypeptide binding]; other site 479435014853 alphaNTD - beta' interaction site [polypeptide binding]; other site 479435014854 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 479435014855 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 479435014856 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 479435014857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435014858 RNA binding surface [nucleotide binding]; other site 479435014859 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 479435014860 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 479435014861 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 479435014862 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 479435014863 rRNA binding site [nucleotide binding]; other site 479435014864 predicted 30S ribosome binding site; other site 479435014865 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435014866 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435014867 methionine aminopeptidase; Reviewed; Region: PRK07281 479435014868 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435014869 active site 479435014870 adenylate kinase; Reviewed; Region: adk; PRK00279 479435014871 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 479435014872 AMP-binding site [chemical binding]; other site 479435014873 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 479435014874 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 479435014875 SecY translocase; Region: SecY; pfam00344 479435014876 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 479435014877 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 479435014878 23S rRNA binding site [nucleotide binding]; other site 479435014879 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 479435014880 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 479435014881 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 479435014882 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 479435014883 5S rRNA interface [nucleotide binding]; other site 479435014884 L27 interface [polypeptide binding]; other site 479435014885 23S rRNA interface [nucleotide binding]; other site 479435014886 L5 interface [polypeptide binding]; other site 479435014887 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 479435014888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479435014889 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479435014890 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 479435014891 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 479435014892 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 479435014893 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 479435014894 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 479435014895 KOW motif; Region: KOW; cl00354 479435014896 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 479435014897 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 479435014898 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 479435014899 23S rRNA interface [nucleotide binding]; other site 479435014900 putative translocon interaction site; other site 479435014901 signal recognition particle (SRP54) interaction site; other site 479435014902 L23 interface [polypeptide binding]; other site 479435014903 trigger factor interaction site; other site 479435014904 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 479435014905 23S rRNA interface [nucleotide binding]; other site 479435014906 5S rRNA interface [nucleotide binding]; other site 479435014907 putative antibiotic binding site [chemical binding]; other site 479435014908 L25 interface [polypeptide binding]; other site 479435014909 L27 interface [polypeptide binding]; other site 479435014910 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 479435014911 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 479435014912 G-X-X-G motif; other site 479435014913 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 479435014914 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 479435014915 putative translocon binding site; other site 479435014916 protein-rRNA interface [nucleotide binding]; other site 479435014917 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 479435014918 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 479435014919 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 479435014920 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 479435014921 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 479435014922 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 479435014923 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 479435014924 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 479435014925 elongation factor Tu; Reviewed; Region: PRK00049 479435014926 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 479435014927 G1 box; other site 479435014928 GEF interaction site [polypeptide binding]; other site 479435014929 GTP/Mg2+ binding site [chemical binding]; other site 479435014930 Switch I region; other site 479435014931 G2 box; other site 479435014932 G3 box; other site 479435014933 Switch II region; other site 479435014934 G4 box; other site 479435014935 G5 box; other site 479435014936 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 479435014937 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 479435014938 Antibiotic Binding Site [chemical binding]; other site 479435014939 elongation factor G; Reviewed; Region: PRK00007 479435014940 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 479435014941 G1 box; other site 479435014942 putative GEF interaction site [polypeptide binding]; other site 479435014943 GTP/Mg2+ binding site [chemical binding]; other site 479435014944 Switch I region; other site 479435014945 G2 box; other site 479435014946 G3 box; other site 479435014947 Switch II region; other site 479435014948 G4 box; other site 479435014949 G5 box; other site 479435014950 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 479435014951 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 479435014952 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 479435014953 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 479435014954 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 479435014955 S17 interaction site [polypeptide binding]; other site 479435014956 S8 interaction site; other site 479435014957 16S rRNA interaction site [nucleotide binding]; other site 479435014958 streptomycin interaction site [chemical binding]; other site 479435014959 23S rRNA interaction site [nucleotide binding]; other site 479435014960 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 479435014961 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 479435014962 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 479435014963 DinB superfamily; Region: DinB_2; cl00986 479435014964 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435014965 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479435014966 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435014967 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435014968 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 479435014969 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 479435014970 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 479435014971 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 479435014972 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 479435014973 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 479435014974 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 479435014975 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 479435014976 G-loop; other site 479435014977 DNA binding site [nucleotide binding] 479435014978 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 479435014979 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 479435014980 RPB12 interaction site [polypeptide binding]; other site 479435014981 RPB1 interaction site [polypeptide binding]; other site 479435014982 RPB10 interaction site [polypeptide binding]; other site 479435014983 RPB11 interaction site [polypeptide binding]; other site 479435014984 RPB3 interaction site [polypeptide binding]; other site 479435014985 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435014986 mce related protein; Region: MCE; pfam02470 479435014987 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435014988 mce related protein; Region: MCE; pfam02470 479435014989 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435014990 mce related protein; Region: MCE; pfam02470 479435014991 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435014992 mce related protein; Region: MCE; pfam02470 479435014993 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435014994 mce related protein; Region: MCE; pfam02470 479435014995 mce related protein; Region: MCE; pfam02470 479435014996 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 479435014997 Domain of unknown function DUF140; Region: DUF140; cl00510 479435014998 Domain of unknown function DUF140; Region: DUF140; cl00510 479435014999 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 479435015000 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 479435015001 Walker A/P-loop; other site 479435015002 ATP binding site [chemical binding]; other site 479435015003 Q-loop/lid; other site 479435015004 ABC transporter signature motif; other site 479435015005 Walker B; other site 479435015006 D-loop; other site 479435015007 H-loop/switch region; other site 479435015008 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479435015009 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 479435015010 core dimer interface [polypeptide binding]; other site 479435015011 peripheral dimer interface [polypeptide binding]; other site 479435015012 L10 interface [polypeptide binding]; other site 479435015013 L11 interface [polypeptide binding]; other site 479435015014 putative EF-Tu interaction site [polypeptide binding]; other site 479435015015 putative EF-G interaction site [polypeptide binding]; other site 479435015016 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 479435015017 23S rRNA interface [nucleotide binding]; other site 479435015018 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 479435015019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435015020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015021 putative substrate translocation pore; other site 479435015022 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435015023 homotrimer interaction site [polypeptide binding]; other site 479435015024 putative active site [active] 479435015025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015026 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435015027 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435015028 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 479435015029 substrate binding site [chemical binding]; other site 479435015030 ATP binding site [chemical binding]; other site 479435015031 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 479435015032 active site 479435015033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435015034 dimer interface [polypeptide binding]; other site 479435015035 substrate binding site [chemical binding]; other site 479435015036 catalytic residue [active] 479435015037 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 479435015038 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 479435015039 active site 479435015040 putative substrate binding pocket [chemical binding]; other site 479435015041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435015042 Entner-Doudoroff aldolase; Region: eda; TIGR01182 479435015043 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435015044 active site 479435015045 intersubunit interface [polypeptide binding]; other site 479435015046 catalytic residue [active] 479435015047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435015048 motif 1; other site 479435015049 dimer interface [polypeptide binding]; other site 479435015050 active site 479435015051 motif 2; other site 479435015052 motif 3; other site 479435015053 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 479435015054 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435015055 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435015056 active site 479435015057 substrate binding site [chemical binding]; other site 479435015058 FMN binding site [chemical binding]; other site 479435015059 putative catalytic residues [active] 479435015060 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 479435015061 mRNA/rRNA interface [nucleotide binding]; other site 479435015062 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 479435015063 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 479435015064 23S rRNA interface [nucleotide binding]; other site 479435015065 L7/L12 interface [polypeptide binding]; other site 479435015066 putative thiostrepton binding site; other site 479435015067 L25 interface [polypeptide binding]; other site 479435015068 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 479435015069 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 479435015070 putative homodimer interface [polypeptide binding]; other site 479435015071 KOW motif; Region: KOW; cl00354 479435015072 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 479435015073 hypothetical protein; Validated; Region: PRK07682 479435015074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435015075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015076 homodimer interface [polypeptide binding]; other site 479435015077 catalytic residue [active] 479435015078 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435015079 active site 479435015080 catalytic triad [active] 479435015081 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 479435015082 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435015083 active site 479435015084 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479435015085 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479435015086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015087 catalytic residue [active] 479435015088 PhoD-like phosphatase; Region: PhoD; pfam09423 479435015089 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435015090 putative active site [active] 479435015091 putative metal binding site [ion binding]; other site 479435015092 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 479435015093 FAD binding domain; Region: FAD_binding_4; pfam01565 479435015094 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 479435015095 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 479435015096 active site 479435015097 catalytic site [active] 479435015098 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 479435015099 active site 479435015100 catalytic site [active] 479435015101 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435015102 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 479435015103 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435015104 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435015105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015106 Coenzyme A binding pocket [chemical binding]; other site 479435015107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435015108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435015110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435015111 non-specific DNA binding site [nucleotide binding]; other site 479435015112 salt bridge; other site 479435015113 sequence-specific DNA binding site [nucleotide binding]; other site 479435015114 Cupin domain; Region: Cupin_2; cl09118 479435015115 Integral membrane protein TerC family; Region: TerC; cl10468 479435015116 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 479435015117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435015118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435015119 DNA binding site [nucleotide binding] 479435015120 domain linker motif; other site 479435015121 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435015122 dimerization interface [polypeptide binding]; other site 479435015123 ligand binding site [chemical binding]; other site 479435015124 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 479435015125 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435015126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435015127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435015128 active site 479435015129 metal binding site [ion binding]; metal-binding site 479435015130 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435015131 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435015132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435015133 S-adenosylmethionine binding site [chemical binding]; other site 479435015134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015135 Active site [active] 479435015136 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 479435015137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435015138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435015139 active site 479435015140 catalytic tetrad [active] 479435015141 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435015142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435015143 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435015144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015146 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435015147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015148 putative substrate translocation pore; other site 479435015149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015151 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 479435015152 Protein of unknown function (DUF520); Region: DUF520; cl00723 479435015153 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015154 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435015155 active site 479435015156 ATP binding site [chemical binding]; other site 479435015157 substrate binding site [chemical binding]; other site 479435015158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435015159 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 479435015160 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 479435015161 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435015162 active site 479435015163 NTP binding site [chemical binding]; other site 479435015164 metal binding triad [ion binding]; metal-binding site 479435015165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015166 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 479435015167 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015168 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 479435015169 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015171 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 479435015172 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 479435015173 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 479435015174 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 479435015175 4Fe-4S binding domain; Region: Fer4; cl02805 479435015176 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246 479435015177 FAD binding site [chemical binding]; other site 479435015178 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435015179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435015181 YCII-related domain; Region: YCII; cl00999 479435015182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435015183 dimer interface [polypeptide binding]; other site 479435015184 phosphorylation site [posttranslational modification] 479435015185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435015186 ATP binding site [chemical binding]; other site 479435015187 Mg2+ binding site [ion binding]; other site 479435015188 G-X-G motif; other site 479435015189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435015190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435015191 active site 479435015192 phosphorylation site [posttranslational modification] 479435015193 intermolecular recognition site; other site 479435015194 dimerization interface [polypeptide binding]; other site 479435015195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435015196 DNA binding site [nucleotide binding] 479435015197 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 479435015198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435015199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435015200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435015201 Walker A/P-loop; other site 479435015202 ATP binding site [chemical binding]; other site 479435015203 Q-loop/lid; other site 479435015204 ABC transporter signature motif; other site 479435015205 Walker B; other site 479435015206 D-loop; other site 479435015207 H-loop/switch region; other site 479435015208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435015209 FtsX-like permease family; Region: FtsX; pfam02687 479435015210 NADH dehydrogenase; Region: NADHdh; cl00469 479435015211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015212 NAD(P) binding site [chemical binding]; other site 479435015213 active site 479435015214 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 479435015215 putative active site [active] 479435015216 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 479435015217 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 479435015218 Sodium:solute symporter family; Region: SSF; cl00456 479435015219 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435015220 Isochorismatase family; Region: Isochorismatase; pfam00857 479435015221 catalytic triad [active] 479435015222 conserved cis-peptide bond; other site 479435015223 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435015224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435015225 DNA-binding site [nucleotide binding]; DNA binding site 479435015226 UTRA domain; Region: UTRA; cl01230 479435015227 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435015228 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 479435015229 substrate binding site [chemical binding]; other site 479435015230 ATP binding site [chemical binding]; other site 479435015231 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 479435015232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435015233 dimerization interface [polypeptide binding]; other site 479435015234 DNA binding residues [nucleotide binding] 479435015235 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 479435015236 active site 479435015237 dimer interface [polypeptide binding]; other site 479435015238 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 479435015239 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 479435015240 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 479435015241 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 479435015242 dimer interface [polypeptide binding]; other site 479435015243 PYR/PP interface [polypeptide binding]; other site 479435015244 TPP binding site [chemical binding]; other site 479435015245 substrate binding site [chemical binding]; other site 479435015246 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 479435015247 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 479435015248 TPP-binding site [chemical binding]; other site 479435015249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015250 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435015251 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 479435015252 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 479435015253 oligomeric interface; other site 479435015254 putative active site [active] 479435015255 homodimer interface [polypeptide binding]; other site 479435015256 Phd_YefM; Region: PhdYeFM; cl09153 479435015257 Protein of unknown function (DUF445); Region: DUF445; pfam04286 479435015258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435015260 putative substrate translocation pore; other site 479435015261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015262 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 479435015263 homotrimer interaction site [polypeptide binding]; other site 479435015264 putative active site [active] 479435015265 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435015266 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 479435015267 phosphate binding site [ion binding]; other site 479435015268 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479435015269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435015270 motif II; other site 479435015271 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435015272 Peptidase M15; Region: Peptidase_M15_3; cl01194 479435015273 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435015274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435015276 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435015277 Predicted permeases [General function prediction only]; Region: RarD; COG2962 479435015278 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435015279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435015280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015281 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 479435015282 Cupin domain; Region: Cupin_2; cl09118 479435015283 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435015284 hydrophobic ligand binding site; other site 479435015285 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015286 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435015287 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435015288 substrate binding pocket [chemical binding]; other site 479435015289 chain length determination region; other site 479435015290 substrate-Mg2+ binding site; other site 479435015291 catalytic residues [active] 479435015292 aspartate-rich region 1; other site 479435015293 active site lid residues [active] 479435015294 aspartate-rich region 2; other site 479435015295 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 479435015296 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015297 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 479435015298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015299 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 479435015300 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 479435015301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 479435015302 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 479435015303 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 479435015304 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 479435015305 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 479435015306 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 479435015307 4Fe-4S binding domain; Region: Fer4; cl02805 479435015308 4Fe-4S binding domain; Region: Fer4; cl02805 479435015309 NADH dehydrogenase; Region: NADHdh; cl00469 479435015310 NADH dehydrogenase subunit G; Validated; Region: PRK07860 479435015311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435015312 catalytic loop [active] 479435015313 iron binding site [ion binding]; other site 479435015314 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 479435015315 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 479435015316 molybdopterin cofactor binding site; other site 479435015317 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 479435015318 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 479435015319 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 479435015320 SLBB domain; Region: SLBB; pfam10531 479435015321 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 479435015322 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 479435015323 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 479435015324 putative dimer interface [polypeptide binding]; other site 479435015325 [2Fe-2S] cluster binding site [ion binding]; other site 479435015326 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 479435015327 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 479435015328 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 479435015329 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 479435015330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015331 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479435015332 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 479435015333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435015334 S-adenosylmethionine binding site [chemical binding]; other site 479435015335 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 479435015336 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435015337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435015338 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 479435015339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015340 Predicted acetyltransferase [General function prediction only]; Region: COG3393 479435015341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015344 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435015345 Walker A/P-loop; other site 479435015346 ATP binding site [chemical binding]; other site 479435015347 Q-loop/lid; other site 479435015348 ABC transporter signature motif; other site 479435015349 Walker B; other site 479435015350 D-loop; other site 479435015351 H-loop/switch region; other site 479435015352 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435015353 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 479435015354 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 479435015355 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 479435015356 dimer interface [polypeptide binding]; other site 479435015357 tetramer interface [polypeptide binding]; other site 479435015358 PYR/PP interface [polypeptide binding]; other site 479435015359 TPP binding site [chemical binding]; other site 479435015360 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 479435015361 TPP-binding site; other site 479435015362 O-succinylbenzoate synthase; Provisional; Region: PRK02901 479435015363 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 479435015364 active site 479435015365 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435015366 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 479435015367 UbiA prenyltransferase family; Region: UbiA; cl00337 479435015368 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479435015369 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 479435015370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435015371 catalytic residue [active] 479435015372 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435015373 Peptidase family M48; Region: Peptidase_M48; cl12018 479435015374 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 479435015375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015376 Coenzyme A binding pocket [chemical binding]; other site 479435015377 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 479435015378 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 479435015379 active site 479435015380 catalytic triad [active] 479435015381 oxyanion hole [active] 479435015382 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435015383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015384 putative substrate translocation pore; other site 479435015385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015386 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 479435015387 ResB-like family; Region: ResB; pfam05140 479435015388 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 479435015389 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 479435015390 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 479435015391 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 479435015392 catalytic residues [active] 479435015393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435015394 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435015395 catalytic core [active] 479435015396 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 479435015397 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 479435015398 inhibitor-cofactor binding pocket; inhibition site 479435015399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015400 catalytic residue [active] 479435015401 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435015402 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 479435015403 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435015404 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435015405 active site 479435015406 catalytic triad [active] 479435015407 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 479435015408 PA/protease or protease-like domain interface [polypeptide binding]; other site 479435015409 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435015410 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435015411 acyl-CoA synthetase; Validated; Region: PRK09192 479435015412 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435015413 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435015414 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 479435015415 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479435015416 active site 479435015417 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479435015418 Acyl transferase domain; Region: Acyl_transf_1; cl08282 479435015419 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435015420 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435015421 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435015422 Condensation domain; Region: Condensation; cl09290 479435015423 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435015424 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435015425 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435015426 Condensation domain; Region: Condensation; cl09290 479435015427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435015428 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435015429 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 479435015430 Calx-beta domain; Region: Calx-beta; cl02522 479435015431 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435015432 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435015433 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435015434 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435015435 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435015436 conserved cys residue [active] 479435015437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435015438 Isochorismatase family; Region: Isochorismatase; pfam00857 479435015439 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 479435015440 catalytic triad [active] 479435015441 conserved cis-peptide bond; other site 479435015442 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 479435015443 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 479435015444 active site 479435015445 catalytic residues [active] 479435015446 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435015447 conserved cys residue [active] 479435015448 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435015449 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435015450 conserved cys residue [active] 479435015451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015452 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435015453 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435015454 NADP binding site [chemical binding]; other site 479435015455 homodimer interface [polypeptide binding]; other site 479435015456 active site 479435015457 substrate binding site [chemical binding]; other site 479435015458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015460 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435015461 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435015462 DNA binding residues [nucleotide binding] 479435015463 putative dimer interface [polypeptide binding]; other site 479435015464 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435015465 Cytochrome P450; Region: p450; cl12078 479435015466 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435015467 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015468 active site 479435015469 ATP binding site [chemical binding]; other site 479435015470 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435015471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435015473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435015474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435015475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435015476 dimer interface [polypeptide binding]; other site 479435015477 conserved gate region; other site 479435015478 putative PBP binding loops; other site 479435015479 ABC-ATPase subunit interface; other site 479435015480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435015481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435015482 putative PBP binding loops; other site 479435015483 dimer interface [polypeptide binding]; other site 479435015484 ABC-ATPase subunit interface; other site 479435015485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435015486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435015487 DNA binding site [nucleotide binding] 479435015488 domain linker motif; other site 479435015489 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435015490 ligand binding site [chemical binding]; other site 479435015491 dimerization interface [polypeptide binding]; other site 479435015492 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 479435015493 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435015494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435015495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435015496 dimer interface [polypeptide binding]; other site 479435015497 conserved gate region; other site 479435015498 putative PBP binding loops; other site 479435015499 ABC-ATPase subunit interface; other site 479435015500 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435015501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435015502 dimer interface [polypeptide binding]; other site 479435015503 conserved gate region; other site 479435015504 putative PBP binding loops; other site 479435015505 ABC-ATPase subunit interface; other site 479435015506 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435015507 anti sigma factor interaction site; other site 479435015508 regulatory phosphorylation site [posttranslational modification]; other site 479435015509 GAF domain; Region: GAF; cl00853 479435015510 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 479435015511 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435015512 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 479435015513 B12 binding site [chemical binding]; other site 479435015514 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435015515 NADP+ binding site [chemical binding]; other site 479435015516 folate binding site [chemical binding]; other site 479435015517 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435015518 enterobactin exporter EntS; Provisional; Region: PRK10489 479435015519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015520 putative substrate translocation pore; other site 479435015521 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 479435015522 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 479435015523 dimer interface [polypeptide binding]; other site 479435015524 active site 479435015525 Schiff base residues; other site 479435015526 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 479435015527 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 479435015528 active site 479435015529 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 479435015530 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 479435015531 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 479435015532 domain interfaces; other site 479435015533 active site 479435015534 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 479435015535 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 479435015536 tRNA; other site 479435015537 putative tRNA binding site [nucleotide binding]; other site 479435015538 putative NADP binding site [chemical binding]; other site 479435015539 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 479435015540 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 479435015541 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 479435015542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015543 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 479435015544 catalytic residues [active] 479435015545 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 479435015546 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435015547 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435015548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435015550 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435015551 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 479435015552 putative acyl-acceptor binding pocket; other site 479435015553 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435015554 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 479435015555 putative NAD(P) binding site [chemical binding]; other site 479435015556 active site 479435015557 putative substrate binding site [chemical binding]; other site 479435015558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435015559 S-adenosylmethionine binding site [chemical binding]; other site 479435015560 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435015561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015563 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479435015564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435015565 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435015566 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 479435015567 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 479435015568 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 479435015569 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479435015570 active site 479435015571 HIGH motif; other site 479435015572 dimer interface [polypeptide binding]; other site 479435015573 KMSKS motif; other site 479435015574 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 479435015575 putative catalytic site [active] 479435015576 putative metal binding site [ion binding]; other site 479435015577 putative phosphate binding site [ion binding]; other site 479435015578 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435015579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435015580 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 479435015581 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 479435015582 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 479435015583 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 479435015584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435015585 motif II; other site 479435015586 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 479435015587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015588 Proline dehydrogenase; Region: Pro_dh; cl03282 479435015589 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435015590 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435015591 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 479435015592 Walker A/P-loop; other site 479435015593 ATP binding site [chemical binding]; other site 479435015594 Q-loop/lid; other site 479435015595 ABC transporter signature motif; other site 479435015596 Walker B; other site 479435015597 D-loop; other site 479435015598 H-loop/switch region; other site 479435015599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015601 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 479435015602 AP (apurinic/apyrimidinic) site pocket; other site 479435015603 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435015604 Metal-binding active site; metal-binding site 479435015605 exopolyphosphatase; Region: exo_poly_only; TIGR03706 479435015606 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 479435015607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015608 NAD(P) binding site [chemical binding]; other site 479435015609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435015610 active site 479435015611 Condensation domain; Region: Condensation; cl09290 479435015612 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479435015613 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563 479435015614 active site 479435015615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015616 putative substrate translocation pore; other site 479435015617 Predicted acetyltransferase [General function prediction only]; Region: COG3393 479435015618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435015621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435015622 S-adenosylmethionine binding site [chemical binding]; other site 479435015623 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435015624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435015625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435015626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435015627 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 479435015628 DNA repair protein RadA; Provisional; Region: PRK11823 479435015629 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 479435015630 Walker A motif/ATP binding site; other site 479435015631 ATP binding site [chemical binding]; other site 479435015632 Walker B motif; other site 479435015633 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479435015634 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435015635 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 479435015636 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 479435015637 dimer interface [polypeptide binding]; other site 479435015638 active site 479435015639 CoA binding pocket [chemical binding]; other site 479435015640 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 479435015641 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 479435015642 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 479435015643 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435015644 endonuclease III; Region: ENDO3c; smart00478 479435015645 minor groove reading motif; other site 479435015646 helix-hairpin-helix signature motif; other site 479435015647 substrate binding pocket [chemical binding]; other site 479435015648 active site 479435015649 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 479435015650 major vault protein; Provisional; Region: PTZ00491 479435015651 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435015652 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435015653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435015655 DNA binding residues [nucleotide binding] 479435015656 Clp protease ATP binding subunit; Region: clpC; CHL00095 479435015657 Clp amino terminal domain; Region: Clp_N; pfam02861 479435015658 Clp amino terminal domain; Region: Clp_N; pfam02861 479435015659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435015660 Walker A motif; other site 479435015661 ATP binding site [chemical binding]; other site 479435015662 Walker B motif; other site 479435015663 arginine finger; other site 479435015664 UvrB/uvrC motif; Region: UVR; pfam02151 479435015665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435015666 Walker A motif; other site 479435015667 ATP binding site [chemical binding]; other site 479435015668 Walker B motif; other site 479435015669 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 479435015670 Lsr2; Region: Lsr2; pfam11774 479435015671 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 479435015672 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 479435015673 dimer interface [polypeptide binding]; other site 479435015674 putative anticodon binding site; other site 479435015675 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435015676 motif 1; other site 479435015677 dimer interface [polypeptide binding]; other site 479435015678 active site 479435015679 motif 2; other site 479435015680 motif 3; other site 479435015681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015682 putative substrate translocation pore; other site 479435015683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435015684 dimerization interface [polypeptide binding]; other site 479435015685 putative DNA binding site [nucleotide binding]; other site 479435015686 putative Zn2+ binding site [ion binding]; other site 479435015687 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435015688 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 479435015689 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 479435015690 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 479435015691 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 479435015692 dimerization interface [polypeptide binding]; other site 479435015693 active site 479435015694 L-aspartate oxidase; Provisional; Region: PRK07804 479435015695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015696 domain; Region: Succ_DH_flav_C; pfam02910 479435015697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435015698 active site 479435015699 KMSKS motif; other site 479435015700 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 479435015701 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 479435015702 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 479435015703 Predicted membrane protein [Function unknown]; Region: COG3428 479435015704 Bacterial membrane flanked domain; Region: DUF304; cl01348 479435015705 Bacterial membrane flanked domain; Region: DUF304; cl01348 479435015706 Bacterial membrane flanked domain; Region: DUF304; cl01348 479435015707 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 479435015708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435015709 HipA-like N-terminal domain; Region: HipA_N; pfam07805 479435015710 HipA-like C-terminal domain; Region: HipA_C; pfam07804 479435015711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435015712 S-adenosylmethionine binding site [chemical binding]; other site 479435015713 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435015714 active site 479435015715 dimerization interface [polypeptide binding]; other site 479435015716 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 479435015717 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 479435015718 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 479435015719 catalytic center binding site [active] 479435015720 ATP binding site [chemical binding]; other site 479435015721 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 479435015722 homooctamer interface [polypeptide binding]; other site 479435015723 active site 479435015724 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435015725 dihydropteroate synthase; Region: DHPS; TIGR01496 479435015726 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 479435015727 substrate binding pocket [chemical binding]; other site 479435015728 dimer interface [polypeptide binding]; other site 479435015729 inhibitor binding site; inhibition site 479435015730 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 479435015731 homodecamer interface [polypeptide binding]; other site 479435015732 GTP cyclohydrolase I; Provisional; Region: PLN03044 479435015733 active site 479435015734 putative catalytic site residues [active] 479435015735 zinc binding site [ion binding]; other site 479435015736 GTP-CH-I/GFRP interaction surface; other site 479435015737 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 479435015738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435015739 Walker A motif; other site 479435015740 ATP binding site [chemical binding]; other site 479435015741 Walker B motif; other site 479435015742 arginine finger; other site 479435015743 Peptidase family M41; Region: Peptidase_M41; pfam01434 479435015744 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435015745 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 479435015746 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 479435015747 PBP4 family; Region: PBP4; TIGR00666 479435015748 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 479435015749 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 479435015750 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 479435015751 dimer interface [polypeptide binding]; other site 479435015752 substrate binding site [chemical binding]; other site 479435015753 metal binding sites [ion binding]; metal-binding site 479435015754 NlpC/P60 family; Region: NLPC_P60; cl11438 479435015755 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435015756 putative catalytic site [active] 479435015757 putative metal binding site [ion binding]; other site 479435015758 putative phosphate binding site [ion binding]; other site 479435015759 Ycf48-like protein; Provisional; Region: PRK13684 479435015760 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 479435015761 bile acid transporter; Region: bass; TIGR00841 479435015762 Membrane transport protein; Region: Mem_trans; cl09117 479435015763 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 479435015764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015765 NAD(P) binding site [chemical binding]; other site 479435015766 active site 479435015767 Domain of unknown function DUF77; Region: DUF77; cl00307 479435015768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435015770 putative substrate translocation pore; other site 479435015771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015772 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435015773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015774 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435015775 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435015776 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435015777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435015779 DNA binding residues [nucleotide binding] 479435015780 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435015781 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 479435015782 FO synthase; Reviewed; Region: fbiC; PRK09234 479435015783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435015784 FeS/SAM binding site; other site 479435015785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 479435015786 FeS/SAM binding site; other site 479435015787 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 479435015788 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435015789 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435015790 active site 479435015791 metal binding site [ion binding]; metal-binding site 479435015792 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479435015793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435015794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435015795 active site 479435015796 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479435015797 DNA binding residues [nucleotide binding] 479435015798 TOBE domain; Region: TOBE_2; cl01440 479435015799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435015800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435015801 dimer interface [polypeptide binding]; other site 479435015802 conserved gate region; other site 479435015803 putative PBP binding loops; other site 479435015804 ABC-ATPase subunit interface; other site 479435015805 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 479435015806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015807 Walker A/P-loop; other site 479435015808 ATP binding site [chemical binding]; other site 479435015809 Q-loop/lid; other site 479435015810 ABC transporter signature motif; other site 479435015811 Walker B; other site 479435015812 D-loop; other site 479435015813 H-loop/switch region; other site 479435015814 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 479435015815 heme binding pocket [chemical binding]; other site 479435015816 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435015817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435015818 active site 479435015819 ATP binding site [chemical binding]; other site 479435015820 substrate binding site [chemical binding]; other site 479435015821 activation loop (A-loop); other site 479435015822 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 479435015823 active site 479435015824 zinc binding site [ion binding]; other site 479435015825 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435015826 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435015827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435015828 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 479435015829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015830 Walker A/P-loop; other site 479435015831 ATP binding site [chemical binding]; other site 479435015832 Q-loop/lid; other site 479435015833 ABC transporter signature motif; other site 479435015834 Walker B; other site 479435015835 D-loop; other site 479435015836 H-loop/switch region; other site 479435015837 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435015838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015839 Walker A/P-loop; other site 479435015840 ATP binding site [chemical binding]; other site 479435015841 Q-loop/lid; other site 479435015842 ABC transporter signature motif; other site 479435015843 Walker B; other site 479435015844 D-loop; other site 479435015845 H-loop/switch region; other site 479435015846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435015848 DNA binding residues [nucleotide binding] 479435015849 dimerization interface [polypeptide binding]; other site 479435015850 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 479435015851 putative peptidoglycan binding site; other site 479435015852 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 479435015853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435015854 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 479435015855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435015856 Active site [active] 479435015857 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 479435015858 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 479435015859 putative [Fe4-S4] binding site [ion binding]; other site 479435015860 putative molybdopterin cofactor binding site [chemical binding]; other site 479435015861 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 479435015862 molybdopterin cofactor binding site; other site 479435015863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435015864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435015865 DNA binding site [nucleotide binding] 479435015866 domain linker motif; other site 479435015867 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435015868 dimerization interface [polypeptide binding]; other site 479435015869 ligand binding site [chemical binding]; other site 479435015870 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435015871 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435015872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015873 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 479435015874 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435015875 DNA binding residues [nucleotide binding] 479435015876 dimer interface [polypeptide binding]; other site 479435015877 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 479435015878 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 479435015879 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 479435015880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015881 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435015882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435015883 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 479435015884 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 479435015885 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 479435015886 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435015887 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 479435015888 tetramerization interface [polypeptide binding]; other site 479435015889 NAD(P) binding site [chemical binding]; other site 479435015890 catalytic residues [active] 479435015891 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435015892 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435015893 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 479435015894 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 479435015895 active site 479435015896 zinc binding site [ion binding]; other site 479435015897 Predicted ATPase [General function prediction only]; Region: COG3899 479435015898 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015901 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435015902 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 479435015903 TspO/MBR family; Region: TspO_MBR; cl01379 479435015904 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 479435015905 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 479435015906 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 479435015907 dimer interface [polypeptide binding]; other site 479435015908 putative anticodon binding site; other site 479435015909 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435015910 motif 1; other site 479435015911 dimer interface [polypeptide binding]; other site 479435015912 active site 479435015913 motif 2; other site 479435015914 motif 3; other site 479435015915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435015916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435015917 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 479435015918 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 479435015919 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 479435015920 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 479435015921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435015922 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 479435015923 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435015924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435015925 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435015926 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 479435015927 proline aminopeptidase P II; Provisional; Region: PRK10879 479435015928 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 479435015929 active site 479435015930 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435015931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435015932 DNA-binding site [nucleotide binding]; DNA binding site 479435015933 FCD domain; Region: FCD; cl11656 479435015934 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 479435015935 LamB/YcsF family; Region: LamB_YcsF; cl00664 479435015936 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 479435015937 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 479435015938 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 479435015939 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 479435015940 Proline racemase; Region: Pro_racemase; pfam05544 479435015941 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435015942 inhibitor site; inhibition site 479435015943 active site 479435015944 dimer interface [polypeptide binding]; other site 479435015945 catalytic residue [active] 479435015946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435015947 A subunit; Region: glycerol3P_GlpA; TIGR03377 479435015948 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 479435015949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435015950 non-specific DNA binding site [nucleotide binding]; other site 479435015951 salt bridge; other site 479435015952 sequence-specific DNA binding site [nucleotide binding]; other site 479435015953 Cupin domain; Region: Cupin_2; cl09118 479435015954 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 479435015955 NAD(P) binding site [chemical binding]; other site 479435015956 active site 479435015957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435015959 dimerization interface [polypeptide binding]; other site 479435015960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015961 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 479435015962 cleavage site 479435015963 active site 479435015964 substrate binding sites [chemical binding]; other site 479435015965 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435015966 active site 479435015967 catalytic site [active] 479435015968 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479435015969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015970 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435015971 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435015972 E3 interaction surface; other site 479435015973 lipoyl attachment site [posttranslational modification]; other site 479435015974 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 479435015975 e3 binding domain; Region: E3_binding; pfam02817 479435015976 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 479435015977 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435015978 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479435015979 alpha subunit interface [polypeptide binding]; other site 479435015980 TPP binding site [chemical binding]; other site 479435015981 heterodimer interface [polypeptide binding]; other site 479435015982 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435015983 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479435015984 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435015985 tetramer interface [polypeptide binding]; other site 479435015986 TPP-binding site [chemical binding]; other site 479435015987 heterodimer interface [polypeptide binding]; other site 479435015988 phosphorylation loop region [posttranslational modification] 479435015989 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 479435015990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435015991 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 479435015992 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 479435015993 catalytic residue [active] 479435015994 putative FPP diphosphate binding site; other site 479435015995 putative FPP binding hydrophobic cleft; other site 479435015996 dimer interface [polypeptide binding]; other site 479435015997 putative IPP diphosphate binding site; other site 479435015998 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435015999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016000 Coenzyme A binding pocket [chemical binding]; other site 479435016001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435016002 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435016003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016004 DinB superfamily; Region: DinB_2; cl00986 479435016005 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479435016006 dimer interface [polypeptide binding]; other site 479435016007 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435016008 active site 479435016009 metal binding site [ion binding]; metal-binding site 479435016010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 479435016011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016012 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435016013 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 479435016014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435016017 classical (c) SDRs; Region: SDR_c; cd05233 479435016018 NAD(P) binding site [chemical binding]; other site 479435016019 active site 479435016020 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435016021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016022 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435016023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435016024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 479435016025 S-adenosylmethionine binding site [chemical binding]; other site 479435016026 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 479435016027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016028 DNA-binding site [nucleotide binding]; DNA binding site 479435016029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016030 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435016031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016034 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 479435016035 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 479435016036 Mg++ binding site [ion binding]; other site 479435016037 putative catalytic motif [active] 479435016038 putative substrate binding site [chemical binding]; other site 479435016039 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 479435016040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016042 active site 479435016043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016045 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435016046 FtsX-like permease family; Region: FtsX; pfam02687 479435016047 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435016048 FtsX-like permease family; Region: FtsX; pfam02687 479435016049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435016050 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435016051 Walker A/P-loop; other site 479435016052 ATP binding site [chemical binding]; other site 479435016053 Q-loop/lid; other site 479435016054 ABC transporter signature motif; other site 479435016055 Walker B; other site 479435016056 D-loop; other site 479435016057 H-loop/switch region; other site 479435016058 Histidine kinase; Region: HisKA_3; pfam07730 479435016059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435016060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435016061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435016062 active site 479435016063 phosphorylation site [posttranslational modification] 479435016064 intermolecular recognition site; other site 479435016065 dimerization interface [polypeptide binding]; other site 479435016066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435016067 DNA binding residues [nucleotide binding] 479435016068 dimerization interface [polypeptide binding]; other site 479435016069 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435016070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435016071 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 479435016072 putative sugar binding sites [chemical binding]; other site 479435016073 Q-X-W motif; other site 479435016074 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435016075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435016076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016077 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435016078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016079 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435016080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016081 NAD(P) binding site [chemical binding]; other site 479435016082 active site 479435016083 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 479435016084 active site 479435016085 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 479435016086 hypothetical protein; Reviewed; Region: PRK09588 479435016087 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 479435016088 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016089 FAD binding domain; Region: FAD_binding_4; pfam01565 479435016090 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479435016091 Dehydratase family; Region: ILVD_EDD; cl00340 479435016092 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 479435016093 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 479435016094 dimer interface [polypeptide binding]; other site 479435016095 NADP binding site [chemical binding]; other site 479435016096 catalytic residues [active] 479435016097 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479435016098 galactarate dehydratase; Region: galactar-dH20; TIGR03248 479435016099 SAF domain; Region: SAF; cl00555 479435016100 SAF domain; Region: SAF; cl00555 479435016101 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435016102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016103 DNA-binding site [nucleotide binding]; DNA binding site 479435016104 FCD domain; Region: FCD; cl11656 479435016105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 479435016106 putative substrate translocation pore; other site 479435016107 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479435016108 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 479435016109 FMN binding site [chemical binding]; other site 479435016110 active site 479435016111 substrate binding site [chemical binding]; other site 479435016112 catalytic residue [active] 479435016113 Predicted ATPase [General function prediction only]; Region: COG3899 479435016114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435016115 DNA binding residues [nucleotide binding] 479435016116 dimerization interface [polypeptide binding]; other site 479435016117 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 479435016118 Peptidase family M48; Region: Peptidase_M48; cl12018 479435016119 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435016120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016121 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435016122 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435016123 active site 479435016124 catalytic site [active] 479435016125 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479435016126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016127 NAD+ binding site [chemical binding]; other site 479435016128 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479435016129 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 479435016130 putative N- and C-terminal domain interface [polypeptide binding]; other site 479435016131 putative active site [active] 479435016132 putative MgATP binding site [chemical binding]; other site 479435016133 putative xylulose binding site [chemical binding]; other site 479435016134 metal binding site [ion binding]; metal-binding site 479435016135 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435016136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016137 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 479435016138 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435016139 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435016140 catalytic core [active] 479435016141 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 479435016142 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 479435016143 N- and C-terminal domain interface [polypeptide binding]; other site 479435016144 active site 479435016145 MgATP binding site [chemical binding]; other site 479435016146 catalytic site [active] 479435016147 metal binding site [ion binding]; metal-binding site 479435016148 carbohydrate binding site [chemical binding]; other site 479435016149 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 479435016150 active site 479435016151 nucleophile elbow; other site 479435016152 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 479435016153 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 479435016154 active site 479435016155 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435016156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016157 dimer interface [polypeptide binding]; other site 479435016158 conserved gate region; other site 479435016159 putative PBP binding loops; other site 479435016160 ABC-ATPase subunit interface; other site 479435016161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016162 dimer interface [polypeptide binding]; other site 479435016163 conserved gate region; other site 479435016164 putative PBP binding loops; other site 479435016165 ABC-ATPase subunit interface; other site 479435016166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435016167 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 479435016168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435016169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435016170 active site 479435016171 ATP binding site [chemical binding]; other site 479435016172 substrate binding site [chemical binding]; other site 479435016173 activation loop (A-loop); other site 479435016174 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435016175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 479435016176 DNA binding residues [nucleotide binding] 479435016177 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 479435016178 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 479435016179 DAK2 domain; Region: Dak2; cl03685 479435016180 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 479435016181 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 479435016182 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 479435016183 dimerization domain swap beta strand [polypeptide binding]; other site 479435016184 regulatory protein interface [polypeptide binding]; other site 479435016185 active site 479435016186 regulatory phosphorylation site [posttranslational modification]; other site 479435016187 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 479435016188 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 479435016189 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 479435016190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016191 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435016192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435016193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435016194 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435016195 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 479435016196 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 479435016197 dimerization interface [polypeptide binding]; other site 479435016198 ATP binding site [chemical binding]; other site 479435016199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 479435016200 dimerization interface [polypeptide binding]; other site 479435016201 ATP binding site [chemical binding]; other site 479435016202 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435016203 conserved cys residue [active] 479435016204 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 479435016205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435016207 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435016208 Walker A/P-loop; other site 479435016209 ATP binding site [chemical binding]; other site 479435016210 Q-loop/lid; other site 479435016211 ABC transporter signature motif; other site 479435016212 Walker B; other site 479435016213 D-loop; other site 479435016214 H-loop/switch region; other site 479435016215 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435016216 OsmC-like protein; Region: OsmC; cl00767 479435016217 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 479435016218 ATP binding site [chemical binding]; other site 479435016219 active site 479435016220 substrate binding site [chemical binding]; other site 479435016221 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 479435016222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 479435016224 Cupin domain; Region: Cupin_2; cl09118 479435016225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435016226 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435016227 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435016228 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 479435016229 adenylosuccinate lyase; Region: purB; TIGR00928 479435016230 tetramer interface [polypeptide binding]; other site 479435016231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016232 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435016233 PhoD-like phosphatase; Region: PhoD; pfam09423 479435016234 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435016235 putative active site [active] 479435016236 putative metal binding site [ion binding]; other site 479435016237 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435016238 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 479435016239 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 479435016240 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435016241 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 479435016242 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435016243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016244 putative PBP binding loops; other site 479435016245 ABC-ATPase subunit interface; other site 479435016246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435016247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016248 dimer interface [polypeptide binding]; other site 479435016249 conserved gate region; other site 479435016250 putative PBP binding loops; other site 479435016251 ABC-ATPase subunit interface; other site 479435016252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435016253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435016254 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 479435016255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435016256 ATP binding site [chemical binding]; other site 479435016257 putative Mg++ binding site [ion binding]; other site 479435016258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435016259 nucleotide binding region [chemical binding]; other site 479435016260 ATP-binding site [chemical binding]; other site 479435016261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016262 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 479435016263 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435016264 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435016265 Walker A/P-loop; other site 479435016266 ATP binding site [chemical binding]; other site 479435016267 Q-loop/lid; other site 479435016268 ABC transporter signature motif; other site 479435016269 Walker B; other site 479435016270 D-loop; other site 479435016271 H-loop/switch region; other site 479435016272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435016273 ABC-ATPase subunit interface; other site 479435016274 dimer interface [polypeptide binding]; other site 479435016275 putative PBP binding regions; other site 479435016276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 479435016277 ABC-ATPase subunit interface; other site 479435016278 dimer interface [polypeptide binding]; other site 479435016279 putative PBP binding regions; other site 479435016280 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435016281 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435016282 FAD binding pocket [chemical binding]; other site 479435016283 FAD binding motif [chemical binding]; other site 479435016284 phosphate binding motif [ion binding]; other site 479435016285 NAD binding pocket [chemical binding]; other site 479435016286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435016289 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 479435016290 conserved cys residue [active] 479435016291 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435016292 active site 479435016293 ATP binding site [chemical binding]; other site 479435016294 substrate binding site [chemical binding]; other site 479435016295 activation loop (A-loop); other site 479435016296 adenylosuccinate synthetase; Provisional; Region: PRK01117 479435016297 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 479435016298 GDP-binding site [chemical binding]; other site 479435016299 ACT binding site; other site 479435016300 IMP binding site; other site 479435016301 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435016302 putative dimer interface [polypeptide binding]; other site 479435016303 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435016304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435016305 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 479435016306 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 479435016307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 479435016308 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 479435016309 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 479435016310 active site 479435016311 intersubunit interface [polypeptide binding]; other site 479435016312 zinc binding site [ion binding]; other site 479435016313 Na+ binding site [ion binding]; other site 479435016314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016315 DNA-binding site [nucleotide binding]; DNA binding site 479435016316 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435016317 UTRA domain; Region: UTRA; cl01230 479435016318 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 479435016319 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435016320 dimer interface [polypeptide binding]; other site 479435016321 active site 479435016322 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 479435016323 dimer interface [polypeptide binding]; other site 479435016324 active site 479435016325 trehalose synthase; Region: treS_nterm; TIGR02456 479435016326 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 479435016327 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 479435016328 Cupin domain; Region: Cupin_2; cl09118 479435016329 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 479435016330 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 479435016331 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435016332 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435016333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016334 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 479435016335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016336 LemA family; Region: LemA; cl00742 479435016337 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 479435016338 Cytotoxic; Region: Cytotoxic; pfam09000 479435016339 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435016340 active site 479435016341 catalytic site [active] 479435016342 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 479435016343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435016344 NAD(P) binding site [chemical binding]; other site 479435016345 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 479435016346 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 479435016347 substrate-cofactor binding pocket; other site 479435016348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016349 catalytic residue [active] 479435016350 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435016351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 479435016352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435016353 active site 479435016354 catalytic tetrad [active] 479435016355 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435016356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016357 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435016358 dimerization interface [polypeptide binding]; other site 479435016359 substrate binding pocket [chemical binding]; other site 479435016360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016361 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435016362 putative dimerization interface [polypeptide binding]; other site 479435016363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435016364 non-specific DNA binding site [nucleotide binding]; other site 479435016365 salt bridge; other site 479435016366 sequence-specific DNA binding site [nucleotide binding]; other site 479435016367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 479435016369 binding surface 479435016370 TPR motif; other site 479435016371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016372 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435016373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016374 NAD(P) binding site [chemical binding]; other site 479435016375 active site 479435016376 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435016377 putative catalytic site [active] 479435016378 putative metal binding site [ion binding]; other site 479435016379 putative phosphate binding site [ion binding]; other site 479435016380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016381 NAD(P) binding site [chemical binding]; other site 479435016382 active site 479435016383 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479435016384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435016385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435016386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016387 dimer interface [polypeptide binding]; other site 479435016388 conserved gate region; other site 479435016389 putative PBP binding loops; other site 479435016390 ABC-ATPase subunit interface; other site 479435016391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016392 dimer interface [polypeptide binding]; other site 479435016393 conserved gate region; other site 479435016394 putative PBP binding loops; other site 479435016395 ABC-ATPase subunit interface; other site 479435016396 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435016397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435016398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016399 DNA-binding site [nucleotide binding]; DNA binding site 479435016400 FCD domain; Region: FCD; cl11656 479435016401 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 479435016402 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435016403 putative metal binding site [ion binding]; other site 479435016404 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435016405 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435016406 homotrimer interaction site [polypeptide binding]; other site 479435016407 putative active site [active] 479435016408 hypothetical protein; Provisional; Region: PRK08912 479435016409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435016410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016411 homodimer interface [polypeptide binding]; other site 479435016412 catalytic residue [active] 479435016413 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 479435016414 Clp amino terminal domain; Region: Clp_N; pfam02861 479435016415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435016416 Walker A motif; other site 479435016417 ATP binding site [chemical binding]; other site 479435016418 Walker B motif; other site 479435016419 arginine finger; other site 479435016420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435016421 Walker A motif; other site 479435016422 ATP binding site [chemical binding]; other site 479435016423 Walker B motif; other site 479435016424 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 479435016425 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435016426 active site 479435016427 catalytic residues [active] 479435016428 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435016429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016430 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 479435016431 DNA binding residues [nucleotide binding] 479435016432 putative dimer interface [polypeptide binding]; other site 479435016433 chaperone protein DnaJ; Provisional; Region: PRK14295 479435016434 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 479435016435 HSP70 interaction site [polypeptide binding]; other site 479435016436 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 479435016437 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 479435016438 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 479435016439 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 479435016440 dimer interface [polypeptide binding]; other site 479435016441 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 479435016442 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 479435016443 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 479435016444 ATP binding site [chemical binding]; other site 479435016445 profilin binding site; other site 479435016446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016447 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435016448 Asp-box motif; other site 479435016449 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479435016450 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435016451 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 479435016452 active site 479435016453 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 479435016454 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016455 active site 479435016456 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 479435016457 allantoate amidohydrolase; Reviewed; Region: PRK09290 479435016458 active site 479435016459 metal binding site [ion binding]; metal-binding site 479435016460 dimer interface [polypeptide binding]; other site 479435016461 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 479435016462 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 479435016463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435016464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435016465 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 479435016466 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 479435016467 Walker A/P-loop; other site 479435016468 ATP binding site [chemical binding]; other site 479435016469 Q-loop/lid; other site 479435016470 ABC transporter signature motif; other site 479435016471 Walker B; other site 479435016472 D-loop; other site 479435016473 H-loop/switch region; other site 479435016474 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 479435016475 urocanate hydratase; Provisional; Region: PRK05414 479435016476 urocanate hydratase; Region: hutU; TIGR01228 479435016477 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435016478 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 479435016479 active sites [active] 479435016480 tetramer interface [polypeptide binding]; other site 479435016481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016482 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435016483 Coenzyme A binding pocket [chemical binding]; other site 479435016484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016485 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435016486 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435016487 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 479435016488 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 479435016489 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 479435016490 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 479435016491 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 479435016492 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 479435016493 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435016494 active sites [active] 479435016495 tetramer interface [polypeptide binding]; other site 479435016496 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 479435016497 active site 479435016498 catalytic triad [active] 479435016499 oxyanion hole [active] 479435016500 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 479435016501 active site 479435016502 catalytic triad [active] 479435016503 oxyanion hole [active] 479435016504 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 479435016505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435016506 active site 479435016507 phosphorylation site [posttranslational modification] 479435016508 intermolecular recognition site; other site 479435016509 dimerization interface [polypeptide binding]; other site 479435016510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435016511 DNA binding site [nucleotide binding] 479435016512 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 479435016513 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 479435016514 Ligand Binding Site [chemical binding]; other site 479435016515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435016516 dimer interface [polypeptide binding]; other site 479435016517 phosphorylation site [posttranslational modification] 479435016518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435016519 ATP binding site [chemical binding]; other site 479435016520 Mg2+ binding site [ion binding]; other site 479435016521 G-X-G motif; other site 479435016522 K+-transporting ATPase, c chain; Region: KdpC; cl00944 479435016523 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 479435016524 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435016525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 479435016526 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 479435016527 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 479435016528 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435016529 homotrimer interaction site [polypeptide binding]; other site 479435016530 putative active site [active] 479435016531 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479435016532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435016533 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 479435016534 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 479435016535 putative active site [active] 479435016536 putative substrate binding site [chemical binding]; other site 479435016537 ATP binding site [chemical binding]; other site 479435016538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435016539 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435016540 Active site [active] 479435016541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435016542 active site 479435016543 ATP binding site [chemical binding]; other site 479435016544 substrate binding site [chemical binding]; other site 479435016545 activation loop (A-loop); other site 479435016546 Cysteine dioxygenase type I; Region: CDO_I; cl02350 479435016547 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016548 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435016549 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435016550 DNA binding site [nucleotide binding] 479435016551 domain linker motif; other site 479435016552 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435016553 dimerization interface [polypeptide binding]; other site 479435016554 ligand binding site [chemical binding]; other site 479435016555 GAF domain; Region: GAF; cl00853 479435016556 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 479435016557 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435016558 NAD(P) binding site [chemical binding]; other site 479435016559 catalytic residues [active] 479435016560 Protein of unknown function (DUF779); Region: DUF779; cl01432 479435016561 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 479435016562 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435016563 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 479435016564 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 479435016565 Zn binding site [ion binding]; other site 479435016566 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435016567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016568 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479435016569 Cysteine-rich domain; Region: CCG; pfam02754 479435016570 Cysteine-rich domain; Region: CCG; pfam02754 479435016571 PhoD-like phosphatase; Region: PhoD; pfam09423 479435016572 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435016573 putative active site [active] 479435016574 putative metal binding site [ion binding]; other site 479435016575 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435016576 Predicted membrane protein [Function unknown]; Region: COG1470 479435016577 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435016578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435016579 classical (c) SDRs; Region: SDR_c; cd05233 479435016580 NAD(P) binding site [chemical binding]; other site 479435016581 active site 479435016582 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 479435016583 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 479435016584 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 479435016585 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 479435016586 trimer interface [polypeptide binding]; other site 479435016587 active site 479435016588 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435016589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016590 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cl03513 479435016591 substrate binding site [chemical binding]; other site 479435016592 catalytic residues [active] 479435016593 G5 domain; Region: G5; pfam07501 479435016594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016595 Coenzyme A binding pocket [chemical binding]; other site 479435016596 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435016597 DNA binding residues [nucleotide binding] 479435016598 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 479435016599 beta-clamp/clamp loader binding surface; other site 479435016600 beta-clamp/translesion DNA polymerase binding surface; other site 479435016601 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 479435016602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016603 metabolite-proton symporter; Region: 2A0106; TIGR00883 479435016604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016605 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 479435016606 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 479435016607 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 479435016608 FAD binding site [chemical binding]; other site 479435016609 substrate binding site [chemical binding]; other site 479435016610 catalytic residues [active] 479435016611 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 479435016612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016613 Uncharacterized conserved protein [Function unknown]; Region: COG3595 479435016614 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 479435016615 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435016616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 479435016617 dimer interface [polypeptide binding]; other site 479435016618 conserved gate region; other site 479435016619 putative PBP binding loops; other site 479435016620 ABC-ATPase subunit interface; other site 479435016621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 479435016622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435016623 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 479435016624 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435016625 catalytic Zn binding site [ion binding]; other site 479435016626 NAD(P) binding site [chemical binding]; other site 479435016627 structural Zn binding site [ion binding]; other site 479435016628 Flavin Reductases; Region: FlaRed; cl00801 479435016629 Beta-lactamase; Region: Beta-lactamase; cl01009 479435016630 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435016631 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435016632 NAD(P) binding site [chemical binding]; other site 479435016633 catalytic residues [active] 479435016634 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435016635 CoenzymeA binding site [chemical binding]; other site 479435016636 subunit interaction site [polypeptide binding]; other site 479435016637 PHB binding site; other site 479435016638 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 479435016639 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435016640 dimer interface [polypeptide binding]; other site 479435016641 active site 479435016642 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 479435016643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016645 DinB superfamily; Region: DinB_2; cl00986 479435016646 Protein of unknown function (DUF433); Region: DUF433; cl01030 479435016647 Beta-lactamase; Region: Beta-lactamase; cl01009 479435016648 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479435016649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016652 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435016653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016654 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435016655 Walker A/P-loop; other site 479435016656 ATP binding site [chemical binding]; other site 479435016657 Q-loop/lid; other site 479435016658 ABC transporter signature motif; other site 479435016659 Walker B; other site 479435016660 D-loop; other site 479435016661 H-loop/switch region; other site 479435016662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016663 putative substrate translocation pore; other site 479435016664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435016665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435016666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016667 DNA-binding site [nucleotide binding]; DNA binding site 479435016668 FCD domain; Region: FCD; cl11656 479435016669 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 479435016670 putative active site [active] 479435016671 catalytic triad [active] 479435016672 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479435016673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435016674 E3 interaction surface; other site 479435016675 lipoyl attachment site [posttranslational modification]; other site 479435016676 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 479435016677 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479435016678 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435016679 TPP-binding site [chemical binding]; other site 479435016680 tetramer interface [polypeptide binding]; other site 479435016681 heterodimer interface [polypeptide binding]; other site 479435016682 phosphorylation loop region [posttranslational modification] 479435016683 Phytase; Region: Phytase; pfam02333 479435016684 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 479435016685 EamA-like transporter family; Region: EamA; cl01037 479435016686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016687 NAD(P) binding site [chemical binding]; other site 479435016688 active site 479435016689 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 479435016690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435016691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016692 homodimer interface [polypeptide binding]; other site 479435016693 catalytic residue [active] 479435016694 Amidinotransferase; Region: Amidinotransf; cl12043 479435016695 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 479435016696 PEGA domain; Region: PEGA; pfam08308 479435016697 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435016698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016699 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 479435016700 DNA-binding site [nucleotide binding]; DNA binding site 479435016701 FCD domain; Region: FCD; cl11656 479435016702 Membrane protein of unknown function; Region: DUF360; cl00850 479435016703 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479435016704 Active site [active] 479435016705 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 479435016706 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 479435016707 active site 479435016708 ADP/pyrophosphate binding site [chemical binding]; other site 479435016709 dimerization interface [polypeptide binding]; other site 479435016710 allosteric effector site; other site 479435016711 fructose-1,6-bisphosphate binding site; other site 479435016712 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 479435016713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016714 EamA-like transporter family; Region: EamA; cl01037 479435016715 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 479435016716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435016717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435016718 active site 479435016719 phosphorylation site [posttranslational modification] 479435016720 intermolecular recognition site; other site 479435016721 dimerization interface [polypeptide binding]; other site 479435016722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435016723 DNA binding site [nucleotide binding] 479435016724 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 479435016725 dimerization interface [polypeptide binding]; other site 479435016726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435016727 dimer interface [polypeptide binding]; other site 479435016728 phosphorylation site [posttranslational modification] 479435016729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435016730 ATP binding site [chemical binding]; other site 479435016731 Mg2+ binding site [ion binding]; other site 479435016732 G-X-G motif; other site 479435016733 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 479435016734 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 479435016735 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 479435016736 protein binding site [polypeptide binding]; other site 479435016737 DinB superfamily; Region: DinB_2; cl00986 479435016738 Pirin-related protein [General function prediction only]; Region: COG1741 479435016739 Cupin domain; Region: Cupin_2; cl09118 479435016740 Domain of unknown function (DUF718); Region: DUF718; cl01281 479435016741 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435016742 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435016743 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 479435016744 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435016745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435016746 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 479435016747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 479435016748 Walker A motif; other site 479435016749 ATP binding site [chemical binding]; other site 479435016750 Walker B motif; other site 479435016751 arginine finger; other site 479435016752 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435016753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 479435016754 Transcription factor WhiB; Region: Whib; pfam02467 479435016755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 479435016756 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435016757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435016758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016759 Coenzyme A binding pocket [chemical binding]; other site 479435016760 DNA polymerase IV; Validated; Region: PRK03352 479435016761 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435016762 active site 479435016763 DNA binding site [nucleotide binding] 479435016764 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 479435016765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016766 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479435016767 ligand binding site [chemical binding]; other site 479435016768 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435016769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016770 DNA-binding site [nucleotide binding]; DNA binding site 479435016771 FCD domain; Region: FCD; cl11656 479435016772 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479435016773 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435016774 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 479435016775 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 479435016776 LysE type translocator; Region: LysE; cl00565 479435016777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016778 putative substrate translocation pore; other site 479435016779 helicase 45; Provisional; Region: PTZ00424 479435016780 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 479435016781 ATP binding site [chemical binding]; other site 479435016782 Mg++ binding site [ion binding]; other site 479435016783 motif III; other site 479435016784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435016785 nucleotide binding region [chemical binding]; other site 479435016786 ATP-binding site [chemical binding]; other site 479435016787 DinB superfamily; Region: DinB_2; cl00986 479435016788 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435016789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 479435016790 active site 479435016791 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435016792 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435016793 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435016794 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 479435016795 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 479435016796 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435016797 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 479435016798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435016800 dimerization interface [polypeptide binding]; other site 479435016801 LysE type translocator; Region: LysE; cl00565 479435016802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435016803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016804 NAD(P) binding site [chemical binding]; other site 479435016805 active site 479435016806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016807 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435016808 EamA-like transporter family; Region: EamA; cl01037 479435016809 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435016810 EamA-like transporter family; Region: EamA; cl01037 479435016811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435016813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016814 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 479435016815 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 479435016816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435016817 catalytic residue [active] 479435016818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435016819 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435016820 oligomer interface [polypeptide binding]; other site 479435016821 active site residues [active] 479435016822 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 479435016823 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435016824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435016825 catalytic residue [active] 479435016826 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435016827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016828 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435016829 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435016830 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 479435016831 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435016832 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435016833 UvrD/REP helicase; Region: UvrD-helicase; cl14126 479435016834 PHP domain; Region: PHP; pfam02811 479435016835 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435016836 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435016837 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435016839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435016840 active site 479435016841 phosphorylation site [posttranslational modification] 479435016842 intermolecular recognition site; other site 479435016843 dimerization interface [polypeptide binding]; other site 479435016844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435016845 dimerization interface [polypeptide binding]; other site 479435016846 DNA binding residues [nucleotide binding] 479435016847 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435016848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016849 DNA-binding site [nucleotide binding]; DNA binding site 479435016850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435016851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016852 homodimer interface [polypeptide binding]; other site 479435016853 catalytic residue [active] 479435016854 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435016855 FAD binding domain; Region: FAD_binding_4; pfam01565 479435016856 Berberine and berberine like; Region: BBE; pfam08031 479435016857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435016858 active site 479435016859 metal binding site [ion binding]; metal-binding site 479435016860 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 479435016861 nudix motif; other site 479435016862 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435016863 active site 479435016864 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 479435016865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016867 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435016868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435016869 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479435016870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435016871 classical (c) SDRs; Region: SDR_c; cd05233 479435016872 NAD(P) binding site [chemical binding]; other site 479435016873 active site 479435016874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435016877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016878 Walker A/P-loop; other site 479435016879 ATP binding site [chemical binding]; other site 479435016880 Q-loop/lid; other site 479435016881 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435016882 ABC transporter signature motif; other site 479435016883 Walker B; other site 479435016884 D-loop; other site 479435016885 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 479435016886 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 479435016887 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 479435016888 UbiA prenyltransferase family; Region: UbiA; cl00337 479435016889 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 479435016890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016891 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 479435016892 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 479435016893 putative active site [active] 479435016894 catalytic site [active] 479435016895 putative metal binding site [ion binding]; other site 479435016896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016897 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435016898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016899 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435016900 Walker A/P-loop; other site 479435016901 ATP binding site [chemical binding]; other site 479435016902 Q-loop/lid; other site 479435016903 ABC transporter signature motif; other site 479435016904 Walker B; other site 479435016905 D-loop; other site 479435016906 H-loop/switch region; other site 479435016907 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 479435016908 metal binding site [ion binding]; metal-binding site 479435016909 ABC-2 type transporter; Region: ABC2_membrane; cl11417 479435016910 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 479435016911 Erythromycin esterase; Region: Erythro_esteras; pfam05139 479435016912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016914 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016915 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 479435016916 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 479435016917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016918 NmrA-like family; Region: NmrA; pfam05368 479435016919 NAD(P) binding site [chemical binding]; other site 479435016920 active site 479435016921 Cupin domain; Region: Cupin_2; cl09118 479435016922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435016923 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435016924 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 479435016925 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479435016926 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 479435016927 Walker A/P-loop; other site 479435016928 ATP binding site [chemical binding]; other site 479435016929 Q-loop/lid; other site 479435016930 ABC transporter signature motif; other site 479435016931 Walker B; other site 479435016932 D-loop; other site 479435016933 H-loop/switch region; other site 479435016934 TOBE domain; Region: TOBE_2; cl01440 479435016935 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 479435016936 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435016937 homotrimer interaction site [polypeptide binding]; other site 479435016938 putative active site [active] 479435016939 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435016940 FAD binding domain; Region: FAD_binding_4; pfam01565 479435016941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016942 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435016943 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435016944 DNA binding residues [nucleotide binding] 479435016945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435016946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435016947 active site 479435016948 phosphorylation site [posttranslational modification] 479435016949 intermolecular recognition site; other site 479435016950 dimerization interface [polypeptide binding]; other site 479435016951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 479435016952 DNA binding residues [nucleotide binding] 479435016953 dimerization interface [polypeptide binding]; other site 479435016954 Histidine kinase; Region: HisKA_3; pfam07730 479435016955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435016956 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 479435016957 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 479435016958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016959 Walker A motif; other site 479435016960 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 479435016961 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 479435016962 Walker B motif; other site 479435016963 DNA binding loops [nucleotide binding] 479435016964 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 479435016965 thioester formation/cholesterol transfer; other site 479435016966 protein-splicing catalytic site; other site 479435016967 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 479435016968 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 479435016969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016970 MatE; Region: MatE; cl10513 479435016971 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 479435016972 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 479435016973 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479435016974 active site 479435016975 HIGH motif; other site 479435016976 dimer interface [polypeptide binding]; other site 479435016977 KMSKS motif; other site 479435016978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 479435016979 Walker A motif; other site 479435016980 ATP binding site [chemical binding]; other site 479435016981 Walker B motif; other site 479435016982 AAA-like domain; Region: AAA_10; pfam12846 479435016983 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 479435016984 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 479435016985 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 479435016986 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 479435016987 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479435016988 dimer interface [polypeptide binding]; other site 479435016989 ssDNA binding site [nucleotide binding]; other site 479435016990 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435016991 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 479435016992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435016993 putative DNA binding site [nucleotide binding]; other site 479435016994 putative Zn2+ binding site [ion binding]; other site 479435016995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435016996 endonuclease IV; Provisional; Region: PRK01060 479435016997 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 479435016998 AP (apurinic/apyrimidinic) site pocket; other site 479435016999 DNA interaction; other site 479435017000 Metal-binding active site; metal-binding site 479435017001 Beta-lactamase; Region: Beta-lactamase; cl01009 479435017002 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435017003 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435017004 classical (c) SDRs; Region: SDR_c; cd05233 479435017005 NAD(P) binding site [chemical binding]; other site 479435017006 active site 479435017007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017009 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 479435017010 FemAB family; Region: FemAB; cl11444 479435017011 FemAB family; Region: FemAB; cl11444 479435017012 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 479435017013 hypothetical protein; Provisional; Region: PRK08317 479435017014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435017015 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 479435017016 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 479435017017 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; cl02342 479435017018 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 479435017019 Transglycosylase; Region: Transgly; cl07896 479435017020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 479435017021 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 479435017022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435017023 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 479435017024 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 479435017025 Protein of unknown function DUF72; Region: DUF72; cl00777 479435017026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435017027 NAD(P) binding site [chemical binding]; other site 479435017028 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 479435017029 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 479435017030 active site 479435017031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435017032 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435017033 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 479435017034 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 479435017035 homodimer interface [polypeptide binding]; other site 479435017036 putative substrate binding pocket [chemical binding]; other site 479435017037 diiron center [ion binding]; other site 479435017038 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435017039 DNA binding residues [nucleotide binding] 479435017040 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435017041 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435017042 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435017043 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 479435017044 Walker A/P-loop; other site 479435017045 ATP binding site [chemical binding]; other site 479435017046 Q-loop/lid; other site 479435017047 ABC transporter signature motif; other site 479435017048 Walker B; other site 479435017049 D-loop; other site 479435017050 H-loop/switch region; other site 479435017051 HlyD family secretion protein; Region: HlyD_2; pfam12700 479435017052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435017053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 479435017054 active site 479435017055 phosphorylation site [posttranslational modification] 479435017056 intermolecular recognition site; other site 479435017057 dimerization interface [polypeptide binding]; other site 479435017058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 479435017059 DNA binding site [nucleotide binding] 479435017060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435017061 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 479435017062 dimerization interface [polypeptide binding]; other site 479435017063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 479435017064 dimer interface [polypeptide binding]; other site 479435017065 phosphorylation site [posttranslational modification] 479435017066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435017067 ATP binding site [chemical binding]; other site 479435017068 Mg2+ binding site [ion binding]; other site 479435017069 G-X-G motif; other site 479435017070 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 479435017071 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435017072 short chain dehydrogenase; Provisional; Region: PRK08251 479435017073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435017074 NAD(P) binding site [chemical binding]; other site 479435017075 active site 479435017076 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435017077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435017078 catalytic core [active] 479435017079 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 479435017080 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 479435017081 putative active site [active] 479435017082 putative substrate binding site [chemical binding]; other site 479435017083 ATP binding site [chemical binding]; other site 479435017084 short chain dehydrogenase; Provisional; Region: PRK05650 479435017085 classical (c) SDRs; Region: SDR_c; cd05233 479435017086 NAD(P) binding site [chemical binding]; other site 479435017087 active site 479435017088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435017089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435017090 active site 479435017091 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435017092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435017094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435017095 DNA binding site [nucleotide binding] 479435017096 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435017097 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 479435017098 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 479435017099 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435017100 sugar binding site [chemical binding]; other site 479435017101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435017102 active site 479435017103 metal binding site [ion binding]; metal-binding site 479435017104 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479435017105 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 479435017106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435017107 Coenzyme A binding pocket [chemical binding]; other site 479435017108 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 479435017109 homodimer interface [polypeptide binding]; other site 479435017110 substrate-cofactor binding pocket; other site 479435017111 Aminotransferase class IV; Region: Aminotran_4; pfam01063 479435017112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435017113 catalytic residue [active] 479435017114 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 479435017115 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 479435017116 active site 479435017117 NTP binding site [chemical binding]; other site 479435017118 metal binding triad [ion binding]; metal-binding site 479435017119 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 479435017120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435017121 Zn2+ binding site [ion binding]; other site 479435017122 Mg2+ binding site [ion binding]; other site 479435017123 integral membrane protein MviN; Region: mviN; TIGR01695 479435017124 Protein kinase domain; Region: Pkinase; pfam00069 479435017125 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435017126 active site 479435017127 ATP binding site [chemical binding]; other site 479435017128 substrate binding site [chemical binding]; other site 479435017129 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435017130 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 479435017132 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479435017133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435017134 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435017135 catalytic residues [active] 479435017136 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435017137 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435017138 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 479435017139 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 479435017140 active site 479435017141 metal binding site [ion binding]; metal-binding site 479435017142 MMPL family; Region: MMPL; pfam03176 479435017143 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435017144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 479435017145 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 479435017146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 479435017147 hypothetical protein; Validated; Region: PRK07682 479435017148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435017149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435017150 homodimer interface [polypeptide binding]; other site 479435017151 catalytic residue [active] 479435017152 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 479435017153 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435017154 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 479435017155 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 479435017156 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 479435017157 ParB-like partition proteins; Region: parB_part; TIGR00180 479435017158 ParB-like nuclease domain; Region: ParBc; cl02129 479435017159 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 479435017160 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435017161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 479435017162 Magnesium ion binding site [ion binding]; other site 479435017163 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 479435017164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 479435017165 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 479435017166 G-X-X-G motif; other site 479435017167 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 479435017168 RxxxH motif; other site 479435017169 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 479435017170 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 479435017171 Domain of unknown function DUF37; Region: DUF37; cl00506 479435017172 Ribonuclease P; Region: Ribonuclease_P; cl00457 479435017173 Ribosomal protein L34; Region: Ribosomal_L34; cl00370